stilbenes

Summary

Summary: Organic compounds that contain 1,2-diphenylethylene as a functional group.

Top Publications

  1. ncbi Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
  2. ncbi Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    Marie Lagouge
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 127:1109-22. 2006
  3. ncbi Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    Konrad T Howitz
    BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
    Nature 425:191-6. 2003
  4. pmc Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    Sung Jun Park
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 148:421-33. 2012
  5. pmc Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    Silvie Timmers
    Top Institute Food and Nutrition TIFN, Wageningen, The Netherlands
    Cell Metab 14:612-22. 2011
  6. pmc Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    Fan Yeung
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 23:2369-80. 2004
  7. ncbi Therapeutic potential of resveratrol: the in vivo evidence
    Joseph A Baur
    Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Rev Drug Discov 5:493-506. 2006
  8. ncbi Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Anticancer Res 24:2783-840. 2004
  9. ncbi Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    Pál Brasnyó
    2nd Department of Internal Medicine and Nephrological Center, Faculty of Medicine, University of Pecs, Pacsirta Street 1, Pecs H 7624, Hungary
    Br J Nutr 106:383-9. 2011
  10. ncbi High absorption but very low bioavailability of oral resveratrol in humans
    Thomas Walle
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Dispos 32:1377-82. 2004

Detail Information

Publications335 found, 100 shown here

  1. ncbi Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
  2. ncbi Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    Marie Lagouge
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 127:1109-22. 2006
    ..These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis...
  3. ncbi Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    Konrad T Howitz
    BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
    Nature 425:191-6. 2003
    ..We discuss possible evolutionary origins of this phenomenon and suggest new lines of research into the therapeutic use of sirtuin activators...
  4. pmc Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    Sung Jun Park
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 148:421-33. 2012
    ..Therefore, administration of PDE4 inhibitors may also protect against and ameliorate the symptoms of metabolic diseases associated with aging...
  5. pmc Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    Silvie Timmers
    Top Institute Food and Nutrition TIFN, Wageningen, The Netherlands
    Cell Metab 14:612-22. 2011
    ..In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction...
  6. pmc Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    Fan Yeung
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 23:2369-80. 2004
    ....
  7. ncbi Therapeutic potential of resveratrol: the in vivo evidence
    Joseph A Baur
    Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Rev Drug Discov 5:493-506. 2006
    ..Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans...
  8. ncbi Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Anticancer Res 24:2783-840. 2004
    ..Limited data in humans have revealed that resveratrol is pharmacologically quite safe. Currently, structural analogues of resveratrol with improved bioavailability are being pursued as potential therapeutic agents for cancer...
  9. ncbi Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    Pál Brasnyó
    2nd Department of Internal Medicine and Nephrological Center, Faculty of Medicine, University of Pecs, Pacsirta Street 1, Pecs H 7624, Hungary
    Br J Nutr 106:383-9. 2011
    ....
  10. ncbi High absorption but very low bioavailability of oral resveratrol in humans
    Thomas Walle
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Dispos 32:1377-82. 2004
    ....
  11. ncbi Chemopreventive effects of resveratrol and resveratrol derivatives
    Thomas Szekeres
    Institute for Laboratory Medicine, Department for Medical, Medical University of Vienna, General Hospital of Vienna, Austria
    Ann N Y Acad Sci 1215:89-95. 2011
    ..Hydroxylated resveratrol analogs therefore represent a novel class of anticancer compounds and promising candidates for in vivo studies...
  12. ncbi Resveratrol in human cancer chemoprevention--choosing the 'right' dose
    Edwina Scott
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Mol Nutr Food Res 56:7-13. 2012
    ..New experimental paradigms need to be used to obtain information on pharmacological changes elicited by resveratrol when present at very low concentrations or when administered at dietary-relevant doses...
  13. ncbi Mechanism of human SIRT1 activation by resveratrol
    Margie T Borra
    Department of Biomolecular Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 280:17187-95. 2005
    ..We propose that binding of resveratrol to SIRT1 promotes a conformational change that better accommodates the attached coumarin group...
  14. pmc Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis
    Victoria A Brown
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
    Cancer Res 70:9003-11. 2010
    ..The observed decrease in circulating IGF-I and IGFBP-3 might contribute to cancer chemopreventive activity...
  15. ncbi Recent advances in the study on resveratrol
    Rieko Nakata
    Department of Food Science and Nutrition, Nara Women s University, Kitauoyanishi machi, Japan
    Biol Pharm Bull 35:273-9. 2012
    ..Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health...
  16. pmc What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
    Ole Vang
    Department of Science, System and Models, Roskilde University, Roskilde, Denmark
    PLoS ONE 6:e19881. 2011
    ..Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark...
  17. pmc SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
    Dohoon Kim
    Howard Hughes Medical Institute, Picower Insitute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Boston, MA, USA
    EMBO J 26:3169-79. 2007
    ..Thus, SIRT1 constitutes a unique molecular link between aging and human neurodegenerative disorders and provides a promising avenue for therapeutic intervention...
  18. pmc Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    Kevin J Pearson
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Metab 8:157-68. 2008
    ..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife...
  19. pmc Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients
    Ketan R Patel
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
    Cancer Res 70:7392-9. 2010
    ..5 or 1.0 g produce levels in the human gastrointestinal tract of an order of magnitude sufficient to elicit anticarcinogenic effects. Resveratrol merits further clinical evaluation as a potential colorectal cancer chemopreventive agent...
  20. ncbi Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents
    Wonyoung Kang
    Department of Toxicology and Biochemistry, College of Veterinary Medicine, Jeju National University, Jeju 690 756, Republic of Korea
    Metabolism 61:424-33. 2012
    ..Our results show that RSV enhances insulin action only under insulin-resistant conditions and suggest that the effect of RSV may depend on the type of tissue being targeted and its metabolic status...
  21. pmc Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    Jill C Milne
    Sirtris Pharmaceuticals Inc, 790 Memorial Drive, Cambridge, Massachusetts 02139, USA
    Nature 450:712-6. 2007
    ..Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes...
  22. pmc Pilot study of resveratrol in older adults with impaired glucose tolerance
    JILL P CRANDALL
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    J Gerontol A Biol Sci Med Sci 67:1307-12. 2012
    ..In a pilot study, we tested the hypothesis that resveratrol improves glucose metabolism and vascular function in older adults with impaired glucose tolerance (IGT)...
  23. ncbi Substrate-specific activation of sirtuins by resveratrol
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:17038-45. 2005
    ..In light of these findings, the mechanism accounting for putative longevity effects of resveratrol should be reexamined...
  24. ncbi Resveratrol and health--a comprehensive review of human clinical trials
    James M Smoliga
    Human Physiology Laboratory, Department of Health and Physical Education, Marywood University, Scranton, PA 18509, USA
    Mol Nutr Food Res 55:1129-41. 2011
    ..This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials...
  25. ncbi Clinical trials of resveratrol
    Ketan R Patel
    Department of Cancer Studies and Molecular Medicine, University of Leicester, United Kingdom
    Ann N Y Acad Sci 1215:161-9. 2011
    ..This review describes the available clinical data, outlines how it supports the continuing development of resveratrol, and suggests what additional information is needed to increase the chances of success in future clinical trials...
  26. ncbi Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
    David J Boocock
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester University, Leicester LE2 7LX, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:1246-52. 2007
    ..However, the high systemic levels of resveratrol conjugate metabolites suggest that their cancer chemopreventive properties warrant investigation...
  27. ncbi Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice
    Soyoung Kim
    Department of Food and Nutrition, Yonsei University, Seongsanno Seodaemun gu, Seoul, South Korea
    Biochem Pharmacol 81:1343-51. 2011
    ..It may also attenuate cytokine production in the adipose tissue by repressing the TLR2- and TLR4-mediated pro-inflammatory signaling cascades in HFD-fed mice...
  28. pmc Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease
    Joao Tomé-Carneiro
    Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS CSIC, 30100 Campus de Espinardo, Murcia, Spain
    Cardiovasc Drugs Ther 27:37-48. 2013
    ....
  29. ncbi One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease
    Joao Tomé-Carneiro
    Research Group on Quality, Safety, and Bioactivity of Plant Foods, CEBAS CSIC, Murcia, Spain
    Am J Cardiol 110:356-63. 2012
    ..e., with diabetes or hypercholesterolemia plus ≥1 other CV risk factor). Our results show for the first time that a dietary intervention with grape resveratrol could complement the gold standard therapy in the primary prevention of CVD...
  30. pmc The journey of resveratrol from yeast to human
    Silvie Timmers
    Top Institute Food and Nutrition TIFN, Wageningen, The Netherlands
    Aging (Albany NY) 4:146-58. 2012
    ..Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation...
  31. ncbi Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease
    K Magyar
    1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary
    Clin Hemorheol Microcirc 50:179-87. 2012
    ....
  32. ncbi Biological activity of piceatannol: leaving the shadow of resveratrol
    Hanna Piotrowska
    Department of Toxicology, Poznan University of Medical Sciences, ul Dojazd 30, 60 631 Poznan, Poland
    Mutat Res 750:60-82. 2012
    ....
  33. pmc Chemosensitization of tumors by resveratrol
    Subash C Gupta
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Ann N Y Acad Sci 1215:150-60. 2011
    ..The potential mechanisms underlying this dual effect are discussed. Overall, studies suggest that resveratrol can be used to sensitize tumors to standard cancer chemotherapeutics...
  34. pmc Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
    Sean M Armour
    Department of Pathology and Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA
    Aging (Albany NY) 1:515-28. 2009
    ..These data indicate that S6K1 is important for the full induction of autophagy in mammals and raise the possibility that some of the beneficial effects of resveratrol are due to modulation of S6K1 activity...
  35. ncbi Resveratrol is not a direct activator of SIRT1 enzyme activity
    Dirk Beher
    Department of Neuroscience, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Chem Biol Drug Des 74:619-24. 2009
    ..In consequence, our data challenge the overall utility of resveratrol as a pharmacological tool to directly activate SIRT1...
  36. ncbi Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions
    A R Neves
    REQUIMTE, Departamento de Quimica, Universidade do Porto, Rua Anibal Cunha, Porto, Portugal
    Curr Med Chem 19:1663-81. 2012
    ....
  37. ncbi Cellular and molecular effects of resveratrol in health and disease
    Wei Yu
    Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, People s Republic of China
    J Cell Biochem 113:752-9. 2012
    ..In this review, we discuss the latest cellular and molecular findings that account for the beneficial actions of resveratrol...
  38. ncbi Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity
    Connie M Remsberg
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University Pullman, Washington 99164 6534, USA
    Phytother Res 22:169-79. 2008
    ..Pterostilbene exhibited concentration-dependent antioxidant capacity measured by the ABTS method. Pterostilbene increased the latency period to response in both tail-flick and hot-plate analgesic tests...
  39. pmc A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
    Jamie L Barger
    LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
    PLoS ONE 3:e2264. 2008
    ..Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR...
  40. ncbi Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling
    P Palsamy
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600 025 Tamilnadu, India
    Biochim Biophys Acta 1812:719-31. 2011
    ..These findings demonstrated the renoprotective nature of resveratrol by attenuating markers of oxidative stress in renal tissues of diabetic rats...
  41. pmc Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
    E Morselli
    INSERM, U848, Villejuif F 94805, France
    Cell Death Dis 1:e10. 2010
    ..We conclude that autophagy is universally required for the lifespan-prolonging effects of caloric restriction and pharmacological Sirtuin-1 activators...
  42. ncbi Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
    Mengwei Zang
    Vascular Biology Unit, Boston University Medical Center, 650 Albany St, X704, MA 02118, USA
    Diabetes 55:2180-91. 2006
    ....
  43. pmc Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Aging Cell 8:113-27. 2009
    ..Understanding the genetic network by which different DR regimens extend lifespan has important implications for harnessing the full benefits of DR on lifespan and healthspan...
  44. ncbi Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate
    Dario R Valenzano
    Scuola Normale Superiore, 56100 Pisa, Italy
    Curr Biol 16:296-300. 2006
    ..These results demonstrate that food supplementation with resveratrol prolongs lifespan and retards the expression of age-dependent traits in a short-lived vertebrate...
  45. ncbi The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: cell-specific alteration of the cell cycle
    Eulalia Pozo-Guisado
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s n, 06071, Badajoz, Spain
    Biochem Pharmacol 64:1375-86. 2002
    ..This could be influenced, among other factors, by the concentration of this molecule and by the characteristics of the target cell...
  46. ncbi At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
    Zoya N Demidenko
    Oncotarget, Albany, NY, USA
    Cell Cycle 8:1901-4. 2009
    ....
  47. ncbi Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation
    Alexandre Puissant
    INSERM 895, Team 2 Cell Death Differentiation and Cancer, Laboratoire d OncoHématologie, Centre Hospitalier Universitaire de Nice, Nice, France
    Cancer Res 70:1042-52. 2010
    ..We concluded that RSV triggered autophagic cell death in CML cells via both JNK-mediated p62 overexpression and AMPK activation. Our findings show that the JNK and AMPK pathways can cooperate to eliminate CML cells via autophagy...
  48. ncbi Resveratrol: its biologic targets and functional activity
    Shazib Pervaiz
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Antioxid Redox Signal 11:2851-97. 2009
    ..In this review, we present a comprehensive account of the basic chemistry of RSV, its bioavailability, and its multiple intracellular target proteins and signaling pathways...
  49. pmc SIRT1 negatively regulates the mammalian target of rapamycin
    Hiyaa Singhee Ghosh
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e9199. 2010
    ..These results demonstrate that SIRT1 negatively regulates mTOR signaling potentially through the TSC1/2 complex...
  50. ncbi Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    Jason G Wood
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 430:686-9. 2004
    ..Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction...
  51. pmc SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
    Michelle Pacholec
    Department of Cardiovascular, Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    J Biol Chem 285:8340-51. 2010
    ..Taken together, we conclude that SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1...
  52. ncbi Resveratrol: a multitargeted agent for age-associated chronic diseases
    Kuzhuvelil B Harikumar
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cell Cycle 7:1020-35. 2008
    ..Efforts are also underway to improve its activity in vivo through structural modification and reformulation. Our review describes various targets of resveratrol and their therapeutic potential...
  53. ncbi Pterostilbene and cancer: current review
    Denise McCormack
    Department of Surgery, Danbury Hospital, Danbury, Connecticut 06810, USA
    J Surg Res 173:e53-61. 2012
    ..In this review, we present a comprehensive summary of the antineoplastic mechanisms of pterostilbene based on the results of preclinical studies and highlight recent advances in the study of this dietary compound...
  54. pmc Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell development
    Lindsay Peltz
    Biological Sciences Department, California State Polytechnic University at Pomona, Pomona, California, United States of America
    PLoS ONE 7:e37162. 2012
    ..1 µM and caution should be taken in applying resveratrol as an anticancer therapeutic agent or nutraceutical supplement due to its dosage dependent effect on hMSCs...
  55. pmc Development of novel cationic chitosan-and anionic alginate-coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol
    Vanna Sanna
    Porto Conte Ricerche, Alghero, Italy
    Int J Nanomedicine 7:5501-16. 2012
    ....
  56. pmc Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
    Munehiro Kitada
    Division of Diabetes and Endocrinology, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
    Diabetes 60:634-43. 2011
    ..This study examined the renoprotective effects of RSV in db/db mice, a model of type 2 diabetes...
  57. pmc AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism
    Valérie Vingtdeux
    Litwin Zucker Research Center for the Study of Alzheimer s Disease, The Feinstein Institute for Medical Research, North Shore LIJ, Manhasset, New York 11030, USA
    J Biol Chem 285:9100-13. 2010
    ..These data suggest that resveratrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease...
  58. ncbi Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line
    Prasun Guha
    Department of Biochemistry, Dr B C Roy Postgraduate Institute of Basic Medical Sciences and I P G M E and R, 244B, Acharya Jagadish Chandra Bose Road, Kolkata 700 020, India
    J Pharmacol Exp Ther 336:206-14. 2011
    ....
  59. ncbi Differential effects of resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells
    Thomas T Y Wang
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA
    Mol Nutr Food Res 54:335-44. 2010
    b>Stilbenes are phytoalexins that become activated when plants are stressed. These compounds exist in foods and are widely consumed...
  60. ncbi The controversial links among calorie restriction, SIRT1, and resveratrol
    Yi Hu
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Free Radic Biol Med 51:250-6. 2011
    ..In this review, we will discuss the emerging roles of SIRT1 and resveratrol in CR and focus on debate over the links between SIRT1 and resveratrol...
  61. pmc Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts
    Xiaoxia Zhu
    Division of Rheumatology, Shanghai Medical College, Fudan University, Huashan Hospital, Shanghai, China
    PLoS ONE 6:e27081. 2011
    ..It suggests that Sirt1 is an efficient target for regulation of inflammation. This study provides insight on treatment of inflammation-related diseases...
  62. pmc Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
    Heehyoung Lee
    Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 109:7765-9. 2012
    ..These findings also provide a rationale for targeting acetylated STAT3 for chemoprevention and cancer therapy...
  63. pmc Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus
    Julia Marchal
    Mecanismes Adaptatifs et Evolution, UMR 7179 Centre National de la Recherche Scientifique, Museum national d histoire naturelle, Brunoy, France
    PLoS ONE 7:e34289. 2012
    ..These results suggest that both CR and RSV have beneficial effects on metabolic alterations, although these effects are different in amplitude between the two anti-aging treatments and potentially rely on different metabolic changes...
  64. pmc Resveratrol: a review of preclinical studies for human cancer prevention
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street VC15 204, New York, NY 10032, USA
    Toxicol Appl Pharmacol 224:274-83. 2007
    ..This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations...
  65. ncbi Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications
    C Alarcon de la Lastra
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
    Biochem Soc Trans 35:1156-60. 2007
    ..The present paper is intended to provide the reader up-to-date information on the antioxidant and pro-oxidant properties of resveratrol and its clinical implications...
  66. pmc Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
    Saravanan S Karuppagounder
    Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, United States
    Neurochem Int 54:111-8. 2009
    ..This study supports the concept that onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemo-preventive agents that protect against beta-amyloid plaque formation and oxidative stress...
  67. pmc Resveratrol differentially modulates inflammatory responses of microglia and astrocytes
    Xiaofeng Lu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Neuroinflammation 7:46. 2010
    ..We investigated the capacity of resveratrol to protect microglia and astrocyte from inflammatory insults and explored mechanisms underlying different inhibitory effects of resveratrol on microglia and astrocytes...
  68. pmc AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    Jee Hyun Um
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 59:554-63. 2010
    ..Here, we use mice deficient in AMPKalpha1 or -alpha2 to determine whether the metabolic effects of resveratrol are mediated by AMPK...
  69. pmc Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition
    Sharmila Shankar
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e16530. 2011
    ..The objectives of this study were to examine the molecular mechanisms by which resveratrol inhibits stem cell characteristics of pancreatic CSCs derived from human primary tumors and Kras(G12D) transgenic mice...
  70. pmc Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats
    Anna Csiszar
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Hypertension 54:668-75. 2009
    ..Our studies show that resveratrol exerts anti-inflammatory, antioxidant, and antiproliferative effects in the pulmonary arteries, which may contribute to the prevention of pulmonary hypertension...
  71. pmc Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms
    Mohammad Athar
    Departments of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, NY 10032, USA
    Arch Biochem Biophys 486:95-102. 2009
    ..This review summarizes in vitro mechanistic data available for resveratrol and discusses new potential anti-cancer targets and the antiproliferative mechanisms of resveratrol...
  72. ncbi SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
    Jennifer Chen
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
    J Biol Chem 280:40364-74. 2005
    ..They also implicate SIRT1 in this pathway and highlight the therapeutic potential of resveratrol and other sirtuin-activating compounds in Alzheimer disease...
  73. ncbi Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications
    Catalina Alarcón de la Lastra
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
    Mol Nutr Food Res 49:405-30. 2005
    ..Also, this review is intended to provide the reader an up-date of the bioavailability and pharmacokinetics of resveratrol and its impact on lifespan...
  74. pmc Resveratrol induces mitochondrial biogenesis in endothelial cells
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 297:H13-20. 2009
    ..Resveratrol induced mitochondrial biogenesis in the aortas of type 2 diabetic mice, suggesting the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases...
  75. pmc Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase
    Mahesh Thirunavukkarasu
    Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut Medical Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
    Free Radic Biol Med 43:720-9. 2007
    ..Thus this study shows a novel mechanism of pharmacological preconditioning with resveratrol in the diabetic myocardium...
  76. ncbi Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?
    Philipp Saiko
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Mutat Res 658:68-94. 2008
    ..Nonetheless, the question of whether RV or its metabolites can accumulate to bioactive levels in target organs remains to be addressed...
  77. ncbi Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
    Elizabeth D Brookins Danz
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 46:1589-97. 2009
    ..Our data suggest that RV protects against DOX-induced oxidative stress through changes in mitochondrial function, specifically the Sirt1 pathway leading to cardiac cell survival...
  78. pmc Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
    Jesse J Smith
    Sirtris, a GSK Company, 200 Technology Square, Cambridge, MA 02139, USA
    BMC Syst Biol 3:31. 2009
    ....
  79. pmc Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    Frederic Picard
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 429:771-6. 2004
    ..As a reduction in fat is sufficient to extend murine lifespan, our results provide a possible molecular pathway connecting calorie restriction to life extension in mammals...
  80. pmc Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway
    Ji Hyun Lee
    Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, Korea
    Diabetes 58:344-51. 2009
    ..Because of the central role of NF-kappaB in cytokine-mediated pancreatic beta-cell damage, we postulated that SIRT1 might work in pancreatic beta-cell damage models...
  81. ncbi Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats
    Leonor Rivera
    Department of Pharmacology, CIBER EHD, CTS 164 Research Group, School of Pharmacy, University of Granada, Campus Universitario Cartuja s n, 18071 Granada, Spain
    Biochem Pharmacol 77:1053-63. 2009
    ..In conclusion, resveratrol improved dyslipidemia, hyperinsulinemia, hyperleptinemia and hypertension in obese Zucker rats, and produced anti-inflammatory effects in VAT, effects that seem to be mediated by AMPK activation...
  82. ncbi Resveratrol protects against global cerebral ischemic injury in gerbils
    Qun Wang
    Department of Pharmacology, School of Medicine, M526 Medical Science Bldg, 1 Hospital Drive, University of Missouri Columbia, Columbia, MO 65212, USA
    Brain Res 958:439-47. 2002
    ..This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury...
  83. ncbi Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
    J Alex Parker
    Institut National de la Sante et de la Recherche Medicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, 75014 Paris, France
    Nat Genet 37:349-50. 2005
    ..Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines...
  84. ncbi Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models
    K P Bhat
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 61:7456-63. 2001
    ..In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited. These data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer...
  85. ncbi Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells
    Chu Yue Chen
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 331:993-1000. 2005
    ..Taken together, the above findings suggest that resveratrol augments cellular antioxidant defense capacity through induction of HO-1 via Nrf2-ARE signaling, thereby protecting PC12 cells from oxidative stress...
  86. ncbi Colorectal cancer chemoprevention by trans-resveratrol
    M Emília Juan
    Departament de Fisiologia, Universitat de Barcelona, Av Joan XXIII s n, E 08028 Barcelona, Spain
    Pharmacol Res 65:584-91. 2012
    ..Lastly, the article also reviews the available data on clinical trials. Altogether, the present findings support the hypothesis that the oral administration of trans-resveratrol might contribute to the prevention of colon carcinogenesis...
  87. ncbi Cancer chemoprevention through dietary antioxidants: progress and promise
    Naghma Khan
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Antioxid Redox Signal 10:475-510. 2008
    ..This research is also leading to the identification of novel cancer drug targets...
  88. ncbi The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol
    K Teskac
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, Ljubljana, Slovenia
    Int J Pharm 390:61-9. 2010
    ..The cytostatic effect of SLN-RSV was much more expressed than that of RSV in solution. Delivery of RSV by SLN contributes to effectiveness of RSV on decreasing cell proliferation, with potential benefits for prevention of skin cancer...
  89. ncbi Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection
    Merce Pallas
    Facultat de Farmacia, Institut de Biomedicina IBUB, Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Curr Neurovasc Res 6:70-81. 2009
    ..In addition, we discuss the possibility of using resveratrol in the treatment of neurodegenerative diseases...
  90. ncbi Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells
    F Scarlatti
    Laboratory of Biochemistry and Mol Biology, San Paolo University Hospital, Medical School, University of Milan, Milan, Italy
    Cell Death Differ 15:1318-29. 2008
    ..In conclusion, this study reveals that non-canonical autophagy induced by resveratrol can act as a caspase-independent cell death mechanism in breast cancer cells...
  91. ncbi Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters
    Agnes M Rimando
    Natural Products Utilization Research Unit, ARS, U S Department of Agriculture, Mississippi 38677, USA
    J Agric Food Chem 53:3403-7. 2005
    ..The four stilbenes were evaluated at 1, 10, 100, and 300 microM along with ciprofibrate (positive control), for the activation of ..
  92. ncbi A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
    Mohan Viswanathan
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Dev Cell 9:605-15. 2005
    ..1-mediated repression of ER stress genes. Our findings demonstrate that abu-11 and other members of its ER stress gene family are positive determinants of C. elegans life span...
  93. pmc Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinus
    Alexandre Dal-Pan
    Mecanismes Adaptatifs et Evolution, UMR 7179 Centre National de la Recherche Scientifique, Museum national d histoire naturelle, 1 avenue du petit château, Brunoy, France
    Age (Dordr) 33:15-31. 2011
    ..The RESTRIKAL study can now be safely undertaken on a long-term basis to determine whether age-associated alterations in mouse lemurs are delayed with CR and if RSV can mimic these effects...
  94. pmc Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway
    D Della-Morte
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Neuroscience 159:993-1002. 2009
    ..In conclusion, in vivo resveratrol pretreatment confers neuroprotection similar to IPC via the SIRT1-UCP2 pathway...
  95. ncbi Administration of resveratrol: What formulation solutions to bioavailability limitations?
    A Amri
    Laboratoire de Pharmacie Galenique, EA4466, Universite Paris Descartes, Sorbonne Paris Cité, Faculte des Sciences Pharmaceutiques et Biologiques, Paris, France
    J Control Release 158:182-93. 2012
    ....
  96. pmc Resveratrol stimulates AMP kinase activity in neurons
    Biplab Dasgupta
    Departments of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:7217-22. 2007
    ..These findings suggest that neuronal activation of AMPK by resveratrol could affect neuronal energy homeostasis and contribute to the neuroprotective effects of resveratrol...
  97. pmc Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR
    Meilian Liu
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 285:36387-94. 2010
    ..Taken together, our studies reveal that RSV inhibits leucine-stimulated mTORC1 activation by promoting mTOR/DEPTOR interaction and thus uncover a novel mechanism by which RSV negatively regulates mTOR activity...
  98. ncbi Resveratrol and cellular mechanisms of cancer prevention
    Yogeshwer Shukla
    Indian Institute of Toxicology Research, Lucknow, India
    Ann N Y Acad Sci 1215:1-8. 2011
    ..Here, we focus on some of the myriad pathways that resveratrol targets to exert its chemopreventive role and advocate that resveratrol holds tremendous potential as an efficient anticancer drug of the future...
  99. ncbi Resveratrol-induced autophagocytosis in ovarian cancer cells
    Anthony W Opipari
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 64:696-703. 2004
    ....
  100. ncbi Resveratrol, pterostilbene, and piceatannol in vaccinium berries
    Agnes M Rimando
    Natural Products Utilization Research Unit, ARS, U S Department of Agriculture, P O Box 8048, University, Mississippi 38677, Agriculture and Agri Food Canada, Kentville, Nova Scotia B4N 1J5, Canada
    J Agric Food Chem 52:4713-9. 2004
    ..corymbosum and V. stamineum at levels of 138-422 ng/g dry sample. These naturally occurring stilbenes, known to be strong antioxidants and to have cancer chemopreventive activities, will add to the purported health ..
  101. ncbi Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells
    Po Lin Kuo
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan
    Life Sci 72:23-34. 2002
    ....

Research Grants69

  1. SPECT Imaging of Abeta Plaques in Brain
    Mei Ping Kung; Fiscal Year: 2006
    ..The proposed agents are derivatives of stilbenes containing a p-MezN-, -SH, -SMe, -0Me or -OH group on one of the benzene rings, while radioactive iodine can be ..
  2. Mechanisms of Reduced Heart Failure Pathogenesis with Phytochemical Intake
    Steven F Bolling; Fiscal Year: 2012
    ..Grape phytochemicals of broad interest include anthocyanins, flavanols (catechin, epicatechin, quercetin), and stilbenes (resveratrol)...
  3. Pawhuskins: Potential Treatments for Stimulant Abuse.
    Jeffrey D Neighbors; Fiscal Year: 2010
    ..The pawhuskins are a small set of prenylated stilbenes reported from a North American prairie plant in 2004...
  4. CELL AND MOLECULAR BIOLOGY OF SECRETARY CL CHANNELS
    Dale Benos; Fiscal Year: 1993
    ..Cl- channel; 3) immunocytochemical localization and intracellular trafficking of Cl- channels; and 4) disulfonic stilbenes as probes of reconstituted Cl- channels...
  5. New Phase Tags and Sorting Tags for Organic Synthesis
    CRAIG WILCOX; Fiscal Year: 2005
    ..This project will study two types of protean phase tags: (1) recyclable precipitons based on stilbenes for controlling organic solubility, and (2) new protean phase tags for controlling water solubility...
  6. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  7. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  8. Chemoprevention of prostate cancer by resveratrol
    Tze Chen Hsieh; Fiscal Year: 2005
    ....
  9. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2008
    ..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. [unreadable] [unreadable]..
  10. PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURY
    DIPAK DAS; Fiscal Year: 2009
    ....
  11. MYOCARDIAL PRESERVATION DURING ISCHEMIC ARREST
    DIPAK DAS; Fiscal Year: 2009
    ..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
  12. Nutritional Supplements and Cancer Chemoprevention
    JOHN PEZZUTO; Fiscal Year: 2002
    ..Attracting the attention of these participants should provide a valuable pedagogical experience and help to foster additional progress in the field of cancer chemoprevention. ..
  13. Regulation of breast cancer growth by activation peptide
    Vaclav Vetvicka; Fiscal Year: 2006
    ..The overall goal is to generate a pharmacological agent for breast cancer based on blockage of the autocrine growth factor activity of pCD. ..
  14. Hemodynamic forces regulate BMPs in coronary arteries
    Zoltan Ungvari; Fiscal Year: 2009
    ..abstract_text> ..
  15. Does SIRT1 regulate mammalian health and longevity?
    JOSEPH BAUR; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  16. Synthesis of the myrmicarin family of natural products
    Scott Snyder; Fiscal Year: 2005
    ....
  17. Cell Cycle and COX-2 in a Mouse Model of Alzheimer's
    Giulio Pasinetti; Fiscal Year: 2004
    ....
  18. RADIATION AND DRUG EFFECTS ON TUMOR CELL SUBPOPULATIONS
    Dietmar Siemann; Fiscal Year: 2001
    ..Ultimately we hope that these approaches can be reliably developed to an extent where the use of human tumor biopsy material may lead to radiotherapy treatments more tailored to the individual patient. ..
  19. CYCLOOXYGENASE AND ANTI-INFLAMMATORY DRUGS IN AD
    Giulio Pasinetti; Fiscal Year: 2001
    ..The outcome of the proposed studies will be immediately relevant to the design of human trials. ..
  20. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  21. Pinitol a Natural Extract from Pine Cones and Alzheimer's Disease
    Giulio Pasinetti; Fiscal Year: 2006
    ..abstract_text> ..
  22. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  23. Novel target proteins of resveratrol in chemoprevention
    Joseph Wu; Fiscal Year: 2005
    ..abstract_text> ..
  24. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  25. COMPLEMENT AND NEUROPROTECTION: ALZHEIMER'S DISEASE
    Giulio Pasinetti; Fiscal Year: 2002
    ..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
  26. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  27. Functional synergism in prevention of hormone refractory CaP by phytochemicals
    Joseph Wu; Fiscal Year: 2007
    ..The data obtained will support the concept that combined diet-derived phytochemicals can offer easily compliant strategies for protection against HRPC. [unreadable] [unreadable] [unreadable]..
  28. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  29. Prevention of Neuronal Damage in Optic Neuritis
    KENNETH SHINDLER; Fiscal Year: 2008
    ..This proposal will serve as an ideal platform for the principal investigator to begin a career aimed at understanding mechanisms of optic nerve damage and its correlation to clinical findings. [unreadable] [unreadable]..
  30. Human Monoclonal Antibodies against Botulinum Toxins
    Kim Janda; Fiscal Year: 2007
    ..The proposed research provides a foundation for the use of human IgGs against BoNTs by military personnel during warfare or the general public in the event of bioterrorist activity. ..
  31. International Trace Elements Conference
    Janet King; Fiscal Year: 2002
    ..The purpose of this proposal is to seek funding for the travel of selected speakers, young investigator awards, and publication of the proceedings. ..
  32. Mechanism Based Chemoprevention of Cancer
    Nanjoo Suh; Fiscal Year: 2005
    ..My long-term goal is to become an independent investigator who can contribute to the entire process of making basic scientific knowledge effective in preventing cancer in men and women. ..
  33. NAD+ control of transcriptional silencing and longevity
    David Sinclair; Fiscal Year: 2007
    ..As far as we are aware, our approach to understanding this fundamental regulatory network is unique. [unreadable] [unreadable]..
  34. Ferroportin and iron export from the macrophage
    Mitchell Knutson; Fiscal Year: 2007
    ..abstract_text> ..
  35. Evaluation of resveratrol and curcumin as therapeutics against high-risk leukemia
    SUSAN ZUNINO; Fiscal Year: 2008
    ..These studies will provide information about whether the plant antioxidants resveratrol and curcumin may be novel and efficient alternatives for the treatment of high-risk leukemia. [unreadable] [unreadable] [unreadable]..
  36. 2009 Biology of Aging Gordon Research Conference
    David Sinclair; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. ROLE OF CHROMATIN IN HIV TRANSCRIPTIONAL REGULATION
    ERIC M VERDIN; Fiscal Year: 2010
    ..These experiments have the potential of identifying novel factors mediating HIV transcriptional regulation that could be targeted therapeutically in the future. ..
  38. PG receptors in controling excitotoxicity in aging brain
    SYLVAIN DORE; Fiscal Year: 2008
    ..abstract_text> ..
  39. Chk2 as a target for regulating senescence in skin neoplasia
    Arianna Kim; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. Multifunctional Antioxidants as Anti-Cataract Agents
    Peter Kador; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  41. Yeast screens for genetic & chemical mimetics of CR
    David Sinclair; Fiscal Year: 2006
    ..The longer-term goal is to test the genes and compounds we identify for their ability to extend life span in C. elegans. The knowledge gained should serve to guide searches for compounds that retard aging in mammals. ..
  42. A Protein-Polymer Approach to Neural Tissue Regeneration
    Kim Janda; Fiscal Year: 2005
    ..We envisage that the initial studies described herein will serve as the foundation for further studies in our laboratory in the design and chemical synthesis of biomimetic tissue regeneration matrices. ..
  43. Resveratrol, Mechanism of Neuroprotection
    SYLVAIN DORE; Fiscal Year: 2005
    ..abstract_text> ..
  44. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
    ....
  45. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
    ..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
  46. GENETICS OF AGE SENSITIVE TRAITS IN MICE
    Richard Miller; Fiscal Year: 2003
    ..At best, the program may permit the localization of loci that influence multiple age-sensitive domains and are thus plausible candidates for genes that regulate the rate of aging per se. ..
  47. CATALYTIC ANTIBODIES
    Kim Janda; Fiscal Year: 2002
    ..Access to new tailor-made antibody catalysts would advance the field and shed light on enzyme mechanisms and evolution, and provide potentially valuable immunological reagents for use in medicine and industry. ..
  48. MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA
    STEPHEN ALWAY; Fiscal Year: 2001
    ....
  49. Integrated Instrumentation for Proteomics
    Helen Kim; Fiscal Year: 2002
    ....
  50. IRON SUPPLEMENTS AND ZINC IN PREGNANCY AND LACTATION
    Janet King; Fiscal Year: 2001
    ..Results from this comprehensive, longitudinal study will provide new data on the effects of iron supplementation on zinc utilization during pregnancy and lactation. ..
  51. FLAVONOID BIOAVAILABILITY IN HUMANS-CELLULAR STUDIES
    Thomas Walle; Fiscal Year: 2005
    ..The findings from the proposed studies should help us understand the bioavailability of the flavonoids, facilitating optimization of the chemopreventive utility of these natural or synthetic compounds. ..
  52. Neuroprotective mechanisms of EGb-761
    SYLVAIN DORE; Fiscal Year: 2005
    ..It could provide new pathways to support the theory that EGb could provide brain's resistance in conditions of ischemia and aged-related dementia. ..
  53. Chemoprevention of cancer by nuclear receptor ligands
    Nanjoo Suh; Fiscal Year: 2005
    ..The goal of this proposal is to develop novel ligands for the vitamin D receptor as potential chemopreventive agents that can ultimately be used to prevent breast cancer. ..
  54. High-Throughput Identification of BoNT Inhibitors
    Kim Janda; Fiscal Year: 2005
    ..Furthermore, these studies may provide new pharmacophores which can be rapidly translated into novel drugs capable of treating BoNT exposure. ..
  55. Synthesis through N-Acylnitrenium Ion Cyclization
    DUNCAN WARDROP; Fiscal Year: 2006
    ..abstract_text> ..
  56. Catalytic Antibodies as Therapy for Drug Addiction
    Kim Janda; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  57. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2006
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
  58. Cell-Penetrating Peptide Agents for Cancer Therapy
    Kim Janda; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  59. Human Monoclonal IgG for Protection against Anthrax
    Kim Janda; Fiscal Year: 2006
    ..We believe all experiments, both established and novel, will provide valuable information about the future potential of passive immunization as a treatment and/or prophylaxis for anthrax. [unreadable] [unreadable]..
  60. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  61. MOLECULAR ORIGIN OF CANCER--CATECHOL/SEMIQUINOE/QUINONE
    Ercole Cavalieri; Fiscal Year: 2003
    ..In addition, we will identify biomarkers for use in diagnosis and in studies of prevention of breast cancer and other diseases. ..
  62. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2008
    ..abstract_text> ..
  63. SPECIES SUSCEPTIBILITY TO DIABETIC COMPLICATIONS
    KENNETH GABBAY; Fiscal Year: 2002
    ....
  64. ALDO/KETO REDUCTASES AND DIABETIC COMPLICATIONS
    KENNETH GABBAY; Fiscal Year: 2001
    ....
  65. PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 2002
    ..s. ..
  66. Targeting Akt/NF-kappa beta for Pancreatic Cancer Therapy
    Fazlul Sarkar; Fiscal Year: 2007
    ..These results will provide mechanistic as well as pre-clinical data in support of our hypotheses and may open new and novel avenues for the treatment of human pancreatic cancer. ..
  67. Molecular Orgin Cancer--Catechol Estrogen 3 4 Quinones
    Ercole Cavalieri; Fiscal Year: 2004
    ..The knowledge acquired from these studies will be essential for developing preventive strategies. ..
  68. Thrombin-Stimulated Intrauterine Signaling Pathway
    Mark Phillippe; Fiscal Year: 2007
    ..These studies are anticipated to significantly improve our understanding of the mechanisms underlying preterm labor in the presence of intrauterine infection. ..