Genomes and Genes
Summary: Organic compounds that contain 1,2-diphenylethylene as a functional group.
Publications335 found, 100 shown here
- Resveratrol improves health and survival of mice on a high-calorie dietJoseph A Baur
Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 444:337-42. 2006..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
- Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alphaMarie Lagouge
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
Cell 127:1109-22. 2006..These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis...
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanKonrad T Howitz
BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
Nature 425:191-6. 2003..We discuss possible evolutionary origins of this phenomenon and suggest new lines of research into the therapeutic use of sirtuin activators...
- Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesSung Jun Park
Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell 148:421-33. 2012..Therefore, administration of PDE4 inhibitors may also protect against and ameliorate the symptoms of metabolic diseases associated with aging...
- Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humansSilvie Timmers
Top Institute Food and Nutrition TIFN, Wageningen, The Netherlands
Cell Metab 14:612-22. 2011..In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction...
- Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylaseFan Yeung
Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
EMBO J 23:2369-80. 2004....
- Therapeutic potential of resveratrol: the in vivo evidenceJoseph A Baur
Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Rev Drug Discov 5:493-506. 2006..Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans...
- Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studiesBharat B Aggarwal
Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Anticancer Res 24:2783-840. 2004..Limited data in humans have revealed that resveratrol is pharmacologically quite safe. Currently, structural analogues of resveratrol with improved bioavailability are being pursued as potential therapeutic agents for cancer...
- Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patientsPál Brasnyó
2nd Department of Internal Medicine and Nephrological Center, Faculty of Medicine, University of Pecs, Pacsirta Street 1, Pecs H 7624, Hungary
Br J Nutr 106:383-9. 2011....
- High absorption but very low bioavailability of oral resveratrol in humansThomas Walle
Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA
Drug Metab Dispos 32:1377-82. 2004....
- Chemopreventive effects of resveratrol and resveratrol derivativesThomas Szekeres
Institute for Laboratory Medicine, Department for Medical, Medical University of Vienna, General Hospital of Vienna, Austria
Ann N Y Acad Sci 1215:89-95. 2011..Hydroxylated resveratrol analogs therefore represent a novel class of anticancer compounds and promising candidates for in vivo studies...
- Resveratrol in human cancer chemoprevention--choosing the 'right' doseEdwina Scott
Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
Mol Nutr Food Res 56:7-13. 2012..New experimental paradigms need to be used to obtain information on pharmacological changes elicited by resveratrol when present at very low concentrations or when administered at dietary-relevant doses...
- Mechanism of human SIRT1 activation by resveratrolMargie T Borra
Department of Biomolecular Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Biol Chem 280:17187-95. 2005..We propose that binding of resveratrol to SIRT1 promotes a conformational change that better accommodates the attached coumarin group...
- Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axisVictoria A Brown
Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
Cancer Res 70:9003-11. 2010..The observed decrease in circulating IGF-I and IGFBP-3 might contribute to cancer chemopreventive activity...
- Recent advances in the study on resveratrolRieko Nakata
Department of Food Science and Nutrition, Nara Women s University, Kitauoyanishi machi, Japan
Biol Pharm Bull 35:273-9. 2012..Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health...
- What is new for an old molecule? Systematic review and recommendations on the use of resveratrolOle Vang
Department of Science, System and Models, Roskilde University, Roskilde, Denmark
PLoS ONE 6:e19881. 2011..Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark...
- SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosisDohoon Kim
Howard Hughes Medical Institute, Picower Insitute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Boston, MA, USA
EMBO J 26:3169-79. 2007..Thus, SIRT1 constitutes a unique molecular link between aging and human neurodegenerative disorders and provides a promising avenue for therapeutic intervention...
- Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanKevin J Pearson
Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Cell Metab 8:157-68. 2008..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife...
- Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patientsKetan R Patel
Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
Cancer Res 70:7392-9. 2010..5 or 1.0 g produce levels in the human gastrointestinal tract of an order of magnitude sufficient to elicit anticarcinogenic effects. Resveratrol merits further clinical evaluation as a potential colorectal cancer chemopreventive agent...
- Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodentsWonyoung Kang
Department of Toxicology and Biochemistry, College of Veterinary Medicine, Jeju National University, Jeju 690 756, Republic of Korea
Metabolism 61:424-33. 2012..Our results show that RSV enhances insulin action only under insulin-resistant conditions and suggest that the effect of RSV may depend on the type of tissue being targeted and its metabolic status...
- Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetesJill C Milne
Sirtris Pharmaceuticals Inc, 790 Memorial Drive, Cambridge, Massachusetts 02139, USA
Nature 450:712-6. 2007..Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes...
- Pilot study of resveratrol in older adults with impaired glucose toleranceJILL P CRANDALL
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
J Gerontol A Biol Sci Med Sci 67:1307-12. 2012..In a pilot study, we tested the hypothesis that resveratrol improves glucose metabolism and vascular function in older adults with impaired glucose tolerance (IGT)...
- Substrate-specific activation of sirtuins by resveratrolMatt Kaeberlein
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 280:17038-45. 2005..In light of these findings, the mechanism accounting for putative longevity effects of resveratrol should be reexamined...
- Resveratrol and health--a comprehensive review of human clinical trialsJames M Smoliga
Human Physiology Laboratory, Department of Health and Physical Education, Marywood University, Scranton, PA 18509, USA
Mol Nutr Food Res 55:1129-41. 2011..This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials...
- Clinical trials of resveratrolKetan R Patel
Department of Cancer Studies and Molecular Medicine, University of Leicester, United Kingdom
Ann N Y Acad Sci 1215:161-9. 2011..This review describes the available clinical data, outlines how it supports the continuing development of resveratrol, and suggests what additional information is needed to increase the chances of success in future clinical trials...
- Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agentDavid J Boocock
Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester University, Leicester LE2 7LX, United Kingdom
Cancer Epidemiol Biomarkers Prev 16:1246-52. 2007..However, the high systemic levels of resveratrol conjugate metabolites suggest that their cancer chemopreventive properties warrant investigation...
- Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in miceSoyoung Kim
Department of Food and Nutrition, Yonsei University, Seongsanno Seodaemun gu, Seoul, South Korea
Biochem Pharmacol 81:1343-51. 2011..It may also attenuate cytokine production in the adipose tissue by repressing the TLR2- and TLR4-mediated pro-inflammatory signaling cascades in HFD-fed mice...
- Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery diseaseJoao Tomé-Carneiro
Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS CSIC, 30100 Campus de Espinardo, Murcia, Spain
Cardiovasc Drugs Ther 27:37-48. 2013....
- One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular diseaseJoao Tomé-Carneiro
Research Group on Quality, Safety, and Bioactivity of Plant Foods, CEBAS CSIC, Murcia, Spain
Am J Cardiol 110:356-63. 2012..e., with diabetes or hypercholesterolemia plus ≥1 other CV risk factor). Our results show for the first time that a dietary intervention with grape resveratrol could complement the gold standard therapy in the primary prevention of CVD...
- The journey of resveratrol from yeast to humanSilvie Timmers
Top Institute Food and Nutrition TIFN, Wageningen, The Netherlands
Aging (Albany NY) 4:146-58. 2012..Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation...
- Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery diseaseK Magyar
1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary
Clin Hemorheol Microcirc 50:179-87. 2012....
- Biological activity of piceatannol: leaving the shadow of resveratrolHanna Piotrowska
Department of Toxicology, Poznan University of Medical Sciences, ul Dojazd 30, 60 631 Poznan, Poland
Mutat Res 750:60-82. 2012....
- Chemosensitization of tumors by resveratrolSubash C Gupta
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Ann N Y Acad Sci 1215:150-60. 2011..The potential mechanisms underlying this dual effect are discussed. Overall, studies suggest that resveratrol can be used to sensitize tumors to standard cancer chemotherapeutics...
- Inhibition of mammalian S6 kinase by resveratrol suppresses autophagySean M Armour
Department of Pathology and Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA
Aging (Albany NY) 1:515-28. 2009..These data indicate that S6K1 is important for the full induction of autophagy in mammals and raise the possibility that some of the beneficial effects of resveratrol are due to modulation of S6K1 activity...
- Resveratrol is not a direct activator of SIRT1 enzyme activityDirk Beher
Department of Neuroscience, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
Chem Biol Drug Des 74:619-24. 2009..In consequence, our data challenge the overall utility of resveratrol as a pharmacological tool to directly activate SIRT1...
- Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactionsA R Neves
REQUIMTE, Departamento de Quimica, Universidade do Porto, Rua Anibal Cunha, Porto, Portugal
Curr Med Chem 19:1663-81. 2012....
- Cellular and molecular effects of resveratrol in health and diseaseWei Yu
Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, People s Republic of China
J Cell Biochem 113:752-9. 2012..In this review, we discuss the latest cellular and molecular findings that account for the beneficial actions of resveratrol...
- Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activityConnie M Remsberg
Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University Pullman, Washington 99164 6534, USA
Phytother Res 22:169-79. 2008..Pterostilbene exhibited concentration-dependent antioxidant capacity measured by the ABTS method. Pterostilbene increased the latency period to response in both tail-flick and hot-plate analgesic tests...
- A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in miceJamie L Barger
LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
PLoS ONE 3:e2264. 2008..Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR...
- Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signalingP Palsamy
Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600 025 Tamilnadu, India
Biochim Biophys Acta 1812:719-31. 2011..These findings demonstrated the renoprotective nature of resveratrol by attenuating markers of oxidative stress in renal tissues of diabetic rats...
- Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagyE Morselli
INSERM, U848, Villejuif F 94805, France
Cell Death Dis 1:e10. 2010..We conclude that autophagy is universally required for the lifespan-prolonging effects of caloric restriction and pharmacological Sirtuin-1 activators...
- Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient miceMengwei Zang
Vascular Biology Unit, Boston University Medical Center, 650 Albany St, X704, MA 02118, USA
Diabetes 55:2180-91. 2006....
- Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegansEric L Greer
Department of Genetics, Stanford University, Stanford, CA 94305, USA
Aging Cell 8:113-27. 2009..Understanding the genetic network by which different DR regimens extend lifespan has important implications for harnessing the full benefits of DR on lifespan and healthspan...
- Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrateDario R Valenzano
Scuola Normale Superiore, 56100 Pisa, Italy
Curr Biol 16:296-300. 2006..These results demonstrate that food supplementation with resveratrol prolongs lifespan and retards the expression of age-dependent traits in a short-lived vertebrate...
- The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: cell-specific alteration of the cell cycleEulalia Pozo-Guisado
Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s n, 06071, Badajoz, Spain
Biochem Pharmacol 64:1375-86. 2002..This could be influenced, among other factors, by the concentration of this molecule and by the characteristics of the target cell...
- At concentrations that inhibit mTOR, resveratrol suppresses cellular senescenceZoya N Demidenko
Oncotarget, Albany, NY, USA
Cell Cycle 8:1901-4. 2009....
- Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activationAlexandre Puissant
INSERM 895, Team 2 Cell Death Differentiation and Cancer, Laboratoire d OncoHématologie, Centre Hospitalier Universitaire de Nice, Nice, France
Cancer Res 70:1042-52. 2010..We concluded that RSV triggered autophagic cell death in CML cells via both JNK-mediated p62 overexpression and AMPK activation. Our findings show that the JNK and AMPK pathways can cooperate to eliminate CML cells via autophagy...
- Resveratrol: its biologic targets and functional activityShazib Pervaiz
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Antioxid Redox Signal 11:2851-97. 2009..In this review, we present a comprehensive account of the basic chemistry of RSV, its bioavailability, and its multiple intracellular target proteins and signaling pathways...
- SIRT1 negatively regulates the mammalian target of rapamycinHiyaa Singhee Ghosh
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 5:e9199. 2010..These results demonstrate that SIRT1 negatively regulates mTOR signaling potentially through the TSC1/2 complex...
- Sirtuin activators mimic caloric restriction and delay ageing in metazoansJason G Wood
Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 430:686-9. 2004..Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction...
- SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1Michelle Pacholec
Department of Cardiovascular, Pfizer Global Research and Development, Groton, Connecticut 06340, USA
J Biol Chem 285:8340-51. 2010..Taken together, we conclude that SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1...
- Resveratrol: a multitargeted agent for age-associated chronic diseasesKuzhuvelil B Harikumar
Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Cell Cycle 7:1020-35. 2008..Efforts are also underway to improve its activity in vivo through structural modification and reformulation. Our review describes various targets of resveratrol and their therapeutic potential...
- Pterostilbene and cancer: current reviewDenise McCormack
Department of Surgery, Danbury Hospital, Danbury, Connecticut 06810, USA
J Surg Res 173:e53-61. 2012..In this review, we present a comprehensive summary of the antineoplastic mechanisms of pterostilbene based on the results of preclinical studies and highlight recent advances in the study of this dietary compound...
- Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell developmentLindsay Peltz
Biological Sciences Department, California State Polytechnic University at Pomona, Pomona, California, United States of America
PLoS ONE 7:e37162. 2012..1 µM and caution should be taken in applying resveratrol as an anticancer therapeutic agent or nutraceutical supplement due to its dosage dependent effect on hMSCs...
- Development of novel cationic chitosan-and anionic alginate-coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrolVanna Sanna
Porto Conte Ricerche, Alghero, Italy
Int J Nanomedicine 7:5501-16. 2012....
- Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathwayMunehiro Kitada
Division of Diabetes and Endocrinology, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
Diabetes 60:634-43. 2011..This study examined the renoprotective effects of RSV in db/db mice, a model of type 2 diabetes...
- AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolismValérie Vingtdeux
Litwin Zucker Research Center for the Study of Alzheimer s Disease, The Feinstein Institute for Medical Research, North Shore LIJ, Manhasset, New York 11030, USA
J Biol Chem 285:9100-13. 2010..These data suggest that resveratrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease...
- Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell linePrasun Guha
Department of Biochemistry, Dr B C Roy Postgraduate Institute of Basic Medical Sciences and I P G M E and R, 244B, Acharya Jagadish Chandra Bose Road, Kolkata 700 020, India
J Pharmacol Exp Ther 336:206-14. 2011....
- Differential effects of resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cellsThomas T Y Wang
Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA
Mol Nutr Food Res 54:335-44. 2010b>Stilbenes are phytoalexins that become activated when plants are stressed. These compounds exist in foods and are widely consumed...
- The controversial links among calorie restriction, SIRT1, and resveratrolYi Hu
Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
Free Radic Biol Med 51:250-6. 2011..In this review, we will discuss the emerging roles of SIRT1 and resveratrol in CR and focus on debate over the links between SIRT1 and resveratrol...
- Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblastsXiaoxia Zhu
Division of Rheumatology, Shanghai Medical College, Fudan University, Huashan Hospital, Shanghai, China
PLoS ONE 6:e27081. 2011..It suggests that Sirt1 is an efficient target for regulation of inflammation. This study provides insight on treatment of inflammation-related diseases...
- Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylationHeehyoung Lee
Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
Proc Natl Acad Sci U S A 109:7765-9. 2012..These findings also provide a rationale for targeting acetylated STAT3 for chemoprevention and cancer therapy...
- Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinusJulia Marchal
Mecanismes Adaptatifs et Evolution, UMR 7179 Centre National de la Recherche Scientifique, Museum national d histoire naturelle, Brunoy, France
PLoS ONE 7:e34289. 2012..These results suggest that both CR and RSV have beneficial effects on metabolic alterations, although these effects are different in amplitude between the two anti-aging treatments and potentially rely on different metabolic changes...
- Resveratrol: a review of preclinical studies for human cancer preventionMohammad Athar
Department of Dermatology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street VC15 204, New York, NY 10032, USA
Toxicol Appl Pharmacol 224:274-83. 2007..This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations...
- Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implicationsC Alarcon de la Lastra
Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
Biochem Soc Trans 35:1156-60. 2007..The present paper is intended to provide the reader up-to-date information on the antioxidant and pro-oxidant properties of resveratrol and its clinical implications...
- Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's diseaseSaravanan S Karuppagounder
Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, United States
Neurochem Int 54:111-8. 2009..This study supports the concept that onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemo-preventive agents that protect against beta-amyloid plaque formation and oxidative stress...
- Resveratrol differentially modulates inflammatory responses of microglia and astrocytesXiaofeng Lu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
J Neuroinflammation 7:46. 2010..We investigated the capacity of resveratrol to protect microglia and astrocyte from inflammatory insults and explored mechanisms underlying different inhibitory effects of resveratrol on microglia and astrocytes...
- AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrolJee Hyun Um
Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Diabetes 59:554-63. 2010..Here, we use mice deficient in AMPKalpha1 or -alpha2 to determine whether the metabolic effects of resveratrol are mediated by AMPK...
- Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transitionSharmila Shankar
Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
PLoS ONE 6:e16530. 2011..The objectives of this study were to examine the molecular mechanisms by which resveratrol inhibits stem cell characteristics of pancreatic CSCs derived from human primary tumors and Kras(G12D) transgenic mice...
- Resveratrol prevents monocrotaline-induced pulmonary hypertension in ratsAnna Csiszar
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Hypertension 54:668-75. 2009..Our studies show that resveratrol exerts anti-inflammatory, antioxidant, and antiproliferative effects in the pulmonary arteries, which may contribute to the prevention of pulmonary hypertension...
- Multiple molecular targets of resveratrol: Anti-carcinogenic mechanismsMohammad Athar
Departments of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, NY 10032, USA
Arch Biochem Biophys 486:95-102. 2009..This review summarizes in vitro mechanistic data available for resveratrol and discusses new potential anti-cancer targets and the antiproliferative mechanisms of resveratrol...
- SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signalingJennifer Chen
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
J Biol Chem 280:40364-74. 2005..They also implicate SIRT1 in this pathway and highlight the therapeutic potential of resveratrol and other sirtuin-activating compounds in Alzheimer disease...
- Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implicationsCatalina Alarcón de la Lastra
Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
Mol Nutr Food Res 49:405-30. 2005..Also, this review is intended to provide the reader an up-date of the bioavailability and pharmacokinetics of resveratrol and its impact on lifespan...
- Resveratrol induces mitochondrial biogenesis in endothelial cellsAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 297:H13-20. 2009..Resveratrol induced mitochondrial biogenesis in the aortas of type 2 diabetic mice, suggesting the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases...
- Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenaseMahesh Thirunavukkarasu
Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut Medical Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
Free Radic Biol Med 43:720-9. 2007..Thus this study shows a novel mechanism of pharmacological preconditioning with resveratrol in the diabetic myocardium...
- Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?Philipp Saiko
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Mutat Res 658:68-94. 2008..Nonetheless, the question of whether RV or its metabolites can accumulate to bioactive levels in target organs remains to be addressed...
- Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathwayElizabeth D Brookins Danz
Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
Free Radic Biol Med 46:1589-97. 2009..Our data suggest that RV protects against DOX-induced oxidative stress through changes in mitochondrial function, specifically the Sirt1 pathway leading to cardiac cell survival...
- Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivoJesse J Smith
Sirtris, a GSK Company, 200 Technology Square, Cambridge, MA 02139, USA
BMC Syst Biol 3:31. 2009....
- Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gammaFrederic Picard
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 429:771-6. 2004..As a reduction in fat is sufficient to extend murine lifespan, our results provide a possible molecular pathway connecting calorie restriction to life extension in mammals...
- Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathwayJi Hyun Lee
Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, Korea
Diabetes 58:344-51. 2009..Because of the central role of NF-kappaB in cytokine-mediated pancreatic beta-cell damage, we postulated that SIRT1 might work in pancreatic beta-cell damage models...
- Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker ratsLeonor Rivera
Department of Pharmacology, CIBER EHD, CTS 164 Research Group, School of Pharmacy, University of Granada, Campus Universitario Cartuja s n, 18071 Granada, Spain
Biochem Pharmacol 77:1053-63. 2009..In conclusion, resveratrol improved dyslipidemia, hyperinsulinemia, hyperleptinemia and hypertension in obese Zucker rats, and produced anti-inflammatory effects in VAT, effects that seem to be mediated by AMPK activation...
- Resveratrol protects against global cerebral ischemic injury in gerbilsQun Wang
Department of Pharmacology, School of Medicine, M526 Medical Science Bldg, 1 Hospital Drive, University of Missouri Columbia, Columbia, MO 65212, USA
Brain Res 958:439-47. 2002..This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury...
- Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neuronsJ Alex Parker
Institut National de la Sante et de la Recherche Medicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, 75014 Paris, France
Nat Genet 37:349-50. 2005..Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines...
- Estrogenic and antiestrogenic properties of resveratrol in mammary tumor modelsK P Bhat
Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Cancer Res 61:7456-63. 2001..In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited. These data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer...
- Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cellsChu Yue Chen
National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, Republic of Korea
Biochem Biophys Res Commun 331:993-1000. 2005..Taken together, the above findings suggest that resveratrol augments cellular antioxidant defense capacity through induction of HO-1 via Nrf2-ARE signaling, thereby protecting PC12 cells from oxidative stress...
- Colorectal cancer chemoprevention by trans-resveratrolM Emília Juan
Departament de Fisiologia, Universitat de Barcelona, Av Joan XXIII s n, E 08028 Barcelona, Spain
Pharmacol Res 65:584-91. 2012..Lastly, the article also reviews the available data on clinical trials. Altogether, the present findings support the hypothesis that the oral administration of trans-resveratrol might contribute to the prevention of colon carcinogenesis...
- Cancer chemoprevention through dietary antioxidants: progress and promiseNaghma Khan
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
Antioxid Redox Signal 10:475-510. 2008..This research is also leading to the identification of novel cancer drug targets...
- The evidence for solid lipid nanoparticles mediated cell uptake of resveratrolK Teskac
University of Ljubljana, Faculty of Pharmacy, Askerceva 7, Ljubljana, Slovenia
Int J Pharm 390:61-9. 2010..The cytostatic effect of SLN-RSV was much more expressed than that of RSV in solution. Delivery of RSV by SLN contributes to effectiveness of RSV on decreasing cell proliferation, with potential benefits for prevention of skin cancer...
- Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotectionMerce Pallas
Facultat de Farmacia, Institut de Biomedicina IBUB, Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
Curr Neurovasc Res 6:70-81. 2009..In addition, we discuss the possibility of using resveratrol in the treatment of neurodegenerative diseases...
- Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cellsF Scarlatti
Laboratory of Biochemistry and Mol Biology, San Paolo University Hospital, Medical School, University of Milan, Milan, Italy
Cell Death Differ 15:1318-29. 2008..In conclusion, this study reveals that non-canonical autophagy induced by resveratrol can act as a caspase-independent cell death mechanism in breast cancer cells...
- Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamstersAgnes M Rimando
Natural Products Utilization Research Unit, ARS, U S Department of Agriculture, Mississippi 38677, USA
J Agric Food Chem 53:3403-7. 2005..The four stilbenes were evaluated at 1, 10, 100, and 300 microM along with ciprofibrate (positive control), for the activation of ..
- A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life spanMohan Viswanathan
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Dev Cell 9:605-15. 2005..1-mediated repression of ER stress genes. Our findings demonstrate that abu-11 and other members of its ER stress gene family are positive determinants of C. elegans life span...
- Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinusAlexandre Dal-Pan
Mecanismes Adaptatifs et Evolution, UMR 7179 Centre National de la Recherche Scientifique, Museum national d histoire naturelle, 1 avenue du petit château, Brunoy, France
Age (Dordr) 33:15-31. 2011..The RESTRIKAL study can now be safely undertaken on a long-term basis to determine whether age-associated alterations in mouse lemurs are delayed with CR and if RSV can mimic these effects...
- Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathwayD Della-Morte
Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Neuroscience 159:993-1002. 2009..In conclusion, in vivo resveratrol pretreatment confers neuroprotection similar to IPC via the SIRT1-UCP2 pathway...
- Administration of resveratrol: What formulation solutions to bioavailability limitations?A Amri
Laboratoire de Pharmacie Galenique, EA4466, Universite Paris Descartes, Sorbonne Paris Cité, Faculte des Sciences Pharmaceutiques et Biologiques, Paris, France
J Control Release 158:182-93. 2012....
- Resveratrol stimulates AMP kinase activity in neuronsBiplab Dasgupta
Departments of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:7217-22. 2007..These findings suggest that neuronal activation of AMPK by resveratrol could affect neuronal energy homeostasis and contribute to the neuroprotective effects of resveratrol...
- Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTORMeilian Liu
Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
J Biol Chem 285:36387-94. 2010..Taken together, our studies reveal that RSV inhibits leucine-stimulated mTORC1 activation by promoting mTOR/DEPTOR interaction and thus uncover a novel mechanism by which RSV negatively regulates mTOR activity...
- Resveratrol and cellular mechanisms of cancer preventionYogeshwer Shukla
Indian Institute of Toxicology Research, Lucknow, India
Ann N Y Acad Sci 1215:1-8. 2011..Here, we focus on some of the myriad pathways that resveratrol targets to exert its chemopreventive role and advocate that resveratrol holds tremendous potential as an efficient anticancer drug of the future...
- Resveratrol-induced autophagocytosis in ovarian cancer cellsAnthony W Opipari
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
Cancer Res 64:696-703. 2004....
- Resveratrol, pterostilbene, and piceatannol in vaccinium berriesAgnes M Rimando
Natural Products Utilization Research Unit, ARS, U S Department of Agriculture, P O Box 8048, University, Mississippi 38677, Agriculture and Agri Food Canada, Kentville, Nova Scotia B4N 1J5, Canada
J Agric Food Chem 52:4713-9. 2004..corymbosum and V. stamineum at levels of 138-422 ng/g dry sample. These naturally occurring stilbenes, known to be strong antioxidants and to have cancer chemopreventive activities, will add to the purported health ..
- Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cellsPo Lin Kuo
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan
Life Sci 72:23-34. 2002....
- SPECT Imaging of Abeta Plaques in BrainMei Ping Kung; Fiscal Year: 2006..The proposed agents are derivatives of stilbenes containing a p-MezN-, -SH, -SMe, -0Me or -OH group on one of the benzene rings, while radioactive iodine can be ..
- Mechanisms of Reduced Heart Failure Pathogenesis with Phytochemical IntakeSteven F Bolling; Fiscal Year: 2012..Grape phytochemicals of broad interest include anthocyanins, flavanols (catechin, epicatechin, quercetin), and stilbenes (resveratrol)...
- Pawhuskins: Potential Treatments for Stimulant Abuse.Jeffrey D Neighbors; Fiscal Year: 2010..The pawhuskins are a small set of prenylated stilbenes reported from a North American prairie plant in 2004...
- CELL AND MOLECULAR BIOLOGY OF SECRETARY CL CHANNELSDale Benos; Fiscal Year: 1993..Cl- channel; 3) immunocytochemical localization and intracellular trafficking of Cl- channels; and 4) disulfonic stilbenes as probes of reconstituted Cl- channels...
- New Phase Tags and Sorting Tags for Organic SynthesisCRAIG WILCOX; Fiscal Year: 2005..This project will study two types of protean phase tags: (1) recyclable precipitons based on stilbenes for controlling organic solubility, and (2) new protean phase tags for controlling water solubility...
- Molecular Target Focused Discovery of Anticancer DrugsGeorge R Pettit; Fiscal Year: 2010....
- Molecular Target Focused Discovery of Anticancer DrugsGEORGE PETTIT; Fiscal Year: 2007..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
- Chemoprevention of prostate cancer by resveratrolTze Chen Hsieh; Fiscal Year: 2005....
- TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATIONDIPAK DAS; Fiscal Year: 2008..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. [unreadable] [unreadable]..
- PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURYDIPAK DAS; Fiscal Year: 2009....
- MYOCARDIAL PRESERVATION DURING ISCHEMIC ARRESTDIPAK DAS; Fiscal Year: 2009..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
- Nutritional Supplements and Cancer ChemopreventionJOHN PEZZUTO; Fiscal Year: 2002..Attracting the attention of these participants should provide a valuable pedagogical experience and help to foster additional progress in the field of cancer chemoprevention. ..
- Regulation of breast cancer growth by activation peptideVaclav Vetvicka; Fiscal Year: 2006..The overall goal is to generate a pharmacological agent for breast cancer based on blockage of the autocrine growth factor activity of pCD. ..
- Hemodynamic forces regulate BMPs in coronary arteriesZoltan Ungvari; Fiscal Year: 2009..abstract_text> ..
- Does SIRT1 regulate mammalian health and longevity?JOSEPH BAUR; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Synthesis of the myrmicarin family of natural productsScott Snyder; Fiscal Year: 2005....
- Cell Cycle and COX-2 in a Mouse Model of Alzheimer'sGiulio Pasinetti; Fiscal Year: 2004....
- RADIATION AND DRUG EFFECTS ON TUMOR CELL SUBPOPULATIONSDietmar Siemann; Fiscal Year: 2001..Ultimately we hope that these approaches can be reliably developed to an extent where the use of human tumor biopsy material may lead to radiotherapy treatments more tailored to the individual patient. ..
- CYCLOOXYGENASE AND ANTI-INFLAMMATORY DRUGS IN ADGiulio Pasinetti; Fiscal Year: 2001..The outcome of the proposed studies will be immediately relevant to the design of human trials. ..
- TOTAL SYNTHESIS OF AZADIRACHTINK Nicolaou; Fiscal Year: 2008..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
- Pinitol a Natural Extract from Pine Cones and Alzheimer's DiseaseGiulio Pasinetti; Fiscal Year: 2006..abstract_text> ..
- Enabling Technologies for Combinatorial ChemistryK Nicolaou; Fiscal Year: 2005..abstract_text> ..
- Novel target proteins of resveratrol in chemopreventionJoseph Wu; Fiscal Year: 2005..abstract_text> ..
- TOTAL SYNTHESIS OF APOPTOLIDINK Nicolaou; Fiscal Year: 2004..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
- COMPLEMENT AND NEUROPROTECTION: ALZHEIMER'S DISEASEGiulio Pasinetti; Fiscal Year: 2002..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
- TOTAL SYNTHESIS OF NATURAL PRODUCTSK Nicolaou; Fiscal Year: 2002..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
- Functional synergism in prevention of hormone refractory CaP by phytochemicalsJoseph Wu; Fiscal Year: 2007..The data obtained will support the concept that combined diet-derived phytochemicals can offer easily compliant strategies for protection against HRPC. [unreadable] [unreadable] [unreadable]..
- SYNTHESIS OF ANTICANCER AGENTSK C Nicolaou; Fiscal Year: 2010..abstract_text> ..
- Prevention of Neuronal Damage in Optic NeuritisKENNETH SHINDLER; Fiscal Year: 2008..This proposal will serve as an ideal platform for the principal investigator to begin a career aimed at understanding mechanisms of optic nerve damage and its correlation to clinical findings. [unreadable] [unreadable]..
- Human Monoclonal Antibodies against Botulinum ToxinsKim Janda; Fiscal Year: 2007..The proposed research provides a foundation for the use of human IgGs against BoNTs by military personnel during warfare or the general public in the event of bioterrorist activity. ..
- International Trace Elements ConferenceJanet King; Fiscal Year: 2002..The purpose of this proposal is to seek funding for the travel of selected speakers, young investigator awards, and publication of the proceedings. ..
- Mechanism Based Chemoprevention of CancerNanjoo Suh; Fiscal Year: 2005..My long-term goal is to become an independent investigator who can contribute to the entire process of making basic scientific knowledge effective in preventing cancer in men and women. ..
- NAD+ control of transcriptional silencing and longevityDavid Sinclair; Fiscal Year: 2007..As far as we are aware, our approach to understanding this fundamental regulatory network is unique. [unreadable] [unreadable]..
- Ferroportin and iron export from the macrophageMitchell Knutson; Fiscal Year: 2007..abstract_text> ..
- Evaluation of resveratrol and curcumin as therapeutics against high-risk leukemiaSUSAN ZUNINO; Fiscal Year: 2008..These studies will provide information about whether the plant antioxidants resveratrol and curcumin may be novel and efficient alternatives for the treatment of high-risk leukemia. [unreadable] [unreadable] [unreadable]..
- 2009 Biology of Aging Gordon Research ConferenceDavid Sinclair; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ROLE OF CHROMATIN IN HIV TRANSCRIPTIONAL REGULATIONERIC M VERDIN; Fiscal Year: 2010..These experiments have the potential of identifying novel factors mediating HIV transcriptional regulation that could be targeted therapeutically in the future. ..
- PG receptors in controling excitotoxicity in aging brainSYLVAIN DORE; Fiscal Year: 2008..abstract_text> ..
- Chk2 as a target for regulating senescence in skin neoplasiaArianna Kim; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Multifunctional Antioxidants as Anti-Cataract AgentsPeter Kador; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Yeast screens for genetic & chemical mimetics of CRDavid Sinclair; Fiscal Year: 2006..The longer-term goal is to test the genes and compounds we identify for their ability to extend life span in C. elegans. The knowledge gained should serve to guide searches for compounds that retard aging in mammals. ..
- A Protein-Polymer Approach to Neural Tissue RegenerationKim Janda; Fiscal Year: 2005..We envisage that the initial studies described herein will serve as the foundation for further studies in our laboratory in the design and chemical synthesis of biomimetic tissue regeneration matrices. ..
- Resveratrol, Mechanism of NeuroprotectionSYLVAIN DORE; Fiscal Year: 2005..abstract_text> ..
- WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCHRichard Miller; Fiscal Year: 2004....
- The Effects of Resveratrol on PresbyacusisMichael Seidman; Fiscal Year: 2004..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
- GENETICS OF AGE SENSITIVE TRAITS IN MICERichard Miller; Fiscal Year: 2003..At best, the program may permit the localization of loci that influence multiple age-sensitive domains and are thus plausible candidates for genes that regulate the rate of aging per se. ..
- CATALYTIC ANTIBODIESKim Janda; Fiscal Year: 2002..Access to new tailor-made antibody catalysts would advance the field and shed light on enzyme mechanisms and evolution, and provide potentially valuable immunological reagents for use in medicine and industry. ..
- MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIASTEPHEN ALWAY; Fiscal Year: 2001....
- Integrated Instrumentation for ProteomicsHelen Kim; Fiscal Year: 2002....
- IRON SUPPLEMENTS AND ZINC IN PREGNANCY AND LACTATIONJanet King; Fiscal Year: 2001..Results from this comprehensive, longitudinal study will provide new data on the effects of iron supplementation on zinc utilization during pregnancy and lactation. ..
- FLAVONOID BIOAVAILABILITY IN HUMANS-CELLULAR STUDIESThomas Walle; Fiscal Year: 2005..The findings from the proposed studies should help us understand the bioavailability of the flavonoids, facilitating optimization of the chemopreventive utility of these natural or synthetic compounds. ..
- Neuroprotective mechanisms of EGb-761SYLVAIN DORE; Fiscal Year: 2005..It could provide new pathways to support the theory that EGb could provide brain's resistance in conditions of ischemia and aged-related dementia. ..
- Chemoprevention of cancer by nuclear receptor ligandsNanjoo Suh; Fiscal Year: 2005..The goal of this proposal is to develop novel ligands for the vitamin D receptor as potential chemopreventive agents that can ultimately be used to prevent breast cancer. ..
- High-Throughput Identification of BoNT InhibitorsKim Janda; Fiscal Year: 2005..Furthermore, these studies may provide new pharmacophores which can be rapidly translated into novel drugs capable of treating BoNT exposure. ..
- Synthesis through N-Acylnitrenium Ion CyclizationDUNCAN WARDROP; Fiscal Year: 2006..abstract_text> ..
- Catalytic Antibodies as Therapy for Drug AddictionKim Janda; Fiscal Year: 2006..unreadable] [unreadable]..
- Repair of Chronially Injured Hippocampus by GraftsAshok Shetty; Fiscal Year: 2006..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
- Cell-Penetrating Peptide Agents for Cancer TherapyKim Janda; Fiscal Year: 2006..unreadable] [unreadable]..
- Human Monoclonal IgG for Protection against AnthraxKim Janda; Fiscal Year: 2006..We believe all experiments, both established and novel, will provide valuable information about the future potential of passive immunization as a treatment and/or prophylaxis for anthrax. [unreadable] [unreadable]..
- Behavior of Stem Cells in the Lesioned Aging HippocampusAshok Shetty; Fiscal Year: 2006..abstract_text> ..
- MOLECULAR ORIGIN OF CANCER--CATECHOL/SEMIQUINOE/QUINONEErcole Cavalieri; Fiscal Year: 2003..In addition, we will identify biomarkers for use in diagnosis and in studies of prevention of breast cancer and other diseases. ..
- Regulation of cholesterol catabolism by bile acidsJONGSOOK KEMPER; Fiscal Year: 2008..abstract_text> ..
- SPECIES SUSCEPTIBILITY TO DIABETIC COMPLICATIONSKENNETH GABBAY; Fiscal Year: 2002....
- ALDO/KETO REDUCTASES AND DIABETIC COMPLICATIONSKENNETH GABBAY; Fiscal Year: 2001....
- PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUMMark Phillippe; Fiscal Year: 2002..s. ..
- Targeting Akt/NF-kappa beta for Pancreatic Cancer TherapyFazlul Sarkar; Fiscal Year: 2007..These results will provide mechanistic as well as pre-clinical data in support of our hypotheses and may open new and novel avenues for the treatment of human pancreatic cancer. ..
- Molecular Orgin Cancer--Catechol Estrogen 3 4 QuinonesErcole Cavalieri; Fiscal Year: 2004..The knowledge acquired from these studies will be essential for developing preventive strategies. ..
- Thrombin-Stimulated Intrauterine Signaling PathwayMark Phillippe; Fiscal Year: 2007..These studies are anticipated to significantly improve our understanding of the mechanisms underlying preterm labor in the presence of intrauterine infection. ..