benzyl compounds

Summary

Top Publications

  1. ncbi Asaricin, the main component of Ocotea opifera Mart. essential oil
    D Lorenzo
    Catedra de Farmacognosia y Productos Naturales, , General Montevideo, Uruguay
    Nat Prod Lett 15:163-70. 2001
  2. ncbi Recognition of alpha-amino acid derivatives by N,N'-dibenzylated S,S-(+)-tetrandrine
    Karen Ochoa Lara
    Departamento de Investigacion en Polimeros y Materiales, Universidade de Sonora, Mexico
    Org Biomol Chem 2:1712-8. 2004
  3. ncbi Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent
    Chi Kuan Ho
    Department of Medical Research and Education, Taipei Veterans General Hospital, Shih Pai, Taipei, Taiwan, 11217, ROC
    Cancer Invest 21:729-36. 2003
  4. ncbi Developmental toxicity of UV filters and environmental exposure: a review
    Margret Schlumpf
    GREEN Tox and Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Int J Androl 31:144-51. 2008
  5. ncbi Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage
    Tzu Hsuan Chen
    Pharmacological Institute and School of Pharmacy, College of Medicine, National Taiwan University, Taiwan, Republic of China
    Clin Cancer Res 14:4250-8. 2008
  6. ncbi Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia
    Patrizia Oliva
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, The Second University of Naples, Italy
    Eur J Pharmacol 530:40-7. 2006
  7. ncbi Novel selective and metabolically stable inhibitors of anandamide cellular uptake
    Giorgio Ortar
    Dipartimento di Studi Farmaceutici, Universita La Sapienza, P le A Moro 5, 00185, Roma, Italy
    Biochem Pharmacol 65:1473-81. 2003
  8. ncbi Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry
    Jochen Beyer
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, Homburg Saar, Germany
    Ther Drug Monit 28:568-75. 2006
  9. ncbi Toxicological evaluation of myristicin
    H Hallstrom
    Division of Toxicology, National Food Administration, Uppsala, Sweden
    Nat Toxins 5:186-92. 1997
  10. ncbi Risk assessment of topically applied products
    Tue Søeborg
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 corrected Copenhagen corrected Denmark
    Toxicology 236:140-8. 2007

Research Grants

Detail Information

Publications207 found, 100 shown here

  1. ncbi Asaricin, the main component of Ocotea opifera Mart. essential oil
    D Lorenzo
    Catedra de Farmacognosia y Productos Naturales, , General Montevideo, Uruguay
    Nat Prod Lett 15:163-70. 2001
    ..The structure has been established by a study of its mono- and bidimensional NMR spectra and mass spectrometry...
  2. ncbi Recognition of alpha-amino acid derivatives by N,N'-dibenzylated S,S-(+)-tetrandrine
    Karen Ochoa Lara
    Departamento de Investigacion en Polimeros y Materiales, Universidade de Sonora, Mexico
    Org Biomol Chem 2:1712-8. 2004
    ..8. The binding specificity of DBT is rationalized on the basis of molecular mechanics calculations...
  3. ncbi Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent
    Chi Kuan Ho
    Department of Medical Research and Education, Taipei Veterans General Hospital, Shih Pai, Taipei, Taiwan, 11217, ROC
    Cancer Invest 21:729-36. 2003
    ..Thus, the precise nature of its cytotoxic mechanism remains to be determined. Our results in this study imply that moscatilin is potentially efficacious for chemoprevention and/or chemotherapy against some types of cancer...
  4. ncbi Developmental toxicity of UV filters and environmental exposure: a review
    Margret Schlumpf
    GREEN Tox and Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Int J Androl 31:144-51. 2008
    ..7 mg/kg for 4-MBC and 0.24/0.07 mg/kg for 3-BC. Molecular endpoints were affected by the lowest doses studied. Our data indicate that the potential risk posed by endocrine active UV filters warrants further investigations...
  5. ncbi Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage
    Tzu Hsuan Chen
    Pharmacological Institute and School of Pharmacy, College of Medicine, National Taiwan University, Taiwan, Republic of China
    Clin Cancer Res 14:4250-8. 2008
    ..To study the effect of moscatilin (purified from the stem of orchid Dendrobrium loddigesii) on the proliferation of human colorectal cancer HCT-116 cells in vitro and in vivo...
  6. ncbi Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia
    Patrizia Oliva
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, The Second University of Naples, Italy
    Eur J Pharmacol 530:40-7. 2006
    ..These data show that periaqueductal grey prostaglandin receptor stimulation increased formalin-induced nociceptive response in the late phase by increasing glutamate release and by producing a biphasic change in GABA release...
  7. ncbi Novel selective and metabolically stable inhibitors of anandamide cellular uptake
    Giorgio Ortar
    Dipartimento di Studi Farmaceutici, Universita La Sapienza, P le A Moro 5, 00185, Roma, Italy
    Biochem Pharmacol 65:1473-81. 2003
    ..Unlike other compounds of the same type, OMDM-1, OMDM-2, and OMDM-6 were very stable to enzymatic hydrolysis by rat brain homogenates...
  8. ncbi Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry
    Jochen Beyer
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, Homburg Saar, Germany
    Ther Drug Monit 28:568-75. 2006
    ....
  9. ncbi Toxicological evaluation of myristicin
    H Hallstrom
    Division of Toxicology, National Food Administration, Uppsala, Sweden
    Nat Toxins 5:186-92. 1997
    ..It is, however, at present not possible to make a complete risk assessment, as studies regarding genotoxicity and chronic toxicity, including reproductive toxicity and carcinogenicity, are still lacking...
  10. ncbi Risk assessment of topically applied products
    Tue Søeborg
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 corrected Copenhagen corrected Denmark
    Toxicology 236:140-8. 2007
    ....
  11. ncbi Nutmeg (myristicin) poisoning--report on a fatal case and a series of cases recorded by a poison information centre
    U Stein
    Department of Legal Medicine Erfurt, Institute of Legal Medicine, Friedrich-Schiller University, Jena, Germany
    Forensic Sci Int 118:87-90. 2001
    ..In one of these cases, a myristicin blood level of 2 microg/ml was measured 8h after ingestion of two to three tablespoonful of nutmeg powder (approx. 14-21 g, or 280-420 mg/kg)...
  12. ncbi A placebo-controlled trial of itopride in functional dyspepsia
    Gerald Holtmann
    Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital and University of Adelaide, Adelaide, SA, Australia
    N Engl J Med 354:832-40. 2006
    ..The treatment of patients with functional dyspepsia remains unsatisfactory. We assessed the efficacy of itopride, a dopamine D2 antagonist with anti-acetylcholinesterase [corrected] effects, in patients with functional dyspepsia...
  13. ncbi Stimulatory action of itopride hydrochloride on colonic motor activity in vitro and in vivo
    Tadashi Tsubouchi
    Pharmacology Laboratory, GPRD Discovery, Abbott Japan Japan
    J Pharmacol Exp Ther 306:787-93. 2003
    ..Therefore, itopride may be a useful drug for the treatment of functional bowel disorders such as functional constipation...
  14. ncbi Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells
    Yi Nan Liu
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Shock 33:70-5. 2010
    ..7. Furthermore, the inhibition of moscatilin seemed to be dependent on the repression of HIF-1alpha accumulation and NF-kappaB activation...
  15. ncbi Randomised, double-blind, comparative study to evaluate the efficacy and safety of ganaton (itopride hydrochloride) and mosapride citrate in the management of functional dyspepsia
    Deepak N Amarapurkar
    Bombay Hospital and Medical Research Centre, Mumbai
    J Indian Med Assoc 102:735-7, 760. 2004
    ..7%) (p < 0.05) and poor in 0 (0%) versus 6 (20%) patients respectively. It may be concluded that ganaton (itopride hydrochloride) is superior in efficacy and safety over mosapride citrate in the management of functional dyspepsia...
  16. pmc Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase
    Cecilia J Hillard
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Neurosci 33:18-24. 2007
    ....
  17. ncbi Synthesis and physicochemical characterization of two gadolinium(III) TTDA-like complexes and their interaction with human serum albumin
    Ming Hung Ou
    Faculty of Medicinal and Applied Chemistry, Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Republic of China
    Inorg Chem 45:244-54. 2006
    ..Finally, as measured by the Zn(II) transmetalation process, the kinetic stability of these Gd(III) complexes are significantly higher than that of [Gd(DTPA-BMA)(H(2)O)]...
  18. ncbi Synthesis of 6-substituted 9-benzyl-8-hydroxypurines with potential interferon-inducing activity
    Kazunori Kazaoka
    Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora Higashi, Japan
    Chem Pharm Bull (Tokyo) 51:608-11. 2003
    ..Since these compounds (2-8) indicated no activity, it was found that a free amino group of 1 is required for the expression of IFN-inducing activity...
  19. ncbi The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity
    Diana Gimenez
    Departament de Quimica Organica, Facultat de Farmacia, Universitat de Valencia, 46100 Burjassot, Valencia, Spain
    Bioorg Med Chem 14:6971-8. 2006
    ..An enhanced activity was found in those derivatives whose structure contained fluorine, suggesting an increase in their hydrophobicity...
  20. ncbi Alkylalanes and methyl furanosides: regioselective O-debenzylation or acetal cleavage
    Cai Jia
    Ecole Normale Superieure, Departement de Chimie, UMR 8642 CNRS, 24 rue Lhomond, F 75005 Paris, France
    Carbohydr Res 341:2135-44. 2006
    ..Diisobutylalane (DIBAL-H) allowed an easy access to reduced open-chain compounds, whereas trimethylalane (TMAL) stereoselectively produced methylated open chain derivatives...
  21. ncbi Synthesis and in vitro antitumor activity of novel series 2-benzylthio-4-chlorobenzenesulfonamide derivatives
    J Sławiński
    Department of Chemical Technology of Drugs, Medical University of Gdansk, al Gen J Hallera 107, 80 416 Gdansk, Poland
    Eur J Med Chem 41:1180-9. 2006
    ..1 microM, TGI=0.5-0.6 microM)...
  22. ncbi Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Facolta di Farmacia, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 40:521-8. 2005
    ..In addition such substituents appear more flexible and able to take different conformations with respect to phenyl groups which have higher trend to coplanar conformations...
  23. ncbi Conformational analysis of the cis- and trans-adducts of the Pictet - Spengler reaction. Evidence for the structural basis for the C(1) - N(2) scission process in the cis- to trans-isomerization
    Dongmei Han
    Department of Chemistry, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53211, USA
    J Nat Prod 70:75-82. 2007
    ..This provides the structural basis for the carbocation-mediated intermediate in the C(1) - N(2) scission process...
  24. ncbi Solid-phase synthesis of 2,3-disubstituted benzo[b]thiophenes and benzo[b]selenophenes
    Chinh T Bui
    Iliad Chemicals Pty Ltd, c o The Department of Chemistry, La Trobe University, Bundoora, Victoria 3086, Australia
    J Comb Chem 8:163-7. 2006
    ..A concise and efficient solid-phase synthesis of benzo[b]thiophenes and benzo[b]selenophenes based on a combination of palladium-mediated coupling and iodocyclization protocols has been developed...
  25. ncbi Polymer-supported Cinchona alkaloid-derived ammonium salts as recoverable phase-transfer catalysts for the asymmetric synthesis of alpha-amino acids
    Rafael Chinchilla
    Departamento de Química Orgánica and Instituto de Síntesis Orgánica ISO, Universidad de Alicante, Apdo 99, 03080 Alicante, Spain
    Molecules 9:349-64. 2004
    ..These new polymeric catalysts can be easily recovered by simple filtration after the reaction and reused. The best ee's were achieved when Merrifield resin-anchored cinchonidinium ammonium salts were employed...
  26. ncbi Synthesis of functionalized 1,2-dihydroisoquinolines via multicomponent one-pot reaction of 2-alkynylbenzaldehyde, amine, zinc, and allylic bromide or benzyl bromide
    Ke Gao
    Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
    J Org Chem 72:8611-3. 2007
    ....
  27. ncbi Enantioselective nickel-catalyzed cross-coupling reactions of trialkynylindium reagents with racemic secondary benzyl bromides
    Jorge Caeiro
    Departamento de Quimica Fundamental, Universidade da Coruna, 15071 A Coruna, Spain
    Chemistry 14:741-6. 2008
    ..The reaction takes place efficiently in good yields and with high atom economy, as the triorganoindium reagents transfer the three organic groups attached to indium (only 40 mol % of R3In is used)...
  28. ncbi Solid-supported acids for debenzylation of aryl benzyl ethers
    Thaninee Petchmanee
    Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Vipavadee Rangsit Highway, Bangkok 10210, Thailand
    J Org Chem 71:2892-5. 2006
    ..Stoichiometric amounts of solid-supported acids in refluxing toluene with or without 4 equiv of methanol effectively provided the desired aromatic debenzylation products of various systems in moderate to excellent yields (up to 98%)...
  29. ncbi Simultaneous regioselective protection of phenyl 1-thioglucosides at the C-3 and C-6 or at the C-2 and C-6 hydroxy groups
    Yasunori Ikeda
    School of Science and Technology, Kwansei Gakuin University, 2 1 Gakuen, Sanda 669 1337, Japan
    Carbohydr Res 337:1499-501. 2002
    ..The C-2 and C-6 hydroxy groups of the alpha-thioglucoside were selectively protected with tert-butyldiphenylsilyl trifluoromethanesulfonate...
  30. ncbi Inhibition of mandelate racemase by alpha-fluorobenzylphosphonates
    Martin St Maurice
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Bioorg Med Chem Lett 13:2041-4. 2003
    ..For example, (S)-alpha-fluorobenzylphosphonate is bound with the same affinity as the substrate at pH 7.5, but this affinity is increased approximately 6-fold at pH 6.3...
  31. ncbi Development of the first potential covalent inhibitors of anandamide cellular uptake
    Aniello Schiano Moriello
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, via dei Campi Flegrei 34, 80078 Pozzuoli Napoli, Italy
    J Med Chem 49:2320-32. 2006
    ..None of the new compounds inhibited [(14)C]anandamide hydrolysis with IC(50) < 50 microM, except for 1b...
  32. ncbi Stereoselective synthesis of (E)- and (Z)-enol ethers from beta-amino aldehydes
    Jin Kyung In
    College of Pharmacy, Chungbuk National University, Cheongju 361 763, Korea
    Arch Pharm Res 30:695-700. 2007
    ..These enol ethers with the defined olefin geometry could be key building blocks for the synthesis of the medicinally impor tant compounds...
  33. ncbi N-Carbamate-assisted stereoselective synthesis of chiral vicinal amino sulfides
    Michael De Paolis
    Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif sur Yvette Cedex, France
    Org Lett 4:1235-8. 2002
    ..A double SN2 process initiated by O-5 participation of the neighboring N-carbamate group was advanced to explain the overall retention of configuration at the chiral benzylic center...
  34. ncbi 5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family
    Antonello Mai
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universita degli Studi di Roma La Sapienza, P le A Moro 5, I 00185 Roma, Italy
    Bioorg Med Chem 13:2065-77. 2005
    ....
  35. ncbi Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors
    Robert M Rzasa
    Department of Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1789, USA
    Bioorg Med Chem 15:6574-95. 2007
    ..In this investigation we present our synthetic studies toward this series of compounds and discuss their biological relevance as CDK5 inhibitors...
  36. ncbi Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism
    Jeewoo Lee
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Bioorg Med Chem 12:3411-20. 2004
    ..The conformational analysis of 1 generated three distinct conformers having different types of hydrophobic interactions, which will be utilized for exploring the active conformation of the VR1 ligand...
  37. ncbi Synthesis and aldose reductase inhibitory activities of novel O-substituted hydroxyphenylacetic acid derivatives
    Dietmar Rakowitz
    Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria
    Arch Pharm (Weinheim) 339:547-58. 2006
    ..This result demonstrates that within these series, this moiety is a useful surrogate for the 4-bromo-2-fluorobenzyl residue which can be often found in potent aldose reductase inhibitors...
  38. ncbi N-benzyl and O-benzyl compounds: a new group of synthetic auxin biomimetics
    R G Gafurov
    Institute of Physiologically Active Substances, Russian Academy of Sciences, Severnyi pr 1, Chernogolovka, Moscow Oblast, 142432 Russia
    Dokl Biol Sci 391:353-5. 2003
  39. ncbi Catalytic action of triarylstibanes: oxidation of benzoins into benzyls using triarylstibanes under an aerobic condition
    Shuji Yasuike
    Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa
    Chem Pharm Bull (Tokyo) 53:425-7. 2005
    ..The reaction should involve an oxidation-reduction cycle between stibane Sb(III) and stiborane Sb(V) under air...
  40. ncbi Indole diterpene synthetic studies. Total synthesis of (+)-nodulisporic acid F and construction of the heptacyclic cores of (+)-nodulisporic acids A and B and (-)-nodulisporic acid D
    Amos B Smith
    Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Org Chem 72:4596-610. 2007
    ....
  41. ncbi Structure of tyrolobibenzyl D and biological activity of tyrolobibenzyls from Scorzonera humilis
    Christian Zidorn
    Institut fur Pharmazie, Abteilung Pharmakognosie, Universitat Innsbruck, Austria
    Z Naturforsch C 57:614-9. 2002
    ..An evaluation of potential chemopreventive activity of 2, 2a, 4, and 4a also revealed no pronounced activity in any of the employed assaying systems...
  42. ncbi Synthesis of (+/-)-hamigeran B, (-)-hamigeran B, and (+/-)-1-epi-hamigeran B: use of bulky silyl groups to protect a benzylic carbon-oxygen bond from hydrogenolysis
    Derrick L J Clive
    Chemistry Department, University of Alberta, Edmonton, Alberta, Canada
    J Org Chem 69:2773-84. 2004
    ..Optically pure enone 73 was made by use of a Meyers' auxiliary and converted into (-)-hamigeran B with the natural absolute configuration...
  43. pmc Smaller building blocks form larger assemblies: aggregation behavior of biaryl-based dendritic facial amphiphiles
    Ashootosh V Ambade
    Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Org Chem 72:8167-74. 2007
    ....
  44. ncbi Facile and regioselective preparation of partly O-benzylated D-glucopyranose acetates via acid-mediated simultaneous debenzylation-acetolysis
    Yang Cao
    School of Science and Technology, Kwansei Gakuin University, 2 1 Gakuen, Sanda 669 1337, Japan
    Carbohydr Res 341:2219-23. 2006
    ..The key points of the preparative reactions were the control of the acid strength and choice of suitable substrates...
  45. ncbi Role of the countercation in diastereoselective alkylations of pyramidalized bicyclic serine enolates. An easy approach to alpha-benzylserine
    Gonzalo Jiménez-Osés
    Departamento de Quimica, Universidad de La Rioja, Grupo de Sintesis Quimica de La Rioja, UA CSIC, 26006 Logrono, Spain
    J Org Chem 72:5399-402. 2007
    ..Theoretical studies have been performed in order to elucidate the stereochemical outcome of the alkylation process, which occurs with total retention of configuration...
  46. ncbi Use of the benzyl mesylate for the synthesis of tetrahydrofuran lignan: syntheses of 7,8-trans, 7',8'-trans, 7,7'-cis, and 8,8'-cis-virgatusin stereoisomers
    Satoshi Yamauchi
    Faculty of Agriculture, Ehime University, 3 5 7 Tarumi, Matsuyama, Ehime 790 8566, Japan
    Biosci Biotechnol Biochem 71:2248-55. 2007
    ..The optically pure 7,8-trans, 7',8'-trans, 7,7'-cis, and 8,8'-cis-virgatusin stereoisomers were synthesized. The enantiomeric excess was >>99%...
  47. ncbi 1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)formamide
    Vijayakumar N Sonar
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington KY 40536, USA
    Acta Crystallogr C 62:o153-4. 2006
    ..8 (3) degrees. The single C-C bond linking the two carbonyl functionalities is 1.539 (4) A. Molecules are linked into a two-dimensional network by intermolecular N-H...O hydrogen bonds...
  48. ncbi (Z)-3-(1H-Indol-3-yl)-2-(3-thienyl)acrylonitrile and (Z)-3-[1-(4-tert-butylbenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile
    Vijayakumar N Sonar
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Acta Crystallogr C 61:o78-80. 2005
    ..Slight thienyl ring-flip disorder (ca 5.6%) was observed and modeled for (I)...
  49. ncbi [Analysis of 1H-NMR fingerprint in stem of Dendrobium loddigesii]
    Hai Lin Qin
    Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, China
    Zhongguo Zhong Yao Za Zhi 27:919-23. 2002
    ..To analyse the 1H-NMR finger-print of the stem of Dendrobium loddigesii...
  50. ncbi Facile deprotection of O-Cbz-protected nucleosides by hydrogenolysis: an alternative to O-benzyl ether-protected nucleosides
    David C Johnson
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    Org Lett 6:4643-6. 2004
    ..Additionally, an experiment is described that suggests the nucleobase component of a nucleoside is responsible for the sluggish hydrogenolysis of nucleosides...
  51. ncbi Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation
    Kimberly S Petersen
    Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA
    J Med Chem 50:5824-32. 2007
    ..One of these three 23-oxa analogs has transcriptional potency almost as high as that of calcitriol, even though it binds to the human vitamin D receptor only about 1% as well as calcitriol...
  52. ncbi Enantioselective syntheses of dopaminergic (R)- and (S)-benzyltetrahydroisoquinolines
    N Cabedo
    , Laboratorio de Farmacognosia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
    J Med Chem 44:1794-801. 2001
    ..Moreover, (1S)-14a inhibits [3H]dopamine uptake with high affinity. It appears that synthesis and testing of (S)-enantiomers of BTHIQ are very important for the search for new active drugs at dopamine receptors...
  53. ncbi Iron incorporated heterogeneous catalyst from rice husk ash
    Farook Adam
    School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
    J Colloid Interface Sci 304:137-43. 2006
    ..The minor products consisting of 16 di-substituted isomers were also observed in the GC-MS spectra of both catalytic products. The catalyst was found to be reusable without loss of activity and with no leaching of the metal...
  54. ncbi Lipase-catalyzed synthesis and curing of high-molecular-weight polyricinoleate
    Hiroki Ebata
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3 14 1 Hiyoshi, Yokohama 223 8522, Japan
    Macromol Biosci 7:798-803. 2007
    ..Polyricinoleate was readily cured using a dicumyl peroxide at 170 degrees C for 30 min to produce a chloroform insoluble crosslinked polyricinoleate with a hardness of 50A using durometer A...
  55. ncbi Bismuth-catalyzed benzylic oxidations with tert-butyl hydroperoxide
    Yannick Bonvin
    Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, England
    Org Lett 7:4549-52. 2005
    ..Alternatively, oxidation of methyl arenes gave the corresponding substituted benzoic acids (50-95%). Preliminary mechanistic studies were consistent with a radical mechanism rather than a bismuth(III)-bismuth(V) cycle...
  56. ncbi Efficient synthesis of the structural core of tetracyclines by a palladium-catalyzed domino Tsuji-Trost-Heck-Mizoroki reaction
    Lutz F Tietze
    Institut fur Organische und Biomolekulare Chemie, Georg August Universitat Gottingen, Tammannstrasse 2, 37077 Gottingen, Germany
    Chemistry 14:2527-35. 2008
    ..The octahydroanthracene and hexahydronaphthacene motifs are found in many natural products, for example, the tetracycline antibiotics...
  57. ncbi Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS
    Andre Rosowsky
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Med Chem 46:1726-36. 2003
    ....
  58. ncbi A new strategy for the synthesis of benzylic sulfonamides: palladium-catalyzed arylation and sulfonamide metathesis
    Jonathan B Grimm
    Department of Drug Design and Optimization, Merck Research Laboratories, Boston, Massachusetts 02115, USA
    J Org Chem 72:8135-8. 2007
    ..The broad scope of the cross-coupling process combined with a versatile sulfonamide metathesis constitutes an efficient strategy for the synthesis of various benzylic sulfonamides...
  59. ncbi Synthesis of a photoactivatable probe of the anandamide re-uptake
    Laurence Balas
    UMR CNRS 5074, Faculty of Pharmacy, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier 5, France
    Nat Prod Res 19:419-23. 2005
    ..An iodo-arylazido probe was synthesized from commercially available azelaic acid monomethyl ester, in order to shed light on the anandamide transport process...
  60. ncbi N-Substituted amino acid N'-benzylamides: synthesis, anticonvulsant, and metabolic activities
    Cecile Beguin
    Department of Chemistry, University of Houston, Houston, TX 77204 5641, USA
    Bioorg Med Chem 12:3079-96. 2004
    ..An in vitro metabolism study suggested that the structure-activity relationship pattern was due, in part, to metabolic processes that occurred at the N-terminal amine unit...
  61. ncbi Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists
    Gaetan H Ladouceur
    Department of Chemistry Research, Bayer Research Center, West Haven, CT 06516, USA
    Bioorg Med Chem Lett 12:3421-4. 2002
    ..A diastereoselective methylcopper reaction was developed to facilitate the synthesis, and single isomers were isolated with activities in the range IC(50)=10-25 nM...
  62. ncbi Synthesis and structure-activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure
    Takahiro Kuramochi
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Bioorg Med Chem 13:725-34. 2005
    ..Compound 7i was evaluated for its efficacy on ouabain-induced tonotropy and arrhythmia in a heart-failure model...
  63. ncbi Evaluation of the glycoside hydrolase activity of a Brettanomyces strain on glycosides from sour cherry (Prunus cerasus L.) used in the production of special fruit beers
    Luk Daenen
    Department of Microbial and Molecular Systems, Centre for Malting and Brewing Science, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Leuven, Belgium
    FEMS Yeast Res 8:1103-14. 2008
    ..Refermentations with whole sour cherries and with sour cherry stones demonstrated an increased formation of benzyl compounds. Thus, amygdalin was partially hydrolysed, and a large part of the benzaldehyde formed was mainly reduced to ..
  64. ncbi Synthesis and biological evaluation of first N-alkyl syn dimeric 4-aryl-1,4-dihydropyridines as competitive HIV-1 protease inhibitors
    A Hilgeroth
    Department of Pharmacy, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Strasse 4, D 06120 Halle, Germany
    Eur J Med Chem 36:367-74. 2001
    ..While the N-methyl derivatives 12 and 13 were almost inactive, with IC(50)-values of about 225 microM, the N-benzyl compounds with varied ester groups all exhibited stronger activities, with IC(50)-values of 11--12 microM for the ..
  65. ncbi Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers
    Ozden Ozel Güven
    Department of Chemistry, Zonguldak Karaelmas University, 67100 Zonguldak, Turkey
    Bioorg Med Chem Lett 17:2233-6. 2007
    ..aureus (MRSA), Escherichia coli, Candida albicans, and Candida krusei. Compound 6g exhibited the most potent antibacterial activity with lowest MIC values of 3.12 and 6.25 microg/mL against S. aureus and MRSA, respectively...
  66. ncbi Involvement of Na+/H+ exchangers in induction of cyclooxygenase-2 by vacuolar-type (H+)-ATPase inhibitors in RAW 264 cells
    Fumitaka Kamachi
    Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba Aramaki, Aoba ku, Sendai, Miyagi 980 8578, Japan
    FEBS Lett 581:4633-8. 2007
    ..These results suggested that V-ATPase inhibitors induce the expression of COX-2 via NHE-dependent and -independent pathways...
  67. ncbi Stereoselective construction of tetra-substituted tetrahydrofuran compounds from benzylic hemiacetal in the presence of H2 and a Pd catalyst: stereoselective synthesis of a stereoisomer of (-)-virgatusin and its antimicrobiological activity
    Tomofumi Nakato
    Faculty of Agriculture, Ehime University, Matsuyama, Ehime, Japan
    Biosci Biotechnol Biochem 72:197-203. 2008
    ..One of these tetrahydrofuran compounds was converted to the virgatusin stereoisomer to estimate its antimicrobiological activity...
  68. ncbi N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies
    Wenhua Chu
    Division of Radiological Sciences, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, Missouri 63110, USA
    J Med Chem 48:7637-47. 2005
    ....
  69. ncbi A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase mutant derivative highly active and stereoselective on phenylacetone and benzylacetone
    Karla I Ziegelmann-Fjeld
    Department of Biochemistry and Molecular Biology, Michigan State University, 410 Biochemistry Building, East Lansing, MI 48824 1319, USA
    Protein Eng Des Sel 20:47-55. 2007
    ..Our results suggest that (S)-2-butanol's orientation in the TbSADH*(S)-2-butanol binary complex does not reflect its orientation in the ternary enzyme-substrate-cofactor complex...
  70. ncbi Isomerization in fluorescent protein chromophores involves addition/elimination
    Jian Dong
    School of Chemistry and Biochemistry, 901 Atlantic Drive Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
    J Am Chem Soc 130:14096-8. 2008
    ..This observation may have implications for the intervention of such processes, as well as blinking and kindling, in fluorescent proteins...
  71. ncbi Different interaction motifs of dipolar S=O...C=O contacts that associate diastereomers of 2,4(6)-di-O-benzoyl-6(4)-O-{[(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-ylmethyl]sulfonyl}-myo-inositol 1,3,5-orthoacetate
    K Manoj
    Centre for Materials Characterization, National Chemical Laboratory, Pune 411 008, India
    Acta Crystallogr C 63:o555-8. 2007
    ..C=O contacts bridging the former, whereas perpendicular S=O...C=O contacts occur in the latter. The title compound, C(32)H(34)O(11)S, is chiral, owing to the presence of the camphor moiety...
  72. ncbi Perilla frutescens var. frutescens in northern Laos
    Michiho Ito
    Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo, Kyoto, 606 8501, Japan
    J Nat Med 62:251-8. 2008
    ..The farmers' indifference to the oil type of the leaf seems to leave Laotian perilla as a good genetic resource for studies of the biosynthesis of oil compounds...
  73. pmc Effect of itopride hydrochloride on the ileal and colonic motility in guinea pig in vitro
    Hyun Chul Lim
    Department of Internal Medicine, Yonsei University College of Medicine, 612 Eonjuro, Gangnam Gu, Seoul 135 720, Korea
    Yonsei Med J 49:472-8. 2008
    ..However, its prokinetic effect on the small bowel or colon has not yet been thoroughly investigated. The aim of this study was to investigate the effects of itopride on motor functions of the ileum and colon in guinea pigs...
  74. ncbi Palladium-catalyzed oxidative acetoxylation of benzylic C-H bond using bidentate auxiliary
    Long Ju
    ZJU NHU United R and D Center, Department of Chemistry, Zhejiang University, Hangzhou 310027, China
    J Org Chem 78:10821-31. 2013
    ..A broad of functionalities, such as CH3, F, Cl, Br, I, COCH3, CO2Et, SO2CH3, and NO2, were tolerated. This transformation provides easy access to 2-hydroxymethylaniline derivatives. ..
  75. ncbi New substrate analogue inhibitors of factor Xa containing 4-amidinobenzylamide as P1 residue: part 1
    Andrea Schweinitz
    Curacyte Chemistry GmbH, Winzerlaer Str 2, D 07745 Jena, Germany
    Med Chem 2:349-61. 2006
    ..The structures of two inhibitors in complex with human fXa were solved by X-ray crystallography...
  76. ncbi General and efficient copper-catalyzed amidation of saturated C-H bonds using N-halosuccinimides as the oxidants
    Xiaowei Liu
    Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China
    J Org Chem 73:6207-12. 2008
    ..The protocol uses inexpensive and readily available CuBr/ N-halosuccinimide (NBS or NCS) as the catalyst/oxidant, so it provides practical applications for synthesis of various amides via C-H activation...
  77. ncbi [Effect of prokinetic agents on the electrical activity of stomach and duodenum in rats]
    Fujun Li
    Department of Gastroenterology, Xiangya Hospital, Central South Uinversity, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 34:599-602. 2009
    ..To determine the effect of prokinetic agents such as domperidone, mosapride, clarithromycin, and itopride on the electrical activity of the stomach and duodenum in SD rats,and also to explore the mechanism...
  78. ncbi Two new C-benzylated dihydrochalcone derivatives from the leaves of Melodorum siamensis
    Uma Prawat
    Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket, Thailand
    Planta Med 79:83-6. 2013
    ..Compounds 1, 2, and 13 exhibited strong cytotoxicity against human tumor cell lines KB and NCI-H187, with IC50 values in the range of 0.66-7.16 µg/mL...
  79. ncbi Novel benzyl-substituted N-heterocyclic carbene-silver acetate complexes: synthesis, cytotoxicity and antibacterial studies
    Siddappa Patil
    Conway Institute of Biomolecular and Biomedical Research, Centre for Synthesis and Chemical Biology CSCB, UCD School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Metallomics 3:74-88. 2011
    ..6), 10.8 (±1.9), 24.2 (±1.8) and 13.6 (±1.0) μM, respectively. These values represent improved cytotoxicity against Caki-1, most notably for 4c, which is a three times more cytotoxic than cisplatin (IC₅₀ value = 3.3 μM) itself...
  80. ncbi Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion
    Hitomi Tsuiji
    Pathology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Glycobiology 13:521-7. 2003
    ..The carbohydrate-directed approach to the regulation of dysadherin expression might be a new strategy for cancer therapy...
  81. ncbi Quantitation of itopride in human serum by high-performance liquid chromatography with fluorescence detection and its application to a bioequivalence study
    Sonu Sundd Singh
    Zydus Research Centre, Sarkhej Bavla N H No 8A, Moraiya, Ahmedabad 382213, India
    J Chromatogr B Analyt Technol Biomed Life Sci 818:213-20. 2005
    ..0 days at -70+/-5 degrees C and for 24.0 h at ambient temperature (25+/-5 degrees C). The method was successfully applied to the bioequivalence study of itopride in healthy, male human subjects...
  82. ncbi A new automated method to assess the rat recognition memory: validation of the method
    Caroline Chambon
    In Vivo Pharmacology, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, D 60318 Frankfurt am Main, Germany
    Behav Brain Res 222:151-7. 2011
    ....
  83. ncbi A general palladium-catalyzed carbonylative synthesis of chromenones from salicylic aldehydes and benzyl chlorides
    Xiao Feng Wu
    Department of Chemistry, Zhejiang Sci Tech University, Xiasha Campus, Hangzhou, Zhejiang Province 310018 P R China Leibniz Institut für Katalyse an der Universität Rostock e V Albert Einstein Strasse 29a, 18059 Rostock Germany
    Chemistry 19:12245-8. 2013
    ..In the presence of a palladium catalyst, various coumarins were produced in good to excellent yields...
  84. ncbi A novel technology for improving hair setting ability and its mechanism
    Masayoshi Nojiri
    Kao Corporation, 2 1 3, Bunka, Sumida ku, Tokyo 131 8501, Japan
    J Cosmet Sci 55:S151-3. 2004
  85. pmc Nickel-catalyzed Heck-type reactions of benzyl chlorides and simple olefins
    Ryosuke Matsubara
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 133:19020-3. 2011
    ....
  86. ncbi First derivatives of myo-inositol 1,4,6-trisphosphate modified at positions 2 and 3: structural analogues of D-myo-inositol 1,4,5-trisphosphate
    Graeme Horne
    Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Carbohydr Res 339:51-65. 2004
    ....
  87. ncbi Optimized ultrasonic assisted extraction-dispersive liquid-liquid microextraction coupled with gas chromatography for determination of essential oil of Oliveria decumbens Vent
    Hassan Sereshti
    School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
    J Chromatogr A 1218:4593-8. 2011
    ..2-29 ng mL(-1), 1-2100 ng mL(-1) and 0.995-0.998, respectively. The main components of the essential oil were: thymol (47.06%), carvacrol (23.31%), gamma-terpinene (18.94%), p-cymene (8.71%), limonene (0.76%) and myristicin (0.63%)...
  88. ncbi Encapsulation of Fe(III) and Cu(II) complexes in NaY zeolite
    Sueli M Drechsel
    Departamento de Quimica, Universidade Federal do Parana, Jardim das Américas s n, CEP 81531 990 CP 19081, Curitiba, PR, Brazil
    J Colloid Interface Sci 277:138-45. 2004
    ..The EPR spectra of the solids show signals at g = 2.0, which was attributed to an Fe-Fe interaction from the noncoordinated atoms, and g = 4.3 attributed to iron (III) in a rhombic geometry...
  89. ncbi A cell-based screen for drugs to treat Huntington's disease
    Charity T Aiken
    Departments of Physiological Science and Neurology, Brain Research Institute, University of California, Los Angeles, CA 90095, USA
    Neurobiol Dis 16:546-55. 2004
    ..We believe these compounds, and others in our hit list, are appealing candidates for further investigation. Additionally, this assay is amenable to scaling up to screen additional compounds for treating Huntington's disease...
  90. ncbi Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase
    Concepción González-Bello
    Departamento de Química Orgánica y Unidad Asociada al C S I C, Facultad de Quimica, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    J Med Chem 46:5735-44. 2003
    ..The binding modes of the synthesized analogues in the active site were studied by molecular docking with GOLD 2.0...
  91. ncbi In vitro accelerated mass propagation and ex vitro evaluation of Aloe vera L. with aloin content and superoxide dismutase activity
    Saikat Gantait
    Department of Biotechnology, Instrumentation and Environmental Science, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, W B 741252, India
    Nat Prod Res 25:1370-8. 2011
    ..Morphologically, in vitro generated plants performed better than conventionally propagated plants; nevertheless the similarity in aloin content, gel content and superoxide dismutase activity was corroborated...
  92. ncbi C-H···X (X = O, N or π) interactions in benzyl carbamate
    Ignasi Mata
    Institut de Ciencia de Materials de Barcelona ICMAB CSIC, Bellaterra, Spain
    Acta Crystallogr C 68:o114-8. 2012
    ..According to the PIXEL analysis, combinations of C-H...X (X = O, N or π) interactions are comparable in energy with hydrogen bonding. These interactions are necessary for explaining the geometry and the assembly of the layers...
  93. ncbi GC-MS and GC-IRD studies on the six-ring regioisomeric dimethoxybenzylpiperazines (DMBPs)
    Karim M Abdel-Hay
    Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA
    Drug Test Anal 5:560-72. 2013
    ..Gas chromatography coupled with time-of-flight mass spectrometric detection (GC-TOF) provided an additional means of confirmation of the elemental composition of the major fragment ions in the mass spectra of these compounds...
  94. ncbi Reactions of the cumyloxyl and benzyloxyl radicals with strong hydrogen bond acceptors. Large enhancements in hydrogen abstraction reactivity determined by substrate/radical hydrogen bonding
    Michela Salamone
    Dipartimento di Scienze e Tecnologie Chimiche, Universita Tor Vergata, Via della Ricerca Scientifica, 1 I 00133 Rome, Italy
    J Org Chem 77:10479-87. 2012
    ....
  95. ncbi Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis
    Y Persidsky
    The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, 985215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 114:57-68. 2001
    ..These findings demonstrate that reduction of brain inflammatory responses, independent of viral replication, can affect HIVE pathology in an animal model system of disease...
  96. ncbi Differential distribution of sialic acid in alpha2,3 and alpha2,6 linkages in the apical membrane of cultured epithelial cells and tissues
    F Ulloa
    Unitat de Biologia Cel.lular i Molecular, , Universitat Pompeu Fabra, Barcelona, Spain
    J Histochem Cytochem 49:501-10. 2001
    ..e., alpha2,3 is preferred to alpha2,6 in the apical membrane, and (c) IMIM-PC-1 cells are a good model in which to study the regulation of the levels and distribution of sialic acids...
  97. ncbi Review of postoperative ileus
    H Kehlet
    Hvidovre University Hospital, Department of Surgical Gastroenterology, DK 2650, Copenhagen, Denmark
    Am J Surg 182:3S-10S. 2001
    ..Future studies, including those incorporating investigational agents, such as kappa-opioid agonists and peripheral mu-opioid antagonists, into a multimodal regimen, may offer new treatment options to further impact POI duration...
  98. ncbi One-pot thioetherification of aryl halides with thiourea and benzyl bromide in water catalyzed by Cu-grafted furfural imine-functionalized mesoporous SBA-15
    John Mondal
    Department of Materials Science, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
    Chem Commun (Camb) 48:8000-2. 2012
    ....
  99. ncbi Development of the carboxamide protecting group, 4-(tert-butyldimethylsiloxy)-2-methoxybenzyl
    Kazuhiro Muranaka
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Org Chem 76:9278-93. 2011
    ..An application of this group to simple carboxamide groups, as well as to more complex and acid-sensitive adenosine derivatives containing a cyclophane scaffold, was also demonstrated...
  100. ncbi Effects of a naturally occurring and a synthetic synergist on toxicity of three insecticides and a phytochemical to navel orangeworm (Lepidoptera: Pyralidae)
    Guodong Niu
    Department of Entomology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Econ Entomol 105:410-7. 2012
    ..In addition, this study demonstrates that in A. transitella the insect growth regulator methoxyfenozide is not detoxified by P450s...
  101. ncbi Diastereoselective synthesis of 6-trifluoromethyl-5,6-dihydropyrans via phosphine-catalyzed [4 + 2] annulation of α-benzylallenoates with ketones
    Tong Wang
    Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
    Org Lett 12:4168-71. 2010
    ..The highly diastereoselective synthesis of 6-trifluoromethyl-5,6-dihydropyrans was realized by the phosphine-catalyzed [4 + 2] annulation of ethyl α-benzylallenoates and trifluoromethyl ketones...

Research Grants18

  1. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  2. Gender differences in the interactions between endocannabinoids and stress
    Cecilia Hillard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  3. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
    ..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..
  4. Calcification of Elastin: Mechanisms and Prevention
    Naren Vyavahare; Fiscal Year: 2008
    ..Long-term objective of our program is to understand the mechanistic pathways of elastin calcification so that it can be prevented or reversed. The following specific aims will be pursued in this continuation program. ..
  5. MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2007
    ..The results will have important implications for the therapeutic utility of these "agonist antiemetics". [unreadable] [unreadable]..
  6. TREATMENT OF AORTIC ANEURYSMS
    Naren Vyavahare; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Effect of Alcohol on HIV-1 Immune Responses & BBB Damage
    Yuri Persidsky; Fiscal Year: 2004
    ..The ability to use an in vitro BBB and an in vivo animal model will help in defining mechanisms of disease progression in the setting of alcohol abuse. ..
  8. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  9. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2005
    ..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
  10. Mechanism of Anticarcinigenic Effects of Myristicin
    HASSAN AHMAD; Fiscal Year: 2004
    ..The results are expected to help us understand the Phase-II enzyme induction by myristicin and its potential in developing pharmacologically effective dietary strategies for cancer chemoprevention. ..
  11. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  12. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
    ..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
  13. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  14. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  15. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  16. SYNTHESIS OF MDR REVERSING POLYENES
    MERRITT ANDRUS; Fiscal Year: 2003
    ..This is an important first step toward a molecular understanding of the unique recognition properties, transport mechanism of Pgp, and will further facilitate the design of new, more potent reversal agents. ..
  17. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..