benzhydryl compounds

Summary

Summary: Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.

Top Publications

  1. pmc Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Health Perspect 116:39-44. 2008
  2. ncbi Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents
    Leonardo Trasande
    Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA
    JAMA 308:1113-21. 2012
  3. ncbi Human exposure to bisphenol A (BPA)
    Laura N Vandenberg
    Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
    Reprod Toxicol 24:139-77. 2007
  4. pmc Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    Environ Health Perspect 118:1055-70. 2010
  5. ncbi Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
    JAMA 300:1303-10. 2008
  6. pmc Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice
    Nicolas J Cabaton
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Environ Health Perspect 119:547-52. 2011
  7. ncbi Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    J Steroid Biochem Mol Biol 127:27-34. 2011
  8. pmc Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Endocr Rev 30:75-95. 2009
  9. pmc Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:739-45. 2012
  10. pmc Urinary bisphenol A and obesity: NHANES 2003-2006
    Jenny L Carwile
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Environ Res 111:825-30. 2011

Detail Information

Publications273 found, 100 shown here

  1. pmc Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Health Perspect 116:39-44. 2008
    ..Bisphenol A (BPA) and 4-tertiary-octylphenol (tOP) are industrial chemicals used in the manufacture of polycarbonate plastics and epoxy resins (BPA) and nonionic surfactants (tOP). These products are in widespread use in the United States...
  2. ncbi Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents
    Leonardo Trasande
    Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA
    JAMA 308:1113-21. 2012
    ..In adults, elevated urinary BPA concentrations are associated with obesity and incident coronary artery disease. BPA exposure is plausibly linked to childhood obesity, but evidence is lacking to date...
  3. ncbi Human exposure to bisphenol A (BPA)
    Laura N Vandenberg
    Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
    Reprod Toxicol 24:139-77. 2007
    ..The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models...
  4. pmc Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    Environ Health Perspect 118:1055-70. 2010
    ..Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. Importantly, results from a large number of biomonitoring studies are at odds with the results from two toxicokinetic studies...
  5. ncbi Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
    JAMA 300:1303-10. 2008
    ..Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans...
  6. pmc Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice
    Nicolas J Cabaton
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Environ Health Perspect 119:547-52. 2011
    ..Perinatal exposure to low-doses of bisphenol A (BPA) results in alterations in the ovary, uterus, and mammary glands and in a sexually dimorphic region of the brain known to be important for estrous cyclicity...
  7. ncbi Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    J Steroid Biochem Mol Biol 127:27-34. 2011
    ..Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging...
  8. pmc Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Endocr Rev 30:75-95. 2009
    ....
  9. pmc Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:739-45. 2012
    ..Gestational phthalate and bisphenol A (BPA) exposure may increase the risk of adverse maternal/child health outcomes, but there are few data on the variability of urinary biomarkers before and during pregnancy...
  10. pmc Urinary bisphenol A and obesity: NHANES 2003-2006
    Jenny L Carwile
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Environ Res 111:825-30. 2011
    ..We hypothesized that urinary BPA concentrations would be positively associated with general and central obesity...
  11. pmc Impact of early-life bisphenol A exposure on behavior and executive function in children
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Harvard University, Boston, MA 02130, USA
    Pediatrics 128:873-82. 2011
    ..To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations...
  12. pmc Temporal variability and predictors of urinary bisphenol A concentrations in men and women
    Shruthi Mahalingaiah
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, 665 Huntington Avenue, Boston, MA 02115, USA
    Environ Health Perspect 116:173-8. 2008
    ..Bisphenol A (BPA) is used to manufacture polymeric materials, such as polycarbonate plastics, and is found in a variety of consumer products. Recent data show widespread BPA exposure among the U.S. population...
  13. pmc Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice
    Thiago M Batista
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, Sao Paulo, Brazil
    PLoS ONE 7:e33814. 2012
    ..Thus, our findings support the notion that BPA can be considered a risk factor for the development of type 2 diabetes...
  14. pmc Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: relevance for human exposure
    Julia A Taylor
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 119:422-30. 2011
    ..We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration of BPA and compared findings in mice and monkeys with prior published data in women...
  15. ncbi Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat diet
    Jie Wei
    Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Endocrinology 152:3049-61. 2011
    ..High-fat diet intake is a trigger that initiates adverse metabolic effects of BPA...
  16. pmc Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 119:983-8. 2011
    ..Therefore, there is considerable within-person and between-person variability of BPA concentrations in spot urine samples. However, no information exists on the within-day variability of urinary BPA concentrations...
  17. pmc Bisphenol A: Perinatal exposure and body weight
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    Mol Cell Endocrinol 304:55-62. 2009
    ..The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed...
  18. pmc Perinatal exposure to bisphenol a alters early adipogenesis in the rat
    Emmanuel Somm
    Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Environ Health Perspect 117:1549-55. 2009
    ..The causes of the current obesity pandemic have not been fully elucidated. Implication of environmental endocrine disruptors such as bisphenol A (BPA) on adipose tissue development has been poorly investigated...
  19. pmc Comparison of serum bisphenol A concentrations in mice exposed to bisphenol A through the diet versus oral bolus exposure
    Paizlee T Sieli
    Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Environ Health Perspect 119:1260-5. 2011
    ..Bisphenol A (BPA) is a widely produced endocrine-disrupting chemical. Diet is a primary route of exposure, but internal exposure (serum concentrations) in animals and humans has been measured only after single oral bolus administration...
  20. pmc Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response
    Jason G Bromer
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    FASEB J 24:2273-80. 2010
    ..Permanent epigenetic alteration of ERE sensitivity to estrogen may be a general mechanism through which endocrine disruptors exert their action...
  21. pmc Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 119:1396-402. 2011
    ..Limited animal, in vitro, and human studies have reported that exposure to phthalates or bisphenol A (BPA) may affect thyroid signaling...
  22. pmc Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan
    Wei Chun Chou
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    Environ Health 10:94. 2011
    ....
  23. pmc Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring
    Paloma Alonso-Magdalena
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Universidad Miguel Hernandez de Elche, Elche, Spain
    Environ Health Perspect 118:1243-50. 2010
    ..In humans, epidemiological evidence has associated BPA exposure in adults with higher risk of type 2 diabetes and heart disease...
  24. pmc Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities
    Patrick Allard
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:20405-10. 2010
    ..C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis...
  25. pmc Estrogen and xenoestrogens in breast cancer
    S V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Toxicol Pathol 38:110-22. 2010
    ..These studies provide firsthand evidence that the natural estrogen 17beta-estradiol and xenoestrogenic substances like bisphenol A are able to induce neoplastic transformation in human breast epithelial cells...
  26. ncbi Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1
    Hiromasa Ooe
    Graduate School of Pharmaceutical Sciences, Graduate School of Agriculture, Hokkaido University, Sapporo 060 0812, Japan
    Toxicol Sci 88:114-26. 2005
    ..DJ-1 was found to maintain the complex I activity against BPA-induced oxidative stress after the localization in mitochondria. The results showed that DJ-1 plays a role in the prevention of mitochondrial injury-induced cell death...
  27. ncbi Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats
    R W Tyl
    RTI, Research Triangle Park, North Carolina 27709 2194, USA
    Toxicol Sci 68:121-46. 2002
    ..001-5 mg/kg/day) on any parameters and no evidence of nonmonotonic dose-response curves across generations for either sex. BPA should not be considered a selective reproductive toxicant, based on the results of this study...
  28. ncbi Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: a cross-sectional analysis
    Guang Ning
    Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Ann Intern Med 155:368-74. 2011
    ..Greater bisphenol A exposure has been shown to be associated with a higher risk for self-reported adverse health outcomes, including diabetes...
  29. pmc Variability and predictors of urinary bisphenol A concentrations during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard University, Boston, Massachusetts, USA
    Environ Health Perspect 119:131-7. 2011
    ..Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy...
  30. pmc Components of plastic: experimental studies in animals and relevance for human health
    Chris E Talsness
    Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Charité University Medical School Berlin, Berlin, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2079-96. 2009
    ....
  31. ncbi Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption
    Peter Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    J Steroid Biochem Mol Biol 102:175-9. 2006
    ..The results indicate that nontraditional estrogen actions mediated through GPR30 are potentially susceptible to disruption by a variety of environmental estrogens...
  32. pmc Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β
    Sergi Soriano
    Instituto Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Universidad Miguel Hernandez de Elche, Elche, Alicante, Spain
    PLoS ONE 7:e31109. 2012
    ..This supports that BPA should be considered as a risk factor for metabolic disorders in humans...
  33. ncbi Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure
    Justin G Teeguarden
    Fundamental and Computational Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Toxicol Sci 123:48-57. 2011
    ..During these high dietary exposures, (TOT)BPA concentrations in serum were undetectable in 83% of the 320 samples collected and BPA concentrations were determined to be less than or equal to LOD in all samples...
  34. ncbi Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
    R Grempler
    CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
    Diabetes Obes Metab 14:83-90. 2012
    ..This study assessed pharmacological properties of empagliflozin in vitro and pharmacokinetic properties in vivo and compared its potency and selectivity with other SGLT-2 inhibitors...
  35. pmc Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S Observatory St, Ann Arbor, MI 48109, USA
    Reprod Toxicol 30:532-9. 2010
    ..03%, 19%) increase in sperm DNA damage measured as the percentage of DNA in comet tail. In conclusion, urinary BPA may be associated with declined semen quality and increased sperm DNA damage, but confirmatory studies are needed...
  36. pmc Pancreatic insulin content regulation by the estrogen receptor ER alpha
    Paloma Alonso-Magdalena
    Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, Alicante, Spain
    PLoS ONE 3:e2069. 2008
    ..The up-regulation of pancreatic insulin content by ER alpha activation involves ERK1/2. These data may be important to explain the actions of E2 and environmental estrogens in endocrine pancreatic function and blood glucose homeostasis...
  37. ncbi Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance
    Tiange Wang
    Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Clin Endocrinol Metab 97:E223-7. 2012
    ..Bisphenol A (BPA) is one of the world's highest-volume chemicals in use today. Previous studies have suggested BPA disturbs body weight regulation and promotes obesity and insulin resistance. But epidemiological data in humans were limited...
  38. ncbi Transfer of bisphenol A from thermal printer paper to the skin
    Sandra Biedermann
    Official Food Control Authority of the Canton of Zurich, P O Box 1471, CH 8032, Zurich, Switzerland
    Anal Bioanal Chem 398:571-6. 2010
    ..However, if more than just the finger pads contact the BPA-containing paper or a hand cream enhances permeability of the skin, this margin might be smaller...
  39. pmc Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention
    Ruthann A Rudel
    Silent Spring Institute, Newton, Massachusetts 02458, USA
    Environ Health Perspect 119:914-20. 2011
    ..They have been associated with endocrine disruption in animals and in some human studies. Human exposure sources have been estimated, but the relative contribution of dietary exposure to total intake has not been studied empirically...
  40. pmc Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06
    David Melzer
    Epidemiology and Public Health Group, Peninsula Medical School, University of Exeter, Exeter, United Kingdom
    PLoS ONE 5:e8673. 2010
    ..We aimed to estimate associations between urinary BPA concentrations and health measures in NHANES 2005/06 and in data pooled across collection years...
  41. pmc Human body burdens of chemicals used in plastic manufacture
    Holger M Koch
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Bochum, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2063-78. 2009
    ..We discuss several factors relevant for interpreting and understanding biomonitoring data, including selection of both biomarkers of exposure and human matrices, and toxicokinetic information...
  42. pmc Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway
    Jackye Peretz
    Department of Comparative Biosciences, University of Illinois, Urbana, Illinois 61802, USA
    Toxicol Sci 119:209-17. 2011
    ..Collectively, these data show that BPA targets the estradiol biosynthesis pathway in the ovary...
  43. pmc Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome
    Nira Ben-Jonathan
    Department of Cancer and Cell Biology, University of Cincinnati, OH 45267, USA
    Mol Cell Endocrinol 304:49-54. 2009
    ..The implications of these observations to the obesity-related metabolic syndrome and its sequelae are discussed...
  44. ncbi Relationship between urine bisphenol-A level and declining male sexual function
    De Kun Li
    Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
    J Androl 31:500-6. 2010
    ..This finding may enhance the understanding of the BPA effect in human populations, and may have important public health implications given the widespread human exposure to BPA...
  45. pmc Case report: high prenatal bisphenol a exposure and infant neonatal neurobehavior
    Sheela Sathyanarayana
    Department of Pediatrics, University of Washington, Seattle, Washington 98145 5005, USA
    Environ Health Perspect 119:1170-5. 2011
    ..Most of the U.S. population is exposed to the high-production-volume chemical bisphenol A (BPA), but targetable sources of exposure remain to be determined. Animal studies and one human study suggest that BPA is a neurotoxicant...
  46. pmc Bisphenol A alters the development of the rhesus monkey mammary gland
    Andrew P Tharp
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 109:8190-5. 2012
    ..No significant differences were observed in ER expression. Altogether, gestational exposure to the estrogen-mimic BPA altered the developing mammary glands of female nonhuman primates in a comparable manner to that observed in rodents...
  47. ncbi In utero exposure to bisphenol-A and its effect on birth weight of offspring
    Maohua Miao
    Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, CA 94612, United States
    Reprod Toxicol 32:64-8. 2011
    ..003). Our findings provide the new epidemiologic evidence suggesting that in utero exposure to BPA during pregnancy may be associated with decreased birth weight in offspring...
  48. ncbi Effect of environmental contaminants on Beta cell function
    Emilija Makaji
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Int J Toxicol 30:410-8. 2011
    ..These data suggest that long-term BPA exposure may be detrimental to beta cell function and ultimately be an important contributor to the etiology of T2D...
  49. pmc Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats
    Gail S Prins
    Department of Urology, 820 S Wood St, MC 955, University of Illinois at Chicago, Chicago, IL 60612, USA
    Reprod Toxicol 31:1-9. 2011
    ..These findings on prostate health are directly relevant to humans at current BPA exposure levels...
  50. pmc Prenatal bisphenol A exposure and early childhood behavior
    Joe M Braun
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 117:1945-52. 2009
    ..Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents...
  51. ncbi Urine bisphenol-A (BPA) level in relation to semen quality
    De Kun Li
    Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, California, USA
    Fertil Steril 95:625-30.e1-4. 2011
    ..To determine whether urine bisphenol-A (BPA) levels are associated with lower semen quality...
  52. pmc Urinary bisphenol A and type-2 diabetes in U.S. adults: data from NHANES 2003-2008
    Monica K Silver
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e26868. 2011
    ..We used a different diagnosis method of T2DM (hemoglobin A1c (HbA1c)) with a larger subset of NHANES...
  53. ncbi Modafinil: a review of neurochemical actions and effects on cognition
    Michael J Minzenberg
    Imaging Research Center, Davis School of Medicine, UC Davis Health System, University of California, Sacramento, CA 95817, USA
    Neuropsychopharmacology 33:1477-502. 2008
    ..These effects are in general advantageous for cognitive processes. Overall, modafinil is an excellent candidate agent for remediation of cognitive dysfunction in neuropsychiatric disorders...
  54. ncbi Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 146:607-12. 2005
    ....
  55. pmc Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:391-5. 2005
    ..S. population) and relatively small size, this study provides the first reference range of human internal dose levels of BPA and NP in a demographically diverse human population...
  56. ncbi Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels
    Yonghua He
    School of Public Health WHO Collaborating Center for Occupational Health, Fudan University, Box 288, No 130, Dong an Road, Shanghai 200032, PR China
    Environ Res 109:629-33. 2009
    ..The results indicated that half of the study subjects had detectable BPA in their urine samples. BPA levels were influenced by gender and smoking status. The sources of non-occupational BPA exposures should be explored...
  57. ncbi Bisphenol A induces reactive oxygen species generation in the liver of male rats
    V Bindhumol
    School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
    Toxicology 188:117-24. 2003
    ..The results indicated that bisphenol A induces oxidative stress in the liver of rats by decreasing the antioxidant enzymes. Co-administration of vitamin C reversed the effects of bisphenol A-induced oxidative stress in the liver of rats...
  58. ncbi The pancreatic beta-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes
    Angel Nadal
    Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Universidad Miguel Hernandez de Elche, Alicante, Spain
    Mol Cell Endocrinol 304:63-8. 2009
    ..This may provoke insulin resistance in the liver and muscle, as well as beta-cell exhaustion and therefore, it may contribute to the development of type II diabetes...
  59. ncbi Urinary bisphenol A concentrations and their implications for human exposure in several Asian countries
    Zifeng Zhang
    International Joint Research Center for Persistent Toxic Substances, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China
    Environ Sci Technol 45:7044-50. 2011
    ..S. Environmental Protection Agency. This is the first study to document the occurrence of and human exposure to BPA in several Asian countries...
  60. ncbi Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A-treated rats and formation of DNA adducts in cultured human prostatic cells
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Toxicol Sci 122:45-51. 2011
    ..On the whole, these experimental findings support mechanistically the hypothesis that BPA may play a role in prostate carcinogenesis and may, potentially, affect the quality of sperm...
  61. ncbi Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol A
    Leping Ye
    The 2nd Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    Toxicol Lett 207:137-42. 2011
    ..In conclusion, BPA is an inhibitor for 3β-HSD, CYP17A1 and 17β-HSD3. Human 3β-HSD and CYP17A1 are more sensitive to BPA than rat 3β-HSD and CYP17A1...
  62. pmc Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice
    Karen K Ryan
    Department of Internal Medicine, Division of Endocrinology, The University of Cincinnati College of Medicine, 2170 East Galbraith Road, Mail Location 0503, Cincinnati, Ohio 45237, USA
    Endocrinology 151:2603-12. 2010
    ..We conclude that this larger size-for-age represents a faster rate of growth early in development rather than an obese, diabetic phenotype in adulthood...
  63. pmc Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes
    Eric R Hugo
    Department of Cell and Cancer Biology, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Environ Health Perspect 116:1642-7. 2008
    ..Thus, any factor that suppresses adiponectin release could lead to insulin resistance and increased susceptibility to obesity-associated diseases...
  64. ncbi Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathways
    Paloma Alonso-Magdalena
    Instituto de Bioingeniería and CIBERDEM, Universidad Miguel Hernandez de Elche, 03202 Elche, Spain
    Mol Cell Endocrinol 355:201-7. 2012
    ..Thus, the purpose of the present review is to analyze with substantiated scientific evidence the strong estrogenic activity of BPA when it acts through alternative mechanisms of action at least in certain cell types...
  65. pmc Relationship between urinary bisphenol A levels and diabetes mellitus
    Anoop Shankar
    Department of Community Medicine, West Virginia University School of Medicine, P O Box 9190, Morgantown, West Virginia 26506 9190, USA
    J Clin Endocrinol Metab 96:3822-6. 2011
    ..However, few human studies have examined the association between markers of BPA exposure and diabetes mellitus...
  66. ncbi Viable skin efficiently absorbs and metabolizes bisphenol A
    Daniel Zalko
    INRA, UMR1089 Xenobiotiques, 180 chemin de Tournefeuille, BP 93173, 31027 Toulouse Cedex 3, France
    Chemosphere 82:424-30. 2011
    ..The trans-dermal route is expected to contribute substantially to BPA exposure in human, when direct contact with BPA (free monomer) occurs...
  67. pmc Gene expression in the fetal mouse ovary is altered by exposure to low doses of bisphenol A
    Crystal Lawson
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164 7520, USA
    Biol Reprod 84:79-86. 2011
    ..Furthermore, gene ontology analysis suggested that BPA acts to down-regulate mitotic cell-cycle genes, raising the possibility that fetal BPA exposure may act to limit expansion of the primordial germ cell population...
  68. pmc The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Mol Cell Endocrinol 354:74-84. 2012
    ....
  69. pmc The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropharmacology 54:542-51. 2008
    ..In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release...
  70. ncbi Neonatal exposure to bisphenol A reduces the pool of primordial follicles in the rat ovary
    Horacio A Rodríguez
    Laboratorio de Endocrinologia y Tumores Hormonodependientes, Ciudad Universitaria, Paraje El Pozo, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, CP 3000 Santa Fe, Argentina
    Reprod Toxicol 30:550-7. 2010
    ..Results show that BPA reduces the primordial follicle pool by stimulating the neonatal initial recruitment, associated with an increased proliferation rate likely mediated by an estrogenic pathway...
  71. pmc Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 119:63-70. 2011
    ..Comparison of E2 uterine transcript profiles and those of other estrogenic chemicals of interest in vivo indicates mechanisms and activities of test compounds...
  72. pmc Estrogenic environmental chemicals and drugs: mechanisms for effects on the developing male urogenital system
    Julia A Taylor
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    J Steroid Biochem Mol Biol 127:83-95. 2011
    ..The findings presented here provide additional evidence that BPA and the estrogenic drug ethinylestradiol disrupt prostate development in male mice at administered doses relevant to human exposures...
  73. ncbi Widespread occurrence of bisphenol A in paper and paper products: implications for human exposure
    ChunYang Liao
    Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, United States
    Environ Sci Technol 45:9372-9. 2011
    ..Among paper products, thermal receipt papers contributed to the majority (>98%) of the exposures...
  74. ncbi Modafinil for excessive sleepiness associated with shift-work sleep disorder
    Charles A Czeisler
    Division of Sleep Medicine, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 353:476-86. 2005
    ..Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder...
  75. pmc Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor
    Adil Bouskine
    Institut National de la recherché Médicale INSERM U895, Team 5 Environment and Reproduction Genomic and Nongenomic Mechanisms, University of Nice Sophia Antipolis, Faculty of Medicine, Nice, France
    Environ Health Perspect 117:1053-8. 2009
    ..Thus, several mechanisms have been suggested to explain how they could affect male germ cell proliferation at low environmental relevant concentrations...
  76. pmc Maternal bisphenol a exposure promotes the development of experimental asthma in mouse pups
    Terumi Midoro-Horiuti
    Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, Galveston, TX 77555 0366, USA
    Environ Health Perspect 118:273-7. 2010
    ..We recently reported that various environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators in vitro...
  77. pmc Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    JAMA 301:1148-54. 2009
    ..Although initially launched as distinct from stimulants that increase extracellular dopamine by targeting dopamine transporters, recent preclinical studies suggest otherwise...
  78. pmc Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A
    J G Hengstler
    Leibniz Research Centre for Working Environment and Human Factors IfADo, University of Dortmund, Dortmund, Germany
    Crit Rev Toxicol 41:263-91. 2011
    ....
  79. pmc Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Ave, Boston, MA 02111, United States
    Reprod Toxicol 26:210-9. 2008
    ..Similar structures have also been observed following exposure to other estrogens. These results are further evidence that perinatal BPA exposure can alter the morphology of the rodent mammary gland in adulthood...
  80. ncbi Bisphenol a exposure causes meiotic aneuploidy in the female mouse
    Patricia A Hunt
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
    Curr Biol 13:546-53. 2003
    ....
  81. pmc Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activation
    Robert M Sargis
    Department of Medicine, Institute of Endocrine Discovery and Clinical Care, The University of Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:1283-8. 2010
    ..Thus, EDCs are able to promote adipogenesis through the activation of the GR, further implicating these compounds in the rising rates of obesity and diabetes...
  82. pmc The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006
    Erin M Rees Clayton
    Department of Epidemiology, Center for Social Epidemiology and Population Health, University of Michigan School of Public Health, Ann Arbor, 48109 2029, USA
    Environ Health Perspect 119:390-6. 2011
    ..Exposure to environmental toxicants is associated with numerous disease outcomes, many of which involve underlying immune and inflammatory dysfunction...
  83. ncbi Bisphenol A disrupts steroidogenesis in human H295R cells
    Xiaowei Zhang
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China
    Toxicol Sci 121:320-7. 2011
    ..These results suggest that BPA has the potential to interfere with cellular steroidogenesis in humans through multiple molecular mechanisms...
  84. ncbi Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism
    Xian Yang Qin
    Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Japan
    Toxicol Lett 206:152-7. 2011
    ..In conclusion, we have shown for the first time that ARNT2 expression is modulated by xenoestrogens by an ESR1-dependent mechanism in MCF-7 breast cancer cells...
  85. ncbi Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior
    Keiko Nakamura
    Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
    Brain Dev 34:57-63. 2012
    ..These results indicated that prenatal and lactational BPA exposure disturbed the murine behavior in the postnatal development period and the adult mice...
  86. pmc The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors
    Kyle C Schmitt
    Department of Pharmacology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e25790. 2011
    ..Our findings highlight a mechanistic difference between modafinil and cocaine-like stimulants and further demonstrate that the conformational effects of a given DAT inhibitor influence its phenomenological effects...
  87. pmc Prenatal bisphenol a exposure and child behavior in an inner-city cohort
    Frederica Perera
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 120:1190-4. 2012
    ..However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior...
  88. ncbi Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRI
    Michael J Minzenberg
    Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA
    Science 322:1700-2. 2008
    ..These results confirm in humans the role of the LC-NE system in PFC function and cognitive control and suggest a mechanism for therapeutic action of procognitive noradrenergic agents...
  89. pmc Modafinil for the treatment of cocaine dependence
    Ann L Anderson
    Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892 9551, USA
    Drug Alcohol Depend 104:133-9. 2009
    ..Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo...
  90. ncbi Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies
    David V Herin
    Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA
    Ann N Y Acad Sci 1187:76-100. 2010
    ..This report reviews preclinical, human laboratory, and clinical trial data supporting the agonist-like approach, including risks and benefits. Future directions for development of agonist-like medications are also discussed...
  91. pmc Randomized, double-blind, placebo-controlled trial of modafinil for the treatment of methamphetamine dependence
    Keith G Heinzerling
    Department of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Drug Alcohol Depend 109:20-9. 2010
    ..To compare modafinil to placebo for reducing methamphetamine (MA) use, improving retention, and reducing depressive symptoms and MA cravings. Rates of adverse events and cigarette smoking with modafinil versus placebo were also compared...
  92. ncbi Modafinil treatment for fatigue associated with fibromyalgia
    Thomas L Schwartz
    Department of Psychiatry, SUNY Upstate Medical Univeristy, Syracuse, New York 13210, USA
    J Clin Rheumatol 13:52. 2007
  93. ncbi The principles of agonist pharmacotherapy for psychostimulant dependence
    James Shearer
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia
    Drug Alcohol Rev 27:301-8. 2008
    ..No medications to date have been any more successful than placebo in reducing psychostimulant use in dependent patients. Agonist strategies have attracted limited attention...
  94. pmc Evaluation of modafinil effects on cardiovascular, subjective, and reinforcing effects of methamphetamine in methamphetamine-dependent volunteers
    Richard De La Garza
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Drug Alcohol Depend 106:173-80. 2010
    ..Given these encouraging, though non-significant trends, the primary conclusion is that it appears safe to proceed with modafinil in further clinical evaluations of therapeutic efficacy...
  95. ncbi Recovery from chronic fatigue syndrome with modafinil
    Douglas Turkington
    Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Hum Psychopharmacol 19:63-4. 2004
  96. ncbi Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndrome
    Delia C Randall
    Psychopharmacology Research Unit, Centre for Neuroscience Research, King s College London, London, UK
    J Psychopharmacol 19:647-60. 2005
    ..It is discussed whether the limited and mixed cognitive effects that we observed could have occurred by chance, or whether a subgroup of CFS patients with daytime sleepiness would have shown greater benefits...
  97. ncbi Biotransformation of bisphenol F by human and rat liver subcellular fractions
    Nicolas Cabaton
    ENSBANA, UMR 1229 FLAVIC, F 21000 Dijon, France
    Toxicol In Vitro 22:1697-704. 2008
    ..Both the formation of a catechol and of dimeric metabolites correspond to biotransformation pathways shared by BPF, other bisphenols and estradiol...
  98. ncbi A double-blind, placebo-controlled trial of modafinil (200 mg/day) for methamphetamine dependence
    James Shearer
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia
    Addiction 104:224-33. 2009
    ..To examine the safety and efficacy of modafinil (200 mg/day) compared to placebo in the treatment of methamphetamine dependence and to examine predictors of post-treatment outcome...
  99. ncbi Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 319:561-9. 2006
    ..The present data provide compelling evidence that modafinil occupies the DAT and NET in living brain of rhesus monkeys and raise the possibility that modafinil affects wakefulness by interacting with catecholamine transporters in brain...
  100. ncbi Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson's disease
    Charles H Adler
    Parkinson s Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic Scottsdale, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
    Mov Disord 18:287-93. 2003
    ..Our data demonstrate that, in a small sample size, administration of 200 mg/day of modafinil was associated with few side effects and was modestly effective for the treatment of excessive daytime sleepiness in patients with PD...
  101. ncbi Urinary incontinence at orgasm: relation to detrusor overactivity and treatment efficacy
    Maurizio Serati
    Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Piazza Biroldi 1, Varese, Italy
    Eur Urol 54:911-5. 2008
    ..To understand the pathophysiological mechanism of incontinence during orgasm and to compare women affected by symptomatic detrusor overactivity (DO) with and without incontinence at orgasm in terms of efficacy of antimuscarinic treatment...

Research Grants67

  1. Urodynamic and Multiethnic Variability of Men Treated b*
    Steven Kaplan; Fiscal Year: 2005
    ..Baseline urodynamic parameters which may predict improved outcome after MIST 3. The success of various types of MIST in treating BPH in African - American, Hispanic and Caucasian men. ..
  2. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2003
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  3. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2008
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  4. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2004
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  5. Prenatal NSAID Use and Miscarriage
    De Kun Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  6. Exposure to Bisphenol A & Reproductive Effect in Humans
    De Kun Li; Fiscal Year: 2007
    ..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
  7. Prenatal MF Exposure & Miscarriage Risk Among Women
    De Kun Li; Fiscal Year: 2009
    ..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
  8. INDUCED ABORTION AND BREAST CANCER RISK
    De Kun Li; Fiscal Year: 2001
    ....
  9. Controlled Study of SAMe vs.Escitalopram in Major Depressive Disorder
    Maurizio Fava; Fiscal Year: 2008
    ..Secondary aims are to assess the acute effects of SAMe or escitalopram vs. placebo on remission rates, quality of life, and psychosocial functioning. ..
  10. BUPROPION AS AN ADJUNCT TO THE NICOTINE PATCH PLUS CBT
    Maurizio Fava; Fiscal Year: 2003
    ....
  11. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  12. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  13. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  14. Does perinatal exposure to Bisphenol A contribute to adult obesity
    BEVERLY RUBIN; Fiscal Year: 2007
    ..It is expected that these results, in turn, may generate a better understanding of the obesity problem, and provide elements to help devise a sound policy addressing this serious public health problem. ..
  15. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  16. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2006
    ..5a-reductase activity will be determined by radiometric assay. ..
  17. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  18. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  19. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  20. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  21. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2001
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
  22. THE USE OF ELECTROACUPUNCTURE TO MODULATE AROUSAL
    Edgar Garcia Rill; Fiscal Year: 2002
    ..However, the optimal stimulation sites and paradigms muse be identified and proven effective, first, in control populations, and later, in pathological populations. ..
  23. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  24. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  25. LONGITUDINAL FOLLOW UP OF ADHD GIRLS AND THEIR SIBLINGS
    Joseph Biederman; Fiscal Year: 2002
    ....
  26. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  27. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  29. AGE-RELATED LOSS OF CYCLICITY--LHRH NEURONAL DYSFUNCTION
    BEVERLY RUBIN; Fiscal Year: 2002
    ..The studies proposed will determine if modulation of excitatory and inhibitory neurotransmission can enhance the normally diminished levels of LHRH neuronal activity in middle-aged females. ..
  30. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  31. Pelvic Floor Changes Before and After Birth
    REBECCA GLENN ROGERS; Fiscal Year: 2010
    ..This project will provide fundamental data to guide future decisions about labor interventions to prevent PF changes as well as data-based decisions regarding maternal request cesarean. ..
  32. Minimally Invasive Surgical Therapies Treatment Consort*
    Claus Roehrborn; Fiscal Year: 2005
    ..The MIST Study Group will be a blueprint for a technology assessment group applicable to other areas of urology and other medical or surgical subspecialties. ..
  33. Iowa Pelvic Floor Disorders Clinical Trials Network
    Karl Kreder; Fiscal Year: 2005
    ..abstract_text> ..
  34. TREATMENT OF SLEEP APNEA IN THE ELDERLY
    Allan Pack; Fiscal Year: 2003
    ..These data will give novel definitive information both about identification and treatment of sleep apnea in the elderly. ..
  35. Negative Effects of Bisphenol A on the Monkey CNS
    Csaba Leranth; Fiscal Year: 2008
    ..Therefore, we propose to reveal the effect of BPA on estrogen-induced spine synapse formation in the brain of non-human primates, which will provide more relevance to human health. [unreadable] [unreadable] [unreadable]..
  36. NEONATAL EFFECTS AND METABOLISM OF XENOESTROGENS
    Nira Ben Jonathan; Fiscal Year: 2003
    ..The results should provide a much needed experimental foundation for assessing the vulnerability of the neuroendocrine system to insults by environmental factors. ..
  37. Preventing Cocaine Relapse: Developing Pharmacotherapies
    CRAIG RUSH; Fiscal Year: 2008
    ..Reducing relapse to drug use is important because intravenous abuse of cocaine may be associated with increased risk of acquired immunodeficiency syndrome (A.I.D.S.). ..
  38. Drug Effects on Behavior: Workplace Implications
    Carl Hart; Fiscal Year: 2008
    ..Together, the data from the proposed studies will have substantial public health impact and will serve both educational and public policy functions. ..
  39. Prolactin and Estrogens as Mitogens in Prostate Cancer
    Nira Ben Jonathan; Fiscal Year: 2002
    ..The findings on BPA may reveal the potential risk associated with human exposure to environmental estrogens. ..
  40. NEUROENDOCRINE CONTROL OF FSH
    Vasantha Padmanabhan; Fiscal Year: 2001
    ....
  41. Reproductive Consequences of Prenatal Androgenization
    Vasantha Padmanabhan; Fiscal Year: 2005
    ..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..
  42. Stimulant Abuse Pharmacotherapy: Novel Antipsychotics
    CRAIG RUSH; Fiscal Year: 2009
    ..The proposed research will provide initial scientific and clinical information regarding the use of aripiprazole as a pharmacotherapy for the treatment of methamphetamine dependence, and guide the design of future clinical trials. ..
  43. Bisphenol-A and the Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2008
    ..The findings will be relevant to research on fetal origin of infertility and the threat estrogenic environmental disruptors at current exposure levels pose to human health. ..
  44. Intranasal Methamphetamine: A Pharmacotherapy Model
    Carl Hart; Fiscal Year: 2009
    ....
  45. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  46. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  47. Development Estrogenization of the Rat Prostate Gland
    Gail S Prins; Fiscal Year: 2010
    ..Results will further define the mechanisms of estrogen's actions on the prostate gland during early development and lead to a better understanding of the hormonal and developmental basis for abnormal prostate growth with aging...
  48. GABA Agonists as Pharmacotherapies for Cocaine Abuse
    CRAIG RUSH; Fiscal Year: 2003
    ..Finally, the proposed research will allow us to conduct retrospective analyses to determine the influence of individual differences (e.g., gender, other drug use) on the reinforcing and subjective effects of cocaine. ..
  49. MICROARRAY EXPRESSION PROFILING OF RODENT MODELS OF HUMA
    Allan Pack; Fiscal Year: 2003
    ..abstract_text> ..
  50. Xenoestrogens: Genomic and Non-genomic Mechanisms
    Nira Ben Jonathan; Fiscal Year: 2006
    ..The results of these studies should provide much needed experimental foundation for assessing the vulnerability of the pituitary gland to insults by endocrine disruptors. ..
  51. Subcortical Estrogen Effect on The Hippocampus
    Csaba Leranth; Fiscal Year: 2005
    ..cholinergic and GABAergic septo-hippocampal neurons involved in mediating estrogenic effect to the hippocampus? and (d) Do SUM neurons mediate estrogenic effect to the hippocampus directly or indirectly, via the MSDB? ..
  52. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  53. ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATON
    Gail Prins; Fiscal Year: 2005
    ....
  54. Aripiprazole for Clozapine Associated Medical Morbidity
    David Henderson; Fiscal Year: 2007
    ..Clinical adjunctive therapy may establish aripiprazole as a new therapeutic approach in schizophrenia and clozapine-associated medical disorders. ..
  55. Estrogenic Effect on Hippocampal Theta Rhythm and Memory
    Csaba Leranth; Fiscal Year: 2004
    ....
  56. Family Linkage Study of Obstructive Sleep Apnea
    Allan Pack; Fiscal Year: 2007
    ..abstract_text> ..
  57. Interstitial Cystitis Clinical Research Network (ICCRN)
    Karl Kreder; Fiscal Year: 2007
    ..abstract_text> ..
  58. ASSESSING ABUSE POTENTIAL IN HUMAN--CNS STIMULANTS
    CRAIG RUSH; Fiscal Year: 2004
    ..abstract_text> ..
  59. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ....
  60. Agonist Replacement Therapy for Cocaine Dependence: Identifying Novel Medications
    CRAIG RUSH; Fiscal Year: 2009
    ..Identifying novel agonist replacement therapies is important because clinicians may be reluctant to use d-amphetamine because of its abuse potential. ..
  61. Regulation of Bladder Smooth Muscle Hyperplasia
    Paul Austin; Fiscal Year: 2007
    ..Work of this nature may decrease the morbidity and mortality that is caused by bladder outlet obstruction. ..
  62. Sensory Testing in Subjects with Interstitial Cystitis
    Mary FitzGerald; Fiscal Year: 2004
    ..abstract_text> ..
  63. ECG-derived estimators of sleep physiology
    Robert Thomas; Fiscal Year: 2006
    ..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
  64. MONOAMINERGIC REGULATION OF GABA AND SCHIZOPHRENIA
    ARIEL DEUTCH; Fiscal Year: 2004
    ..Moreover, a large literature suggest that NT may have atypical antipsychotic drug like properties, the proposed studies address current hypotheses of schizophrenia and may increase our knowledge of the pathophysiology of schizophrenia. ..
  65. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..