Genomes and Genes
Summary: Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.
Publications273 found, 100 shown here
- Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004Antonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Environ Health Perspect 116:39-44. 2008..Bisphenol A (BPA) and 4-tertiary-octylphenol (tOP) are industrial chemicals used in the manufacture of polycarbonate plastics and epoxy resins (BPA) and nonionic surfactants (tOP). These products are in widespread use in the United States...
- Association between urinary bisphenol A concentration and obesity prevalence in children and adolescentsLeonardo Trasande
Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA
JAMA 308:1113-21. 2012..In adults, elevated urinary BPA concentrations are associated with obesity and incident coronary artery disease. BPA exposure is plausibly linked to childhood obesity, but evidence is lacking to date...
- Human exposure to bisphenol A (BPA)Laura N Vandenberg
Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
Reprod Toxicol 24:139-77. 2007..The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models...
- Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol ALaura N Vandenberg
Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
Environ Health Perspect 118:1055-70. 2010..Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. Importantly, results from a large number of biomonitoring studies are at odds with the results from two toxicokinetic studies...
- Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adultsIain A Lang
Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
JAMA 300:1303-10. 2008..Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans...
- Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 miceNicolas J Cabaton
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Environ Health Perspect 119:547-52. 2011..Perinatal exposure to low-doses of bisphenol A (BPA) results in alterations in the ovary, uterus, and mammary glands and in a sexually dimorphic region of the brain known to be important for estrous cyclicity...
- Bisphenol A: an endocrine disruptor with widespread exposure and multiple effectsBeverly S Rubin
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
J Steroid Biochem Mol Biol 127:27-34. 2011..Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging...
- Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruptionLaura N Vandenberg
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
Endocr Rev 30:75-95. 2009....
- Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancyJoe M Braun
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 120:739-45. 2012..Gestational phthalate and bisphenol A (BPA) exposure may increase the risk of adverse maternal/child health outcomes, but there are few data on the variability of urinary biomarkers before and during pregnancy...
- Urinary bisphenol A and obesity: NHANES 2003-2006Jenny L Carwile
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
Environ Res 111:825-30. 2011..We hypothesized that urinary BPA concentrations would be positively associated with general and central obesity...
- Impact of early-life bisphenol A exposure on behavior and executive function in childrenJoe M Braun
Department of Environmental Health, Harvard School of Public Health, Harvard University, Boston, MA 02130, USA
Pediatrics 128:873-82. 2011..To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations...
- Temporal variability and predictors of urinary bisphenol A concentrations in men and womenShruthi Mahalingaiah
Department of Obstetrics and Gynecology, Brigham and Women s Hospital, 665 Huntington Avenue, Boston, MA 02115, USA
Environ Health Perspect 116:173-8. 2008..Bisphenol A (BPA) is used to manufacture polymeric materials, such as polycarbonate plastics, and is found in a variety of consumer products. Recent data show widespread BPA exposure among the U.S. population...
- Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male miceThiago M Batista
Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, Sao Paulo, Brazil
PLoS ONE 7:e33814. 2012..Thus, our findings support the notion that BPA can be considered a risk factor for the development of type 2 diabetes...
- Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: relevance for human exposureJulia A Taylor
Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Environ Health Perspect 119:422-30. 2011..We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration of BPA and compared findings in mice and monkeys with prior published data in women...
- Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat dietJie Wei
Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Endocrinology 152:3049-61. 2011..High-fat diet intake is a trigger that initiates adverse metabolic effects of BPA...
- Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collectionsXiaoyun Ye
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 119:983-8. 2011..Therefore, there is considerable within-person and between-person variability of BPA concentrations in spot urine samples. However, no information exists on the within-day variability of urinary BPA concentrations...
- Bisphenol A: Perinatal exposure and body weightBeverly S Rubin
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
Mol Cell Endocrinol 304:55-62. 2009..The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed...
- Perinatal exposure to bisphenol a alters early adipogenesis in the ratEmmanuel Somm
Faculty of Medicine, University of Geneva, Geneva, Switzerland
Environ Health Perspect 117:1549-55. 2009..The causes of the current obesity pandemic have not been fully elucidated. Implication of environmental endocrine disruptors such as bisphenol A (BPA) on adipose tissue development has been poorly investigated...
- Comparison of serum bisphenol A concentrations in mice exposed to bisphenol A through the diet versus oral bolus exposurePaizlee T Sieli
Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
Environ Health Perspect 119:1260-5. 2011..Bisphenol A (BPA) is a widely produced endocrine-disrupting chemical. Diet is a primary route of exposure, but internal exposure (serum concentrations) in animals and humans has been measured only after single oral bolus administration...
- Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen responseJason G Bromer
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
FASEB J 24:2273-80. 2010..Permanent epigenetic alteration of ERE sensitivity to estrogen may be a general mechanism through which endocrine disruptors exert their action...
- Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008John D Meeker
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Environ Health Perspect 119:1396-402. 2011..Limited animal, in vitro, and human studies have reported that exposure to phthalates or bisphenol A (BPA) may affect thyroid signaling...
- Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in TaiwanWei Chun Chou
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
Environ Health 10:94. 2011....
- Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspringPaloma Alonso-Magdalena
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Universidad Miguel Hernandez de Elche, Elche, Spain
Environ Health Perspect 118:1243-50. 2010..In humans, epidemiological evidence has associated BPA exposure in adults with higher risk of type 2 diabetes and heart disease...
- Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalitiesPatrick Allard
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:20405-10. 2010..C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis...
- Estrogen and xenoestrogens in breast cancerS V Fernandez
Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Toxicol Pathol 38:110-22. 2010..These studies provide firsthand evidence that the natural estrogen 17beta-estradiol and xenoestrogenic substances like bisphenol A are able to induce neoplastic transformation in human breast epithelial cells...
- Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1Hiromasa Ooe
Graduate School of Pharmaceutical Sciences, Graduate School of Agriculture, Hokkaido University, Sapporo 060 0812, Japan
Toxicol Sci 88:114-26. 2005..DJ-1 was found to maintain the complex I activity against BPA-induced oxidative stress after the localization in mitochondria. The results showed that DJ-1 plays a role in the prevention of mitochondrial injury-induced cell death...
- Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley ratsR W Tyl
RTI, Research Triangle Park, North Carolina 27709 2194, USA
Toxicol Sci 68:121-46. 2002..001-5 mg/kg/day) on any parameters and no evidence of nonmonotonic dose-response curves across generations for either sex. BPA should not be considered a selective reproductive toxicant, based on the results of this study...
- Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: a cross-sectional analysisGuang Ning
Shanghai Jiao Tong University School of Medicine, Shanghai, China
Ann Intern Med 155:368-74. 2011..Greater bisphenol A exposure has been shown to be associated with a higher risk for self-reported adverse health outcomes, including diabetes...
- Variability and predictors of urinary bisphenol A concentrations during pregnancyJoe M Braun
Department of Environmental Health, Harvard University, Boston, Massachusetts, USA
Environ Health Perspect 119:131-7. 2011..Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy...
- Components of plastic: experimental studies in animals and relevance for human healthChris E Talsness
Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Charité University Medical School Berlin, Berlin, Germany
Philos Trans R Soc Lond B Biol Sci 364:2079-96. 2009....
- Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruptionPeter Thomas
Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
J Steroid Biochem Mol Biol 102:175-9. 2006..The results indicate that nontraditional estrogen actions mediated through GPR30 are potentially susceptible to disruption by a variety of environmental estrogens...
- Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor βSergi Soriano
Instituto Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Universidad Miguel Hernandez de Elche, Elche, Alicante, Spain
PLoS ONE 7:e31109. 2012..This supports that BPA should be considered as a risk factor for metabolic disorders in humans...
- Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposureJustin G Teeguarden
Fundamental and Computational Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Toxicol Sci 123:48-57. 2011..During these high dietary exposures, (TOT)BPA concentrations in serum were undetectable in 83% of the 320 samples collected and BPA concentrations were determined to be less than or equal to LOD in all samples...
- Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitorsR Grempler
CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
Diabetes Obes Metab 14:83-90. 2012..This study assessed pharmacological properties of empagliflozin in vitro and pharmacokinetic properties in vivo and compared its potency and selectivity with other SGLT-2 inhibitors...
- Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinicJohn D Meeker
Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S Observatory St, Ann Arbor, MI 48109, USA
Reprod Toxicol 30:532-9. 2010..03%, 19%) increase in sperm DNA damage measured as the percentage of DNA in comet tail. In conclusion, urinary BPA may be associated with declined semen quality and increased sperm DNA damage, but confirmatory studies are needed...
- Pancreatic insulin content regulation by the estrogen receptor ER alphaPaloma Alonso-Magdalena
Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, Alicante, Spain
PLoS ONE 3:e2069. 2008..The up-regulation of pancreatic insulin content by ER alpha activation involves ERK1/2. These data may be important to explain the actions of E2 and environmental estrogens in endocrine pancreatic function and blood glucose homeostasis...
- Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistanceTiange Wang
Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
J Clin Endocrinol Metab 97:E223-7. 2012..Bisphenol A (BPA) is one of the world's highest-volume chemicals in use today. Previous studies have suggested BPA disturbs body weight regulation and promotes obesity and insulin resistance. But epidemiological data in humans were limited...
- Transfer of bisphenol A from thermal printer paper to the skinSandra Biedermann
Official Food Control Authority of the Canton of Zurich, P O Box 1471, CH 8032, Zurich, Switzerland
Anal Bioanal Chem 398:571-6. 2010..However, if more than just the finger pads contact the BPA-containing paper or a hand cream enhances permeability of the skin, this margin might be smaller...
- Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary interventionRuthann A Rudel
Silent Spring Institute, Newton, Massachusetts 02458, USA
Environ Health Perspect 119:914-20. 2011..They have been associated with endocrine disruption in animals and in some human studies. Human exposure sources have been estimated, but the relative contribution of dietary exposure to total intake has not been studied empirically...
- Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06David Melzer
Epidemiology and Public Health Group, Peninsula Medical School, University of Exeter, Exeter, United Kingdom
PLoS ONE 5:e8673. 2010..We aimed to estimate associations between urinary BPA concentrations and health measures in NHANES 2005/06 and in data pooled across collection years...
- Human body burdens of chemicals used in plastic manufactureHolger M Koch
BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Bochum, Germany
Philos Trans R Soc Lond B Biol Sci 364:2063-78. 2009..We discuss several factors relevant for interpreting and understanding biomonitoring data, including selection of both biomarkers of exposure and human matrices, and toxicokinetic information...
- Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathwayJackye Peretz
Department of Comparative Biosciences, University of Illinois, Urbana, Illinois 61802, USA
Toxicol Sci 119:209-17. 2011..Collectively, these data show that BPA targets the estradiol biosynthesis pathway in the ovary...
- Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndromeNira Ben-Jonathan
Department of Cancer and Cell Biology, University of Cincinnati, OH 45267, USA
Mol Cell Endocrinol 304:49-54. 2009..The implications of these observations to the obesity-related metabolic syndrome and its sequelae are discussed...
- Relationship between urine bisphenol-A level and declining male sexual functionDe Kun Li
Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
J Androl 31:500-6. 2010..This finding may enhance the understanding of the BPA effect in human populations, and may have important public health implications given the widespread human exposure to BPA...
- Case report: high prenatal bisphenol a exposure and infant neonatal neurobehaviorSheela Sathyanarayana
Department of Pediatrics, University of Washington, Seattle, Washington 98145 5005, USA
Environ Health Perspect 119:1170-5. 2011..Most of the U.S. population is exposed to the high-production-volume chemical bisphenol A (BPA), but targetable sources of exposure remain to be determined. Animal studies and one human study suggest that BPA is a neurotoxicant...
- Bisphenol A alters the development of the rhesus monkey mammary glandAndrew P Tharp
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 109:8190-5. 2012..No significant differences were observed in ER expression. Altogether, gestational exposure to the estrogen-mimic BPA altered the developing mammary glands of female nonhuman primates in a comparable manner to that observed in rodents...
- In utero exposure to bisphenol-A and its effect on birth weight of offspringMaohua Miao
Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, CA 94612, United States
Reprod Toxicol 32:64-8. 2011..003). Our findings provide the new epidemiologic evidence suggesting that in utero exposure to BPA during pregnancy may be associated with decreased birth weight in offspring...
- Effect of environmental contaminants on Beta cell functionEmilija Makaji
Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
Int J Toxicol 30:410-8. 2011..These data suggest that long-term BPA exposure may be detrimental to beta cell function and ultimately be an important contributor to the etiology of T2D...
- Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley ratsGail S Prins
Department of Urology, 820 S Wood St, MC 955, University of Illinois at Chicago, Chicago, IL 60612, USA
Reprod Toxicol 31:1-9. 2011..These findings on prostate health are directly relevant to humans at current BPA exposure levels...
- Prenatal bisphenol A exposure and early childhood behaviorJoe M Braun
Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
Environ Health Perspect 117:1945-52. 2009..Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents...
- Urine bisphenol-A (BPA) level in relation to semen qualityDe Kun Li
Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, California, USA
Fertil Steril 95:625-30.e1-4. 2011..To determine whether urine bisphenol-A (BPA) levels are associated with lower semen quality...
- Urinary bisphenol A and type-2 diabetes in U.S. adults: data from NHANES 2003-2008Monica K Silver
Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 6:e26868. 2011..We used a different diagnosis method of T2DM (hemoglobin A1c (HbA1c)) with a larger subset of NHANES...
- Modafinil: a review of neurochemical actions and effects on cognitionMichael J Minzenberg
Imaging Research Center, Davis School of Medicine, UC Davis Health System, University of California, Sacramento, CA 95817, USA
Neuropsychopharmacology 33:1477-502. 2008..These effects are in general advantageous for cognitive processes. Overall, modafinil is an excellent candidate agent for remediation of cognitive dysfunction in neuropsychiatric disorders...
- Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brainR Thomas Zoeller
Biology Department, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
Endocrinology 146:607-12. 2005....
- Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference populationAntonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 113:391-5. 2005..S. population) and relatively small size, this study provides the first reference range of human internal dose levels of BPA and NP in a demographically diverse human population...
- Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levelsYonghua He
School of Public Health WHO Collaborating Center for Occupational Health, Fudan University, Box 288, No 130, Dong an Road, Shanghai 200032, PR China
Environ Res 109:629-33. 2009..The results indicated that half of the study subjects had detectable BPA in their urine samples. BPA levels were influenced by gender and smoking status. The sources of non-occupational BPA exposures should be explored...
- Bisphenol A induces reactive oxygen species generation in the liver of male ratsV Bindhumol
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Toxicology 188:117-24. 2003..The results indicated that bisphenol A induces oxidative stress in the liver of rats by decreasing the antioxidant enzymes. Co-administration of vitamin C reversed the effects of bisphenol A-induced oxidative stress in the liver of rats...
- The pancreatic beta-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetesAngel Nadal
Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Universidad Miguel Hernandez de Elche, Alicante, Spain
Mol Cell Endocrinol 304:63-8. 2009..This may provoke insulin resistance in the liver and muscle, as well as beta-cell exhaustion and therefore, it may contribute to the development of type II diabetes...
- Urinary bisphenol A concentrations and their implications for human exposure in several Asian countriesZifeng Zhang
International Joint Research Center for Persistent Toxic Substances, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China
Environ Sci Technol 45:7044-50. 2011..S. Environmental Protection Agency. This is the first study to document the occurrence of and human exposure to BPA in several Asian countries...
- Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A-treated rats and formation of DNA adducts in cultured human prostatic cellsSilvio De Flora
Department of Health Sciences, University of Genoa, Genoa, Italy
Toxicol Sci 122:45-51. 2011..On the whole, these experimental findings support mechanistically the hypothesis that BPA may play a role in prostate carcinogenesis and may, potentially, affect the quality of sperm...
- Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol ALeping Ye
The 2nd Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
Toxicol Lett 207:137-42. 2011..In conclusion, BPA is an inhibitor for 3β-HSD, CYP17A1 and 17β-HSD3. Human 3β-HSD and CYP17A1 are more sensitive to BPA than rat 3β-HSD and CYP17A1...
- Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 miceKaren K Ryan
Department of Internal Medicine, Division of Endocrinology, The University of Cincinnati College of Medicine, 2170 East Galbraith Road, Mail Location 0503, Cincinnati, Ohio 45237, USA
Endocrinology 151:2603-12. 2010..We conclude that this larger size-for-age represents a faster rate of growth early in development rather than an obese, diabetic phenotype in adulthood...
- Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytesEric R Hugo
Department of Cell and Cancer Biology, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267, USA
Environ Health Perspect 116:1642-7. 2008..Thus, any factor that suppresses adiponectin release could lead to insulin resistance and increased susceptibility to obesity-associated diseases...
- Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathwaysPaloma Alonso-Magdalena
Instituto de Bioingeniería and CIBERDEM, Universidad Miguel Hernandez de Elche, 03202 Elche, Spain
Mol Cell Endocrinol 355:201-7. 2012..Thus, the purpose of the present review is to analyze with substantiated scientific evidence the strong estrogenic activity of BPA when it acts through alternative mechanisms of action at least in certain cell types...
- Relationship between urinary bisphenol A levels and diabetes mellitusAnoop Shankar
Department of Community Medicine, West Virginia University School of Medicine, P O Box 9190, Morgantown, West Virginia 26506 9190, USA
J Clin Endocrinol Metab 96:3822-6. 2011..However, few human studies have examined the association between markers of BPA exposure and diabetes mellitus...
- Viable skin efficiently absorbs and metabolizes bisphenol ADaniel Zalko
INRA, UMR1089 Xenobiotiques, 180 chemin de Tournefeuille, BP 93173, 31027 Toulouse Cedex 3, France
Chemosphere 82:424-30. 2011..The trans-dermal route is expected to contribute substantially to BPA exposure in human, when direct contact with BPA (free monomer) occurs...
- Gene expression in the fetal mouse ovary is altered by exposure to low doses of bisphenol ACrystal Lawson
School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164 7520, USA
Biol Reprod 84:79-86. 2011..Furthermore, gene ontology analysis suggested that BPA acts to down-regulate mitotic cell-cycle genes, raising the possibility that fetal BPA exposure may act to limit expansion of the primordial germ cell population...
- The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesityFrederick S vom Saal
Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
Mol Cell Endocrinol 354:74-84. 2012....
- The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in ratsXia Li
Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
Neuropharmacology 54:542-51. 2008..In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release...
- Neonatal exposure to bisphenol A reduces the pool of primordial follicles in the rat ovaryHoracio A Rodríguez
Laboratorio de Endocrinologia y Tumores Hormonodependientes, Ciudad Universitaria, Paraje El Pozo, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, CP 3000 Santa Fe, Argentina
Reprod Toxicol 30:550-7. 2010..Results show that BPA reduces the primordial follicle pool by stimulating the neonatal initial recruitment, associated with an increased proliferation rate likely mediated by an estrogenic pathway...
- Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profilesSylvia C Hewitt
Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 119:63-70. 2011..Comparison of E2 uterine transcript profiles and those of other estrogenic chemicals of interest in vivo indicates mechanisms and activities of test compounds...
- Estrogenic environmental chemicals and drugs: mechanisms for effects on the developing male urogenital systemJulia A Taylor
Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
J Steroid Biochem Mol Biol 127:83-95. 2011..The findings presented here provide additional evidence that BPA and the estrogenic drug ethinylestradiol disrupt prostate development in male mice at administered doses relevant to human exposures...
- Widespread occurrence of bisphenol A in paper and paper products: implications for human exposureChunYang Liao
Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, United States
Environ Sci Technol 45:9372-9. 2011..Among paper products, thermal receipt papers contributed to the majority (>98%) of the exposures...
- Modafinil for excessive sleepiness associated with shift-work sleep disorderCharles A Czeisler
Division of Sleep Medicine, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 353:476-86. 2005..Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder...
- Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptorAdil Bouskine
Institut National de la recherché Médicale INSERM U895, Team 5 Environment and Reproduction Genomic and Nongenomic Mechanisms, University of Nice Sophia Antipolis, Faculty of Medicine, Nice, France
Environ Health Perspect 117:1053-8. 2009..Thus, several mechanisms have been suggested to explain how they could affect male germ cell proliferation at low environmental relevant concentrations...
- Maternal bisphenol a exposure promotes the development of experimental asthma in mouse pupsTerumi Midoro-Horiuti
Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, Galveston, TX 77555 0366, USA
Environ Health Perspect 118:273-7. 2010..We recently reported that various environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators in vitro...
- Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implicationsNora D Volkow
National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
JAMA 301:1148-54. 2009..Although initially launched as distinct from stimulants that increase extracellular dopamine by targeting dopamine transporters, recent preclinical studies suggest otherwise...
- Critical evaluation of key evidence on the human health hazards of exposure to bisphenol AJ G Hengstler
Leibniz Research Centre for Working Environment and Human Factors IfADo, University of Dortmund, Dortmund, Germany
Crit Rev Toxicol 41:263-91. 2011....
- Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 miceLaura N Vandenberg
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Ave, Boston, MA 02111, United States
Reprod Toxicol 26:210-9. 2008..Similar structures have also been observed following exposure to other estrogens. These results are further evidence that perinatal BPA exposure can alter the morphology of the rodent mammary gland in adulthood...
- Bisphenol a exposure causes meiotic aneuploidy in the female mousePatricia A Hunt
Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
Curr Biol 13:546-53. 2003....
- Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activationRobert M Sargis
Department of Medicine, Institute of Endocrine Discovery and Clinical Care, The University of Chicago, Chicago, Illinois, USA
Obesity (Silver Spring) 18:1283-8. 2010..Thus, EDCs are able to promote adipogenesis through the activation of the GR, further implicating these compounds in the rising rates of obesity and diabetes...
- The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006Erin M Rees Clayton
Department of Epidemiology, Center for Social Epidemiology and Population Health, University of Michigan School of Public Health, Ann Arbor, 48109 2029, USA
Environ Health Perspect 119:390-6. 2011..Exposure to environmental toxicants is associated with numerous disease outcomes, many of which involve underlying immune and inflammatory dysfunction...
- Bisphenol A disrupts steroidogenesis in human H295R cellsXiaowei Zhang
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China
Toxicol Sci 121:320-7. 2011..These results suggest that BPA has the potential to interfere with cellular steroidogenesis in humans through multiple molecular mechanisms...
- Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanismXian Yang Qin
Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Japan
Toxicol Lett 206:152-7. 2011..In conclusion, we have shown for the first time that ARNT2 expression is modulated by xenoestrogens by an ESR1-dependent mechanism in MCF-7 breast cancer cells...
- Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behaviorKeiko Nakamura
Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
Brain Dev 34:57-63. 2012..These results indicated that prenatal and lactational BPA exposure disturbed the murine behavior in the postnatal development period and the adult mice...
- The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsKyle C Schmitt
Department of Pharmacology, New York University School of Medicine, New York, New York, United States of America
PLoS ONE 6:e25790. 2011..Our findings highlight a mechanistic difference between modafinil and cocaine-like stimulants and further demonstrate that the conformational effects of a given DAT inhibitor influence its phenomenological effects...
- Prenatal bisphenol a exposure and child behavior in an inner-city cohortFrederica Perera
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 120:1190-4. 2012..However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior...
- Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRIMichael J Minzenberg
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA
Science 322:1700-2. 2008..These results confirm in humans the role of the LC-NE system in PFC function and cognitive control and suggest a mechanism for therapeutic action of procognitive noradrenergic agents...
- Modafinil for the treatment of cocaine dependenceAnn L Anderson
Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892 9551, USA
Drug Alcohol Depend 104:133-9. 2009..Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo...
- Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studiesDavid V Herin
Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA
Ann N Y Acad Sci 1187:76-100. 2010..This report reviews preclinical, human laboratory, and clinical trial data supporting the agonist-like approach, including risks and benefits. Future directions for development of agonist-like medications are also discussed...
- Randomized, double-blind, placebo-controlled trial of modafinil for the treatment of methamphetamine dependenceKeith G Heinzerling
Department of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Drug Alcohol Depend 109:20-9. 2010..To compare modafinil to placebo for reducing methamphetamine (MA) use, improving retention, and reducing depressive symptoms and MA cravings. Rates of adverse events and cigarette smoking with modafinil versus placebo were also compared...
- Modafinil treatment for fatigue associated with fibromyalgiaThomas L Schwartz
Department of Psychiatry, SUNY Upstate Medical Univeristy, Syracuse, New York 13210, USA
J Clin Rheumatol 13:52. 2007
- The principles of agonist pharmacotherapy for psychostimulant dependenceJames Shearer
National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia
Drug Alcohol Rev 27:301-8. 2008..No medications to date have been any more successful than placebo in reducing psychostimulant use in dependent patients. Agonist strategies have attracted limited attention...
- Evaluation of modafinil effects on cardiovascular, subjective, and reinforcing effects of methamphetamine in methamphetamine-dependent volunteersRichard De La Garza
Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Drug Alcohol Depend 106:173-80. 2010..Given these encouraging, though non-significant trends, the primary conclusion is that it appears safe to proceed with modafinil in further clinical evaluations of therapeutic efficacy...
- Recovery from chronic fatigue syndrome with modafinilDouglas Turkington
Royal Victoria Infirmary, Newcastle upon Tyne, UK
Hum Psychopharmacol 19:63-4. 2004
- Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndromeDelia C Randall
Psychopharmacology Research Unit, Centre for Neuroscience Research, King s College London, London, UK
J Psychopharmacol 19:647-60. 2005..It is discussed whether the limited and mixed cognitive effects that we observed could have occurred by chance, or whether a subgroup of CFS patients with daytime sleepiness would have shown greater benefits...
- Biotransformation of bisphenol F by human and rat liver subcellular fractionsNicolas Cabaton
ENSBANA, UMR 1229 FLAVIC, F 21000 Dijon, France
Toxicol In Vitro 22:1697-704. 2008..Both the formation of a catechol and of dimeric metabolites correspond to biotransformation pathways shared by BPF, other bisphenols and estradiol...
- A double-blind, placebo-controlled trial of modafinil (200 mg/day) for methamphetamine dependenceJames Shearer
National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia
Addiction 104:224-33. 2009..To examine the safety and efficacy of modafinil (200 mg/day) compared to placebo in the treatment of methamphetamine dependence and to examine predictors of post-treatment outcome...
- Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitroBertha K Madras
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
J Pharmacol Exp Ther 319:561-9. 2006..The present data provide compelling evidence that modafinil occupies the DAT and NET in living brain of rhesus monkeys and raise the possibility that modafinil affects wakefulness by interacting with catecholamine transporters in brain...
- Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson's diseaseCharles H Adler
Parkinson s Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic Scottsdale, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
Mov Disord 18:287-93. 2003..Our data demonstrate that, in a small sample size, administration of 200 mg/day of modafinil was associated with few side effects and was modestly effective for the treatment of excessive daytime sleepiness in patients with PD...
- Urinary incontinence at orgasm: relation to detrusor overactivity and treatment efficacyMaurizio Serati
Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Piazza Biroldi 1, Varese, Italy
Eur Urol 54:911-5. 2008..To understand the pathophysiological mechanism of incontinence during orgasm and to compare women affected by symptomatic detrusor overactivity (DO) with and without incontinence at orgasm in terms of efficacy of antimuscarinic treatment...
- Urodynamic and Multiethnic Variability of Men Treated b*Steven Kaplan; Fiscal Year: 2005..Baseline urodynamic parameters which may predict improved outcome after MIST 3. The success of various types of MIST in treating BPH in African - American, Hispanic and Caucasian men. ..
- DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTSJudith Rabkin; Fiscal Year: 2003..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
- Modafinil Treatment for Fatigue in HIV+ PatientsJudith Rabkin; Fiscal Year: 2008..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
- DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMESJudith Rabkin; Fiscal Year: 2004..The data collected in the preliminary study will be used in the full-scale study. ..
- Prenatal NSAID Use and MiscarriageDe Kun Li; Fiscal Year: 2008..unreadable] [unreadable]..
- Exposure to Bisphenol A & Reproductive Effect in HumansDe Kun Li; Fiscal Year: 2007..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
- Prenatal MF Exposure & Miscarriage Risk Among WomenDe Kun Li; Fiscal Year: 2009..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
- INDUCED ABORTION AND BREAST CANCER RISKDe Kun Li; Fiscal Year: 2001....
- Controlled Study of SAMe vs.Escitalopram in Major Depressive DisorderMaurizio Fava; Fiscal Year: 2008..Secondary aims are to assess the acute effects of SAMe or escitalopram vs. placebo on remission rates, quality of life, and psychosocial functioning. ..
- BUPROPION AS AN ADJUNCT TO THE NICOTINE PATCH PLUS CBTMaurizio Fava; Fiscal Year: 2003....
- DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKSThomas Roth; Fiscal Year: 2003..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
- Collaborative Pediatric Bipolar Disorder ConferenceJoseph Biederman; Fiscal Year: 2007..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- Does perinatal exposure to Bisphenol A contribute to adult obesityBEVERLY RUBIN; Fiscal Year: 2007..It is expected that these results, in turn, may generate a better understanding of the obesity problem, and provide elements to help devise a sound policy addressing this serious public health problem. ..
- Adult Outcome of Attention Deficit Hyperactivity DisorderJoseph Biederman; Fiscal Year: 2007..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
- Developmental toxicity of environmental chemicalsFREDERICK VOM SAAL; Fiscal Year: 2006..5a-reductase activity will be determined by radiometric assay. ..
- Epidemiology and Mechanisms of Fecal IncontinenceAdil Bharucha; Fiscal Year: 2005..abstract_text> ..
- Coactivation of Estrogen Receptor alpha/Sp1Stephen Safe; Fiscal Year: 2006..abstract_text> ..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTHJoseph Biederman; Fiscal Year: 2001..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
- THE USE OF ELECTROACUPUNCTURE TO MODULATE AROUSALEdgar Garcia Rill; Fiscal Year: 2002..However, the optimal stimulation sites and paradigms muse be identified and proven effective, first, in control populations, and later, in pathological populations. ..
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2009..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDERAdil Bharucha; Fiscal Year: 2002..abstract_text> ..
- LONGITUDINAL FOLLOW UP OF ADHD GIRLS AND THEIR SIBLINGSJoseph Biederman; Fiscal Year: 2002....
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- Course of psychopathology in female youth: Analysis with extant longitudinal dataJoseph Biederman; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- AGE-RELATED LOSS OF CYCLICITY--LHRH NEURONAL DYSFUNCTIONBEVERLY RUBIN; Fiscal Year: 2002..The studies proposed will determine if modulation of excitatory and inhibitory neurotransmission can enhance the normally diminished levels of LHRH neuronal activity in middle-aged females. ..
- Inhibition of Pancreatic Cancer by New PPARgamma Agonis*Stephen Safe; Fiscal Year: 2008..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
- Pelvic Floor Changes Before and After BirthREBECCA GLENN ROGERS; Fiscal Year: 2010..This project will provide fundamental data to guide future decisions about labor interventions to prevent PF changes as well as data-based decisions regarding maternal request cesarean. ..
- Minimally Invasive Surgical Therapies Treatment Consort*Claus Roehrborn; Fiscal Year: 2005..The MIST Study Group will be a blueprint for a technology assessment group applicable to other areas of urology and other medical or surgical subspecialties. ..
- Iowa Pelvic Floor Disorders Clinical Trials NetworkKarl Kreder; Fiscal Year: 2005..abstract_text> ..
- TREATMENT OF SLEEP APNEA IN THE ELDERLYAllan Pack; Fiscal Year: 2003..These data will give novel definitive information both about identification and treatment of sleep apnea in the elderly. ..
- Negative Effects of Bisphenol A on the Monkey CNSCsaba Leranth; Fiscal Year: 2008..Therefore, we propose to reveal the effect of BPA on estrogen-induced spine synapse formation in the brain of non-human primates, which will provide more relevance to human health. [unreadable] [unreadable] [unreadable]..
- NEONATAL EFFECTS AND METABOLISM OF XENOESTROGENSNira Ben Jonathan; Fiscal Year: 2003..The results should provide a much needed experimental foundation for assessing the vulnerability of the neuroendocrine system to insults by environmental factors. ..
- Preventing Cocaine Relapse: Developing PharmacotherapiesCRAIG RUSH; Fiscal Year: 2008..Reducing relapse to drug use is important because intravenous abuse of cocaine may be associated with increased risk of acquired immunodeficiency syndrome (A.I.D.S.). ..
- Drug Effects on Behavior: Workplace ImplicationsCarl Hart; Fiscal Year: 2008..Together, the data from the proposed studies will have substantial public health impact and will serve both educational and public policy functions. ..
- Prolactin and Estrogens as Mitogens in Prostate CancerNira Ben Jonathan; Fiscal Year: 2002..The findings on BPA may reveal the potential risk associated with human exposure to environmental estrogens. ..
- NEUROENDOCRINE CONTROL OF FSHVasantha Padmanabhan; Fiscal Year: 2001....
- Reproductive Consequences of Prenatal AndrogenizationVasantha Padmanabhan; Fiscal Year: 2005..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..
- Stimulant Abuse Pharmacotherapy: Novel AntipsychoticsCRAIG RUSH; Fiscal Year: 2009..The proposed research will provide initial scientific and clinical information regarding the use of aripiprazole as a pharmacotherapy for the treatment of methamphetamine dependence, and guide the design of future clinical trials. ..
- Bisphenol-A and the Reproductive DysfunctionVasantha Padmanabhan; Fiscal Year: 2008..The findings will be relevant to research on fetal origin of infertility and the threat estrogenic environmental disruptors at current exposure levels pose to human health. ..
- Intranasal Methamphetamine: A Pharmacotherapy ModelCarl Hart; Fiscal Year: 2009....
- GABA Medications for Tobacco AddictionMehmet Sofuoglu; Fiscal Year: 2009..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
- Cocaine Withdrawal and Pharmacotherapy ResponseMehmet Sofuoglu; Fiscal Year: 2010..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
- Development Estrogenization of the Rat Prostate GlandGail S Prins; Fiscal Year: 2010..Results will further define the mechanisms of estrogen's actions on the prostate gland during early development and lead to a better understanding of the hormonal and developmental basis for abnormal prostate growth with aging...
- GABA Agonists as Pharmacotherapies for Cocaine AbuseCRAIG RUSH; Fiscal Year: 2003..Finally, the proposed research will allow us to conduct retrospective analyses to determine the influence of individual differences (e.g., gender, other drug use) on the reinforcing and subjective effects of cocaine. ..
- MICROARRAY EXPRESSION PROFILING OF RODENT MODELS OF HUMAAllan Pack; Fiscal Year: 2003..abstract_text> ..
- Xenoestrogens: Genomic and Non-genomic MechanismsNira Ben Jonathan; Fiscal Year: 2006..The results of these studies should provide much needed experimental foundation for assessing the vulnerability of the pituitary gland to insults by endocrine disruptors. ..
- Subcortical Estrogen Effect on The HippocampusCsaba Leranth; Fiscal Year: 2005..cholinergic and GABAergic septo-hippocampal neurons involved in mediating estrogenic effect to the hippocampus? and (d) Do SUM neurons mediate estrogenic effect to the hippocampus directly or indirectly, via the MSDB? ..
- Progestrone and the Effects of NicotineMehmet Sofuoglu; Fiscal Year: 2006..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
- ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATONGail Prins; Fiscal Year: 2005....
- Aripiprazole for Clozapine Associated Medical MorbidityDavid Henderson; Fiscal Year: 2007..Clinical adjunctive therapy may establish aripiprazole as a new therapeutic approach in schizophrenia and clozapine-associated medical disorders. ..
- Estrogenic Effect on Hippocampal Theta Rhythm and MemoryCsaba Leranth; Fiscal Year: 2004....
- Family Linkage Study of Obstructive Sleep ApneaAllan Pack; Fiscal Year: 2007..abstract_text> ..
- Interstitial Cystitis Clinical Research Network (ICCRN)Karl Kreder; Fiscal Year: 2007..abstract_text> ..
- ASSESSING ABUSE POTENTIAL IN HUMAN--CNS STIMULANTSCRAIG RUSH; Fiscal Year: 2004..abstract_text> ..
- Endocrine Disruptors and Fetal DevelopmentVasantha Padmanabhan; Fiscal Year: 2010....
- Agonist Replacement Therapy for Cocaine Dependence: Identifying Novel MedicationsCRAIG RUSH; Fiscal Year: 2009..Identifying novel agonist replacement therapies is important because clinicians may be reluctant to use d-amphetamine because of its abuse potential. ..
- Regulation of Bladder Smooth Muscle HyperplasiaPaul Austin; Fiscal Year: 2007..Work of this nature may decrease the morbidity and mortality that is caused by bladder outlet obstruction. ..
- Sensory Testing in Subjects with Interstitial CystitisMary FitzGerald; Fiscal Year: 2004..abstract_text> ..
- ECG-derived estimators of sleep physiologyRobert Thomas; Fiscal Year: 2006..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
- MONOAMINERGIC REGULATION OF GABA AND SCHIZOPHRENIAARIEL DEUTCH; Fiscal Year: 2004..Moreover, a large literature suggest that NT may have atypical antipsychotic drug like properties, the proposed studies address current hypotheses of schizophrenia and may increase our knowledge of the pathophysiology of schizophrenia. ..
- MOLECULAR NEUROBIOLOGY OF DEPRESSIONRichard Shelton; Fiscal Year: 2003..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..