calcium dobesilate

Summary

Summary: A drug used to reduce hemorrhage in diabetic retinopathy.

Top Publications

  1. ncbi Calcium dobesilate: pharmacology and future approaches
    T Tejerina
    Department of Pharmacology, School of Medicine, Complutense University, Madrid, Spain
    Gen Pharmacol 31:357-60. 1998
  2. ncbi Pharmacological agents in the treatment of venous disease: an update of the available evidence
    Manjit S Gohel
    Imperial Vascular Unit, Charing Cross Hospital, Fulham Palace Road, London, UK
    Curr Vasc Pharmacol 7:303-8. 2009
  3. ncbi Flow injection chemiluninescence for detecting picogram amounts of dobesilate in human urine
    Zhenghua Song
    Department of Chemistry, Northwest University, Taibai Road 229, Xi an 710069, China
    Spectrochim Acta A Mol Biomol Spectrosc 60:2377-82. 2004
  4. ncbi Enhancement of both EDHF and NO/cGMP pathways is necessary to reverse erectile dysfunction in diabetic rats
    Javier Angulo
    Instituto de Medicina Sexual, Fundación para la Investigación y el Desarollo en Andrología, Madrid, Spain
    J Sex Med 2:341-6. 2005
  5. ncbi Effect of calcium dobesilate on progression of early diabetic retinopathy: a randomised double-blind study
    Maria L Ribeiro
    AIBILI, Clinical Trial Centre, Azinhaga de Santa Comba, 3000 548 Coimbra, Portugal
    Graefes Arch Clin Exp Ophthalmol 244:1591-600. 2006
  6. pmc Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes
    Ermelindo C Leal
    Center of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Diabetes 59:2637-45. 2010
  7. ncbi Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids
    Herve Allain
    Service de Pharmacologie, Faculte de Medecine, Universite de Rennes 1, Rennes, France
    Drug Saf 27:649-60. 2004
  8. ncbi Therapeutic response of rosacea to dobesilate
    Pedro Cuevas
    Department of Research, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Med Res 10:454-6. 2005
  9. ncbi Doxium (calcium dobesilate) reduces blood hyperviscosity and lowers elevated intraocular pressure in patients with diabetic retinopathy and glaucoma
    B Vojnikovic
    Ophthalmic Clinic, University Hospital, Rijeka, Yugoslavia
    Ophthalmic Res 23:12-20. 1991
  10. ncbi Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial proliferation, arterial relaxation, vascular permeability and angiogenesis by dobesilate
    Javier Angulo
    Servicio de Histologia, Departamento de Investigacion, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Eur J Pharmacol 667:153-9. 2011

Scientific Experts

Detail Information

Publications82

  1. ncbi Calcium dobesilate: pharmacology and future approaches
    T Tejerina
    Department of Pharmacology, School of Medicine, Complutense University, Madrid, Spain
    Gen Pharmacol 31:357-60. 1998
    1. Calcium dobesilate (2,5-dihydroxybenzene sulfonate) is a drug commonly used in the treatment of diabetic retinopathy and chronic venous insufficiency. 2...
  2. ncbi Pharmacological agents in the treatment of venous disease: an update of the available evidence
    Manjit S Gohel
    Imperial Vascular Unit, Charing Cross Hospital, Fulham Palace Road, London, UK
    Curr Vasc Pharmacol 7:303-8. 2009
    ..Oxerutins and calcium dobesilate may be of benefit in reducing oedema and rutosides may help to relieve the symptoms of varicose veins in ..
  3. ncbi Flow injection chemiluninescence for detecting picogram amounts of dobesilate in human urine
    Zhenghua Song
    Department of Chemistry, Northwest University, Taibai Road 229, Xi an 710069, China
    Spectrochim Acta A Mol Biomol Spectrosc 60:2377-82. 2004
    ..It was also found that the dobesilate concentration reached its maximum after orally administrated for 3.5h, and the excretion ratio in 24h was 58.8% in the body of volunteers...
  4. ncbi Enhancement of both EDHF and NO/cGMP pathways is necessary to reverse erectile dysfunction in diabetic rats
    Javier Angulo
    Instituto de Medicina Sexual, Fundación para la Investigación y el Desarollo en Andrología, Madrid, Spain
    J Sex Med 2:341-6. 2005
    ..have evaluated the effects of sildenafil, a PDE5 inhibitor that enhances the nitric oxide (NO)/cGMP pathway, calcium dobesilate (DOBE), which potentiates endothelium-derived hyperpolarizing factor (EDHF)-mediated responses and the ..
  5. ncbi Effect of calcium dobesilate on progression of early diabetic retinopathy: a randomised double-blind study
    Maria L Ribeiro
    AIBILI, Clinical Trial Centre, Azinhaga de Santa Comba, 3000 548 Coimbra, Portugal
    Graefes Arch Clin Exp Ophthalmol 244:1591-600. 2006
    The study was carried out to confirm the effect of calcium dobesilate (CaD) compared to placebo (PLA) on the blood-retinal barrier (BRB) permeability in early diabetic retinopathy (DR).
  6. pmc Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes
    Ermelindo C Leal
    Center of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Diabetes 59:2637-45. 2010
    b>Calcium dobesilate (CaD) has been used in the treatment of diabetic retinopathy in the last decades, but its mechanisms of action are not elucidated...
  7. ncbi Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids
    Herve Allain
    Service de Pharmacologie, Faculte de Medecine, Universite de Rennes 1, Rennes, France
    Drug Saf 27:649-60. 2004
    The aim of the present review is to consider the adverse effects and the safety profile of calcium dobesilate. Calcium dobesilate (Doxium) is a veno-tonic drug, which is widely prescribed in more than 60 countries from Europe, Latin ..
  8. ncbi Therapeutic response of rosacea to dobesilate
    Pedro Cuevas
    Department of Research, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Med Res 10:454-6. 2005
    ..Thus, dobesilate might be useful in the treatment of rosacea and other diseases that depend on pathologic angiogenesis...
  9. ncbi Doxium (calcium dobesilate) reduces blood hyperviscosity and lowers elevated intraocular pressure in patients with diabetic retinopathy and glaucoma
    B Vojnikovic
    Ophthalmic Clinic, University Hospital, Rijeka, Yugoslavia
    Ophthalmic Res 23:12-20. 1991
    ..with early retinopathy and open-angle glaucoma received orally either three 500-mg capsules of Doxium (calcium dobesilate) daily for 6 months (41 patients) or three placebo capsules daily for the same period (38 patients)...
  10. ncbi Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial proliferation, arterial relaxation, vascular permeability and angiogenesis by dobesilate
    Javier Angulo
    Servicio de Histologia, Departamento de Investigacion, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Eur J Pharmacol 667:153-9. 2011
    ..As a dual antagonist of VEGF and FGF activities, DHBS could be of therapeutic interest in the treatment of diseases related to VEGF/FGF overproduction and excessive angiogenesis...
  11. ncbi Antioxidant properties of calcium dobesilate in ischemic/reperfused diabetic rat retina
    M E Szabo
    Department of Ophthalmology, School of Medicine, University of Debrecen, Debrecen, Hungary
    Eur J Pharmacol 428:277-86. 2001
    b>Calcium dobesilate possesses antioxidant properties and protects against capillary permeability by reactive oxygen species in the rat peritoneal cavity, but whether a similar action can take place in the diabetic rat retina is unknown...
  12. ncbi Dobesilate is an angiogenesis inhibitor
    Pedro Cuevas
    Servicio de Histologia, Departamento de Investigacion, Hospital Ramon y Cajal, Ctra de Colmenar, Km 9 100, E 28034 Madrid, Spain
    Eur J Med Res 10:369-72. 2005
    ..These findings suggest that dobesilate could be an effective agent in the treatment of angiogenesis-dependent diseases involving FGFs...
  13. ncbi Inhibition of choroidal angiogenesis by calcium dobesilate in normal Wistar and diabetic GK rats
    Stéphane Lameynardie
    Laboratoire de Nutrition Humaine et Athérogenèse, Institut Universitaire de Recherche Clinique, Montpellier, France
    Eur J Pharmacol 510:149-56. 2005
    b>Calcium dobesilate reduces vascular endothelial growth factor (VEGF) over-expression in diabetic rat retina, but its effect on intraocular angiogenesis is unknown...
  14. ncbi Calcium dobesilate and oxerutin: effectiveness of combination therapy
    B Akbulut
    Department of Cardiovascular Surgery, Kutahya State Hospital, Kutahya, Turkey
    Phlebology 25:66-71. 2010
    ..b>Calcium dobesilate is a synthetic venoactive drug acting on several levels...
  15. pmc Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries
    Javier Angulo
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Spain
    Br J Pharmacol 139:854-62. 2003
    ..In addition, the effect of the angioprotective agent, calcium dobesilate (DOBE), on the endothelium-dependent relaxation of these tissues was investigated...
  16. ncbi Calcium dobesilate in patients suffering from chronic venous insufficiency: a double-blind, placebo-controlled, clinical trial
    E Rabe
    Department of Dermatology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Phlebology 26:162-8. 2011
    To test the efficacy of calcium dobesilate (CaD) in chronic venous insufficiency (CVI).
  17. ncbi Calcium dobesilate in the treatment of diabetic retinopathy
    Ricardo P Garay
    Equipe d Accueil EA2381, Laboratoire Pharmacologie Transports Ioniques Membranaires, Universite Paris 7, Paris, France
    Treat Endocrinol 4:221-32. 2005
    ..In contrast, calcium dobesilate (2,5-dihydroxybenzenesulfonate), which was discovered more than 40 years ago and is registered for the ..
  18. ncbi Calcium dobesilate attenuates vascular injury and the progression of diabetic retinopathy in streptozotocin-induced diabetic rats
    Eugenia Padilla
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Diabetes Metab Res Rev 21:132-42. 2005
    Diabetic retinopathy (DR) is a highly specific vascular complication of type 1 and type 2 diabetes mellitus. Calcium dobesilate (DOBE) has been tested in the treatment of diabetic retinopathy showing a slowdown of the progression of the ..
  19. ncbi Evaluation of calcium dobesilate for its anti-cataract potential in experimental animal models
    T Velpandian
    Department of Ocular Pharmacology and Pharmacy, All India Institute of Medical Sciences, New Delhi, India
    Methods Find Exp Clin Pharmacol 32:171-9. 2010
    The present study evaluated the protective action of calcium dobesilate (CDO) in various experimental models of cataract. CDO was studied in hydrocortisone-induced cataract in developing chick embryos and selenite-induced cataract in pups...
  20. ncbi Calcium dobesilate for chronic venous insufficiency: a systematic review
    Agustin Ciapponi
    Family and Preventive Medicine Division, Hospital Italiano de Buenos Aires, Universidad de Buenos Aires, Argentina
    Angiology 55:147-54. 2004
    ..Many randomized clinical trials (RCTs) have shown a beneficial effect of calcium dobesilate, but consensus is lacking about efficacy and safety...
  21. ncbi [Protective effect of calcium dobesilate against early diabetic nephropathy of rat kidney]
    Mei Juan Gao
    Department of Endocrinology, Provincial Hospital affiliated to Shandong University, Jinan 250021, China
    Yao Xue Xue Bao 44:126-33. 2009
    The aim of this study is to study the effect of calcium dobesilate on streptozotocin (STZ)-induced early diabetic nephrophathy (DN) in rats...
  22. ncbi Reduction of retinal albumin leakage by the antioxidant calcium dobesilate in streptozotocin-diabetic rats
    Rossella Rota
    Children s Hospital Bambino Gesu, IRCCS, Rome, Italy
    Eur J Pharmacol 495:217-24. 2004
    b>Calcium dobesilate stabilizes blood-retinal barrier in patients with diabetic retinopathy and possesses antioxidant properties in the retinas of rats with streptozotocin-induced diabetes, exposed ex vivo to ischemia-reperfusion...
  23. ncbi Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment
    Lj Zivanovic
    Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, Vojvode Stepe 450, Belgrade, Serbia
    J Chromatogr A 1088:182-6. 2005
    ..and validated for simultaneous determination of lidocaine hydrochloride, dexamethasone acetate (DA) and calcium dobesilate (CD) in suppositories and ointment...
  24. ncbi Effect of calcium dobesilate on occurrence of diabetic macular oedema (CALDIRET study): randomised, double-blind, placebo-controlled, multicentre trial
    Christos Haritoglou
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Lancet 373:1364-71. 2009
    Medical treatment for diabetic retinopathy could have an important role in prevention of complications such as visual loss. We aimed to assess the effect of calcium dobesilate on occurrence of diabetic macular oedema.
  25. ncbi A randomized, double-blind multicentre clinical trial comparing the efficacy of calcium dobesilate with placebo in the treatment of chronic venous disease
    M J Martinez-Zapata
    Iberoamerican Cochrane Centre, Epidemiology and Public Health Service, Hospital de la Santa Creu i Sant Pau, Spain
    Eur J Vasc Endovasc Surg 35:358-65. 2008
    To assess the efficacy of calcium dobesilate on the quality-of-life (QoL) of patients with chronic venous disease (CVD).
  26. ncbi Randomized, double blind, placebo-controlled clinical trial to evaluate the lymphagogue effect and clinical efficacy of calcium dobesilate in chronic venous disease
    Fernando Flota-Cervera
    Centro de Diagnostico de Enfermedades Cardiovasculares, Merida, Yucatan, Mexico
    Angiology 59:352-6. 2008
    The aims of the present study were to investigate the effect of calcium dobesilate on lymph flow and lymphovenous edema in patients with chronic venous disease. It was a randomized, placebo-controlled, double-blind clinical trial...
  27. ncbi The effect of calcium dobesilate on vascular endothelial function, blood pressure, and markers of oxidation in obese male smokers: a placebo-controlled randomised clinical trial
    Miranda T Schram
    Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, Netherlands
    Atherosclerosis 170:59-72. 2003
    ..double-blind, placebo-controlled, clinical trial investigated the effect of 3 months of treatment with calcium dobesilate on endothelium-dependent vasodilation, markers of endothelial function, blood pressure, and markers of ..
  28. ncbi An ionic liquid-type carbon paste electrode for electrochemical investigation and determination of calcium dobesilate
    Jianbin Zheng
    Institute of Analytical Science, Shaanxi Provincial Key Lab of Electroanalytical Chemistry, Northwest University, Xi an, Shaanxi 710069, China
    Talanta 73:920-5. 2007
    ..The electrochemical responses of calcium dobesilate were investigated at the IL-CPE and the traditional carbon paste electrode (T-CPE) in 0...
  29. pmc Therapeutic effects of calcium dobesilate on diabetic nephropathy mediated through reduction of expression of PAI-1
    Xiaoqian Zhang
    Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, P R China
    Exp Ther Med 5:295-299. 2013
    The aim of this study was to investigate whether calcium dobesilate (calcium dihydroxy-2,5-benzenesulfonate) may be used to treat diabetic nephropathy...
  30. ncbi Drug-induced immune neutropenia/agranulocytosis
    Brian R Curtis
    PhD, D ABMLI, MT ASCP SBB, Director, Platelet and Neutrophil Immunology Lab, Blood Research Institute, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178
    Immunohematology 30:95-101. 2014
    ..Drugs most often associated with neutropenia or agranulocytosis include dipyrone, diclofenac, ticlopidine, calcium dobesilate, spironolactone, antithyroid drugs (e.g...
  31. ncbi [Evaluation of calcium dobesilate for its anti-cataract potential in experimental rat models]
    Guang ying Zheng
    Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China Email
    Zhonghua Yan Ke Za Zhi 49:927-33. 2013
    To investigate the preventive and therapeutic effects of agent calcium dobesilate(CDO) with different doses on the galactose cataract of rats.
  32. ncbi Modern management of hemorrhoidal disease
    Jason F Hall
    Department of Colon and Rectal Surgery, Lahey Clinic, 41 Mall Road, Burlington, MA 01805, USA Department of Surgery, Tufts University School of Medicine, 145 Harrison Avenue, Boston, MA 02111, USA Electronic address
    Gastroenterol Clin North Am 42:759-72. 2013
    ..This article reviews the pathophysiology of hemorrhoidal disease and the most commonly used techniques for the nonoperative and operative palliation of hemorrhoidal complaints. ..
  33. pmc Can calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?
    Sinan Demirtas
    Department of Cardiovascular Surgery, Medical School of Dicle University, Diyarbakir, Turkey
    Med Sci Monit Basic Res 19:253-7. 2013
    b>Calcium dobesilate (CaD) is a member of the synthetic veno-active drug family. Only a small number of reports are available that describe the micro-angiogenic effects of CaD in the current literature.
  34. ncbi Successive spectrophotometric resolution as a novel technique for the analysis of ternary mixtures of pharmaceuticals
    Hayam M Lotfy
    Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 121:313-23. 2014
    ..data related to the simultaneous spectrophotometric determination of lidocaine hydrochloride (LH), calcium dobesilate (CD) and dexamethasone acetate (DA); in the presence of hydroquinone (HQ), the degradation product of ..
  35. ncbi Chronic venous diseases: roles of various pathophysiological factors
    M R Boisseau
    Biologie Vasculaire, Laboratoire de Pharmacologie, Universite Victor Segalen Bordeaux 2, Carreire Nord, Bât 1A, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Clin Hemorheol Microcirc 31:67-74. 2004
    ..The aim of the present review is to assess the role of pathophysiological factors in CVD and the influence of different therapies, including the venotropic agent calcium dobesilate, on some of these haemodynamic or biochemical aspects.
  36. pmc Short-term efficacy of intravitreal dobesilate in central serous chorioretinopathy
    Pedro Cuevas
    Departamento de Investigacion, IRYCIS, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Eur J Med Res 17:22. 2012
    ..To report the anatomic and functional outcome of intravitreal dobesilate to treat recurrent central serous chorioretinopathy (CSC)...
  37. ncbi Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor
    Wenzhe Yang
    Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Street of Youanmenwai, 10 Xitoutiao, District of Feng Tai, Beijing 100069, PR China
    Exp Eye Res 115:96-105. 2013
    ..Here, by comparing with calcium dobesilate, the potent antioxidant compound currently used for the treatment of DR, we investigated the protective ..
  38. pmc Calcium dobesilate reduces endothelin-1 and high-sensitivity C-reactive protein serum levels in patients with diabetic retinopathy
    Alireza Javadzadeh
    Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
    Mol Vis 19:62-8. 2013
    To determine the benefits of calcium dobesilate (CaD) administration on endothelial function and inflammatory status in patients with diabetic retinopathy through measurement of serum levels of endothelin-1 and high-sensitivity C-reactive ..
  39. pmc Hemorrhoids: from basic pathophysiology to clinical management
    Varut Lohsiriwat
    Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    World J Gastroenterol 18:2009-17. 2012
    ..Some of the surgical treatments potentially cause appreciable morbidity such as anal stricture and incontinence. The applications and outcomes of each treatment are thoroughly discussed...
  40. ncbi Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats
    Lai Chun Lu
    Department of Pharmacy, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, PR China
    Planta Med 78:1317-23. 2012
    ..20 per group) and treated with intragastric doses of 30, 90, or 270 mg/kg/d wt of arctiin, 100 mg/kg/d wt of calcium dobesilate, or 0.5 % CMC-Na. Twenty nondiabetic sham-treated rats were treated with 0.5 % CMC-Na...
  41. ncbi Phlebotonics for haemorrhoids
    Nirmal Perera
    General Medicine, Addenbrookes Hospital, Cambridge, UK
    Cochrane Database Syst Rev 8:CD004322. 2012
    ..e. flavonoids) and synthetic compounds (i.e. calcium dobesilate)...
  42. ncbi Calcium dobesilate may improve hemorheology in patients undergoing coronary artery bypass grafting
    Kazim Besirli
    Cardiovascular Surgery Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Rev Bras Cir Cardiovasc 27:260-6. 2012
    b>Calcium dobesilate is an angioprotective agent that has positive effects on hemorheological parameters...
  43. ncbi Calcium dobesilate ameliorates lung injury following lower limb ischemia/reperfusion
    A K Bozkurt
    Department of Thoracic and Cardiovascular Surgery, Istanbul University, Cerrahpasa Medical Faculty, Turkey
    Drugs Exp Clin Res 28:127-32. 2002
    We examined the effects of calcium dobesilate on ameliorating the lung damage following ischemia-reperfusion injury in skeletal muscle of rats. A well known antioxidant, dimethyl sulfoxide, was also tested for comparison...
  44. ncbi Calcium dobesilate (Cd) in pigmented purpuric dermatosis (PPD): a pilot evaluation
    Subhav Kumar Agrawal
    Department of Dermatology and S T D, University College of Medical Sciences, Guru Teg Bahadur Hospital, New Delhi, India
    J Dermatol 31:98-103. 2004
    ..It is quite common, and no therapy is significantly effective. Calcium dobesilate (Cd) has been tried successfully in many vascular disorders...
  45. ncbi Diabetes impairs endothelium-dependent relaxation of human penile vascular tissues mediated by NO and EDHF
    Javier Angulo
    Fundación para la Investigación y el Desarrollo en Andrología 28304, Madrid, Spain
    Biochem Biophys Res Commun 312:1202-8. 2003
    ..b>Calcium dobesilate (DOBE; 10 microM) fully reversed diabetes-induced endothelial dysfunction in HPRA by specifically ..
  46. ncbi Determination of calcium dobesilate in human plasma using ion-pairing extraction and high-performance liquid chromatography
    K Rona
    Department of Internal Medicine, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary
    J Chromatogr B Biomed Sci Appl 755:245-51. 2001
    ..chromatographic method with ultraviolet absorbance detection has been developed for the determination of calcium dobesilate in human plasma...
  47. ncbi Flow-injection biamperometric direct determination of calcium dobesilate in irreversible couple system
    Jun Feng Song
    Institute of Analytical Science, Northwest University, Xi an 710069, China
    J Pharm Biomed Anal 33:789-96. 2003
    A flow-injection biamperometric method for direct determination of calcium dobesilate had been proposed based on biamperometric detection for irreversible couple...
  48. ncbi Pharmacological treatment in patients with C4, C5 and C6 venous disease
    M S Gohel
    Imperial Vascular Unit, Imperial College London, Charing Cross Hospital, London, UK
    Phlebology 25:35-41. 2010
    ..The aim of this review was to evaluate the evidence for pharmacological agents used for the treatment of chronic venous disease...
  49. ncbi Antiglioma effects of a new, low molecular mass, inhibitor of fibroblast growth factor
    Pedro Cuevas
    Servicio de Histologia, IRYCIS, E 28034 Madrid, Spain
    Neurosci Lett 491:1-7. 2011
    ..Moreover, this agent augments the efficiency of chemotherapeutic agents in a rat model of orthotopic brain tumor. These results suggest that 2,5DHPS treatment may represent a promising therapy for malignant glioma...
  50. ncbi An open trial of calcium dobesilate in patients with venous ulcers and stasis dermatitis
    Charandeep Kaur
    Department of Dermatology and Venereology, Government Medical College, Chandigarh, India
    Int J Dermatol 42:147-52. 2003
    ..Hence, there has been a renewal of interest in the medical management of varicose veins and ulcers. Calcium dobesilate, a capillotropic agent, has been found to be beneficial in the treatment of varicose veins.
  51. ncbi [Medical treatment of chronic venous disease: evolution or involution?]
    G B Agus
    Sezione di Chirurgia Vascolare e Angiologia, Dipartimento di Scienze Chirurgiche Specialistiche, Universita degli Studi di Milano, Milano, Italia
    Minerva Cardioangiol 59:285-98. 2011
    ..trials have used micronized purified flavonoid fraction; rutosides; escin; anthocyanosides; and synthetic calcium dobesilate. It was therefore surprising some recent difficulties in the use of this important treatment in health ..
  52. ncbi Risk of drug-induced agranulocytosis: the case of calcium dobesilate
    Pedro Zapater
    Unidad de Farmacología Clínica, Hospital General Universitario de Alicante, c o Maestro Alonso 109, 03010, Alicante, Spain
    Eur J Clin Pharmacol 58:767-72. 2003
    In the last 20 years, some cases of agranulocytosis associated with calcium dobesilate consumption in Spain have been reported...
  53. ncbi In vitro effect of calcium dobesilate on oxidative/inflammatory stress in human varicose veins
    O Alda
    Physiology and Pharmacology, School of Medicine of Zaragoza, Spain
    Phlebology 26:332-7. 2011
    To determine whether calcium dobesilate can act in chronic venous insufficiency by similar antioxidant, anti-inflammatory mechanisms as in diabetic retinopathy.
  54. ncbi Efficacy of calcium dobesilate in treating acute attacks of hemorrhoidal disease
    B B Mentes
    Public Health, Gazi University Medical School, Ankara, Turkey
    Dis Colon Rectum 44:1489-95. 2001
    A randomized, double-blind, controlled study was conducted to investigate the efficacy of oral calcium dobesilate therapy in treating acute attacks of internal hemorrhoids.
  55. ncbi [Risk of drug-induced agranulocytosis: an approximation to risk analysis arising from spontaneous notification of agranulocytosis cases among patients treated with calcium dobesilate]
    P Zapater Hernández
    Unidad de Farmacología Clínica, Hospital General Universitario de Alicante, C Maestro Alonso, 109, 03010 Alicante
    An Med Interna 19:275-82. 2002
    ..A new method to detect, using spontaneous reporting, increases in agranulocytosis risk among patients treated with calcium dobesilate is shown.
  56. ncbi Selective electrochemical sensing of calcium dobesilate based on the nano-Pd/CNTs modified pyrolytic graphite electrode
    Guangzhi Hu
    Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China
    Talanta 78:1211-4. 2009
    ..modified pyrolytic graphite electrode (PGE) has been fabricated for electrochemical sensing of calcium dobesilate (CD) in pharmaceutical capsules...
  57. ncbi Clinical evaluation of the efficacy and safety of calcium dobesilate in patients with chronic venous insufficiency of the lower limbs
    Adalberto Arceo
    Arzneimittelforschung BASF Pharma, Mexico City, Mexico
    Angiology 53:539-44. 2002
    ..b>Calcium dobesilate, from synthetic origin, has been shown to improve clinical symptoms of these venous conditions...
  58. ncbi Dobesilate inhibits the activation of signal transducer and activator of transcription 3, and the expression of cyclin D1 and bcl-XL in glioma cells
    P Cuevas
    Departamento de Investigacion, Hospital Universitario Ramon y Cajal, Universidad de Alcala de Henares, Madrid, Spain
    Neurol Res 28:127-30. 2006
    ..Because STAT3 signaling pathway plays pleiotropic roles in tumor proliferation, maintenance of STAT3 in its inactive state may prevent glioma growth and spreading...
  59. pmc Reduced intimal hyperplasia in rabbits via medical therapy after carotid venous bypass
    Semih Yucel
    Department of Cardiovascular Surgery, Ondokuz Mayis University Faculty of Medicine, 55139 Kurupelit, Samsun, Turkey
    Tex Heart Inst J 36:387-92. 2009
    ..We investigated the effects of clopidogrel, calcium dobesilate, nebivolol, and atorvastatin on the development of intimal hyperplasia in rabbits after carotid venous ..
  60. ncbi Effect of qiming granule on retinal blood circulation of diabetic retinopathy: a multicenter clinical trial
    Xiang xia Luo
    Department of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu, China
    Chin J Integr Med 15:384-8. 2009
    ..To objectively assess the effect of Qiming Granule in the treatment of diabetic retinopathy (DR) by fluorescence fundus angiography (FFA)...
  61. ncbi Attenuation of acute lung injury following lower limb ischemia/reperfusion: the pharmacological approach
    C Koksal
    Department of Cardiovascular Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Cardiovasc Surg (Torino) 47:445-9. 2006
    The purpose of this study was to examine the effects of N-acetylcysteine (NAC), calcium dobesilate (DOBE) and aprotinin on the amelioration of lung damage following ischemia/reperfusion injury in a rat hind limb model...
  62. ncbi A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options
    Uwe Wollina
    Department of Dermatology, Hospital Dresden Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Germany
    Int J Low Extrem Wounds 5:169-80. 2006
    ..flavonoids, red vine leaves extracts, total triterpenic fraction of Centella asiatica (L), prociadins, calcium dobesilate, and pentoxifylline...
  63. ncbi The effects of clopidogrel and calcium dobesilate on intimal hyperplasia following vascular injury
    T Cortelekoglu
    Department of Cardiovascular Surgery, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey
    Acta Chir Belg 106:206-10. 2006
    ..It has been proposed that clopidogrel and calcium dobesilate may play an important role in the amelioration of intimal hyperplasia...
  64. ncbi Dobesilate diminishes activation of the mitogen-activated protein kinase ERK1/2 in glioma cells
    P Cuevas
    Servicio de Histologia, Departamento de Investigacion, Hospital Universitario Ramon y Cajal, Ctra de Colmenar, Km 9 100, E 28034 Madrid Spain
    J Cell Mol Med 10:225-30. 2006
    ..This finding supports an important role for dobesilate in glioma growth, suggesting that dobesilate should be a treatment to be born in mind for glioma management...
  65. ncbi Cardioprotective effect of calcium dobesilate during open-heart surgery
    Ihsan Iskesen
    Department of Cardiovascular Surgery, Celal Bayar University School of Medicine, Manisa, Turkey
    Acta Cardiol 61:69-74. 2006
    ..controlled, prospective randomized study was to investigate the possible effects of the preoperative use of calcium dobesilate (CLS2210) on the biochemical markers of myocardial injury during open-heart surgery, and to determine if it ..
  66. ncbi Treatment of basal cell carcinoma with dobesilate
    Pedro Cuevas
    J Am Acad Dermatol 53:526-7. 2005
  67. ncbi Dihydroxy-2,5 benzenesulphonate (dobesilate) elicits growth arrest and apoptosis in glioma cells
    P Cuevas
    Departamento de Investigacion, Hospital Universitario Ramon y Cajal, Universidad de Alcala de Henares, Madrid, Spain
    Neurol Res 27:797-800. 2005
    ..In the present study we assessed the effects of dobesilate in rat glioma cells...
  68. ncbi Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy
    Han Kook Chung
    Research Institutes of Dong A Pharmaceutical Company, Kyunggi, Republic of Korea
    Arzneimittelforschung 55:573-80. 2005
    ..treated with antioxidants: troxerutin (trihydroxy-ethylrutoside, CAS 7085-55-4), Vaccinium myrtillus, and calcium dobesilate (hydroquinone calcium sulfonate, CAS 20123-80-2)...
  69. ncbi Drug treatment of haemorrhoids
    Mahesh C Misra
    Department of Surgery, All India Institute of Medical Sciences, New Delhi, India
    Drugs 65:1481-91. 2005
    ..The prime objective of drug therapy is to control the acute phase (bleeding) so that definitive therapy (banding, injection sclerotherapy, infrared photocoagulation, cryotherapy or surgery) can be scheduled at a convenient time...
  70. ncbi Effects of calcium dobesilate on glomerulus TIMP1 and collagen IV of diabetic rats
    Junwu Dong
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:416-8, 426. 2005
    To observe the effects of calcium dobesilate on the expression of glomerular tissue inhibitor of metalloproteinase 1 (TIMP1), collagen IV, and ultrastructure of glomerular basement membrane in diabetic rats, rats model of diabetes was ..
  71. ncbi Pharmacological treatments for basal cell carcinoma
    Seongmu Lee
    Division of Orbital and Ophthalmic Plastic and Reconstructive Surgery, and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Jules Stein Eye Institute, Los Angeles, California 90095 7006, USA
    Drugs 67:915-34. 2007
    ..Treatment of BCC with other agents, such as tazarotene, glycoalkaloid (BEC-5) cream, cidofovir and calcium dobesilate have been reported, but further studies are needed to ascertain the efficacy and adverse-effect profiles of ..
  72. ncbi Effect of calcium dobesilate on nephropathy in type 2 diabetic rats
    Xiaocheng Liu
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:36-8. 2005
    In order to investigate the effects and mechanisms of calcium dobesilate on renal lesions in experimental type 2 diabetic rats, dibetic rats were randomly divided into control group (group C) and experimental group (group D) treated with ..
  73. ncbi An electrochemical sensor for determination of calcium dobesilate based on PoPD/MWNTs composite film modified glassy carbon electrode
    Xiuhua Zhang
    Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, China
    J Biochem Biophys Methods 70:1203-9. 2008
    ..The electrochemical behavior of calcium dobesilate on PoPD/MWNTs modified electrode was also investigated...
  74. ncbi Chronic venous insufficiency of the lower limbs: suitability of transcutaneous blood gas monitoring as an endpoint to evaluate the outcome of pharmacological treatment with calcium dobesilate
    J Marinello
    Hospital General de Mataro, Mataro, Barcelona, Spain
    Methods Find Exp Clin Pharmacol 26:775-80. 2004
    This pilot clinical trial was designed to further investigate the effects of calcium dobesilate in the treatment of chronic venous insufficiency (CVI) by means of a novel endpoint, transcutaneous oxygen pressure (TcPO2), and to evaluate ..
  75. ncbi The effects of calcium dobesilate on the mechanical function of rat hearts
    I Cihan Ozbek
    Department of Cardiovascular Surgery, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    J Cardiovasc Surg (Torino) 50:395-401. 2009
    b>Calcium dobesilate is an angio-protective agent that has positive effects on hemorheological parameters. It decreases blood and plasma viscosity, thrombocyte aggregation, and microvascular hyperpermeability...
  76. ncbi Effects of calcium dobesilate and diosmin-hesperidin on apoptosis of venous wall in primary varicose veins
    E Iriz
    Gazi University, School of Medicine, Department of Cardiovascular Surgery, Ankara, Turkey
    Vasa 37:233-40. 2008
    Evaluation of the therapeutic effects of calcium dobesilate and diosmin-hesperidin through regulation of apoptosis.
  77. ncbi [Dobesilate Calcium in the treatment of chronic kidney failure]
    Xiao Cheng Liu
    Department of Nephrology, Affiliated Tongji Hospital, Tongji Medical College, Huazhong Science and Technological University, Wuhan 430030, China
    Zhonghua Yi Xue Za Zhi 84:1892-3. 2004
  78. pmc Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate
    T H Witney
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    Br J Cancer 103:1400-6. 2010
    ..The recent introduction of a dynamic nuclear polarisation technique has permitted noninvasive imaging of tumour cell metabolism in vivo following intravenous administration of (13)C-labelled cell substrates...
  79. ncbi Calcium dobesilate reduces oxidative stress in cardiac surgery
    M Cerrahoglu
    Department of Cardiovascular Surgery, Celal Bayar University School of Medicine Manisa, Turkey
    J Cardiovasc Surg (Torino) 50:695-701. 2009
    b>Calcium dobesilate (CD) is a synthetic benzene sulfonate derivative and an angioprotective agent used orally. It can be used in patients who have diabetic retinopathy or chronic venous insufficiency...
  80. ncbi Dobesilate in the treatment of plaque psoriasis
    Pedro Cuevas
    Servicio de Histologia, Departamento de Investigacion, Hospital Ramon y Cajal, Ctra de Colmenar, Km 9 100, E 28034 Madrid, Spain
    Eur J Med Res 10:373-6. 2005
    ..Topical dobesilate offers the potential for treatment of plaque psoriasis without atrophy or other local side effects associated with the use of topical corticosteroids...
  81. ncbi Calcium dobesilate-induced agranulocytosis
    L Duggal
    J Assoc Physicians India 53:320-1. 2005
  82. ncbi The effect of calcium dobesilate on venous function following saphenectomy in coronary artery bypass grafting
    Kerim Cagli
    Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
    Cardiovasc Revasc Med 7:212-6. 2006
    The aim of this study was to determine whether prophylactic use of calcium dobesilate (CD) can improve venous function after saphenous vein harvest in coronary artery bypass graft (CABG).