benzene derivatives

Summary

Top Publications

  1. ncbi Biofiltration and inhibitory interactions of gaseous benzene, toluene, xylene, and methyl tert-butyl ether
    Eun Hwa Shim
    Department of Environmental Science and Engineering, Ewha Womans University, Seoul 120 750, South Korea
    Environ Sci Technol 40:3089-94. 2006
  2. ncbi Tellurium tetrachloride and diphenyl ditelluride cause cytotoxicity in rat hippocampal astrocytes
    Shalini Roy
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Food Chem Toxicol 49:2564-74. 2011
  3. ncbi Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain
    J I Rossato
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, RS, Brasil
    Neurochem Res 27:297-303. 2002
  4. ncbi Diphenyl ditelluride targets brain selenoproteins in vivo: inhibition of cerebral thioredoxin reductase and glutathione peroxidase in mice after acute exposure
    Bruna Comparsi
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Mol Cell Biochem 370:173-82. 2012
  5. pmc Maternal exposure to ambient levels of benzene and neural tube defects among offspring: Texas, 1999-2004
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston 77030, USA
    Environ Health Perspect 119:397-402. 2011
  6. ncbi Assessment of the impact of the vehicular traffic on BTEX concentration in ring roads in urban areas of Bari (Italy)
    Maurizio Caselli
    Dipartimento di Chimica, Universita degli Studi di Bari, Via Orabona 4, Bari, Italy
    Chemosphere 81:306-11. 2010
  7. pmc Different functional roles of T1R subunits in the heteromeric taste receptors
    Hong Xu
    Senomyx, Inc, 11099 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:14258-63. 2004
  8. ncbi Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects
    Andressa Sausen de Freitas
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
    Neurosci Lett 503:1-5. 2011
  9. ncbi Mitochondrial electron transfer chain complexes inhibition by different organochalcogens
    Robson L Puntel
    Universidade Federal do Pampa Campus Uruguaiana BR 472 Km 7, Uruguaiana 97500 970, RS, Brazil
    Toxicol In Vitro 27:59-70. 2013
  10. ncbi Reduction of diphenyl diselenide and analogs by mammalian thioredoxin reductase is independent of their gluthathione peroxidase-like activity: a possible novel pathway for their antioxidant activity
    Andressa Sausen de Freitas
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, 97105 900, Santa Maria RS, Brazil
    Molecules 15:7699-714. 2010

Research Grants

  1. NEW SYNTHETIC APPLICATION OF BENZENE PHOTOCHEMISTRY
    Richard Johnson; Fiscal Year: 1990
  2. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
  3. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
  4. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
  5. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
  6. VOLATILE MARKERS OF PULMONARY TUBERCULOSIS IN THE BREATH
    Michael Phillips; Fiscal Year: 2006
  7. SYNTHESIS OF CYTOTOXIC GUAIANOLIDES AND OTHER TERPENOIDS
    JAMES RIGBY; Fiscal Year: 2006
  8. SYNTHESIS OF COCARCINOGENIC DITERPENES
    JAMES RIGBY; Fiscal Year: 2005
  9. VOLATILE MARKERS OF ORAL MALODOR IN THE BREATH
    Michael Phillips; Fiscal Year: 2004
  10. Ruthenium Catalyzed Bond Activation Reactions
    CHAE YI; Fiscal Year: 2006

Detail Information

Publications249 found, 100 shown here

  1. ncbi Biofiltration and inhibitory interactions of gaseous benzene, toluene, xylene, and methyl tert-butyl ether
    Eun Hwa Shim
    Department of Environmental Science and Engineering, Ewha Womans University, Seoul 120 750, South Korea
    Environ Sci Technol 40:3089-94. 2006
    ..These findings provide important new insights into biofiltration and may be used to improve the rational design of biofilters for remediation of petroleum gas-contaminated airstreams according to composition types of mixed gases...
  2. ncbi Tellurium tetrachloride and diphenyl ditelluride cause cytotoxicity in rat hippocampal astrocytes
    Shalini Roy
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Food Chem Toxicol 49:2564-74. 2011
    ..We conclude that DPDT and TeCl(4) are cytotoxic to astrocytes. TeCl(4) treated cells die via the intrinsic apoptotic pathway. Accumulation of tellurium occurs with both compounds, but results in different mechanisms of cell death...
  3. ncbi Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain
    J I Rossato
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, RS, Brasil
    Neurochem Res 27:297-303. 2002
    ..The compounds (AA-Te)2 and (PhS)2 have no antioxidant activity and pro-oxidant activity, respectively. These results suggest that (AA-Se)2 and (AA-S)2 can be considered as potential pharmaceutical antioxidant agents...
  4. ncbi Diphenyl ditelluride targets brain selenoproteins in vivo: inhibition of cerebral thioredoxin reductase and glutathione peroxidase in mice after acute exposure
    Bruna Comparsi
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Mol Cell Biochem 370:173-82. 2012
    ..In particular the inhibition of important selenoenzymes (TrxR and GPx) seems to be involved in the neurotoxicity associated with (PhTe)(2) exposure in adult mice...
  5. pmc Maternal exposure to ambient levels of benzene and neural tube defects among offspring: Texas, 1999-2004
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston 77030, USA
    Environ Health Perspect 119:397-402. 2011
    ..However, there have been no studies assessing the association between environmental levels of hazardous air pollutants, such as benzene, and neural tube defects (NTDs), a common and serious group of congenital malformations...
  6. ncbi Assessment of the impact of the vehicular traffic on BTEX concentration in ring roads in urban areas of Bari (Italy)
    Maurizio Caselli
    Dipartimento di Chimica, Universita degli Studi di Bari, Via Orabona 4, Bari, Italy
    Chemosphere 81:306-11. 2010
    ..The same concentration pattern and the correlation among BTEX levels in all sites confirmed the presence of a single source, the vehicular traffic, having a strong impact on air quality...
  7. pmc Different functional roles of T1R subunits in the heteromeric taste receptors
    Hong Xu
    Senomyx, Inc, 11099 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:14258-63. 2004
    ..Taken together, these findings demonstrate the different functional roles of T1R3 and T1R2 and the presence of multiple ligand binding sites on the sweet taste receptor...
  8. ncbi Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects
    Andressa Sausen de Freitas
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
    Neurosci Lett 503:1-5. 2011
    ..However, ebselen was not reduced by brain TrxR, indicating that the neuroprotective properties of this compound is possibly mediate by its glutathione peroxidase-like activity...
  9. ncbi Mitochondrial electron transfer chain complexes inhibition by different organochalcogens
    Robson L Puntel
    Universidade Federal do Pampa Campus Uruguaiana BR 472 Km 7, Uruguaiana 97500 970, RS, Brazil
    Toxicol In Vitro 27:59-70. 2013
    ..e., Ebs, (PhSe)(2) and (PhTe)(2) can oxidize critical thiol groups from mitochondrial complexes I and II. So, mitochondrial dysfunction can be considered an important factor in the toxicity of Ebs, (PhSe)(2) and (PhTe)(2)...
  10. ncbi Reduction of diphenyl diselenide and analogs by mammalian thioredoxin reductase is independent of their gluthathione peroxidase-like activity: a possible novel pathway for their antioxidant activity
    Andressa Sausen de Freitas
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, 97105 900, Santa Maria RS, Brazil
    Molecules 15:7699-714. 2010
    ....
  11. ncbi Effect of diphenyl diselenide, diphenyl ditelluride and ebselen on cerebral Na(+), K(+)-ATPase activity in rats
    V C Borges
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
    Toxicology 215:191-7. 2005
    ..Cerebral Na(+), K(+)-ATPase is a potential molecular target for the toxic effect of organochalcogens and the inhibition may occur through a change in the crucial thiol groups of this enzyme...
  12. ncbi Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice
    F C Meotti
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, SM, RS, CEP 97105 900, Santa Maria, Brazil
    Toxicol Lett 143:9-16. 2003
    ..LD(50) for all organochalcogens administrated in mice inhibited blood delta-ALA-D activity. The present study provides evidence for liver and renal toxicity of (PhTe)(2)...
  13. ncbi DNA damage in tissues and organs of mice treated with diphenyl diselenide
    Renato Moreira Rosa
    Departamento de Biofisica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul UFRGS, Avenida Bento Goncalves 9500, Bairro Agronomia, CEP 91501 970 Porto Alegre, RS, Brazil
    Mutat Res 633:35-45. 2007
    ..In summary, DPDS induces systemic genotoxicity in mammals as it causes DNA damage in vital organs like brain, liver, kidney and testes...
  14. ncbi Inhibitory effect of ebselen on lactate dehydrogenase activity from mammals: a comparative study with diphenyl diselenide and diphenyl ditelluride
    Thiago H Lugokenski
    Programa de Pos Graduacao em Bioquimica Toxicologica, Universidade Federal de Santa Maria, Santa Maria, Brasil
    Drug Chem Toxicol 34:66-76. 2011
    ..Our results also indicate that the use of LDH, as a marker of cell viability, may be biased by a direct inhibitory effect of ebselen or other chalcogenides on LDH, resulting in false protection in an in vitro system...
  15. ncbi Diphenyl diselenide induces apoptotic cell death and modulates ERK1/2 phosphorylation in human neuroblastoma SH-SY5Y cells
    Thais Posser
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, 97105 900, Brazil
    Arch Toxicol 85:645-51. 2011
    ..Pre-treatment with ERK1/2 inhibitor, U0126, increased cell susceptibility to (PhSe)(2). Together, these data indicate a cytotoxic potential of (PhSe)(2) in a neuronal cell line, which appears to be mediated by the ERK1/2 pathway...
  16. ncbi Convulsant effect of diphenyl diselenide in rats and mice and its relationship to plasma levels
    Marina Prigol
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
    Toxicol Lett 189:35-9. 2009
    ..p.>p.o.>s.c.), vehicle solutions (DMSO>canola oil) and animal species (mice>rat)...
  17. ncbi Mouse strain and quality control testing: improved sensitivity of the mouse embryo assay with embryos from outbred mice
    Zaraq Khan
    Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Fertil Steril 99:847-854.e2. 2013
    ..To determine the relative sensitivities of embryos from different strains of mice to in vitro stress...
  18. pmc Peroxides in mineral oil used for in vitro fertilization: defining limits of standard quality control assays
    Phoebe M Hughes
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Rochester, MN, USA
    J Assist Reprod Genet 27:87-92. 2010
    ..To determine the relative sensitivities of the 1 and 2-cell mouse embryo assays (MEA) and the human sperm motility assay (HSMA) for peroxides in mineral oil. The effect of peroxide on blastocyst cell number and apoptosis was also studied...
  19. pmc Isoform-specific antagonists of exchange proteins directly activated by cAMP
    Tamara Tsalkova
    Department of Pharmacology and Toxicology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 109:18613-8. 2012
    ..Isoform-specific EPAC pharmacological probes are highly desired and will be valuable tools for dissecting the biological functions of EPAC proteins and their roles in various disease states...
  20. ncbi Evaluation of the cytotoxicity, genotoxicity and mutagenicity of diphenyl ditelluride in several biological models
    Tiago Hoerbe Degrandi
    Departamento de Biofisica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Mutagenesis 25:257-69. 2010
    ..Our results suggest that the toxic and mutagenic properties of DPDT may stem from its ability to disturb the redox balance of the cell, which leads to oxidative stress and the induction of DNA damage...
  21. pmc Total syntheses of chelidonine and norchelidonine via an enamide-benzyne-[2 + 2] cycloaddition cascade
    Zhi Xiong Ma
    Department of Chemistry and Division of Pharmaceutical Sciences, University of Wisconsin, Madison, Wisconsin 53705, USA
    Org Lett 14:2742-5. 2012
    ..Total syntheses of chelidonine and norchelidonine featuring an enamide-benzyne-[2 + 2] cycloaddition initiated cascade is described. The cascade includes a pericyclic ring-opening and intramolecular Diels-Alder reaction...
  22. ncbi Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice
    Verônica B Brito
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, CAMPUS UNIVERSITRAIO CAMOBI, 97105 900 Santa Maria, RS, Brazil
    Brain Res Bull 68:414-8. 2006
    ..Our results indicate that the PTZ-induced chemical seizures and mortality was enhanced by (PhSe)(2) and BAL. These results indicated that (PhSe)(2) and BAL interact with PTZ possibly by modulating the GABAergic system...
  23. ncbi Antioxidant activity of diphenyl diselenide prevents the genotoxicity of several mutagens in Chinese hamster V79 cells
    Renato Moreira Rosa
    Departamento de Biofisica e Centro de Biotecnologia, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Mutat Res 631:44-54. 2007
    ..Our results clearly demonstrate that DPDS at low concentrations presents antimutagenic properties, which are most probably due to its antioxidant properties...
  24. ncbi Comparative deposition of diphenyl diselenide in liver, kidney, and brain of mice
    E N Maciel
    Department of Chemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Bull Environ Contam Toxicol 70:470-6. 2003
  25. ncbi Acute exposure of rabbits to diphenyl diselenide: a toxicological evaluation
    Marcos Raniel Straliotto
    Departamento de Bioquimica, Universidade Federal de Santa Catarina, Florianopolis, SC, 88040900, Brazil
    J Appl Toxicol 30:761-8. 2010
    ..These results indicated that acute toxicology to (PhSe)(2) in rabbit is dependent on the dose, which should motivate further experiments on the therapeutic properties of this compound...
  26. ncbi Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: involvement of oxidative stress and glutamatergic system
    Daniel H Roos
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Toxicol In Vitro 23:302-7. 2009
    ..In conclusion, endogenous purine (guanosine) and two synthetic organoselenium compounds can modulate the pro-oxidant effect of MeHg in cortical brain slices...
  27. pmc Unraveling the regulation of floral fragrance biosynthesis
    Thomas A Colquhoun
    Environmental Horticulture Department, University of Florida, Gainesville, FL, USA
    Plant Signal Behav 6:378-81. 2011
    ..The molecular puzzle is not complete, since the functions of the few FVBP transcription factors identified to date do not fully explain the transcriptional regulation of the entire gene network...
  28. ncbi Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides
    Jeroen D C Codée
    Leiden Institute of Chemistry, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Org Lett 5:1519-22. 2003
    ..The usefulness of this novel thiophilic activator is illustrated in a successful chemoselective glycosylation sequence in which the donor thioglycoside in the first condensation step may be either armed or disarmed. [reaction: see text]..
  29. ncbi Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice
    Andressa Sausen de Freitas
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900 RS, Brazil
    Brain Res Bull 79:77-84. 2009
    ..We posit that formation of a selenol intermediate, which possesses high nucleophilicity and high affinity for MeHg, accounts for the ability of diphenyl diselenide to ameliorate MeHg-induced toxicity...
  30. pmc Understanding in vivo benzenoid metabolism in petunia petal tissue
    Jennifer Boatright
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA
    Plant Physiol 135:1993-2011. 2004
    ....
  31. pmc A petunia chorismate mutase specialized for the production of floral volatiles
    Thomas A Colquhoun
    Department of Environmental Horticulture, and Plant Molecular and Cellular Biology, University of Florida, Gainesville, FL 32611, USA
    Plant J 61:145-55. 2010
    ..These results show that PhCM1 is the principal CHORISMATE MUTASE responsible for the coupling of metabolites from the shikimate pathway to the synthesis of FVBPs in the corolla of Petunia x hybrida cv. 'Mitchell Diploid'...
  32. ncbi Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste
    Peihua Jiang
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:15238-46. 2005
    ..In our model of T1R3's seven transmembrane helices, lactisole is predicted to dock to a binding pocket within the transmembrane region that includes these 4 key residues...
  33. ncbi Petunia floral volatile benzenoid/phenylpropanoid genes are regulated in a similar manner
    Thomas A Colquhoun
    Department of Environmental Horticulture, University of Florida, P O Box 110670, Gainesville, FL 32611, USA
    Phytochemistry 71:158-67. 2010
    ..One such feature is the highly regulated transcript accumulation of the FVBP genes. Additionally, ethylene may have a regulatory role in the FVBP system prior to a floral senescence program...
  34. ncbi The liaison of sweet and savory
    Veronica Galindo-Cuspinera
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 31:221-5. 2006
    ....
  35. pmc ODORANT1 regulates fragrance biosynthesis in petunia flowers
    Julian C Verdonk
    Department of Plant Physiology, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Plant Cell 17:1612-24. 2005
    ..Our studies identify ODO1 as a key regulator of floral scent biosynthesis...
  36. ncbi Phenotypic analysis of gene deletant strains for sensitivity to oxidative stress
    Vincent J Higgins
    Clive and Vera Ramaciotti Centre for Gene Function Analysis, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia
    Yeast 19:203-14. 2002
    ..Further analysis of these genes may reveal unknown mechanisms protecting the cell against reactive oxygen species...
  37. pmc Conversion of Bacillus subtilis OhrR from a 1-Cys to a 2-Cys peroxide sensor
    Sumarin Soonsanga
    Department of Microbiology, Wing Hall, Cornell University, Ithaca, NY 14853 8101, USA
    J Bacteriol 190:5738-45. 2008
    ..Rapid formation of intersubunit disulfide bonds protects OhrR against irreversible overoxidation in the presence of strong oxidants much more efficiently than do the endogenous low-molecular-weight thiols...
  38. ncbi OhrR, a transcription repressor that senses and responds to changes in organic peroxide levels in Xanthomonas campestris pv. phaseoli
    Warunya Panmanee
    Department of Biotechnology, Faculty of Sciences, Mahidol University, Bangkok, Thailand
    Mol Microbiol 45:1647-54. 2002
    ..Thus, OhrR is the first transcription repressor characterized that appeared to evolve to physiologically sense organic peroxides...
  39. ncbi Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo
    Hiroyuki Shibata
    Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Cancer Sci 100:956-60. 2009
    ..It was demonstrated that the number of beta-catenin-positive adenoma cells in Apc(580D/+) mice fed GO-Y030 was reduced...
  40. ncbi A combination of 3D-QSAR, docking, local-binding energy (LBE) and GRID study of the species differences in the carcinogenicity of benzene derivatives chemicals
    Filip Fratev
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Mol Graph Model 27:147-60. 2008
    ..and GRID methods was applied as a tool to study and predict the mechanism of action of 100 carcinogenic benzene derivatives. Two 3D-QSAR models were obtained: (i) model of mouse carcinogenicity on the basis of 100 chemicals (model ..
  41. ncbi Mechanism of ethylbenzene-induced mouse-specific lung tumor: metabolism of ethylbenzene by rat, mouse, and human liver and lung microsomes
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 107:352-66. 2009
    ....
  42. ncbi Ambient air levels of volatile organic compounds (VOC) and nitrogen dioxide (NO2) in a medium size city in Northern Spain
    M A Parra
    Laboratorio Integrado de Calidad Ambiental LICA, Departamento de Quimica y Edafologia, Facultad de Ciencias, Universidad de Navarra Irunlarrea 1, 31008, Pamplona, Navarra, Spain
    Sci Total Environ 407:999-1009. 2009
    ..The lowest levels of VOC and NO2 occurred during summer, owing to the increase in solar radiation and to lower traffic densities. Mean concentrations of benzene and NO2 exceeded the European limits at some of the monitored points...
  43. ncbi Atmospheric levels of BTEX compounds during the 2008 Olympic Games in the urban area of Beijing
    Junfeng Liu
    Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Sci Total Environ 408:109-16. 2009
    ..The extremely high ratios of ethylbenzene to m,p-xylene (E/X) were mainly observed at noontime in haze days, indicating that photochemical reactions were highly active under these typical days...
  44. ncbi A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures
    S Haddad
    Groupe de Recherche en Toxicologie Humaine (TOXHUM, , , Case Postale 6128, Succursale Centre-Ville, , , Canada
    Toxicol Sci 63:125-31. 2001
    ..The approaches developed in the present study permit, for the first time, the consideration of the impact of multichemical pharmacokinetic interactions at a quantitative level in mixture risk assessments...
  45. ncbi Oxidant-dependent switching between reversible and sacrificial oxidation pathways for Bacillus subtilis OhrR
    Sumarin Soonsanga
    Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
    Mol Microbiol 68:978-86. 2008
    ..Thus, depending on the oxidant, OhrR can be either reversibly oxidized or can instead function as a sacrificial regulator...
  46. pmc The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative
    Mayuree Fuangthong
    Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
    Proc Natl Acad Sci U S A 99:6690-5. 2002
    ..In the presence of organic hydroperoxides, OhrR is inactivated by the reversible oxidation of a single conserved cysteine residue to the corresponding cysteine-sulfenic acid, and perhaps to higher oxidation states...
  47. pmc Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor
    Marcel Winnig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    BMC Neurosci 6:22. 2005
    ..Using mutational analysis we investigated which amino acid residues distinguish lactisole insensitive rat from sensitive human T1R3 receptors...
  48. ncbi Quantum theoretic QSAR of benzene derivatives: some enzyme inhibitors
    Claudiu T Supuran
    Universita degli Studi, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, 1 50121, Florence, Italy
    J Enzyme Inhib Med Chem 19:237-48. 2004
    Our previously developed approach to the development of QSAR equations for benzene derivatives, originally for phenylalkylamine hallucinogens, has been applied to four new systems: sulfonamide inhibitors of the enzymes carbonic anhydrase,..
  49. pmc Efficient glycosidation of a phenyl thiosialoside donor with diphenyl sulfoxide and triflic anhydride in dichloromethane
    David Crich
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 7061, USA
    Org Lett 8:959-62. 2006
    ..With an excess of diphenyl sulfoxide, glycal formation can be completely suppressed and excellent yields are obtained for coupling to a wide range of primary, secondary, and tertiary acceptors...
  50. ncbi QSAR of benzene derivatives: comparison of classical descriptors, quantum theoretic parameters and flip regression, exemplified by phenylalkylamine hallucinogens
    Brian W Clare
    Department of Chemistry, The University of Western Australia, 35 Stirling Highway, Crawley, W A 6009, Australia
    J Comput Aided Mol Des 16:611-33. 2002
    A physical model of electronic effects in the QSAR of benzene derivatives, together with a regression technique for finding predictive equations, is presented...
  51. ncbi VOC in an urban and industrial harbor on the French North Sea coast during two contrasted meteorological situations
    Joelle Roukos
    Ecole des Mines de Douai, Departement Chimie et Environnement, Douai Cedex, France
    Environ Pollut 157:3001-9. 2009
    ..An atypical ratio of T/B in the summer samples led us to investigate the BTEX origins shedding light on the contribution of pollutants transported across various zones of VOC emissions situated in Europe...
  52. ncbi Spatial and temporal variation of BTEX in the urban atmosphere of Delhi, India
    Raza Rafiqul Hoque
    Department of Environmental Science, Tezpur University, Tezpur, India
    Sci Total Environ 392:30-40. 2008
    ..The inter-species ratios exhibit clear seasonal variations indicating differential reactivity of the VOC species in different seasons. Xylenes were found the largest contributor to the ozone formation followed by toluene...
  53. ncbi BTEX and MTBE adsorption onto raw and thermally modified diatomite
    Maria Aivalioti
    Technical University of Crete, Department of Environmental Engineering, Laboratory of Toxic and Hazardous Waste Management, University Campus, P C 73100, Chania, Crete, Greece
    J Hazard Mater 178:136-43. 2010
    ..The highest adsorption capacity, calculated through the values of the isotherm constant k(F), was obtained for MTBE (48.42 mg kg(-1) (mg/L)(n)) in sample D(950)...
  54. ncbi Efficient dehydrative sialylation of C-4-aminated sialyl-hemiketal donors with Ph2SO/Tf2O
    Deju Ye
    The Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People s Republic of China
    J Org Chem 74:1733-5. 2009
    ..By using a C-4-hindered non-nucleophilic amine auxiliary, excellent yields and high alpha-stereoselectivities were obtained for coupling with a wide range of primary and secondary acceptors...
  55. ncbi Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
    ..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers...
  56. ncbi Phase partitioning modeling of ethanol, isopropanol, and methanol with BTEX compounds in water
    Kenneth Y Lee
    Department of Civil and Environmental Engineering, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA 01854, USA
    Environ Pollut 154:320-9. 2008
    ..Comparison of experimentally-derived maximum single-phase water contents against UNIFAC-derived results shows good agreement for mixtures containing ethanol and methanol, but relatively poor agreement for mixtures containing isopropanol...
  57. ncbi Biodegradation kinetics of BTE-OX and MTBE by a diesel-grown biomass
    K Acuna-Askar
    Laboratorio de Biorremediacion Ambiental, Depto de Microbiologia, Facultad de Medicina, UANL, Madero Pte y Dr Aguirre Pequeno, Monterrey, NL, Mexico
    Water Sci Technol 53:197-204. 2006
    ..Substrate percent removals ranged between 64.8-98.9% for benzene, toluene and ethylbenzene. O-xylene and MTBE percent removals ranged between 18.7-40.8% and 7.2-10.3%, respectively...
  58. ncbi Ambient BTEX and MTBE in the neighborhoods of different industrial parks in Southern Taiwan
    Lien Te Hsieh
    Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, Nei Pu 912, Ping Tung 91201
    J Hazard Mater 128:106-15. 2006
    ..Furthermore, principal component analysis also confirmed that the dominant influences in the six different industrial park neighborhoods were related to the emissions of MTBE, benzene and toluene...
  59. ncbi Benzene and its methyl-derivatives: derivation of maximum exposure levels in automobiles
    Thomas Schupp
    Elastogran, Department for Ecology and Product Safety, Lemförde, Germany
    Toxicol Lett 160:93-104. 2006
    ..A systematic toxicological evaluation of the risk associated with benzene exposure in cars seems to be necessary...
  60. ncbi Background atmospheric levels of aldehydes, BTEX and PM10 pollutants in a medium-sized city of southern Italy
    Pasquale Iovino
    Dipartimento di Scienze Ambientali, Seconda Universita di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Ann Chim 97:597-604. 2007
    ..90). At weekends the concentrations were lower by about 1.6 times. Both on weekdays and at weekends the PM10 and benzene levels exceeded the limits set by the EU Directive 30/1999 and 69/2000, respectively...
  61. ncbi PCR-DGGE method to assess the diversity of BTEX mono-oxygenase genes at contaminated sites
    Barbara Hendrickx
    Environmental and Process Technology, Flemish Institute for Technological Research VITO, Mol, Belgium
    FEMS Microbiol Ecol 55:262-73. 2006
    ....
  62. ncbi Liquid-liquid extraction/headspace/gas chromatographic/mass spectrometric determination of benzene, toluene, ethylbenzene, (o-, m- and p-)xylene and styrene in olive oil using surfactant-coated carbon nanotubes as extractant
    Carolina Carrillo-Carrión
    Department of Analytical Chemistry, Marie Curie Building Annex, Campus de Rabanales, University of Cordoba, E 14071 Cordoba, Spain
    J Chromatogr A 1171:1-7. 2007
    ..Limits of detection were in the range 0.25 ng mL(-1) (obtained for ethylbenzene) and 0.43 ng mL(-1) (for benzene). The repeatability of the proposed method expressed as RSD varied between 1.9% (styrene) and 3.3% (benzene) (n=11)...
  63. ncbi Field study of pulsed air sparging for remediation of petroleum hydrocarbon contaminated soil and groundwater
    Xiaomin Yang
    BP p l c, 28100 Torch Parkway, Warrenville, Illinois 60555, USA
    Environ Sci Technol 39:7279-86. 2005
    ..Among BTEX, benzene's reduction rate was the highest during the pulsed air-sparging operation...
  64. ncbi [Different models and a certain methodological unity]
    César Hernández-Rodríguez
    Escuela Nacional de Ciencias Biologicas IPN, DF, Mexico
    Rev Latinoam Microbiol 48:211-25. 2006
    ..The papers explain several questions and exhibit different perspectives, but maintain a methodological unit, illustrating the knowledge and applicative potential of microbial ecology from a molecular point of view...
  65. ncbi Enumeration of aromatic oxygenase genes to evaluate monitored natural attenuation at gasoline-contaminated sites
    Brett R Baldwin
    School of Civil Engineering, Purdue University, West Lafayette, IN 47907 1284, USA
    Water Res 42:723-31. 2008
    ..The combination of trend analysis of contaminant concentrations with quantification of aromatic oxygenase genes was used to assess the feasibility of MNA as corrective measures at both sites...
  66. ncbi Anaerobic BTEX biodegradation linked to nitrate and sulfate reduction
    Junfeng Dou
    Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, PR China
    J Hazard Mater 151:720-9. 2008
    ..51, 4.33, 4.89, 4.81, 4.86 and 4.76, respectively, which were nearly the same to theoretical ones, and the relative error between the measured and calculated ratios was less than 10%...
  67. ncbi Combined removal of BTEX in air stream by using mixture of sugar cane bagasse, compost and GAC as biofilter media
    Anil K Mathur
    Chemical Engineering Department, Indian Institute of Technology Roorkee, Roorkee 247667, India
    J Hazard Mater 148:64-74. 2007
    ..A Gram-positive strain had a high BTEX-degrading activity and was identified as Bacillus sphaericus by taxonomical analysis, biochemical tests and 16S rDNA gene analysis methods...
  68. ncbi S5 Lipase: an organic solvent tolerant enzyme
    Raja Noor Zaliha Abdul Rahman
    Enzyme and Microbial Technology Research, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    J Microbiol 44:583-90. 2006
    ..The absence of magnesium ions (Mg2+) in the basal medium was also shown to stimulate lipase production. Meanwhile, an alkaline earth metal ion, Na+, was found to stimulate the production of S5 lipase...
  69. ncbi Atmospheric levels of aldehydes and BTEX and their relationship with vehicular fleet changes in Rio de Janeiro urban area
    Eduardo Monteiro Martins
    Departamento de Fisico Quimica, Instituto de Química da UFRJ CT, Bloco A, Sala 408, Cidade Universitária Rio de Janeiro, RJ, 21949 900, Brazil
    Chemosphere 67:2096-103. 2007
    ..The levels of ethylbenzene and xylenes determined in this work are similar to values obtained in 1996. This fact may be explained as a consequence of changes in the gasoline composition...
  70. ncbi Isolation, gene detection and solvent tolerance of benzene, toluene and xylene degrading bacteria from nearshore surface water and Pacific Ocean sediment
    Lin Wang
    Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, State Oceanic Administration, Daxue Road 178, Xiamen 361005, Fujian, People s Republic of China
    Extremophiles 12:335-42. 2008
    ..Results in this report suggested that BTX degrading bacteria widely spread in marine environments and they might be of potentials in biotreatment of BTEX in saline environments...
  71. ncbi In situ bioremediation of groundwater contaminated with petroleum constituents using oxygen release compounds (ORCs)
    Yasemin Kacar Kunukcu
    Shaw Group Inc, 101 1 Colin Drive Holbrook, NY 11741, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 42:839-45. 2007
    ..The compound with the highest biodegradation rate constant was m,p-xylene in monitoring wells MW-2, MW-3 and MW-4...
  72. ncbi Applicability of stable isotope fractionation analysis for the characterization of benzene biodegradation in a BTEX-contaminated aquifer
    Anko Fischer
    Department of Isotope Biogeochemistry, UFZ Centre for Environmental Research Leipzig Halle, Permoserstr 15, D 04318 Leipzig, Germany
    Environ Sci Technol 41:3689-96. 2007
    ....
  73. ncbi Characterization of solid-phase microextraction and gas chromatography for the analysis of gasoline tracers in different microenvironments
    Diana Ceballos
    University of Washington, Seattle, WA, USA
    J Air Waste Manag Assoc 57:355-65. 2007
    ..SPME data compared satisfactorily with integrated canister samples, continuous PID, and field portable mass spectrometer data...
  74. ncbi Metabolism of BTEX and naphtha compounds to methane in oil sands tailings
    Tariq Siddique
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Environ Sci Technol 41:2350-6. 2007
    ..Current study findings could influence extraction process, MFT management, and reclamation options...
  75. ncbi Studies on commuters' exposure to BTEX in passenger cars in Kolkata, India
    D Som
    Department of Chemistry, University College of Science Technology and Agriculture, 92, A P C Road, Kolkata 700 009, India
    Sci Total Environ 372:426-32. 2007
    ..4 microg/m3. The in-vehicle concentration varied with engine type and age of the vehicle. Roadside ambient mean concentration of benzene was 214.8 microg/m3 and 30.8 microg/m3 in Phase I and Phase II respectively...
  76. ncbi Nano-structured lead dioxide as a novel stationary phase for solid-phase microextraction
    Ali Mehdinia
    Department of Chemistry, Tarbiat Modares University, P O Box 14115 175, Tehran, Iran
    J Chromatogr A 1134:24-31. 2006
    ..Higher chemical resistance and lower cost are among the advantages of PbO2 fibers over commercially available SPME fibers. Good recoveries (81-108%) were obtained when environmental samples were analyzed...
  77. ncbi Benzene, toluene, ethylbenzene, and isomeric xylenes in various water samples in Croatia
    B Karaconji
    Clinical Toxicological Chemistry Unit, Institute for Medical Research and Occupational Health, Ksaverska c 2, Post Office Box 291, HR 10001 Zagreb, Croatia
    Bull Environ Contam Toxicol 76:458-62. 2006
  78. ncbi Application of in situ biosparging to remediate a petroleum-hydrocarbon spill site: field and microbial evaluation
    C M Kao
    Institute of Environmental Engineering, National Sun Yat Sen University, Kaohsiung, Taiwan
    Chemosphere 70:1492-9. 2008
    ..This indicates that biosparging is a promising technology to remediate BTEX contaminated groundwater...
  79. ncbi Anaerobic BTEX degradation in soil bioaugmented with mixed consortia under nitrate reducing conditions
    Junfeng Dou
    College of Water Sciences, Beijing Normal University, Beijing 100875, China
    J Environ Sci (China) 20:585-92. 2008
    ....
  80. ncbi Sulfur and oxygen isotope fractionation during benzene, toluene, ethyl benzene, and xylene degradation by sulfate-reducing bacteria
    Kay Knoller
    Departments of Isotope Hydrology and Isotope Biogeochemistry, Umweltforschungszentrum Centre for Environmental Research Leipzig Halle, Theodor Lieser Strasse 4, 06120 Halle Saale, Germany
    Environ Sci Technol 40:3879-85. 2006
    ..The dual isotope approach enables the identification of such sulfur transformation processes. This identification is vital for a general qualitative evaluation of the natural attenuation potential of the contaminated aquifer...
  81. ncbi Risk factors for increased BTEX exposure in four Australian cities
    Andrea L Hinwood
    Centre for Ecosystem Management, School of Natural Sciences, Edith Cowan University, 100 Joondalup Drive, Joondalup, Western Australia 6027, Australia
    Chemosphere 66:533-41. 2007
    ....
  82. ncbi A multitracer test proving the reliability of Rayleigh equation-based approach for assessing biodegradation in a BTEX contaminated aquifer
    Anko Fischer
    UFZ Center for Environmental Research Leipzig Halle, Department of Isotope Biogeochemistry, Permoserstrasse 15, D 04318 Leipzig, Germany
    Environ Sci Technol 40:4245-52. 2006
    ..This method indicated that parts of deuterium were assimilated into the biomass of toluene degrading microorganisms...
  83. ncbi Simultaneous determination of methyl tert-butyl ether, its degradation products and other gasoline additives in soil samples by closed-system purge-and-trap gas chromatography-mass spectrometry
    Monica Rosell
    Department of Environmental Chemistry, IIQAB CSIC, Jordi Girona 18 26, 08034 Barcelona, Catalonia, Spain
    J Chromatogr A 1132:28-38. 2006
    ..The proposed method provides the directions for the future application on real samples in current monitoring programs at gasoline pollution risk sites where till now little monitoring data for MTBE in soils are available...
  84. ncbi Headspace-mass spectrometry determination of benzene, toluene and the mixture of ethylbenzene and xylene isomers in soil samples using chemometrics
    F A Esteve-Turrillas
    Department of Analytical Chemistry, Universitat de Valencia, Edifici Jeroni Muñoz, 50th Dr Moliner, 46100 Burjassot, Valencia, Spain
    Anal Chim Acta 587:89-96. 2007
    ..So, the developed procedure allowed a fast identification and prediction of BTEX present in the samples without a prior chromatographic separation...
  85. pmc Dynamics of an oligotrophic bacterial aquifer community during contact with a groundwater plume contaminated with benzene, toluene, ethylbenzene, and xylenes: an in situ mesocosm study
    Barbara Hendrickx
    Environmental and Process Technology, Flemish Institute for Technological Research, 2400 Mol, Belgium
    Appl Environ Microbiol 71:3815-25. 2005
    ..Our results indicate that communities with long-term stability in their structures follow the contamination plume and rapidly colonize downstream areas upon contamination...
  86. pmc Anaerobic degradation of benzene, toluene, ethylbenzene, and o-xylene in sediment-free iron-reducing enrichment cultures
    Michael K Jahn
    Lehrstuhl Umweltmineralogie, Zentrum für Angewandte Geowissenschaften, Eberhard Karls Universitat Tubingen, Germany
    Appl Environ Microbiol 71:3355-8. 2005
    ..The electron balances showed a complete anaerobic oxidation of the aromatic compounds to CO2. This is the first report on the anaerobic degradation of o-xylene and ethylbenzene in sediment-free iron-reducing enrichment cultures...
  87. ncbi Remediation of BTEX and trichloroethene. Current knowledge with special emphasis on phytoremediation
    Chris Collins
    Department of Environmental Science and Technology, Imperial College of Science Technology and Medicine, Prince Consort Road, London, SW7 2BP, UK
    Environ Sci Pollut Res Int 9:86-94. 2002
    ....
  88. ncbi Field-based supercritical fluid extraction of hydrocarbons at industrially contaminated sites
    Peggy Rigou
    Cranfield Centre for Analytical Science, Cranfield University at Silsoe, Silsoe, Bedfordshire, MK45 4DT, UK
    ScientificWorldJournal 2:1063-9. 2002
    ..The device will next be evaluated with real samples prior to field deployment...
  89. ncbi Simultaneous determination of fuel oxygenates and BTEX using direct aqueous injection gas chromatography mass spectrometry (DAI-GC/MS)
    Luc Zwank
    Swiss Federal Institute for Environmental Science and Technology EAWAG, Dubendorf
    Environ Sci Technol 36:2054-9. 2002
    ..The applications comprised both laboratory (MTBE degradation in water treatment, quantification of polar gasoline components) and field (MTBE degradation ata gasoline spill site) investigations...
  90. pmc Enhanced anaerobic biodegradation of benzene-toluene-ethylbenzene-xylene-ethanol mixtures in bioaugmented aquifer columns
    Marcio L B Da Silva
    Department of Civil and Environmental Engineering, Rice University, MS 317, Houston, TX 77251 1892, USA
    Appl Environ Microbiol 70:4720-6. 2004
    ..This approach may be especially attractive for removing benzene, which is the most toxic and commonly the most persistent BTEX compound under anaerobic conditions...
  91. ncbi Effect of benzene, toluene, ethylbenzene, and p-xylene (BTEX) mixture on biodegradation of methyl tert-butyl ether (MTBE) and tert-butyl alcohol (TBA) by pure culture UC1
    Amy Pruden
    Department of Civil and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221, USA
    Biodegradation 15:213-27. 2004
    ..In addition to exploring the affect of BTEX, this study also provides general insight into the metabolism of MTBE and TBA by pure culture UC1...
  92. ncbi Biodegradation of methyl tert-butyl ether and BTEX at varying hydraulic retention times
    Marie A Sedran
    Department of Civil and Environmental Engineering, University of Cincinnati, Ohio 45221 0071, USA
    Water Environ Res 76:47-55. 2004
    ..Batch studies also showed that the rate of degradation of TBA was higher with and without BTEX than the rate of degradation of MTBE, explaining the lack of high levels of TBA in the reactor...
  93. ncbi Environmental exposure of commuters in Mexico City to volatile organic compounds as assessed by blood concentrations, 1998
    Sharon Lemire
    Division of Laboratory Sciences, National Center for Environmental Health Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Salud Publica Mex 46:32-8. 2004
    ..To assess the extent of exposure for Volatile Organic Compounds (VOCs) among nonoccupationally exposed commuters in Mexico City...
  94. ncbi Bioremediation of BTEX hydrocarbons: effect of soil inoculation with the toluene-growing fungus Cladophialophora sp. strain T1
    F X Prenafeta-Boldú
    Centraalbureau voor Schimmelcultures, Institute of the Royal Netherlands Academy of Arts and Sciences, P O Box 85167, 3508 AD Utrecht, The Netherlands
    Biodegradation 15:59-65. 2004
    ..The presence of the fungal inoculum at the end of the experiments was confirmed by PCR-TGGE analysis of small subunits of 18S rDNA...
  95. ncbi [A study of groundwater contamination with organic fuels and potential public health impact in Itaguaí, Rio de Janeiro State, Brazil]
    Rosimar Lima Brandão Silva
    Departamento de Saneamento e Saúde Ambiental, Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ 21041 210, Brasil
    Cad Saude Publica 18:1599-607. 2002
    ..L-1. Four others wells were also contaminated with nitrate, responsible for the induction of methemoglobinemia. Natural attenuation (intrinsic biodegradation) mechanisms through electron acceptors was also investigated in this study...
  96. ncbi Mesophilic and thermophilic BTEX substrate interactions for a toluene-acclimatized biofilter
    J M Strauss
    School for Environmental Sciences and Development Microbiology, Potchefstroom University for Christian Higher Education, Private Bag X6001, Potchefstroom 2520, South Africa
    Appl Microbiol Biotechnol 64:855-61. 2004
    ....
  97. ncbi Detection of benzene, toluene, ethyl benzene, and xylenes (BTEX) using toluene dioxygenase-peroxidase coupling reactions
    Zhaohui Xu
    Department of Chemical and Environmental Engineering, University of California, Riverside, California 92521, USA
    Biotechnol Prog 19:1812-5. 2003
    ..The excellent stability suggests that the reported bioassay may be suitable for field monitoring of BTEX to identify and track contaminated water and follow the bioremediation progress...
  98. ncbi Intrinsic bioremediability of an aromatic hydrocarbon-polluted groundwater: diversity of bacterial population and toluene monoxygenase genes
    L Cavalca
    Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universita degli Studi di Milano, Via Celoria 2, 20133 Milan, Italy
    Appl Microbiol Biotechnol 64:576-87. 2004
    ..The presence of different tmo-like genes in phylogenetically distant strains of Pseudomonas, Mycobacterium and Bradyrhizobium suggested recent horizontal gene transfer in the groundwater...
  99. ncbi Monitoring of the gasoline oxygenate MTBE and BTEX compounds in groundwater in Catalonia (northeast Spain)
    J Fraile
    Catalan Water Agency Agència Catalana de l Aigua, Ministry of Environmental Affairs, Generalitat de Catalunya, Provença 204 208, 08036 Barcelona, Spain
    ScientificWorldJournal 2:1235-42. 2002
    ....
  100. ncbi Kinetics of natural attenuation of BTEX: review of the critical chemical conditions and measurements at bore scale
    O Atteia
    EGID Institute, Bordeaux 3 University, 1 Allée Daguin 33607 Pessac Cedex, France
    ScientificWorldJournal 2:1338-46. 2002
    ..First results of biodegradation show that this technique is able to easily detect the degradation of 1 mg/l of hydrocarbons and that, in oxic media, a fast degradation rate of mixed fuel is observed...
  101. ncbi Assessment of microbial natural attenuation in groundwater polluted with gasworks residues
    S Schulze
    Department of Environmental Biotechnology, Water Technology Center, 76139 Karlsruhe, Germany
    Water Sci Technol 50:347-53. 2004
    ..The microcosm studies in particular were suitable to examine the role of specific electron acceptors, and represented an important component of the multiple line of evidence concept to assess natural attenuation...

Research Grants38

  1. NEW SYNTHETIC APPLICATION OF BENZENE PHOTOCHEMISTRY
    Richard Johnson; Fiscal Year: 1990
    ..research will explore the limitations and synthetic potential of several photochemical reactions of benzene derivatives, with the goal of providing new or improved approaches to polycyclic molecules such as natural products, ..
  2. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  3. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  4. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  5. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  6. VOLATILE MARKERS OF PULMONARY TUBERCULOSIS IN THE BREATH
    Michael Phillips; Fiscal Year: 2006
    ..Also, it could potentially reduce the mortality and morbidity caused by pulmonary TB. [unreadable] [unreadable] [unreadable]..
  7. SYNTHESIS OF CYTOTOXIC GUAIANOLIDES AND OTHER TERPENOIDS
    JAMES RIGBY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. SYNTHESIS OF COCARCINOGENIC DITERPENES
    JAMES RIGBY; Fiscal Year: 2005
    ..These projected investigations should generate substantial new knowledge about complex synthesis as well as providing additional insight into some of the bioactivity exhibited by the subject natural products. ..
  9. VOLATILE MARKERS OF ORAL MALODOR IN THE BREATH
    Michael Phillips; Fiscal Year: 2004
    ....
  10. Ruthenium Catalyzed Bond Activation Reactions
    CHAE YI; Fiscal Year: 2006
    ..The proposed research will provide new catalytic methods for the synthesis of anticancer drugs and anti-inflammatory agents. [unreadable] [unreadable] [unreadable]..
  11. Purchase of a 600 MHz NMR Spectrometer with Cryoprobe
    DENNIS CURRAN; Fiscal Year: 2007
    ..This research often requires sophisticated NMR experiments on small samples, and the requested 600 MHz spectrometer will greatly expedite ongoing and planned work. [unreadable] [unreadable] [unreadable]..
  12. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  13. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  14. Intramolecular Aryne Cycloadditions and Rearrangements
    KEITH BUSZEK; Fiscal Year: 2008
    ..abstract_text> ..
  15. Synthesis of anticancer agents using Prins cyclization
    Scott Rychnovsky; Fiscal Year: 2007
    ..These tools will facilitate the synthesis of many new structures that may be important as new pharmaceutical agents. ..
  16. EARLY HUSBANDRY INFLUENCES ON ADULT PHENOTYPE
    MICHAEL TORDOFF; Fiscal Year: 2009
    ..The results will lead to better environmental controls in future work and, asa direct consequence, easierand more rapid progress with genetic analyses. ..
  17. Carcinogenicity of Estrogens
    DAVID SPINK; Fiscal Year: 2009
    ..These studies may elucidate roles of estrogen in the regulation of Ah responsiveness, CYP1 expression, and carcinogen bioactivation that may lead to novel breast cancer chemoprevention strategies. ..
  18. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  19. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed. ..
  20. SPECT Imaging of Abeta Plaques in Brain
    Mei Ping Kung; Fiscal Year: 2006
    ..The At3-plaque-specific imaging agents will be useful for early detection or monitoring the progression and effectiveness of treatment of AD. ..
  21. Oligopyrrole-based Anion Binding Agents
    Jonathan L Sessler; Fiscal Year: 2010
    ..abstract_text> ..
  22. FLUOROUS METHODS FOR TRADITIONAL AND PARALLEL SYNTHESIS
    DENNIS CURRAN; Fiscal Year: 2003
    ..In short, the work will help to move the very young field of fluorous chemistry from infancy into childhood. ..
  23. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  24. Medicinal Inorganic Chemistry ACS Symposium F-2003
    Jonathan Sessler; Fiscal Year: 2003
    ..It is thus expected that the present MIC-ACS symposium will afford a unique opportunity to develop further growth in a field of study that is rich in opportunity and central to the NIH mission. ..
  25. Acquisition of a 500 MHz NMR Spectrometer
    Scott Rychnovsky; Fiscal Year: 2004
    ..This new instrument will bring much needed new capabilities to the NMR facility and will greatly facilitate the research programs of the PI and co-PIs of this proposal. ..
  26. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  27. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  28. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  29. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  30. Alkyllithium Cyclizations in Organic Snythesis
    Scott Rychnovsky; Fiscal Year: 2005
    ..These compounds are of interest to synthetic and medicinal chemists, and have the types of rigid, polycyclic and polar structures found to show high bioactivity in many assays. ..
  31. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  32. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  33. RADICAL REACTIONS FOR NATURAL PRODUCTS
    DENNIS CURRAN; Fiscal Year: 2002
    ....
  34. Measurement of pain-suppressed behaviors in rodent models of chronic pain
    GLENN STEVENSON; Fiscal Year: 2007
    ..This strategy will complement the more traditional procedures for assessing pain and antinociceptive activity, and help in the development of safer and more effective treatments for chronic pain. [unreadable] [unreadable] [unreadable]..
  35. Hazardous Air Pollutants and Lymphohematopoietic Cancer Incidence in Houston 1995
    Elaine Symanski; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ....
  37. Study of the Strength of CH-Y (Y =O,N)and XH-pi (X=N,O,S) Interactions
    BENJAMIN GUNG; Fiscal Year: 2006
    ..The understanding of these weak interactions is essential for rational drug design and lead optimization. [unreadable] [unreadable]..
  38. STRUCTURE/FUNCTION OF MITOCHONDRIAL CITRATE CARRIER
    RONALD KAPLAN; Fiscal Year: 2009
    ..Consequently, an elucidation of the structural basis for substrate transport through the CTP is critical to understanding the CTP's role in energy production in normal and pathological states. ..