aromatic hydrocarbons

Summary

Summary: Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.

Top Publications

  1. ncbi Phenyl-modified reversed-phase liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry: a universal method for the analysis of partially oxidized aromatic hydrocarbons
    T Letzel
    Institute of Hydrochemistry, Technical University of Munich, Germany
    Anal Chem 73:1634-45. 2001
  2. ncbi Ability of polycyclic aromatic hydrocarbons to induce 7-ethoxyresorufin-o-deethylase activity in a trout liver cell line
    N C Bols
    Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
    Ecotoxicol Environ Saf 44:118-28. 1999
  3. ncbi Monitoring aromatic hydrocarbons by whole cell electrochemical biosensors
    Yossi Paitan
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Anal Biochem 335:175-83. 2004
  4. ncbi The effect of aliphatic, naphthenic, and aromatic hydrocarbons on production of reactive oxygen species and reactive nitrogen species in rat brain synaptosome fraction: the involvement of calcium, nitric oxide synthase, mitochondria, and phospholipase A
    O Myhre
    Norwegian Defence Research Establishment, Division for Protection and Material, P.O. Box 25, N-2027, Kjeller, Norway
    Biochem Pharmacol 62:119-28. 2001
  5. ncbi Application of a fiber-optic NIR-EFA sensor system for in situ monitoring of aromatic hydrocarbons in contaminated groundwater
    J Buerck
    Forschungszentrum Karlsruhe, Institut für Instrumentelle Analytik, P O Box 3640, D 76021 Karlsruhe, Germany
    J Hazard Mater 83:11-28. 2001
  6. ncbi Evolution of occupational exposure to environmental levels of aromatic hydrocarbons in service stations
    J F Periago
    Instituto de Seguridad y Salud Laboral, c Lorca 70, 30120 El Palmar, Murcia, Spain
    Ann Occup Hyg 49:233-40. 2005
  7. ncbi Determinants of polychlorinated aromatic hydrocarbons in serum in three age classes--Methodological implications for human biomonitoring
    Elly Den Hond
    Flemish Institute of Technological Research VITO, Environmental Toxicology, Boeretang 200, Mol 2400, Belgium
    Environ Res 109:495-502. 2009
  8. ncbi Functional genomics of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1
    Ralf Rabus
    Max Planck Institut für Marine Mikrobiologie, Bremen, Germany
    Appl Microbiol Biotechnol 68:580-7. 2005
  9. pmc Outer-membrane transport of aromatic hydrocarbons as a first step in biodegradation
    Elizabeth M Hearn
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 105:8601-6. 2008
  10. ncbi Complications with remediation strategies involving the biodegradation and detoxification of recalcitrant contaminant aromatic hydrocarbons
    Max Frenzel
    Petroleum and Environmental Geochemistry Group, SoGEES, University of Plymouth, Plymouth, PL4 8AA, UK
    Sci Total Environ 408:4093-101. 2010

Detail Information

Publications234 found, 100 shown here

  1. ncbi Phenyl-modified reversed-phase liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry: a universal method for the analysis of partially oxidized aromatic hydrocarbons
    T Letzel
    Institute of Hydrochemistry, Technical University of Munich, Germany
    Anal Chem 73:1634-45. 2001
    ..stationary phase and a methanol-water solvent gradient, it allows the separation of mono- and polycyclic aromatic hydrocarbons (PAHs) having up to five condensed aromatic rings and partially oxidized derivatives within a single ..
  2. ncbi Ability of polycyclic aromatic hydrocarbons to induce 7-ethoxyresorufin-o-deethylase activity in a trout liver cell line
    N C Bols
    Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
    Ecotoxicol Environ Saf 44:118-28. 1999
    Along with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 24 unsubstituted polycyclic aromatic hydrocarbons (PAHs) were evaluated for their ability to induce 7-ethoxyresorufin-o-deethylase (EROD) activity in the rainbow trout liver cell ..
  3. ncbi Monitoring aromatic hydrocarbons by whole cell electrochemical biosensors
    Yossi Paitan
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Anal Biochem 335:175-83. 2004
    ..we describe a bacterial whole cell electrochemical biosensors system that can be used for monitoring aromatic hydrocarbons. These bacterial biosensors are based on fusions of a promoter that is sensitive to aromatic compounds (..
  4. ncbi The effect of aliphatic, naphthenic, and aromatic hydrocarbons on production of reactive oxygen species and reactive nitrogen species in rat brain synaptosome fraction: the involvement of calcium, nitric oxide synthase, mitochondria, and phospholipase A
    O Myhre
    Norwegian Defence Research Establishment, Division for Protection and Material, P.O. Box 25, N-2027, Kjeller, Norway
    Biochem Pharmacol 62:119-28. 2001
    ..In conclusion, C7 and C9 aliphatic, naphthenic, and aromatic hydrocarbons stimulated formation of ROS and RNS in rat brain synaptosomes...
  5. ncbi Application of a fiber-optic NIR-EFA sensor system for in situ monitoring of aromatic hydrocarbons in contaminated groundwater
    J Buerck
    Forschungszentrum Karlsruhe, Institut für Instrumentelle Analytik, P O Box 3640, D 76021 Karlsruhe, Germany
    J Hazard Mater 83:11-28. 2001
    ..It could be demonstrated that the fiber-optic sensor system is a valuable tool for near-real-time control of a remedial action technique and verification and documentation of its success...
  6. ncbi Evolution of occupational exposure to environmental levels of aromatic hydrocarbons in service stations
    J F Periago
    Instituto de Seguridad y Salud Laboral, c Lorca 70, 30120 El Palmar, Murcia, Spain
    Ann Occup Hyg 49:233-40. 2005
    ..A significant relationship between the volume of gasoline sold and the ambient concentration of aromatic hydrocarbons was found for each worker sampled in all three of the years...
  7. ncbi Determinants of polychlorinated aromatic hydrocarbons in serum in three age classes--Methodological implications for human biomonitoring
    Elly Den Hond
    Flemish Institute of Technological Research VITO, Environmental Toxicology, Boeretang 200, Mol 2400, Belgium
    Environ Res 109:495-502. 2009
    ..biomarkers in serum and quantify the major determinants for biomarkers of exposure to polychlorinated aromatic hydrocarbons (PCAHs) in three age groups. Data were obtained from the Flemish Environment and Health Study (2002-2006)...
  8. ncbi Functional genomics of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1
    Ralf Rabus
    Max Planck Institut für Marine Mikrobiologie, Bremen, Germany
    Appl Microbiol Biotechnol 68:580-7. 2005
    ..J Bacteriol 187:1493-1503] indicated coordinated vs sequential modes of regulation for the toluene and ethylbenzene pathways, respectively...
  9. pmc Outer-membrane transport of aromatic hydrocarbons as a first step in biodegradation
    Elizabeth M Hearn
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 105:8601-6. 2008
    ..The TodX and TbuX structures support a mechanism for transport of hydrophobic substrates from the extracellular environment to the periplasm via a channel through the hatch domain...
  10. ncbi Complications with remediation strategies involving the biodegradation and detoxification of recalcitrant contaminant aromatic hydrocarbons
    Max Frenzel
    Petroleum and Environmental Geochemistry Group, SoGEES, University of Plymouth, Plymouth, PL4 8AA, UK
    Sci Total Environ 408:4093-101. 2010
    Environmentally persistent aromatic hydrocarbons known as unresolved complex mixtures (UCMs) derived from crude oil can be accumulated by, and elicit toxicological responses in, marine organisms (e.g. mussels, Mytilus edulis)...
  11. ncbi Isolation and characterization of novel bacteria degrading polycyclic aromatic hydrocarbons from polluted Greek soils
    Haimou Zhang
    Sector of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    Appl Microbiol Biotechnol 65:124-31. 2004
    ..This is the first report of a representative of the genus Paracoccus capable of degrading PAHs with such versatility. These three strains may be useful for bioremediation applications...
  12. ncbi Exposure to MTBE, TAME and aromatic hydrocarbons during gasoline pump maintenance, repair and inspection
    Sinikka Vainiotalo
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, Helsinki, Finland
    J Occup Health 48:347-57. 2006
    ..All individual results were below corresponding biological action levels. Exposure to aromatic hydrocarbons was estimated from post-shift urine samples, with benzene showing the highest concentration (range 4...
  13. ncbi Evidence for a pore-filling mechanism in the adsorption of aromatic hydrocarbons to a natural wood char
    Thanh H Nguyen
    Department of Geography and Environmental Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Environ Sci Technol 41:1212-7. 2007
    Sorption isotherms for five aromatic hydrocarbons were obtained with a natural wood char (NC1) and its residue after solvent extraction (ENC1). Substantial isotherm nonlinearity was observed in all cases...
  14. ncbi Validation of the target lipid model for toxicity assessment of residual petroleum constituents: monocyclic and polycyclic aromatic hydrocarbons
    Joy A McGrath
    HydroQual, 1200 Macarthur Boulevard, Mahwah, New Jersey 07340, USA
    Environ Toxicol Chem 28:1130-48. 2009
    ..defensible, numeric guidelines for residual petroleum-related constituents, specifically monocyclic aromatic hydrocarbons (MAHs) and polycyclic aromatic hydrocarbons (PAHs), in the water column...
  15. ncbi Dermal exposure to jet fuel suppresses delayed-type hypersensitivity: a critical role for aromatic hydrocarbons
    Gerardo Ramos
    Department of Immunology and the Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Toxicol Sci 100:415-22. 2007
    ..The recent availability of synthetic jet fuel (S-8), which is refined from natural gas, and is devoid of aromatic hydrocarbons, made it feasible to design experiments to address this problem...
  16. ncbi Intron-dependent accumulation of mRNA in Coriolus hirsutus of lignin peroxidase gene the product of which is involved in conversion/degradation of polychlorinated aromatic hydrocarbons
    Takashi Yamazaki
    Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama
    Biosci Biotechnol Biochem 70:1293-9. 2006
    ..These results indicate that at least one intron (intron I) is required for accumulation of lip mRNA and its subsequent translational expression in C. hirsutus...
  17. ncbi Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health
    A Brouwer
    Department of Toxicology, Wageningen Agricultural University, The Netherlands
    Toxicol Ind Health 14:59-84. 1998
    ..the focus is on the multiple and interactive mechanisms of interference of persistent polyhalogenated aromatic hydrocarbons (PHAHs) and their metabolites with the thyroid hormone system...
  18. ncbi Anaerobic degradation of monoaromatic hydrocarbons
    R Chakraborty
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Appl Microbiol Biotechnol 64:437-46. 2004
    ..Many of these biochemical pathways produce unique extracellular intermediates that can be utilized as biomarkers for the monitoring of hydrocarbon degradation in anaerobic natural environments...
  19. ncbi Anaerobic biodegradation of saturated and aromatic hydrocarbons
    F Widdel
    Max Planck Institut für Marine Mikrobiologie, Celsiusstrasse 1, D 28359, Bremen, Germany
    Curr Opin Biotechnol 12:259-76. 2001
    Saturated and aromatic hydrocarbons are wide-spread in our environment. These compounds exhibit low chemical reactivity and for many decades were thought to undergo biodegradation only in the presence of free oxygen...
  20. ncbi Combined application of stable carbon isotope analysis and specific metabolites determination for assessing in situ degradation of aromatic hydrocarbons in a tar oil-contaminated aquifer
    Christian Griebler
    Environmental Mineralogy, Center for Applied Geosciences, Eberhard Karls University of Tubingen, Wilhelmstrasse 56, D 72074 Tubingen, Germany
    Environ Sci Technol 38:617-31. 2004
    ..The combined application of CSIA and SMA, as two reliable and independent tools to collect direct evidence on intrinsic bioremediation, leads to a substantially improved evaluation of natural attenuation in situ...
  21. ncbi Anaerobic biodegradation of aromatic hydrocarbons: pathways and prospects
    Julia Foght
    Biological Sciences, University of Alberta, Edmonton Alta, Canada
    J Mol Microbiol Biotechnol 15:93-120. 2008
    b>Aromatic hydrocarbons contaminate many environments worldwide, and their removal often relies on microbial bioremediation...
  22. ncbi Polycyclic aromatic hydrocarbons in the diet
    D H Phillips
    Institute of Cancer Research, Haddow Laboratories, Cotswold Road, Sutton SM2 5NG, UK
    Mutat Res 443:139-47. 1999
    Polycyclic aromatic hydrocarbons (PAHs), of which benzo[a]pyrene is the most commonly studied and measured, are formed by the incomplete combustion of organic matter...
  23. ncbi Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function
    Zongqing Tan
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Biochem Pharmacol 64:771-80. 2002
    ..These data indicate that AHR ligands elicit AHR-independent non-genomic events that are essential for AHR activation and function...
  24. pmc Role of autochthonous filamentous fungi in bioremediation of a soil historically contaminated with aromatic hydrocarbons
    A D'Annibale
    Dipartimento di Agrobiologia e Agrochimica, University of Tuscia, via S C de Lellis, 01100 Viterbo, Italy
    Appl Environ Microbiol 72:28-36. 2006
    ..fungi were tested for the abilities to grow under nonsterile conditions and to degrade various aromatic hydrocarbons in the same contaminated soil...
  25. pmc Impact of inoculation protocols, salinity, and pH on the degradation of polycyclic aromatic hydrocarbons (PAHs) and survival of PAH-degrading bacteria introduced into soil
    M Kastner
    Department of Biotechnology II, Technical University of Hamburg Harburg, Germany
    Appl Environ Microbiol 64:359-62. 1998
    Degradation of polycyclic aromatic hydrocarbons (PAHs) and survival of bacteria in soil was investigated by applying different inoculation protocols...
  26. ncbi The cytotoxicity of jet fuel aromatic hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes
    C C Chou
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Arch Toxicol 77:384-91. 2003
    Many jet fuel aromatic hydrocarbons are known carcinogens with the ability to both readily penetrate the skin with high absorptive flux and cause skin irritation...
  27. pmc Bacteria belonging to the genus cycloclasticus play a primary role in the degradation of aromatic hydrocarbons released in a marine environment
    Yuki Kasai
    Marine Biotechnology Institute, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Appl Environ Microbiol 68:5625-33. 2002
    To identify the bacteria that play a major role in the aerobic degradation of petroleum polynuclear aromatic hydrocarbons (PAHs) in a marine environment, bacteria were enriched from seawater by using 2-methylnaphthalene, phenanthrene, or ..
  28. ncbi Gene expression profiles for detecting and distinguishing potential endocrine-disrupting compounds in environmental samples
    Dong yu Wang
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3E5
    Environ Sci Technol 38:6396-406. 2004
    ..be used in gene expression profiling assays to detect androgenic effects or for the presence of bioactive aromatic hydrocarbons. Gene expression profiling is emerging as a sensitive and specific method to screen complex samples for ..
  29. ncbi The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1
    Ralf Rabus
    Max Planck Institut für Marine Mikrobiologie, Celsiusstrasse 1, 28359, Bremen, Germany
    Arch Microbiol 183:27-36. 2005
    ..Supplementary material on sequence and annotation are provided at the Web page http://www.micro-genomes.mpg.de/ebn1/...
  30. ncbi Estimation of outdoor NO(x), NO(2), and BTEX exposure in a cohort of pregnant women using land use regression modeling
    Inmaculada Aguilera
    Centre for Research in Environmental Epidemiology, Institut Municipal Investigacio Medica, Doctor Aiguader 88, 08003 Barcelona, Spain
    Environ Sci Technol 42:815-21. 2008
    ..In the INMA (Environment and Childhood) Study, ambient nitrogen oxides (NO(x) and NO(2)) and aromatic hydrocarbons (BTEX) were measured at 57 sampling sites in Sabadell (northeast Spain)...
  31. ncbi Prediction of Fenton oxidation positions in polycyclic aromatic hydrocarbons by Frontier electron density
    B D Lee
    Department of Chemical Engineering, Tokyo University of Agriculture and Technology, Koganei, Japan
    Chemosphere 42:431-5. 2001
    Five recalcitrant polycyclic aromatic hydrocarbons (PAHs) in ethanol were subjected to Fenton oxidation, and following GC-MS identification of respective oxidation products, their oxidation positions were compared to those predicted by ..
  32. ncbi Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: an explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons
    Jin Jun Chen
    Toxicology Program, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Environ Toxicol 18:115-9. 2003
    ....
  33. ncbi Phenols and aromatic hydrocarbons in chimney emissions from traditional and modern residential wood burning
    J Kjällstrand
    Department of Chemical Environmental Science, Chalmers University of Technology, 412 96 Goteborg, Sweden
    Environ Technol 22:391-5. 2001
    ..Secondary harmful components like benzene and polycyclic aromatic hydrocarbons constituted a major portion of the organic emissions...
  34. ncbi Leaching and microbial treatment of a soil contaminated by sulphide ore ashes and aromatic hydrocarbons
    Vanessa Leonardi
    Dipartimento di Agrobiologia e Agrochimica, University of Tuscia, via S C de Lellis, 01100 Viterbo, Italy
    Appl Microbiol Biotechnol 74:1135-44. 2007
    Contaminated soil from a historical industrial site and containing sulfide ore ashes and aromatic hydrocarbons underwent sequential leaching by 0.5 M citrate and microbial treatments...
  35. ncbi Metabolic diversity in aromatic compound utilization by anaerobic microbes
    Jane Gibson
    Department of Microbiology, 3 432 Bowen Science Building, The University of Iowa, Iowa City 52242, USA
    Annu Rev Microbiol 56:345-69. 2002
    ..Biochemical strategies employed by microbes to destabilize the aromatic ring in preparation for degradation have become apparent from this work...
  36. ncbi Miniaturised pressurised liquid extraction of polycyclic aromatic hydrocarbons from soil and sediment with subsequent large-volume injection-gas chromatography
    L Ramos
    Free University, Department of Analytical Chemistry and Applied Spectroscopy, Amsterdam, The Netherlands
    J Chromatogr A 891:275-86. 2000
    ..As an example, the new system was applied to the determination of polycyclic aromatic hydrocarbons (PAHs) in soils and a sediment...
  37. ncbi Detection of anaerobic metabolites of saturated and aromatic hydrocarbons in petroleum-contaminated aquifers
    Lisa M Gieg
    Department of Botany and Microbiology and Institute for Energy and the Environment, University of Oklahoma, Norman 73019, USA
    Environ Sci Technol 36:3755-62. 2002
    ..The finding of these putative anaerobic metabolites of alkanes and naphthalenes signifies the in situ biodegradation of these hydrocarbons and attests to their value as indicators of intrinsic bioremediation...
  38. ncbi Biosynthesis of medium-chain-length poly(3-hydroxyalkanoates) by volatile aromatic hydrocarbons-degrading Pseudomonas fulva TY16
    Yu Yang Ni
    Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioresour Technol 101:8485-8. 2010
    ..7%), 3-hydroxydodecenoate (8.2%), and 3-hydroxydodecanoate (6.1%). The present results suggest that P. fulva TY16 is a promising candidate for the biotechnological conversion of toxic petrochemical wastes to valuable biopolymers...
  39. ncbi Fungi growing on aromatic hydrocarbons: biotechnology's unexpected encounter with biohazard?
    Francesc X Prenafeta-Boldú
    Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands
    FEMS Microbiol Rev 30:109-30. 2006
    The biodegradation of aromatic hydrocarbons by fungi has traditionally been considered to be of a cometabolic nature...
  40. ncbi Metabolism of aromatic hydrocarbons by the filamentous fungus Cyclothyrium sp
    Manuela da Silva
    Department of Food Science, School of Food Engineering, State University of Campinas, 13083 970 Campinas, Sao Paulo, Brazil
    Chemosphere 57:943-52. 2004
    ..CBS109850. The results also show a high regioselectivity since the K-regions of phenanthrene and pyrene were the major sites of metabolism...
  41. ncbi Uptake and depuration of toxic halogenated aromatic hydrocarbons by the American oyster (Crassostrea virginica): a field study
    Piero R Gardinali
    Department of Chemistry, Southeast Environmental Research Center, Florida International University, University Park, Miami, FL 33199, USA
    Chemosphere 54:61-70. 2004
    ..With few exceptions, elimination of all toxic compounds investigated proceeded at a slower rate from the chronically exposed population that from the newly contaminated one...
  42. ncbi Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes
    Howard G Shertzer
    Department of Environmental Health, University of Cincinnati, Medical Center, 123 East Shields Street, Cincinnati, OH 45267 0056, USA
    Free Radic Biol Med 36:618-31. 2004
    ..This pathway is likely to contribute to the oxidative stress response and associated toxicity produced by many of these environmental chemicals...
  43. ncbi Analysis of polycyclic aromatic hydrocarbons in sediment reference materials by microwave-assisted extraction
    Y Y Shu
    Chemistry Department, National Kaohsiung Normal University, Taiwan, ROC
    Chemosphere 41:1709-16. 2000
    The microwave-assisted extraction (MAE) of polycyclic aromatic hydrocarbons (PAHs) from harbor sediment reference material EC-1, marine sediment reference material HS-2 and PAH-spiked river bed soil was conducted...
  44. pmc Composition of soil microbial communities enriched on a mixture of aromatic hydrocarbons
    E A Greene
    Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
    Appl Environ Microbiol 66:5282-9. 2000
    ..The enrichments effectively degraded all C5+ components except DCPD. Overall, degradation of individual C5+ hydrocarbons followed first-order kinetics, with the highest rates of removal for benzene...
  45. pmc Contrasting effects of a nonionic surfactant on the biotransformation of polycyclic aromatic hydrocarbons to cis-dihydrodiols by soil bacteria
    C C Allen
    The Questor Centre, The Queen s University of Belfast, Belfast BT9 5AG, Northern Ireland
    Appl Environ Microbiol 65:1335-9. 1999
    The biotransformation of the polycyclic aromatic hydrocarbons (PAHs) naphthalene and phenanthrene was investigated by using two dioxygenase-expressing bacteria, Pseudomonas sp...
  46. ncbi Consecutive vinylic to aryl to allylic palladium migration and multiple C-H activation processes
    Jian Zhao
    Department of Chemistry, Iowa State University, Ames, IA 50011, USA
    Angew Chem Int Ed Engl 44:1873-5. 2005
  47. ncbi Stereospecific synthesis of hetero[7]helicenes by Pd-catalyzed double N-arylation and intramolecular O-arylation
    Koji Nakano
    Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Angew Chem Int Ed Engl 44:7136-8. 2005
  48. ncbi Mild and efficient aryl-alkenyl coupling via Pd(II) catalysis in the presence of oxygen or Cu(II) oxidants
    Jay P Parrish
    Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620 5250, USA
    J Org Chem 67:7127-30. 2002
    ..The process allows reactions between various olefins and aryl stannanes of varying electron density. Coupling methods under these oxidation conditions are comparatively described, and the benefits and limitations are also discussed...
  49. ncbi Pd-catalyzed silicon hydride reductions of aromatic and aliphatic nitro groups
    Ronald J Rahaim
    Department of Chemistry, Michigan State University, East Lansing, 48824, USA
    Org Lett 7:5087-90. 2005
    ..Replacing PMHS/KF with triethylsilane allows aliphatic nitro groups to be reduced to their hydroxylamines...
  50. ncbi A facile stereocontrolled approach to CF3-substituted triarylethenes: synthesis of panomifene
    Xinyu Liu
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo ku, Kyoto 615 8510, Japan
    Angew Chem Int Ed Engl 43:879-82. 2004
  51. ncbi Palladium-catalyzed arylation of trimethylsilyl enolates of esters and imides. High functional group tolerance and stereoselective synthesis of alpha-aryl carboxylic acid derivatives
    Xiaoxiang Liu
    Department of Chemistry, Yale University, New Haven, Connecticut 06510 USA
    J Am Chem Soc 126:5182-91. 2004
    ..Mechanistic studies showed that the reaction conditions are neutral enough that the observed diastereomeric ratios reflect kinetic selectivities...
  52. ncbi Enhanced chemical oxidation of aromatic hydrocarbons in soil systems
    Namgoo Kang
    School of Civil Engineering, 550 Stadium Mall Drive, Purdue University, West Lafayette, Indiana 47907 2051, USA
    Chemosphere 61:909-22. 2005
    ..6-7.8 x 10(-4)s(-1)) were compared to the estimated rate constants (4.1-10.1 x 10(-3)s(-1)). The influence of non-specific oxidants loss (by reaction with iron hydroxides and soil organic matter) was also explored...
  53. pmc Genomic and microarray analysis of aromatics degradation in Geobacter metallireducens and comparison to a Geobacter isolate from a contaminated field site
    Jessica E Butler
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA
    BMC Genomics 8:180. 2007
    ..Geobacter metallireducens metabolizes many aromatic compounds, but the enzymes involved are not well known...
  54. ncbi Microwave-promoted Heck coupling using ultralow metal catalyst concentrations
    Riina K Arvela
    Department of Chemistry, University of Connecticut, Unit 3060, 55 North Eagleville Road, Storrs, Connecticut 06269 3060, USA
    J Org Chem 70:1786-90. 2005
    ..We show that Heck couplings can be performed in water using microwave heating and Pd catalyst concentrations as low as 500 ppb. The methodology is simple; all that is required as the catalyst is a stock solution of palladium...
  55. ncbi Fluorous-tagged carbamates for the pd-catalyzed amination of aryl halides
    Andrés A Trabanco
    Johnson and Johnson Pharmaceutical Research and Development, Research and Early Development Europe, CNS Psychiatry, Division of Janssen Cilag, Medicinal Chemistry Department, Jarama 75, 45007 Toledo, Spain
    J Org Chem 72:8146-8. 2007
    ..Preliminary results indicate that N-substituted anilines can also be obtained using just N-substituted-FBoc carbamates as the nitrogen source...
  56. ncbi Pd-catalyzed copper-free carbonylative Sonogashira reaction of aryl iodides with alkynes for the synthesis of alkynyl ketones and flavones by using water as a solvent
    Bo Liang
    Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry, School of Pharmaceutical Science, Shenzhen Graduate School, Peking University, Beijing 100871, China
    J Org Chem 70:6097-100. 2005
    ..The reaction was carried out at room temperature under balloon pressure of CO with Et(3)N as a base. The developed method was successfully applied to the synthesis of flavones...
  57. ncbi Palladium-catalyzed amination of aryl nonaflates
    Kevin W Anderson
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 68:9563-73. 2003
    ..Overall, aryl nonaflates are an effective alternative to triflates in palladium-catalyzed C-N bond-forming processes due to their increased stability under the reaction conditions...
  58. ncbi Palladium-catalyzed carbonylative annulation of o-alkynylphenols: syntheses of 2-substituted-3-aroyl-benzo[b]furans
    Youhong Hu
    Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 5731, USA
    J Org Chem 67:2365-8. 2002
    ..Consistent with this mechanism, addition of 1 equiv of AgBF(4) to palladium catalyst Pd(Ph(3)P)(4) generates an ideal candidate for this unique transformation...
  59. ncbi First comprehensive investigation of Suzuki couplings of alkenyl nonaflates with aryl and alkenyl boronic acid derivatives by using classical conditions and microwave heating
    Jens Högermeier
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustrasse 3, 14195 Berlin, Germany
    Chemistry 13:2410-20. 2007
    ..2.1]octene derivatives, such as 15, by the stereoselective conversion of this compound into highly substituted furanose 31 or substituted pyran derivative 33, which were obtained in short and efficient reaction sequences...
  60. ncbi Oil spill in the Rio de la Plata estuary, Argentina: 1. Biogeochemical assessment of waters, sediments, soils and biota
    J C Colombo
    Laboratorio de Química Ambiental y Biogeoquímica, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, Av Calchaqui km 23500 1888 Florencio Varela, Buenos Aires, Argentina
    Environ Pollut 134:277-89. 2005
    ..The following paper present the results of the study of the progress of hydrocarbon disappearance in sediments and soils 13 and 42 months after the spill...
  61. ncbi Simple amine/Pd(OAc)(2)-catalyzed suzuki coupling reactions of aryl bromides under mild aerobic conditions
    Bin Tao
    Department of Chemistry, MSC 8L0378, Georgia State University, 33 Gilmer Street, SE Unit 8, Atlanta, Georgia 30303 3088, USA
    J Org Chem 69:4330-5. 2004
    ..Another catalytic system employing DAPCy in EtOH provides a general and convenient method to prepare biaryls from aryl bromides and boronic acids with a broad range of functional groups at room temperature and under aerobic conditions...
  62. ncbi Palladium-catalyzed cross-coupling reactions of diazine N-oxides with aryl chlorides, bromides, and iodides
    Jean Philippe Leclerc
    Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N6N5, Canada
    Angew Chem Int Ed Engl 45:7781-6. 2006
  63. ncbi Suzuki-Miyaura coupling catalyzed by polymer-incarcerated palladium, a highly active, recoverable, and reusable Pd catalyst
    Kuniaki Okamoto
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Org Lett 6:1987-90. 2004
    ..Various coupling reactions proceeded smoothly using PI Pd with phosphine ligands, and the catalyst could be recovered by simple filtration and reused several times without loss of activity...
  64. ncbi Oxidations of hydrocarbons by manganese(III) tris(hexafluoroacetylacetonate)
    Jasmine R Bryant
    Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195 1700, USA
    Inorg Chem 41:2769-76. 2002
    ..The ability of Mn(hfacac)(3) to abstract H* is reasonable given its high redox potential and the basicity of [Mn(hfacac)(3)](-). In CH(2)Cl(2) solution, oxidation of DHA is catalyzed by chloride ion...
  65. ncbi Preparation and palladium-catalyzed cross-coupling of aryl triethylammonium bis(catechol) silicates with aryl triflates
    W Michael Seganish
    Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA
    J Org Chem 69:1137-43. 2004
    ..The cross-coupling reaction is tolerant of a wide range of electron-donating and electron-withdrawing groups. Several examples of di-ortho-substituted triflates are successfully coupled with these reagents...
  66. ncbi Nickel-on-charcoal-catalyzed aromatic aminations and Kumada couplings: mechanistic and synthetic aspects
    Stefan Tasler
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 9510, USA
    J Org Chem 68:1190-9. 2003
    ..Larger scale reactions of both types of couplings have been successfully performed, suggesting that Ni/C-based processes can be scaled-up as needed...
  67. ncbi Selected patented cross-coupling reaction technologies
    Jean Pierre Corbet
    Rhodia Recherches, Centre de Recherches et de Technologies de Lyon, 85 rue des frères Perret, BP 62, 69192 Saint Fons cedex, France
    Chem Rev 106:2651-710. 2006
  68. ncbi A new class of substituted aryl bis(oxazoline) ligands for highly enantioselective copper-catalyzed asymmetric aldol addition of dienolsilane to pyruvate and glyoxylate esters
    Julie Cong Dung Le
    The Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
    Org Lett 6:4097-9. 2004
    ..Enantioselectivities up to 98% ee (before recrystallization) and isolated yields up to 91% were observed. Additionally, chloride counterions were found to be superior to triflate for this reaction...
  69. ncbi Room-temperature Kumada cross-coupling of unactivated aryl chlorides catalyzed by N-heterocylic carbene-based nickel(II) complexes
    Zhenxing Xi
    Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou, PR China
    J Org Chem 73:3954-7. 2008
    ..The catalysts are so active that the reactions proceed at room temperature in excellent yields...
  70. ncbi Highly enantioselective and regioselective biocatalytic azidolysis of aromatic epoxides
    J H Spelberg
    Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, and Department of Organic and Molecular Inorganic Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Org Lett 3:41-3. 2001
    ..In a large scale conversion, the decrease in yield and selectivity due to the uncatalyzed chemical side reaction could be overcome by slow addition of azide...
  71. ncbi Rhodium-catalyzed arylative and alkenylative cyclization of 1,5-enynes induced by geminal carbometalation of alkynes
    Yiyun Chen
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    J Am Chem Soc 128:15598-9. 2006
    ..This vinyl rhodium then adds to the pendent alkene, and the protodemetalation of the resulting rhodium enolate affords the product...
  72. ncbi Asymmetric hydrogenation of alpha-chloro aromatic ketones catalyzed by eta6-arene/TsDPEN-ruthenium(II) complexes
    Takeshi Ohkuma
    Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060 8628, Japan
    Org Lett 9:255-7. 2007
    ..The hydrogenation of an alpha-chloro ketone with a phenol moiety has been utilized for the synthesis of (R)-norphenylephrine without protection-deprotection operations. [reaction: see text]...
  73. ncbi Efficient iron/copper co-catalyzed arylation of nitrogen nucleophiles
    Marc Taillefer
    CNRS, UMR 5076, Architectures Moléculaires et Matériaux Nanostructurés, Ecole Nationale Superieure de Chimie de Montpellier, 8, rue de l Ecole Normale, 34296 Montpellier Cedex 5, France
    Angew Chem Int Ed Engl 46:934-6. 2007
  74. pmc Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles
    Denis V Gribkov
    Department of Chemistry, Columbia University, New York, New York 10027, USA
    J Am Chem Soc 129:11750-5. 2007
    ....
  75. ncbi The catalytic cross-coupling of unactivated arenes
    David R Stuart
    Center for Catalysis Research and Innovation, University of Ottawa, Department of Chemistry, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5
    Science 316:1172-5. 2007
    ..This efficient reactivity should be useful in the design of other oxidative arene cross-couplings as well...
  76. ncbi Benzene: a secondary pollutant formed in the three-way catalyst
    Stefan Bruehlmann
    Laboratory of Organic Chemistry, Swiss Federal Laboratories for Materials Testing and Research Empa, Uberlandstrasse 129, 8600 Dubendorf, Switzerland
    Environ Sci Technol 39:331-8. 2005
    ..83-0.95, with a pronounced minimum at 0.87, was observed. Dealkylation reactions of aromatic hydrocarbons are assumed to be the major pathway leading to benzene.
  77. ncbi Combinatorial Knoevenagel reactions
    Sergey V Ryabukhin
    Enamine Ltd, 23 A Matrosova st, 01103 Kyiv, Ukraine
    J Comb Chem 9:1073-8. 2007
    ..High yields and a simple workup of target compounds enables the facile generation of combinatorial libraries comprising 11,000 compounds of high structural and functional diversity...
  78. ncbi Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4]triazine: synthesis of an alpha 2/3-selective GABA agonist
    Donald R Gauthier
    Department of Process Research, Merck Research Laboratories, Merck and Co Inc, P O Box 2000, Rahway, NJ 07065, USA
    J Org Chem 70:5938-45. 2005
    ..A highly regioselective palladium-catalyzed arylation in the final step highlights the efficiency of the route...
  79. ncbi Synthesis, structure, and conformation of aza[1n]metacyclophanes
    Matthew Vale
    Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588 0304, USA
    J Org Chem 73:27-35. 2008
    ....
  80. ncbi An improved catalyst for the asymmetric arylation of ketone enolates
    Takayuki Hamada
    Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
    J Am Chem Soc 124:1261-8. 2002
    ..The coupling of alpha-alkyl-alpha'-protected cyclopentanones proceeded in high yield, and the resulting quaternary stereogenic center was installed in up to 94% ee...
  81. pmc Enantioselective alpha-arylation of ketones with aryl triflates catalyzed by difluorphos complexes of palladium and nickel
    Xuebin Liao
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Am Chem Soc 130:195-200. 2008
    ....
  82. ncbi Palladium-catalyzed coupling reactions of aryl chlorides
    Adam F Littke
    Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Room 18 411, Cambridge 02139 4307, USA
    Angew Chem Int Ed Engl 41:4176-211. 2002
    ..This review summarizes both the seminal early work and the exciting recent developments in the area of palladium-catalyzed couplings of aryl chlorides...
  83. ncbi Enantioselective, palladium-catalyzed alpha-arylation of N-Boc-pyrrolidine
    Kevin R Campos
    Department of Process Research, Merck Research Laboratories, P O Box 2000, Rahway, New Jersey 07065, USA
    J Am Chem Soc 128:3538-9. 2006
    ....
  84. pmc Selective partial reduction of various heteroaromatic compounds with bridgehead nitrogen via Birch reduction protocol
    Joseph T Kim
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 7061, USA
    J Org Chem 70:2054-9. 2005
    ..Finally, it was shown that various fused diazines were smoothly and stereoselectively reduced under Birch reduction conditions to give trans-4,5-disubstituted dihydropyrimidines 30 and 32 in virtually quantitative yields...
  85. ncbi An enantioselective organocatalytic oxidative dearomatization strategy
    Ngoc T Vo
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW
    J Am Chem Soc 130:404-5. 2008
  86. ncbi Enantioselective synthesis of bicyclo[6.1.0]nonane-9-carboxylic acids via Me2AlOTf-promoted intramolecular Friedel-Crafts alkylation of arenes with the gamma-lactone moiety of 3-oxabicyclo[3.1.0]hexan-2-ones
    Eric Fillion
    Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    J Org Chem 68:9485-8. 2003
    ..The scope and limitations of this synthetic methodology are presented...
  87. ncbi Liquid chromatographic properties of aromatic sulfur heterocycles on a Pd(II)-containing stationary phase for petroleum analysis
    Kishore Sripada
    Institute of Inorganic and Analytical Chemistry, NRW International Graduate School of Chemistry, University of Munster, Corrensstrasse 30, 48149 Muenster, Germany
    Anal Bioanal Chem 382:735-41. 2005
    ..with other aromatic systems are weakly retained and elute in a first fraction with the polycyclic aromatic hydrocarbons. Thiophene rings condensed with other aromatic rings are more strongly retained and elute in a later ..
  88. ncbi Solvent-free iodination of organic molecules using the I(2)/urea-H(2)O(2) reagent system
    Jasminka Pavlinac
    Laboratory for Organic and Bioorganic Chemistry, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Org Biomol Chem 5:699-707. 2007
    ..Moreover, addition of iodine to 1-octene and some phenylacetylenic derivatives was found to proceed efficiently without the presence of any oxidizer and solvent at room temperature...
  89. ncbi A facile and clean direct cyanation of heteroaromatic compounds using a recyclable hypervalent iodine(III) reagent
    Toshifumi Dohi
    Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Chem Pharm Bull (Tokyo) 54:1608-10. 2006
    ..The facile and clean direct cyanating reaction of pyrroles and thiophenes has been achieved using a recyclable hypervalent iodine(III) reagent 1b by a simple solid-liquid separation of the products and the reagent...
  90. pmc Anaerobic degradation of benzene, toluene, ethylbenzene, and o-xylene in sediment-free iron-reducing enrichment cultures
    Michael K Jahn
    Lehrstuhl Umweltmineralogie, Zentrum für Angewandte Geowissenschaften, Eberhard Karls Universitat Tubingen, Germany
    Appl Environ Microbiol 71:3355-8. 2005
    ..The electron balances showed a complete anaerobic oxidation of the aromatic compounds to CO2. This is the first report on the anaerobic degradation of o-xylene and ethylbenzene in sediment-free iron-reducing enrichment cultures...
  91. ncbi Fingerprinting petroleum hydrocarbons in plankton and surface sediments during the spring and early summer blooms in the Galician coast (NW Spain) after the Prestige oil spill
    N Salas
    Department of Environmental Chemistry, CID CSIC, Jordi Girona Salgado, 18 26, 08034 Barcelona, Spain
    Mar Environ Res 62:388-413. 2006
    ..at three transects along the Galician coast (NW Spain) were analysed for individual aliphatic and aromatic hydrocarbons by GC-MS...
  92. ncbi A shallow BTEX and MTBE contaminated aquifer supports a diverse microbial community
    K P Feris
    Land, Air, and Water Resources, The University of California, Davis, Davis, CA 95616, USA
    Microb Ecol 48:589-600. 2004
    ..Further study is required to determine whether these changes have an impact on the functioning of this subsurface ecosystem...
  93. ncbi Biomarkers of PAH exposure in an intertidal fish species from Prince William Sound, Alaska: 2004-2005
    Robert J Huggett
    White Water Associates, Amasa, Michigan 49903, USA
    Environ Sci Technol 40:6513-7. 2006
    ..The similar low EROD activity and bile FAC concentrations in fish from oiled and unoiled shores, supports the hypothesis that these low-level biomarker responses were not caused by exposure of the fish to residues of the spilled oil...
  94. ncbi Protocol for laboratory testing of crude-oil bioremediation products in freshwater conditions
    J R Haines
    National Risk Management Research Laboratory, US Environmental Protection Agency, 26 Martin Luther King Drive, Cincinnati, OH 45268, USA
    J Ind Microbiol Biotechnol 30:107-13. 2003
    ..Differences in product performance were easily distinguishable using the protocol, and performance targets for alkane and aromatic hydrocarbon degradation are suggested...
  95. ncbi Laboratory evaluation of oil spill bioremediation products in salt and freshwater systems
    John R Haines
    United States Environmental Protection Agency, Cincinnati, OH 45268, USA
    J Ind Microbiol Biotechnol 32:171-85. 2005
    ..degrees of biodegradative activity against the alkane fraction of the crude oil and three degraded the aromatic hydrocarbons by >10%...
  96. ncbi Non-aromatic hydrocarbons in surface sediments near the Pearl River estuary in the South China Sea
    Xuelu Gao
    Key Laboratory of Tropical Marine Environmental Dynamics, South China Sea Institute of Oceanology, CAS, Guangzhou, China
    Environ Pollut 148:40-7. 2007
    ..for total organic carbon (TOC), total nitrogen (TN), solvent extractable organic matter (EOM) and non-aromatic hydrocarbons. TOC, TN and EOM show distinct spatial variations...
  97. ncbi Screening of halogenated aromatic compounds in some raw material lots for an aluminium recycling plant
    Seija Sinkkonen
    Department of Chemistry, University of Jyvaskyla, PO Box 35, FIN 40351 Jyvaskyla, Finland
    Environ Int 30:363-6. 2004
    ..The concentrations of PCBs, PCNs (polychlorinated naphthalenes) and nona- to undecachlorinated terphenyls in some of these scrap samples were remarkably high...
  98. ncbi Fluorescence excitation-emission matrix regional integration to quantify spectra for dissolved organic matter
    Wen Chen
    PBS4J INC 7310 N 16th St Ste 310, Phoenix, AZ 85020, USA
    Environ Sci Technol 37:5701-10. 2003
    ..Aromatic carbon and the presence of specific aromatic compounds (as indicated by solid-state 13C NMR and FTIR data) resulted in EEMs that aided in differentiating wastewater effluent DOM from drinking water DOM...
  99. ncbi Signature metabolites attesting to the in situ attenuation of alkylbenzenes in anaerobic environments
    M S Elshahed
    Department of Botany and Microbiology, University of Oklahoma, Norman, Oklahoma 73019, USA
    Environ Sci Technol 35:682-9. 2001
    ..Our studies confirm the utility of the aforementioned compounds as signature metabolites attesting to the natural attenuation of aromatic hydrocarbons in anaerobic environments.
  100. ncbi Photochemical acetalization of carbonyl compounds in protic media using an in situ generated photocatalyst
    H J Peter de Lijser
    Department of Chemistry and Biochemistry, California State University Fullerton, Fullerton, California 92834 6866, USA
    J Org Chem 69:8315-22. 2004
    ..The acetalization process is initiated by ionization of TCHQ, followed by loss of a proton to the solvent or the carbonyl, which starts a catalytic reaction. The photocatalyst is regenerated via a disproportionation reaction...
  101. ncbi Facile access to polysubstituted indoles via a cascade Cu-catalyzed arylation-condensation process
    Yu Chen
    Department of Chemistry, Fudan University, Shanghai, China
    J Org Chem 72:9329-34. 2007
    ..Polysubstituted indoles can be prepared from substituted 2-halotrifluoroacetanilides with high regioselectivity...

Research Grants69

  1. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..The primary scientific aims are: (1) to assess the independent role of polycyclic aromatic hydrocarbons (PAH), 1,3-butadiene, acrolein, benzene, and ethylene oxide in the development of lung cancer among ..
  2. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ....
  3. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..carbon, nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), aldehydes, and polycyclic aromatic hydrocarbons (PAHs) will be sampled from the mine...
  4. MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITY
    Alvaro Puga; Fiscal Year: 2013
    ..Frequently, these mixtures include a combination of carcinogenic metals and polycyclic aromatic hydrocarbons (PAH)...
  5. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..Chronic exposures to air particulates and chemicals associated with particulate matter, such as polycyclic aromatic hydrocarbons, have been associated with development or exacerbation of atherosclerosis in rodents and primates...
  6. Exposure and biological response biomarkers of cigarette smoke
    IAN ALEXANDER BLAIR; Fiscal Year: 2010
    ..smoke is an extremely complex mixture, which some 3800 constituents including numerous polycyclic aromatic hydrocarbons (PAHs), in both the mainstream and sidestream (environmental) smoke fractions...
  7. The role of human DNA polymerase eta in the mutagenic response to oxidative stres
    SCOTT DAVID MCCULLOCH; Fiscal Year: 2013
    ..provided by applicant): Oxidative stress is caused by a number of environmental agents such as polycyclic aromatic hydrocarbons like dioxin, heavy metals, pesticides, and ultraviolet and ionizing radiation...
  8. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..of particular concern for altered age of onset and progression of male puberty include chlorinated aromatic hydrocarbons, a family of highly toxic environmental contaminants that includes polychlorinated dibenzo-p- dioxins, ..
  9. Cancer induction in the ovary by an environmental pollutant, dibenzo[a,l]pyrene
    Kun Ming Chen; Fiscal Year: 2013
    ..Diol-epoxides derived from polycyclic aromatic hydrocarbons (PAH) can covalently bind to DNA of ovarian cells from human exposed to cigarette smoke...
  10. Modulation of Neonatal Hyperoxic Lung Injury by the Aryl Hydrocarbon Receptor
    Binoy Shivanna; Fiscal Year: 2013
    ..roles of cytochrome P450 1A enzymes in hyperoxic lung injury, and the regulation of AhR by the polycyclic aromatic hydrocarbons. In addition to Dr. Moorthy, my advisory committee consists of Drs...
  11. Case-Cohort Study of Cancers in Excess in Poultry Workers
    Eric S Johnson; Fiscal Year: 2013
    ..Safety and Health Research program), but also to other occupational carcinogens, including polycyclic aromatic hydrocarbons, heterocyclic amines, nitrosamines, benzene, etc...
  12. PHAHs and Thyroid Cancer Risk in DoDSR Cohort
    Yawei Zhang; Fiscal Year: 2013
    ..Emerging evidence indicates that polybrominated diphenyl ethers (PBDEs) and other polyhalogenated aromatic hydrocarbons (PHAHs), including polychlorinated biphenyls (PCBs) and organochlorine pesticides, are able to alter ..
  13. Diagnostic Utility of mtDNA Content and Exercise Challenge in Veterans with GWI
    MICHAEL JOSEPH FALVO; Fiscal Year: 2013
    ..DNA (mtDNA) damage is positively associated with exposure to particulate matter, benzene, and polycyclic aromatic hydrocarbons in humans...
  14. Aldo-Keto Reductases and PAH Metabolism/Activation
    Trevor M Penning; Fiscal Year: 2013
    ..AKRs activate tobacco polycyclic aromatic hydrocarbons (PAH) to yield reactive and redox-active PAH o-quinones...
  15. P53-dependent responses to toxicants in parous and nulliparous breast
    D Joseph Jerry; Fiscal Year: 2010
    ..comes from mouse models showing that exposures such as ionizing radiation (IR) and polycyclic aromatic hydrocarbons (PAHs) increase mammary tumor formation...
  16. Childhood Leukemia and Home Environmental Exposures
    Patricia A Buffler; Fiscal Year: 2010
    ..and indoor air, including pesticides, persistent organic compounds (polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and nicotine, a surrogate for tobacco smoke), and volatile organic compounds...
  17. TOXICOLOGICAL SIGNIFICANCE OF ALKYLBENZENE METABOLISM
    Wayne L Backes; Fiscal Year: 2013
    ..Alkylbenzenes are produced in extensive quantities throughout the world, with simple aromatic hydrocarbons being major components of gasoline and used in a wide variety of consumer products...
  18. A Miniaturized GC with MEMS-Enabled Selective Preconcentration for Monitoring Exp
    Masoud Agah; Fiscal Year: 2013
    ..to enable the identification of key compounds in three classes of HAPs: aromatic solvents;polycyclic aromatic hydrocarbons, and non-aromatic hydrocarbons...
  19. Body Burden of PAHs and Cardiovascular Disease in the United States
    JOHN DAVIS CLARK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Polycyclic aromatic hydrocarbons (PAHs) are environmental and occupational carcinogens that are produced by the incomplete combustion of organic material, such as that from tobacco, coal, and ..
  20. Mutagenesis of p53 by reactive PAH and ROS
    JEFFREY M FIELD; Fiscal Year: 2012
    Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental air pollutants that result from fossil fuel combustion and cigarette smoking. PAH exposure is a major risk factor in human lung carcinogenesis...
  21. Biomarkers of toxic response to low nicotine cigarette smoke
    Andrew Strasser; Fiscal Year: 2012
    ..Cigarette smoke is an extremely complex mixture including numerous toxic polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-..
  22. Understanding aromatic hydrocarbon uptake as the first step in biodegradation
    Bert van den Berg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aromatic hydrocarbons (AH) are widespread pollutants within the environment owing to natural, industrial and social activities...
  23. AHR signaling in Mammalian and Non-Mammalian Models
    Mark E Hahn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polynuclear aromatic hydrocarbons are ubiquitous environmental contaminants with adverse effects on human health...
  24. Molecular mechanism of cytochrome P4501A1 expression.
    Bhagavatula Moorthy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polycyclic aromatic hydrocarbons (PAHs) are present in cigarette smoke, particulate matter, and in charcoal broiled meats...
  25. Prophylactic Use of Vitamin E for Prevention of Occupational PAH-Induced Damage
    Debbie Mustacich; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Polycyclic aromatic hydrocarbons (PAHs), including benzo(a)pyrene (BP), form a major class of environmental pollutants suggested to be causative factors in a variety of disease susceptibilities, ..
  26. HOW ENVIRONMENTAL CHEMICALS IMPAIR IMMUNITY
    David Sherr; Fiscal Year: 2009
    ..While many studies demonstrate that environmentally ubiquitous polycyclic aromatic hydrocarbons (PAH) suppress the mature immune system, relatively few have evaluated their effects on the developing ..
  27. Pathway Modeling of Complex Toxin Response and Energy Balance Systems in Cancer
    Nora L Nock; Fiscal Year: 2012
    ..Toxins such as polycyclic aromatic hydrocarbons (PAHs), which are ubiquitous and can create direct (PAH-DNA adduct) and indirect oxidative (8-oxo-dG) DNA ..
  28. Modulation of PAH ovarian toxicity by biotransformation enzyme polymorphisms
    Ulrike Luderer; Fiscal Year: 2010
    ..Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants, which are known to impair ovarian function and cause ..
  29. The role of heterocyclic aromatic amines in breast cancer
    Robert J Turesky; Fiscal Year: 2010
    ..to environmental and dietary pollutants such as pesticides, polychlorinated biphenyls or polycyclic aromatic hydrocarbons and breast cancer...
  30. Excision of Carcinogen-DNA Adducts in Nucleosomes
    Nicholas E Geacintov; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polycyclic aromatic hydrocarbons (PAH) are byproducts of fossil fuel combustion and are present in our air, food and water;the presence of these genotoxic environmental carcinogens in our environment ..
  31. Exposure to mobile source air pollution and adverse birth outcomes in the Los Ang
    Jun Wu; Fiscal Year: 2009
    ..Outdoor concentrations of polycyclic aromatic hydrocarbons (PAH), nitric oxide (NO), and nitrogen dioxide (NO2) at each residence will be estimated and summarized by ..
  32. Early Life Exposures to Air Toxics and the Risk of Early Childhood Leukemia
    Elaine Symanski; Fiscal Year: 2013
    ..using modeled estimates of census-tract ambient air levels of benzene, 1,3-butadiene and polycyclic aromatic hydrocarbons (PAHs) from the U.S. EPA's National-Scale Air Toxics Assessment...
  33. Role of calcium and reactive oxygen species in toxicant-induced immune failure
    Mohamed Trebak; Fiscal Year: 2009
    ..In polycyclic aromatic hydrocarbons (PAH)-induced lymphocyte immune suppression, enhanced ROS production is associated with increased basal ..
  34. Impact of proximal promoter polymorphisms on AHR gene expression in human lung
    David C Spink; Fiscal Year: 2013
    ..been recognized as an integral component of the carcinogenic process initiated by smoke-born polycyclic aromatic hydrocarbons and other carcinogens that result from incomplete combustion...
  35. PAH Exposure and DNA Damage in Roofers
    Berrin Serdar; Fiscal Year: 2011
    ..Exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) has been a major concern in this industry, mainly in workers exposed to asphalt fumes and coal tar...
  36. Ah Receptor Dysregulation Alters Hematopoietic Stem Cells
    Thomas A Gasiewicz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human exposures to polycyclic aromatic hydrocarbons and dioxins have been linked to the development of lymphomas and leukemias...
  37. The Nashville Breast Health Study
    Wei Zheng; Fiscal Year: 2009
    ..charred) meat intake, and thus exposures to the mammary carcinogens heterocyclic amines and polycyclic aromatic hydrocarbons, may be related to an increased risk of breast cancer, particularly among women with certain genotypes of ..
  38. ANALYSIS OF AH RECEPTOR LIGAND BINDING SPECIFICITY
    Michael Steven Denison; Fiscal Year: 2013
    ..the toxic and biological effects of a variety of exogenous chemicals, such as the toxic halogenated aromatic hydrocarbons (HAHs) and polycyclic aromatic hydrocarbons (PAHs), and these effects appear to result from AhR-dependent ..
  39. Developmental Gene-Environment Interactions and Premature Ovarian Failure
    Ulrike Luderer; Fiscal Year: 2013
    ..death of ovarian follicles caused by withdrawal of gonadotropins or by chemical toxicants, like polycyclic aromatic hydrocarbons (PAHs), and that supplementation of the major antioxidant glutathione (GSH) is protective...
  40. Polycyclic Aromatic Hydrocarbons And Male Reproductive Health
    HUEIWANG ANNA COOK JENG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Polycyclic Aromatic Hydrocarbons and Male Reproductive Health Despite heightened concerns over reported declines in sperm quality;a lack of epidemiologic data exists regarding a link to job-related ..
  41. ARYL AND ALCOHOL SULFOTRANSFERASES IN DRUG METABOLISM
    Michael W Duffel; Fiscal Year: 2010
    ..molecules from xenobiotics that include benzylic alcohols derived from alkyl-substituted polycyclic aromatic hydrocarbons, hydroxylamine metabolites of aromatic amines and nitroaromatics, and allylic alcohols...
  42. Carcinogen-DNA Adducts: Topology, Conformation and Repair (Renewal)
    Suse Broyde; Fiscal Year: 2013
    A category of non-planar, twisted polycyclic aromatic hydrocarbons (PAHs), termed fjord region compounds, are extremely potent tumorigens;they include dibenzo[a,l]pyrene which has recently been cited as the most tumorigenic PAH yet ..
  43. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen S Hecht; Fiscal Year: 2013
    ..types of carcinogens believed to play a significant role in lung cancer development in smokers: polycyclic aromatic hydrocarbons (PAH) and tobacco-specific nitrosamines, typified by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)...
  44. Phenotyping/Epigenetic studies of PAH-associated Treg impairment in asthma
    Kari C Nadeau; Fiscal Year: 2013
    ..and asthma outcomes by studying immune system changes in subjects exposed to elevated levels of polycyclic aromatic hydrocarbons (PAH)...
  45. Prenatal Exposures & Procarcinogenic Mutations
    Manuela Orjuela; Fiscal Year: 2007
    ..in New York City, who are subject to varying levels of environmental exposures including polycyclic aromatic hydrocarbons (PAH) and organophosphate pesticides such as chlorpyrifos...
  46. Exposure To Polycyclic Aromatic Hydrocarbons And Male Sperm Quality
    HUEIWANG ANNA COOK JENG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Exposure to Polycyclic Aromatic Hydrocarbons and Male Sperm Quality Polycyclic aromatic hydrocarbons (PAHs) are one of the most ubiquitous environmental pollutants...
  47. Neurobehavioral and Neuroimaging Effects of Traffic Exposure in Children
    Patrick H Ryan; Fiscal Year: 2013
    ..evidence suggests that TRAP, a complex mixture of metals, elemental and organic carbon, polycyclic aromatic hydrocarbons, and fine and ultrafine particulate matter, is capable of inducing neuroinflammation and translocation ..
  48. Target Organ DNA Damage in Coke Oven Workers
    Glenn Talaska; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Making accurate exposure measurements for polycyclic aromatic hydrocarbons remains one of the most vexing problems facing the occupational health professional...
  49. Convergence of MicroRNAs and p53 Signaling in Multiple Myeloma: Environmental Co
    Yong Li; Fiscal Year: 2013
    ..It constitutes about 1% of human cancers and 2% of all cancer deaths. Polycylic aromatic hydrocarbons such as 2,3,7,8- tetrachlorodibenzo--dioxin (TCDD) have been closely correlated to MM by epidemiologic ..
  50. Biological Response Indicators of Environment Stress Centers
    STEPHEN MORRIS RAPPAPORT; Fiscal Year: 2011
    ..It will validate the biosensors by measuring blood protein adducts of polycyclic aromatic hydrocarbons in the blood from asphalt and construction workers...
  51. Synergistic Immunosuppression by PAHs and Arsenite
    SCOTT WILLIAM BURCHIEL; Fiscal Year: 2013
    ..the mechanisms of immunosuppression in mice and humans associated with combined exposures to polycyclic aromatic hydrocarbons (PAHs) and sodium arsenite (As+3)...
  52. REALTIME waterpipe tobacco smoke toxicant sampling in the natural environment
    Alan Shihadeh; Fiscal Year: 2013
    ..in particular for: particle number, particle mass, nicotine, tobacco-specific nitrosamines, and polycyclic aromatic hydrocarbons. 2) Evaluate REALTIME design options in the clinical laboratory (Years 1 and 2)...
  53. The Role of Mitochondrial DNA Damage in Neurodegeneration
    JOEL NEWMAN MEYER; Fiscal Year: 2013
    ..for handling mitochondrial DNA damage caused by important environmental genotoxins such as polycyclic aromatic hydrocarbons and ultraviolet radiation...
  54. Transcriptional regulation of polycyclic aromatic hydrocarbon metabolism
    Jeffrey M Peters; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polycyclic aromatic hydrocarbons (PAH) are a class of environmental chemicals that are known to cause toxicity and cancers in humans...
  55. The Aryl Hydrocarbon Receptor and Breast Cancer
    Sakina E Eltom; Fiscal Year: 2013
    ..ligand- activated transcription factor which mediates the carcinogenic effects of environmental polycyclic aromatic hydrocarbons (PAH)...
  56. Field Deployable Vapor Intrusion Monitor
    Bikas Vaidya; Fiscal Year: 2011
    ..outside of a building to monitor volatile and semi-volatile toxic chemicals such as: TCE, PCE, polycyclic aromatic hydrocarbons and polybrominated diphenyls...
  57. Molecular and Physiological Responses to Persistent Mitochondrial DNA Damage
    JOEL NEWMAN MEYER; Fiscal Year: 2010
    ..fate of mtDNA damaged by environmental genotoxins, such as ultraviolet C radiation (UVC) and polycyclic aromatic hydrocarbons, is also poorly understood...
  58. Transgenic Models of Ah Receptor Action
    Christopher A Bradfield; Fiscal Year: 2013
    ..AHR) is a ligand-activated transcription factor that mediates the biological effects of polycyclic aromatic hydrocarbons (PAHs), halogenated-dioxins ("dioxins"), - dibenzofurans, -biphenyls (PCBs), and -diphenylethers...
  59. NITROAROMATICS AND BREAST CANCER
    KARAM E EL-BAYOUMY; Fiscal Year: 2011
    ..Widespread environmental agents (e.g., nitropolycyclic aromatic hydrocarbons [NO2-PAH]) that are known to induce mammary cancer in rodents must be regarded as potential human ..
  60. Rapid response human testing of smokeless tobacco products
    Pamela I Clark; Fiscal Year: 2013
    ..one-time use of a tobacco product, including salivary tobacco-specific nitrosamines (TSNAs) and polycyclic aromatic hydrocarbons (PAHs) and exhaled breath volatile organic compounds (VOCs), all measured before and after single-use of ..
  61. LSU Superfund Research Center - Environmentally Persistent Free Radicals
    Barry Dellinger; Fiscal Year: 2013
    ..Our researchers have discovered chlorinated aromatic hydrocarbons and substituted phenols chemisorb to the surfaces of particulate matter containing redoxactive transition ..
  62. Windows of Susceptibility to PAH/DEP Exposure and Asthma
    Rachel L Miller; Fiscal Year: 2011
    ..Ventures in Environmental Research (DISCOVER) seeks to understand when and how airborne polycyclic aromatic hydrocarbons (PAHs) and diesel exhaust particles(DEP) increase the risk for childhood asthma and airway inflammation, ..
  63. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
    ..g., CYP1A1, CYP1A2 and CYP2E1) whose activity is induced by polycyclic aromatic hydrocarbons in tobacco smoke...
  64. DIOXINS AND HYPOTHALAMIC APPETITE NEUROPEPTIDES
    GEORGE GREELEY; Fiscal Year: 2000
    ..primary hypothesis for this small grant is that developmental exposure (ie, perinatal) to PolyChlorinated Aromatic Hydrocarbons (PCAHs) or to mixtures of PCAHs disrupts the central control of feeding behavior...
  65. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ..Oral carcinogens derived from these exposures include N-nitrosamines, polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic amines, and acetaldehyde that are activated and detoxified by enzyme ..
  66. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..include environmentally important heterocyclic amines, nitrosamines, aflatoxins, nitrated polycyclic aromatic hydrocarbons, and arylamines such as 4-aminobiphenyl (ABP)...
  67. MODIFIERS OF CARCINOGENESIS--ENVIRONMENTAL PAH MIXTURES
    William Baird; Fiscal Year: 2005
    Humans are exposed to polycyclic aromatic hydrocarbons (PAH) in complex environmental mixtures and this exposure is linked to human cancer...
  68. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ..in infants and young children from prenatal exposure to environmental air pollutants, including polycyclic aromatic hydrocarbons (PAH), particulate matter (PM2.5), and environmental tobacco smoke (ETS)...
  69. PAH/Metal exposure and effects assessment in Chattanooga
    Sean Richards; Fiscal Year: 2004
    ..As a result of the dumping and deposition, polycyclic aromatic hydrocarbons (PAH) and heavy metals have permeated South Chattanooga soil...