allyl compounds

Summary

Top Publications

  1. ncbi Different activation patterns of rat xenobiotic metabolism genes by two constituents of garlic
    Ping Zhang
    Laboratoire de Nutrition et de Sécurité Alimentaire, INRA Domaine de Vilvert, 78352 Jouy en Josas, France
    Carcinogenesis 27:2090-5. 2006
  2. ncbi Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells
    Surajit Karmakar
    Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 323K, PO Box 250606, Charleston, SC 29425, USA
    Apoptosis 12:671-84. 2007
  3. ncbi Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells
    Arabinda Das
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Cancer 110:1083-95. 2007
  4. ncbi Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Oncogene 24:6256-68. 2005
  5. ncbi Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo
    Kuang Chi Lai
    Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan
    Phytomedicine 19:625-30. 2012
  6. ncbi Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-α, and CYP2E1
    Tao Zeng
    Institute of Toxicology, School of Public Health, Shandong University, 44 Wenhua West Road, Shandong, Jinan 250012, PR China
    Food Chem Toxicol 50:485-91. 2012
  7. pmc In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
    Hanaa A Hassan
    Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt
    Int J Biol Sci 5:249-55. 2009
  8. ncbi Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1
    Hye Kyung Na
    Department of Food and Nutrition, College of Human Ecology, Sungshin Women s University, Seoul, South Korea
    Biochem Pharmacol 84:1241-50. 2012
  9. ncbi Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?
    H Nissbrandt
    Department of Pharmacology, Institute of Physiology and Pharmacology, Goteborg University, Goteborg, Sweden
    Synapse 40:294-301. 2001
  10. pmc Apoptosis induction of U937 human leukemia cells by diallyl trisulfide induces through generation of reactive oxygen species
    Yung Hyun Choi
    Department of Biochemistry, Dongeui University College of Oriental Medicine, San 45, Yangjung dong Busanjin gu, Busan 614 052, Republic of Korea
    J Biomed Sci 19:50. 2012

Detail Information

Publications213 found, 100 shown here

  1. ncbi Different activation patterns of rat xenobiotic metabolism genes by two constituents of garlic
    Ping Zhang
    Laboratoire de Nutrition et de Sécurité Alimentaire, INRA Domaine de Vilvert, 78352 Jouy en Josas, France
    Carcinogenesis 27:2090-5. 2006
    ..Because constitutively activated receptor (CAR) is a major transcription factor driving the xenobiotic-induced stimulation of CYP2B1/2 through NR1, the role of CAR as a preferential mediator of DAS effect is discussed...
  2. ncbi Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells
    Surajit Karmakar
    Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 323K, PO Box 250606, Charleston, SC 29425, USA
    Apoptosis 12:671-84. 2007
    ..Results strongly suggested that the garlic compounds DAS and DADS suppressed anti-apoptotic factors and activated calpain and intrinsic caspase cascade for apoptosis in SH-SY5Y cells...
  3. ncbi Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells
    Arabinda Das
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Cancer 110:1083-95. 2007
    ..Garlic-derived organosulfur compounds such as diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) provide significant protection against carcinogenesis...
  4. ncbi Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Oncogene 24:6256-68. 2005
    ..In conclusion, the results of the present study indicate that DATS-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by ROS-mediated destruction and hyperphosphorylation of Cdc 25 C...
  5. ncbi Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo
    Kuang Chi Lai
    Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan
    Phytomedicine 19:625-30. 2012
    ..05) in the colo 205 xenograft mice. Based on our in vitro and in vivo results, diallyl polysulfides (DAS, DADS and DATS) affected the gene expression of the multidrug resistance in colo 205 human colon cancer cells in vitro and in vivo...
  6. ncbi Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-α, and CYP2E1
    Tao Zeng
    Institute of Toxicology, School of Public Health, Shandong University, 44 Wenhua West Road, Shandong, Jinan 250012, PR China
    Food Chem Toxicol 50:485-91. 2012
    ..These results suggested that GO had the potential to ameliorate alcoholic steatosis which might be related to its modulation on SREBP-1c, PPAR-α, and CYP2E1...
  7. pmc In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
    Hanaa A Hassan
    Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt
    Int J Biol Sci 5:249-55. 2009
    ..However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a phytoantioxidant with powerful chemopreventive properties against chemically-induced oxidative stress...
  8. ncbi Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1
    Hye Kyung Na
    Department of Food and Nutrition, College of Human Ecology, Sungshin Women s University, Seoul, South Korea
    Biochem Pharmacol 84:1241-50. 2012
    ..These results suggest that DATS-induced apoptosis is mediated through ROS generation and subsequent activation of JNK and AP-1...
  9. ncbi Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?
    H Nissbrandt
    Department of Pharmacology, Institute of Physiology and Pharmacology, Goteborg University, Goteborg, Sweden
    Synapse 40:294-301. 2001
    ..Other mechanisms, such as the influence on the DA transporter or the release process cannot, however, be ruled out...
  10. pmc Apoptosis induction of U937 human leukemia cells by diallyl trisulfide induces through generation of reactive oxygen species
    Yung Hyun Choi
    Department of Biochemistry, Dongeui University College of Oriental Medicine, San 45, Yangjung dong Busanjin gu, Busan 614 052, Republic of Korea
    J Biomed Sci 19:50. 2012
    ..However, the mechanisms of antiproliferative activity in leukemia cells are not fully understood. In this study, the apoptotic effects of DATS were investigated in human leukemia cells...
  11. ncbi DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kappaB activation in RAW 264.7 macrophages
    Kai Li Liu
    Department of Nutrition, Chung Shan Medical University, Taichung 40203, Taiwan, ROC
    J Agric Food Chem 54:3472-8. 2006
    ..The inhibitory effect of DATS on LPS-induced iNOS expression is likely attributed to its antioxidant potential to inhibit NF-kappaB activation...
  12. ncbi Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells
    C C Wu
    Department of Nutrition and Health Science, Fooyin University, Kaohsiung 831, Taiwan, ROC
    Food Chem Toxicol 42:1937-47. 2004
    ....
  13. ncbi Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo
    Ping Ping Wu
    School of Pharmacy, China Medical University, Taichung, Taiwan
    Phytomedicine 18:672-6. 2011
    ..These findings indicated that DATS inhibits tumor growth in an allograft animal model. Thus, DATS may represent a colon cancer preventive agent and can be used in the future...
  14. pmc Protective effects of garlic oil on hepatocarcinoma induced by N-nitrosodiethylamine in rats
    Cui Li Zhang
    Institute of Toxicology, School of Public Health, Shandong University, Jinan, PR China
    Int J Biol Sci 8:363-74. 2012
    ..These data suggest that GO exhibited significant protection against NDEA-induced hepatocarcinogenesis, which might be related with the enhancement of the antioxidant activity and the induction of apoptosis...
  15. ncbi Inhibition of matrix metalloproteinase activities and tightening of tight junctions by diallyl disulfide in AGS human gastric carcinoma cells
    Hyun Soo Park
    Dept of Pharmacy, Pusan Natl Univ, Busan 609 735, Republic of Korea
    J Food Sci 76:T105-11. 2011
    ..Although further studies are needed, these results suggest that DADS treatment may inhibit tumor cell motility and invasion and, therefore, act as a dietary source to decrease the risk of cancer metastasis...
  16. ncbi Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals
    Chi Chen
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Free Radic Biol Med 37:1578-90. 2004
    ....
  17. ncbi The modulatory effects of garlic oil on hepatic cytochrome P450s in mice
    Tao Zeng
    Institute of Toxicology, Shandong University, Shandong, Jinan 250012, P R China
    Hum Exp Toxicol 28:777-83. 2009
    ..The CYP2E1 and 1A2 suppression might contribute to its hepatoprotection, and data about CYP3A indicated that GO was unlikely to alter the metabolism of the concomitantly used drugs...
  18. ncbi Protective effects of diallyl sulfide on N-nitrosodimethylamine-induced immunosuppression in mice
    H G Jeong
    Department of Biological Science, Chosun University, Kwangju, South Korea
    Cancer Lett 134:73-9. 1998
    ..The results show that the protective effects of DAS against the NDMA-induced immunotoxicity may, at least in part, be due to its ability to block bioactivation of NDMA mainly by the inhibition of cytochrome P450 2E1...
  19. ncbi Effect of Allium sativum (garlic) diallyl disulfide (DADS) on human non-small cell lung carcinoma H1299 cells
    C Hui
    School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226007, P R China
    Trop Biomed 25:37-45. 2008
    ..These results indicated that diallyl disulfide could induce apoptosis in human non-small cell lung carcinoma H1299 cells via, at least partly, G2/M-phase block of the cell cycle, related to a rise in MAPK phosphorylation...
  20. ncbi Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells
    Kang Beom Kwon
    Department of Physiology, School of Oriental Medicine, Wonkwang University, 570 749, Iksan, Republic of Korea
    Biochem Pharmacol 63:41-7. 2002
    ..The induction of apoptosis by DADS may be the pivotal mechanism by which its chemopreventative action against cancer is based...
  21. pmc Role of Bim in diallyl trisulfide-induced cytotoxicity in human cancer cells
    Byeong Chel Lee
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Cell Biochem 112:118-27. 2011
    ..Our results indicate that the cytotoxicity caused by DATS is mediated by the generation of ROS and subsequent activation of the ASK1-JNK-Bim signal transduction pathway in human breast carcinoma MDA-MB-231 cells...
  22. ncbi Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 12:6836-43. 2006
    ..The present study was undertaken to determine the effect of garlic constituent diallyl trisulfide (DATS) on growth of PC-3 human prostate cancer xenograft in vivo...
  23. ncbi Modulation of p53 in 7,12-dimethylbenz[a]anthracene-induced skin tumors by diallyl sulfide in Swiss albino mice
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Center, PO Box 80, MG Marg, Lucknow 226001, India
    Mol Cancer Ther 3:1459-66. 2004
    ..Thus, DAS can be a potential chemopreventive agent against skin tumor development...
  24. ncbi Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3
    Chantey R Morris
    Eppley Institute for Research in Cancer, Omaha, Nebraska 68198, USA
    Nutr Cancer 48:54-63. 2004
    ..7-70 microM for inhibition by DADS. With PEITC, Ki for MPN depentylation by REM, rat CYP2E1, and rat CYP2A3 was 0.4-4.6 microM. These low Ki and IC50 values may help explain how garlic and Cruciferae inhibit carcinogenesis...
  25. ncbi Garlic oil prevents tributyltin-induced oxidative damage in vivo and in vitro
    Hui Gang Liu
    Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou 310031, China
    J Food Prot 70:716-21. 2007
    ..The possible protective mechanism may stem from the considerable ability of GO to scavenge ROS. We conclude that GO could be an effective agent or food supplement in reducing the toxicity of TBT...
  26. ncbi Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells
    Danhua Xiao
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Mol Cancer Ther 4:1388-98. 2005
    ..These findings may be useful in the identification, synthesis, and development of organosulfur compounds that have anticancer activity...
  27. ncbi Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide
    Giuseppe Filomeni
    Department of Biomedical Sciences, University of Chieti G D Annunzio via dei Vestini, 66013 Chieti, Italy
    Cancer Res 63:5940-9. 2003
    ....
  28. ncbi Preclinical perspectives on garlic and cancer
    John A Milner
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD 20854, USA
    J Nutr 136:827S-831S. 2006
    ..Likewise, additional studies are needed that incorporate transgenic and knockout models to assist in the identification of molecular targets for garlic and its associated allyl sulfur components...
  29. ncbi Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo
    Wenjun Li
    Department of Thoracic Surgery, Qilu Hospital, Shandong University, Jinan, China
    Acta Biochim Biophys Sin (Shanghai) 44:577-83. 2012
    ..All the evidence both in vitro and in vivo suggested that DATS could be an ideal anti-cancer drug...
  30. ncbi Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells
    C C Wu
    Department of Food Science, National Chung Hsing University, Taichung, Taiwan
    Food Chem Toxicol 39:563-9. 2001
    The modulation of garlic oil (GO) and three allyl compounds, diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS), on the antioxidation system in rat livers and red blood cells was examined...
  31. ncbi Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin
    Takashi Hosono
    Department of Applied Life Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa 252 8510, Japan
    J Biol Chem 280:41487-93. 2005
    ..1 Da. The potent antitumor activity of DATS was also demonstrated in nude mice bearing HCT-15 xenografts. This is the first paper describing intracellular target molecules directly modified by garlic components...
  32. ncbi Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1beta
    H S Lee
    Department of Pathology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC
    Osteoarthritis Cartilage 17:91-9. 2009
    ..Investigation of the effects of diallyl sulfide (DAS), a garlic sulfur compound, on joint tissue inflammatory responses induced by monosodium urate (MSU) crystals and interleukin-1beta (IL-1beta)...
  33. pmc Diallyl trisulfide-induced apoptosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest
    Dong Xiao
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Carcinog 48:1018-29. 2009
    ....
  34. ncbi Involvement of multiple signaling pathways in diallyl sulfide mediated apoptosis in mouse skin tumors
    Neetu Kalra
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow 226001, India
    Asian Pac J Cancer Prev 7:556-62. 2006
    ....
  35. ncbi Diallyl disulfide increases CDKN1A promoter-associated histone acetylation in human colon tumor cell lines
    Nathalie Druesne-Pecollo
    Laboratoire de Nutrition et Securite Alimentaire, INRA, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France
    J Agric Food Chem 54:7503-7. 2006
    ....
  36. ncbi Diallyl trisulfide inhibits angiogenic features of human umbilical vein endothelial cells by causing Akt inactivation and down-regulation of VEGF and VEGF-R2
    Dong Xiao
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nutr Cancer 55:94-107. 2006
    ..The present study demonstrates, for the first time, that DATS has the ability to inhibit angiogenic features of human endothelial cells...
  37. ncbi P66Shc mediated ferritin degradation--a novel mechanism of ROS formation
    Andzelika Borkowska
    Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, Debinki 1, 80 211 Gdansk, Poland Poland
    Free Radic Biol Med 51:658-63. 2011
    ..DATS induced G2/M arrest in WT MEFs but had no effect in the p66Shc(-/-) cell line. Moreover, increases in LIP and ROS formation were significantly attenuated in p66Shc(-/-) MEFs treated with DATS...
  38. ncbi Allitridi inhibits transient outward potassium currents in human atrial myocytes
    Chun yu Deng
    Department of Cardiology, Guangdong Cardiovascular Institute and Guangdong Academy of Medical Sciences, Research Centre of Guangdong General Hospital, Guangzhou, China
    Clin Exp Pharmacol Physiol 38:323-7. 2011
    ..4. The results of the present study indicate that allitridi inhibits I(to), but not I(Kur) and I(Ca), and prolongs the action potential duration in human atrial myocytes...
  39. ncbi Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells
    Yun Bin Wang
    Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou 310003, Zhejiang Province, China
    Phytomedicine 17:363-8. 2010
    ..These findings suggest that DATS may be an effective way for treating human bladder and other types of cancers...
  40. ncbi Oxidative stress potentiated by diallylsulfide, a selective CYP2E1 inhibitor, in isoniazid toxic effect on rat primary hepatocytes
    Qing Zhai
    Department of Pharmacy, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China
    Toxicol Lett 183:95-8. 2008
    ..In conclusion, DAS could potentiate INH toxic effect and this is the first study reporting the effect of DAS on oxidative stress in INH-induced hepatocytotoxicity...
  41. ncbi Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Cancer Lett 242:28-36. 2006
    ..Thus, one mechanism of the growth inhibitory properties of DAS is through the suppression of development of tumors that harbor ras mutations by inhibiting the membrane association of oncogenic p21/ras protein...
  42. ncbi Role of garlic in the prevention of ischemia-reperfusion injury
    Goksel Sener
    Marmara University School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Mol Nutr Food Res 51:1345-52. 2007
    ..Future studies should focus on post ischemia reperfusion administration of garlic to explore its rescue potential rather than prophylactic impact. Bench research findings should be translated into clinical use through human studies...
  43. ncbi Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice
    Tao Zeng
    Institute of Toxicology, Shandong University, 44 Wenhua West Road, Shandong, Jinan 250012, PR China
    Toxicology 252:86-91. 2008
    ..The increase of the hepatic and mitochondrial GSH levels and the elevation of the antioxidant enzymes activities should account for the preventive effects...
  44. ncbi Anticancer effects of diallyl trisulfide derived from garlic
    Taiichiro Seki
    Laboratory of Nutrition and Physiology, Department of Applied Life Sciences, Nihon University Graduate School of Bioresource Sciences, Kameino 1866, Fujisawa, Kanagawa 252 8510, Japan
    Asia Pac J Clin Nutr 17:249-52. 2008
    ..These results suggest that diallyl trisulfide is responsible, at least in part, for the epidemiologically proven anticancer effect for garlic eaters...
  45. ncbi Allitridi induces apoptosis by affecting Bcl-2 expression and caspase-3 activity in human gastric cancer cells
    Hong Lan
    Beijing Molecular Oncology, Beijing Institute for Cancer Research, School of Oncology, Peking University, Beijing 100034, China
    Acta Pharmacol Sin 25:219-25. 2004
    ..To investigate the mechanism of allitridi-induced apoptosis in human gastric cancer cell line BGC823...
  46. ncbi In vivo metabolism of diallyl disulphide in the rat: identification of two new metabolites
    E Germain
    Unité Mixte de Recherche de Toxicologie Alimentaire, Institut National de Recherche Agronomique, BP 86510, 17 rue Sully, F 21065 Dijon Cedex, France
    Xenobiotica 32:1127-38. 2002
    ..Only AMSO and AMSO(2) are significantly excreted in urine. 4. These potential metabolites are thought to be active in the target tissues. Our data warrant further studies to check this hypothesis...
  47. ncbi Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow 226 001, India
    Nutr Cancer 44:89-94. 2002
    ..These observations suggest that induction of apoptosis may be the major contributing factor for antitumorigenic properties of DAS...
  48. pmc Diallyl trisulfide-induced G2/M phase cell cycle arrest in DU145 cells is associated with delayed nuclear translocation of cyclin-dependent kinase 1
    Anna Herman-Antosiewicz
    Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Pharm Res 27:1072-9. 2010
    ..The present study was undertaken to gain insight into the molecular mechanism of G2/M phase cell cycle arrest resulting from treatment of DU145 cells with diallyl trisulfide (DATS), a promising cancer chemopreventive constituent of garlic...
  49. ncbi Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2
    Dong Xiao
    Department of Pharmacology and Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Oncogene 23:5594-606. 2004
    ..In conclusion, our data point towards important roles for Bcl-2, JNK and ERK in DATS-induced apoptosis in human prostate cancer cells...
  50. ncbi Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling
    Sangeeta Shrotriya
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
    Cancer Res 70:1932-40. 2010
    ..Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis...
  51. pmc Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide
    Marie Lue Antony
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Indian J Exp Biol 49:805-16. 2011
    ..This article reviews mechanisms and targets of cancer chemoprevention by DATS...
  52. ncbi The antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infection
    Shuang Liu
    Department of Microbiology and Key Laboratory for Experimental Teratology of Chinese Ministry of Education, School of Medicine, Shandong University, Jinan, Shandong, China
    FEMS Microbiol Lett 303:183-9. 2010
    ..Our investigations on the antibacterial mode of action of allitridi provide an insight into the potential use of allitridi as a therapeutic agent against H. pylori infection...
  53. ncbi Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells
    Ahmed Malki
    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
    Cancer Biol Ther 8:2175-85. 2009
    ..Together, the results of the present study show, for the first time, that DATS administration might offer a novel strategy for the treatment of human breast cancer...
  54. ncbi Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways
    Jai Sing Yang
    Department of Pharmacology, China Medical University, Taichung 404, Taiwan
    Food Chem Toxicol 47:171-9. 2009
    ..The COLO 205 cells were pre-treated with JNK inhibitor before leading to decrease the percentage of apoptosis which was induced by DADS. Inhibition of caspase-3 activation blocked DADS-induced apoptosis on COLO 205 cells...
  55. pmc Investigating antibacterial effects of garlic (Allium sativum) concentrate and garlic-derived organosulfur compounds on Campylobacter jejuni by using Fourier transform infrared spectroscopy, Raman spectroscopy, and electron microscopy
    Xiaonan Lu
    School of Food Science, Washington State University, Pullman, WA 99163, USA
    Appl Environ Microbiol 77:5257-69. 2011
    ....
  56. ncbi Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats
    Cheng Tzu Liu
    Department of Nutrition, Chung Shan Medical University, No 110, Sec 1, Chien Kuo N Road, Taichung 402, Taiwan, Republic of China
    Eur J Pharmacol 516:165-73. 2005
    ..Both garlic oil and diallyl trisulfide improve glycemic control in diabetic rats through increased insulin secretion and increased insulin sensitivity...
  57. pmc Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds
    Anna A Powolny
    Department of Pharmacology and Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cancer Lett 269:305-14. 2008
    ..This article summarizes preclinical and limited clinical data to warrant further clinical evaluation of Allium vegetable constituents for prevention and therapy of human cancers...
  58. ncbi Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2
    Craig D Fisher
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Drug Metab Dispos 35:995-1000. 2007
    ..These studies indicate that GO constituents, particularly DAS, activate CAR and Nrf2 to induce drug-metabolizing enzymes...
  59. ncbi Solid-phase microextraction-gas chromatographic-mass spectrometric analysis of garlic oil obtained by hydrodistillation
    O Calvo-Gómez
    Unidad de Biotecnología e Ingeniería Genética de Plantas, Centro de Investigacion y de Estudios Avanzados del IPN, Km 9 6 Libramiento Norte, Carretera Irapuato León, 36500 Irapuato, Guanajuato, Mexico
    J Chromatogr A 1036:91-3. 2004
    ..Among the 47 totally identified compounds, 18 were linear sulfur-containing volatile compounds, 6 were of non-sulfur nature, and the other 23 were cyclic compounds. However, linear sulfur volatiles accounted for 94% of the total amount...
  60. ncbi Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis
    Hsiao Chi Wang
    Graduate Institute of Food Science and Technology, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei 106, Taiwan
    J Agric Food Chem 58:7096-103. 2010
    ..DATS also displayed selective target of growth inhibition between skin cancer cells and normal keratinocyte HaCaT cells. Taken together, these results suggest that DATS is a potential anticancer compound for skin cancer...
  61. pmc Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak
    Young Ae Kim
    Department of Pharmacology and Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Mol Cancer Ther 6:1599-609. 2007
    ..In conclusion, the present study reveals that the mitochondria-mediated cell death by DATS is associated with ROS generation and regulated by Bax/Bak but independent of Bcl-2 or Bcl-xL...
  62. ncbi Preventive effects of diallyl sulfide on 7,12-dimethylbenz[a]anthracene induced DNA alkylation damage in mouse skin
    Nidhi Nigam
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
    Mol Nutr Food Res 51:1324-8. 2007
    ..49% protection, at an intermittent period of 48 h, against DMBA-induced DNA strand breakage. These findings suggest that DAS can effectively check the mutations induced by environmental toxicants...
  63. ncbi Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines
    Y S Hong
    Department of Biochemistry, Medical Research Center, College of Medicine, Ewha Womans University, Seoul, Korea
    Exp Mol Med 32:127-34. 2000
    ....
  64. ncbi Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by Allium vegetable-derived organosulfur compounds: a review
    Anna Herman-Antosiewicz
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Suite 2 32A Hillman Cancer Center Research Pavilion, 5117 Center Avenue, Pittsburgh, PA 15213, USA
    Mutat Res 555:121-31. 2004
    ..This review summarizes current knowledge on signal transduction pathways leading to perturbations in cell cycle progression and apoptosis induction by OSCs...
  65. ncbi Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction
    D Guyonnet
    Institut National de la Recherche Agronomique, , BP 86510, 17 rue Sully, 21065 Dijon Cedex, France
    Mutat Res 495:135-45. 2001
    ..This study demonstrated that the antimutagenic activities of OSCs against several ultimate carcinogens were closely related to their ability to induce phase II enzymes...
  66. ncbi Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines
    H Nakagawa
    Department of Pathology II and Department of Surgery II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan
    Carcinogenesis 22:891-7. 2001
    ..Thus, DADS could be a promising anticancer agent for both hormone-dependent and -independent breast cancers, and may harmonize with polyunsaturated fatty acids known as modulators of breast cancer cell growth...
  67. ncbi Mechanisms of protection against aflatoxin B(1) genotoxicity in rats treated by organosulfur compounds from garlic
    Denis Guyonnet
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche de Toxicologie Alimentaire, BP 86510, 17 rue Sully, 21065 Dijon Cedex, France
    Carcinogenesis 23:1335-41. 2002
    ..The induction of rGSTA5 and rAFAR1 is probably the main mechanism by which allyl sulfides give protection against AFB(1)-induced carcinogenesis...
  68. ncbi The role of reactive oxygen species (ROS) production on diallyl disulfide (DADS) induced apoptosis and cell cycle arrest in human A549 lung carcinoma cells
    Xin Jiang Wu
    Institute of Indoor and Environmental Toxicology, Faculty of Medicine, Justus Liebig University of Giessen, Aulweg 123, D 35385 Giessen, Germany
    Mutat Res 579:115-24. 2005
    ..Treatment of A549 cells with N-acetyl cysteine (NAC) completely abrogated DADS-induced cell cycle arrest and apoptosis. The result indicated that oxidative stress modulates cell proliferation and cell death induced by DADS...
  69. ncbi Diallyl disulfide (DADS) increases histone acetylation and p21(waf1/cip1) expression in human colon tumor cell lines
    Nathalie Druesne
    Laboratoire de Nutrition et Securite Alimentaire, INRA, Jouy en Josas, France
    Carcinogenesis 25:1227-36. 2004
    ..The present study provides evidence for cellular and molecular responses triggered by DADS that could be linked to its effect on histone acetylation and play a role in its protective properties on colon carcinogenesis...
  70. ncbi Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats
    José Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico
    Mol Cell Biochem 254:125-30. 2003
    ..The mechanism by which DAS has a protective effect on GM-induced nephrotoxicity may be related, at least in part, to the decrease in oxidative stress in renal cortex...
  71. ncbi Effects of diallyl disulfide (DADS) on expression of apoptosis associated proteins in androgen independent human prostate cancer cells (PC-3)
    Ramachandran Gayathri
    Department of Endocrinology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu 600 113, India
    Mol Cell Biochem 320:197-203. 2009
    ..Bcl-2 protein has significantly decreased in DADS treated cells. Therefore, the present investigation serves as evidence that DADS may be a therapeutic drug in the treatment of prostate cancer...
  72. ncbi Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells
    H F Lu
    Department of Clinical Pathology, Cheng Hsin Rehabilitation Medical Center, Taipei 100, Taiwan, ROC
    Food Chem Toxicol 42:1543-52. 2004
    ..DADS also increased cyclin E and decreased CDK2 gene expression which may lead to the G2/M arrest of T24 cells...
  73. ncbi Role of Ca(2+) in diallyl disulfide-induced apoptotic cell death of HCT-15 cells
    Eun Kyung Park
    Department of Biochemistry and Institute of Oral Bioscience, Dental School, Chonbuk National University, Chonju, Chonbuk 561 756, Korea
    Exp Mol Med 34:250-7. 2002
    ..Collectively, our data demonstrate that DADS can induce apoptosis in HCT-15 cells through the sequential mechanism of Ca(2+) homeostasis disruption, accumulation of H(2)O(2), and resulting caspase-3 activation...
  74. ncbi c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells
    Jedrzej Antosiewicz
    Department of Pharmacology and Urology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 66:5379-86. 2006
    ..In conclusion, the present study provides experimental evidence to indicate existence of a novel pathway involving JNK signaling axis in regulation of DATS-induced ROS generation...
  75. ncbi Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Carcinogenesis 27:533-40. 2006
    ..In conclusion, the present study demonstrates that DATS-induced apoptosis in human prostate cancer cells is mediated, at least in part, by inactivation of Akt signaling axis...
  76. ncbi Effect of garlic (Allium sativum) on lipid peroxidation in experimental myocardial infarction in rats
    G Saravanan
    Postgraduate Department of Biochemistry, Bharathidasan College of Arts and Science, Ellispet, Erode 638116, India
    J Ethnopharmacol 94:155-8. 2004
    ..In conclusion, garlic oil exerts its effects by modulating lipid peroxidation and enhancing antioxidant and detoxifying enzyme systems...
  77. ncbi Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis
    Jaw Ming Cherng
    Department of Internal Medicine, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan, ROC
    Photodermatol Photoimmunol Photomed 27:138-46. 2011
    ..Diallyl sulfide (DAS) has been shown to have a preventive effect against various cancers...
  78. ncbi Enhancement of diallyl disulfide-induced apoptosis by inhibitors of MAPKs in human HepG2 hepatoma cells
    Jun Wen
    Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China
    Biochem Pharmacol 68:323-31. 2004
    ....
  79. ncbi Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: implications for cancer prevention
    Mukesh Kumar Agarwal
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    Food Chem Toxicol 45:1634-40. 2007
    ....
  80. pmc Total synthesis of enantiopure (+)-gamma-lycorane using highly efficient Pd-catalyzed asymmetric allylic alkylation
    Bruno D Chapsal
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 8:1395-8. 2006
    ....
  81. pmc Palladium-catalyzed asymmetric allylic alkylation of meso- and dl-1,2-divinylethylene carbonate
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 128:3931-3. 2006
    ..The absolute and relative configurations of iso-cladospolide B and 11-epi-iso-cladospolide B were verified by total synthesis, solving an apparent discrepancy in the literature...
  82. ncbi Pd-catalyzed asymmetric allylic alkylation. A short route to the cyclopentyl core of viridenomycin
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 5:1563-5. 2003
    ..reaction: see text]..
  83. ncbi Enantiomerically pure nucleophiles in diastereoselective palladium catalysed allylic substitution reactions
    Mark E Humphries
    Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom
    Chirality 15:190-5. 2003
    ..e.) using achiral ligands on symmetrical allylic acetates. Nucleophilic substitution of amino esters with enantiomerically pure ligands enabled diastereoselective ratios of 95:5 to be obtained...
  84. pmc Ligand controlled highly regio- and enantioselective synthesis of alpha-acyloxyketones by palladium-catalyzed allylic alkylation of 1,2-enediol carbonates
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 130:11852-3. 2008
    ..Besides the commonly used protection groups such as OAc and OPiv, a more functionalized group such as methyl but-2-enoyl group can also be used, downstream process of which can afford other synthetically interesting structures...
  85. ncbi Catalytic conjugate addition of allyl groups to styryl-activated enones
    Joshua D Sieber
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Am Chem Soc 129:2214-5. 2007
  86. ncbi Diallyl disulfide and diallyl trisulfide up-regulate the expression of the pi class of glutathione S-transferase via an AP-1-dependent pathway
    Chia Wen Tsai
    Department of Nutrition and School of Dentistry, Chung Shan Medical University, No 110 Sec 1 Chien Kuo N Road, Taichung 40203, Taiwan
    J Agric Food Chem 55:1019-26. 2007
    ..Our results indicate that the effectiveness of DADS and DATS on GSTP expression is likely related to the JNK-AP-1 and ERK-AP-1 signaling pathways and, thus, that DADS and DATS enhance the binding of AP-1 to GPE I...
  87. doi Catalytic asymmetric conjugate addition and allylic alkylation with Grignard reagents
    Syuzanna R Harutyunyan
    Organic Chemistry Laboratories, Stratingh Institute for Chemistry, Faculty of Mathematics and Natural Sciences, University of Groningen, Nijenborgh 4, Groningen 9747 AG, The Netherlands
    Chem Rev 108:2824-52. 2008
  88. ncbi Two diallyl sulphides derived from garlic inhibit meticillin-resistant Staphylococcus aureus infection in diabetic mice
    Shih Ming Tsao
    Department of Infection, Chung Shan Medical University Hospital, Taichung City, Taiwan, Republic of China
    J Med Microbiol 56:803-8. 2007
    ..05), and these levels were significantly decreased by treatment with DAS or DADS (P<0.05). These data suggest that DAS and DADS could provide multiple protective functions against MRSA infection in diabetic mice...
  89. ncbi The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum)
    Stephen R Davis
    Mycology Unit, Women s and Children s Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia
    J Antimicrob Chemother 51:593-7. 2003
    ..The results demonstrate that both garlic derivatives and raw garlic extract appear to have in vitro activity against S. prolificans...
  90. doi Gold-catalyzed allyl-allyl coupling
    Susana Porcel
    Institute of Chemical Research of Catalonia ICIQ, Av Paisos Catalans 16, 43007 Tarragona, Spain
    Angew Chem Int Ed Engl 47:1883-6. 2008
  91. ncbi Do garlic-derived allyl sulfides scavenge peroxyl radicals?
    Riccardo Amorati
    Dipartimento di Chimica Organica A Mangini, Bologna University, Via San Giacomo 11, 40126 Bologna, Italia
    Org Biomol Chem 6:1103-7. 2008
    ..It is therefore concluded that sulfides 1 and 3 do not scavenge peroxyl radicals and therefore cannot be considered chain-breaking antioxidants...
  92. ncbi Pd asymmetric allylic alkylation (AAA). A powerful synthetic tool
    Barry M Trost
    Department of Chemistry, Stanford University, CA 94305 5080, USA
    Chem Pharm Bull (Tokyo) 50:1-14. 2002
    ....
  93. ncbi A convergent Pd-catalyzed asymmetric allylic alkylation of dl- and meso-divinylethylene carbonate: enantioselective synthesis of (+)-australine hydrochloride and formal synthesis of isoaltholactone
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Chemistry 13:9547-60. 2007
    ..A mechanism for this intriguing transformation is proposed and a concise enantioselective total synthesis of (+)-australine hydrochloride is reported as well as a formal synthesis of isoaltholactone...
  94. ncbi Modular phosphite-oxazoline/oxazine ligand library for asymmetric pd-catalyzed allylic substitution reactions: scope and limitations-origin of enantioselectivity
    Montserrat Diéguez
    Departament de Quimica Fisica i Inorganica, Universitat Rovira i Virgili Campus Sescelades, C Marcel li Domingo, s n 43007 Tarragona, Spain
    Chemistry 14:3653-69. 2008
    ..It also indicates that the nucleophilic attack takes place predominantly at the allylic terminal carbon atom located trans to the phosphite moiety...
  95. pmc Catalytic asymmetric synthesis of allylic thiol derivatives
    Larry E Overman
    Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697 2025, USA
    Org Lett 10:1485-8. 2008
    ....
  96. ncbi Geminal dicarboxylates as carbonyl surrogates for asymmetric synthesis. Part II. Scope and applications
    B M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    J Am Chem Soc 123:3687-96. 2001
    ..In conjunction with the subsequent reactions that occur with high stereospecificity, allylic gem-dicarboxylates serve as synthons for a double allylic transformation...
  97. pmc Palladium-catalyzed beta-allylation of 2,3-disubstituted indoles
    Natsuko Kagawa
    Department of Chemistry, University of Chicago, Chicago, IL 60637, USA
    Org Lett 10:2381-4. 2008
    ..Described is a general, high-yielding method for the palladium-catalyzed beta-allylation of carba- and heterocycle fused indoles, including complex natural product substrates...
  98. ncbi Selective effects of diallyl disulfide, a sulfane sulfur precursor, in the liver and Ehrlich ascites tumor cells
    Małgorzata Iciek
    Chair of Medical Biochemistry, Collegium Medicum, Jagiellonian University, Kopernika 7, PL 31 034 Kraków, Poland
    Eur J Pharmacol 569:1-7. 2007
    ..These data indicate that this compound is capable of acting efficiently and selectively only in the liver and can be used for hepatoprotection during chemotherapy...
  99. ncbi Geminal dicarboxylates as carbonyl surrogates for asymmetric synthesis. Part I. Asymmetric addition of malonate nucleophiles
    B M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 123:3671-86. 2001
    ..The process constitutes the equivalent of an addition of a stabilized nucleophile to a carbonyl group with high asymmetric induction...
  100. pmc syn-1,2-Amino alcohols via diastereoselective allylic C-H amination
    Kenneth J Fraunhoffer
    Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA
    J Am Chem Soc 129:7274-6. 2007
  101. ncbi Synthesis of chiral chromans by the Pd-catalyzed asymmetric allylic alkylation (AAA): scope, mechanism, and applications
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 126:11966-83. 2004
    ....

Research Grants53

  1. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  2. INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 2006
    ..The selective synthesis of contiguous stereotriads will advance basic methodology for asymmetric conjugate additions. ..
  3. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
    ..Daphnicyclidin A. This recent discovery has revealed a new molecular architecture which exhibits significant antitumor activity. Our research will investigate strategies for chemical synthesis of these complex polycyclic systems. ..
  4. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  5. New Methods for the Synthesis of Neurological Agents
    LARRY OVERMAN; Fiscal Year: 2008
    ..oryzae at 90 nM, suggesting potential antitumor activity. Because of the scarcity of these natural products from their natural sources, little biological evaluation has been carried out. ..
  6. Asymmetric Reaction Technologies for the Synthesis of Chemotherapeutic Agents
    Scott Nelson; Fiscal Year: 2007
    ..Furthermore, efforts to develop catalytic asymmetric variants of these cycloadditions are intended to maximize the utility of these reactions in industrial medicinal and process chemical research. ..
  7. Identifying the Antiplatelet Compounds of Garlic Ex Vivo
    Larry Lawson; Fiscal Year: 2005
    ..abstract_text> ..
  8. NEW DEVELOPMENTS IN ORGANOCOPPER CHEMISTRY
    R Dieter; Fiscal Year: 2004
    ..The proposed synthetic routes to pyrrolidine aza sugars will develop the potential synthetic power of alpha-aminoalkylcuprate chemistry. ..
  9. PRACTICAL CHEMICAL SYNTHESIS OF COMPLEX ALKALOIDS
    LARRY OVERMAN; Fiscal Year: 2009
    ....
  10. Ethanol Effects on Antigen Presentation in Liver Cells
    Natalia Osna; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  11. Thiol-Ene Polymers as Dental Restorative Materials
    NEIL CRAMER; Fiscal Year: 2006
    ..The compatibility of monomer formulations with filler particles and the properties of filled systems will be evaluated. Biocompatibility of the new dental restorative materials will also be assessed. ..
  12. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Chung Yang; Fiscal Year: 2005
    ..Jointly, we intend to make major contributions to the use of tea for the I chemoprevention of cancer. ..
  13. NOVEL GST AND DETOXICATION OF DIOL EPOXIDES
    Shivendra Singh; Fiscal Year: 2006
    ..In the long-term, this knowledge will guide us in developing strategies for prevention of PAH-induced cancers in humans. ..
  14. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  15. STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
    P Evans; Fiscal Year: 2006
    ..Finally, we will examine a series bismuth-catalyzed bis-reductive etherification reactions for the construction of linear fused polycyclic ethers. ..
  16. NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
    P Evans; Fiscal Year: 2006
    ..The development of a temporary silicon-tethered (TST) rhodium-catalyzed [4+2+2] carbocyclization approach to the diterpene, epoxydictymene. ..
  17. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2007
    ..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
  18. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  19. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  20. FOLATE AMINOBORONIC ACIDS AS TARGETED ANTI-CANCER AGENTS
    VENKATRAM MEREDDY; Fiscal Year: 2008
    ..These molecules could act as targeted molecules for folate receptor overexpressing cancer lines and may be useful for especially for the treatment of metastasized and relapsed cancers. [unreadable] [unreadable] [unreadable]..
  21. Synthesis of anticancer agents using Prins cyclization
    Scott Rychnovsky; Fiscal Year: 2007
    ..These tools will facilitate the synthesis of many new structures that may be important as new pharmaceutical agents. ..
  22. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  23. ALA & EPA/DHA (w-3) Effects On Inflammatory Markers in Insulin Resistant Adults
    Christopher Gardner; Fiscal Year: 2007
    ..The adults with the metabolic syndrome selected for this study are those that are at increased risk of heart disease, and those most likely to be benefit from the different therapies tested. [unreadable] [unreadable] [unreadable]..
  24. Effect of Antioxidants on Inflammatory Markers and FMVD
    Christopher Gardner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. Metal-Mediated Routes to Biaryls
    Bruce Lipshutz; Fiscal Year: 2007
    ..A particular, albeit representative, application of a novel substituted cyclo-NOBIN will be studied for selected asymmetric aldol reactions. ..
  26. Synthetic Antibodies by Monomolecular Imprinting
    Steven Zimmerman; Fiscal Year: 2007
    ..Applications in medical diagnostics are the most likely early pay-off for this technology. ..
  27. Reactivation Methylation-Silenced Genes by Polyphenols
    Chung Yang; Fiscal Year: 2007
    ..5. To determine whether EGCG, alone or in combination with other agents, can prevent hypermethylation of genes and tumor development in the intestinal tumorigenesis model in the Min mice. ..
  28. TETHERED NUCLEOBASES FOR ENHANCED DNA RECOGNITION
    Steven Zimmerman; Fiscal Year: 2005
    ..These include the use of super-bases in therapeutic oligonucleotides (e.g., antisense), detection of SNPs, as nonprocessable duplex anchors for chemical and molecular biology studies, etc. ..
  29. Toxicological Relevance of Human GST P1-1 Polymorphism
    Shivendra Singh; Fiscal Year: 2005
    ..abstract_text> ..
  30. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  31. Benefits & Risks of Popular Weight Loss Diets
    Christopher Gardner; Fiscal Year: 2003
    ..The data generated from this preliminary/feasibility study will be used to strengthen the proposal and design of a future full-scale study. ..
  32. MECHANISM OF ANTICARCINOGENIC ACTIVITY--ORGANOSULFIDES
    Shivendra Singh; Fiscal Year: 2003
    ..Insights gained from these studies should help in devising practical dietary recommendation for humans. ..
  33. ROLE OF HUMAN GST PI POLYMORPHISM IN DRUG RESISTANCE
    Shivendra Singh; Fiscal Year: 2003
    ..These studies, in the long term, may be valuable in identifying subjects that may be at a higher risk for developing GST-mediated resistance to some alkylating agents. ..
  34. PERMEATION OF IRRITANT MIXTURES THRU PROTECTIVE MATERIAL
    SHANE QUE HEE; Fiscal Year: 2002
    ..The relationship of the fundamental independent variables to the kinetic parameters of permeation and to the Corrositex rating as the index of irritation will be determined and compared. ..
  35. Inductively Coupled Plasma- Mass Spectrometer
    SHANE QUE HEE; Fiscal Year: 2003
    ..A team of researchers has been assembled whose research needs for elemental analyses are in the broad areas of environmental health, nutrition, biomedical and behavioral research. ..
  36. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  37. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  38. DENDRIMERS--POLYMERS FOR SELF ASSEMBLY AND DRUG DELIVERY
    Steven Zimmerman; Fiscal Year: 2001
    ..The strategy involves the chemical cross-linking of a dendrimer surface, followed by the chemical cleavage of labile internal bonds to chemically excise the core. ..
  39. CHEMICAL ACCESS TO CANCER RELEVANT CARBOHYDRATES
    GLENN MCGARVEY; Fiscal Year: 2001
    ..The present methodology will be merged with existing synthetic technology to efficiently prepare key oligosaccharides in sufficient quantity and purity for subsequent evaluation. ..
  40. Acquisition of a 500 MHz NMR Spectrometer
    Scott Rychnovsky; Fiscal Year: 2004
    ..This new instrument will bring much needed new capabilities to the NMR facility and will greatly facilitate the research programs of the PI and co-PIs of this proposal. ..
  41. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  42. Chemoprevention of Esophageal Squamous Cell Carcinoma
    Gary Stoner; Fiscal Year: 2004
    ..abstract_text> ..
  43. Alkyllithium Cyclizations in Organic Snythesis
    Scott Rychnovsky; Fiscal Year: 2005
    ..These compounds are of interest to synthetic and medicinal chemists, and have the types of rigid, polycyclic and polar structures found to show high bioactivity in many assays. ..
  44. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  45. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  46. Reduction of Amyloid Burden by Antisense APP
    Neelima Chauhan; Fiscal Year: 2005
    ..Significance: Targeting the translation of amyloidogenic APP by antisense synthetic oligodeoxynucleotides may prove to be an effective and safe form of gene therapy for treating familial AD and other genetic diseases. ..
  47. Determining Therapeutic Efficacy of AGE in AD
    Neelima Chauhan; Fiscal Year: 2005
    ..If successful, this project will validate the use of safe, naturally well-tolerated, cost-effective and alternative herbal pharmacotherapy for treating AD. ..
  48. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
    ..The applicant and colleagues will address key issues concerning the bioavailability and bioactivities of O-methyl, glucuronide, and sulfate derivatives and two ring-fission metabolites of tea catechins. ..
  49. Comparing Effects of 3 Sources of Garlic on Serum Lipids
    Christopher Gardner; Fiscal Year: 2005
    ..The comprehensive approach taken in this study will provide important evidence for both the public and for health professionals as to whether fresh garlic or garlic supplements have beneficial effects on serum lipids. ..
  50. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  51. FINE TUNING BINOLS AND BINAPS FOR ASYMMETRIC SYNTHESIS
    Bruce Lipshutz; Fiscal Year: 2001
    ..From ligands of this type come further options, such as opportunities for polymer mounting, and potentially of greatest attention, conversion to substituted cyclo BINAPs. ..