methyl ethers

Summary

Summary: A group of compounds that contain the general formula R-OCH3.

Top Publications

  1. ncbi Sevoflurane preconditioning induces neuroprotection through reactive oxygen species-mediated up-regulation of antioxidant enzymes in rats
    Qianzi Yang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Anesth Analg 112:931-7. 2011
  2. ncbi Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition
    Benjamin Drenger
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Anesthesiology 114:1364-72. 2011
  3. ncbi Sevoflurane impairs memory consolidation in rats, possibly through inhibiting phosphorylation of glycogen synthase kinase-3β in the hippocampus
    Xue Sheng Liu
    Department of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, PR China
    Neurobiol Learn Mem 94:461-7. 2010
  4. ncbi Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
    Maiko Satomoto
    Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 110:628-37. 2009
  5. pmc Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice
    Yan Lu
    Geriatric Anesthesia Research Unit, Departmentof Anesthesia, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    Anesthesiology 112:1404-16. 2010
  6. ncbi Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia
    Nurdan Bedirli
    Department of Anesthesiology, Gazi University Medical School, Ankara, Turkey
    J Neurosurg Anesthesiol 24:336-44. 2012
  7. ncbi Inhibition of sevoflurane postconditioning against cerebral ischemia reperfusion-induced oxidative injury in rats
    Yan Zhang
    Department of Anesthesiology, Tianjin Huanhu Hospital, Tianjin 300060, China
    Molecules 17:341-54. 2012
  8. ncbi Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils
    Chung Hang Wong
    Department of Anesthesiology, Chang Gung Memorial Hospital at Chiayi, and ChiaYi School, Chang Gung Institute of Technology, Puzih City, Chiayi County 613, Taiwan, ROC
    Food Chem Toxicol 44:1399-407. 2006
  9. ncbi Volatile anesthetic preconditioning attenuated sepsis induced lung inflammation
    Nurdan Bedirli
    Department of Anaesthesiology, Gazi University, Ankara, Turkey
    J Surg Res 178:e17-23. 2012
  10. ncbi The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping
    Pilar Sanchez-Conde
    Department of Anesthesiology, University Hospital of Salamanca, Salamanca, Spain
    Anesth Analg 106:371-8, table of contents. 2008

Detail Information

Publications288 found, 100 shown here

  1. ncbi Sevoflurane preconditioning induces neuroprotection through reactive oxygen species-mediated up-regulation of antioxidant enzymes in rats
    Qianzi Yang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Anesth Analg 112:931-7. 2011
    ....
  2. ncbi Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition
    Benjamin Drenger
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Anesthesiology 114:1364-72. 2011
    ..To determine whether postC cardioprotection can be restored by normoglycemia, we treated rats with insulin...
  3. ncbi Sevoflurane impairs memory consolidation in rats, possibly through inhibiting phosphorylation of glycogen synthase kinase-3β in the hippocampus
    Xue Sheng Liu
    Department of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, PR China
    Neurobiol Learn Mem 94:461-7. 2010
    ..Sevoflurane-induced amnesia may be due, at least in part, to suppression of GSK-3β phosphorylation in the hippocampus...
  4. ncbi Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
    Maiko Satomoto
    Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 110:628-37. 2009
    ..The authors investigated whether exposure of neonatal mice to inhaled sevoflurane causes deficits in social behavior as well as learning disabilities...
  5. pmc Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice
    Yan Lu
    Geriatric Anesthesia Research Unit, Departmentof Anesthesia, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    Anesthesiology 112:1404-16. 2010
    ....
  6. ncbi Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia
    Nurdan Bedirli
    Department of Anesthesiology, Gazi University Medical School, Ankara, Turkey
    J Neurosurg Anesthesiol 24:336-44. 2012
    ....
  7. ncbi Inhibition of sevoflurane postconditioning against cerebral ischemia reperfusion-induced oxidative injury in rats
    Yan Zhang
    Department of Anesthesiology, Tianjin Huanhu Hospital, Tianjin 300060, China
    Molecules 17:341-54. 2012
    ..It can be concluded that sevoflurane postconditioning may decrease blood and brain oxidative injury and enhance immunity indexes in cerebral ischemia reperfusion rats...
  8. ncbi Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils
    Chung Hang Wong
    Department of Anesthesiology, Chang Gung Memorial Hospital at Chiayi, and ChiaYi School, Chang Gung Institute of Technology, Puzih City, Chiayi County 613, Taiwan, ROC
    Food Chem Toxicol 44:1399-407. 2006
    ..Exposure of PMN to sevoflurane markedly increased apoptosis in a dose-dependent manner. In summary, these results are important for demonstrating the oxidative stress and cellular injury on sevoflurane-treated human PMN...
  9. ncbi Volatile anesthetic preconditioning attenuated sepsis induced lung inflammation
    Nurdan Bedirli
    Department of Anaesthesiology, Gazi University, Ankara, Turkey
    J Surg Res 178:e17-23. 2012
    ..This study aimed to evaluate the differential protective effects of isoflurane or sevoflurane on lung inflammation in a rat model of cecal ligation and puncture (CLP) induced sepsis...
  10. ncbi The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping
    Pilar Sanchez-Conde
    Department of Anesthesiology, University Hospital of Salamanca, Salamanca, Spain
    Anesth Analg 106:371-8, table of contents. 2008
    ..We compared the effect of propofol with sevoflurane on kidney NFkappaB expression and systemic inflammatory responses induced by aortic clamping...
  11. ncbi Sevoflurane preserves the endothelial glycocalyx against ischaemia-reperfusion injury
    T Annecke
    Clinic of Anaesthesiology, Ludwig Maximilians University Munich, Germany
    Br J Anaesth 104:414-21. 2010
    ..We evaluated the effect of cardiac pre- and post-conditioning with sevoflurane on integrity of the endothelial glycocalyx in conjunction with coronary vascular function...
  12. pmc Comparison of emergence time in children undergoing minor surgery according to anesthetic: desflurane and sevoflurane
    Jeong Min Kim
    Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 54:732-8. 2013
    ..We undertook this study to determine which agents prompt less recovery time in pediatric patients undergoing minor surgery...
  13. ncbi Sevoflurane preconditioning induces rapid ischemic tolerance against spinal cord ischemia/reperfusion through activation of extracellular signal-regulated kinase in rabbits
    Qian Ding
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Anesth Analg 109:1263-72. 2009
    ....
  14. ncbi Sevoflurane-induced preconditioning: impact of protocol and aprotinin administration on infarct size and endothelial nitric-oxide synthase phosphorylation in the rat heart in vivo
    Jan Frädorf
    Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 113:1289-98. 2010
    ..We investigated (1) whether SevoPC is strengthened by multiple preconditioning cycles, (2) whether SevoPC is blocked by aprotinin, and (3) whether endothelial NOS plays a crucial role in SevoPC...
  15. ncbi Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia?
    Mohanad Shukry
    Department of Anesthesiology, Tulane University, New Orleans, LA, USA
    Paediatr Anaesth 15:1098-104. 2005
    ..We studied the effects of a continuous perioperative infusion of 0.2 microg.kg(-1).h(-1) dexmedetomidine on the incidence of ED in 50 children aged 1-10 years scheduled for sevoflurane-based GA...
  16. ncbi State of the art: sedation concepts with volatile anesthetics in critically Ill patients
    Jens Soukup
    Department of Anaesthesiology and Intensive Care, University Hospital Martin Luther University Halle Wittenberg, D 06120 Halle, Germany
    J Crit Care 24:535-44. 2009
    ..The use of volatile anesthetics on the ICU could adopt a permanent position in various intensive care analgosedation concepts in future. It may be possible thereby to optimize the treatment process both in medical and economical terms...
  17. ncbi Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1
    Koichi Yuki
    Department of Anesthesiology, Perioperative and Pain Medicine, Children s Hospital Boston, and Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 113:600-9. 2010
    ..It remains to be determined whether the allosteric inhibition of LFA-1 by isoflurane can be generalized to other anesthetics such as sevoflurane...
  18. ncbi Sevoflurane protects against acute kidney injury in a small-size liver transplantation model
    H Y Kong
    Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
    Am J Nephrol 32:347-55. 2010
    ....
  19. ncbi Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam
    Malcie Mesnil
    Department of Anesthesiology and Critical Care Lapeyronie DAR A, Montpellier I University and Montpellier University Lapeyronie Hospital, Institut National de la Sante et de la Recherche Medicale INSERM, Equipe soutenue par la Région et l Inserm ERI 25, route de Ganges, 34295 Montpellier, Cedex 5, France
    Intensive Care Med 37:933-41. 2011
    ..To evaluate efficacy and adverse events related to inhaled sevoflurane for long-term sedation compared with standard intravenous (i.v.) sedation with propofol or midazolam...
  20. ncbi Effects of sevoflurane general anesthesia: immunological studies in mice
    N R Puig
    Institute of Immunology, School of Medicine, National University of Rosario, Santa Fe, Argentina
    Int Immunopharmacol 2:95-104. 2002
    ....
  21. pmc The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels
    Yuanlin Dong
    Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arch Neurol 66:620-31. 2009
    ..Subjects Naive mice, H4 human neuroglioma cells, and H4 human neuroglioma cells stably transfected to express full-length amyloid precursor protein...
  22. ncbi Comparison of surgical conditions during propofol or sevoflurane anaesthesia for endoscopic sinus surgery
    H J Ahn
    Department of Anaesthesiology and Pain Medicine, Sungkyunkwan University School of Medicine 135 710, 50 Ilwon Dong, Kangnam Ku, Seoul, Korea
    Br J Anaesth 100:50-4. 2008
    ..This study compared the surgical condition and the amount of intra-nasal bleeding between patients given sevoflurane/remifentanil (SR) and propofol/remifentanil (PR) anaesthesia...
  23. ncbi The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: effects of TM2 mutations in the alpha and beta subunits
    Koichi Nishikawa
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi City, Japan
    Anesthesiology 99:678-84. 2003
    ..The aim of this study was to examine the effects of sevoflurane and desflurane on potentiation of GABA-induced responses in the wild-type GABAA receptor and in receptors mutated in TM2 of the alpha1, alpha 2, or beta 2 subunits...
  24. ncbi Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats
    Michael T Alkire
    Department of Anesthesiology, and Center for the Neurobiology of Learning and Memory, University of California Irvine, 101 The City Drive South, Bldg 53, Route 81 A, Orange, CA 92868, USA
    Anesthesiology 103:1167-73. 2005
    ..1 minimum alveolar concentration. This issue was investigated in a rat model of learning and memory. In addition, evidence for basolateral amygdala (BLA) involvement in mediating memory enhancement was sought...
  25. ncbi Sevoflurane inhalation at sedative concentrations provides endothelial protection against ischemia-reperfusion injury in humans
    Eliana Lucchinetti
    Institute of Anesthesiology, University Hospital Zurich, Switzerland
    Anesthesiology 106:262-8. 2007
    ..The authors tested whether inhalation of sevoflurane at subanesthetic concentrations provides protection against postocclusive endothelial dysfunction induced by ischemia-reperfusion injury of the forearm in humans...
  26. ncbi Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers
    Renata Mikstacka
    Department of Pharmaceutical Biochemistry, University of Medical Sciences, Poznan, Poland
    Mol Nutr Food Res 51:517-24. 2007
    ..The results suggest that the trans-resveratrol analogues: pinostilbene, desoxyrhapontigenin and pterostilbene, which occur in some food plants, might be considered as promising chemopreventive agents...
  27. ncbi Influence of inhalation anesthesia assessed by comprehensive gene expression profiling
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Gene 356:39-48. 2005
    ..Our findings provide the first assessment for the influence of inhalation anesthesia by approaches of experimental biology and genome science...
  28. ncbi Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly
    Denise Rohan
    Department of Anesthesia, Critical Care and Pain Medicine, Mater Misericordiae Hospital, Eccles Street, Dublin 7, Ireland
    Can J Anaesth 52:137-42. 2005
    ....
  29. ncbi Preconditioning, but not postconditioning, with Sevoflurane reduces pulmonary neutrophil accumulation after lower body ischaemia/reperfusion injury in rats
    R Kalb
    Heinrich Heine University Dusseldorf, Department of Anaesthesiology, Dusseldorf, Germany
    Eur J Anaesthesiol 25:454-9. 2008
    ..We tested the hypothesis that pre- or postconditioning with Sevoflurane attenuates pulmonary neutrophil accumulation after ischaemia/reperfusion injury of the aorta...
  30. ncbi Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing
    Paul F White
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9068, USA
    Anesth Analg 109:387-93. 2009
    ..Furthermore, the effect of desflurane (versus sevoflurane) on the incidence of coughing is also controversial...
  31. ncbi Photochemical reaction mechanisms of 2-nitrobenzyl compounds: methyl ethers and caged ATP
    Yuri V Il'ichev
    Departement Chemie der Universität Basel, Klingelbergstr 80, CH 4056 Basel, Switzerland
    J Am Chem Soc 126:4581-95. 2004
    ..This observation is in contrast to a recent claim for related 2-nitrobenzyl methyl ethers (Corrie et al.)...
  32. ncbi Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies
    S Dahmani
    Department of Anesthesiology, Robert Debre University Hospital, Assistance Publique des Hopitaux de Paris, 48 Bd Serurier, 75019 Paris, France
    Br J Anaesth 104:216-23. 2010
    ..The efficacy of prophylactic treatment is controversial. The aim of this study was to provide a meta-analysis of the studies of the pharmacological prevention of EA in children...
  33. ncbi Effect of increased body mass index and anaesthetic duration on recovery of protective airway reflexes after sevoflurane vs desflurane
    R E McKay
    Department of Anaesthesia and Perioperative Care, C 450, University of California San Francisco, San Francisco, CA 94143 0648, USA
    Br J Anaesth 104:175-82. 2010
    ..Increased BMI may increase the body's capacity to store potent inhaled anaesthetics, more so with more soluble agents. Accordingly, we asked whether increased BMI and longer anaesthesia prolonged airway reflex recovery...
  34. ncbi Object memory in young and aged mice after sevoflurane anaesthesia
    Andreas Wiklund
    Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden
    Neuroreport 20:1419-23. 2009
    ..Sevoflurane anaesthesia thus causes memory impairment in mice regardless of beta2 receptor-mediated nicotinic cholinergic neurotransmission...
  35. ncbi Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery
    Berrin Isik
    Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara, Turkey
    Paediatr Anaesth 16:748-53. 2006
    ..The purpose of the present study was to determine whether prophylactic use of 1 microg x kg(-1) dexmedetomidine affected the incidence of emergence agitation (EA) after sevoflurane based anesthesia without surgery in children...
  36. ncbi Cognitive function after sevoflurane- vs propofol-based anaesthesia for on-pump cardiac surgery: a randomized controlled trial
    J Schoen
    Department of Anesthesiology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Br J Anaesth 106:840-50. 2011
    ..This study was designed to determine cognitive and clinical outcomes after sevoflurane- compared with propofol-based anaesthesia for on-pump cardiac surgery and the impact of decreases in under different anaesthesia regimens...
  37. ncbi Sevoflurane in paediatric anaesthesia: a review
    K L Goa
    Adis International Limited, Auckland, New Zealand
    Paediatr Drugs 1:127-53. 1999
    ..As well, pharmacoeconomic analyses are scarce and incompletely published; further studies are needed to determine whether shortened times to emergence will translate into cost savings...
  38. ncbi Gender-related difference of sevoflurane postconditioning in isolated rat hearts: focus on phosphatidylinositol-3-kinase/Akt signaling
    Zhoupeng Zheng
    Department of Anesthesiology, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    J Surg Res 170:e3-9. 2011
    ..The purpose of the present study was to determine whether the cardioprotection of sevoflurane postconditioning is influenced by gender, and the role of PI3K/Akt pathway in such gender difference...
  39. pmc Pharmacological postconditioning with sevoflurane after cardiopulmonary resuscitation reduces myocardial dysfunction
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, Schleswig Holstein University Hospital, Campus Kiel, Schwanenweg 21, D 24105 Kiel, Germany
    Crit Care 15:R241. 2011
    ..In this study, we sought to examine whether pharmacological postconditioning with sevoflurane (SEVO) is neuro- and cardioprotective in a pig model of cardiopulmonary resuscitation...
  40. ncbi Thiopental-induced burst suppression measured by the bispectral index is extended during propofol administration compared with sevoflurane
    Jun Rho Yoon
    Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
    J Neurosurg Anesthesiol 24:146-51. 2012
    ..The effect of thiopental was measured by burst suppression ratio (BSR) using the bispectral index (BIS) monitor...
  41. ncbi Time-dependent repression of mPer2 expression in the suprachiasmatic nucleus by inhalation anesthesia with sevoflurane
    Kana Kadota
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Neurosci Lett 528:153-8. 2012
    ..Further investigation into the molecular events caused by anesthesia are required to explain atypical clinical signs observed in patients after surgical procedures, such as fatigue, sleep disorder, mood alteration and delirium...
  42. ncbi Sevoflurane preconditioning improves mitochondrial function and long-term neurologic sequelae after transient cerebral ischemia: role of mitochondrial permeability transition
    Ruidong Ye
    Department of Neurology, Fourth Military Medical University, Xi an, China
    Crit Care Med 40:2685-93. 2012
    ....
  43. ncbi The application of dexmedetomidine in children undergoing vitreoretinal surgery
    Xu Lili
    Department of Anesthesiology, The Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China
    J Anesth 26:556-61. 2012
    ..We focused on these effects in this study...
  44. ncbi Effect of single-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery
    Masami Sato
    Department of Anesthesia, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Anesth 24:675-82. 2010
    ..To study the effects of dexmedetomidine (DEX), a selective α(2)-adrenoreceptor agonist, on emergence agitation (EA), recovery profiles, and parents' satisfaction after sevoflurane anesthesia in pediatric ambulatory surgery...
  45. ncbi Dexmedetomidine reduces emergence agitation after tonsillectomy in children by sevoflurane anesthesia: a case-control study
    Qing tao Meng
    Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Int J Pediatr Otorhinolaryngol 76:1036-41. 2012
    ..To evaluate the efficacy and safety of dexmedetomidine for emergence agitation after tonsillectomy in children...
  46. ncbi Sevoflurane preconditioning confers neuroprotection via anti-inflammatory effects
    Hailian Wang
    State Key Laboratory of Medical Neurobiology, Department of Anesthesiology of Huashan Hospital, Fudan University, Shanghai, China
    Front Biosci (Elite Ed) 3:604-15. 2011
    ..Thus, the data suggest that APC with sevoflurane confers neuroprotection against focal ischemic brain injury, at least in part, by the anti-inflammatory effects of sevoflurane...
  47. ncbi The general anesthetic sevoflurane affects the expression of clock gene mPer2 accompanying the change of NAD+ level in the suprachiasmatic nucleus of mice
    Yumiko Ohe
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Sendagi 1 1 5, Bunkyo ku, Tokyo 113 8602, Japan
    Neurosci Lett 490:231-6. 2011
    ..Furthermore, the modification of mPer2 expression by the anesthesia is considered to affect various gene expressions...
  48. ncbi Fluorinated groups mediate the immunomodulatory effects of volatile anesthetics in acute cell injury
    Martin Urner
    Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Am J Respir Cell Mol Biol 45:617-24. 2011
    ....
  49. ncbi Comparison of propofol and sevoflurane anesthesia by means of blood loss during endoscopic sinus surgery
    Remziye Sivaci
    Department of Anesthesiology, Kocatepe University, School of Medicine, Afyon, Turkey
    Saudi Med J 25:1995-8. 2004
    ..The purpose of the present investigation is to examine whether induced hypotension with propofol or sevoflurane anesthesia improves the dryness of surgical field in endoscopic sinus surgery (ESS)...
  50. ncbi Sevoflurane post-conditioning protects against myocardial reperfusion injury by activation of phosphatidylinositol-3-kinase signal transduction
    Heng Li
    Department of Anaesthesiology, Affiliated Hospital of First Clinical College, China Medical University, Shenyang, China
    Clin Exp Pharmacol Physiol 35:1043-51. 2008
    ..The combination of sevoflurane plus ischaemic post-conditioning does not offer any additional benefit over either intervention alone...
  51. ncbi Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethers
    Hugh E Criswell
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1015:107-13. 2004
    ..These data indicate that a wide variety of volatile hydrocarbon based CNS depressants produce a similar inhibition of NMDA-gated currents and that the kinetics for these agents are inconsistent with an open channel block...
  52. ncbi Inhalation anesthetics induce apoptosis in normal peripheral lymphocytes in vitro
    H Matsuoka
    Department of Anesthesiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Anesthesiology 95:1467-72. 2001
    ..Therefore, they evaluated whether sevoflurane and isoflurane induce apoptosis of normal peripheral lymphocytes...
  53. ncbi Comparison of genotoxicity of sevoflurane and isoflurane in human lymphocytes studied in vivo using the comet assay
    L Karabiyik
    Department of Anaesthesia, Turkish State Railways Hospital, 06330, Ankara, Turkey
    Mutat Res 492:99-107. 2001
    ....
  54. ncbi Effects of repetitive sevoflurane anaesthesia on immune response, select biochemical parameters and organ histology in mice
    G Elena
    Department of Anaesthesiology, National University of Rosario, Rosario, Argentina
    Lab Anim 37:193-203. 2003
    ..Nevertheless, sevoflurane-treated animals showed no evidence of histological changes or alteration in hepatic or renal function...
  55. ncbi Isoflurane and sevoflurane induce vasodilation of cerebral vessels via ATP-sensitive K+ channel activation
    H Iida
    Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine, Japan
    Anesthesiology 89:954-60. 1998
    ....
  56. ncbi Evidence of acute tolerance to remifentanil in intensive care but not in anesthesia
    Vincenzo Fodale
    Department of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, School of Medicine, Policlinico Universitario G Martino, 98125 Messina, Italy
    J Clin Anesth 18:293-6. 2006
    ..It is of interest for anesthesiologists, given the high frequency of patients with drug abuse history who are admitted to intensive care units, often sedated with remifentanil, who undergo anesthesia for emergency surgery...
  57. ncbi The immunomodulatory effect of sevoflurane in endotoxin-injured alveolar epithelial cells
    Dominik Suter
    Institute of Anesthesiology, University of Zurich, Zurich, Switzerland
    Anesth Analg 104:638-45. 2007
    ..In this study we investigated the effect of pretreatment with the inhaled anesthetic sevoflurane on lipopolysaccharide (LPS)-injured AEC...
  58. ncbi Single vital-capacity and successive tidal-volume breathing of sevoflurane in induction of anesthesia for tracheal intubation in gynecologic patients
    Tso Chou Lin
    Department of Anesthesiology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan, R O C
    Acta Anaesthesiol Taiwan 46:66-70. 2008
    ..This study was designed to investigate the time effect of fast wash-in of alveolar sevoflurane in induction of anesthesia for tracheal intubation with single vital-capacity and ensuing tidal-volume breathing in gynecologic patients...
  59. ncbi Sevoflurane postconditioning protects isolated rat hearts against ischemia-reperfusion injury
    Yun tai Yao
    Department of Anesthesiology, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
    Chin Med J (Engl) 123:1320-8. 2010
    ....
  60. ncbi Clinical pharmacokinetics of sevoflurane
    M Behne
    Klinik fur Anasthesiologie, Intensivmedzin und Schmerztherapie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Clin Pharmacokinet 36:13-26. 1999
    ..Whether inorganic fluoride or compound A are nephrotoxic is presently a matter of controversy...
  61. ncbi Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets
    Christian Grasshoff
    Section of Experimental Anesthesiology, Department of Anesthesiology, University of Tuebingen, Germany
    Anesthesiology 101:1167-76. 2004
    ..The relevant molecular targets of the commonly used volatile anesthetic sevoflurane in the spinal cord are largely unknown, but indirect evidence suggests a mechanism of action distinct from propofol...
  62. ncbi Comparison of early cognitive function and recovery after desflurane or sevoflurane anaesthesia in the elderly: a double-blinded randomized controlled trial
    D Rörtgen
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52072 Aachen, Germany
    Br J Anaesth 104:167-74. 2010
    ..We hypothesized that the use of the shorter-acting volatile anaesthetic desflurane would be associated with less incidence of POCD when compared with sevoflurane...
  63. ncbi Emergence times are similar with sevoflurane and total intravenous anesthesia: results of a multicenter RCT of patients scheduled for elective supratentorial craniotomy
    Enrico Lauta
    Anesthesia and Intensive Care Unit I, Azienda Ospedaliero Universitaria Consorziale Policlinico, Bari, Italy
    J Neurosurg Anesthesiol 22:110-8. 2010
    ....
  64. ncbi Sevoflurane and epileptiform EEG changes
    Isabelle Constant
    Service d Anesthesie Reanimation, Hopital d Enfants Armand Trousseau, Assistance Publique, Hopitaux de Paris, Paris VI University, Paris, France
    Paediatr Anaesth 15:266-74. 2005
    ....
  65. ncbi Nuclear factor kappaB and anesthetic preconditioning during myocardial ischemia-reperfusion
    Caiyun Zhong
    Department of Anesthesiology and Pain Medicine, University of California, Davis, Davis, California 95817, USA
    Anesthesiology 100:540-6. 2004
    ..To investigate the molecular mechanism of APC in myocardial protection, the activation of nuclear factor (NF) kappaB and its regulated inflammatory mediators expression were examined in the current study...
  66. ncbi Sevoflurane preconditioning against focal cerebral ischemia: inhibition of apoptosis in the face of transient improvement of neurological outcome
    Jean Laurent Codaccioni
    Laboratoire de Pharmacodynamie, UMR INSERM 608, Faculté de Pharmacie 27 bd, Jean Moulin, Marseille, France
    Anesthesiology 110:1271-8. 2009
    ..However, it is uncertain whether this preconditioning effect extends over a longer period of time. The purpose of this study was to determine if sevoflurane preconditioning offers durable neuroprotection against cerebral ischemia...
  67. ncbi Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model
    Yan Luo
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Anesthesiology 109:782-9. 2008
    ..Xenon and sevoflurane may be used as inhalational analgesics for labor. Therefore, the authors investigated the potential application of these agents independently and in combination to attenuate perinatal injury...
  68. ncbi The effect of the total intravenous anesthesia compared with inhalational anesthesia on the surgical field during endoscopic sinus surgery
    Peter J Wormald
    Department of Surgery Otolaryngology, Head and Neck Surgery, The University of Adelaide and Flinders University, Adelaide, South Australia
    Am J Rhinol 19:514-20. 2005
    ..The aim of this study was to compare the surgical field in patients in whom total intravenous anesthesia (TIVA) is used as opposed to inhalation anesthesia. A prospective randomized controlled trial was performed...
  69. ncbi Cytoprotective effects of the volatile anesthetic sevoflurane are highly dependent on timing and duration of sevoflurane conditioning: findings from a human, in-vitro hypoxia model
    Karina Zitta
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Eur J Pharmacol 645:39-46. 2010
    ..Our results suggest short pre- and intraconditioning with sevoflurane as most potent strategies to reduce hypoxia induced neuronal cell damage...
  70. ncbi Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 291:F67-78. 2006
    ..These mechanisms may, in part, account for volatile anesthetics' protective effects against renal IR injury...
  71. ncbi Direct cerebral vasodilatory effects of sevoflurane and isoflurane
    B F Matta
    Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    Anesthesiology 91:677-80. 1999
    ..This study compared the direct cerebral vasodilatory actions of 0.5 and 1.5 minimum alveolar concentration (MAC) sevoflurane and isoflurane during an propofol-induced isoelectric electroencephalogram...
  72. ncbi Statistical modeling of average and variability of time to extubation for meta-analysis comparing desflurane to sevoflurane
    Franklin Dexter
    Department of Anesthesia, University of Iowa, Iowa City, Iowa 52242, USA
    Anesth Analg 110:570-80. 2010
    ..We applied that knowledge for meta-analyses of trials comparing extubation times after use of desflurane and sevoflurane...
  73. pmc Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies
    Hui Yang
    Department of Anesthesiology and Critical Care, University of Pennsylvania, PA, USA
    Anesthesiology 109:243-50. 2008
    ....
  74. ncbi The effect of fentanyl on the emergence characteristics after desflurane or sevoflurane anesthesia in children
    Ira Todd Cohen
    Department of Anesthesiology, Children s National Medical Center, Washington, DC 20010, USA
    Anesth Analg 94:1178-81, table of contents. 2002
    ..In children receiving desflurane or sevoflurane, the concurrent use of fentanyl in a dose of 2.5 microg/kg results in a small incidence of emergence agitation...
  75. ncbi The influence of mitochondrial KATP-channels in the cardioprotection of preconditioning and postconditioning by sevoflurane in the rat in vivo
    Detlef Obal
    Klinik fur Anaesthesiologie, Universitatsklinikum Dusseldorf, Postfach 10 10 07, D 40001 Dusseldorf, Germany
    Anesth Analg 101:1252-60. 2005
    ..The combination of preconditioning and postconditioning provides additive cardioprotection and is mediated, at least in part, by mKATP-channels...
  76. ncbi Comparison of the effects of sevoflurane and propofol on cooling and rewarming during deliberate mild hypothermia for neurosurgery
    T Iwata
    Department of Anesthesiology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Br J Anaesth 90:32-8. 2003
    ..We therefore investigated possible differences between sevoflurane and propofol on the decrease and recovery of core temperature during deliberate mild hypothermia for neurosurgery...
  77. ncbi The effects of sevoflurane and desflurane anesthesia on QTc interval and cardiac rhythm in children
    Ebru Aypar
    Section of Pediatric Cardiology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Paediatr Anaesth 17:563-7. 2007
    ..We assessed the effects of desflurane anesthesia on QTc interval and cardiac rhythm and compared them with sevoflurane anesthesia in children...
  78. ncbi Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol
    T Ikeda
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan
    Anesth Analg 88:921-4. 1999
    ..These data support our hypothesis that even a brief period of vasodilation causes substantial redistribution hypothermia that persists throughout surgery...
  79. ncbi Inhalational or intravenous anesthetics for craniotomies? Pro inhalational
    Kristin Engelhard
    Klinik fur Anasthesiologie, Johannes Gutenberg Universitat, Mainz, Germany
    Curr Opin Anaesthesiol 19:504-8. 2006
    ....
  80. ncbi Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia
    Kurt D Petersen
    Department of Anesthesia and Neurosurgery, Aarhus University Hospital, Denmark
    Anesthesiology 98:329-36. 2003
    ..Controlled studies concerning ICP, degree of dural tension, and degree of cerebral swelling are therefore warranted...
  81. pmc Volatile anesthetic post-treatment induces protection via inhibition of glycogen synthase kinase 3β in human neuron-like cells
    D Lin
    Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA
    Neuroscience 179:73-9. 2011
    ..Since phospho-GSK3β at Ser9 decreases GSK3β activity, our results suggest that volatile anesthetic post-conditioning in human neuron-like cells may be mediated by GSK3β inhibition...
  82. pmc Anesthetic potency and cardiopulmonary effects of sevoflurane in goats: comparison with isoflurane and halothane
    Y Hikasa
    Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Koyama Minami, Japan
    Can J Vet Res 62:299-306. 1998
    ..Halothane did not significantly alter systemic vascular resistance from 1 to 2 MAC...
  83. ncbi Convulsions on anaesthetic induction with sevoflurane in young children
    J Akeson
    Department of Anaesthesia and Intensive Care, Lund University, Malmo University Hospital, Malmo, Sweden
    Acta Anaesthesiol Scand 48:405-7. 2004
    ..Based on our observations and reports by others we suggest that, until further notice, sevoflurane should be avoided or at least used cautiously in patients where clinical epileptic activity has been verified or is strongly suspected...
  84. pmc The volatile anaesthetic sevoflurane attenuates lipopolysaccharide-induced injury in alveolar macrophages
    M Steurer
    Institute of Physiology, Zurich Center of Integrative Human Physiology, Zurich, Switzerland
    Clin Exp Immunol 155:224-30. 2009
    ..Pharmacological post-conditioning of alveolar macrophages with sevoflurane immunmodulates the inflammatory response upon stimulation with endotoxin. This might be a possible option for a therapeutical approach in ALI...
  85. ncbi Comparison of effective inspired concentration of sevoflurane in preterm infants with different postconceptual ages
    Ling Yu
    Department of Anesthesiology, Peking University People s Hospital, Beijing, China
    Paediatr Anaesth 21:148-52. 2011
    ....
  86. ncbi Effects of the water content of soda lime on compound A concentration in the anesthesia circuit in sevoflurane anesthesia
    H Bito
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan
    Anesthesiology 88:66-71. 1998
    ..This goal of this study was to determine if compound A concentrations can be reduced by using soda lime with water added...
  87. pmc Isoflurane causes greater neurodegeneration than an equivalent exposure of sevoflurane in the developing brain of neonatal mice
    Ge Liang
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 112:1325-34. 2010
    ..We hypothesized that isoflurane has a greater potency to induce neurodegeneration than sevoflurane in the developing brains of neonatal mice based on our previous studies in cell culture...
  88. ncbi Sevoflurane anaesthesia in children after induction of anaesthesia with midazolam and thiopental does not cause epileptiform EEG
    K Nieminen
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Br J Anaesth 89:853-6. 2002
    ..v. induction with benzodiazepine and barbiturate, which is another common induction technique in children...
  89. ncbi Desflurane increases intracranial pressure more and sevoflurane less than isoflurane in pigs subjected to intracranial hypertension
    Anders Holmström
    Department of Anesthesia and Intensive Care, Malmo University Hospital, Lund University, Malmo, Sweden
    J Neurosurg Anesthesiol 16:136-43. 2004
    ..The present study showed that desflurane increased ICP more and sevoflurane less than isoflurane during normoventilation, but the differences disappeared with hyperventilation...
  90. ncbi Quantitative analysis of changes in blood concentrations and 'presumed effect-site concentration' of sevoflurane during one-lung ventilation
    S Matsuse
    Department of Anaesthesia, Kasukabe Chuo General Hospital, Saitama, Japan
    Anaesthesia 67:1125-31. 2012
    ..3% but the mean (SD) presumed effect-site concentration declined initially from 58 (6.7) to 43 (4.7) μg.ml(-1) (p=0.011) before slowly recovering. A period of insufficient depth of anaesthesia is thus a risk during one-lung ventilation...
  91. ncbi Opposing effects of isoflurane and sevoflurane on neurogenic pulmonary edema development in an animal model
    Nobuhisa Kandatsu
    Aichi Medical University, Nagakute cho, Aichi Gun, Aichi Prefecture, Japan
    Anesthesiology 102:1182-9. 2005
    ..The current study was undertaken to investigate the effects of pretreatment with isoflurane and sevoflurane on the development of neurogenic pulmonary edema in an animal model...
  92. ncbi [Roles of glutamatergic and GABAergic nervous system in hypnotic and analgesic actions of general anesthetics]
    Koichi Nishikawa
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Masui 60:534-43. 2011
    ..In this mini review, the relative contributions of extrasynaptic GABA receptors in behavioral actions of isoflurane and sevoflurane will be discussed...
  93. ncbi Seizure-like movements during induction of anaesthesia with sevoflurane
    M Adachi
    Department of Dental Anesthesiology, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    Br J Anaesth 68:214-5. 1992
    ..No neurological abnormalities were obvious after the anaesthesia. The movements may have been the result of seizure activity in the central nervous system, or myoclonus of the extremities...
  94. ncbi The effects of sevoflurane and desflurane in vitro on platelet-leukocyte adhesion in whole blood
    N A Horn
    Department of Anaesthesiology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anaesthesia 58:312-9. 2003
    ..The results show that these two volatile anaesthetics have differing effects on the formation of platelet-leukocyte conjugates in vitro. Sevoflurane also enhanced the expression of P-selectin on platelets...
  95. ncbi Sharp transients in the EEGs of non-epileptic adult patients receiving sevoflurane
    A Schultz
    Medizinische Hochschule Hannover, Abt. Anaesthesie IV, Klinikum Hannover-Oststadt, Podbielskistrasse 380, D-30659 Hannover, Germany
    Pharm World Sci 23:82-5. 2001
    ..Taking into consideration that convulsive and nonconvulsive status epilepticus can be followed by signs of brain damage, it would appear to be important to further investigate the phenomenon...
  96. ncbi Analgesia with sevoflurane during labour: i. Determination of the optimum concentration
    S T Yeo
    Magill Department of Anaesthesia, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London W12 0HS, UK
    Br J Anaesth 98:105-9. 2007
    ..Sevoflurane has favourable physical qualities for inhaled analgesia during labour pain. The aim of this preliminary study was to identify its optimum concentration...
  97. ncbi Volatile anaesthetics induce biochemical alterations in the heme pathway in a B-lymphocyte cell line established from hepatoerythropoietic porphyria patients (LBHEP) and in mice inoculated with LBHEP cells
    Ana Maria Buzaleh
    Department of Biological Chemistry, Facultad de Ciencias Exactas y Naturales, Centro de Investigaciones sobre Porfirinas y Porfirias CIPYP, University of Buenos Aires, CONICET, Buenos Aires, Argentina
    Int J Biochem Cell Biol 36:216-22. 2004
    ....
  98. ncbi Epileptiform EEG during sevoflurane mask induction: effect of delaying the onset of hyperventilation
    A Vakkuri
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Finland
    Acta Anaesthesiol Scand 44:713-9. 2000
    ..We tested the hypothesis that delaying onset of hyperventilation will prevent severe (periodic) epileptiform EEG and hyperdynamic response...
  99. ncbi Topographic electroencephalogram in children during mask induction of anaesthesia with sevoflurane
    E Sonkajarvi
    Departmetn of Anaesthesiology, Oulu University Hospital, Oulu, Finland
    Acta Anaesthesiol Scand 53:77-84. 2009
    ..Published recordings have been performed with a limited number of channels, and therefore the topographic distributions of these patterns are not known...
  100. ncbi Comparison of the sedative, cognitive, and analgesic effects of nitrous oxide, sevoflurane, and ethanol
    R Duarte
    Department of Neuroscience, 1 George Square, Edinburgh EH8 9JZ, UK
    Br J Anaesth 100:203-10. 2008
    ..Anaesthetics which work by different mechanisms may have different patterns of effect. Measurement of these patterns thus may elucidate their mechanisms of action and allow therapeutic choices between the agents...
  101. ncbi Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells
    Martin Roesslein
    Department of Anesthesiology and Critical Care Medicine, University Hospital, Freiburg, Germany
    Anesth Analg 106:1150-60, table of contents. 2008
    ..Because p38 can be involved either in pro- or antiapoptotic processes, we examined whether the sevoflurane-induced apoptosis is mediated by p38 activation in Jurkat T-cells...

Research Grants24

  1. TOXICOLOGY FOR TEACHERS
    Ann de Peyster; Fiscal Year: 2003
    ..These workshops are an innovative way for scientists and teachers to work together to improve science education. ..
  2. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..abstract_text> ..
  3. ANESTHETIC RENAL METABOLISM--MECHANISMS AND CONSEQUENCES
    Evan Kharasch; Fiscal Year: 2002
    ..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
  4. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  5. Novel noninvasive assessment of cytochrome P450 activity
    Evan Kharasch; Fiscal Year: 2009
    ..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
  6. Hemodynamics and Outcome in Pediatric Brain Injury
    MONICA VAVILALA; Fiscal Year: 2007
    ..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
  7. Cerebral Edema in Pediatric Diabetic Ketoacidosis
    MONICA VAVILALA; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. Solvent Exposure: Functional Imaging and Behavior
    Nancy Fiedler; Fiscal Year: 2006
    ..abstract_text> ..
  9. Lead Exposure, HPA Axis Dysfunction, and Blood Pressure: Hypertension Risk
    Nancy Fiedler; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  10. FUNCTIONAL CHARACTERIZATION OF AGT GENETIC POLYMORPHISM
    Jun yan Hong; Fiscal Year: 2001
    ..It could have a significant impact on cancer prevention by identifying susceptible subpopulations in future epidemiological studies. ..
  11. FUNCT. CHARACTERIZATION OF HUMAN CYP2A6 GENETIC VARIANTS
    Jun yan Hong; Fiscal Year: 2002
    ....
  12. Mechanisms of peripheral vascular anesthetic sensitivity
    THOMAS STEKIEL; Fiscal Year: 2008
    ..Additionally, this model also greatly facilitates development of congenic sub strains (partial chromosomal substitutions) for use in subsequent genetic mapping studies. ..
  13. BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    James Zacny; Fiscal Year: 2009
    ..abstract_text> ..
  14. Neurophysiologic Development Responses to Surgery
    DOUGLAS RIRIE; Fiscal Year: 2007
    ..Through this and future studies which come from this data and training, improvement in understanding will hopefully lead to improved pain therapy that is developmentally appropriate. ..
  15. MECHANISMS OF MYOCARDIAL ISCHEMIC INJURY IN DIABETES
    Judy R Kersten; Fiscal Year: 2010
    ..abstract_text> ..
  16. COMPARATIVE MEDICAL SCIENTIST POSTDOCTORAL TRAINING
    Trenton Schoeb; Fiscal Year: 2006
    ..abstract_text> ..
  17. VOLATILE ANESTHETICS AND CARDIAC FUNCTION
    PHILIPPE HOUSMANS; Fiscal Year: 2001
    ..Moreover, these results might provide a rational basis of knowledge on which to formulate pharmacological action to reverse or prevent myocardial depression in surgical patients. ..
  18. Pain Assessment in Cognitively Impaired Children
    Shobha Malviya; Fiscal Year: 2005
    ..A reliable and valid pain assessment tool is critical to facilitate our future study of pain management strategies in these children. ..
  19. CHARACTERIZING PSYCHOACTIVE EFFECTS OF INHALANTS
    James Zacny; Fiscal Year: 2004
    ..In short, in our two proposed series of studies, we are developing a human laboratory model of inhalant abuse by studying potential determinants of abuse liability of inhalants (volatile and gaseous) in healthy volunteers. ..
  20. DOPAMINE AND PLASTICITY IN RESPIRATORY CONTROL
    Rebecca Johnson; Fiscal Year: 2002
    ..End of Abstract) ..
  21. VOLATILE ANESTHETICS IN PRESSURE OVERLOAD HYPERTROPHY
    James Hannon; Fiscal Year: 2002
    ....
  22. AGE RELATED CARDIAC SENSITIVITY TO VOLATILE ANESTHETICS
    Y S Prakash; Fiscal Year: 2001
    ....
  23. Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients
    James P Zacny; Fiscal Year: 2010
    ..g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients. ..