lactic acid

Summary

Summary: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)

Top Publications

  1. pmc Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    Pierre Sonveaux
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    J Clin Invest 118:3930-42. 2008
  2. ncbi PLGA-based nanoparticles: an overview of biomedical applications
    Fabienne Danhier
    Universite Catholique de Louvain, Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Avenue Mounier, B1 73 12, 1200 Brussels, Belgium
    J Control Release 161:505-22. 2012
  3. pmc Comparative genomics of the lactic acid bacteria
    K Makarova
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Proc Natl Acad Sci U S A 103:15611-6. 2006
  4. ncbi Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    Valeria R Fantin
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 9:425-34. 2006
  5. ncbi Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
    Anthony P Burgard
    Department of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biotechnol Bioeng 84:647-57. 2003
  6. pmc Astrocyte-neuron lactate transport is required for long-term memory formation
    Akinobu Suzuki
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cell 144:810-23. 2011
  7. ncbi Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Adv Drug Deliv Rev 55:329-47. 2003
  8. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
  9. pmc Lactate metabolism: a new paradigm for the third millennium
    L B Gladden
    Department of Health and Human Performance, 2050 Memorial Coliseum, Auburn University, Auburn, AL 36849 5323, USA
    J Physiol 558:5-30. 2004
  10. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011

Research Grants

  1. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    L Jeannine Brady; Fiscal Year: 2013
  2. Systemic Chemotherapy of Melanoma: NMR Studies of Lonidamine &N-Mustard Activity
    Jerry D Glickson; Fiscal Year: 2013
  3. Genetics and Genomics of the yidC paralogs in Streptococcus mutans
    SARA MARIE RASER PALMER; Fiscal Year: 2013
  4. Lactogenic immunity/probiotics: Effect on neonatal gut immunity
    Linda J Saif; Fiscal Year: 2010
  5. Molecular Epidemiology of the Vaginal Microbiome
    Rebecca M Brotman; Fiscal Year: 2013
  6. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
  7. PKM2 inhibition and redox regulation in chemoprevention
    Yunfeng Zhao; Fiscal Year: 2013
  8. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2010
  9. 1H NMR STUDIES OF NON-HODGKINS LYMPHOMA
    Jerry D Glickson; Fiscal Year: 2012
  10. Thiamine as a Metabolic Resuscitator in Septic Shock
    Michael William Donnino; Fiscal Year: 2012

Detail Information

Publications331 found, 100 shown here

  1. pmc Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    Pierre Sonveaux
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    J Clin Invest 118:3930-42. 2008
    ..Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient in the tumor...
  2. ncbi PLGA-based nanoparticles: an overview of biomedical applications
    Fabienne Danhier
    Universite Catholique de Louvain, Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Avenue Mounier, B1 73 12, 1200 Brussels, Belgium
    J Control Release 161:505-22. 2012
    ..This review focuses on the understanding of specific characteristics exploited by PLGA-based nanoparticles to target a specific organ or tissue or specific cells...
  3. pmc Comparative genomics of the lactic acid bacteria
    K Makarova
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Proc Natl Acad Sci U S A 103:15611-6. 2006
    b>Lactic acid-producing bacteria are associated with various plant and animal niches and play a key role in the production of fermented foods and beverages...
  4. ncbi Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    Valeria R Fantin
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 9:425-34. 2006
    ..These results demonstrate that LDH-A plays a key role in tumor maintenance...
  5. ncbi Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
    Anthony P Burgard
    Department of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biotechnol Bioeng 84:647-57. 2003
    ..Finally, the OptKnock procedure, by coupling biomass formation with chemical production, hints at a growth selection/adaptation system for indirectly evolving overproducing mutants...
  6. pmc Astrocyte-neuron lactate transport is required for long-term memory formation
    Akinobu Suzuki
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cell 144:810-23. 2011
    ..We conclude that astrocyte-neuron lactate transport is required for long-term memory formation...
  7. ncbi Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Adv Drug Deliv Rev 55:329-47. 2003
    ..Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed...
  8. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
    ..These findings provide further understanding for the possible therapeutic effects of curcumin and C-NPs in further pre-clinical and clinical research...
  9. pmc Lactate metabolism: a new paradigm for the third millennium
    L B Gladden
    Department of Health and Human Performance, 2050 Memorial Coliseum, Auburn University, Auburn, AL 36849 5323, USA
    J Physiol 558:5-30. 2004
    ....
  10. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011
    ..Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques...
  11. ncbi Bacteriocins from lactic acid bacteria: production, purification, and food applications
    Luc De Vuyst
    Department of Applied Biological Sciences and Engineering, Research Group of Industrial Microbiology and Food Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium
    J Mol Microbiol Biotechnol 13:194-9. 2007
    In fermented foods, lactic acid bacteria (LAB) display numerous antimicrobial activities. This is mainly due to the production of organic acids, but also of other compounds, such as bacteriocins and antifungal peptides...
  12. ncbi The effects of alternate optimal solutions in constraint-based genome-scale metabolic models
    R Mahadevan
    Genomatica, Inc, Bioprocessing Division, 5405 Morehouse Drive, Suite 210, San Diego, CA 92121, USA
    Metab Eng 5:264-76. 2003
    ..These methods also provide an efficient and robust method to calculate the range of flux distributions that can be derived from quantitative fermentation data...
  13. ncbi The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices
    R A Jain
    NanoSystems, a Division of Elan Pharmaceutical Technologies, King of Prussia, PA 19406, USA
    Biomaterials 21:2475-90. 2000
    ..Also, certain issues about other related biodegradable polyesters are discussed...
  14. ncbi Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis
    Suveera Dhup
    Pole of Pharmacology, Institute of Experimental and Clinical Research IREC, Universite catholique de Louvain UCL Medical School, Brussels, Belgium
    Curr Pharm Des 18:1319-30. 2012
    ..To fulfill tumor cell needs, the glycolytic switch is associated with elevated glucose uptake and lactic acid release...
  15. ncbi Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype
    Stacey L Demento
    Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
    Biomaterials 33:4957-64. 2012
    ..Thus, this study highlights the importance of sustained antigen release mediated by particulate platforms and its role in the long-term appearance of effector memory cellular response...
  16. pmc Current advances in research and clinical applications of PLGA-based nanotechnology
    Jian ming Lu
    Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Expert Rev Mol Diagn 9:325-41. 2009
    ....
  17. ncbi The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review
    Susanne Fredenberg
    Department of Chemical Engineering, Lund University, PO Box 124, SE 221 00 Lund, Sweden
    Int J Pharm 415:34-52. 2011
    ..Basic, generally applicable and mechanistic research provides pieces of the puzzle, which is useful in the development of controlled-release pharmaceuticals...
  18. pmc Regulation of oligodendrocyte development and myelination by glucose and lactate
    Johanne E Rinholm
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, UK
    J Neurosci 31:538-48. 2011
    ....
  19. ncbi Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells
    Olivier Feron
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    Radiother Oncol 92:329-33. 2009
    ..Combination with radiotherapy renders remaining cells more sensitive to irradiation, emphasizing how interference with tumor cell metabolism may complement current anticancer modalities...
  20. ncbi CD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo
    Christopher Schliehe
    Division of Immunology, Department of Biology, Constance University, 78457 Konstanz, Germany
    J Immunol 187:2112-21. 2011
    ..Moreover, immune responses in BATF3 knockout mice lacking CD8(+) DCs were normal. The results presented in this work strongly suggest that in vivo cross-priming of PLGA MS-encapsulated Ag is performed by CD8(-) DCs and MΦs...
  21. ncbi Probiotic lactic acid bacteria in the gastro-intestinal tract: health benefits, safety and mode of action
    L M T Dicks
    Department of Microbiology, University of Stellenbosch, South Africa
    Benef Microbes 1:11-29. 2010
    b>Lactic acid bacteria (LAB) have received considerable attention as probiotics over the past few years. This concept has grown from traditional dairy products to a profitable market of probiotic health supplements and functional foods...
  22. pmc Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product
    Sylvia H Duncan
    Microbial Genetics Group, Rowett Research Institute, Greenburn Rd, Bucksburn, Aberdeen AB21 9SB, UK
    Appl Environ Microbiol 70:5810-7. 2004
    The microbial community of the human colon contains many bacteria that produce lactic acid, but lactate is normally detected only at low concentrations (<5 mM) in feces from healthy individuals...
  23. pmc Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    Ubaldo E Martinez-Outschoorn
    Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:3256-76. 2010
    ..As such, the effects of stromal oxidative stress can be laterally propagated, amplified and are effectively "contagious"--spread from cell-to-cell like a virus--creating an "oncogenic/mutagenic" field promoting widespread DNA damage...
  24. ncbi Activity-dependent regulation of energy metabolism by astrocytes: an update
    Luc Pellerin
    Departement de Physiologie, Universite de Lausanne, Switzerland
    Glia 55:1251-62. 2007
    ....
  25. ncbi Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma
    Michael I Koukourakis
    Department of Radiotherapy Oncology, Democritus University of Thrace, PO Box 12, Alexandroupolis 68100, Greece
    Cancer Res 66:632-7. 2006
    ..Tumors survive and grow because they are capable of organizing the regional fibroblasts and endothelial cells into a harmoniously collaborating metabolic domain...
  26. pmc Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics
    Ubaldo E Martinez-Outschoorn
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1271-86. 2011
    ..Importantly, this powerful new approach directly links cancer cell metabolism with clinical outcome, and new therapeutic strategies for inhibiting the TCA cycle and mitochondrial oxidative phosphorylation in cancer cells...
  27. ncbi Characterization of nanoparticle uptake by endothelial cells
    Jasmine Davda
    Department of Pharmaceutical Sciences, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int J Pharm 233:51-9. 2002
    ..Nanoparticles localized in the endothelium could provide prolonged drug effects because of their sustained release characterics, and also could protect the encapsulated agent from enzymatic degradation...
  28. ncbi Lactate: a metabolic key player in cancer
    Franziska Hirschhaeuser
    Institute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Cancer Res 71:6921-5. 2011
    ..In summary, accumulation of lactate in solid tumors is a pivotal and early event in the development of malignancies. The determination of lactate should enter further clinical trials to confirm its relevance in cancer biology...
  29. ncbi Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel
    Fabienne Danhier
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier 73 20, 1200 Brussels, Belgium
    J Control Release 140:166-73. 2009
    ..Hence, the targeting of anti-cancer drug to tumor endothelium by RGD-labeled NP is a promising approach...
  30. ncbi Lactate as a pivotal element in neuron-glia metabolic cooperation
    Luc Pellerin
    Institut de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Neurochem Int 43:331-8. 2003
    ..Thus, lactate is emerging as a valuable intercellular exchange molecule in different systems including the brain where it might be an essential element of neuron-glia metabolic interactions...
  31. ncbi The expression of lactate transporters (MCT1 and MCT4) in heart and muscle
    A Bonen
    Department of Kinesiology, University of Waterloo, Ontario, Canada abonen healthy uwaterloo ca
    Eur J Appl Physiol 86:6-11. 2001
    ..Therefore, skeletal muscle lactate concentrations are not only regulated by the rate of glycolysis, but also by the efficiency of trans-sarcolemmal lactate transport, a process that is regulated by the quantity of available MCT proteins...
  32. ncbi The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    Mohammed S Ullah
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 281:9030-7. 2006
    The monocarboxylate transporter MCT4 mediates lactic acid efflux from most tissues that are dependent on glycolysis for their ATP production...
  33. ncbi Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
    Sanjeeb K Sahoo
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center 986025, Omaha, NE 68198 6025, USA
    J Control Release 82:105-14. 2002
    ..In conclusion, the residual PVA associated with nanoparticles is an important formulation parameter that can be used to modulate the pharmaceutical properties of PLGA nanoparticles...
  34. pmc In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    BMC Infect Dis 11:200. 2011
    ..Here we used conditions more like those in vivo to compare the effects of physiologically plausible concentrations of H2O2 and lactic acid on a broad range of BV-associated bacteria and vaginal lactobacilli.
  35. ncbi Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis
    Frederique Vegran
    Universite Catholique de Louvain, Pole of Pharmacology and Therapeutics UCL FATH, Angiogenesis and Cancer Research Laboratory, Institute of Experimental and Clinical Research IREC, Brussels, Belgium
    Cancer Res 71:2550-60. 2011
    ..In conclusion, our findings establish a signaling role for lactate in endothelial cells and they identify the lactate/NF-κB/IL-8 pathway as an important link between tumor metabolism and angiogenesis...
  36. ncbi Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy
    Sam E Day
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Nat Med 13:1382-7. 2007
    ..The technique could provide a new way to assess tumor responses to treatment in the clinic...
  37. ncbi PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect
    Sarbari Acharya
    Institute of Life Sciences, Nalco Square, Bhubaneswar, India
    Adv Drug Deliv Rev 63:170-83. 2011
    ..Ongoing research about drug-loaded nanoparticles and their delivery by the EPR effect to the tumour tissues has been elucidated in this review with clarity...
  38. ncbi Inhibitory effect of tumor cell-derived lactic acid on human T cells
    Karin Fischer
    Department of Hematology and Oncology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Blood 109:3812-9. 2007
    A characteristic feature of tumors is high production of lactic acid due to enhanced glycolysis...
  39. ncbi Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
    Jerry M Wells
    Host Microbe Interactomics, University of Wageningen, Animal Sciences Department, P O Box 338, 6700 AH, Wageningen, The Netherlands
    Nat Rev Microbiol 6:349-62. 2008
    Studies of lactic acid bacteria (LAB) as delivery vehicles have focused mainly on the development of mucosal vaccines, with much effort being devoted to the generation of genetic tools for antigen expression in different bacterial ..
  40. ncbi Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial
    Tim C Jansen
    Department of Intensive Care, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 182:752-61. 2010
    ..It is unknown whether lactate monitoring aimed to decrease levels during initial treatment in critically ill patients improves outcome...
  41. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    ..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
  42. ncbi Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
    Fabienne Danhier
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier, 73 20, 1200 Brussels, Belgium
    J Control Release 133:11-7. 2009
    ..Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
  43. pmc Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
    Che Ming J Hu
    Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:10980-5. 2011
    ..The translocation of natural cellular membranes, their associated proteins, and the corresponding functionalities to the surface of synthetic particles represents a unique approach in nanoparticle functionalization...
  44. pmc Phylogenomic reconstruction of lactic acid bacteria: an update
    Zhi Gang Zhang
    State Key Laboratory of Genetic Resources and Evolution, Laboratory of Evolutionary and Functional Genomics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China
    BMC Evol Biol 11:1. 2011
    b>Lactic acid bacteria (LAB) are important in the food industry for the production of fermented food products and in human health as commensals in the gut...
  45. pmc Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo
    Preetha Anand
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
    Biochem Pharmacol 79:330-8. 2010
    ..Overall we demonstrate that curcumin-loaded PLGA nanoparticles formulation has enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo over curcumin...
  46. pmc Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells
    Ubaldo E Martinez-Outschoorn
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cancer Biol Ther 12:924-38. 2011
    ..In this context, TIGAR may be a key "druggable" target for preventing drug resistance in cancer cells, as it protects cancer cells against the onset of stress-induced mitochondrial dys-function and aerobic glycolysis...
  47. ncbi In vivo evidence for lactate as a neuronal energy source
    Matthias T Wyss
    Institute of Pharmacology and Toxicology, University of Zurich, 8091 Zurich, Switzerland
    J Neurosci 31:7477-85. 2011
    ....
  48. pmc Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study
    Stephen O Crawford
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Int J Epidemiol 39:1647-55. 2010
    ..Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies...
  49. ncbi Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy
    Anindita Mukerjee
    Department of Molecular Biology, Institute for Cancer Research, Graduate School of Biomedical Sciences, University of North Texas, Health Science Center, Fort Worth, TX, 76107, USA
    Anticancer Res 29:3867-75. 2009
    ..Our present work investigated the efficiency of encapsulation of curcumin in poly (lactic-coglycolic acid) (PLGA) nanospheres using solid/oil/water emulsion solvent evaporation method...
  50. pmc Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells
    Timothy H Witney
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 286:24572-80. 2011
    ..The kinetic model should be useful for modeling the exchange reaction in vivo, particularly as this technique progresses to the clinic...
  51. pmc Brain metabolism dictates the polarity of astrocyte control over arterioles
    Grant R J Gordon
    Brain Research Centre, Department of Psychiatry, University of British Columbia, British Columbia T2N 2B5, Canada
    Nature 456:745-9. 2008
    ..These data reveal the role of metabolic substrates in regulating brain blood flow and provide a mechanism for differential astrocyte control over cerebrovascular diameter during different states of brain activation...
  52. pmc Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers
    Agnieszka K Witkiewicz
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:1108-17. 2012
    ....
  53. ncbi Controlled ring-opening polymerization of lactide and glycolide
    Odile Dechy-Cabaret
    Laboratoire Hétérochimie Fondamentale et Appliquée du CNRS UMR 5069, Universite Paul Sabatier, 118, route de Narbonne, 31062 Toulouse Cedex 04, France
    Chem Rev 104:6147-76. 2004
  54. ncbi Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells
    Murali Mohan Yallapu
    Cancer Biology Research Center, Sanford Research USD, Sioux Falls, SD 57105, USA
    J Colloid Interface Sci 351:19-29. 2010
    ....
  55. ncbi Three-dimensional fibrous PLGA/HAp composite scaffold for BMP-2 delivery
    Hemin Nie
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biotechnol Bioeng 99:223-34. 2008
    ..Cell culture experiments showed that the encapsulation of HAp could enhance cell attachment to scaffolds and lower cytotoxicity...
  56. pmc Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
    Fiona A Sharp
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 106:870-5. 2009
    ..Our data demonstrate that uptake of microparticulate adjuvants by DCs activates the NALP3 inflammasome, and this contributes to their enhancing effects on innate and antigen-specific cellular immunity...
  57. ncbi Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
    L Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Dev Neurosci 20:291-9. 1998
    ..This set of data is consistent with the existence of an activity-dependent astrocyte-neuron lactate shuttle for the supply of energy substrates to neurons...
  58. ncbi Yeast genes involved in response to lactic acid and acetic acid: acidic conditions caused by the organic acids in Saccharomyces cerevisiae cultures induce expression of intracellular metal metabolism genes regulated by Aft1p
    Miho Kawahata
    National Research Institute of Brewing, Kagamiyama, Higashi Hiroshima, Japan
    FEMS Yeast Res 6:924-36. 2006
    Using two types of genome-wide analysis to investigate yeast genes involved in response to lactic acid and acetic acid, we found that the acidic condition affects metal metabolism...
  59. ncbi Overview on sugar metabolism and its control in Lactococcus lactis - the input from in vivo NMR
    Ana Rute Neves
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Rua da Quinta Grande, 6, Apt 127, 2780 156 Oeiras, Portugal
    FEMS Microbiol Rev 29:531-54. 2005
    The wide application of lactic acid bacteria in the production of fermented foods depends to a great extent on the unique features of sugar metabolism in these organisms...
  60. ncbi Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    FASEB J 16:1217-26. 2002
    ..S. Food and Drug Administration. Hence PLGA is well suited for sustained intracellular delivery of macromolecules...
  61. ncbi PLA/PLGA nanoparticles for sustained release of docetaxel
    T Musumeci
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Catania, Viale A Doria 6, I 95125 Catania, Italy
    Int J Pharm 325:172-9. 2006
    ..Kinetic experiments demonstrated that the release process of DTX form nanospheres is affected by the molecular weight of the employed polymers...
  62. ncbi Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody
    Petra Kocbek
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, Ljubljana, Slovenia
    J Control Release 120:18-26. 2007
    ..Furthermore, the results show the effectiveness of the new carrier system for targeted delivery of small or large active substances into cells or tissues of interest...
  63. ncbi Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles
    Jayanth Panyam
    Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
    J Control Release 92:173-87. 2003
    ..1 microm) as compared to the larger-size microparticles could explain some of the observed degradation results with different size particles...
  64. ncbi PLA nano- and microparticles for drug delivery: an overview of the methods of preparation
    Verónica Lassalle
    PLAPIQUI UNS CONICET, Planta Piloto de Ingeniería Química, Camino La Carrindanga Km 7, CC 717 8000 Bahía Blanca, Prov Buenos Aires, Argentina
    Macromol Biosci 7:767-83. 2007
    ..Furthermore, certain issues involved in the addition of other monomeric substrates than lactic acid to the particles formulation as well as novel devices, other than nano- and microparticles, will be discussed ..
  65. pmc pH-, Lactic acid-, and non-lactic acid-dependent activities of probiotic Lactobacilli against Salmonella enterica Serovar Typhimurium
    Domitille Fayol-Messaoudi
    Faculte de Pharmacie, Inserm Unité 510, F 92296 Chatenay Malabry, France
    Appl Environ Microbiol 71:6008-13. 2005
    ..Lactobacillus strains appears to be multifactorial and includes lowering of the pH and the production of lactic acid and of antibacterial compounds, including bacteriocins and nonbacteriocin, non-lactic acid molecules...
  66. pmc Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells
    Alessia Lodi
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158 2512, USA
    NMR Biomed 26:299-306. 2013
    ..Our findings highlight the complexity of interactions between MEK and metabolism, and the need for mechanistic validation before hyperpolarized ¹³C MRS can be used to monitor treatment-induced molecular responses...
  67. pmc Tumor metabolism: cancer cells give and take lactate
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, Department of Pediatrics, John Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 118:3835-7. 2008
    ..MCT1 expression was detected exclusively in nonhypoxic regions of human cancer biopsy samples, and in combination, these data suggest that MCT1 inhibition holds potential as a novel cancer therapy...
  68. ncbi Adipose-derived adult stromal cells heal critical-size mouse calvarial defects
    Catherine M Cowan
    The Department of Surgery, Stanford University School of Medicine, Stanford University, 257 Campus Drive, Stanford, California 94305, USA
    Nat Biotechnol 22:560-7. 2004
    ..The contribution of implanted cells to new bone formation was 84-99% by chromosomal detection. These data show that ADAS cells heal critical-size skeletal defects without genetic manipulation or the addition of exogenous growth factors...
  69. ncbi Lactate: mirror and motor of tumor malignancy
    Stefan Walenta
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Semin Radiat Oncol 14:267-74. 2004
    ..We propose that determination of lactate in primary tumors may serve as a basis of a novel metabolic classification, which can lead to an improvement of prognosis and therapy in clinical oncology...
  70. ncbi Stabilization and encapsulation of recombinant human erythropoietin into PLGA microspheres using human serum albumin as a stabilizer
    Jintian He
    Hebei Normal University, Hebei Province, People s Republic of China he
    Int J Pharm 416:69-76. 2011
    ..The results suggested that the integrity of rhEPO was successfully protected during the encapsulation process and the release period from polymeric matrices...
  71. pmc Complete genome sequence of Lactococcus lactis IO-1, a lactic acid bacterium that utilizes xylose and produces high levels of L-lactic acid
    Hiroaki Kato
    Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan
    J Bacteriol 194:2102-3. 2012
    We report the complete genome sequence of Lactococcus lactis IO-1 (= JCM7638). It is a nondairy lactic acid bacterium, produces nisin Z, ferments xylose, and produces predominantly L-lactic acid at high xylose concentrations...
  72. ncbi Long-Term (>10 Years) clinical outcomes of first-in-human biodegradable poly-l-lactic acid coronary stents: Igaki-Tamai stents
    Soji Nishio
    Department of Cardiology, Shiga Medical Center for Adults, 5 4 30, Moriyama, Moriyama City, Shiga, 524 8524 Japan
    Circulation 125:2343-53. 2012
    The purpose of this study was to evaluate the long-term safety of the Igaki-Tamai stent, the first-in-human fully biodegradable coronary stent made of poly-l-lactic acid.
  73. pmc Sweet sixteen for ANLS
    Luc Pellerin
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 32:1152-66. 2012
    ..The ANLS model now represents a useful, experimentally based framework to better understand the coupling between neuronal activity and energetics as it relates to neuronal plasticity, neurodegeneration, and functional brain imaging...
  74. pmc Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
    Nihed Draoui
    Universite Catholique de Louvain, Pole of Pharmacology and Therapeutics, Angiogenesis and Cancer Research Laboratory, Brussels, Belgium
    Dis Model Mech 4:727-32. 2011
    ..Translating knowledge of lactate shuttles to the cancer field offers new perspectives to therapeutically target the hypoxic tumor microenvironment and to tackle tumor angiogenesis...
  75. pmc Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR
    Crystal Harrison
    Department of Physics, University of Texas at Dallas, Richardson, TX 75390, USA
    NMR Biomed 25:1286-94. 2012
    ..The three-pool model was necessary to fit the combined data from both MS and HP, but the simpler two-pool exchange model was sufficient to determine the (13) C lactate concentration when the lactate appearance was measured only by HP...
  76. pmc PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses
    Wenxue Ma
    Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    Int J Nanomedicine 7:1475-87. 2012
    ..These results demonstrate that the delivery of peptides encapsulated in PLGA-NPs is a promising approach to induce effective antitumor CTL responses in vivo...
  77. pmc Engineering a cyanobacterial cell factory for production of lactic acid
    S Andreas Angermayr
    Swammerdam Institute for Life Sciences and Netherlands Institute for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands
    Appl Environ Microbiol 78:7098-106. 2012
    ..strain PCC6803 leads to l-lactic acid production, a phenotype which is shown to be stable for prolonged batch culturing...
  78. ncbi Important role of muscle carnosine in rowing performance
    Audrey Baguet
    Dept of Movement and Sports Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
    J Appl Physiol (1985) 109:1096-101. 2010
    ....
  79. ncbi Beta-alanine improves sprint performance in endurance cycling
    Ruud Van Thienen
    Department of Biomedical Kinesiology, Research Centre for Exercise and Health, Katholieke Universiteit Leuven, Leuven, Belgium
    Med Sci Sports Exerc 41:898-903. 2009
    ..Therefore, we investigated the effect of 8-wk betaALA administration in moderately to well-trained cyclists on sprint performance at the end of a simulated endurance cycling race...
  80. ncbi Review article: probiotics for the treatment of irritable bowel syndrome--focus on lactic acid bacteria
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 35:403-13. 2012
    ..The withdrawal, due to adverse events, of a number of pharmacological agents that were approved for the treatment of IBS has left a therapeutic vacuum for patients suffering from the disorder...
  81. ncbi Serum lactate as a predictor of mortality in emergency department patients with infection
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Emerg Med 45:524-8. 2005
    ..We determine whether a serum venous lactate is associated with an increased risk of death in ED patients with infection...
  82. pmc Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis
    Pierre Sonveaux
    Pole of Pharmacology, Institute of Experimental and Clinical Research, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 7:e33418. 2012
    ....
  83. ncbi Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents
    Romila Manchanda
    Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA
    Colloids Surf B Biointerfaces 75:260-7. 2010
    ..022+/-0.001%, w/w, for DOX (n=3). The release pattern was biphasic. ICG and DOX loaded-nanoparticle preparation was standardized based on the following parameters: PLGA concentration, PVA concentration and initial drug content...
  84. ncbi Food phenolics and lactic acid bacteria
    Hector Rodriguez
    Departamento de Microbiologia, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
    Int J Food Microbiol 132:79-90. 2009
    ..b>Lactic acid bacteria (LAB) are autochthonous microbiota of raw vegetables...
  85. pmc Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
    R Dinarvand
    Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Int J Nanomedicine 6:877-95. 2011
    ....
  86. ncbi Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle
    L H Bergersen
    Centre for Molecular Biology and Neuroscience, and Department of Anatomy, IBM, University of Oslo, Domus Medica, Room 1293, Songsvannsveien 9, POB 1105 Blindern, N 0317 Oslo, Norway
    Neuroscience 145:11-9. 2007
    ..This conclusion is based on studies in rodents using high resolution immunocytochemical methods at the light and electron microscopical levels...
  87. ncbi Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study
    Danilo T Noritomi
    Intensive Care Unit, Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil
    Crit Care Med 37:2733-9. 2009
    ..To describe the composition of metabolic acidosis in patients with severe sepsis and septic shock at intensive care unit admission and throughout the first 5 days of intensive care unit stay...
  88. pmc Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study
    Alistair D Nichol
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital Campus, 75 Commercial Road, Prahran, VIC 31821, Australia
    Crit Care 14:R25. 2010
    ..We tested the hypothesis that relative hyperlactatemia is independently associated with an increased risk of hospital death...
  89. ncbi Lactate: the ultimate cerebral oxidative energy substrate?
    Avital Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cereb Blood Flow Metab 26:142-52. 2006
    ..Concomitantly, it could satisfy both 'glucoseniks' and 'lactatians' in the ongoing debate...
  90. ncbi Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    Khin Yin Win
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 26:2713-22. 2005
    ..It is highly feasible for nanoparticles of biodegradable polymers to be applied to promote oral chemotherapy...
  91. ncbi Effect of acidic pH on PLGA microsphere degradation and release
    Banu S Zolnik
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States
    J Control Release 122:338-44. 2007
    ..4. This is the first time that morphological changes during PLGA microsphere degradation have been compared for low and neutral pH and the data shows a change in the mechanism of degradation at the low pH...
  92. ncbi Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats
    K Sonaje
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, SAS Nagar, Mohali, Punjab, 160062, India
    Pharm Res 24:899-908. 2007
    ..Ellagic acid (EA), a dietary antioxidant associated with poor biopharmaceutical properties, was encapsulated into poly(lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) nanoparticles to improve oral bioavailability...
  93. ncbi Coupling of biotin-(poly(ethylene glycol))amine to poly(D,L-lactide-co-glycolide) nanoparticles for versatile surface modification
    Barbara Weiss
    Biopharmaceutics and Pharmaceutical Technology, Center for Bioinformatics, Saarland University, Saarbruecken, Germany
    Bioconjug Chem 18:1087-94. 2007
    ..Furthermore, after coupling of NAv-linked fluorescence dyes to BPEG-functionalized NP, differences in binding and uptake could be demonstrated using two epithelial cell lines (Caco-2, A549)...
  94. ncbi Design of estradiol loaded PLGA nanoparticulate formulations: a potential oral delivery system for hormone therapy
    S Hariharan
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, 160062, Punjab, India
    Pharm Res 23:184-95. 2006
    ..Histopathological examination and blood counts indicated the absence of inflammatory response. These data suggest that DMAB stabilized PLGA nanoparticles have great potential as carriers for oral delivery of estradiol...
  95. ncbi Biodegradable nanoparticle mediated antigen delivery to human cord blood derived dendritic cells for induction of primary T cell responses
    Manish Diwan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    J Drug Target 11:495-507. 2003
    ..0005). These results indicate that PLGA nanoparticles mimicking certain features of pathogens are efficient delivery systems for targeting vaccine antigens to DCs and activation of potent T cell responses...
  96. pmc Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
    Frank Gu
    Department of Chemical Engineering, Harvard MIT Center of Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:2586-91. 2008
    ..This approach may contribute to further development of targeted NPs as highly selective and effective therapeutic modalities...
  97. ncbi Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198 6025, USA
    Pharm Res 20:212-20. 2003
    ..The purpose of this work was to characterize the process of endocytosis, exocytosis, and intracellular retention of poly (D,L-lactide-co-glycolide) nanoparticles in vitro using human arterial vascular smooth muscle cells (VSMCs)...
  98. ncbi Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives
    Raghavendra C Mundargi
    Industrial Biotechnology Group, Reliance Life Sciences Pvt Ltd, Dhirubhai Ambani Life Sciences Centre, Thane Belapur Road, Rabale, Navi Mumbai 400 701, India
    J Control Release 125:193-209. 2008
    ..The present review attempts to address some important data on nano/microparticle-based delivery systems of PLGA and PLGA-derived polymers with reference to macromolecular drugs...
  99. ncbi The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity
    Fei Yan
    The Shenzhen Key Laboratory of Gene and Antibody Therapy, Center for Biotech and Bio Medicine and Division of Life Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen, People s Republic of China
    Nanomedicine 6:170-8. 2010
    ....
  100. ncbi Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition
    Guixia Ling
    School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
    J Control Release 148:241-8. 2010
    ..The new DPNs might provide an effective strategy for oral delivery of VCR with improved encapsulation efficiency and oral bioavailability...
  101. pmc Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: impact on growth and osteogenic differentiation of human mesenchymal stem cells
    Markus D Schofer
    Department of Orthopedics, University Hospital of Marburg, Baldingerstraße, 35043 Marburg, Germany
    J Mater Sci Mater Med 22:1753-62. 2011
    ..Therefore these different strategies can be combined in order to enhance the osteoblast differentiation of hMSC on PLLA based nanofiber scaffold. By doing this, different signal transduction pathways seem to be up regulated...

Research Grants63

  1. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    L Jeannine Brady; Fiscal Year: 2013
    ..A major virulence factor is demineralization of teeth by generation of lactic acid from dietary carbohydrates and bacterial tolerance of the acid products...
  2. Systemic Chemotherapy of Melanoma: NMR Studies of Lonidamine &N-Mustard Activity
    Jerry D Glickson; Fiscal Year: 2013
    ..to coadminister glucose with the monocarboxylic acid transport (MCT) inhibitor lonidamine LND in order to trap lactic acid produced by glycolysis in the tumor and to inhibit oxidative metabolism by impeding pyruvate trans- port into ..
  3. Genetics and Genomics of the yidC paralogs in Streptococcus mutans
    SARA MARIE RASER PALMER; Fiscal Year: 2013
    ..Additionally, there is strong evidence that yidC1 and yidC2 are differentially regulated in lactic acid bacteria. In a recent collaborative effort, we sequenced and analyzed the genomes of 57 clinical isolates of S...
  4. Lactogenic immunity/probiotics: Effect on neonatal gut immunity
    Linda J Saif; Fiscal Year: 2010
    ..Although lactic acid bacteria (LAB) reduce RV diarrhea in infants, mechanisms are undefined and the effect of providing concurrent ..
  5. Molecular Epidemiology of the Vaginal Microbiome
    Rebecca M Brotman; Fiscal Year: 2013
    ..bacterial communities in the vagina and their hosts can lead to bacterial vaginosis (BV), a condition in which lactic acid-producing bacteria are supplanted by a diverse array of strictly anaerobic bacteria...
  6. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    ..Dental caries is initiated by increased prevalence of mutans streptococci, which metabolize sucrose to lactic acid and create an acidic local environment that demineralizes tooth enamel and causes tooth decay...
  7. PKM2 inhibition and redox regulation in chemoprevention
    Yunfeng Zhao; Fiscal Year: 2013
    ..and co-workers that cancer cells, in the presence of oxygen, utilize high rates of glycolysis followed by lactic acid fermentation to produce energy. This biological process was coined the "Warburg Effect...
  8. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2010
    ..One multiorganism probiotic, VSL#3 contains 8 lactic acid bacteria, including Bifidobacterium and Lactobacillus species, which have synergistic properties for ..
  9. 1H NMR STUDIES OF NON-HODGKINS LYMPHOMA
    Jerry D Glickson; Fiscal Year: 2012
    ..objectives of the current proposal are 1) to define the mechanisms underlying therapy associated decreases in lactic acid, 2) to define the mechanism leading to MRI-detected regional response of the tumor, and 3) to extend the study ..
  10. Thiamine as a Metabolic Resuscitator in Septic Shock
    Michael William Donnino; Fiscal Year: 2012
    ..Thiamine (vitamin B1) is an essential component of cellular metabolism without which lactic acid build-up, low blood pressure, and death will ultimately occur...
  11. Biodegradable Polymeric Nanosphere Drug Delivery System For Cancer Chemotherapy
    Emmanuel O Akala; Fiscal Year: 2010
    ..nanoparticles by developing paclitaxel-loaded stealth nanospheres based on biocompatible and biodegradable poly(lactic acid)...
  12. The Microbial Ecology of Bacterial Vaginosis: A Fine Scale Resolution Metagenomic
    Jacques Ravel; Fiscal Year: 2011
    ..bacterial communities in the vagina and their hosts can lead to bacterial vaginosis (BV), a condition in which lactic acid producing bacteria are supplanted by a diverse array of strictly anaerobic bacteria...
  13. Vaginal Ring for Preventing Bacterial Vaginosis
    THOMAS RAY MOENCH; Fiscal Year: 2010
    ..Healthy vaginal lactobacilli continuously produce lactic acid at a rate that acidifies the vagina to pH~4...
  14. Luminescent Oxygen Nanosensors for Tumor Hypoxia Imaging
    Cassandra L Fraser; Fiscal Year: 2013
    ..cancer biology, the objective of this application is to develop dualemissive difluoroboron ?-diketonate-poly(lactic acid) (BF2bdkPLA) dye-polymer nanoparticles (BNPs) in conjunction with imaging methodologies for luminescence ..
  15. Modulation of Monocarboxylic Acid Transporter Kinetic Function for Stroke Therapy
    JEFFREY PAUL SMITH; Fiscal Year: 2010
    ..This work is significant because cerebrovascular endothelial cell MCT1 is the sole facilitator of lactic acid transport across the blood brain barrier's cerebrovascular endothelium...
  16. Genes and Neural Circuits Mediating Avoidance Behavior
    Greg S B Suh; Fiscal Year: 2013
    ..Many insects respond to their human and animal hosts primarily through carbon dioxide (CO2) and lactic acid, key olfactory cues emanating from mammals...
  17. Duet cervical barrier device for maximizing protective efficacy of microbicides
    Richard Cone; Fiscal Year: 2009
    ..To test this hypothesis: (a) Measure in vitro the speed at which lactic acid and acetic acid at vaginal pH (~4) inactivate sexually transmitted pathogens, BV-associated microbes, and sperm,..
  18. Lactobacilli as a source of natural microbicides against HIV-1
    RUTH INGRID CONNOR; Fiscal Year: 2011
    ..Under anaerobic conditions, these bacteria produce lactic acid and certain strains also produce hydrogen peroxide, a potent antimicrobial that has been shown to inactivate ..
  19. Metabolite effects on Group III and IV afferents
    MARC PETER KAUFMAN; Fiscal Year: 2013
    ..Three putative] metabolic stimuli will be investigated, namely lactic acid, ATP, a purine which stimulates P2 receptors, and bradykinin, a peptide that stimulates B2 receptors...
  20. The Physiology of Oxidative Stress in Escherichia coli
    James A Imlay; Fiscal Year: 2013
    ..abstract_text> ..
  21. DISPERSION OF STREPTOCOCCUS MUTANS BIOFILMS BY A NOVEL SMALL MOLECULE
    SANDRA S GARCIA; Fiscal Year: 2013
    ..Not only can S. mutans form biofilms readily on the tooth surface, but this bacterium rapidly produces lactic acid from dietary sugars...
  22. Proton Sponge Adhesives, Interfacial Milieu: Molecular Structure-Mechanics
    Paulette Spencer; Fiscal Year: 2013
    ..mutans attachment, reaction to lactic acid, mechanical properties) and to optimize features for in situ adhesive/dentin bond formation based on kinetics, ..
  23. Recombinant Lactobacillus as an Oral Mucosal Vaccine Against HIV-1
    Gregg A Dean; Fiscal Year: 2012
    ..b>Lactic acid bacteria have been used for centuries to process and preserve food and are well known for their probiotic ..
  24. Stable isotopic and metabolomic studies in a model of lactic acidosis tolerance
    Daniel E Warren; Fiscal Year: 2012
    ..species known, has metabolic rates an order of magnitude lower than a similar sized mammal, and can accumulate lactic acid to concentrations 4-5x greater than the lethal limit for mammals...
  25. REGULATION OF PHI AND FLUID FLUX IN CORNEAL ENDOTHELIUM
    JOSEPH AURELIO BONANNO; Fiscal Year: 2013
    ..Because the cornea is very glycolytic and must remove the end product, which is lactic acid, we propose that the transcellular flux of lactate is coupled to water movement;that lactate flux is via ..
  26. Engineered Regeneration of Bone through a Small Molecule Cyclic Adenosine Monopho
    Cato T Laurencin; Fiscal Year: 2012
    ..6-Bnz-cAMP), promotes initial cell adhesion and supports proliferation on biodegradable polymeric poly(lactic acid-co-glycolic acid) scaffolds...
  27. Gene expression programs of lactic acidosis in human cancers
    Jen Tsan Ashley Chi; Fiscal Year: 2013
    ..Robust aerobic glycolysis and significant perfusion defects cause an accumulation of lactic acid, termed lactic acidosis, in many solid human tumors...
  28. Signal Transduction in Intrapulmonary Chemoreceptors
    Steven C Hempleman; Fiscal Year: 2010
    ..Aim II will test whether transient lactic acid accumulation or KATP channels play roles in IPC spike frequency adaptation (SFA), using lactate infusion and ..
  29. Effects of Cannabinoids on Pain-Stimulated and Pain-Depressed Behavior in Rats
    Andrew J Kwilasz; Fiscal Year: 2013
    ..for intracranial self-stimulation (ICSS) is depressed following delivery of an intraperitoneal injection of lactic acid and this pain-induced depression of ICSS is blocked by classic analgesics...
  30. Genetic elements of cancer cell survival in tumor microenvironment stresses
    MELISSA M KEENAN; Fiscal Year: 2013
    ..These changes include low oxygen levels (hypoxia) and an accumulation of lactic acid with concomitant lowered pH levels (lactic acidosis)...
  31. Engineering Bimodal Degrading Hydrogels
    Franck Vernerey; Fiscal Year: 2012
    ..e., aggrecanses secreted by entrapped chondrocytes) or hydrolytically (i.e., poly(lactic acid) segments)...
  32. GCx(py)GCC-IRMS for Isotope Metabolomics
    JAMES T BRENNA; Fiscal Year: 2013
    ..of 13C and ?2H in labeled acetate, lactate, and PUFA to understand the kinetics of 13C flux among fatty acids;lactic acid ?13C and ?D in existing human samples will also be used to test the hypothesis that this molecule exhibits ..
  33. Imaging and Targeting Metastatic-Prone Breast Cancer
    JASON ARTHUR KOUTCHER; Fiscal Year: 2013
    ..This application focuses on the impact of changes in lactic acid metabolism on disease evolution, progression and development of metastases...
  34. Lactic acid transport across the corneal endothelium
    TRACY THUY NGUYEN; Fiscal Year: 2013
    ..The cornea is a very glycolytic tissue and therefore produces large amounts of lactic acid. This proposal will investigate the general hypothesjs that bicarbonate transporters of the corneal endothelial ..
  35. Pathogen trapping by genital mucus secretions
    JUSTIN S HANES; Fiscal Year: 2013
    ..Aim 3 will investigate the roles of lactic acid, and lactate anions, in causing STD pathogens to be trapped by mucus...
  36. MECHANISMS INVOLVED IN FLAVIN-LINKED OXYGEN METABOLISM
    Al Claiborne; Fiscal Year: 2005
    DESCRIPTION: (provided by applicant) Lactic acid bacteria are known to represent strong paradigms for the biochemical diversity in oxygen metabolism, due to their lack of respiratory cytochromes and other hemeproteins...
  37. Natural antimicrobials against bacterial vaginosis
    Michael Chikindas; Fiscal Year: 2006
    ..160 has increased bactericidal activity against vaginal pathogens at low pH established specifically by lactic acid and when combined with synergistically acting natural and safe antimicrobials such as Zn lactate, saponin, and ..
  38. OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBIN
    Robert Winslow; Fiscal Year: 2002
    ..Arterial lactic acid and acid-base status provides additional indicators of the balance between O2 supply and demand...
  39. Mechanisms regulating episodic breaches of protective vaginal microbiome by BV
    Ying Ying Wang; Fiscal Year: 2013
    ..by applicant): In women with a healthy vaginal microbiome, lactobacillus communities acidify the vagina with lactic acid, a potent and broad-spectrum microbicide that reinforces the mucosal barrier to sexually transmitted infections ..
  40. The Physiological Role of Carbonic Acid and Lactic Acid as Protonating Agents of
    Ehud Pines; Fiscal Year: 2013
    ..rate of acid-base proton transfer and application of this fundamentally important understanding to carbonic and lactic acid chemistry in blood plasma...
  41. PEROXIDASE IN SALIVA AND PREVENTION OF ORAL DISEASE
    EDWIN THOMAS; Fiscal Year: 1992
    ..The goal of the project is to achieve a greater understanding of the role of oxidizing agents in oral health and disease...
  42. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2009
    ..One multiorganism probiotic, VSL#3 contains 8 lactic acid bacteria, including Bifidobacterium and Lactobacillus species, which have synergistic properties for ..
  43. Role of novel pH-sensing receptor TDAG8 in panic
    Renu Sah; Fiscal Year: 2009
    ..Consistently, panic disorder patients show an exaggerated lactic acid response to hyperventilation and sodium lactate infusion leading to extreme fear and panic...
  44. Targeting gp41 to elicit neutralizing antibodies against HIV-1
    Michael W Cho; Fiscal Year: 2009
    ..we propose to target the membrane-proximal external region (MPER) of gp41 by generating recombinant lactic acid bacteria (LAB) that express antigenically intact gp41 protein fragments on the cell surface using a novel ..
  45. Technology for automated real-time counting and identification of adult mosquitoe
    PHILIPP KIRSCH; Fiscal Year: 2007
    ..control programs currently utilize trapping technology that targets adult host seeking behaviour (CO2, octenol, lactic acid etc. baited traps, with or without light) or adult oviposition behaviour (Culex gravid traps, Aedes ovitraps)...
  46. HYPERAMMONEMIA AND CANCER ANOREXIA
    WILLIAM CHANCE; Fiscal Year: 1990
    ..The major products of tumor metabolism appear to be lactic acid and ammonia...
  47. MECHANISM OF ACTION OF FIRE ANT VENOM
    NANCY LIND; Fiscal Year: 1980
    ..Histamine and lactic acid dehydrogenase (LDH) a cytoplasmic enzyme, are released concurrently, indicating disruption of the plasma ..
  48. RECYCLING DEFECTS OF COVALENTLY-BOUND VITAMINS
    Barry Wolf; Fiscal Year: 1991
    ..result in lactic acidosis, a primary defect in lipoamidase may be responsible for some unexplained disorders of lactic acid metabolism...
  49. ADHERENCE FACTORS OF ORAL STREPTOCOCCI
    RONALD DOYLE; Fiscal Year: 1993
    ..2) To study the inhibition of the GBL by fluoride and chelating agents, including lactic acid. 3) To study how manganous ion regulates GBL activity in S. sobrinus and other oral streptococci ...
  50. Stress and Neuroimmune Dysergulation in Chronic Fatigue Patients
    Kathleen Light; Fiscal Year: 2007
    ..reinforces the potential importance of ATP and recently identified sodium channels that respond to ATP and lactic acid in post- exertional fatigue and muscle pain (Acid Sensing Inward Current or ASIC3, P2X5 and TRPV1 receptors)...
  51. The presence of a bacterial metabolic pathway in eukaryotic fungi
    KERRY SCOT SMITH; Fiscal Year: 2010
    ..been proposed to form part of a modified pentose phosphoketolase pathway in the heterofermentative growth of lactic acid bacteria and play a key role in energy generation, but the role of this pathway in fungi has not yet been ..
  52. Brain Lactate and Photic Stimulation in Panic Disorder
    RICHARD MADDOCK; Fiscal Year: 2005
    ..Among the observations supporting this theory are the consistent findings of increased lactic acid responses to a variety of metabolic challenges in patients with panic disorder (reviewed in Maddock 2001)...
  53. CORNEAL METABOLIC ACTIVITY IN HUMANS
    Joseph Bonanno; Fiscal Year: 2002
    ..individuals should have a greater dependence on glycolytic metabolism, which will lead to greater production of lactic acid. Thus, the hypothesis also predicts that individuals with high Qc will show the greatest drop in corneal pH...
  54. RIBONUCLEOSIDES FOR PREDICTION OF SKIN IRRITATION
    WILLIAM REIFENRATH; Fiscal Year: 1999
    ..skin was assays for lactate production as an indicator of the main energy- producing pathways, for the enzyme lactic acid dehydrogenase (LDH) as an indicator of cell lysis, for color changes in a redox dye to indicate alteration in ..
  55. AROMATIC AMINO ACID CATABOLISM DURING TRYPANOSOMIASIS
    John Seed; Fiscal Year: 1980
    ..in urinary excretion of phenylpyruvic acid, 4-hydroxyphenylpyruvic acid, indole-3-pyruvic acid, indole-3-lactic acid and indole-3-acetic acid concurrent with large decreases in serum concentrations of tryptophan and tyrosine...
  56. Targeting gp41 to elicit neutralizing antibodies against HIV-1
    Michael W Cho; Fiscal Year: 2012
    ..we propose to target the membrane-proximal external region (MPER) of gp41 by generating recombinant lactic acid bacteria (LAB) that express antigenically intact gp41 protein fragments on the cell surface using a novel ..
  57. Global Mechanisms of Bacteriocin Resistance in Listeria
    Kurt Miller; Fiscal Year: 2007
    ..These peptides are produced by a number of beneficial lactic acid bacterial species that are used in food production. However, as with all antimicrobial agents, L...
  58. Use of symbiotics to reduce urinary oxalate excretion
    JOHN LIESKE; Fiscal Year: 2007
    ..A recent preliminary study demonstrated that a preparation of lactic acid bacteria degraded oxalate in vitro and reduced urinary oxalate excretion when given by mouth...
  59. S MUTANTS GLG GENE EXPRESSION
    Grace Spatafora; Fiscal Year: 2001
    ..caries formation is the metabolism of exogenous dietary carbohydrates; this results in the production of lactic acid in the oral cavity which leads to the demineralization of tooth enamel and the onset of dental decay...
  60. CEREBRAL BLOOD FLOW AND METABOLISM IN MENINGITIS
    JAY TUREEN; Fiscal Year: 1991
    ..autoregulation, alteration in metabolic processes in the brain including glucose utilization and lactic acid production, and the factors relating to development of intracranial hypertension...
  61. NMR STUDY OF BRAIN FUNCTION AND METABOLISM IN ANESTHESIA
    Alice Wyrwicz; Fiscal Year: 1999
    ..Changes in glutamate, glutamine, gamma-aminobutyric acid and lactic acid levels will be mapped using water-suppressed, ISIS-2D CSI spin-echo 1H spectroscopy...
  62. MECHANISMS AND TREATMENT OF CEREBRAL ISCHEMIA
    RUTH DIMLICH; Fiscal Year: 1992
    ..Cerebral ischemia results in an increase in lactic acid that has been linked to the production of irreversible changes in brain cell structure and function, especially ..
  63. BMP-2 Releasing Implant Surface for Bone Regeneration
    RAJIV SATSANGI; Fiscal Year: 2003
    ..atom chains having the same monomeric functionalities as that of a few biodegradable polymers, such as poly-lactic acid, poly-glycolic acid, poly-hydroxy butyrate, so that the linker may retain the property of biodegardation, yet ..