sodium oxybate

Summary

Summary: The sodium salt of 4-hydroxybutyric acid. Anesthetic used for both induction and maintenance. It may cause bradycardia and dyskinesias.

Top Publications

  1. ncbi [Is GHB use in Switzerland on the rise?]
    H R Pfeifer
    Forschungsgruppe Substanzstörungen, Psychiatrische Universitätsklinik Zürich
    Praxis (Bern 1994) 93:1247-9. 2004
  2. ncbi High mortality rates among GHB abusers in Western Sweden
    Kai Knudsen
    Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Toxicol (Phila) 46:187-92. 2008
  3. ncbi GHB depresses fast excitatory and inhibitory synaptic transmission via GABA(B) receptors in mouse neocortical neurons
    K Jensen
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Cereb Cortex 11:424-9. 2001
  4. ncbi Off-label treatment of severe childhood narcolepsy-cataplexy with sodium oxybate
    Hema Murali
    Division of Child Neurology, Sleep Disorders Center, Mayo Clinic, Rochester, MN 55902, USA
    Sleep 29:1025-9. 2006
  5. pmc Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex
    Q Li
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Neuroscience 150:82-92. 2007
  6. pmc Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid
    Melanie A Felmlee
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Amherst, New York, USA
    J Pharmacol Exp Ther 333:764-71. 2010
  7. ncbi Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain
    Petrine Wellendorph
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
    J Pharmacol Exp Ther 315:346-51. 2005
  8. ncbi gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors
    Paul Schweitzer
    The Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 311:172-9. 2004
  9. ncbi Presynaptic modulation of spontaneous inhibitory postsynaptic currents by gamma-hydroxybutyrate in the substantia nigra pars compacta
    Alfredo Brancucci
    Dipartimento di Fisiologia e Biochimica G Moruzzi, Universita di Pisa, Pisa, Italy
    Neuropsychopharmacology 29:537-43. 2004
  10. pmc Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory
    Julie Vienne
    Center for Integrative Genomics CIG, University of Lausanne, Lausanne, Switzerland
    Sleep 35:1071-83. 2012

Detail Information

Publications216 found, 100 shown here

  1. ncbi [Is GHB use in Switzerland on the rise?]
    H R Pfeifer
    Forschungsgruppe Substanzstörungen, Psychiatrische Universitätsklinik Zürich
    Praxis (Bern 1994) 93:1247-9. 2004
  2. ncbi High mortality rates among GHB abusers in Western Sweden
    Kai Knudsen
    Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Toxicol (Phila) 46:187-92. 2008
    ..GHB is a drug of abuse and acute poisonings have been an increasing medical problem over the last decade in Sweden...
  3. ncbi GHB depresses fast excitatory and inhibitory synaptic transmission via GABA(B) receptors in mouse neocortical neurons
    K Jensen
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Cereb Cortex 11:424-9. 2001
    ..We propose that GABA(B)-receptor antagonists may be useful in the treatment of acute GHB intoxication...
  4. ncbi Off-label treatment of severe childhood narcolepsy-cataplexy with sodium oxybate
    Hema Murali
    Division of Child Neurology, Sleep Disorders Center, Mayo Clinic, Rochester, MN 55902, USA
    Sleep 29:1025-9. 2006
    To evaluate the efficacy and side-effect profile of off-label sodium oxybate (gamma hydroxy butyrate) therapy in severe childhood narcolepsy-cataplexy.
  5. pmc Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex
    Q Li
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Neuroscience 150:82-92. 2007
    ..The suppression of NMDA more than AMPA responses by GHB at intoxicating doses may make it attractive as a recreational drug and may explain why GHB is abused and baclofen is not...
  6. pmc Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid
    Melanie A Felmlee
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Amherst, New York, USA
    J Pharmacol Exp Ther 333:764-71. 2010
    ..These results support the use of a clinical GHB detoxification strategy aimed at decreasing plasma and brain GHB concentrations after GHB overdoses...
  7. ncbi Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain
    Petrine Wellendorph
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
    J Pharmacol Exp Ther 315:346-51. 2005
    ..Neither of the cycloalkenes showed any affinity (IC50 > 1 mM) for GABA(A) or GABA(B) receptors. These compounds show excellent potential as lead structures and novel tools for studying specific GHB receptor-mediated pharmacology...
  8. ncbi gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors
    Paul Schweitzer
    The Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 311:172-9. 2004
    ....
  9. ncbi Presynaptic modulation of spontaneous inhibitory postsynaptic currents by gamma-hydroxybutyrate in the substantia nigra pars compacta
    Alfredo Brancucci
    Dipartimento di Fisiologia e Biochimica G Moruzzi, Universita di Pisa, Pisa, Italy
    Neuropsychopharmacology 29:537-43. 2004
    ..The present results indicate that GHB inhibits spontaneous inhibitory synaptic transmission recorded from dopaminergic neurons in the SNc likely by reducing voltage-dependent calcium influx involved in presynaptic GABA release...
  10. pmc Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory
    Julie Vienne
    Center for Integrative Genomics CIG, University of Lausanne, Lausanne, Switzerland
    Sleep 35:1071-83. 2012
    b>Sodium oxybate (SO) is a GABAβ agonist used to treat the sleep disorder narcolepsy. SO was shown to increase slow wave sleep (SWS) and EEG delta power (0.75-4...
  11. pmc Tolerance and efficacy of sodium oxybate in childhood narcolepsy with cataplexy: a retrospective study
    Michel Lecendreux
    Pediatric Sleep Center, National Reference Network for Orphan Diseases Narcolepsy and Idiopathic Hypersomnia, CHU Robert Debrée, Paris VII University, Paris, France
    Sleep 35:709-11. 2012
    ..ranging from 6 to 16 years old, suffering from narcolepsy with cataplexy, who had been treated with off-label sodium oxybate and had been followed in a clinical setting...
  12. ncbi Sodium oxybate for the treatment of fibromyalgia
    Roland Staud
    University of Florida Medicine, 1600 SW Archer Rd, Gainesville, FL 32610 0221, USA
    Expert Opin Pharmacother 12:1789-98. 2011
    ..Its sodium salt (sodium oxybate: SXB) was approved by the Food and Drug Administration (FDA) for the treatment of narcolepsy...
  13. pmc Effects of GABA agonists on body temperature regulation in GABA(B(1))-/- mice
    Christophe Queva
    Transgenic Research Laboratory, AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Br J Pharmacol 140:315-22. 2003
    ..Using this model, GHB was shown to be a selective GABAB receptor agonist. In addition, GABAB(1)-/- mice are hypersensitive to GABAA receptor stimulation, indicating that GABAB tone normally balances GABAA-mediated effects...
  14. pmc Sodium oxybate-induced sleep driving and sleep-related eating disorder
    Douglas McKay Wallace
    Department of Neurology, Sleep Medicine Division, University of Miami Miller School of Medicine, Miami, FL, USA
    J Clin Sleep Med 7:310-1. 2011
    ..b>Sodium oxybate (SO), the sodium salt of γ-hydroxybutyrate, an inhibitory neurotransmitter, has been associated with dose-..
  15. ncbi Sodium oxybate reduces pain, fatigue, and sleep disturbance and improves functionality in fibromyalgia: results from a 14-week, randomized, double-blind, placebo-controlled study
    I Jon Russell
    Department of Medicine, University of Texas Health Science Center at San Antonio, TX, USA
    Pain 152:1007-17. 2011
    This 14-week, phase 3, double-blind, randomized, controlled trial evaluated sodium oxybate (SXB) 4.5 and 6g per night versus placebo in patients with fibromyalgia (FM). SXB is the sodium salt of γ-hydroxybutyrate (GHB)...
  16. ncbi GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice
    Laura H Jacobson
    Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    J Pharmacol Exp Ther 319:1317-26. 2006
    ..Therefore, GABA(B(1a)) and GABA(B(1b)) isoforms are functionally relevant molecular variants of the GABA(B(1)) receptor subunit, which are differentially involved in specific neurophysiological processes and behaviors...
  17. ncbi Gamma hydroxy butyric acid and sodium oxybate used to treat posttraumatic stress disorder
    Thomas L Schwartz
    Department of Psychiatry, State University of New York, Upstate Medical University, Syracuse, New York, USA
    CNS Spectr 12:884-6. 2007
  18. ncbi A single-blind, open-label trial of sodium oxybate for myoclonus and essential tremor
    S J Frucht
    Columbia University Medical Center, New York, USA
    Neurology 65:1967-9. 2005
    The authors performed an open-label, rater-blinded, add-on study of sodium oxybate in 20 patients with ethanol-responsive myoclonus or essential tremor...
  19. ncbi Effects of sodium oxybate on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome: a double-blind, randomized, placebo-controlled study
    Harvey Moldofsky
    Centre for Sleep and Chronobiology and Toronto Psychiatric Research Foundation, Toronto, Ontario, Canada
    J Rheumatol 37:2156-66. 2010
    To determine the effects of sodium oxybate (SXB) on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome (FM).
  20. ncbi Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice
    Klemens Kaupmann
    Novartis Institutes for BioMedical Research, WKL 125 7 42, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Eur J Neurosci 18:2722-30. 2003
    ..It, therefore, appears that all studied GHB effects are GABAB receptor dependent. The molecular nature and the signalling properties of the specific [3H]GHB-binding sites remain elusive...
  21. ncbi Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator gamma-hydroxybutyrate (GHB)
    Christian Andriamampandry
    Institut de Chimie Biologique and INSERM U 575, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France
    FASEB J 17:1691-3. 2003
    ..CGP-55845, a GABA(B) receptor antagonist, did not inhibit the GHB-induced response nor did the GHB receptor antagonist NCS-382, suggesting that the GHB receptor system includes several subtypes...
  22. ncbi Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2
    Robert C Lyon
    Strathclyde Institute of Pharmacy and Biomedical Sciences, Univesity of Strathclyde, Glasgow G1 1XW, United Kingdom
    J Biol Chem 282:25986-92. 2007
    ..Together these findings delineate pathways for GHB metabolism in the brain and will enable a better understanding of the relationship between GHB biosynthesis and catabolism in disease states and in drug overdose...
  23. ncbi Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease
    M J Picklo
    Department of Pathology, Vanderbilt University Medical Center, C3321 A Medical Center North, Nashville, TN 37232, USA
    Brain Res 916:229-38. 2001
    ..Our data suggest that reactive gliosis, as a response to injury, may affect GHB neuromodulatory pathways in neurodegenerative disease and elevate aldehyde detoxification pathways...
  24. ncbi gamma-Hydroxybutyrate/sodium oxybate: neurobiology, and impact on sleep and wakefulness
    Daniel Pardi
    Jazz Pharmaceuticals Inc, Palo Alto, CA, USA
    CNS Drugs 20:993-1018. 2006
    ..Endogenously, GHB is synthesised locally within the CNS, mostly from its parent compound GABA. Sodium oxybate is the sodium salt of GHB and is used for the exogenous oral administration of GHB...
  25. ncbi Intrathalamic injections of gamma-hydroxybutyric acid increase genetic absence seizures in rats
    Z Liu
    , Centre de Neurochimie du CNRS, Strasbourg, France
    Neurosci Lett 125:19-21. 1991
    ..These data suggest that GHB receptors in the mediolateral thalamus may be involved in the control of spontaneous SWD in this rat model of petit mal epilepsy...
  26. ncbi Sodium oxybate relieves pain and improves function in fibromyalgia syndrome: a randomized, double-blind, placebo-controlled, multicenter clinical trial
    I Jon Russell
    The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Arthritis Rheum 60:299-309. 2009
    To evaluate the safety and efficacy of sodium oxybate for management of the symptoms of fibromyalgia syndrome (FMS).
  27. ncbi The effects of gamma-hydroxybutyrate on the sleep of narcolepsy patients: a double-blind study
    L Scrima
    Sleep Disorders and Research Center, University of Arkansas for Medical Sciences, Little Rock
    Sleep 13:479-90. 1990
    ....
  28. ncbi Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain
    Christian Andriamampandry
    Institut de Chimie Biologique and INSERM U 575, Faculty of Medicine, Strasbourg, France
    FASEB J 21:885-95. 2007
    ..9 microM for NCS-382. The present data led to the conclusion that both C12K32 and GHBh1 are two closely related isoforms of a human GHB receptor, GHBh1, that is described in the databank as the GPCR 172A...
  29. ncbi Sodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience
    R Poryazova
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Eur Neurol 65:175-82. 2011
    b>Sodium oxybate (SO; Xyrem®) has been approved in most countries for treatment of narcolepsy and cataplexy...
  30. pmc Neuropsychiatric morbidity in adolescent and adult succinic semialdehyde dehydrogenase deficiency patients
    Ina Knerr
    Department of Neurology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC, USA
    CNS Spectr 13:598-605. 2008
    ..While neurological manifestations, such as developmental delay, are typical during infancy, limited data are available on adolescent and adult symptomatology...
  31. ncbi A pilot study on the effects of sodium oxybate on sleep architecture and daytime alertness in narcolepsy
    Mortimer Mamelak
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Sleep 27:1327-34. 2004
    To measure the effect of nocturnal sodium oxybate administration on sleep architecture in patients with narcolepsy.
  32. ncbi Gamma-hydroxybutyrate reduces both withdrawal syndrome and hypercortisolism in severe abstinent alcoholics: an open study vs. diazepam
    Felice Nava
    Italian Society of Addiction Medicine FederSerD, Milan, Italy
    Am J Drug Alcohol Abuse 33:379-92. 2007
    ..Taken together, our data suggest that GHB may act as potent anti-withdrawal agent in severe abstinent alcoholics...
  33. pmc The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy
    Jed Black
    Stanford Sleep Medicine Center, 450 Broadway Street, pavilion B, 2nd Floor, Redwood City, CA 94063 5730, USA
    J Clin Sleep Med 6:596-602. 2010
    To further explore the effects of sodium oxybate (SXB) administration on nocturnal sleep in narcolepsy patients during a double-blind, placebo-controlled, parallel group study conducted with 228 adult patients with narcolepsy/cataplexy in ..
  34. ncbi The effects of sodium oxybate on clinical symptoms and sleep patterns in patients with fibromyalgia
    Martin B Scharf
    Tri State Sleep Disorders Center, Cincinnati, Ohio 45246, USA
    J Rheumatol 30:1070-4. 2003
    ..b>Sodium oxybate has been shown to increase both slow-wave sleep and growth hormone levels...
  35. ncbi GABA shunt deficiencies and accumulation of reactive oxygen intermediates: insight from Arabidopsis mutants
    Aaron Fait
    Department of Plant Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel
    FEBS Lett 579:415-20. 2005
    ..These results provide novel evidence for the relationship between the GABA shunt and ROI, which may, in part, explain the phenotype of SSADH-deficient plants and animals...
  36. ncbi Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice)
    S W Sauer
    Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children s Hospital, Heidelberg, Germany
    Neurochem Int 50:653-9. 2007
    ..Although our results suggest hippocampal and cortical dysfunction in Aldh5a1(-/-) brain, we found no evidence that accumulating key metabolites of SSADH deficiency directly induce impairment of energy metabolism...
  37. pmc Treatment of narcolepsy and other hypersomnias of central origin
    Merrill S Wise
    Methodist Healthcare Sleep Disorders Center Memphis, Tennessee, USA
    Sleep 30:1712-27. 2007
    ..The purpose of this paper is to summarize current knowledge about treatment of narcolepsy and other hypersomnias of central origin...
  38. ncbi Gamma hydroxybutyric acid (GHB) intoxication
    Phillip E Mason
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
    Acad Emerg Med 9:730-9. 2002
    ..Emergency physicians should be familiar with the presentation and management of GHB-related emergencies...
  39. ncbi Sodium oxybate: a review of its use in the management of narcolepsy
    Dean M Robinson
    Wolters Kluwer Health Adis, Auckland, New Zealand
    CNS Drugs 21:337-54. 2007
    b>Sodium oxybate (Xyrem) is the sodium salt of the CNS depressant gamma-hydroxybutyric acid (GHB) and is therefore subject to prescription restrictions...
  40. ncbi Sodium oxybate for excessive daytime sleepiness in narcolepsy-cataplexy
    Isabelle Arnulf
    Sleep 27:1242-3. 2004
  41. ncbi Weight loss in narcolepsy patients treated with sodium oxybate
    Aatif M Husain
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC, United States
    Sleep Med 10:661-3. 2009
    Narcolepsy is often associated with increased body weight. Sodium oxybate has efficacy in many narcolepsy symptoms. The purpose of this study was to evaluate the effects of sodium oxybate on weight in patients with narcolepsy.
  42. ncbi Sodium oxybate for excessive daytime sleepiness in Parkinson disease: an open-label polysomnographic study
    William G Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Ste 1801, Houston, TX 77030, USA
    Arch Neurol 65:1337-40. 2008
    ..Many patients with Parkinson disease (PD) have excessive daytime sleepiness and numerous nocturnal sleep abnormalities...
  43. pmc Enhancing slow wave sleep with sodium oxybate reduces the behavioral and physiological impact of sleep loss
    James K Walsh
    Sleep Medicine and Research Center, St Luke s Hospital, Chesterfield, MO 63017, USA
    Sleep 33:1217-25. 2010
    To investigate whether enhancement of slow wave sleep (SWS) with sodium oxybate reduces the impact of sleep deprivation.
  44. ncbi Sodium oxybate in maintaining alcohol abstinence in alcoholic patients with and without psychiatric comorbidity
    Fabio Caputo
    G Fontana Centre for the Study and Multidisciplinary Treatment of Alcohol Addiction, Department of Internal Medicine, Cardioangiology and Hepatology, University of Bologna, Italy
    Eur Neuropsychopharmacol 21:450-6. 2011
    b>Sodium oxybate (SMO) is a GABA-ergic drug currently used for the treatment of alcohol-dependence in some European countries...
  45. ncbi Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate
    Yu Shu Huang
    Sleep Disorders Clinic, Department of Child Psychiatry, Chang Gung University Memorial Hospital, Taipei, Taiwan
    Pediatr Neurol 41:9-16. 2009
    This study was performed to evaluate the actions of baclofen and sodium oxybate, two medications with gamma-aminobutyric acid type B (GABA(B)) receptor agonist properties, on symptoms of narcolepsy in drug-naïve teenagers...
  46. ncbi Three deaths associated with use of Xyrem
    Deborah L Zvosec
    Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Sleep Med 10:490-3. 2009
    ..We report three deaths associated with use of Xyrem (sodium oxybate), a pharmaceutical preparation of GHB initially approved for treatment of narcolepsy with cataplexy...
  47. ncbi Sodium oxybate in the treatment of binge eating disorder: an open-label, prospective study
    Susan L McElroy
    Research Institute, Lindner Center of HOPE, Mason, Ohio, USA
    Int J Eat Disord 44:262-8. 2011
    To assess preliminarily the effectiveness of sodium oxybate in binge eating disorder.
  48. ncbi Effect of sodium oxybate on growth hormone secretion in narcolepsy patients and healthy controls
    Claire E H M Donjacour
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 300:E1069-75. 2011
    ..Symptoms can be treated effectively with sodium oxybate (SXB; γ-hydroxybutyrate) in many patients...
  49. ncbi A safety trial of sodium oxybate in patients with obstructive sleep apnea: Acute effects on sleep-disordered breathing
    Charles F P George
    University of Western Ontario, London Health Sciences Centre, 375 South Street, London, Ont, Canada N6A 4G5
    Sleep Med 11:38-42. 2010
    b>Sodium oxybate (SXB) is an approved drug for the treatment of excessive daytime sleepiness (EDS) and cataplexy in narcolepsy. Obstructive sleep apnea syndrome (OSAS) is a condition that frequently co-occurs with narcolepsy...
  50. ncbi A multi-drug intoxication fatality involving Xyrem (GHB)
    Brianne E Akins
    Washington State Patrol, Forensic Laboratory Services Bureau, 2203 Airport Way S, Suite 360, Seattle, WA 98134, USA
    J Forensic Sci 54:495-6. 2009
    ..The manner of death was determined to be accidental...
  51. ncbi Significant behavioral disturbances in succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hydroxybutyric aciduria)
    K Michael Gibson
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97201, USA
    Biol Psychiatry 54:763-8. 2003
    ....
  52. pmc A 2-week, polysomnographic, safety study of sodium oxybate in obstructive sleep apnea syndrome
    Charles F P George
    University of Western Ontario, London Health Sciences Centre, 375 South Street, London, ON, N6A 4G5, Canada
    Sleep Breath 15:13-20. 2011
    b>Sodium oxybate (SXB) is approved for cataplexy and excessive daytime sleepiness in narcolepsy. Obstructive sleep apnea syndrome (OSAS) affects ∼9-50% of narcoleptics...
  53. ncbi gamma-Hydroxybutyrate (GHB) induces GABA(B) receptor independent intracellular Ca2+ transients in astrocytes, but has no effect on GHB or GABA(B) receptors of medium spiny neurons in the nucleus accumbens
    T Molnar
    Department of Neurochemistry, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri út 59 67 1025, Budapest, Hungary
    Neuroscience 162:268-81. 2009
    ....
  54. ncbi Metabolism of gamma-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenase
    Eduard A Struys
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Metabolism 55:353-8. 2006
    ..Our results indicate that d-2-HG is a prominent GHB metabolite and provide further evidence for the existence of d-2-hydroxyglutarate transhydrogenase in different mammalian species...
  55. ncbi Sodium oxybate improves excessive daytime sleepiness in narcolepsy
    Jed Black
    Stanford Sleep Disorders Clinic, CA 94305, USA
    Sleep 29:939-46. 2006
    To assess the effectiveness of sodium oxybate therapy, modafinil therapy and the combination of the two for excessive daytime sleepiness in narcolepsy patients previously taking modafinil.
  56. ncbi Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate
    A Robert Spitzer
    Neurology Department, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pain Pract 10:54-9. 2010
    ..When considered appropriate based on the clinical picture and test results, treatment with sodium oxybate was offered to these patients...
  57. ncbi Comment on "The abrupt cessation of therapeutically administered sodium oxybate (GHB) may cause withdrawal symptoms"
    Deborah L Zvosec
    J Toxicol Clin Toxicol 42:121-3; author reply 125-7. 2004
  58. ncbi Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 189:71-82. 2006
    ..Abuse of gamma-hydroxybutyrate (GHB) and its precursors is a public health concern. Gamma-butyrolactone (GBL) is found in commercially available products and, when ingested, is metabolized to GHB...
  59. ncbi The epidemiology of GHB and ketamine use in an Australian household survey
    Louisa Degenhardt
    National Drug and Alcohol Research Centre, University of NSW, Sydney, NSW 2052, Australia
    Int J Drug Policy 19:311-6. 2008
    ..This paper provides the first such Australian data on the patterns and correlates of GHB and ketamine use...
  60. ncbi Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348
    Wouter Koek
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 192:407-14. 2007
    ..Gamma-hydroxybutyrate (GHB) is used to treat narcolepsy but is also abused. GHB has many actions in common with the GABA(B) receptor agonist baclofen...
  61. ncbi The role of the new "date rape drugs" in attributions about date rape
    April L Girard
    University of Windsor, Ontario, Canada
    J Interpers Violence 23:3-20. 2008
    ..These findings extend the limited research on date rape drugs and previous work on the influence of alcohol on date rape attributions...
  62. ncbi GHB use among gay and bisexual men
    Perry N Halkitis
    Center for Health, Identity, Behavior and Prevention Studies, New York University, United States
    Addict Behav 31:2135-9. 2006
    ..Use of GHB is common among a certain subset of gay men despite warnings within the community about the potentially fatal effects of the substance, suggesting that more effort be given to educate drug using gay men about GHB...
  63. ncbi Club drug use among youths in treatment for substance abuse
    Christian Hopfer
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Addict 15:94-9. 2006
    ..01). Youths reported using club drugs frequently outside of rave settings. Club drug use is common among youths in treatment for substance abuse and has spread beyond the rave culture...
  64. ncbi Effects of gamma-hydroxybutyrate (GHB) and its metabolic precursors on delayed-matching-to-position performance in rats
    Daniel Kueh
    Department of Psychology, Western Michigan University, Kalamazoo, MI 49008 5439, USA
    Pharmacol Biochem Behav 89:179-87. 2008
    ..Moreover, the acute effects of GHB under the DMTP procedure resemble those of its metabolic precursors, GBL and 1,4-BD, and of the prototypical CNS depressant drug, ethanol...
  65. ncbi Club drugs: methylenedioxymethamphetamine, flunitrazepam, ketamine hydrochloride, and gamma-hydroxybutyrate
    Kelly M Smith
    Drug Information Center, University of Kentucky Chandler Medical Center UKCMC, Lexington, USA
    Am J Health Syst Pharm 59:1067-76. 2002
    ..The increasing abuse of MDMA, flunitrazepam, ketamine hydrochloride, and GHB, particularly by young people in social settings such as clubs, should put health care professionals on guard to recognize and manage serious reactions...
  66. pmc An interactive lesson in acid/base and pro-drug chemistry using sodium gamma-hydroxybutyrate and commercial test coasters
    Nathaniel A Page
    School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, NY 14260, USA
    Am J Pharm Educ 71:54. 2007
    ....
  67. ncbi Medical and legal confusion surrounding gamma-hydroxybutyrate (GHB) and its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4BD)
    D M Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, Avonley Road, London, UK
    QJM 101:23-9. 2008
    ..However, its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4BD) remain legally available despite having similar clinical effects...
  68. ncbi Unusually high concentrations in a fatal GHB case
    Pascal Kintz
    X pertise Consulting, Laboratoire ChemTox, 3 rue Gruninger, F 67400 Illkirch, France
    J Anal Toxicol 29:582-5. 2005
    ..4 to 25.0 ng/mg (in comparison with physiological concentrations < 2 ng/mg). Methylenedioxymethamphetamine was present in femoral blood at 144 ng/mL. These results are consistent with an acute fatal overdose of GHB...
  69. ncbi Distribution of GHB in tissues and fluids following a fatal overdose
    Susan Mazarr-Proo
    New Mexico Department of Health, Scientific Laboratory Division, Toxicology Bureau, Albuquerque, 87196 4700, USA
    J Anal Toxicol 29:398-400. 2005
    ..The cause of death was attributed to GHB intoxication, and the manner of death was accidental...
  70. ncbi Detection of gamma-hydroxybutyrate in striatal microdialysates following peripheral 1,4-butanediol administration in rats
    Roopa Kapadia
    Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA 02115, USA
    Life Sci 80:1046-50. 2007
    ..Sleep times in animals were similarly correlated with GHB concentrations in the microdialysates...
  71. pmc Experiences of gamma hydroxybutyrate (GHB) ingestion: a focus group study
    Judith C Barker
    Department of Anthropology, History and Social Medicine, University of California, San Francisco 94143 0850, USA
    J Psychoactive Drugs 39:115-29. 2007
    ..It concludes with a discussion of the implications drawn from this information for clinicians treating patients who use GHB...
  72. ncbi Determination of gamma-hydroxybutyrate (GHB) and its precursors in blood and urine samples: a salting-out approach
    Aino Kankaanpää
    Drug Research Unit, Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland
    Forensic Sci Int 170:133-8. 2007
    ..As revealed by the validation data this procedure is suitable for quantitative determination of GHB and its precursors in blood and/or urine samples...
  73. ncbi Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice
    Charles D Cook
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 160:99-106. 2002
    ..In addition to its uncertain physiological role, the recent interest in GHB has been engendered by its illicit use and abuse...
  74. ncbi A randomized trial evaluating the effectiveness of sodium oxybate therapy on quality of life in narcolepsy
    Terri E Weaver
    Biobehavioral and Health Sciences Division, University of Pennsylvania School of Nursing, 420 Guardian Drive, Philadelphia, PA 19104 6096, USA
    Sleep 29:1189-94. 2006
    To evaluate the efficacy of sodium oxybate versus placebo to improve quality of life in patients with narcolepsy.
  75. ncbi The motor-impairing effects of GABA(A) and GABA(B) agonists in gamma-hydroxybutyrate (GHB)-treated rats: cross-tolerance to baclofen but not flunitrazepam
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
    Eur J Pharmacol 552:83-9. 2006
    ..These findings are consistent with the in vivo behavioral profile of GHB, which reveals a greater role for GABA(B) receptors than for GABA(A) receptors in its behavioral effects...
  76. ncbi Physostigmine for gamma-hydroxybutyrate coma: inefficacy, adverse events, and review
    Deborah L Zvosec
    Department of Emergency Medicine, Hennepin County Medical Center Minneapolis, Medical Research Foundation, Minneapolis, Minnesota 55415, USA
    Clin Toxicol (Phila) 45:261-5. 2007
    ....
  77. ncbi [New Drugs: Ectasy and Gamma-Hydroxy-Butyrate (GHB)]
    Nelson Feldman
    Division d abus de substances, D and eacutepartament de Psychiatrie, HUG, Geneve, Suisse
    Vertex 13:5-8. 2002
    ..In this article, their authors describe the secondary and toxic effects of those drugs. These data should alert about the risk of considering this new way of substance abuse as a banal fact...
  78. ncbi GHB use among Australians: characteristics, use patterns and associated harm
    Louisa Degenhardt
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    Drug Alcohol Depend 67:89-94. 2002
    ..The high rate of problems reported by a group with limited use of this drug suggests that in a context of polydrug use, GHB use is associated with significant risks to users...
  79. ncbi Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. administration in rats
    Lawrence P Carter
    The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive MC7764, San Antonio, TX 78229, USA
    Eur J Neurosci 24:2595-600. 2006
    ....
  80. ncbi The Discriminative stimulus effects of gamma-hydroxybutyrate and related compounds in rats discriminating baclofen or diazepam: The role of GABA(B) and GABA(A) receptors
    L P Carter
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Pharmacol Exp Ther 309:540-7. 2004
    ..The inability of CGP 35348 to completely attenuate the effects of baclofen and GHB suggests that multiple receptors could be involved in the discriminative stimulus effects of GHB...
  81. pmc High-risk behaviors and hospitalizations among gamma hydroxybutyrate (GHB) users
    Susan Y Kim
    California Poison Control System, Department of Clinical Pharmacy, University of California, San Francisco, CA 94143 1369, USA
    Am J Drug Alcohol Abuse 33:429-38. 2007
    ..Little is known about behaviors linked to gamma hydroxybutyrate (GHB) morbidity...
  82. ncbi A validated SPME-GC-MS method for simultaneous quantification of club drugs in human urine
    Stacy D Brown
    The Citadel, Chemistry Department, 171 Moultrie Street, Charleston, SC 29409 6220, United States
    Forensic Sci Int 171:142-50. 2007
    ..This method has the advantage of an easy sample preparation with acceptable accuracy and precision for the simultaneous quantification of these four drugs of abuse and shows no interference from the urine matrix...
  83. ncbi Use of alcohol during the treatment of alcohol dependence with gamma-hydroxybutyric acid: risk of severe events are avoided by the dose fractioning of the drug
    Fabio Caputo
    J Clin Psychopharmacol 27:418. 2007
  84. ncbi Recent trends in the use of "club drugs": an Australian review
    Louisa Degenhardt
    National Drug and Alcohol Research Centre, University of NSW, Sydney, NSW, Australia
    Subst Use Misuse 40:1241-56. 2005
    ..This could be most easily achieved by the inclusion of MDMA, ketamine, and GHB in household surveys that are currently collected routinely in a number of countries...
  85. ncbi A brief overview of the clinical pharmacology of "club drugs"
    Gena Covell Britt
    Division of Addiction Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23219, USA
    Subst Use Misuse 40:1189-201. 2005
    ..The neurobiology, clinical pharmacology, and treatment issues for each are discussed...
  86. ncbi Club drugs: reasons for and consequences of use
    Kathleen A Parks
    Research Institute on Addictions, 1021 Main Street, Buffalo, New York 14203, USA
    J Psychoactive Drugs 36:295-302. 2004
    ..Further exploration of the reasons and positive consequences that are associated with use of each of the club drugs may provide important information on the growing trend in use of these drugs...
  87. ncbi Rave drugs: pharmacological considerations
    Carl S Hornfeldt
    AANA J 72:334-5; author reply 335. 2004
  88. ncbi Addicted to driving under the influence--a GHB/GBL case report
    Fiona J Couper
    Office of the Chief Medical Examiner, 1910 Massachusetts Avenue SE, Washington, D C 20003, USA
    J Anal Toxicol 28:512-5. 2004
    ..During the same period as his DUI arrests, the subject had been admitted at least six times to different hospitals for GHB/GBL intoxications...
  89. ncbi Protection by the GABAB receptor antagonist, SCH 50911, of gamma-hydroxybutyric acid-induced mortality in mice
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Eur J Pharmacol 503:77-80. 2004
    ....
  90. ncbi Extractionless GC/MS analysis of gamma-hydroxybutyrate and gamma-butyrolactone with trifluoroacetic anhydride and heptafluoro-1-butanol from aqueous samples
    Alberto J Sabucedo
    Florida International University, University Park, Department of Chemistry and Biochemistry, Advanced Mass Spectrometry Facility, Miami, Florida 33199, USA
    J Sep Sci 27:703-9. 2004
    ..The concentration of GBL can also be indirectly determined by the method developed. Therefore, this extractionless technique is rapid, sensitive, and selective for the confirmation of the presence of GHB and GBL in commercial beverages...
  91. ncbi A study of urinary endogenous gamma-hydroxybutyrate (GHB) levels
    Dustin Tate Yeatman
    Toxicology Section, Florida Department of Law Enforcement, Orlando, Florida, USA
    J Anal Toxicol 27:40-2. 2003
    ..3 mg/mL (mean = 1.65 microg/mL, range 0.9 microg/mL to 3.5 microg/mL, standard deviation 0.68 microg/mL). The results of this study confirm the previously suggested cutoff of 10 microg/mL for routine forensic analyses...
  92. ncbi Gamma-butyrolactone and 1,4-butanediol: abused analogues of gamma-hydroxybutyrate
    Robert B Palmer
    Toxicology Associates, Prof LLC, Denver, Colorado, USA
    Toxicol Rev 23:21-31. 2004
    ..This review examines the history of GHB analogue abuse as well as the clinical presentation and management of acute intoxication and withdrawal associated with abuse of these compounds...
  93. ncbi GHB and date rape
    M Z Abramowitz
    Br J Psychiatry 185:176-7. 2004
  94. pmc Systematic assessment of gamma hydroxybutyrate (GHB) effects during and after acute intoxication
    Susan Y Kim
    California Poison Control System, Department of Clinical Pharmacy, San Francisco, University of California, San Francisco, California 94143 1369, USA
    Am J Addict 17:312-8. 2008
    ..001). This modified substance-specific symptom battery, which is easily administered, demonstrated excellent performance characteristics. It can be used to study GHB and, potentially, related drugs of abuse...
  95. ncbi Common drugs of abuse--Part II
    Mary Linda Stotter Cuddy
    J Pract Nurs 54:5-8, 25-31; quiz 17-9. 2004
    ..Drug abuse affects a significant number of individuals of all ages. Health care practitioners must be knowledgeable about both the physiological effects of such drugs and the impact of drug-seeking behavior on their patients...
  96. ncbi Narcolepsy
    Neil T Feldman
    St Petersburg Sleep Disorders Center, St Petersburg, FL 33707, USA
    South Med J 96:277-82. 2003
    ..Primary-care physicians who develop the proper diagnostic skills can play a pivotal role in the accurate diagnosis and long-term management of patients suffering from narcolepsy...
  97. ncbi Medical problems related to recreational drug use at nocturnal dance parties
    Diederik K Van Sassenbroeck
    Heymans Institute for Pharmacology, University of Ghent, Faculty of Medicine and Health Sciences, Ghent, Belgium
    Eur J Emerg Med 10:302-8. 2003
    ....
  98. ncbi Characterization of the pharmacokinetic and pharmacodynamic interaction between gamma-hydroxybutyrate and ethanol in the rat
    Diederik K Van Sassenbroeck
    Heymans Institute of Pharmacology, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, B 9000 Ghent, Belgium
    Toxicol Sci 73:270-8. 2003
    ..Pharmacodynamic interactions between GHB and ethanol in the rat occur, and the nature varies with the reflex studied and the concentration of ethanol used...
  99. ncbi Liquid ecstasy: a new kid on the dance floor
    J Rodgers
    Br J Psychiatry 184:104-6. 2004
  100. ncbi Acute toxic effects of club drugs
    Robert S Gable
    School of Behavioral and Organizational Sciences, Claremont Graduate University, Claremont, California, USA
    J Psychoactive Drugs 36:303-13. 2004
    ..Hazardous drug-use sequelae such as accidents, aggressive behavior, and addiction were not factored into the safety ratio estimates...

Research Grants62

  1. Orexin Receptor Agonists for the Treatment of Excessive Daytime Sleepiness and Ca
    PAUL STUART HUMPHRIES; Fiscal Year: 2013
    ..g. modafinil). Currently, only one medication, sodium oxybate, is approved by the FDA for the treatment of cataplexy in narcoleptic patients...
  2. Voice tremor in spasmodic dysphonia: central mechanisms and treatment response
    Kristina Simonyan; Fiscal Year: 2013
    ..as the basis for characterization of central mechanisms underlying symptom improvement following the use of sodium oxybate, a novel pharmacological agent for treatment of ethanol-responsive dystonia...
  3. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  4. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  5. Self-administration of GHB, GBL and 1,4-BD in baboons
    AMY GOODWIN; Fiscal Year: 2005
    ..The results of the proposed study will characterize the abuse liability of GHB, GBL, and 1,4-BD by use of a well-established method of abuse liability testing in non-human primates. ..
  6. Motivation and Skills for THC/ETOH+ Teens in Jail
    LYN STEIN; Fiscal Year: 2008
    ..The development of effective interventions for substance using juvenile offenders has the potential to reduce substance abuse and crime in this population. ..
  7. MOTIVATIONAL INTERVIEWS FOR INCARCERATED TEENS
    Lynda Stein; Fiscal Year: 2003
    ..The development of effective interventions for substance using juvenile offenders has the potential to reduce substance abuse and crime in this population. ..
  8. GHB: Discrimination and effects on learning
    Lisa Baker; Fiscal Year: 2003
    ..Behavior under these assays is sensitive to other abused drugs. Therefore, these assays may be of value in characterizing the effects of GHB. ..
  9. Role of Histamine in Narcolepsy/EDS Disorders
    Seiji Nishino; Fiscal Year: 2008
    ..As almost nothing is known on the pathophysiology of non- hypocretin deficient hypersomnias, we believe this work to be ideally suited for a small grant application. [unreadable] [unreadable] [unreadable]..
  10. Role of hypocretin/histamine in Narcolepsy/EDS disorders
    Seiji Nishino; Fiscal Year: 2009
    ..We believe that results from these studies will bring new insights regarding the roles of the hypocretin/histamine interaction in narcolepsy and other EDS disorders and better treatment modalities in humans. ..
  11. CLUB DRUG USE AND MEN'S HEALTH--A COMMUNITY STUDY
    Perry Halkitis; Fiscal Year: 2003
    ....
  12. Toxicokinetics and Toxicodynamics of GHB and Precursors
    Ho Leung Fung; Fiscal Year: 2004
    ..A pharmacogenetic mapping of the pharmacological effects of GHB will be obtained. The effects of tolerance development, withdrawal, gender, receptor blockade on these effects will be examined. ..
  13. Organic Nitrate Metabolism, Tolerance and Action
    Ho Leung Fung; Fiscal Year: 2010
    ..believe that our studies can provide new and meaningful data that will contribute to the establishment of a unifying mechanism for organic nitrate action and deleterious effects, and lead to their better therapeutic use ..
  14. PROTEASE INHIBITOR ADHERENCE AMONG DRUG USERS
    Perry Halkitis; Fiscal Year: 2002
    ..Generalized linear, Markov regression, and structural equation modeling will be used to achieve the study's goals. ..
  15. Toxicokinetics and Toxicodynamics of Nitrite Inhalants
    Ho Leung Fung; Fiscal Year: 2005
    ..We believe that our proposal represents novel approaches toward the understanding of nitrite inhalant toxicity in vivo. ..
  16. PHARMACOLOGICAL STUDIES OF HUMAN AND CANINE NARCOLEPSY
    Seiji Nishino; Fiscal Year: 2002
    ....
  17. Serotonin Receptor Subtypes: Regulation and Interaction
    JULIE HENSLER; Fiscal Year: 2008
    ..Studies of the regulation of 5-HT1A receptor function may have important implications for our understanding the role of this receptor in the therapeutic action of drugs used to treat mental illness [unreadable] [unreadable]..
  18. Development and Evaluation of a Group HIV Intervention for Gender Stigmatized Per
    Jeffrey Parsons; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  19. 5HT transporter & 1A receptor function in BDNF mice
    JULIE HENSLER; Fiscal Year: 2007
    ..Region-specific and age-dependent changes in BDNF protein levels will be determined in selected brain regions of wild-type and BDNF () mice (Aim #3). [unreadable] [unreadable] [unreadable]..
  20. MECHANISM OF PAIN IN PATIENTS WITH FIBROMYALGIA SYNDROME
    Roland Staud; Fiscal Year: 2008
    ..In addition, our findings may contribute to the understanding of pain mechanisms related to other chronic pain disorders. ..
  21. GHB: Effects, Withdrawal and Treatment
    Karen Miotto; Fiscal Year: 2006
    ..There has been little systematic study of the signs and symptoms of withdrawal, and controlled studies on the effectiveness of treatment of these symptoms are lacking. ..
  22. College Women: The Alcohol and Victimization Link
    KATHLEEN PARKS MARSH; Fiscal Year: 2008
    ..This research is innovative in the use of long- and short-term measures, within a longitudinal design, to assess alcohol-related victimization of college women. ..
  23. Contingency Management: Duration Effects
    John Roll; Fiscal Year: 2007
    ..This is timely, given the burgeoning rates of methamphetamine abuse being reported. ..
  24. Role of Hypocretin in Metabolic Effects of Sleep Loss
    Emmanuel Mignot; Fiscal Year: 2008
    ..These studies will be critical to extend our understanding of the association between chronic sleep loss, metabolism and body weight regulation. ..
  25. Opioid Antagonist Discrimination: A Model of Withdrawal
    Alison Oliveto; Fiscal Year: 2011
    ..This paradigm provides a sensitive, standard, objective, systematic method to identify potential agents for enhancing OW treatment which can be examined further in a detox protocol. ..
  26. Behavioral Economic Analysis of Polydrug Abuse
    GAIL D WINGER; Fiscal Year: 2010
    ....
  27. Disulfiram for Cocaine Abuse in Metadone - Patients
    Alison Oliveto; Fiscal Year: 2010
    ..The prognostic relevance of other factors (e.g., sex, discounting behavior) will also be examined. ..
  28. Human Behavorial Pharmacology of GHB
    John Roll; Fiscal Year: 2002
    ....
  29. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  30. Control of Muscle Tone in nonREM Sleep
    Jerome Siegel; Fiscal Year: 2009
    ..Our work will also suggest improved pharmacological treatments for PLMS, sleepwalking and bruxism. ..
  31. Behavioral and Pharmacological Analysis of Drugs of Abuse
    JERROLD WINTER; Fiscal Year: 2008
    ..This likelihood coupled with continued interest in the therapeutic use of agents such as psilocybin makes a detailed pharmacological assessment of these drugs of utmost importance. ..
  32. Risk Reduction Intervention for Highly Vulnerable Emerging Adults Males
    Jeffrey T Parsons; Fiscal Year: 2010
    ..If effective, the intervention will help minimize the negative physical and psychological effects associated with club drug use, and reduce HIV infections among emerging adult males. ..
  33. Behavior Change: Reinforcemnt Schedule Effects
    John Roll; Fiscal Year: 2006
    ..Based on the widespread success of contingency management across many different applications, we believe that the results of the proposed study will have 9enerality beyond the field of substance abuse treatment. ..
  34. SECONDARY PREVENTION AMONG HIV POSITIVE ALCOHOL ABUSERS
    Jeffrey Parsons; Fiscal Year: 2001
    ..Participants will complete assessment batteries at intake, and at 1-week, 3, 6, 9, and 12 month follow-ups in order to assess short-term and long-term effects. ..
  35. BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
    JERROLD WINTER; Fiscal Year: 2005
    ..abstract_text> ..
  36. LIPID PEROXIDATION, TOXICANTS, AND MITOCHONDRIA
    MATTHEW PICKLO; Fiscal Year: 2003
    ..With this knowledge, novel therapeutic interventions or preventative strategies may be designed for these diseases. ..
  37. Cue-Reactivity and Alcohol Self-Dosing
    Elise Weerts; Fiscal Year: 2003
    ..This research will additionally provide important information on the behavioral processes underlying conditioned responses to drug-related cues in animals which may be relevant to cue-reactivity and drug-taking in humans. ..
  38. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  39. Submissive Behavior as a Model of Depression
    Godfrey Tunnicliff; Fiscal Year: 2002
    ..The identification of genetic elements in mice associated with depression-like behavior can be tested for homology in human patients that could ultimately lead to an understanding of genetic defects underlying depression in humans. ..
  40. Human Methamphetamine Use: A Model
    John Roll; Fiscal Year: 2002
    ..Studies using laboratory models of human drug use can inform subsequent clinical trials and help to focus them on those variables which are likely to be important. ..
  41. ADOLESCENT SMOKING CESSATION
    John Roll; Fiscal Year: 2002
    ..Secondarily, the proposed study will provide valuable information on the nicotine withdrawal syndrome in adolescents, a topic about which relatively little is known. ..
  42. SLEEP HOMEOSTASIS AND STIMULANT DRUGS OF ABUSE
    Emmanuel Mignot; Fiscal Year: 2002
    ....
  43. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 2002
    ....
  44. Ethanol, HNE, and the CNS
    MATTHEW PICKLO; Fiscal Year: 2005
    ..These data may lead to the formation of new preventative and therapeutic strategies for ethanol-mediated neurotoxicity. ..
  45. GHB Abuse: Motivations, Medical consequences, & Risks
    Jo Dyer; Fiscal Year: 2006
    ..SIGNIFICANCE: This study, by elucidating predictors of adverse outcomes from GHB use will provide data important for clinical and public health interventions to reduce morbidity associated with this drug of abuse. ..
  46. Measuring and Modifying Ethanol's Reinforcing Effects
    Gail Winger; Fiscal Year: 2006
    ..Data relevant to the behavioral and pharmacological mechanisms underlying polydrug abuse involving ethanol, and underlying pharmacological treatment of alcoholism will also be obtained. ..
  47. Adherence Intervention for HIV + Alcohol Users
    Jeffrey Parsons; Fiscal Year: 2005
    ..Multivariate repeated measures analyses and growth curve modeling, using both continuous and dichotomous outcome variables, will be used to assess the impact of the intervention on both adherence and alcohol use. ..
  48. Sleep Disordered Breathing, APOE and Lipid Metabolism
    Emmanuel Mignot; Fiscal Year: 2005
    ..With lipid metabolism being critical to cardiovascular risk, this application will also trigger further studies focusing on cardiovascular impact with adequate control of SDB. ..
  49. Cannabinoids and Central Neuronal Activity
    Paul Schweitzer; Fiscal Year: 2005
    ..abstract_text> ..
  50. Behavioral Effects of GHB in Healthy Volunteers
    ALISON OLIVETO BEAUDOIN; Fiscal Year: 2003
    ..This study will also potentially establish a standard methodology to characterize systematically the behavioral effects of GHB in humans. ..
  51. Sleep in Cetaceans
    Jerome Siegel; Fiscal Year: 2006
    ..The proposed studies take advantage of a rapidly vanishing opportunity to study cetacean sleep. They will improve our understanding of the physiological and neurochemical substrates of mammalian sleep. ..
  52. Women Bar Drinkers: Exploring Risks for HIV
    KATHLEEN PARKS MARSH; Fiscal Year: 2006
    ..It also has the potential to provide information that can be used to develop effective prevention programs to reduce women's risk for HIV. ..
  53. Alcohol Sensitivity and PET Derived Measures of Opioid Activity
    Elise M Weerts; Fiscal Year: 2010
    ..The results of the proposed research will increase our understanding of to the relationship between individual variability in the opioid system and subjective sensitivity to alcohol. ..
  54. Behavioral Pharmacology and GHB Physical Dependence
    Elise M Weerts; Fiscal Year: 2010
    ..Physical dependence in the context of self-injection of GHB, GBL and 1,4-BD will also be evaluated. These studies will provide critical information on the behavioral pharmacology and dependence-producing effects of GHB. ..
  55. Patterns and Contexts of Club Drug Abuse
    Jeffrey Parsons; Fiscal Year: 2007
    ..Mixed-methods strategies will be used to examine the qualitative and quantitative data together in order to further understand the data and potential implications for intervention development. ..
  56. Studies on the role of GABA in Cocaine Addiction
    Elise Weerts; Fiscal Year: 2005
    ..The results of these studies will increase our understanding of the role of GABA in the behavioral effects of cocaine and may lead to the development of better medications for the treatment of cocaine addiction. ..
  57. Impact of CPAP on Functional Outcomes in Milder OSA
    Terri Weaver; Fiscal Year: 2006
    ..Secondary aims of the study are: 1) to examine whether CPAP also improves daytime sleepiness; 2) to determine whether CPAP can reduce nocturnal blood pressure to lower the risk for stroke and hypertension linked to OSA. ..
  58. Mechanisms of Signal Transduction of GHB Action
    Godfrey Tunnicliff; Fiscal Year: 2002
    ..In turn, this will help to develop therapeutic and preventive strategies resulting in a lessened abuse potential of GHB. ..
  59. STIMULANTS, DEPRESSANTS & HALLUCINOGENS AS REINFORCERS
    Gail Winger; Fiscal Year: 2003
    ..These drugs can be those that the WHO or the FDA is considering for scheduling decisions, drugs made by industrial or academic medicinal chemists, or industrial drugs that are being considered for clinical testing. ..
  60. TRAINING IN FUNCTIONAL IMAGING AND ALCOHOL WITHDRAWAL
    DONALD MYRICK; Fiscal Year: 2004
    ....