diethylhexyl phthalate

Summary

Summary: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.

Top Publications

  1. pmc The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms
    Jerome N Feige
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    Environ Health Perspect 118:234-41. 2010
  2. ncbi Di(2-ethylhexyl)phthalate (DEHP): human metabolism and internal exposure-- an update and latest results
    H M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Androl 29:155-65; discussion 181-5. 2006
  3. ncbi Measurement of eight urinary metabolites of di(2-ethylhexyl) phthalate as biomarkers for human exposure assessment
    M J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Biomarkers 11:1-13. 2006
  4. ncbi Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate
    Bethany R Hannas
    Toxicology Assessment Division, Reproductive Toxicology Branch, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:206-16. 2011
  5. pmc Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes
    Sandrine Ellero-Simatos
    INSERM, UMR 775, Universite Paris Descartes, Sorbonne Paris Cité, 45 Rue des Saints Peres, 75006 Paris, France
    J Proteome Res 10:5493-502. 2011
  6. ncbi A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
    Kembra L Howdeshell
    Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 105:153-65. 2008
  7. pmc Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro
    François Chauvigné
    INSERM Institut National de la Santé et de la Recherche Médicale, U625, GERHM, Universite Rennes I, Campus de Beaulieu, Rennes, Bretagne, France
    Environ Health Perspect 117:515-21. 2009
  8. pmc In vitro acute exposure to DEHP affects oocyte meiotic maturation, energy and oxidative stress parameters in a large animal model
    Barbara Ambruosi
    Department of Animal Production, University of Bari Aldo Moro, Valenzano, Bari, Italy
    PLoS ONE 6:e27452. 2011
  9. ncbi Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl)phthalate (DEHP)
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstr 25 29, D 91054 Erlangen, Germany
    Int J Hyg Environ Health 207:15-22. 2004
  10. ncbi Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate
    Kirsten Jarfelt
    Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Reprod Toxicol 19:505-15. 2005

Detail Information

Publications349 found, 100 shown here

  1. pmc The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms
    Jerome N Feige
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    Environ Health Perspect 118:234-41. 2010
    ..b>Diethylhexyl phthalate (DEHP) is a widely used industrial plasticizer to which humans are widely exposed...
  2. ncbi Di(2-ethylhexyl)phthalate (DEHP): human metabolism and internal exposure-- an update and latest results
    H M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Androl 29:155-65; discussion 181-5. 2006
    ..Premature neonates (n = 45) were exposed to DEHP up to 100 times above the limit values depending on the intensity of medical care (median: 42 microg/kg/day; 95th percentile: 1,780 microg/kg/day)...
  3. ncbi Measurement of eight urinary metabolites of di(2-ethylhexyl) phthalate as biomarkers for human exposure assessment
    M J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Biomarkers 11:1-13. 2006
    ..6% (MEHP) and 31.8% (MECPP) in the adults. Whether the observed differences reflect differences in route/duration of the exposure, age and/or health status of the individuals is presently unknown...
  4. ncbi Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate
    Bethany R Hannas
    Toxicology Assessment Division, Reproductive Toxicology Branch, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:206-16. 2011
    ....
  5. pmc Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes
    Sandrine Ellero-Simatos
    INSERM, UMR 775, Universite Paris Descartes, Sorbonne Paris Cité, 45 Rue des Saints Peres, 75006 Paris, France
    J Proteome Res 10:5493-502. 2011
    ..Altogether, these results indicate that MEHP promoted the differentiation of human preadipocytes to adipocytes. These mechanisms might contribute to the suspected obesogenic effect of MEHP...
  6. ncbi A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
    Kembra L Howdeshell
    Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 105:153-65. 2008
    ..In the fetal rat, exposure to the phthalates benzylbutyl phthalate (BBP), di(n)butyl phthalate (DBP), and diethylhexyl phthalate (DEHP) decreases testicular testosterone production and insulin-like 3 hormone mRNA levels...
  7. pmc Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro
    François Chauvigné
    INSERM Institut National de la Santé et de la Recherche Médicale, U625, GERHM, Universite Rennes I, Campus de Beaulieu, Rennes, Bretagne, France
    Environ Health Perspect 117:515-21. 2009
    ..Nevertheless, their path of action, dose-response character, and cellular target(s) within the fetal testis are not known...
  8. pmc In vitro acute exposure to DEHP affects oocyte meiotic maturation, energy and oxidative stress parameters in a large animal model
    Barbara Ambruosi
    Department of Animal Production, University of Bari Aldo Moro, Valenzano, Bari, Italy
    PLoS ONE 6:e27452. 2011
    ....
  9. ncbi Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl)phthalate (DEHP)
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstr 25 29, D 91054 Erlangen, Germany
    Int J Hyg Environ Health 207:15-22. 2004
    ..To date no information on the biological activity and toxicity of oxidative metabolites of DEHP is available. Since these are the major metabolites of DEHP toxicological data on these metabolites is urgently needed...
  10. ncbi Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate
    Kirsten Jarfelt
    Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Reprod Toxicol 19:505-15. 2005
    ..However, no combination effect was seen with respect to antiandrogenic effects, as males receiving DEHP in combination with DEHA did not exhibit more pronounced effects in the reproductive system than males receiving DEHP alone...
  11. ncbi DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites
    R Hauser
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Reprod 22:688-95. 2007
    ....
  12. pmc Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor
    Hongzu Ren
    National Health and Environmental Effects Research Lab Toxicogenomics Core, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 113:45-59. 2010
    ..Our results indicate that exposure to PPARalpha activators including DEHP leads to activation of multiple nuclear receptors in the rodent liver...
  13. ncbi In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate
    Keita Kanki
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Mol Carcinog 42:9-17. 2005
    ..Our data also indicate that analysis of specific in vivo mutational responses with transgenic animal models can provide crucial information for understanding the molecular mechanisms underlying chemical carcinogenesis...
  14. pmc Effects of endocrine disruptors on imprinted gene expression in the mouse embryo
    Eun Rim Kang
    Department of Molecular and Cellular Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA
    Epigenetics 6:937-50. 2011
    ..Our data suggest that the maintenance of strongly biased monoallelic expression of imprinted genes is generally insensitive to EDs in the 13.5 dpc embryo and extra-embryonic organs, but is not immune to those effects...
  15. ncbi Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 78:123-30. 2004
    ..0 to 9.3. The excretion ratio of 5OH-MEHP to 5oxo-MEHP remained constant through time at 1.7 in the mean. After 44 h, 47% of the DEHP dose was excreted in urine, comprising MEHP (7.3%), 5OH-MEHP (24.7%) and 5oxo-MEHP (14.9%)...
  16. ncbi Metabolism of phthalates in humans
    Hanne Frederiksen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Mol Nutr Food Res 51:899-911. 2007
    ..This differential distribution is of special concern as, in particular, the hydrophobic phthalates and their metabolites are shown to have adverse effects following in utero and lactational exposures in animal studies...
  17. ncbi DEHP metabolites in urine of children and DEHP in house dust
    Kerstin Becker
    Umweltbundesamt Federal Environmental Agency, Berlin, Germany
    Int J Hyg Environ Health 207:409-17. 2004
    ..The house dust analyses revealed DEHP contamination of all samples. The GM was 508 mg/kg dust. No correlation could be observed between the levels of any of the urinary DEHP metabolites and those of DEHP in house dust...
  18. ncbi A biomarker approach to measuring human dietary exposure to certain phthalate diesters
    W A Anderson
    Ministry of Agriculture Fisheries and Food, Central Science Laboratory, Sand Hutton, York, UK
    Food Addit Contam 18:1068-74. 2001
    ..These conversion factors can be used in future studies to assess exposure to phthalate esters via measuring urinary levels of the monoester metabolites...
  19. ncbi Diethylhexyl phthalate impairs insulin binding and glucose oxidation in Chang liver cells
    Srinivasan Rengarajan
    Department of Endocrinology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    Toxicol In Vitro 21:99-102. 2007
    The present study examined the dose-dependent effects of diethylhexyl phthalate (DEHP) on insulin receptor concentration and glucose oxidation in Chang liver cells...
  20. ncbi Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice
    Jitka Stilund Hansen
    Airway Allergy and Irritation Group, National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Toxicology 232:79-88. 2007
    ..03 mg/m(3) MEHP observed in the present study and estimated human exposure levels...
  21. ncbi Changes in some hormones by low doses of di (2-ethyl hexyl) phthalate (DEHP), a commonly used plasticizer in PVC blood storage bags & medical tubing
    N S Gayathri
    Department of Biological Sciences, Research and Development, Terumo Penpol Limited, Thiruvananthapuram, India
    Indian J Med Res 119:139-44. 2004
    ....
  22. pmc Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium
    Nikki Gillum
    Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA
    Toxicol Appl Pharmacol 236:25-38. 2009
    ..The data indicate that DEHP, in clinically relevant concentrations, can impair the electrical and mechanical behavior of a cardiac cell network. Applicability of these findings to human patients remains to be established...
  23. pmc Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer Di(2-ethylhexyl) phthalate
    R W Moore
    School of Pharmacy, University of Wisconsin, 425 N Charter St, Madison, WI 53706, USA
    Environ Health Perspect 109:229-37. 2001
    ..These results suggest that DEHP acts partly by mechanisms distinct from those of other antiandrogens...
  24. pmc Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers
    Dana B Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 111:1148-51. 2003
    ....
  25. ncbi Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat
    Yi Lin
    Ministry of Education, Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Am J Physiol Endocrinol Metab 301:E527-38. 2011
    ..DEHP exposure in critical periods of development can be a potential risk factor, at least in part, for developing diabetes...
  26. ncbi Health risks posed by use of Di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review
    J A Tickner
    Lowell Center for Sustainable Production, Department of Work Environment, University of Massachusetts, Lowell, MA 01854, USA
    Am J Ind Med 39:100-11. 2001
    ..From the late 1960s, leaching of DEHP from PVC medical devices and ultimate tissue deposition have been documented...
  27. ncbi Effect of a hypolipidemic drug, Di (2-ethylhexyl) phthalate, on mRNA-expression associated fatty acid and acetate metabolism in rat tissues
    Ai Itsuki-Yoneda
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja shi, Okayama, Japan
    Biosci Biotechnol Biochem 71:414-20. 2007
    ..From these results, it is suggested that DEHP-treatment increased fatty acid oxidation and acetate formation in liver and testes, and that acetate utilization was increased in peripheral tissues such as the heart...
  28. ncbi The association between semen quality in workers and the concentration of di(2-ethylhexyl) phthalate in polyvinyl chloride pellet plant air
    Li Ping Huang
    Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan
    Fertil Steril 96:90-4. 2011
    ..To investigate potential associations between semen quality in workers and the concentrations of di(2-ethylhexyl) phthalate (DEHP) in personal air collected from polyvinyl chloride (PVC) plants...
  29. pmc Effects of di(2-ethylhexyl) phthalate (DEHP) on female fertility and adipogenesis in C3H/N mice
    Juliane Susanne Schmidt
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Halle Saale, Germany
    Environ Health Perspect 120:1123-9. 2012
    ..Exposure to DEHP has been linked with testicular impairment and male subfertility. However, the effects of DEHP on female reproductive health and metabolism have not been studied in detail...
  30. ncbi A twenty-volunteer study using deuterium labelling to determine the kinetics and fractional excretion of primary and secondary urinary metabolites of di-2-ethylhexylphthalate and di-iso-nonylphthalate
    Warwick A C Anderson
    The Food and Environment Research Agency, Sand Hutton, York, YO41 1LZ, UK
    Food Chem Toxicol 49:2022-9. 2011
    ..These robust fractional excretion values for the main primary and secondary phthalate metabolites along with estimates of their uncertainty can be used in future surveys of human exposure to DEHP and DINP...
  31. ncbi NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory, USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:529-653. 2002
  32. pmc Intra- and inter-individual variability of urinary phthalate metabolite concentrations in Hmong women of reproductive age
    Jennifer David Peck
    Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Expo Sci Environ Epidemiol 20:90-100. 2010
    ..g., metabolites of DEHP)...
  33. ncbi Effect of di(2-ethylhexyl) phthalate (DEHP) on lipolysis and lipoprotein lipase activities in adipose tissue of rats
    Marcela I Martinelli
    Departamento de Ciencias Biologicas, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina
    Hum Exp Toxicol 29:739-45. 2010
    ..More research is needed to achieve a comprehensive understanding of the potential mechanisms by which DEHP causes, among others, a reduced body fat retention...
  34. ncbi Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates
    Alexandre Eveillard
    Laboratoire de Pharmacologie et Toxicologie, Institut National de la Recherche Agronomique, INRA UR66, Toulouse, France
    Biochem Pharmacol 77:1735-46. 2009
    ..CAR-mediated effects of DEHP provide a new rationale for most endpoints of phthalates toxicity described previously, including endocrine disruption, hepatocarcinogenesis and the metabolic syndrome...
  35. pmc Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells
    Jinjiang Fan
    The Research Institute of the McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Room C10 148, Montreal, Quebec, Canada H3G 1A4
    Endocrinology 151:3348-62. 2010
    ..A model for the mechanism of MEHP action on MA-10 Leydig cell steroidogenesis is proposed...
  36. ncbi Phthalates and food-contact materials: enforcing the 2008 European Union plastics legislation
    J H Petersen
    National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:1608-16. 2010
    ..All findings of phthalates were associated with the use of plasticized polyvinylchloride (PVC)...
  37. ncbi Inhibitory effects of mono-ethylhexyl phthalate on steroidogenesis in immature and adult rat Leydig cells in vitro
    Konstantin Svechnikov
    Department of Woman and Child Health, Pediatric Endocrinology Unit, Q2 08, Karolinska Institute and University Hospital, SE 17176 Stockholm, Sweden
    Reprod Toxicol 25:485-90. 2008
    ..This may partly explain the anti-androgenic effects of DEHP in vivo and indicate a higher susceptibility in younger subjects...
  38. ncbi Effect of mono-ethylhexyl phthalate on MA-10 Leydig tumor cells
    J H Dees
    Division of Hormone Research, Department of of Cell Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Reprod Toxicol 15:171-87. 2001
    ..5-fold over control levels at MEHP concentrations of 10(-6) to 10(-3) M whereas mitochondrial volume fraction decreased. These results suggest that MEHP in Leydig cells may act as a mitochondrial toxicant and lipid metabolism disrupter...
  39. ncbi Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice
    Søren Thor Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicology 235:119-29. 2007
    ..Furthermore, studies in mice have demonstrated an adjuvant effect from DEHP after parenteral administration with the model allergen ovalbumin (OVA)...
  40. ncbi Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    L E Gray
    Endocrinology Branch, MD 72, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 58:350-65. 2000
    ..In summary, DEHP, BBP, and DINP all altered sexual differentiation, whereas DOTP, DEP, and DMP were ineffective at this dose. Whereas DEHP and BBP were of equivalent potency, DINP was about an order of magnitude less active...
  41. pmc Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 114:1783-9. 2006
    ..Although the vast and growing literature on phthalates research could not be covered comprehensively in this article, we made every attempt to include the most relevant publications as of the end of 2005...
  42. pmc DEHP impairs zebrafish reproduction by affecting critical factors in oogenesis
    Oliana Carnevali
    Department of Marine Sciences, Polytechnic University of Marche, Ancona, Italy
    PLoS ONE 5:e10201. 2010
    ..Since there is a significant genetic similarity between D.rerio and humans, the harmful effects observed at oocyte level may be relevant for further molecular studies on humans...
  43. ncbi The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis
    Jerome N Feige
    Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne, Switzerland
    J Biol Chem 282:19152-66. 2007
    ..These results highlight some key mechanisms in metabolic disruption but are also instrumental in the context of selective PPAR modulation, a promising field for new therapeutic development based on PPAR modulation...
  44. pmc Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 6635 SPH Tower, 109 S Observatory St, Ann Arbor, MI 48109, USA
    J Androl 30:287-97. 2009
    ..In conclusion, these results suggest that urinary metabolites of DEHP are inversely associated with circulating steroid hormone levels in adult men. However, additional research is needed to confirm these findings...
  45. ncbi The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats
    I Svechnikova
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute and University Hospital, Q2 08, 171 76 Stockholm, Sweden
    J Endocrinol 194:603-9. 2007
    ..Together, these data indicate that DEHP exerts dual effects on the pituitary-gonadal axis, stimulating the hormonal function of the pituitary and, at the same time, by inhibiting steroidogenesis by GCs...
  46. ncbi Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages
    Stephanie A Lahousse
    Division of Biological Sciences, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 93:369-81. 2006
    ..These data demonstrate that similar genetic targets are altered following fetal and prepubertal phthalate exposure, suggesting that the initial mechanism of fetal and prepubertal phthalate-induced testicular injury is shared...
  47. pmc Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 115:1029-34. 2007
    ..A limited number of animal studies suggest that exposure to phthalates may be associated with altered thyroid function, but human data are lacking...
  48. ncbi Associations between urinary phthalate monoesters and thyroid hormones in pregnant women
    Po Chin Huang
    Department of Environmental and Occupational Health, Medical College, National Cheng Kung Universitys, Tainan, Taiwan, Republic of China
    Hum Reprod 22:2715-22. 2007
    ..This study investigated the association between phthalate exposure and thyroid hormones in pregnant women...
  49. ncbi Preventive effect of D-psicose, one of rare ketohexoses, on di-(2-ethylhexyl) phthalate (DEHP)-induced testicular injury in rat
    Shigeru Suna
    Department of Hygiene and Public Health, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Toxicol Lett 173:107-17. 2007
    ..These results show that d-psicose prevents DEHP-induced testicular injury by suppressing the generation of ROS in the rat testis. This effect may be due to the direct scavenging by d-psicose of ROS generated in the testis...
  50. ncbi Effect of mono-(2-ethylhexyl) phthalate on bovine oocyte maturation in vitro
    Mohamed Kheir Idris Anas
    Department of Production Diseases, Theriogenology Section, National Institute of Animal Health, National Agricultural Research Organization, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Reprod Toxicol 17:305-10. 2003
    ....
  51. ncbi Mechanisms of toxicity of di(2-ethylhexyl) phthalate on the reproductive health of male zebrafish
    Tamsyn M Uren-Webster
    Hatherly Laboratories, School of Biosciences, University of Exeter, Exeter, Devon EX4 4PS, UK
    Aquat Toxicol 99:360-9. 2010
    ....
  52. ncbi A simple pharmacokinetic model to characterize exposure of Americans to di-2-ethylhexyl phthalate
    Matthew Lorber
    Office of Research and Development, United States Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC 20460, USA
    J Expo Sci Environ Epidemiol 20:38-53. 2010
    ....
  53. ncbi Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach
    Alexandre Eveillard
    Pôle de Toxicologie Alimentaire, Laboratoire de Pharmacologie et Toxicologie, Institut National de la Recherche Agronomique INRA UR66, Toulouse Cedex 3, France
    Toxicol Appl Pharmacol 236:282-92. 2009
    ..Altogether, this suggests that impacts of DEHP on adult organs, including testis, could be documented and deserve further investigations...
  54. ncbi DI-2-ethylhexyl phthalate and endocrine disruption: a review
    Giuseppe Latini
    Division of Pediatrics, Ospedale Perrino, Brindisi, University of Chieti, and 4Neonatal Intensive Care Unit, Azienda Ospedaliera Senese, Siena, Italy
    Curr Drug Targets Immune Endocr Metabol Disord 4:37-40. 2004
    ..In particular, certain members of this chemical class, such as di-[2-ethylhexyl]-phthalate (DEHP), have been shown to cause reproductive and developmental toxicity and are suspected to be endocrine disruptors...
  55. ncbi Phthalate treatment does not influence levels of IgE or Th2 cytokines in B6C3F1 mice
    John H Butala
    Toxicology Consultants, Gibsonia, PA, USA
    Toxicology 201:77-85. 2004
    ..In summary, treatment with DEHP, DINP, DIHP, and BBP did not result in significant elevations in total serum IgE, IL-4, or IL-13. As such it is unlikely that these substances would produce antibody-mediated respiratory allergy...
  56. ncbi Acetaminophen, pesticide, and diethylhexyl phthalate metabolites, anandamide, and fatty acids in deciduous molars: potential biomarkers of perinatal exposure
    David E Camann
    Analytical and Environmental Chemistry Department, Southwest Research Institute, San Antonio, TX 78228 0510, USA
    J Expo Sci Environ Epidemiol 23:190-6. 2013
    ..Validation studies are necessary to verify that each detected chemical in molars provides a biomarker of perinatal exposure...
  57. ncbi Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats
    Sofie Christiansen
    National Food Institute, Technical University of Denmark, Department of Toxicology and Risk Assessment, Søborg, Denmark
    Reprod Toxicol 30:313-21. 2010
    ..The results provide new evidence of low-dose effects of DEHP and are consistent with the EU NOAEL of 5 mg/kg for DEHP. Our results also indicate a reason for concern about human exposure to DEHP...
  58. ncbi Di-(2-ethylhexyl) phthalate induces severe aspermatogenesis in mice, however, subsequent antioxidant vitamins supplementation accelerates regeneration of the seminiferous epithelium
    Maira Ablake
    Department of Anatomy, Tokyo Medical University, Shinjuku 6 1 1, Shinjuku ku, Tokyo 160 8402, Japan
    Int J Androl 27:274-81. 2004
    ..However, the supplementation of antioxidant vitamins significantly accelerated regeneration of the injured seminiferous epithelium, suggesting that the vitamins have a therapeutic effect on DEHP-induced aspermatogenesis...
  59. ncbi Urinary oxidative metabolites of di(2-ethylhexyl) phthalate in humans
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Hwy NE, Atlanta, GA 30341, USA
    Toxicology 219:22-32. 2006
    ..Although quantitative information is not available, our findings suggest that, despite potential differences among species, the oxidative metabolism of DEHP in humans and rodents results in similar urinary metabolic products...
  60. pmc Alkyl phenols and diethylhexyl phthalate in tissues of sheep grazing pastures fertilized with sewage sludge or inorganic fertilizer
    Stewart M Rhind
    Macaulay Institute, Craigiebuckler, Aberdeen, United Kingdom
    Environ Health Perspect 113:447-53. 2005
    ..e., domestic ruminants) grazing such pasture...
  61. ncbi Mono-(2-ethylhexyl) phthalate (MEHP) induces spermatogenic cell apoptosis in guinea pig testes at prepubertal stage in vitro
    M A Awal
    Department of Anatomy and Histology, Bangladesh Agricultural University, Mymensingh, Bangladesh
    Int J Toxicol 23:349-55. 2004
    ..Because the loss of spermatogenic cells by MEHP treatment varies among species, the present study, using guinea pigs, was designed and conducted to obtain further information...
  62. ncbi Plasticizers, infant nutrition and reproductive health
    Giuseppe Latini
    Division of Neonatology, Ospedale A Perrino, s s 7 per Mesagne, 72100 Brindisi, Italy
    Reprod Toxicol 19:27-33. 2004
    ..Here, we report a review on dietary phthalate exposure in babies...
  63. ncbi Predicting residential exposure to phthalate plasticizer emitted from vinyl flooring: a mechanistic analysis
    Ying Xu
    Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, Virginia, USA
    Environ Sci Technol 43:2374-80. 2009
    ....
  64. ncbi Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei
    Takashi Tanida
    Laboratory of Functional Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1 1 Rokkodai, Nada Ku, Kobe 657 8501, Japan
    Toxicol Lett 189:40-7. 2009
    ..These results indicate that ED mixtures as pollution have unique and elusive effects. Thyroid hormones and/or aryl hydrocarbon receptor-related mechanisms may be responsible for this counteraction...
  65. ncbi Exposure of prepubertal female rats to inhaled di(2-ethylhexyl)phthalate affects the onset of puberty and postpubertal reproductive functions
    Mingyue Ma
    Department of Public Health, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Toxicol Sci 93:164-71. 2006
    ..These data suggest that inhaled DEHP may advance the onset of puberty and alter postpubertal reproductive functions...
  66. pmc Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage
    Harm de Waard
    MGC, Department of Cell Biology and Genetics, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 24:7941-8. 2004
    ..We suggest that the CSA and CSB proteins in part perform separate roles in different DNA damage response pathways...
  67. ncbi Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice
    Tomoko Matsuda
    Laboratory of Microbiology and Immunology, University of Shizuoka School of Pharmaceutical Sciences, Suruga ku, Shizuoka, Japan
    Toxicol Lett 192:97-100. 2010
    ..The results suggested that the combination of a hapten and a phthalate ester significantly affects the outcome of CHS...
  68. ncbi Di(2-ethylhexyl) phthalate induces a functional zinc deficiency during pregnancy and teratogenesis that is independent of peroxisome proliferator-activated receptor-alpha
    J M Peters
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Teratology 56:311-6. 1997
    ..In addition, this work suggests that DEHP-induced alterations in Zn metabolism contribute to the mechanisms underlying DEHP-induced reproductive toxicity and teratogenicity...
  69. ncbi An ultrastructural study on the effects of mono(2-ethylhexyl) phthalate on mice testes: cell death and sloughing of spermatogenic cells
    Tat Wei Tay
    Department of Veterinary Anatomy, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    Okajimas Folia Anat Jpn 83:123-30. 2007
    ..Sloughed and shed spermatogenic cells found in the tubular lumen were identified to be necrotic and apoptotic in appearance, respectively...
  70. pmc Di (2-ethylhexyl) phthalate inhibits growth of mouse ovarian antral follicles through an oxidative stress pathway
    Wei Wang
    Department of Comparative Biosciences, University of Illinois, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Toxicol Appl Pharmacol 258:288-95. 2012
    ..Collectively, these data suggest that DEHP inhibits follicle growth by inducing production of ROS and by decreasing the expression and activity of SOD1...
  71. ncbi Emission of di-2-ethylhexyl phthalate from PVC flooring into air and uptake in dust: emission and sorption experiments in FLEC and CLIMPAQ
    Per Axel Clausen
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen O, Denmark
    Environ Sci Technol 38:2531-7. 2004
    ..About one-half of the emitted DEHP was deposited on the internal surfaces of both the FLEC and the CLIMPAQ...
  72. ncbi Chronic toxicity of di(2-ethylhexyl)phthalate in mice
    R M David
    Health and Environment Laboratories, Eastman Kodak Company, 1100 Ridgeway Ave, Rochester, New York 14652 6272, USA
    Toxicol Sci 58:377-85. 2000
    ..7-6.8-fold higher than controls. Many lesions observed in rats were not seen in mice. A dose level of 500 ppm (98.5-116.8 mg/kg/day) was identified as a no-observed-adverse-effect level (NOAEL) for noncarcinogenic effects...
  73. pmc In utero exposure to the antiandrogen di-(2-ethylhexyl) phthalate decreases adrenal aldosterone production in the adult rat
    Daniel B Martinez-Arguelles
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA
    Biol Reprod 85:51-61. 2011
    ..Moreover, these results suggest the existence of a DEHP-sensitive adrenal-testis axis regulating androgen formation...
  74. ncbi Two generation reproductive and developmental toxicity following subchronic exposure of pubescent male mice to di(2-ethylhexyl)phthalate
    Małgorzata M Dobrzyńska
    Department of Radiation Protection and Radiobiology, National Institute of Public Health, Warsaw, Poland
    Ann Agric Environ Med 19:31-7. 2012
    ..The results may suggest that diminished spermaozoa quality induced by DEHP may be coincidental with mutations leading to intrauterine deaths and skeletal abnormalities in the offspring...
  75. pmc In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy
    Giuseppe Latini
    Neonatal Intensive Care Unit, Division of Paediatrics, Perrino Hospital, Brindisi, Italy
    Environ Health Perspect 111:1783-5. 2003
    ..50, 95% CI, 1.013-2.21; p = 0.043). These findings confirm that human exposure to DEHP can begin in utero and suggest that phthalate exposure is significantly associated with a shorter pregnancy duration...
  76. ncbi Di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in media for in vitro fertilization
    Satoshi Takatori
    Department of Food, Drugs and Environment, Osaka Prefectural Institute of Public Health, 1 3 69 Nakamichi, Higashinari ku, Osaka 537 0025, Japan
    Chemosphere 86:454-9. 2012
    ..The concentrations of DEHP and MEHP in PS were <10-982 and 47.0-1840 ng mL(-1), respectively. The DEHP and MEHP detected in these media were derived from PS. This is the first study on the chemical contamination of IVFM, SWM, and PS...
  77. ncbi [Estimation of intake level of di (2-ethyhexyl) phthalate (DEHP) in Japanese pregnant women based on measurement of concentrations of three urinary metabolites]
    Kayumi Fujimaki
    Institute of Environmental Studies, University of Tokyo, Tokyo, Japan
    Nihon Eiseigaku Zasshi 61:340-7. 2006
    ..corrected] The daily intake level of di (2-ethyhexyl) phthalate (DEHP) of Japanese pregnant women was estimated on the basis of the measurement of the urinary concentrations of three DEHP metabolites...
  78. ncbi An exposure assessment of di-(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in human semen
    Sang Won Han
    Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, South Korea
    J Toxicol Environ Health A 72:1463-9. 2009
    ..These findings suggest the detection of phthalates in healthy human semen might require further investigation for effects on human fertility...
  79. ncbi [Levels of environmental endocrine disruptors in umbilical cord blood and maternal blood of low-birth-weight infants]
    Ling Lin
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China
    Zhonghua Yu Fang Yi Xue Za Zhi 42:177-80. 2008
    ..To monitor the biological levels of environmental endocrine disruptors (EDs, phthalates and surfactants) in the umbilical cord blood and maternal blood of low-birth-weight infants...
  80. ncbi Migration of diethylhexyl phthalate from PVC bags into intravenous cyclosporine solutions
    M A Gotardo
    Departamento de Farmacos e Medicamentos, Faculdade de Ciencias Farmaceuticas, UNESP, CP 502, CEP 14801 902 Araraquara, Sao Paulo, Brazil
    J Pharm Biomed Anal 38:709-13. 2005
    The migration of diethylhexyl phthalate (DEHP) from PVC bags into LVPS (0.9% NaCl) and LVPS with cyclosporine at concentrations of 2.5 and 0.5mg/ml was studied...
  81. ncbi Hepatic peroxisome proliferator-activated receptor α may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice
    Yumi Hayashi
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Toxicology 289:1-10. 2011
    ..Taken together, PPARα expression is required for the toxicity of DEHP in fetuses and pups and altered plasma triglyceride levels, through regulation of MTP may be important in mPPARα mice and not in hPPARα mice...
  82. ncbi HPLC with diode-array detection for the simultaneous determination of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in seminal plasma
    Pietro Mazzeo
    Dipartimento di Chimica, Ingegneria Chimica e Materiali, Universita di L Aquila, Via Vetoio, 67010 Coppito, L Aquila, Italy
    Biomed Chromatogr 21:1166-71. 2007
    ..The limits of detection were 0.010 and 0.015 microg/mL, for DEHP and MEHP, respectively. This method was used to analyze real samples in support of clinical studies on these potential endocrine disruptors...
  83. ncbi Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats
    Jung D Park
    Center for Environmental and Occupational Health, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Toxicology 171:105-15. 2002
    ..Pathological lesions and apoptosis occurred prior to the loss of zinc in testis, suggesting that zinc depletion might be a secondary effect of DEHP-induced testicular toxicity, rather than the cause...
  84. ncbi In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice
    Francesca Maranghi
    Department of Food Safety and Veterinary Public Health, Veterinary and Food Toxicology Unit Istituto Superiore di Sanità, Rome, Italy
    Reprod Toxicol 29:427-32. 2010
    ..Our findings suggested that DEHP alters post-natal liver development delaying the programming of glycogen metabolism...
  85. ncbi Altered expression of genes related to zinc homeostasis in early mouse embryos exposed to di-2-ethylhexyl phthalate
    Jongwha Lee
    Department of Environmental Health Science, Soonchunhyang University, Choongchungnam do, Asan Si, Republic of Korea
    Toxicol Lett 152:1-10. 2004
    ..9 mg/kg for MT-II, and 6.6 mg/kg for ZnT-1. We conclude that DEHP exposure to pregnant dams at reasonably low levels during organogenesis stages can alter the expression of several key genes in embryonic zinc homeostasis...
  86. ncbi Short-term effects of di-(2-ethylhexyl) phthalate on testes, liver, kidneys and pancreas in mice
    Yumi Miura
    Department of Anatomy, Tokyo Medical University, Shinjuku ku, Tokyo 160 8402, Japan
    Asian J Androl 9:199-205. 2007
    ..To determine the biochemical effect of di-(2-ethylhexyl) phthalate (DEHP) on testes, liver, kidneys and pancreas on day 10 in the process of degeneration of the seminiferous epithelium...
  87. ncbi Environmental and experimental exposure of phthalate esters: the toxicological consequence on human sperm
    N Pant
    Indian Institute of Toxicology Research, Lucknow, Council of Scientific and Industrial Research, New Delhi, India
    Hum Exp Toxicol 30:507-14. 2011
    ..There are a significant correlation between phthalate ester diethylhexyl phthalate, di-n-butyl phthalate (DEHP and DBP) and sperm motility both in vitro and in vivo conditions...
  88. ncbi Endocrine disrupting effect of di-(2-ethylhexyl)phthalate on female rats and proteome analyses of their pituitaries
    Narumi Hirosawa
    Department of Biomedical Research Center, Division of Analytical Science, Saitama Medical School, Saitama, Japan
    Proteomics 6:958-71. 2006
    ..Reduction of gonadotrophin release in the pituitary seems to lead to a decrease of serum estradiol level and continuous diestrous stage in estrous cyclicity...
  89. ncbi Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquitinylation, and sensitivity of GC-2spd (ts) cells to undergo FAS-mediated apoptosis
    Yamini Chandrasekaran
    College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712 0125, USA
    Biol Reprod 74:560-8. 2006
    ....
  90. ncbi Effects of di-(2-ethylhexyl) phthalate and four of its metabolites on steroidogenesis in MA-10 cells
    Carlie D Piché
    Department of Chemical Engineering, McGill University, 3610 University Street, Montreal, QC, Canada H3A 2B2
    Ecotoxicol Environ Saf 79:108-15. 2012
    ..Overall, the study suggests the involvement of multiple active metabolites in the testicular toxicity of DEHP...
  91. ncbi DEHP: genotoxicity and potential carcinogenic mechanisms-a review
    Jane C Caldwell
    National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Washington, DC 20460, USA
    Mutat Res 751:82-157. 2012
    ....
  92. ncbi Probabilistic risk characterization: an example with di(2-ethylhexyl) phthalate
    Sieto Bosgra
    National Institute of Public Health and the Environment RIVM, NL 3720 BA Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 43:104-13. 2005
    ..This information leads to a better informed conclusion on the risk of a substance, and may be very useful to define the necessary measures for risk reduction...
  93. ncbi Activation of PPARalpha and PPARgamma by environmental phthalate monoesters
    Christopher H Hurst
    Department of Biology, Division of Cell and Molecular Biology, Boston University, Boston, Massachusetts 02215, USA
    Toxicol Sci 74:297-308. 2003
    ....
  94. ncbi Synthesis of DEHP metabolites as biomarkers for GC-MS evaluation of phthalates as endocrine disrupters
    Francesca Nuti
    Laboratory of Peptide and Protein Chemistry and Biology, Department of Organic Chemistry, University of Florence and CNR ICCOM, Polo Scientifico, Via della Lastruccia 13, I 50019 Sesto Fiorentino, Firenze, Italy
    Bioorg Med Chem 13:3461-5. 2005
    ..The metabolites of DEHP were synthesized, for the first time, as biomarkers to verify their quantitative determination in human urine and serum by GC-MS analysis for studying the exposure to phthalates and establishing reference values...
  95. ncbi Deregulation of the Sod1 and Nd1 genes in mouse fetal oocytes exposed to mono-(2-ethylhexyl) phthalate (MEHP)
    Edmundo Bonilla
    Department of Cell Proliferation and Development, Centro de Investigaciones Biologicas, C S I C, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Reprod Toxicol 30:387-92. 2010
    ..Indeed, functional assays on somatic cells transfected with a Sod1 luciferase reporter construct demonstrated its specific MEHP dose-dependent up-regulation, confirming that the expression of this gene is deregulated in response to MEHP...
  96. ncbi Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells
    Pinar Erkekoglu
    INAC SCIB LAN, CEA de Grenoble, 17 rue des Martyrs, 38054 Grenoble, France
    Free Radic Biol Med 49:559-66. 2010
    ....
  97. pmc Gene expression profiling of DEHP-treated cardiomyocytes reveals potential causes of phthalate arrhythmogenicity
    Nikki Gillum Posnack
    The Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA
    Toxicology 279:54-64. 2011
    ..We have recently reported that clinically relevant concentrations of DEHP can affect electrical coupling between cardiac myocytes causing significant rhythm disturbances. The underlying causes for this effect are currently unknown...
  98. ncbi Effect of mono-(2-ethylhexyl) phthalate (MEHP) on resumption of meiosis, in vitro maturation and embryo development of immature mouse oocytes
    A Dalman
    Department of Embryology, Cell Science Research Center, Royan Institute, ACECR, Tehran, Iran
    Biofactors 33:149-55. 2008
    ..05). These results indicate that MEHP could negatively modulate mouse oocyte meiotic maturation in vitro and embryo development, suggesting possible risks for human and other mammalians reproductive health...
  99. ncbi Dietary di(2-ethylhexyl)phthalate-impaired glucose metabolism in experimental animals
    Marcela I Martinelli
    Departamento de Ciencias Biologicas, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina
    Hum Exp Toxicol 25:531-8. 2006
    ..levels of this group, could indicate that DEHP-fed rats could present a deficiency in muscle glucose and lactate transport, a reduction of the flux through muscle hexokinase and hepatic glucokinase, and a reduction in glycogen synth-..
  100. ncbi The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells
    Akira Takeshita
    Endocrine Center, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, 2 2 2 Toranomon, Minato, Tokyo 105 8470, Japan
    J Endocrinol 190:897-902. 2006
    ..b>Diethylhexyl phthalate (DEHP) is widely used as a plasticizer for polyvinyl chloride (PVC) medical devices...
  101. ncbi Effect of mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells
    Jochen Reinsberg
    Department of Gynecological Endocrinology and Reproductive Medicine, University of Bonn, Germany
    Toxicol Appl Pharmacol 239:116-23. 2009
    ..As the in vitro effective doses of MEHP are within the range of real environmental exposure levels an inhibitory effect on estrogen production in vivo seems to be possible...

Research Grants48

  1. Transgenerational effects of endocrine disruptors: epigenetics and physiology
    Rebecca A Simmons; Fiscal Year: 2013
    ..The proof of the principle of prenatal programming by environmental contaminants may change our awareness of critical assessment of the risk of such compounds. ..
  2. AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPT
    Kassim Traore; Fiscal Year: 2013
    ..Publications that will rise from the proposed project could lead to a paradigm shift in how potential environmental chemicals and pharmaceutical drugs are evaluated. ..
  3. Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes
    Russ B Hauser; Fiscal Year: 2013
    ..abstract_text> ..
  4. Mechanisms of Inflammatory Lung Disease in Neonates
    BARRY I WEINBERGER; Fiscal Year: 2010
    ..The proposed studies will address this need, suggesting ways to decrease the incidence of BPD and other adverse outcomes that result from inflammation in newborns. ..
  5. Phthalates in Drugs and Male Genital Malformation
    Allen A Mitchell; Fiscal Year: 2012
    ....
  6. The Infant Development and the Environmental Study (TIDES)
    Shanna H Swan; Fiscal Year: 2013
    ..In rodents, diethylhexyl phthalate (DEHP) and dibutyl phthalate (DBP) induce a spectrum of male genital tract disorders termed the "phthalate ..
  7. Endocrine disrupting chemicals and ovotoxicity
    Jodi A Flaws; Fiscal Year: 2013
    ..preliminary studies indicate that a model organochlorine pesticide (methoxychlor;MXC), model phthalates (diethylhexyl phthalate;DEHP and mono (2-ethyl-5-hydroxyhexyl) phthalate;MEHP), and bisphenol A (BPA) reduce E2 levels and destroy ..
  8. Epigenetic Reprogramming in Germline by Phthalates
    Kwan Hee Kim; Fiscal Year: 2013
    ..This investigation has the potential to impact our thinking on the fetal exposure to environmental toxins and the adult onset and progression of human familial diseases. ..
  9. The effect of phthalates on the heart: molecular pathways and clinical relevance
    Nikki Gillum Posnack; Fiscal Year: 2013
    ..In contrast, little is known about the adverse effects of DEHP on the heart, and awareness of its potential cardiotoxicity is essentially non-existent. ..
  10. Early-life phthalate exposure, thyroid function and child cognitive development
    ROBIN MARJORIE WHYATT; Fiscal Year: 2013
    ....
  11. Sertoli cell injury and mechanisms of testicular germ cell apoptosis
    John H Richburg; Fiscal Year: 2013
    ..In the last aim, experiments are focused on revealing the mechanisms regulating the levels of the c-FLIP protein and its role in altering the sensitivity of germ cell sub-types to undergo FasL-triggered apoptosis. ..
  12. Assessing transgenerational effects of Phthalates on primordial germ cells
    Diana J Laird; Fiscal Year: 2013
    ..The proposed work is significant as it will determine the extent to which phthalate exposure alters reprogramming in PGCs and potentially identify candidate mechanisms of transgenerational epigenetic inheritance. ..
  13. Genomic and Proteomic Biomarkers of Biological Responses to Exposure
    CORAL LAMARTINIERE; Fiscal Year: 2010
    ..In the rats, we will also measure genes and proteins in the mammary glands as a function of exposure and puberty to gain insight into how environmental chemical exposure early in life predisposes for breast cancer later in life. ..
  14. Combinational Environmental Chemicals Altering Susceptibility for Mammary Cancer
    Jose Russo; Fiscal Year: 2013
    ....
  15. Epigenetic Changes After Intrauterine Exposure to Endocrine Disrupting Chemicals
    KARIN MICHELS; Fiscal Year: 2009
    ....
  16. Effect of chronic low-dose phthalate exposure on the immature primate testis
    Ina Dobrinski; Fiscal Year: 2009
    ....
  17. ISOLATION OF ELONGATION ENZYMES & SITE OF SYNTHESIS
    DOMINICK CINTI; Fiscal Year: 1991
    ..Insights into these proposed aims will provide significant contributions to our fundamental understanding of lipid metabolism...
  18. LIPID METABOLISM AND PHTHALATE TOXICITY INTERACTIONS
    James Swenberg; Fiscal Year: 1999
    ....
  19. Action of an endocrine disruptor on the Leydig cell
    Matthew Hardy; Fiscal Year: 2007
    ..data will facilitate identification of biomarkers of exposure to environmental pollutants, and provide information to regulatory agencies in setting limits for the use of DEHP and phthalates in consumer products [unreadable] [unreadable]..
  20. Fetal Origin of Male Reproductive Disorders
    Vassilios Papadopoulos; Fiscal Year: 2009
    ....
  21. MECHANISM OF TOXICANT INDUCED INJURY IN NEONATAL TESTES
    Joanne Orth; Fiscal Year: 2002
    ..In the long term, the findings will improve the investigator's ability to safeguard developing human males from the risks of exposure to the these toxicants. ..
  22. Phthalate-induced testicular mitochondrial dysfunction
    THOMAS ONORATO; Fiscal Year: 2005
    ..Mechanistic studies involving state of the art molecular cell biology techniques will be used to elucidate the role that mitochondrial dysfunction plays in phthalate-induced testicular toxicity and infertility. ..
  23. Cisplatin and Mechanisms of Long-term Male Infertility
    JOHN RICHBURG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. ENVIRONMENTAL TESTICULAR TOXICITY & GERM CELL APOPTOSIS
    JOHN RICHBURG; Fiscal Year: 2004
    ..This investigation of MEHP-stimulated germ cell apoptosis will provide fundamental insights into mechanisms regulating the sensitivity of germ cell to undergo apoptosis after chemical-induced testicular injury. ..
  25. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    JOHN RICHBURG; Fiscal Year: 2006
    ....
  26. Environmental Endocrine Disrupters 2008 Gordon Research Conference
    Shanna Swan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  27. US STUDY OF SEMEN QUALITY IN PARTNERS OF PREGNANT WOMEN
    Shanna Swan; Fiscal Year: 2001
    ....
  28. DNA REPAIR AND SUSCEPTIBILITY TO ENVIRONMENTAL AGENTS
    Ivan Rusyn; Fiscal Year: 2004
    ..These experiments will also provide crucial mechanistic insights into possible differences in species- and tissue-specific responses to DNA damage induced by environmental agents. ..
  29. Molecular Mechanisms of Phthalate-induced Carcinogenesis
    Ivan Rusyn; Fiscal Year: 2007
    ..This results in a "potentiation" of a non-specific mitogen release from Kupffer cells activated by lipid-like peroxisome proliferator particles, thus accounting for a characteristic burst of proliferation in the liver. ..
  30. Metabolomic and Toxicogenetic Study of Ethanol Toxicity
    Ivan Rusyn; Fiscal Year: 2009
    ..abstract_text> ..
  31. Maternal Phthalate Exposure and Infertility, Fetal Loss
    Russ Hauser; Fiscal Year: 2007
    ..Since occupational and environmental exposure to phthalates is widespread, detecting even small adverse effects will have large public health significance. ..
  32. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2009
    ..Since the etiology of infertility and early pregnancy loss remains largely unexplained, the identification of potential environmental risk factors will have large public health significance. ..
  33. Validation of biomarkers of prenatal pesticides exposure
    Robin Whyatt; Fiscal Year: 2003
    ....
  34. PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53
    Kim Boekelheide; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  35. ENVIRONMENTAL/INDUSTRIAL TOXICANTS AND TESTICULAR INJURY
    Kim Boekelheide; Fiscal Year: 2003
    ..Together, these complimentary approaches will elucidate the key molecular mechanisms responsible for irreversible testicular injury. ..
  36. ENVIRONMENTAL EPOXIDES--MECHANISMS OF OVOTOXICITY
    Patricia Hoyer; Fiscal Year: 2002
    ..The results of these studies will provide greater insight as to the impact of exposure to ovotoxic environmental chemicals on reproductive health in women. ..
  37. SERTOLI CELL TOXICITY IN VIVO--MICROTUBULE DISRUPTION
    Kim Boekelheide; Fiscal Year: 2001
    ..Together, these complimentary approaches will critically examine key steps in the pathogenetic sequence by which microtubule disrupters alter the supportive capacity of Sertoli cells resulting in loss of germ cells and infertility. ..
  38. Exploration of ETS Effects on Child Behavior and Sleep
    Kimberly Yolton; Fiscal Year: 2005
    ..abstract_text> ..
  39. Bridge to the Doctorate at UMET: Building the Next Gene*
    Beatriz Zayas; Fiscal Year: 2005
    ..Thus, for the duration of the project a grand total of 540 students will benefit from these development activities and will learn more about graduate studies in biomedical sciences. ..
  40. Prenatal Insecticide Exposures Among Urban Minorities
    Robin Whyatt; Fiscal Year: 2005
    ..The research will provide important information about pesticide exposure during pregnancy among this minority cohort. ..
  41. Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood
    Kimberly Yolton; Fiscal Year: 2010
    ....
  42. Novel Approaches to Studying the Situ Bioremediation of Complex Mixtures
    ROLF HALDEN; Fiscal Year: 2009
    ..abstract_text> ..
  43. Aging and Function of Stem Leyding Cells
    Ren Shan Ge; Fiscal Year: 2010
    ....
  44. Phthalate Exposure and Pregnancy Outcome
    T Peter Stein; Fiscal Year: 2010
    ..The findings will have ramifications for public health, for the packaging trade and for the chemical industry. ..
  45. Ovary Intact Murine Model for Menopause
    Patricia Hoyer; Fiscal Year: 2007
    ..Characterization of the VCD-treated mouse will, therefore, make a profound contribution to the study of menopause-related pathologies and, therefore, to women's health. ..
  46. SIGNALING PATHWAYS IN CHEMICAL INDUCED OVOTOXICITY
    Patricia B Hoyer; Fiscal Year: 2010
    ..This will lead to an appreciation of the global impact of the environment on the reproductive life span in women. ..