Genomes and Genes
Summary: A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)
Publications262 found, 100 shown here
- Temporal variability of urinary phthalate metabolite levels in men of reproductive ageRuss Hauser
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 112:1734-40. 2004..In particular, a single urine sample was most predictive for MEP and least predictive for MEHP. These results suggest that the most efficient exposure assessment strategy for a particular study may depend on the phthalates of interest...
- Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000Manori J Silva
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
Environ Health Perspect 112:331-8. 2004....
- Prenatal phenol and phthalate exposures and birth outcomesMary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Environ Health Perspect 116:1092-7. 2008..Many phthalates and phenols are hormonally active and are suspected to alter the course of development...
- Prenatal exposure to phthalate esters and PAHs and birth outcomesYayoi Suzuki
Department of Environmental Studies, University of Tokyo, Chiba, Japan
Environ Int 36:699-704. 2010..In conclusion, we found that prenatal exposure to phthalate esters or PAHs did not affect birth outcomes at the exposure level of the present subjects...
- Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002Elizabeth E Hatch
Department of Epidemiology, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA
Environ Health 7:27. 2008..Although diet and activity are key factors in the obesity epidemic, laboratory studies suggest that endocrine disrupting chemicals may also affect obesity...
- Associations between phthalate metabolite urinary concentrations and body size measures in New York City childrenSusan L Teitelbaum
Mount Sinai School of Medicine, Department of Preventive Medicine, One Gustave L Levy Place, Box 1057, NY 10029, USA
Environ Res 112:186-93. 2012..To examine prospectively associations between urinary phthalate metabolite concentrations and body size measures in children...
- What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?Matthias Wormuth
Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland
Risk Anal 26:803-24. 2006..The scenario-based approach chosen in the present study provides a link between the knowledge on emission sources of phthalates and the concentrations of phthalate metabolites found in human urine...
- Prenatal phthalate exposure is associated with childhood behavior and executive functioningStephanie M Engel
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Environ Health Perspect 118:565-71. 2010..Experimental and observational studies have reported biological consequences of phthalate exposure relevant to neurodevelopment...
- Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. malesRichard W Stahlhut
Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Environ Health Perspect 115:876-82. 2007..Low testosterone in adult human males has been associated with increased prevalence of obesity, insulin resistance, and diabetes...
- Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United StatesS L Teitelbaum
Mount Sinai School of Medicine, Department of Community and Preventive Medicine, 1 Gustave Levy Place, P O Box 1043, New York, NY 10029, USA
Environ Res 106:257-69. 2008..However, reliability in the use of these biomarkers requires an understanding of the timeframe of exposure represented by one measurement. Data on the temporal variability of ED biomarkers are sparse, especially among children...
- Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of ageRobin M Whyatt
Department of Environmental Health Sciences, Columbia Center for Children s Environmental Health Department of Environmental Health Sciences, Mailman School of Public Health, 722 West 168th St, New York, NY 10032 USA
Environ Health Perspect 120:290-5. 2012..Research suggests that prenatal phthalate exposures affect child executive function and behavior...
- Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008John D Meeker
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Environ Health Perspect 119:1396-402. 2011..Limited animal, in vitro, and human studies have reported that exposure to phthalates or bisphenol A (BPA) may affect thyroid signaling...
- Phthalate exposure and pulmonary functionJane A Hoppin
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, PO Box 12233, Research Triangle Park, NC 27709 2233, USA
Environ Health Perspect 112:571-4. 2004..Our results suggest that MBP and MEP, but not MEHP, may influence pulmonary function among adult males...
- Phthalate exposure in pregnant women and their children in central TaiwanSusana Lin
National Health Research Institutes, Taiwan
Chemosphere 82:947-55. 2011..The level of phthalate metabolites in milk and cord blood were comparable to those found in other populations. Further studies of health effects related to DEHP and DiNP exposure are necessary for the children...
- Reproductive toxicity of phthalate estersAnderson Joel Martino-Andrade
Universidade Federal do Parana, Departamento de Fisiologia, Curitiba, Brazil
Mol Nutr Food Res 54:148-57. 2010..Finally, we point out some critical issues that should be addressed in order to clarify the implications of phthalates for human reproduction...
- Phthalate exposure associated with self-reported diabetes among Mexican womenKatherine Svensson
Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, USA
Environ Res 111:792-6. 2011..This exploratory cross-sectional study evaluated the possible association between phthalate exposure and self-reported diabetes among adult Mexican women...
- Phthalates: toxicology and exposureUrsel Heudorf
Public Health Department of the City of Frankfurt, Germany
Int J Hyg Environ Health 210:623-34. 2007..However, health concern is raised regarding the developmental and/or reproductive toxicity of phthalates, even in environmental concentrations...
- Phthalates in cosmetic and personal care products: concentrations and possible dermal exposureDiane Koniecki
Cosmetics Division, Health Canada, Ottawa, Canada
Environ Res 111:329-36. 2011..03 μg/kg bw/d). The exposure for DiBP was not calculated due to its very low levels (<10 μg/g) in products. Toddlers and infants in this case had a maximal daily exposure to DEP of 20 and 42 μg/kg bw/d, respectively...
- Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humansShanna H Swan
Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 668, Rochester, NY 14642, USA
Environ Res 108:177-84. 2008..Replication of the results described here and further mechanistic studies are needed to strengthen links between phthalates and adverse health outcomes...
- Variability and predictors of urinary bisphenol A concentrations during pregnancyJoe M Braun
Department of Environmental Health, Harvard University, Boston, Massachusetts, USA
Environ Health Perspect 119:131-7. 2011..Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy...
- Association of endocrine disruptors and obesity: perspectives from epidemiological studiesE E Hatch
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
Int J Androl 33:324-32. 2010..As this field of research advances, there are challenging methodological questions that must be considered by both epidemiologists and toxicologists...
- Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girlsMary S Wolff
Mount Sinai School of Medicine, New York, NY 10029, USA
Environ Health Perspect 118:1039-46. 2010..Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by steroids and gonadotropins...
- Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary interventionRuthann A Rudel
Silent Spring Institute, Newton, Massachusetts 02458, USA
Environ Health Perspect 119:914-20. 2011..They have been associated with endocrine disruption in animals and in some human studies. Human exposure sources have been estimated, but the relative contribution of dietary exposure to total intake has not been studied empirically...
- Consumer product exposures associated with urinary phthalate levels in pregnant womenJessie P Buckley
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
J Expo Sci Environ Epidemiol 22:468-75. 2012..Although personal care product use may be an important predictor of urinary phthalate levels, most of the variability in phthalate exposure was not captured by our relatively comprehensive set of questionnaire items...
- Urinary phthalate metabolite concentrations and diabetes among women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008Tamarra James-Todd
Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont St, Division of Women s Health, 3rd Floor, Boston, MA 02120, USA
Environ Health Perspect 120:1307-13. 2012..Few studies have evaluated the association between phthalate metabolites, diabetes, and diabetes-related risk factors among women...
- Prenatal exposure to butylbenzyl phthalate and early eczema in an urban cohortAllan C Just
Columbia Center for Children s Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 120:1475-80. 2012..Recent cross-sectional studies suggest a link between butylbenzyl phthalate (BBzP) in house dust and childhood eczema...
- Human body burdens of chemicals used in plastic manufactureHolger M Koch
BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Bochum, Germany
Philos Trans R Soc Lond B Biol Sci 364:2063-78. 2009..We discuss several factors relevant for interpreting and understanding biomonitoring data, including selection of both biomarkers of exposure and human matrices, and toxicokinetic information...
- Phthalate exposure and asthma in childrenC G Bornehag
Public Health Sciences, Karlstad University, Karlstad, Sweden
Int J Androl 33:333-45. 2010..But the important questions of clinical relevance of real life exposure and identification of molecular targets that can explain interactions largely remain to be answered...
- Prenatal phthalate exposure and reduced masculine play in boysS H Swan
Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA
Int J Androl 33:259-69. 2010..Our findings suggest that these ubiquitous environmental chemicals have the potential to alter androgen-responsive brain development in humans...
- PVC flooring is related to human uptake of phthalates in infantsF Carlstedt
Primary Care Research Unit, County Council of Varmland, Karlstad, Sweden
Indoor Air 23:32-9. 2013..Urinary levels of phthalate metabolites during early life are associated with the use of PVC flooring in the bedroom, body area, and the use of infant formula...
- Phthalate levels and low birth weight: a nested case-control study of Chinese newbornsYunhui Zhang
Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
J Pediatr 155:500-4. 2009..To assess maternal-fetal exposure to phthalates and investigate whether in utero phthalate exposure is associated with low birth weight (LBW)...
- Exposure to phthalates: reproductive outcome and children health. A review of epidemiological studiesJoanna Jurewicz
Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland
Int J Occup Med Environ Health 24:115-41. 2011..Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented...
- Urinary excretion of phthalates and paraben after repeated whole-body topical application in humansNadeem Rezaq Janjua
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Int J Androl 31:118-30. 2008..The three chemicals are systemically absorbed, metabolized and excreted in urine following application on the skin in a cream preparation. More DEP than DBP was absorbed, presumably because of a faster absorption rate for DEP...
- Internal phthalate exposure over the last two decades--a retrospective human biomonitoring studyMatthias Wittassek
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Germany
Int J Hyg Environ Health 210:319-33. 2007....
- Human exposure to phthalates via consumer productsTed Schettler
Science and Environmental Health Network, Newburyport, MA, USA
Int J Androl 29:134-9; discussion 181-5. 2006..Oven baking of polymer clays may cause short-term, high-level inhalation exposures to higher molecular weight phthalates...
- Phthalates: metabolism and exposureMatthias Wittassek
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Erlangen, Germany
Int J Androl 31:131-8. 2008..Therefore, the concept of a cumulative TDI value may be more appropriate for the consideration of the overall exposure and the potential human health risks resulting from everyday and simultaneous exposure to several phthalates...
- An assessment of the ability of phthalates to influence immune and allergic responsesIan Kimber
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
Toxicology 271:73-82. 2010....
- Phthalate metabolites in urine from China, and implications for human exposuresYing Guo
Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
Environ Int 37:893-8. 2011..S. Environmental Protection Agency...
- Associations between maternal phthalate exposure and cord sex hormones in human infantsLung Cheng Lin
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Chemosphere 83:1192-9. 2011..We suggest that maternal exposure to phthalates may affect sex steroid hormones status in fetal and newborn stage...
- Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children -- A comparison of two estimation models based on urinary DEHP metabolite levelsMatthias Wittassek
Institute and Outpatient Clinic of Occupational, Social and Enironmental Medicine, University of Erlangen Nuremberg, Germany
Int J Hyg Environ Health 210:35-42. 2007..Younger children seem to be more severely burdened, which may be due to a higher food consumption related to their bw, mouthing behaviour and/or playing near the ground...
- Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalateBethany R Hannas
Toxicology Assessment Division, Reproductive Toxicology Branch, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 123:206-16. 2011....
- High urinary phthalate concentration associated with delayed pubarche in girlsH Frederiksen
Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Int J Androl 35:216-26. 2012..We demonstrated that delayed pubarche, but not thelarche, was associated with high phthalate excretion in urine samples from 725 healthy school girls, which may suggest anti-androgenic actions of phthalates in our study group of girls...
- Association between pregnancy loss and urinary phthalate levels around the time of conceptionGunnar Toft
Danish Ramazzini Center, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
Environ Health Perspect 120:458-63. 2012..Animal studies indicate that some phthalate metabolites may harm female reproductive function...
- Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohortStephanie M Engel
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, United States
Neurotoxicology 30:522-8. 2009..This is the first study to report an association between prenatal phthalate exposure and neurological effects in humans or animals, and as such requires replication...
- Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and childrenLidia Casas
Centre for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain
Environ Int 37:858-66. 2011..Phthalate and phenol exposure is prevalent among the general population and of potential concern for pregnant women and children because of their suspected susceptibility to endocrine effects...
- Exposure to phthalates and phenols during pregnancy and offspring size at birthClaire Philippat
Institut National de la Sante et de la Recherche Medicale, Institut Albert Bonniot U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France
Environ Health Perspect 120:464-70. 2012..Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight...
- Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational studyJames L Preau
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 118:1748-54. 2010..Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months...
- Reproducibility of urinary phthalate metabolites in first morning urine samplesJane A Hoppin
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233, USA
Environ Health Perspect 110:515-8. 2002..5 for mBzP. These results suggest that even with the short half-lives of phthalates, women's patterns of exposure may be sufficiently stable to assign an exposure level based on a single first morning void urine measurement...
- PPAR-mediated activity of phthalates: A link to the obesity epidemic?Beatrice Desvergne
Centre Intégratif de Génomique, Universite de Lausanne, Switzerland
Mol Cell Endocrinol 304:43-8. 2009..A thorough analysis of its interactions with PPARgamma identified MEHP as a selective PPARgamma modulator, and thus a possible contributor to the obesity epidemic...
- Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: estimation of daily phthalate intakeHanne Frederiksen
Department of Growth and Reproduction, Section 5064, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Environ Res 111:656-63. 2011..They are suspected to be involved in male reproductive health problems and have also been associated with several other health problems in children including obesity and asthma...
- Personal care product use and urinary levels of phthalate metabolites in Mexican womenMichelle Romero-Franco
Center of Population Health Research, National Institute of Public Health, Mexico, Avenida Universidad No 655, Col Santa Maria Ahuacatitlan, Cerrada los Pinos y Caminera, CP 62100, Cuernavaca, Morelos, Mexico
Environ Int 37:867-71. 2011..Our results suggest that the use of some personal care products contributes to phthalate body burden that deserves attention due to its potential health impact...
- A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive mannerKembra L Howdeshell
Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 105:153-65. 2008..These data demonstrate that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture...
- Reproductive and developmental toxicity of phthalatesJan L Lyche
Department of Production Animal Clinical Science, Norwegian School of Veterinary Science, Oslo, Norway
J Toxicol Environ Health B Crit Rev 12:225-49. 2009..Thus, it is concluded that it is important to improve the knowledge of toxic interactions among the different chemicals and to develop measures for combined exposure to various groups of phthalates...
- Fetal exposure to phthalates--a pilot studyMatthias Wittassek
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstr 25 29, 91054 Erlangen, Germany
Int J Hyg Environ Health 212:492-8. 2009..Due to the continuous turn over of AF, urinary levels may be most appropriate for assessing both maternal and fetal phthalate exposure...
- The effects of work-related maternal risk factors on time to pregnancy, preterm birth and birth weight: the Generation R StudyA Burdorf
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
Occup Environ Med 68:197-204. 2011..To investigate the influence of maternal working conditions on fertility and pregnancy outcomes...
- Intake of phthalates and di(2-ethylhexyl)adipate: results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring dataHermann Fromme
Department of Environmental Health, Bavarian Health and Food Safety Authority, Veterinärstrasse 2, D 85764 Oberschleissheim, Germany
Environ Int 33:1012-20. 2007..Our data indicated that food was the predominant intake source of DEHP, whilst other sources considerably contributed to the daily intake of DnBP and DiBP in an adult population...
- Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanismAbdelali Lehraiki
Laboratory of Gonad Differentiation and Radiobiology, Stem Cells and Radiation Service, Institute of Cellular and Molecular Radiation Biology, Life Sciences Division, Commissariat a l Energie Atomique, BP 6, 92265 Fontenay aux Roses, France
Toxicol Sci 111:372-82. 2009....
- Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activationRobert M Sargis
Department of Medicine, Institute of Endocrine Discovery and Clinical Care, The University of Chicago, Chicago, Illinois, USA
Obesity (Silver Spring) 18:1283-8. 2010..Thus, EDCs are able to promote adipogenesis through the activation of the GR, further implicating these compounds in the rising rates of obesity and diabetes...
- Trends of the internal phthalate exposure of young adults in Germany--follow-up of a retrospective human biomonitoring studyThomas Göen
Institute und Outpatient Clinic of Occupational, Social und Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
Int J Hyg Environ Health 215:36-45. 2011..Future investigations should verify these trends. This is of increasing importance since the European Commission decided to require ban or authorization from 1.1.2015 for DEHP, DnBP, DiBP and BzBP according to REACh Annex XIV...
- Children's urinary phthalate metabolites and fractional exhaled nitric oxide in an urban cohortAllan C Just
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY 10032, USA
Am J Respir Crit Care Med 186:830-7. 2012..Associations between children's phthalate exposures and fractional exhaled nitric oxide (Fe(NO)), a biomarker of airway inflammation, have not been examined...
- Urinary biomarkers for phthalates associated with asthma in Norwegian childrenRandi J Bertelsen
Department of Food, Water and Cosmetics, Norwegian Institute of Public Health, Oslo, Norway
Environ Health Perspect 121:251-6. 2013..High-molecular-weight phthalates in indoor dust have been associated with asthma in children, but few studies have evaluated phthalate biomarkers in association with respiratory outcomes...
- Dietary intake is associated with phthalate body burden in a nationally representative sampleJustin A Colacino
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, USA
Environ Health Perspect 118:998-1003. 2010..Phthalates are compounds that are used in a wide range of consumer products. However, the contribution of dietary intake to phthalate exposure has not been well defined...
- Phthalates and other additives in plastics: human exposure and associated health outcomesJohn D Meeker
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Philos Trans R Soc Lond B Biol Sci 364:2097-113. 2009..Recent advances in the measurement of exposure biomarkers hold much promise in improving the epidemiological data, but their utility must be understood to facilitate appropriate study design...
- DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolitesR Hauser
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Hum Reprod 22:688-95. 2007....
- Occurrence of phthalates and musk fragrances in indoor air and dust from apartments and kindergartens in Berlin (Germany)H Fromme
Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Veterinärstrasse, Oberschleissheim, Germany
Indoor Air 14:188-95. 2004....
- In utero exposure to butyl benzyl phthalate induces modifications in the morphology and the gene expression profile of the mammary gland: an experimental study in ratsRaquel Moral
Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Environ Health 10:5. 2011..The aim of this study was to elucidate the effect of prenatal exposure to BBP on the morphology, proliferative index, and genomic signature of the rat mammary gland at different ages...
- Comparative assessment of human exposure to phthalate esters from house dust in China and the United StatesYing Guo
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, United States
Environ Sci Technol 45:3788-94. 2011..This is the first study to elucidate sources of human exposure to phthalates among the general population in China...
- Occurrence of phthalate esters in water and sediment of urban lakes in a subtropical city, Guangzhou, South ChinaFeng Zeng
School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangdong, Guangzhou 51027, China
Environ Int 34:372-80. 2008..01), and that DiBP was a predictive indicator for the sediment summation operator16 PAEs concentration (r=0.975, p<0.01). As compared to the results for other studies, the urban lakes of Guangzhou were moderately polluted by PAEs...
- Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometryHanne Frederiksen
Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
J Anal Toxicol 34:400-10. 2010..In seminal plasma, only MEP levels correlated significantly to levels in urine and in serum...
- The internal exposure of Taiwanese to phthalate--an evidence of intensive use of plastic materialsMei Lien Chen
Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang Ming University, Taipei, Taiwan
Environ Int 34:79-85. 2008..We conclude that the body burden of DEHP for Taiwanese reflects the intensives use of plastic materials in the region. The regulation of PVC for food preparation is necessary...
- The association between phthalates in dust and allergic diseases among Bulgarian childrenBarbara Kolarik
Technical University of Denmark, Department of Mechanical Engineering, International Centre for Indoor Environment and Energy, Lyngby, Denmark
Environ Health Perspect 116:98-103. 2008..Recent studies have identified associations between the concentration of phthalates in indoor dust and allergic symptoms in the airways, nose, and skin...
- Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growthMalene Boas
Department of Growth and Reproduction, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
Environ Health Perspect 118:1458-64. 2010..Phthalates are widely used chemicals, and human exposure is extensive. Recent studies have indicated that phthalates may have thyroid-disrupting properties...
- Distribution of phthalate esters in alluvial sediment: a case study at JiangHan Plain, Central ChinaHui Liu
Key Laboratory of Biogeology and Environmental Geology of Ministry of Education and School of Environmental Studies, China University of Geosciences, Wuhan 430074, China
Chemosphere 78:382-8. 2010..On the other hand, DEHP, DnBP, and DiBP could be transported into deep sediment along with the horizontal flow of shallow groundwater from surface water, such as Yangtze River, Hanjiang River, and Honghu Lake...
- Prenatal exposure to phthalates and infant development at 6 months: prospective Mothers and Children's Environmental Health (MOCEH) studyYeni Kim
Department of Adolescent Psychiatry, National Center for Child and Adolescent Psychiatry, Seoul National Hospital, Seoul, Korea
Environ Health Perspect 119:1495-500. 2011..There are increasing concerns over adverse effects of prenatal phthalate exposure on the neurodevelopment of infants...
- Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderlyP Monica Lind
Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
Atherosclerosis 218:207-13. 2011..Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study...
- PVC--as flooring material--and its association with incident asthma in a Swedish child cohort studyM Larsson
Karlstad University, Health and Environmental Sciences, Karlstad, Sweden
Indoor Air 20:494-501. 2010..PVC-flooring was found to be a stronger risk factor for incident asthma in multifamily homes when compared with single-family houses and in smoking families compared with non-smoking families and in women...
- Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproductionMariko Matsumoto
Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Regul Toxicol Pharmacol 50:37-49. 2008..However, because it is difficult to find alternative methods to examine the direct toxic effects of chemicals, animal studies remain necessary for risk assessment of chemicals including PAEs...
- Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed ratsJulie Boberg
Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
Reprod Toxicol 31:200-9. 2011..These results show that DINP causes anti-androgenic effects on reproductive development, though less potent than DEHP, DBP and BBP, and further safety evaluation of DINP appears warranted...
- Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive developmentCynthia V Rider
MD 72, Endocrinology Branch, Reproductive Toxicology Division, NHEERL, ORD, U S Environmental Protection Agency, RTP, North Carolina 27713, USA
Toxicol Pathol 37:100-13. 2009..In this study, the complex mixture behaved in a dose-additive manner. Our results indicate that compounds that act by disparate mechanisms of toxicity display cumulative, dose-additive effects when present in combination...
- Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalatesBethany R Hannas
National Research Council Fellowship Program, National Health and Environmental Effects Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 120:184-93. 2011....
- Foetal exposure to phthalate esters and anogenital distance in male newbornsY Suzuki
Department of Environmental Studies, The University of Tokyo, Chiba, Japan
Int J Androl 35:236-44. 2012..Urinary isoflavones did not significantly contribute to AGI in any models. Our results suggest that prenatal exposure to di(2-ethylhexyl) phthalate affects reproductive development in human males...
- Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancyJoe M Braun
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 120:739-45. 2012..Gestational phthalate and bisphenol A (BPA) exposure may increase the risk of adverse maternal/child health outcomes, but there are few data on the variability of urinary biomarkers before and during pregnancy...
- Exposure to phthalates in 5-6 years old primary school starters in Germany--a human biomonitoring study and a cumulative risk assessmentHolger M Koch
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
Int J Hyg Environ Health 214:188-95. 2011..Therefore, the overall exposure to a number of phthalates, and the knowledge that these phthalates (and other anti-androgens) act in a dose-additive manner, urgently warrants a cumulative risk assessment approach...
- The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: a systematic review and meta-analysisJouni J K Jaakkola
Institute of Occupational and Environmental Medicine, University of Birmingham, Birmingham, United Kingdom
Environ Health Perspect 116:845-53. 2008..Phthalates from polyvinyl chloride (PVC) plastics may have adverse effects on airways and immunologic systems, but the evidence has not been reviewed systematically...
- A biomarker approach to measuring human dietary exposure to certain phthalate diestersW A Anderson
Ministry of Agriculture Fisheries and Food, Central Science Laboratory, Sand Hutton, York, UK
Food Addit Contam 18:1068-74. 2001..These conversion factors can be used in future studies to assess exposure to phthalate esters via measuring urinary levels of the monoester metabolites...
- Within-person variability in urinary phthalate metabolite concentrations: measurements from specimens after long-term frozen storageDonna Day Baird
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Expo Sci Environ Epidemiol 20:169-75. 2010..These findings support the use of stored urine specimens collected during the relevant stage of human pregnancy to investigate the influence of phthalate exposures on later outcomes...
- Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa)Xibiao Ye
Epidemiology Branch, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, MD A3 05, PO Box 12233, Research Triangle Park, NC 27709, USA
Int J Hyg Environ Health 212:481-91. 2009....
- Relationship between environmental phthalate exposure and the intelligence of school-age childrenSoo Churl Cho
Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Republic of Korea
Environ Health Perspect 118:1027-32. 2010..Concern over phthalates has emerged because of their potential toxicity to humans...
- Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory ratsKembra L Howdeshell
Reproductive Toxicology Division, National Health and Environmental Effects Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Environ Res 108:168-76. 2008..Since phthalate ester metabolites are detected in maternal and fetal body fluids, and androgen-signaling and insl3 are highly conserved among mammals, phthalates may potentially affect human reproductive development...
- Association between prenatal exposure to phthalates and the health of newbornsPo Chin Huang
Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, Tainan, Taiwan
Environ Int 35:14-20. 2009....
- Exposure to phthalates and breast cancer risk in northern MexicoLizbeth Lopez-Carrillo
National Institute of Public Health, Cuernavaca, Morelos, Mexico
Environ Health Perspect 118:539-44. 2010..Phthalates, ubiquitous environmental pollutants that may disturb the endocrine system, are used primarily as plasticizers of polyvinyl chloride and as additives in consumer and personal care products...
- Medications as a source of human exposure to phthalatesRuss Hauser
Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Environ Health Perspect 112:751-3. 2004..Further research is necessary to determine the proportional contribution of medications, as well as personal care and consumer products, to a person's total phthalate burden...
- Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkersDana B Barr
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 111:1148-51. 2003....
- Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case studyAntonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 114:1783-9. 2006..Although the vast and growing literature on phthalates research could not be covered comprehensively in this article, we made every attempt to include the most relevant publications as of the end of 2005...
- Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanismChristopher J Thompson
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
Endocrinology 145:1227-37. 2004....
- Assessment of human exposure to di-isodecyl phthalate using oxidative metabolites as biomarkersM J Silva
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Biomarkers 12:133-44. 2007..These data also suggest that unless oxidative metabolites are measured, the prevalence of exposure to DiDP will probably be underestimated...
- [Study on the level of phthalates in human biological samples]Yun Hui Zhang
Department of Environmental Health Sciences, School of Public Health, Fudan University, Shanghai 200032, China
Zhonghua Yu Fang Yi Xue Za Zhi 37:429-34. 2003..To monitor the level of phthalates in human biological samples...
- Quantitative identification of unknown exposure pathways of phthalates based on measuring their metabolites in human urineHiroaki Itoh
Graduate School of Environment and Information Sciences, Yokohama National University, Tokiwadai 79 7, Hodogaya ku, Yokohama 240 8501, Japan
Environ Sci Technol 41:4542-7. 2007..The probabilities that the log normal distribution of each phthalate daily intake estimated from the present study exceeds the corresponding tolerable daily intake were estimated to be less than 10(-4)...
- Urinary metabolites of diisodecyl phthalate in ratsKayoko Kato
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Toxicology 236:114-22. 2007..Additional research on the toxicokinetics of these metabolites is needed to understand the extent of human exposure to DiDP from the urinary concentrations of MCiNP and other DiDP secondary metabolites...
- Two-generation reproduction studies in Rats fed di-isodecyl phthalateL J Hushka
ExxonMobil Biomedical Sciences, Inc, Annandale NJ, USA
Reprod Toxicol 15:153-69. 2001..Statistical evaluation of the data from both studies identified 108 mg/kg/day with a 95% lower bound value of 86 mg/kg/day as a theoretical NOAEL for reduced F2 offspring survival...
- The relationship between environmental exposure to phthalates and computer-aided sperm analysis motion parametersSusan M Duty
Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Androl 25:293-302. 2004..Although we did not find statistically significant associations, trends between CASA parameters, sperm velocity, and forward progression, and increased urinary levels of MBP, MBzP, and MEHP warrant further follow-up...
- Maternal Phthalate Exposure and Infertility, Fetal LossRuss Hauser; Fiscal Year: 2007..Since occupational and environmental exposure to phthalates is widespread, detecting even small adverse effects will have large public health significance. ..
- Maternal Pesticide Exposure and Pregnancy OutcomesRuss Hauser; Fiscal Year: 2009..Since the etiology of infertility and early pregnancy loss remains largely unexplained, the identification of potential environmental risk factors will have large public health significance. ..
- US STUDY OF SEMEN QUALITY IN PARTNERS OF PREGNANT WOMENShanna Swan; Fiscal Year: 2001....
- Environmental Endocrine Disrupters 2008 Gordon Research ConferenceShanna Swan; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESESArun Ghosh; Fiscal Year: 2001..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
- Neurotoxic Interactions of Different Forms of MercuryBernard Weiss; Fiscal Year: 2007..The acquisition of these data offers a firm foundation for determining the risks to neurobehavioral development of concurrent exposures to both mercury species. ..
- Molecular Epidemiology of Xenoestrogen ExposureSusan Teitelbaum; Fiscal Year: 2008..Furthermore, data analysis approaches applied in this research project will be applicable to a wide range of environmentally associated diseases. ..
- Developmental Neurotoxicity of Phthalate EstersBernard Weiss; Fiscal Year: 2008..The proposed research will examine this question in rats, and translate its implications into human relevance. [unreadable] [unreadable] [unreadable]..
- SERTOLI CELL TOXICITY IN VIVO--MICROTUBULE DISRUPTIONKim Boekelheide; Fiscal Year: 2001..Together, these complimentary approaches will critically examine key steps in the pathogenetic sequence by which microtubule disrupters alter the supportive capacity of Sertoli cells resulting in loss of germ cells and infertility. ..
- DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORSArun K Ghosh; Fiscal Year: 2010..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
- ENVIRONMENTAL/INDUSTRIAL TOXICANTS AND TESTICULAR INJURYKim Boekelheide; Fiscal Year: 2003..Together, these complimentary approaches will elucidate the key molecular mechanisms responsible for irreversible testicular injury. ..
- Advanced Reproductive Age and Environmental HealthStephanie Engel; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53Kim Boekelheide; Fiscal Year: 2007..unreadable] [unreadable]..
- A Pilot Study Of Internet Recruitment and follow-up among Reproductive Age WomenELIZABETH HATCH; Fiscal Year: 2007..If successful, we envision this study to be the first of more elaborate studies that employ the internet to enroll cohort members into long-term follow-up studies. [unreadable] [unreadable] [unreadable]..
- The Association between obesity, central adiposity and endocrine disruptorsELIZABETH HATCH; Fiscal Year: 2007..Nevertheless, it may provide important clues for future, epidemiologic studies of the effect of these environmental contaminants on the risk of obesity. [unreadable] [unreadable] [unreadable]..
- Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early ChildhoodKimberly Yolton; Fiscal Year: 2010....
- Molecular Mechanisms of Phthalate-induced CarcinogenesisIvan Rusyn; Fiscal Year: 2007..This results in a "potentiation" of a non-specific mitogen release from Kupffer cells activated by lipid-like peroxisome proliferator particles, thus accounting for a characteristic burst of proliferation in the liver. ..
- Ovary Intact Murine Model for MenopausePatricia Hoyer; Fiscal Year: 2007..Characterization of the VCD-treated mouse will, therefore, make a profound contribution to the study of menopause-related pathologies and, therefore, to women's health. ..
- Metabolomic and Toxicogenetic Study of Ethanol ToxicityIvan Rusyn; Fiscal Year: 2009..abstract_text> ..
- Estrogen Receptor-related Receptor Action in ZebrafishAnn Tarrant; Fiscal Year: 2007..unreadable] [unreadable]..
- ENVIRONMENTAL EPOXIDES--MECHANISMS OF OVOTOXICITYPatricia Hoyer; Fiscal Year: 2002..The results of these studies will provide greater insight as to the impact of exposure to ovotoxic environmental chemicals on reproductive health in women. ..
- Validation of biomarkers of prenatal pesticides exposureRobin Whyatt; Fiscal Year: 2003....
- CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASEAlicia Rivera; Fiscal Year: 2003..It is additionally significant, because it will provide the means for the applicant to establish an independent research career and to become competitive for a tenure-track assistant professional position. ..
- LC-MS/MS Methods for Analysis of Hemoglogbin AdductsTimothy Fennell; Fiscal Year: 2004..abstract_text> ..
- DNA REPAIR AND SUSCEPTIBILITY TO ENVIRONMENTAL AGENTSIvan Rusyn; Fiscal Year: 2004..These experiments will also provide crucial mechanistic insights into possible differences in species- and tissue-specific responses to DNA damage induced by environmental agents. ..
- Exploration of ETS Effects on Child Behavior and SleepKimberly Yolton; Fiscal Year: 2005..abstract_text> ..
- Bridge to the Doctorate at UMET: Building the Next Gene*Beatriz Zayas; Fiscal Year: 2005..Thus, for the duration of the project a grand total of 540 students will benefit from these development activities and will learn more about graduate studies in biomedical sciences. ..
- Prenatal Insecticide Exposures Among Urban MinoritiesRobin Whyatt; Fiscal Year: 2005..The research will provide important information about pesticide exposure during pregnancy among this minority cohort. ..
- Cytokines in Sickle Cell Volume RegulationAlicia Rivera; Fiscal Year: 2006..abstract_text> ..
- SIGNALING PATHWAYS IN CHEMICAL INDUCED OVOTOXICITYPatricia B Hoyer; Fiscal Year: 2010..This will lead to an appreciation of the global impact of the environment on the reproductive life span in women. ..
- The Role of Egr-1 in GnRH NeuronsSara DiVall; Fiscal Year: 2005..Protein-DNA binding studies will be performed on candidate regions of the GnRH promoter. This could define a link between nutritional status and reproductive competency at a molecular level. ..
- Cholinergic modulation of IEG expressionANN POWER; Fiscal Year: 2006..Experiment III will investigate which signaling cascades (e.g., protein kinases) are involved in effects of mR activation on memory and immediate early gene expression. ..
- Isolation and Characterization of Testis Stem CellsMarie Claude Hofmann; Fiscal Year: 2009..In particular, the role of the growth factor GDNF in regulating self-renewal and/or differentiation will be elucidated. ..
- Novel Approaches to Studying the Situ Bioremediation of Complex MixturesROLF HALDEN; Fiscal Year: 2009..abstract_text> ..
- Wearable Organic Electric Film RFID Sensors for Monitoring of Airborne ToxicantsRadislav A Potyrailo; Fiscal Year: 2010..This new sensing approach will provide a wearable, cost-effective, selective sensor for de- tection of toxic volatile species. ..
- Metabolomics: Markers of Drug-Induced Liver Injury(RMI)Susan Sumner; Fiscal Year: 2008..The signals defining these patterns will be identified using GC-MS, NMR, and LC-MS/MS methods and then assigned to biochemical pathways for defining the relevancy of the marker profiles to mode of action. ..
- Assessment of Infant Outcomes After in Utero Exposure to Antiretroviral TherapySonia Hernandez diaz; Fiscal Year: 2010..We propose to evaluate the risk of congenital malformations and other adverse pregnancy outcomes following antenatal exposure to ART in a prospective cohort of pregnant women. ..
- REGULATION OF THE STEROIDOGENIC ACUTE REGULATORY PROTEINBarbara Clark; Fiscal Year: 2005..This will ultimately lead to a better understanding of potential developmental or disease states that result from aberrant over- or under-expression of StAR in a cell-specific manner. ..
- Indoor Environment and Symptoms in Office BuildingMARK MENDELL; Fiscal Year: 2006..abstract_text> ..