phthalic acids

Summary

Summary: A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)

Top Publications

  1. pmc Temporal variability of urinary phthalate metabolite levels in men of reproductive age
    Russ Hauser
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 112:1734-40. 2004
  2. pmc Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Environ Health Perspect 112:331-8. 2004
  3. pmc Prenatal phenol and phthalate exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 116:1092-7. 2008
  4. ncbi Prenatal exposure to phthalate esters and PAHs and birth outcomes
    Yayoi Suzuki
    Department of Environmental Studies, University of Tokyo, Chiba, Japan
    Environ Int 36:699-704. 2010
  5. pmc Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002
    Elizabeth E Hatch
    Department of Epidemiology, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA
    Environ Health 7:27. 2008
  6. pmc Associations between phthalate metabolite urinary concentrations and body size measures in New York City children
    Susan L Teitelbaum
    Mount Sinai School of Medicine, Department of Preventive Medicine, One Gustave L Levy Place, Box 1057, NY 10029, USA
    Environ Res 112:186-93. 2012
  7. ncbi What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?
    Matthias Wormuth
    Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland
    Risk Anal 26:803-24. 2006
  8. pmc Prenatal phthalate exposure is associated with childhood behavior and executive functioning
    Stephanie M Engel
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 118:565-71. 2010
  9. pmc Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males
    Richard W Stahlhut
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 115:876-82. 2007
  10. ncbi Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States
    S L Teitelbaum
    Mount Sinai School of Medicine, Department of Community and Preventive Medicine, 1 Gustave Levy Place, P O Box 1043, New York, NY 10029, USA
    Environ Res 106:257-69. 2008

Detail Information

Publications262 found, 100 shown here

  1. pmc Temporal variability of urinary phthalate metabolite levels in men of reproductive age
    Russ Hauser
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 112:1734-40. 2004
    ..In particular, a single urine sample was most predictive for MEP and least predictive for MEHP. These results suggest that the most efficient exposure assessment strategy for a particular study may depend on the phthalates of interest...
  2. pmc Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Environ Health Perspect 112:331-8. 2004
    ....
  3. pmc Prenatal phenol and phthalate exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 116:1092-7. 2008
    ..Many phthalates and phenols are hormonally active and are suspected to alter the course of development...
  4. ncbi Prenatal exposure to phthalate esters and PAHs and birth outcomes
    Yayoi Suzuki
    Department of Environmental Studies, University of Tokyo, Chiba, Japan
    Environ Int 36:699-704. 2010
    ..In conclusion, we found that prenatal exposure to phthalate esters or PAHs did not affect birth outcomes at the exposure level of the present subjects...
  5. pmc Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002
    Elizabeth E Hatch
    Department of Epidemiology, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA
    Environ Health 7:27. 2008
    ..Although diet and activity are key factors in the obesity epidemic, laboratory studies suggest that endocrine disrupting chemicals may also affect obesity...
  6. pmc Associations between phthalate metabolite urinary concentrations and body size measures in New York City children
    Susan L Teitelbaum
    Mount Sinai School of Medicine, Department of Preventive Medicine, One Gustave L Levy Place, Box 1057, NY 10029, USA
    Environ Res 112:186-93. 2012
    ..To examine prospectively associations between urinary phthalate metabolite concentrations and body size measures in children...
  7. ncbi What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?
    Matthias Wormuth
    Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland
    Risk Anal 26:803-24. 2006
    ..The scenario-based approach chosen in the present study provides a link between the knowledge on emission sources of phthalates and the concentrations of phthalate metabolites found in human urine...
  8. pmc Prenatal phthalate exposure is associated with childhood behavior and executive functioning
    Stephanie M Engel
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 118:565-71. 2010
    ..Experimental and observational studies have reported biological consequences of phthalate exposure relevant to neurodevelopment...
  9. pmc Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males
    Richard W Stahlhut
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 115:876-82. 2007
    ..Low testosterone in adult human males has been associated with increased prevalence of obesity, insulin resistance, and diabetes...
  10. ncbi Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States
    S L Teitelbaum
    Mount Sinai School of Medicine, Department of Community and Preventive Medicine, 1 Gustave Levy Place, P O Box 1043, New York, NY 10029, USA
    Environ Res 106:257-69. 2008
    ..However, reliability in the use of these biomarkers requires an understanding of the timeframe of exposure represented by one measurement. Data on the temporal variability of ED biomarkers are sparse, especially among children...
  11. pmc Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age
    Robin M Whyatt
    Department of Environmental Health Sciences, Columbia Center for Children s Environmental Health Department of Environmental Health Sciences, Mailman School of Public Health, 722 West 168th St, New York, NY 10032 USA
    Environ Health Perspect 120:290-5. 2012
    ..Research suggests that prenatal phthalate exposures affect child executive function and behavior...
  12. pmc Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 119:1396-402. 2011
    ..Limited animal, in vitro, and human studies have reported that exposure to phthalates or bisphenol A (BPA) may affect thyroid signaling...
  13. pmc Phthalate exposure and pulmonary function
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, PO Box 12233, Research Triangle Park, NC 27709 2233, USA
    Environ Health Perspect 112:571-4. 2004
    ..Our results suggest that MBP and MEP, but not MEHP, may influence pulmonary function among adult males...
  14. ncbi Phthalate exposure in pregnant women and their children in central Taiwan
    Susana Lin
    National Health Research Institutes, Taiwan
    Chemosphere 82:947-55. 2011
    ..The level of phthalate metabolites in milk and cord blood were comparable to those found in other populations. Further studies of health effects related to DEHP and DiNP exposure are necessary for the children...
  15. ncbi Reproductive toxicity of phthalate esters
    Anderson Joel Martino-Andrade
    Universidade Federal do Parana, Departamento de Fisiologia, Curitiba, Brazil
    Mol Nutr Food Res 54:148-57. 2010
    ..Finally, we point out some critical issues that should be addressed in order to clarify the implications of phthalates for human reproduction...
  16. ncbi Phthalate exposure associated with self-reported diabetes among Mexican women
    Katherine Svensson
    Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, USA
    Environ Res 111:792-6. 2011
    ..This exploratory cross-sectional study evaluated the possible association between phthalate exposure and self-reported diabetes among adult Mexican women...
  17. ncbi Phthalates: toxicology and exposure
    Ursel Heudorf
    Public Health Department of the City of Frankfurt, Germany
    Int J Hyg Environ Health 210:623-34. 2007
    ..However, health concern is raised regarding the developmental and/or reproductive toxicity of phthalates, even in environmental concentrations...
  18. ncbi Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure
    Diane Koniecki
    Cosmetics Division, Health Canada, Ottawa, Canada
    Environ Res 111:329-36. 2011
    ..03 μg/kg bw/d). The exposure for DiBP was not calculated due to its very low levels (<10 μg/g) in products. Toddlers and infants in this case had a maximal daily exposure to DEP of 20 and 42 μg/kg bw/d, respectively...
  19. pmc Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans
    Shanna H Swan
    Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 668, Rochester, NY 14642, USA
    Environ Res 108:177-84. 2008
    ..Replication of the results described here and further mechanistic studies are needed to strengthen links between phthalates and adverse health outcomes...
  20. pmc Variability and predictors of urinary bisphenol A concentrations during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard University, Boston, Massachusetts, USA
    Environ Health Perspect 119:131-7. 2011
    ..Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy...
  21. pmc Association of endocrine disruptors and obesity: perspectives from epidemiological studies
    E E Hatch
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Int J Androl 33:324-32. 2010
    ..As this field of research advances, there are challenging methodological questions that must be considered by both epidemiologists and toxicologists...
  22. pmc Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls
    Mary S Wolff
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Environ Health Perspect 118:1039-46. 2010
    ..Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by steroids and gonadotropins...
  23. pmc Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention
    Ruthann A Rudel
    Silent Spring Institute, Newton, Massachusetts 02458, USA
    Environ Health Perspect 119:914-20. 2011
    ..They have been associated with endocrine disruption in animals and in some human studies. Human exposure sources have been estimated, but the relative contribution of dietary exposure to total intake has not been studied empirically...
  24. pmc Consumer product exposures associated with urinary phthalate levels in pregnant women
    Jessie P Buckley
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    J Expo Sci Environ Epidemiol 22:468-75. 2012
    ..Although personal care product use may be an important predictor of urinary phthalate levels, most of the variability in phthalate exposure was not captured by our relatively comprehensive set of questionnaire items...
  25. pmc Urinary phthalate metabolite concentrations and diabetes among women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008
    Tamarra James-Todd
    Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont St, Division of Women s Health, 3rd Floor, Boston, MA 02120, USA
    Environ Health Perspect 120:1307-13. 2012
    ..Few studies have evaluated the association between phthalate metabolites, diabetes, and diabetes-related risk factors among women...
  26. pmc Prenatal exposure to butylbenzyl phthalate and early eczema in an urban cohort
    Allan C Just
    Columbia Center for Children s Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 120:1475-80. 2012
    ..Recent cross-sectional studies suggest a link between butylbenzyl phthalate (BBzP) in house dust and childhood eczema...
  27. pmc Human body burdens of chemicals used in plastic manufacture
    Holger M Koch
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Bochum, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2063-78. 2009
    ..We discuss several factors relevant for interpreting and understanding biomonitoring data, including selection of both biomarkers of exposure and human matrices, and toxicokinetic information...
  28. ncbi Phthalate exposure and asthma in children
    C G Bornehag
    Public Health Sciences, Karlstad University, Karlstad, Sweden
    Int J Androl 33:333-45. 2010
    ..But the important questions of clinical relevance of real life exposure and identification of molecular targets that can explain interactions largely remain to be answered...
  29. pmc Prenatal phthalate exposure and reduced masculine play in boys
    S H Swan
    Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA
    Int J Androl 33:259-69. 2010
    ..Our findings suggest that these ubiquitous environmental chemicals have the potential to alter androgen-responsive brain development in humans...
  30. ncbi PVC flooring is related to human uptake of phthalates in infants
    F Carlstedt
    Primary Care Research Unit, County Council of Varmland, Karlstad, Sweden
    Indoor Air 23:32-9. 2013
    ..Urinary levels of phthalate metabolites during early life are associated with the use of PVC flooring in the bedroom, body area, and the use of infant formula...
  31. ncbi Phthalate levels and low birth weight: a nested case-control study of Chinese newborns
    Yunhui Zhang
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
    J Pediatr 155:500-4. 2009
    ..To assess maternal-fetal exposure to phthalates and investigate whether in utero phthalate exposure is associated with low birth weight (LBW)...
  32. ncbi Exposure to phthalates: reproductive outcome and children health. A review of epidemiological studies
    Joanna Jurewicz
    Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland
    Int J Occup Med Environ Health 24:115-41. 2011
    ..Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented...
  33. ncbi Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans
    Nadeem Rezaq Janjua
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 31:118-30. 2008
    ..The three chemicals are systemically absorbed, metabolized and excreted in urine following application on the skin in a cream preparation. More DEP than DBP was absorbed, presumably because of a faster absorption rate for DEP...
  34. ncbi Internal phthalate exposure over the last two decades--a retrospective human biomonitoring study
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 210:319-33. 2007
    ....
  35. ncbi Human exposure to phthalates via consumer products
    Ted Schettler
    Science and Environmental Health Network, Newburyport, MA, USA
    Int J Androl 29:134-9; discussion 181-5. 2006
    ..Oven baking of polymer clays may cause short-term, high-level inhalation exposures to higher molecular weight phthalates...
  36. ncbi Phthalates: metabolism and exposure
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Androl 31:131-8. 2008
    ..Therefore, the concept of a cumulative TDI value may be more appropriate for the consideration of the overall exposure and the potential human health risks resulting from everyday and simultaneous exposure to several phthalates...
  37. ncbi An assessment of the ability of phthalates to influence immune and allergic responses
    Ian Kimber
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Toxicology 271:73-82. 2010
    ....
  38. ncbi Phthalate metabolites in urine from China, and implications for human exposures
    Ying Guo
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    Environ Int 37:893-8. 2011
    ..S. Environmental Protection Agency...
  39. ncbi Associations between maternal phthalate exposure and cord sex hormones in human infants
    Lung Cheng Lin
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
    Chemosphere 83:1192-9. 2011
    ..We suggest that maternal exposure to phthalates may affect sex steroid hormones status in fetal and newborn stage...
  40. ncbi Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children -- A comparison of two estimation models based on urinary DEHP metabolite levels
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Enironmental Medicine, University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 210:35-42. 2007
    ..Younger children seem to be more severely burdened, which may be due to a higher food consumption related to their bw, mouthing behaviour and/or playing near the ground...
  41. ncbi Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate
    Bethany R Hannas
    Toxicology Assessment Division, Reproductive Toxicology Branch, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:206-16. 2011
    ....
  42. ncbi High urinary phthalate concentration associated with delayed pubarche in girls
    H Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Androl 35:216-26. 2012
    ..We demonstrated that delayed pubarche, but not thelarche, was associated with high phthalate excretion in urine samples from 725 healthy school girls, which may suggest anti-androgenic actions of phthalates in our study group of girls...
  43. pmc Association between pregnancy loss and urinary phthalate levels around the time of conception
    Gunnar Toft
    Danish Ramazzini Center, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Environ Health Perspect 120:458-63. 2012
    ..Animal studies indicate that some phthalate metabolites may harm female reproductive function...
  44. pmc Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohort
    Stephanie M Engel
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, United States
    Neurotoxicology 30:522-8. 2009
    ..This is the first study to report an association between prenatal phthalate exposure and neurological effects in humans or animals, and as such requires replication...
  45. ncbi Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children
    Lidia Casas
    Centre for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain
    Environ Int 37:858-66. 2011
    ..Phthalate and phenol exposure is prevalent among the general population and of potential concern for pregnant women and children because of their suspected susceptibility to endocrine effects...
  46. pmc Exposure to phthalates and phenols during pregnancy and offspring size at birth
    Claire Philippat
    Institut National de la Sante et de la Recherche Medicale, Institut Albert Bonniot U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France
    Environ Health Perspect 120:464-70. 2012
    ..Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight...
  47. pmc Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational study
    James L Preau
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 118:1748-54. 2010
    ..Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months...
  48. pmc Reproducibility of urinary phthalate metabolites in first morning urine samples
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233, USA
    Environ Health Perspect 110:515-8. 2002
    ..5 for mBzP. These results suggest that even with the short half-lives of phthalates, women's patterns of exposure may be sufficiently stable to assign an exposure level based on a single first morning void urine measurement...
  49. ncbi PPAR-mediated activity of phthalates: A link to the obesity epidemic?
    Beatrice Desvergne
    Centre Intégratif de Génomique, Universite de Lausanne, Switzerland
    Mol Cell Endocrinol 304:43-8. 2009
    ..A thorough analysis of its interactions with PPARgamma identified MEHP as a selective PPARgamma modulator, and thus a possible contributor to the obesity epidemic...
  50. ncbi Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: estimation of daily phthalate intake
    Hanne Frederiksen
    Department of Growth and Reproduction, Section 5064, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Environ Res 111:656-63. 2011
    ..They are suspected to be involved in male reproductive health problems and have also been associated with several other health problems in children including obesity and asthma...
  51. ncbi Personal care product use and urinary levels of phthalate metabolites in Mexican women
    Michelle Romero-Franco
    Center of Population Health Research, National Institute of Public Health, Mexico, Avenida Universidad No 655, Col Santa Maria Ahuacatitlan, Cerrada los Pinos y Caminera, CP 62100, Cuernavaca, Morelos, Mexico
    Environ Int 37:867-71. 2011
    ..Our results suggest that the use of some personal care products contributes to phthalate body burden that deserves attention due to its potential health impact...
  52. ncbi A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
    Kembra L Howdeshell
    Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 105:153-65. 2008
    ..These data demonstrate that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture...
  53. ncbi Reproductive and developmental toxicity of phthalates
    Jan L Lyche
    Department of Production Animal Clinical Science, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health B Crit Rev 12:225-49. 2009
    ..Thus, it is concluded that it is important to improve the knowledge of toxic interactions among the different chemicals and to develop measures for combined exposure to various groups of phthalates...
  54. ncbi Fetal exposure to phthalates--a pilot study
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstr 25 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 212:492-8. 2009
    ..Due to the continuous turn over of AF, urinary levels may be most appropriate for assessing both maternal and fetal phthalate exposure...
  55. ncbi The effects of work-related maternal risk factors on time to pregnancy, preterm birth and birth weight: the Generation R Study
    A Burdorf
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Occup Environ Med 68:197-204. 2011
    ..To investigate the influence of maternal working conditions on fertility and pregnancy outcomes...
  56. ncbi Intake of phthalates and di(2-ethylhexyl)adipate: results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data
    Hermann Fromme
    Department of Environmental Health, Bavarian Health and Food Safety Authority, Veterinärstrasse 2, D 85764 Oberschleissheim, Germany
    Environ Int 33:1012-20. 2007
    ..Our data indicated that food was the predominant intake source of DEHP, whilst other sources considerably contributed to the daily intake of DnBP and DiBP in an adult population...
  57. pmc Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanism
    Abdelali Lehraiki
    Laboratory of Gonad Differentiation and Radiobiology, Stem Cells and Radiation Service, Institute of Cellular and Molecular Radiation Biology, Life Sciences Division, Commissariat a l Energie Atomique, BP 6, 92265 Fontenay aux Roses, France
    Toxicol Sci 111:372-82. 2009
    ....
  58. pmc Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activation
    Robert M Sargis
    Department of Medicine, Institute of Endocrine Discovery and Clinical Care, The University of Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:1283-8. 2010
    ..Thus, EDCs are able to promote adipogenesis through the activation of the GR, further implicating these compounds in the rising rates of obesity and diabetes...
  59. ncbi Trends of the internal phthalate exposure of young adults in Germany--follow-up of a retrospective human biomonitoring study
    Thomas Göen
    Institute und Outpatient Clinic of Occupational, Social und Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Int J Hyg Environ Health 215:36-45. 2011
    ..Future investigations should verify these trends. This is of increasing importance since the European Commission decided to require ban or authorization from 1.1.2015 for DEHP, DnBP, DiBP and BzBP according to REACh Annex XIV...
  60. pmc Children's urinary phthalate metabolites and fractional exhaled nitric oxide in an urban cohort
    Allan C Just
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY 10032, USA
    Am J Respir Crit Care Med 186:830-7. 2012
    ..Associations between children's phthalate exposures and fractional exhaled nitric oxide (Fe(NO)), a biomarker of airway inflammation, have not been examined...
  61. pmc Urinary biomarkers for phthalates associated with asthma in Norwegian children
    Randi J Bertelsen
    Department of Food, Water and Cosmetics, Norwegian Institute of Public Health, Oslo, Norway
    Environ Health Perspect 121:251-6. 2013
    ..High-molecular-weight phthalates in indoor dust have been associated with asthma in children, but few studies have evaluated phthalate biomarkers in association with respiratory outcomes...
  62. pmc Dietary intake is associated with phthalate body burden in a nationally representative sample
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, USA
    Environ Health Perspect 118:998-1003. 2010
    ..Phthalates are compounds that are used in a wide range of consumer products. However, the contribution of dietary intake to phthalate exposure has not been well defined...
  63. pmc Phthalates and other additives in plastics: human exposure and associated health outcomes
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Philos Trans R Soc Lond B Biol Sci 364:2097-113. 2009
    ..Recent advances in the measurement of exposure biomarkers hold much promise in improving the epidemiological data, but their utility must be understood to facilitate appropriate study design...
  64. ncbi DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites
    R Hauser
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Reprod 22:688-95. 2007
    ....
  65. ncbi Occurrence of phthalates and musk fragrances in indoor air and dust from apartments and kindergartens in Berlin (Germany)
    H Fromme
    Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Veterinärstrasse, Oberschleissheim, Germany
    Indoor Air 14:188-95. 2004
    ....
  66. pmc In utero exposure to butyl benzyl phthalate induces modifications in the morphology and the gene expression profile of the mammary gland: an experimental study in rats
    Raquel Moral
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Environ Health 10:5. 2011
    ..The aim of this study was to elucidate the effect of prenatal exposure to BBP on the morphology, proliferative index, and genomic signature of the rat mammary gland at different ages...
  67. ncbi Comparative assessment of human exposure to phthalate esters from house dust in China and the United States
    Ying Guo
    Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, United States
    Environ Sci Technol 45:3788-94. 2011
    ..This is the first study to elucidate sources of human exposure to phthalates among the general population in China...
  68. ncbi Occurrence of phthalate esters in water and sediment of urban lakes in a subtropical city, Guangzhou, South China
    Feng Zeng
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangdong, Guangzhou 51027, China
    Environ Int 34:372-80. 2008
    ..01), and that DiBP was a predictive indicator for the sediment summation operator16 PAEs concentration (r=0.975, p<0.01). As compared to the results for other studies, the urban lakes of Guangzhou were moderately polluted by PAEs...
  69. ncbi Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Anal Toxicol 34:400-10. 2010
    ..In seminal plasma, only MEP levels correlated significantly to levels in urine and in serum...
  70. ncbi The internal exposure of Taiwanese to phthalate--an evidence of intensive use of plastic materials
    Mei Lien Chen
    Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang Ming University, Taipei, Taiwan
    Environ Int 34:79-85. 2008
    ..We conclude that the body burden of DEHP for Taiwanese reflects the intensives use of plastic materials in the region. The regulation of PVC for food preparation is necessary...
  71. pmc The association between phthalates in dust and allergic diseases among Bulgarian children
    Barbara Kolarik
    Technical University of Denmark, Department of Mechanical Engineering, International Centre for Indoor Environment and Energy, Lyngby, Denmark
    Environ Health Perspect 116:98-103. 2008
    ..Recent studies have identified associations between the concentration of phthalates in indoor dust and allergic symptoms in the airways, nose, and skin...
  72. pmc Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth
    Malene Boas
    Department of Growth and Reproduction, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 118:1458-64. 2010
    ..Phthalates are widely used chemicals, and human exposure is extensive. Recent studies have indicated that phthalates may have thyroid-disrupting properties...
  73. ncbi Distribution of phthalate esters in alluvial sediment: a case study at JiangHan Plain, Central China
    Hui Liu
    Key Laboratory of Biogeology and Environmental Geology of Ministry of Education and School of Environmental Studies, China University of Geosciences, Wuhan 430074, China
    Chemosphere 78:382-8. 2010
    ..On the other hand, DEHP, DnBP, and DiBP could be transported into deep sediment along with the horizontal flow of shallow groundwater from surface water, such as Yangtze River, Hanjiang River, and Honghu Lake...
  74. pmc Prenatal exposure to phthalates and infant development at 6 months: prospective Mothers and Children's Environmental Health (MOCEH) study
    Yeni Kim
    Department of Adolescent Psychiatry, National Center for Child and Adolescent Psychiatry, Seoul National Hospital, Seoul, Korea
    Environ Health Perspect 119:1495-500. 2011
    ..There are increasing concerns over adverse effects of prenatal phthalate exposure on the neurodevelopment of infants...
  75. ncbi Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly
    P Monica Lind
    Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
    Atherosclerosis 218:207-13. 2011
    ..Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study...
  76. ncbi PVC--as flooring material--and its association with incident asthma in a Swedish child cohort study
    M Larsson
    Karlstad University, Health and Environmental Sciences, Karlstad, Sweden
    Indoor Air 20:494-501. 2010
    ..PVC-flooring was found to be a stronger risk factor for incident asthma in multifamily homes when compared with single-family houses and in smoking families compared with non-smoking families and in women...
  77. ncbi Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction
    Mariko Matsumoto
    Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Regul Toxicol Pharmacol 50:37-49. 2008
    ..However, because it is difficult to find alternative methods to examine the direct toxic effects of chemicals, animal studies remain necessary for risk assessment of chemicals including PAEs...
  78. ncbi Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats
    Julie Boberg
    Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Reprod Toxicol 31:200-9. 2011
    ..These results show that DINP causes anti-androgenic effects on reproductive development, though less potent than DEHP, DBP and BBP, and further safety evaluation of DINP appears warranted...
  79. ncbi Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development
    Cynthia V Rider
    MD 72, Endocrinology Branch, Reproductive Toxicology Division, NHEERL, ORD, U S Environmental Protection Agency, RTP, North Carolina 27713, USA
    Toxicol Pathol 37:100-13. 2009
    ..In this study, the complex mixture behaved in a dose-additive manner. Our results indicate that compounds that act by disparate mechanisms of toxicity display cumulative, dose-additive effects when present in combination...
  80. pmc Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates
    Bethany R Hannas
    National Research Council Fellowship Program, National Health and Environmental Effects Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 120:184-93. 2011
    ....
  81. ncbi Foetal exposure to phthalate esters and anogenital distance in male newborns
    Y Suzuki
    Department of Environmental Studies, The University of Tokyo, Chiba, Japan
    Int J Androl 35:236-44. 2012
    ..Urinary isoflavones did not significantly contribute to AGI in any models. Our results suggest that prenatal exposure to di(2-ethylhexyl) phthalate affects reproductive development in human males...
  82. pmc Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:739-45. 2012
    ..Gestational phthalate and bisphenol A (BPA) exposure may increase the risk of adverse maternal/child health outcomes, but there are few data on the variability of urinary biomarkers before and during pregnancy...
  83. ncbi Exposure to phthalates in 5-6 years old primary school starters in Germany--a human biomonitoring study and a cumulative risk assessment
    Holger M Koch
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Int J Hyg Environ Health 214:188-95. 2011
    ..Therefore, the overall exposure to a number of phthalates, and the knowledge that these phthalates (and other anti-androgens) act in a dose-additive manner, urgently warrants a cumulative risk assessment approach...
  84. pmc The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: a systematic review and meta-analysis
    Jouni J K Jaakkola
    Institute of Occupational and Environmental Medicine, University of Birmingham, Birmingham, United Kingdom
    Environ Health Perspect 116:845-53. 2008
    ..Phthalates from polyvinyl chloride (PVC) plastics may have adverse effects on airways and immunologic systems, but the evidence has not been reviewed systematically...
  85. ncbi A biomarker approach to measuring human dietary exposure to certain phthalate diesters
    W A Anderson
    Ministry of Agriculture Fisheries and Food, Central Science Laboratory, Sand Hutton, York, UK
    Food Addit Contam 18:1068-74. 2001
    ..These conversion factors can be used in future studies to assess exposure to phthalate esters via measuring urinary levels of the monoester metabolites...
  86. ncbi Within-person variability in urinary phthalate metabolite concentrations: measurements from specimens after long-term frozen storage
    Donna Day Baird
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Expo Sci Environ Epidemiol 20:169-75. 2010
    ..These findings support the use of stored urine specimens collected during the relevant stage of human pregnancy to investigate the influence of phthalate exposures on later outcomes...
  87. pmc Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa)
    Xibiao Ye
    Epidemiology Branch, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, MD A3 05, PO Box 12233, Research Triangle Park, NC 27709, USA
    Int J Hyg Environ Health 212:481-91. 2009
    ....
  88. pmc Relationship between environmental phthalate exposure and the intelligence of school-age children
    Soo Churl Cho
    Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Republic of Korea
    Environ Health Perspect 118:1027-32. 2010
    ..Concern over phthalates has emerged because of their potential toxicity to humans...
  89. ncbi Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats
    Kembra L Howdeshell
    Reproductive Toxicology Division, National Health and Environmental Effects Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Res 108:168-76. 2008
    ..Since phthalate ester metabolites are detected in maternal and fetal body fluids, and androgen-signaling and insl3 are highly conserved among mammals, phthalates may potentially affect human reproductive development...
  90. ncbi Association between prenatal exposure to phthalates and the health of newborns
    Po Chin Huang
    Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, Tainan, Taiwan
    Environ Int 35:14-20. 2009
    ....
  91. pmc Exposure to phthalates and breast cancer risk in northern Mexico
    Lizbeth Lopez-Carrillo
    National Institute of Public Health, Cuernavaca, Morelos, Mexico
    Environ Health Perspect 118:539-44. 2010
    ..Phthalates, ubiquitous environmental pollutants that may disturb the endocrine system, are used primarily as plasticizers of polyvinyl chloride and as additives in consumer and personal care products...
  92. pmc Medications as a source of human exposure to phthalates
    Russ Hauser
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 112:751-3. 2004
    ..Further research is necessary to determine the proportional contribution of medications, as well as personal care and consumer products, to a person's total phthalate burden...
  93. pmc Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers
    Dana B Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 111:1148-51. 2003
    ....
  94. pmc Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 114:1783-9. 2006
    ..Although the vast and growing literature on phthalates research could not be covered comprehensively in this article, we made every attempt to include the most relevant publications as of the end of 2005...
  95. ncbi Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism
    Christopher J Thompson
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Endocrinology 145:1227-37. 2004
    ....
  96. ncbi Assessment of human exposure to di-isodecyl phthalate using oxidative metabolites as biomarkers
    M J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Biomarkers 12:133-44. 2007
    ..These data also suggest that unless oxidative metabolites are measured, the prevalence of exposure to DiDP will probably be underestimated...
  97. ncbi [Study on the level of phthalates in human biological samples]
    Yun Hui Zhang
    Department of Environmental Health Sciences, School of Public Health, Fudan University, Shanghai 200032, China
    Zhonghua Yu Fang Yi Xue Za Zhi 37:429-34. 2003
    ..To monitor the level of phthalates in human biological samples...
  98. ncbi Quantitative identification of unknown exposure pathways of phthalates based on measuring their metabolites in human urine
    Hiroaki Itoh
    Graduate School of Environment and Information Sciences, Yokohama National University, Tokiwadai 79 7, Hodogaya ku, Yokohama 240 8501, Japan
    Environ Sci Technol 41:4542-7. 2007
    ..The probabilities that the log normal distribution of each phthalate daily intake estimated from the present study exceeds the corresponding tolerable daily intake were estimated to be less than 10(-4)...
  99. ncbi Urinary metabolites of diisodecyl phthalate in rats
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Toxicology 236:114-22. 2007
    ..Additional research on the toxicokinetics of these metabolites is needed to understand the extent of human exposure to DiDP from the urinary concentrations of MCiNP and other DiDP secondary metabolites...
  100. ncbi Two-generation reproduction studies in Rats fed di-isodecyl phthalate
    L J Hushka
    ExxonMobil Biomedical Sciences, Inc, Annandale NJ, USA
    Reprod Toxicol 15:153-69. 2001
    ..Statistical evaluation of the data from both studies identified 108 mg/kg/day with a 95% lower bound value of 86 mg/kg/day as a theoretical NOAEL for reduced F2 offspring survival...
  101. ncbi The relationship between environmental exposure to phthalates and computer-aided sperm analysis motion parameters
    Susan M Duty
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Androl 25:293-302. 2004
    ..Although we did not find statistically significant associations, trends between CASA parameters, sperm velocity, and forward progression, and increased urinary levels of MBP, MBzP, and MEHP warrant further follow-up...

Research Grants39

  1. Maternal Phthalate Exposure and Infertility, Fetal Loss
    Russ Hauser; Fiscal Year: 2007
    ..Since occupational and environmental exposure to phthalates is widespread, detecting even small adverse effects will have large public health significance. ..
  2. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2009
    ..Since the etiology of infertility and early pregnancy loss remains largely unexplained, the identification of potential environmental risk factors will have large public health significance. ..
  3. US STUDY OF SEMEN QUALITY IN PARTNERS OF PREGNANT WOMEN
    Shanna Swan; Fiscal Year: 2001
    ....
  4. Environmental Endocrine Disrupters 2008 Gordon Research Conference
    Shanna Swan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  6. Neurotoxic Interactions of Different Forms of Mercury
    Bernard Weiss; Fiscal Year: 2007
    ..The acquisition of these data offers a firm foundation for determining the risks to neurobehavioral development of concurrent exposures to both mercury species. ..
  7. Molecular Epidemiology of Xenoestrogen Exposure
    Susan Teitelbaum; Fiscal Year: 2008
    ..Furthermore, data analysis approaches applied in this research project will be applicable to a wide range of environmentally associated diseases. ..
  8. Developmental Neurotoxicity of Phthalate Esters
    Bernard Weiss; Fiscal Year: 2008
    ..The proposed research will examine this question in rats, and translate its implications into human relevance. [unreadable] [unreadable] [unreadable]..
  9. SERTOLI CELL TOXICITY IN VIVO--MICROTUBULE DISRUPTION
    Kim Boekelheide; Fiscal Year: 2001
    ..Together, these complimentary approaches will critically examine key steps in the pathogenetic sequence by which microtubule disrupters alter the supportive capacity of Sertoli cells resulting in loss of germ cells and infertility. ..
  10. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  11. ENVIRONMENTAL/INDUSTRIAL TOXICANTS AND TESTICULAR INJURY
    Kim Boekelheide; Fiscal Year: 2003
    ..Together, these complimentary approaches will elucidate the key molecular mechanisms responsible for irreversible testicular injury. ..
  12. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53
    Kim Boekelheide; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. A Pilot Study Of Internet Recruitment and follow-up among Reproductive Age Women
    ELIZABETH HATCH; Fiscal Year: 2007
    ..If successful, we envision this study to be the first of more elaborate studies that employ the internet to enroll cohort members into long-term follow-up studies. [unreadable] [unreadable] [unreadable]..
  15. The Association between obesity, central adiposity and endocrine disruptors
    ELIZABETH HATCH; Fiscal Year: 2007
    ..Nevertheless, it may provide important clues for future, epidemiologic studies of the effect of these environmental contaminants on the risk of obesity. [unreadable] [unreadable] [unreadable]..
  16. Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood
    Kimberly Yolton; Fiscal Year: 2010
    ....
  17. Molecular Mechanisms of Phthalate-induced Carcinogenesis
    Ivan Rusyn; Fiscal Year: 2007
    ..This results in a "potentiation" of a non-specific mitogen release from Kupffer cells activated by lipid-like peroxisome proliferator particles, thus accounting for a characteristic burst of proliferation in the liver. ..
  18. Ovary Intact Murine Model for Menopause
    Patricia Hoyer; Fiscal Year: 2007
    ..Characterization of the VCD-treated mouse will, therefore, make a profound contribution to the study of menopause-related pathologies and, therefore, to women's health. ..
  19. Metabolomic and Toxicogenetic Study of Ethanol Toxicity
    Ivan Rusyn; Fiscal Year: 2009
    ..abstract_text> ..
  20. Estrogen Receptor-related Receptor Action in Zebrafish
    Ann Tarrant; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. ENVIRONMENTAL EPOXIDES--MECHANISMS OF OVOTOXICITY
    Patricia Hoyer; Fiscal Year: 2002
    ..The results of these studies will provide greater insight as to the impact of exposure to ovotoxic environmental chemicals on reproductive health in women. ..
  22. Validation of biomarkers of prenatal pesticides exposure
    Robin Whyatt; Fiscal Year: 2003
    ....
  23. CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASE
    Alicia Rivera; Fiscal Year: 2003
    ..It is additionally significant, because it will provide the means for the applicant to establish an independent research career and to become competitive for a tenure-track assistant professional position. ..
  24. LC-MS/MS Methods for Analysis of Hemoglogbin Adducts
    Timothy Fennell; Fiscal Year: 2004
    ..abstract_text> ..
  25. DNA REPAIR AND SUSCEPTIBILITY TO ENVIRONMENTAL AGENTS
    Ivan Rusyn; Fiscal Year: 2004
    ..These experiments will also provide crucial mechanistic insights into possible differences in species- and tissue-specific responses to DNA damage induced by environmental agents. ..
  26. Exploration of ETS Effects on Child Behavior and Sleep
    Kimberly Yolton; Fiscal Year: 2005
    ..abstract_text> ..
  27. Bridge to the Doctorate at UMET: Building the Next Gene*
    Beatriz Zayas; Fiscal Year: 2005
    ..Thus, for the duration of the project a grand total of 540 students will benefit from these development activities and will learn more about graduate studies in biomedical sciences. ..
  28. Prenatal Insecticide Exposures Among Urban Minorities
    Robin Whyatt; Fiscal Year: 2005
    ..The research will provide important information about pesticide exposure during pregnancy among this minority cohort. ..
  29. Cytokines in Sickle Cell Volume Regulation
    Alicia Rivera; Fiscal Year: 2006
    ..abstract_text> ..
  30. SIGNALING PATHWAYS IN CHEMICAL INDUCED OVOTOXICITY
    Patricia B Hoyer; Fiscal Year: 2010
    ..This will lead to an appreciation of the global impact of the environment on the reproductive life span in women. ..
  31. The Role of Egr-1 in GnRH Neurons
    Sara DiVall; Fiscal Year: 2005
    ..Protein-DNA binding studies will be performed on candidate regions of the GnRH promoter. This could define a link between nutritional status and reproductive competency at a molecular level. ..
  32. Cholinergic modulation of IEG expression
    ANN POWER; Fiscal Year: 2006
    ..Experiment III will investigate which signaling cascades (e.g., protein kinases) are involved in effects of mR activation on memory and immediate early gene expression. ..
  33. Isolation and Characterization of Testis Stem Cells
    Marie Claude Hofmann; Fiscal Year: 2009
    ..In particular, the role of the growth factor GDNF in regulating self-renewal and/or differentiation will be elucidated. ..
  34. Novel Approaches to Studying the Situ Bioremediation of Complex Mixtures
    ROLF HALDEN; Fiscal Year: 2009
    ..abstract_text> ..
  35. Wearable Organic Electric Film RFID Sensors for Monitoring of Airborne Toxicants
    Radislav A Potyrailo; Fiscal Year: 2010
    ..This new sensing approach will provide a wearable, cost-effective, selective sensor for de- tection of toxic volatile species. ..
  36. Metabolomics: Markers of Drug-Induced Liver Injury(RMI)
    Susan Sumner; Fiscal Year: 2008
    ..The signals defining these patterns will be identified using GC-MS, NMR, and LC-MS/MS methods and then assigned to biochemical pathways for defining the relevancy of the marker profiles to mode of action. ..
  37. Assessment of Infant Outcomes After in Utero Exposure to Antiretroviral Therapy
    Sonia Hernandez diaz; Fiscal Year: 2010
    ..We propose to evaluate the risk of congenital malformations and other adverse pregnancy outcomes following antenatal exposure to ART in a prospective cohort of pregnant women. ..
  38. REGULATION OF THE STEROIDOGENIC ACUTE REGULATORY PROTEIN
    Barbara Clark; Fiscal Year: 2005
    ..This will ultimately lead to a better understanding of potential developmental or disease states that result from aberrant over- or under-expression of StAR in a cell-specific manner. ..
  39. Indoor Environment and Symptoms in Office Building
    MARK MENDELL; Fiscal Year: 2006
    ..abstract_text> ..