ibuprofen

Summary

Summary: A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Top Publications

  1. ncbi Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
    Michael T Heneka
    Department of Neurology, University of Bonn, Bonn, Germany
    Brain 128:1442-53. 2005
  2. ncbi A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain
    Michael Doherty
    Arthritis Research UK Pain Centre, Academic Rheumatology, Nottingham City Hospital, UK
    Ann Rheum Dis 70:1534-41. 2011
  3. ncbi Tissue anti-adhesion potential of ibuprofen-loaded PLLA-PEG diblock copolymer films
    Jin Ho Lee
    Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Gu, Daejeon 306 791, Republic of Korea
    Biomaterials 26:671-8. 2005
  4. pmc Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO study
    F M Shebl
    Department of Human Health and Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Br J Cancer 107:207-14. 2012
  5. pmc Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection?--results of a randomized controlled pilot trial
    Jutta Bleidorn
    Institute of General Practice Family Medicine, Hanover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    BMC Med 8:30. 2010
  6. ncbi Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme-albumin
    Alessandra di Masi
    Department of Biology, and Interdepartmental Laboratory of Electron Microscopy, University Roma Tre, Italy
    FEBS J 278:654-62. 2011
  7. ncbi Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases
    F A Attiga
    Department of Biology, George Washington University, Washington, DC 20037, USA
    Cancer Res 60:4629-37. 2000
  8. ncbi Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever
    Elizabeth R Southey
    Watermeadow Medical, Witney, Oxfordshire, UK
    Curr Med Res Opin 25:2207-22. 2009
  9. ncbi Effect of ibuprofen and warfarin on the allosteric properties of haem-human serum albumin. A spectroscopic study
    S Baroni
    Department of Chemistry IFM, University of Torino, Italy
    Eur J Biochem 268:6214-20. 2001
  10. ncbi Ibuprofen induces an allosteric conformational transition in the heme complex of human serum albumin with significant effects on heme ligation
    Francesco P Nicoletti
    Dipartimento di Chimica, Universita di Firenze, Via della Lastruccia 3, I 50019 Sesto Fiorentino FI, Italy
    J Am Chem Soc 130:11677-88. 2008

Detail Information

Publications329 found, 100 shown here

  1. ncbi Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
    Michael T Heneka
    Department of Neurology, University of Bonn, Bonn, Germany
    Brain 128:1442-53. 2005
    ..an acute 7 day oral treatment of 10-month-old APPV717I mice with the PPARgamma agonist pioglitazone or the NSAID ibuprofen resulted in a reduction in the number of activated microglia and reactive astrocytes in the hippocampus and ..
  2. ncbi A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain
    Michael Doherty
    Arthritis Research UK Pain Centre, Academic Rheumatology, Nottingham City Hospital, UK
    Ann Rheum Dis 70:1534-41. 2011
    ..To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain...
  3. ncbi Tissue anti-adhesion potential of ibuprofen-loaded PLLA-PEG diblock copolymer films
    Jin Ho Lee
    Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Gu, Daejeon 306 791, Republic of Korea
    Biomaterials 26:671-8. 2005
    ..study was designed to evaluate the effect of polyethylene glycol (PEG) and nonsteroidal anti-inflammatory drug (ibuprofen) on the prevention of postsurgical tissue adhesion...
  4. pmc Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO study
    F M Shebl
    Department of Human Health and Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Br J Cancer 107:207-14. 2012
    ..Although most epidemiological studies suggest that non-steroidal anti-inflammatory drug use is inversely associated with prostate cancer risk, the magnitude and specificity of this association remain unclear...
  5. pmc Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection?--results of a randomized controlled pilot trial
    Jutta Bleidorn
    Institute of General Practice Family Medicine, Hanover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    BMC Med 8:30. 2010
    ..This pilot study was set out 1) to make a rough estimate of the equivalence of ibuprofen and ciprofloxacin for uncomplicated urinary tract infection with regard to symptom resolution, and 2) to ..
  6. ncbi Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme-albumin
    Alessandra di Masi
    Department of Biology, and Interdepartmental Laboratory of Electron Microscopy, University Roma Tre, Italy
    FEBS J 278:654-62. 2011
    The ibuprofen primary binding site FA3-FA4 is located in domain III of human serum albumin (HSA), the secondary clefts FA2 and FA6 being sited in domains I and II...
  7. ncbi Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases
    F A Attiga
    Department of Biology, George Washington University, Washington, DC 20037, USA
    Cancer Res 60:4629-37. 2000
    ..through Matrigel was inhibited by the PLA2 inhibitor 4-bromophenacyl bromide (4-BPB), the general COX inhibitor ibuprofen (IB), and the highly selective COX-2 inhibitor NS398. Inhibition of cell invasiveness by 4-BPB (1...
  8. ncbi Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever
    Elizabeth R Southey
    Watermeadow Medical, Witney, Oxfordshire, UK
    Curr Med Res Opin 25:2207-22. 2009
    The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age.
  9. ncbi Effect of ibuprofen and warfarin on the allosteric properties of haem-human serum albumin. A spectroscopic study
    S Baroni
    Department of Chemistry IFM, University of Torino, Italy
    Eur J Biochem 268:6214-20. 2001
    ..Here, the effect of ibuprofen and warfarin on the spectroscopic properties of ferric haem-human serum albumin (ferric HSA-haem) and of ferrous ..
  10. ncbi Ibuprofen induces an allosteric conformational transition in the heme complex of human serum albumin with significant effects on heme ligation
    Francesco P Nicoletti
    Dipartimento di Chimica, Universita di Firenze, Via della Lastruccia 3, I 50019 Sesto Fiorentino FI, Italy
    J Am Chem Soc 130:11677-88. 2008
    ..Heme-HSA, heme, and their complexes with ibuprofen have been characterized by electronic absorption, resonance Raman, and electron paramagnetic resonance (EPR) ..
  11. ncbi Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model
    D Van Dam
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Department of Biomedical Sciences, Wilrijk, Belgium
    J Psychopharmacol 24:383-8. 2010
    ..cognitive decline in the APP23 transgenic mouse model for AD to evaluate disease-modifying efficacy of chronic ibuprofen treatment at the cognitive level...
  12. pmc Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial
    Alastair D Hay
    Academic Unit of Primary Health Care, NIHR National School for Primary Care Research, Department of Community Based Medicine, University of Bristol, Bristol BS8 2AA
    BMJ 337:a1302. 2008
    To investigate whether paracetamol (acetaminophen) plus ibuprofen are superior to either drug alone for increasing time without fever and the relief of fever associated discomfort in febrile children managed at home.
  13. ncbi Ibuprofen inhibition of tendon cell proliferation and upregulation of the cyclin kinase inhibitor p21CIP1
    Wen Chung Tsai
    Department of Physical Medicine and Rehabilitation, Graduate Institute of Clinical Medical Sciences, Chang Gung Memorial Hospital, Chang Gung University, Building J, 12F, 5 Fu Shing Street, Kweishan, Taoyuan 333, Taiwan
    J Orthop Res 22:586-91. 2004
    ..This study was designed to determine the in vitro effect of ibuprofen on the proliferation of tendon cells intrinsic to rat Achilles tendon...
  14. pmc A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg: effect on swelling and other postoperative events after third molar surgery
    G A Bjørnsson
    Section of Dental Pharmacology and Pharmacotherapy, University of Oslo, N 0316 Oslo, Norway
    Br J Clin Pharmacol 55:405-12. 2003
    To evaluate the effect of a 3-day regimen of ibuprofen 600 mg x 4 on acute postoperative swelling and pain and other inflammatory events after third molar surgery compared with a traditional regimen of paracetamol 1000 mg x 4.
  15. ncbi Physiological effects of diclofenac, ibuprofen and propranolol on Baltic Sea blue mussels
    Hanna Ericson
    Department of Systems Ecology, Stockholm University, Svante Arrhenius Väg 21A, S 106 91 Stockholm, Sweden
    Aquat Toxicol 99:223-31. 2010
    ..In this study, Baltic Sea blue mussels, Mytilus edulis trossulus, were exposed to diclofenac, ibuprofen and propranolol, three pharmaceuticals that are produced and sold in large quantities and have a widespread ..
  16. pmc NSAID inhibition of prostate cancer cell migration is mediated by Nag-1 Induction via the p38 MAPK-p75(NTR) pathway
    Shehla Wynne
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Mol Cancer Res 8:1656-64. 2010
    The nonsteroidal anti-inflammatory drugs (NSAID) R-flurbiprofen and ibuprofen have been shown to induce expression of p75(NTR) (neurotrophin receptor) in prostate cancer cell lines...
  17. pmc The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats
    L Huang
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY, USA
    Br J Pharmacol 162:1521-33. 2011
    ..We evaluated the anti-inflammatory efficacy and safety of three novel modified NSAIDs, phospho-aspirin, phospho-ibuprofen and phospho-sulindac.
  18. ncbi Optimization of ibuprofen gel formulations using experimental design technique for enhanced transdermal penetration
    Yun Seok Rhee
    College of Pharmacy, Sungkyunkwan University, 300 Cheoncheon dong, Jangan gu, Suwon, Gyeonggi do 440 746, Republic of Korea
    Int J Pharm 364:14-20. 2008
    The aims of this study were to develop a transdermal gel formulation for ibuprofen using experimental design techniques and to evaluate its pharmacokinetic properties...
  19. ncbi Aspirin, acetaminophen, and ibuprofen: their effects on orthodontic tooth movement
    Oscar R Arias
    Department of Orthodontics, Universidad Intercontinental, Mexico DF, Mexico
    Am J Orthod Dentofacial Orthop 130:364-70. 2006
    ..The purposes of this study were to determine by direct measurement the effects that acetylsalicylic acid, ibuprofen, and acetaminophen have on orthodontic tooth movement in rats and to evaluate histologically the differences in ..
  20. pmc Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site
    Karel Berka
    Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University, Olomouc, Czech Republic
    J Phys Chem A 115:11248-55. 2011
    ..The positions of openings of the substrate access and product egress channels correspond to free energy minima of CYP2C9 substrate ibuprofen and its metabolite in the membrane, respectively.
  21. ncbi The efficacy comparison of ibuprofen, acetaminophen-codeine, and placebo premedication therapy on the depth of anesthesia during treatment of inflamed teeth
    Jalil Modaresi
    Department of Endodontics, Dental School, Shahid Sadoughi University of Medical Sciences, Yazd and Isfahan, Iran
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:399-403. 2006
    The purpose of this study was to elucidate whether premedication therapy with acetaminophen-codeine or ibuprofen is able to increase the depth of anesthesia in inflamed teeth...
  22. pmc A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy
    Clara Sciorati
    San Raffaele Scientific Institute, Division of Regenerative Medicine, Via Olgettina 58, 20132 Milan, Italy
    Pharmacol Res 64:210-7. 2011
    ..are recognized key pathogenic events in muscular dystrophy, we have analysed the effects of a derivative of ibuprofen, NCX 320, belonging to the class of cyclooxygenase inhibiting nitric oxide donator (CINOD), in the α-..
  23. ncbi Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism
    Morten Søndergaard Jensen
    Perinatal Epidemiology Research Unit, Departments of Obstetrics and Pediatrics, Aarhus University Hospital, Skejby, Denmark
    Epidemiology 21:779-85. 2010
    Cyclooxygenase (COX) inhibitors-acetaminophen, ibuprofen and acetylsalicylic acid-have endocrine-disruptive properties in the rainbow trout...
  24. pmc Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models
    Gang Xie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794 8173, USA
    J Pharmacol Exp Ther 337:876-86. 2011
    ..Phospho-ibuprofen [(PI) 2-(4-isobutyl-phenyl)-propionic acid-4-(diethoxy-phosphoryloxy)-butyl ester (MDC-917)], a novel derivative ..
  25. ncbi Effects of human serum albumin, ibuprofen and N-acetyl-L-cysteine against biofilm formation by pathogenic Escherichia coli strains
    P Naves
    Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacion Jimenez Diaz Capio, Madrid, Spain
    J Hosp Infect 76:165-70. 2010
    The aim of this study was to evaluate the effects of human serum albumin (HSA), ibuprofen sodium (IBU) and N-acetyl-L-cysteine (NAC) against biofilm formation by seven biofilm-producing strains of Escherichia coli...
  26. pmc Use of ibuprofen and risk of Parkinson disease
    Xiang Gao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Neurology 76:863-9. 2011
    ..Use of nonsteroidal anti-inflammatory drugs (NSAID) in general, and possibly ibuprofen in particular, has been shown to be related to lower PD risk in previous epidemiologic studies.
  27. ncbi Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review
    Catherine A Pierce
    Critical Care Specialty Residency Department of Pharmacy, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Ann Pharmacother 44:489-506. 2010
    To evaluate the analgesic and antipyretic efficacy and safety of ibuprofen compared to acetaminophen in children and adults.
  28. pmc Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity
    Chi C Wong
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8173, USA
    J Pharmacol Exp Ther 340:422-32. 2012
    ..Kinetic analysis revealed that CES1 is more active in the hydrolysis of phospho-sulindac, phospho-ibuprofen, phospho-naproxen, phospho-indomethacin, and phospho-tyrosol-indomethacin that possessed a bulky acyl moiety, ..
  29. ncbi Asthma morbidity after the short-term use of ibuprofen in children
    Samuel M Lesko
    Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Boston, Massachusetts 02215, USA
    Pediatrics 109:E20. 2002
    To test the hypothesis that short-term use of ibuprofen increases asthma morbidity in children.
  30. ncbi Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis
    S Tsutsumi
    Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Cell Death Differ 11:1009-16. 2004
    ..NSAIDs other than indomethacin (diclofenac, ibuprofen and celecoxib) also induced CHOP...
  31. ncbi Duration of treatment with nonsteroidal anti-inflammatory drugs and impact on risk of death and recurrent myocardial infarction in patients with prior myocardial infarction: a nationwide cohort study
    Anne Marie Schjerning Olsen
    Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark
    Circulation 123:2226-35. 2011
    ..We therefore studied the duration of NSAID treatment and cardiovascular risk in a nationwide cohort of patients with prior myocardial infarction (MI)...
  32. pmc Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults
    Todd A Trappe
    Human Performance Laboratory, Ball State Univ, Muncie, IN 47306, USA
    Am J Physiol Regul Integr Comp Physiol 300:R655-62. 2011
    ..This study examined the influence of acetaminophen or ibuprofen consumption on muscle mass and strength during 12 wk of knee extensor progressive resistance exercise training ..
  33. pmc Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}
    Emily J Greenspan
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Cancer Prev Res (Phila) 4:161-71. 2011
    ..In this study, we investigated the effects of long-term use (up to 25 years) of NSAIDs (ibuprofen or aspirin) on adenoma pathology and β-catenin-mediated signaling in sporadic human colon adenomas...
  34. ncbi Management of fever in children: summary of the Italian Pediatric Society guidelines
    Elena Chiappini
    Department of Pediatrics, University of Florence, I 50139 Florence, Italy
    Clin Ther 31:1826-43. 2009
    ..This article summarizes the Italian Pediatric Society guideline on the management of the signs and symptoms of fever in children, prepared as part of the National Guideline Program (NGLP)...
  35. ncbi Continuous low-level topical heat in the treatment of dysmenorrhea
    M D Akin
    Health Quest Therapy and Research Institute, Austin, Texas, USA
    Obstet Gynecol 97:343-9. 2001
    OBJECTIVE: To compare the efficacy of topically applied heat for menstrual pain with oral ibuprofen and placebo treatment...
  36. ncbi Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin
    Jagan Mohan R Parepally
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    Pharm Res 23:873-81. 2006
    To determine the roles of blood-brain barrier (BBB) transport and plasma protein binding in brain uptake of nonsteroidal anti-inflammatory drugs (NSAIDs)-ibuprofen, flurbiprofen, and indomethacin.
  37. ncbi Displacement of bilirubin from albumin by ibuprofen in vitro
    Hanne T Soligard
    Department of Cancer Research and Molecular Medicine, Children s and Women s Health, Faculty of Medicine, Norwegian University of Science and Technology, and Department of Pediatrics and Adolescent Medicine, St Olavs University Hospital, Trondheim, N 7006, Norway
    Pediatr Res 67:614-8. 2010
    b>Ibuprofen binds to plasma albumin and could interfere with the binding of bilirubin in jaundiced newborn infants...
  38. ncbi Assessment of full-scale natural systems for the removal of PPCPs from wastewater in small communities
    María Hijosa-Valsero
    Department of Applied Chemistry and Physics, Faculty of Biological and Environmental Sciences, University of Leon, Campus de Vegazana s n, E 24071, Spain
    Water Res 44:1429-39. 2010
    ..In addition, the enantiomeric behaviour of ibuprofen was studied in all the subsystems...
  39. pmc Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease
    Brandy L Wilkinson
    Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4928, USA
    Neurobiol Aging 33:197.e21-32. 2012
    ..40 mice resulted in 90% decrease in plaque burden and a similar reduction in microglial activation. Ibuprofen treatment reduced levels of lipid peroxidation, tyrosine nitration, and protein oxidation, demonstrating a ..
  40. ncbi Ibuprofen inhibition of tendon cell migration and down-regulation of paxillin expression
    Wen Chung Tsai
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Building J, 12F, 5 Fu Shin Street, Kweishan, Taoyuan 333, Taiwan
    J Orthop Res 24:551-8. 2006
    ..This study was designed to determine the effect of ibuprofen on the migration of tendon cells intrinsic to rat Achilles tendon...
  41. pmc Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid
    Jeffery J Prusakiewicz
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 48:7353-5. 2009
    b>Ibuprofen and mefenamic acid are weak, competitive inhibitors of cyclooxygenase-2 (COX-2) oxygenation of arachidonic acid (AA) but potent, noncompetitive inhibitors of 2-arachidonoylglycerol (2-AG) oxygenation...
  42. ncbi Effect of ibuprofen on bilirubin-albumin binding in vitro at concentrations observed during treatment of patent ductus arteriosus
    C Diot
    SGS Cephac Europe, Saint Benoît Cedex, France
    Early Hum Dev 86:315-7. 2010
    In vitro studies have shown that ibuprofen (IBU) may interfere with bilirubin-albumin binding at concentrations of 100 microg/mL and above.
  43. ncbi Aggravation of exercise-induced intestinal injury by Ibuprofen in athletes
    Kim van Wijck
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    Med Sci Sports Exerc 44:2257-62. 2012
    ..The aim of the current study was to determine the effect of oral ibuprofen administration before exercise on GI integrity and barrier function in healthy individuals.
  44. ncbi Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated Abeta(1-42) injections in the rat
    R L Richardson
    School of Psychology, University of Ulster, Shore Road, Newtownabbey, Co Antrim, BT37 0QB, N Ireland, UK
    Brain Res 954:1-10. 2002
    ..Subgroups were treated twice daily with 0.1 ml (40 mg/kg) ibuprofen administered orally...
  45. ncbi Experience-dependent brain plasticity after stroke: effect of ibuprofen and poststroke delay
    Jan A Jablonka
    Department of Animal Physiology, Faculty of Biology, Warsaw University, Warsaw, Poland
    Eur J Neurosci 36:2632-9. 2012
    ..When chronic treatment with the anti-inflammatory drug ibuprofen (10 mg/kg or 20 mg/kg) accompanied deprivation, plasticity was restored...
  46. ncbi Protective effects of ibuprofen on testicular torsion/detorsion-induced ischemia/reperfusion injury in rats
    Dikmen Dokmeci
    Department of Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Arch Toxicol 81:655-63. 2007
    The aim of this study was to investigate the protective effect of ibuprofen on testicular torsion/detorsion-induced ischemia/reperfusion (I/R) injury...
  47. ncbi Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH
    Sandra Holt
    Department of Pharmacology and Clinical Neuroscience, Umea University, 901 87 Umea, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 367:237-44. 2003
    ..4, did not affect the uptake. Anandamide uptake was inhibited by (R)-ibuprofen, with pI(50) values of 3.05+/-0.57, 3.66+/-0.23 and 3.94+/-0.88 at pH(e) values of 7.4, 6.8 and 6...
  48. ncbi Fever management: evaluating the use of ibuprofen and paracetamol
    Jodie Crook
    A and E Department, Ealing Hospital NHS Trust, London
    Paediatr Nurs 22:22-6. 2010
    Paracetamol and ibuprofen are safe and effective medications for reducing a fever in children and young people and they are often administered together with a view to reducing a temperature quickly...
  49. ncbi Ibuprofen modulates allosterically NO dissociation from ferrous nitrosylated human serum heme-albumin by binding to three sites
    Paolo Ascenzi
    Department of Biology and Interdepartmental Laboratory for Electron Microscopy, University Roma Tre, Via della Vasca Navale 79, Rome, Italy
    Biochem Biophys Res Commun 387:83-6. 2009
    Human serum albumin (HSA) is a monomeric allosteric protein. Here, the effect of ibuprofen on denitrosylation kinetics (k(off)) and spectroscopic properties of HSA-heme-Fe(II)-NO is reported. The k(off) value increases from (1.4+/-0...
  50. ncbi Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Churchill Hospital, Oxford, UK
    Pain 152:982-9. 2011
    ..third molar extraction trials: 4 with single-dose oral etoricoxib 120 mg, and 2 with paracetamol, ibuprofen, and ibuprofen plus paracetamol combinations...
  51. ncbi Enhanced rectal bioavailability of ibuprofen in rats by poloxamer 188 and menthol
    Chul Soon Yong
    College of Pharmacy, Yeungnam University, 214 1 Dae Dong, Gyongsan 712 749, South Korea
    Int J Pharm 269:169-76. 2004
    To improve the bioavailability of poorly water-soluble ibuprofen in the rectum with poloxamer and menthol, the effects of menthol and poloxamer 188 on the aqueous solubility of ibuprofen were investigated...
  52. pmc The protein binding substance ibuprofen does not affect the T1 time or partition coefficient in contrast-enhanced cardiovascular magnetic resonance
    Nadine Kawel
    Department of Radiology, University Hospital Basel, Basel, Switzerland
    J Cardiovasc Magn Reson 14:71. 2012
    ..Various factors, however, can interfere with T1 measurements. The purpose of the current study was to assess the effect of co-medication with a typical protein binding drug (ibuprofen) on T1 values in vitro and in vivo.
  53. pmc Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats
    Dan Popa
    Division of Physiology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, United States
    Respir Physiol Neurobiol 178:381-6. 2011
    ..Am. J. Physiol. Lung Cell Mol. Physiol. 296, L158-L166]. We hypothesized that blocking inflammation with ibuprofen would reduce ventilatory acclimatization to hypoxia by blocking such increases in carotid body O(2) sensitivity...
  54. pmc Modification of palm kernel oil esters nanoemulsions with hydrocolloid gum for enhanced topical delivery of ibuprofen
    Norazlinaliza Salim
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia
    Int J Nanomedicine 7:4739-47. 2012
    ..The present study investigated the modification of nanoemulsions with different hydrocolloid gums, to enhanced drug delivery of ibuprofen. The in vitro characterization of the initial and modified nanoemulsions was also studied.
  55. ncbi Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen
    C J Fowler
    Department of Pharmacology, Umea University, Sweden
    Arch Biochem Biophys 362:191-6. 1999
    ..present study, the regional distribution of the activity and its sensitivity to inhibition by the enantiomers of ibuprofen, ketorolac, and flurbiprofen has been investigated...
  56. ncbi Removal of ibuprofen and its transformation products: experimental and simulation studies
    N Collado
    LEQUIA, Laboratory of Chemical and Environmental Engineering, University of Girona, Campus Montilivi, Girona, 17071, Spain
    Sci Total Environ 433:296-301. 2012
    ..The present work focuses not only on the biodegradation of the pharmaceutical compound ibuprofen but also on its best-known TPs (i.e., carboxyl ibuprofen and both hydroxyl ibuprofen isomers)...
  57. pmc Molecular dynamics simulations of Ibuprofen binding to Abeta peptides
    E Prabhu Raman
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA
    Biophys J 97:2070-9. 2009
    Using replica exchange molecular dynamics simulations and the implicit solvent model we probed binding of ibuprofen to Abeta(10-40) monomers and amyloid fibrils...
  58. ncbi Orthotopic liver transplantation after subacute liver failure induced by therapeutic doses of ibuprofen
    Francisco Javier Rodríguez-González
    Am J Gastroenterol 97:2476-7. 2002
  59. ncbi Preparation of ibuprofen-loaded liquid suppository using eutectic mixture system with menthol
    Chul Soon Yong
    College of Pharmacy, Yeungnam University, 214 1, Dae Dong, Gyongsan 712 749, South Korea
    Eur J Pharm Sci 23:347-53. 2004
    To prepare an ibuprofen-loaded liquid suppository using eutectic mixture with menthol, the effects of menthol and poloxamer 188 (P 188) on the aqueous solubility of ibuprofen were investigated...
  60. ncbi Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity
    Omar Cauli
    Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurosci Res 87:1369-74. 2009
    ..The aim of this work was to assess whether treatment with an antiinflammatory, ibuprofen, is able to normalize extracellular glutamate in SNr and/or to improve hypokinesia in PCS rats...
  61. ncbi Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: in vitro diffusion studies
    Eliane Trovatti
    CICECO and Department of Chemistry, University of Aveiro, 3810 193 Aveiro, Portugal
    Int J Pharm 435:83-7. 2012
    ..therapeutic feasibility, the permeation through human epidermis of two model drugs (lidocaine hydrochloride and ibuprofen) in BC and other formulation systems was compared in vitro...
  62. ncbi Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents
    Carrie K Jones
    Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Eur J Pain 11:208-15. 2007
    ..a balanced serotonergic and noradrenergic reuptake inhibitor, and the non-steroidal anti-inflammatory drug ibuprofen was simply additive, less than additive, or greater than additive (i.e...
  63. ncbi Hydroxyl radical induced degradation of ibuprofen
    Erzsébet Illés
    Institute of Chemistry, Research Group of Environmental Chemistry, University of Szeged, Szeged, Hungary
    Sci Total Environ 447:286-92. 2013
    Pulse radiolysis experiments were used to characterize the intermediates formed from ibuprofen during electron beam irradiation in a solution of 0.1mmoldm(-3)...
  64. ncbi Does Ibuprofen increase neonatal hyperbilirubinemia?
    Enrico Zecca
    Division of Neonatology, Department of Pediatrics, University Hospital A Gemelli, Catholic University of the Sacred Heart, Rome, Italy
    Pediatrics 124:480-4. 2009
    The aim of this study was to investigate whether ibuprofen exposure was associated with increased hyperbilirubinemia in preterm infants.
  65. ncbi Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus
    Tulin Gokmen
    Zekai Tahir Burak Maternity Teaching Hospital, Neonatal Intensive Care Unit, Ankara, Turkey
    J Pediatr 158:549-554.e1. 2011
    To compare oral ibuprofen with intravenous ibuprofen for closure of patent ductus arteriosus in very low birth weight (VLBW) preterm infants.
  66. ncbi New solid lipid microparticles for controlled ibuprofen release: formulation and characterization study
    Laurent Perge
    Institut Charles Gerhardt Montpellier UMR 5253 CNRS UM2 ENSCM UM1, Matériaux Avancés pour Catalyse et Santé, ENSCM, 8 rue de l Ecole Normale, 34296 Montpellier Cedex 5, France
    Int J Pharm 422:59-67. 2012
    A hot melt dispersion method was used to prepare new sustained release ibuprofen composite microparticles of a solid lipid at ambient temperature, cetyl alcohol...
  67. ncbi Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial
    Lisa A Jackson
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Pediatrics 117:620-5. 2006
    ..It is not known whether these reactions can be prevented with prophylactic use of acetaminophen or ibuprofen.
  68. ncbi Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis
    Matthew C Becker
    Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA
    Am Heart J 157:606-12. 2009
    ..Pain management in patients with osteoarthritis or rheumatoid arthritis often requires long-term use of nonsteroidal antiinflammatory drugs (NSAIDs). However, the relative cardiovascular safety of these therapies remains uncertain...
  69. pmc Formation of catechols via removal of acid side chains from ibuprofen and related aromatic acids
    Robert W Murdoch
    Institute for Comparative and Environmental Toxicology, Cornell University, Ithaca, NY 14850, USA
    Appl Environ Microbiol 71:6121-5. 2005
    Although ibuprofen [2-(4-isobutylphenyl)-propionic acid] is one of the most widely consumed drugs in the world, little is known regarding its degradation by environmental bacteria. Sphingomonas sp...
  70. ncbi Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization
    Jennifer Manley
    Graduate Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
    Ann Pharmacother 41:1227-32. 2007
    To evaluate the literature examining prophylactic use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization.
  71. ncbi PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States)
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, 84108, USA
    Cancer Causes Control 17:239-49. 2006
    ..98); differences in Ki-ras mutations were not seen in colon tumors by PPARgamma genotype. Those who did not take ibuprofen-type drugs and had the PA or AA genotypes were at a significantly greater risk of rectal cancer (OR 2...
  72. ncbi Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin
    Alvaro Vargas
    Santo Tomás University, Veterinary Medical School, Santiago, Chile
    Biol Res 44:161-7. 2011
    ..a.s.l.). The anti-inflammatory drug Ibuprofen was administered to a group of mice to control vasodilation and increased blood flow...
  73. ncbi Apoptosis in ibuprofen-induced Stevens-Johnson syndrome
    Manuela Neuman
    In Vitro Drug Safety and Biotechnology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Transl Res 149:254-9. 2007
    ..to analyze the reliability and correlation between the clinical symptoms observed in a patient that presented an ibuprofen-induced Stevens-Johnson Syndrome (SJS), her lymphocyte toxicity assay to the incriminated drug, and the cytokine ..
  74. ncbi Effect of ibuprofen on osteoblast differentiation of porcine bone marrow-derived progenitor cells
    Harutsugi Abukawa
    Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan
    J Oral Maxillofac Surg 67:2412-7. 2009
    ..The purpose of this study was to determine the effect of ibuprofen on osteoblast differentiation and proliferation in a minipig model.
  75. ncbi Effect of acetaminophen, ibuprofen and methylprednisolone on different parameters of human osteoblast-like cells
    Olga García-Martínez
    School of Health Sciences, University of Granada, Spain
    Arch Oral Biol 56:317-23. 2011
    ..However, their effects on bone level are not well known, and results of the scant studies in humans have been contradictory...
  76. ncbi Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat
    Shamsherjit Kaur
    Department of Pharmacology, ISF College of Pharmacy, Moga, 142001, Punjab, India
    Inflammopharmacology 19:265-72. 2011
    ..The present study was designed to investigate the anti-inflammatory and antihyperalgesic effects of the prophylactic use of hemin alone and/or in combination with ibuprofen using adjuvant-induced arthritis in Wistar rat.
  77. ncbi Non-steroidal anti-inflammatory drug use and colorectal polyps in the Prostate, Lung, Colorectal, And Ovarian Cancer Screening Trial
    Christine Cole Johnson
    Department of Biostatistics and Research Epidemiology, Josephine Ford Cancer Center, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Gastroenterol 105:2646-55. 2010
    ....
  78. pmc A comparison of the effects of ibuprofen and rofecoxib on rabbit fibula osteotomy healing
    J Patrick O'Connor
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Acta Orthop 80:597-605. 2009
    ..We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-..
  79. ncbi Formulation and evaluation of reconstitutable suspensions containing ibuprofen-loaded Eudragit microspheres
    Burcu Devrim
    Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Tandogan, Ankara, Turkey
    Acta Pol Pharm 68:593-9. 2011
    The objective of this work was to develop and evaluate reconstitutable suspensions of ibuprofen-loaded microspheres prepared with an acrylic polymer (Eudragit RS-PM)...
  80. ncbi Cost-effectiveness of low-level heat wrap therapy for low back pain
    Adam Lloyd
    Fourth Hurdle Consulting Ltd, London, UK
    Value Health 7:413-22. 2004
    To evaluate the cost-effectiveness and budget impact of a new heat wrap therapy for low back pain compared to paracetamol and ibuprofen from the perspective of the UK National Health Service (NHS).
  81. pmc Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans
    Clara Sciorati
    San Raffaele Scientific Institute, Stem Cell Research Institute, Milan, Italy
    Br J Pharmacol 160:1550-60. 2010
    ..and defects of nitric oxide (NO) generation are key pathogenic events in muscular dystrophies, we have studied the effects of combining the NO donor isosorbide dinitrate (ISDN) and the non-steroidal anti-inflammatory drug ibuprofen.
  82. ncbi Efficacy and tolerability of nonprescription ibuprofen versus celecoxib for dental pain
    Geraldine Doyle
    Clinical Research Department, Wyeth Consumer Healthcare, Madison, New Jersey 07940, USA
    J Clin Pharmacol 42:912-9. 2002
    ..This study was designed to compare the safety and analgesic efficacy of an over-the-counter (OTC) analgesic, ibuprofen (Advil Liqui-Gels), to the leading prescription COX-2 inhibitor celecoxib (Celebrex)...
  83. pmc In vitro permeation and in vivo anti-inflammatory and analgesic properties of nanoscaled emulsions containing ibuprofen for topical delivery
    Ghassan Z Abdullah
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
    Int J Nanomedicine 6:387-96. 2011
    ..As a topical delivery system, a nanoscaled emulsion is considered a good carrier of several active ingredients that convey several side effects upon oral administration, such as nonsteroidal anti-inflammatory drugs (NSAIDs)...
  84. ncbi Effects of acetyl salycilic acid and ibuprofen in chronic liver damage induced by CCl4
    Enrique Chávez
    Departamento de Farmacologia, CINVESTAV IPN, Apdo Postal 14 740, Mexico, 07000, D F Mexico
    J Appl Toxicol 32:51-9. 2012
    ..The aim of this work was to evaluate the effects of two of the most used NSAIDs, acetyl salicylic acid (ASA) and ibuprofen (IBP), on experimental liver fibrosis...
  85. ncbi Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology and Genetics, School of Biological Sciences, University of Extremadura, Badajoz, Spain
    Clin Pharmacol Ther 76:119-27. 2004
    Our objective was to identify genetic factors related to interindividual variability in the pharmacokinetics of ibuprofen and its enantiomers.
  86. pmc Timing of ibuprofen use and bone mineral density adaptations to exercise training
    Wendy M Kohrt
    Department of Medicine, Division of Geriatric Medicine, University of Colorado Denver, Denver, CO 80045, USA
    J Bone Miner Res 25:1415-22. 2010
    ..They were randomized to take (1) ibuprofen (400 mg) before exercise, placebo after (IBUP/PLAC), (2) placebo before, ibuprofen after (PLAC/IBUP), or (3) ..
  87. ncbi Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility
    Sriharsha Gupta Potta
    Medway School of Science, University of Greenwich, Chatham Maritime ME4 4TB, Kent, UK
    J Microencapsul 28:74-81. 2011
    Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH)...
  88. ncbi Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain
    M Palangio
    Medical Affairs Department, Knoll Pharmaceutical Company, Mount Olive, New Jersey 07828 1234, USA
    Clin Ther 22:879-92. 2000
    The objective of this study was to compare the effectiveness of combination hydrocodone 7.5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain.
  89. ncbi The effects of ibuprofen on muscle hypertrophy, strength, and soreness during resistance training
    Joel R Krentz
    College of Kinesiology, University of Saskatchewan, Saskatoon, Canada
    Appl Physiol Nutr Metab 33:470-5. 2008
    High doses of ibuprofen have been shown to inhibit muscle protein synthesis after a bout of resistance exercise...
  90. ncbi Topical application of compound Ibuprofen suppresses pain by inhibiting sensory neuron hyperexcitability and neuroinflammation in a rat model of intervertebral foramen inflammation
    Zhi Jiang Huang
    Department of Neurobiology, Parker Research Institute, 2500 Walnut Hill Lane, Dallas, TX 75229, USA
    J Pain 12:141-52. 2011
    ..We investigated analgesic effects and underlying mechanisms of topical application of a compound ibuprofen cream (CIC) onto the surface of back skin covering the inflamed L(5) IVF in a rat model...
  91. ncbi Superior effectiveness of ibuprofen compared with other NSAIDs for reducing the survival of human prostate cancer cells
    John Andrews
    Department of Cell Biology, Georgetown University School of Medicine, 3900 Reservoir Road N W, Washington, DC 20007, USA
    Cancer Chemother Pharmacol 50:277-84. 2002
    ..In the present investigation, we evaluated the effects of widely used nonprescription NSAIDs on human prostate cancer cells in vitro...
  92. ncbi Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies
    Khaled R A Abdellatif
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta, Canada
    Bioorg Med Chem Lett 19:3014-8. 2009
    ..14a-c), NO-donor moiety is directly attached to the carboxylic acid group of aspirin, indomethacin or ibuprofen were synthesized...
  93. ncbi Ibuprofen augments pro-inflammatory cytokine release in a mouse model of Vibrio vulnificus infection
    Yuarn Jang Lee
    Section of Infectious Diseases, Department of Internal Medicine, Taipei Medical University Hospital, 252 Wu Hsing Street, Taipei, Taiwan
    Microbiol Immunol 54:542-50. 2010
    We evaluated the effects of ibuprofen on cytokine production and mortality in a mouse model of septic shock induced by Vibrio vulnificus, strain Chi Mei Vv05191...
  94. ncbi Antiatherosclerotic activity of ibuprofen, a non-selective COX inhibitor--an animal study
    J K Dabhi
    L M College of Pharmacy, Opp Gujarat University, Navarangpura, Ahmedabad, India
    Indian J Exp Biol 46:476-81. 2008
    ..disorder, the present study was undertaken to investigate the effectiveness of anti-inflammatory drugs (ibuprofen, aspirin, and celecoxib) in hypercholesterolemia...
  95. ncbi Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training
    S G Petersen
    Institute of Sports Medicine Copenhagen, Faculty of Health Sciences, Bispebjerg Hospital, University of Copenhagen, Denmark
    Osteoarthritis Cartilage 18:34-40. 2010
    ..c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo.
  96. ncbi A second course of ibuprofen is effective in the closure of a clinically significant PDA in ELBW infants
    Justin Richards
    Neonatal Intensive Care Unit, Guy s and St Thomas National Health Service Foundation Trust, London, United Kingdom
    Pediatrics 124:e287-93. 2009
    There are few published data on the efficacy of ibuprofen in the most immature infants and no data on repeated courses...
  97. ncbi Ibuprofen in very preterm infants impairs renal function for the first month of life
    Rachel Vieux
    Maternite Regionale, Neonatal Department, Nancy University, Nancy, France
    Pediatr Nephrol 25:267-74. 2010
    We carried out a study aiming to determine the renal effect of ibuprofen treatment for patent ductus arteriosus (PDA) in very preterm infants during the first month of life...
  98. ncbi Prophylactic ibuprofen versus placebo in very premature infants: a randomised, double-blind, placebo-controlled trial
    V Gournay
    Service de réanimation pédiatrique et néonatale, hôpital de la Mère et de l Enfant, Centre Hospitalier Universitaire CHU de Nantes, quai Moncousu, 44000 Nantes, France
    Lancet 364:1939-44. 2004
    ..This benefit could be improved with ibuprofen, another cyclo-oxygenase inhibitor with fewer adverse effects than indometacin on renal, mesenteric, and ..
  99. ncbi The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    J Cancer Res Clin Oncol 128:525-32. 2002
    ..NNK, we have analyzed these tumors for mutations in the ras and p53 genes and tested the modulating effects of the COX inhibitor, ibuprofen, and the FLAP inhibitor, MK886, on the development of pancreatic cancer in this animal model.
  100. pmc Clinical trial: comparison of ibuprofen-phosphatidylcholine and ibuprofen on the gastrointestinal safety and analgesic efficacy in osteoarthritic patients
    F L Lanza
    Houston Institute of Clinical Research, Houston, TX, USA
    Aliment Pharmacol Ther 28:431-42. 2008
    ..Chronic use of NSAIDs is associated with gastrointestinal (GI) toxicity that increases with age...
  101. ncbi Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer
    Min Yao
    Section of Gastroenterology, Boston University School of Medicine and Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
    Clin Cancer Res 11:1618-28. 2005
    To determine whether the nonselective and relatively inexpensive nonsteroidal anti-inflammatory drug ibuprofen would be effective in inhibiting colorectal cancer and might improve mortality in a mouse model.

Research Grants62

  1. A fully validated assay to identify activators of ERSR in human glioma cells: ide
    Maurizio Grimaldi; Fiscal Year: 2012
    ..A second class of compounds has been developed from ibuprofen the third hit. Quinacrine modulates GRP78 resulting in glioma cell death...
  2. Ibuprofen and enteric neural crest precursor migration
    ELLEN MERRICK; Fiscal Year: 2013
    ..b>Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) commonly used in pregnancy, inhibited ENCC migration in a ..
  3. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2010
    ..Nearly all currently available non-steroidal anti-inflammatory drugs (NSAIDs), including indomethacin, naproxen, ibuprofen, and aspirin, cause significant GI damage...
  4. The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and Therapy
    Qing Jiang; Fiscal Year: 2012
    ..COX inhibitors including ibuprofen, known as non-steroid anti- inflammatory drugs (NSAIDs), have been shown to be effective anticancer agents ..
  5. NGF Receptor Regulates Prostate Growth
    Daniel Djakiew; Fiscal Year: 2009
    ..or by alternate novel mechanisms, such as by induction with select aryl propionic acids such as carprofen, ibuprofen and r-flurbiprofen, restores its growth inhibitory activity...
  6. Interventions Targeting Inflammation for Chemotherapy-Related Cognitive Problems
    MICHELLE C JANELSINS; Fiscal Year: 2013
    ..controlled, pilot study we are aware of investigating the influence of two novel interventions (exercise and ibuprofen) on CRCI and inflammation. Career Development Plan: Dr...
  7. NSAID-Phosphatidylcholine Association: Insight in GI Ulcer Pathogenesis/Therapy
    Lenard M Lichtenberger; Fiscal Year: 2010
    ..required formulation optimization, manufacturing and stability analyses of our first PC-NSAID under development (Ibuprofen-PC) by a university-based start-up company, PLx Pharma founded by the PI, to meet FDA requirements to obtain an ..
  8. NSAIDs During Postpartum Involution for Breast Cancer Chemoprevention
    Pepper J Schedin; Fiscal Year: 2013
    ..Aim 2A-Expand our preclinical studies to verify efficacy of ibuprofen in an immune competent PABC model and investigate chemopreventive strategies that can be targeted to lactating ..
  9. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..Major factors that modify the effects of other risk factors are'use of aspirin and ibuprofen-type drugs...
  10. Controlling Type 2 Diabetes with Proprietary Natural Extracts in Medical Foods
    ALEXANDER M GOSSLAU; Fiscal Year: 2013
    ..metabolites and/or biomarkers for inflammation and T2D by WG0401 and WG0301 and compare to metformin and ibuprofen. Observation of a positive correlation supports our hypothesis. Aim 3...
  11. Molecular and Clinical Pharmacology of Retinopathy of Prematurity
    Jacob V Aranda; Fiscal Year: 2013
    ..and vasoproliferation can be modulated or prevented by synergistic interventions of caffeine and systemic ibuprofen or ocular NSAID local drops...
  12. Mechanisms for NSAID Alzheimer Prevention
    Gregory M Cole; Fiscal Year: 2013
    Epidemiological studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs), notably, ibuprofen and naproxen and other non-selective cyclooxygenase (COX) inhibitors) are associated with lower risk for Alzheimer Disease (AD)...
  13. PEDIATRIC PHARMACOLOGY RESEARCH UNIT
    Mary Lieh Lai; Fiscal Year: 2009
    ..trials and has led the evaluation of drugs such as the multicenter tiral on the new formulation of intravenous ibuprofen for early closure of patent ductus artriousus in the preterm newborn...
  14. Cyclohexanehexol Therapy in Transgenic Models of Alzheimer's Disease
    Alpaslan Dedeoglu; Fiscal Year: 2013
    ..Ass peptides, especially Ass42, are thought to play a key role in the pathogenesis of AD. We found that ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) with Ass42- lowering effects, reduces Ass deposition, NFT and ..
  15. Obesity associated inflammation and postmenopausal breast cancer.
    ERIN GILES; Fiscal Year: 2013
    ..She will employ a well-established preclinical model to determine whether anti-inflammatory agents (ibuprofen) and interventions (caloric restriction or exercise) can inhibit the inflammatory response and tumor promotion ..
  16. Functional Analysis of Cyclooxygenase-2
    Lawrence J Marnett; Fiscal Year: 2013
    ..for the (R)-enantiomers of arylpropionic acid NSAIDs (profens), such as (R)-flurbiprofen, (R)-naproxen, and (R)-ibuprofen. While essentially inactive as inhibitors of AA oxygenation, these compounds are moderately potent, substrate-..
  17. Muscle function and depression-like behavior in a mouse model of cancer fatigue
    LOREN EUGENE WOLD; Fiscal Year: 2013
    ..Tumor-bearing mice will be treated with minocycline to reduce cytokine expression;ibuprofen to reduce the activity of a downstream mediator of TNFa-induced skeletal muscle wasting;fluoxetine, a selective ..
  18. Risk Factors for Hearing Loss
    Gary C Curhan; Fiscal Year: 2013
    ..Aspirin, acetaminophen and ibuprofen are the three most commonly used drugs in the U.S. The ototoxic effects of high dose salicylates are well-known...
  19. Development of a novel agent for lung cancer prevention
    Arun Kumar Sharma; Fiscal Year: 2013
    ..1,4-phenylenebis(methylene)seleno- cyanate (p-XSC) and nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin and ibuprofen, respectively, as potential agents for lung cancer prevention...
  20. Cell cycle events: outcomes measures in Alzheimer models
    Karl Herrup; Fiscal Year: 2010
    ..CCEs to NSAIDS therapies that are currently being explored for use in the treatment of Alzheimer's disease: ibuprofen, simvastatin and an new approach, GW3965, an agonist of the LXR receptor...
  21. NSAID and COX/PG Metabolism and Colorectal Cancer
    Cornelia Ulrich; Fiscal Year: 2009
    ..establish in vitro studies, which of the UGTs catalyze the glucuronidation of aspirin and other NSAIDs including ibuprofen, sulindac, sulindac sulfone, and indomethacin, and the effects of polymorphisms on metabolic capacities...
  22. Anti-inflammatory mechanisms, pharmacokinetics of novel metabolites of vitamin E
    Qing Jiang; Fiscal Year: 2012
    ..tocopherol (4T), inhibits cyclooxygenases (COX-1 and COX-2) and 5-lipoxygenase (5-LOX) with potency similar to ibuprofen (a commonly used non-steroid anti-inflammatory drugs - NSAID) and zileuton (a clinically used 5-LOX inhibitor), ..
  23. ORAL DRUG DELIVERY AND BIOAVAILABILITY--AIDS
    Gordon Amidon; Fiscal Year: 1993
    ..flow model for the systemic bioavailability variability of the beta-blocker propranolol and the NSAID ibuprofen from dogs to humans; and (5) develop a physiological micro- mixing model of the gastrointestinal tract, ..
  24. Novel Mechanisms of NSAID Action in Alzheimer's Disease
    Edward H Koo; Fiscal Year: 2013
    ..A42 in human CSF by measuring newly synthesized A through in-dwelling catheter and will test whether a GSM (ibuprofen) will reduce disease associated CSF biomarkers and brain volumetric changes by neuroimaging in AD subjects in a ..
  25. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2004
    ..pseudoephedrine, norpseudoephedrine, N-methyl ephedrine and N-methyl pseudoephedrine, the analgesics ibuprofen and naproxen, and cyclosporins and selected protein pharmaceuticals...
  26. The Role for Canonical beta-catenin Signaling in Valve Development in Mice
    Sergei G Tevosian; Fiscal Year: 2010
    ..the possibility that at least some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin or ibuprofen could interfere with valvular Wnt/ss-catenin signaling and specifically lead to cardiac valvular defects during ..
  27. PC-NSAIDs for Chemoprevention of Colorectal Cancer
    Lenard M Lichtenberger; Fiscal Year: 2013
    ..which are members of a novel class of phosphatidylcholine (PC)-associated NSAIDs for chemopreventive activity, ibuprofen (IBU- PC) and indomethacin (INDO-PC) that have been documented in preclinical studies and a pilot clinical trial ..
  28. Gastrointestinal safety and therapeutics of oil-based Phosphatidylcholine-NSAIDS
    Lenard M Lichtenberger; Fiscal Year: 2010
    ..During this period we have continued to develop our lead compounds, ibuprofen-PC and aspirin-PC, in which we chemically associate the NSAIDs with soy PC, and have demonstrated that these ..
  29. Determining Therapeutic Efficacy of AGE in AD
    Neelima Chauhan; Fiscal Year: 2005
    ..Tacrine, Aricept/Donezepil, Rivastigmine, Galantamine]; and regulation of inflammation by NSAIDs [Aspirin, Ibuprofen, Indomethacin]; COX-2 inhibitors [Celebrex, Vioxx]...
  30. COMPLEMENT-DEPENDENT PROSTAGLANDIN SYNTHESIS IN SEPSIS
    Mitchell Fink; Fiscal Year: 1991
    ..Prostaglandin synthesis will be inhibited by administering meclofenamate or ibuprofen; formation of complement-derived peptides will be inhibited by prior decomplementation with cobra venom factor ..
  31. Electroporation and transcutaneous extraction of drugs
    SATHYANARAYANA MURTHY; Fiscal Year: 2006
    ..emanates from our recent success in utilizing ETE for sampling of drugs such as salicylic acid, acyclovir, ibuprofen, fluconazole and cefpodoxime from the dermal ECF...
  32. ETIOLOGY AND CONTROL OF POSTBURN HYPERMETABOLISM
    FRED CALDWELL; Fiscal Year: 1991
    ..weekly 24 hour urinary nitrogen, E and NE excretion rates, and the effect of the cyclo-oxygenase inhibiter, ibuprofen on the febrile response and HMR of patients with burn injury...
  33. Resolutions in Branched Alkanes using Lipase in Beads
    STEVEN NEAU; Fiscal Year: 2002
    ..goal is the resolution of the pharmacologically active enantiomer of a drug that is a racemic mixture, ibuprofen, by enantioselective esterification by a lipase that is free or entrapped in the chitosan bead...
  34. PRESERVATION OF THE ISCHEMIC/REPERFUSED MYOCARDIUM
    Michael Hess; Fiscal Year: 1990
    ..of free radicals (Coenzyme Q-10 and Alpha-tocopherol) or inhibitors of free radical generation (indomethacin and ibuprofen for the cyclooxygenase system and allopurinol for the xanthine oxidase system) will protect myocardial ..
  35. STRUCTURE AND MECHANISM OF PROSTAGLANDIN H2 SYNTHASE
    PATRICK LOLL; Fiscal Year: 2002
    ..prostaglandin H2 and this process is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, naproxen, and indomethacin...
  36. GALLSTONE FORMATION & PREVENTION DURING WEIGHT REDUCTION
    JAY MARKS; Fiscal Year: 1991
    ..the efficacy of ursodeoxycholic acid in gallstone dissolution 4) the efficacy and mechanism of action of UDCA or ibuprofen (1600 mg/d) in preventing gallstones 4) the pathogenesis of the gallstones 5) the genetic predisposition to ..
  37. Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
    CATHERINE JANKOWSKI; Fiscal Year: 2007
    ..When COX activity is inhibited by non-steroidal anti- inflammatory drugs (NSAIDs), such as ibuprofen (IBUP), the bone formation response is almost completely abrogated...
  38. PHARMACOLOGIC ALTERATIONS OF SULFATE HOMEOSTASIS
    Marilyn Morris; Fiscal Year: 1993
    ..magnitude of the effect of representatives of three different classes of nonsteroidal anti-inflammatory agents (ibuprofen, mefenamic acid, piroxicam) on sulfate transport, and 3) to determine the mechanism of the renal interaction ..
  39. Inosine pro-drug: novel therapy for arthritis
    Andrew Salzman; Fiscal Year: 2004
    ..we will establish the synergy of IMS, begun on day 20, with traditional anti-arthritic therapies, including ibuprofen and methotrexate...
  40. PPAR GAMMA AGONISTS FOR THE PREVENTION OF COLON CANCER
    Michael Wargovich; Fiscal Year: 2002
    ..test troglitazone, pioglitazone, rosiglitazone, BRL 49653 and the anti-inflammatory NSAIDs, indomethacin and ibuprofen. Results from these studies will provide a direct link between the reportedly elevated expression levels of PPAR ..
  41. Nornicotine for Treatment of Pain
    JOSEPH HOLTMAN; Fiscal Year: 2007
    ..morphine) and the nonsteroidal antiinflammatory drugs (NSAID's; eg. ibuprofen, celecoxib)...
  42. RISK FACTORS FOR PULMONARY HYPERTENSION OF THE NEWBORN
    ALLEN MITCHELL; Fiscal Year: 2002
    ..smoking and antenatal exposure to non-steroidal anti-inflammatory drugs (NSAIDs), particularly aspirin or ibuprofen, may play a role in the etiology of this condition. Because these exposures are quite prevalent (e.g...
  43. GI safety and therapeutics of oil-based PC-NSAIDs
    Lenard Lichtenberger; Fiscal Year: 2002
    ..are focused on confirming preliminary data that the oil-based PC-NSAIDs (and specifically PC-aspirin and PC-ibuprofen) possess low GI toxicity and enhanced therapeutic activity employing rodent models of acute and chronic NSAID-..
  44. Integrated Neuroimaging and Pathology of Alzheimer Mice
    Alpaslan Dedeoglu; Fiscal Year: 2006
    ..Although, ibuprofen lowers A Beta 1-42 / A Beta 1-40 ratio in mouse brain it is not known if it alter the process of ..
  45. EFFECT OF REPERFUSION ON POST-MI ANEURYSM FORMATION
    CAROLYN CONNELLY; Fiscal Year: 1991
    ..Following these studies, two interventions: 1) Ibuprofen, an anti-inflammatory agent known to reduce infarct size, and 2) Vitamin C, a co-factor in collagen formation ..
  46. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..Much of the available literature does not address these issues. Preliminary work indicates that ibuprofen administered in the drinking water promotes behavioral recuperation in mice that have undergone abdominal ..
  47. PREDOCTORAL FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    JONATHAN ALBERDING; Fiscal Year: 2003
    ..B) Or use indomethacin and/or ibuprofen to see if the distension is dependent on release of vasodilators PGI2/PGE2 from smooth muscle cells and/or ..
  48. MENTAL DISORDERS OF AGING--ANTIINFLAMMATION IN AD
    Gary Small; Fiscal Year: 2003
    ..The proposed project is designed to determine if the commonly used non-steroidal anti-inflammatory drug (NSAID), ibuprofen, is efficacious in delaying progression of cognitive symptoms in people with age-related cognitive losses who ..
  49. A GENE BASED THERAPEUTIC FOR ACUTE LUNG INJURY
    Kenneth Brigham; Fiscal Year: 1999
    ..formulations on systemic hemodynamics, lung mechanics and gas exchange with and without pretreatment with ibuprofen; 2) determine the effects of transfection of the lungs with the AAT gene on endotoxin induced alterations in ..
  50. TRAUMA: REGULATORS AND MODULATORS OF THE CATABOLIC STATE
    Douglas Wilmore; Fiscal Year: 1993
    ..which are known to enhance immunologic function such as growth hormone and interleukin-2 (IL-2) combined with ibuprofen will be administered in trauma patients in controlled trials...
  51. PHARMACOGENETIC DETERMINANTS OF HUMAN BIRTH DEFECTS
    ALLEN MITCHELL; Fiscal Year: 2004
    ..newborn, following exposure late in pregnancy to nonsteroidal anti-inflammatory drugs (NSAIDs), and particularly ibuprofen, a drug that is among the most commonly used agents in pregnancy...
  52. ApoJ (Clusterin) in Alzheimer's Disease and Aging
    Caleb Finch; Fiscal Year: 2006
    ..We will manipulate aging and AD-like changes in APP transgenics with caloric restriction and ibuprofen. We also predict that apoJ-deficiency will attenuate microglial activation during normal aging...
  53. A screen for small molecule inhibitors of soluble Abeta oligomer assembly
    Harry LeVine; Fiscal Year: 2007
    ..Anti-oligomer compounds could potentially block the cognitive impairment symptoms that oligomers elicit in animal models and interfere with the progression of Alzheimer's disease. [unreadable] [unreadable] [unreadable]..
  54. In Vitro Cancer Prevention Biomarker Development
    Eugene Elmore; Fiscal Year: 2004
    ..Using cluster analysis, we will determine the global gene expression changes induced by each agent. The strength of the proposed approach lies in the high quality data that has already determined from the HEC Assay. ..
  55. Vessel Remodeling During Ductus Arteriosus Closure
    Ronald I Clyman; Fiscal Year: 2010
    ..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..
  56. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2003
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  57. Novel Imaging to Predict Cardiovascular Events in Diabetes
    Zahi A Fayad; Fiscal Year: 2010
    ..It is our expectation that our data will be utilized to evaluate and improve existent treatment and develop effective new therapies to decrease the burden of atherosclerotic disease in diabetes. ..
  58. Epigallocatechin gallate, Prostate cancer & Angiogenesis
    Myoung Kim; Fiscal Year: 2004
    ..abstract_text> ..
  59. ADAPTATION OF SENESCENT MUSCLE TO EXERCISE TRAINING
    Todd Trappe; Fiscal Year: 2002
    ....