phenylacetates

Summary

Top Publications

  1. pmc Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road N W, Washington, DC 20057, USA
    Glia 57:550-60. 2009
  2. pmc Bacterial phenylalanine and phenylacetate catabolic pathway revealed
    R Teufel
    Department of Mikrobiologie, Fakultat fur Biologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 107:14390-5. 2010
  3. ncbi Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence
    Z Chen
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 164:4522-32. 2000
  4. ncbi Population pharmacokinetic analysis of blood and joint synovial fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis
    Hanna E Silber
    Novartis Pharma AG, Modeling and Simulation Pharmacology, Postfach, Basel, Switzerland
    Pharm Res 27:2633-45. 2010
  5. pmc Azospirillum brasilense produces the auxin-like phenylacetic acid by using the key enzyme for indole-3-acetic acid biosynthesis
    E Somers
    Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Belgium
    Appl Environ Microbiol 71:1803-10. 2005
  6. pmc Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production
    Diana M Harris
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    BMC Genomics 10:75. 2009
  7. ncbi TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo
    B B Cazac
    Department of Medicine, The Windeyer Institute of Medical Sciences, University College, London, United Kingdom
    Immunity 13:443-51. 2000
  8. ncbi Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice
    M Matsumoto
    Center for Immunology and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 382:462-6. 1996
  9. ncbi MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor
    Vilen A Movsesyan
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    J Neurochem 89:1528-36. 2004
  10. ncbi Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo
    C Angelin-Duclos
    Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 165:5462-71. 2000

Research Grants

  1. PHENYLACETATE--NOVEL THERAPEUTIC USES IN BREAST CANCER
    Neil Sidell; Fiscal Year: 2005
  2. Light activated bioactive substrate release
    RICHARD GIVENS; Fiscal Year: 2008
  3. DOES PKU PROTECT AGAINST CANCER?
    Neil Sidell; Fiscal Year: 2003
  4. Structure/Function of Peroxisomes in Neuroinflammation
    Inderjit Singh; Fiscal Year: 2008
  5. The influence of age on CD4 helper activity
    Laura Haynes; Fiscal Year: 2006
  6. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
  7. Mechanism of Actions of Multitasking of Statins in AD
    Inderjit Singh; Fiscal Year: 2006
  8. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
  9. A Study of NSAIDS on Neuronal Ion Channels
    ROBERT HALLIWELL; Fiscal Year: 2006
  10. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007

Detail Information

Publications191 found, 100 shown here

  1. pmc Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road N W, Washington, DC 20057, USA
    Glia 57:550-60. 2009
    ..These data indicate that microglial mGluR5 may represent a novel target for modulating neuroinflammation, an important component of both acute and chronic neurodegenerative disorders...
  2. pmc Bacterial phenylalanine and phenylacetate catabolic pathway revealed
    R Teufel
    Department of Mikrobiologie, Fakultat fur Biologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 107:14390-5. 2010
    ..It provides insight into the natural remediation of man-made environmental contaminants such as styrene. Furthermore, this pathway occurs in various pathogens, where its reactive early intermediates may contribute to virulence...
  3. ncbi Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence
    Z Chen
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 164:4522-32. 2000
    ..These observations suggest that B cell activation/survival signals mediated by CD21 and/or the retention of Ag by CD21/CD35 play important roles in the generation, quality, and maintenance of serum Ab...
  4. ncbi Population pharmacokinetic analysis of blood and joint synovial fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis
    Hanna E Silber
    Novartis Pharma AG, Modeling and Simulation Pharmacology, Postfach, Basel, Switzerland
    Pharm Res 27:2633-45. 2010
    ..The purpose of this population analysis was to characterize the pharmacokinetic properties of robenacoxib in blood and stifle joint synovial fluid of dogs...
  5. pmc Azospirillum brasilense produces the auxin-like phenylacetic acid by using the key enzyme for indole-3-acetic acid biosynthesis
    E Somers
    Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Belgium
    Appl Environ Microbiol 71:1803-10. 2005
    ..The synthesis of PAA by A. brasilense is discussed in relation to previously reported biocontrol properties of A. brasilense...
  6. pmc Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production
    Diana M Harris
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    BMC Genomics 10:75. 2009
    ..The recent sequencing of Penicillium chrysogenum strain Wisconsin1255-54 and the availability of genomics tools such as DNA-microarray offer new perspective...
  7. ncbi TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo
    B B Cazac
    Department of Medicine, The Windeyer Institute of Medical Sciences, University College, London, United Kingdom
    Immunity 13:443-51. 2000
    ..The data reveal differential roles of TbetaR in homeostasis and antigen responsiveness of B cell subpopulations and establish a critical function of the TGF-beta receptor ligand pair in the induction of IgA responses in vivo...
  8. ncbi Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice
    M Matsumoto
    Center for Immunology and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 382:462-6. 1996
    ..2 showed somatic mutations typical of affinity maturation. Thus, B-cell memory and affinity maturation are not absolutely dependent on the presence of germinal centres...
  9. ncbi MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor
    Vilen A Movsesyan
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    J Neurochem 89:1528-36. 2004
    ..Thus, mGluR5 activation limits the release of mitochondrial proteins associated with induction of both caspase-dependent and -independent apoptosis...
  10. ncbi Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo
    C Angelin-Duclos
    Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 165:5462-71. 2000
    ..Together, these data support a model in which B cell fate decisions occur within the germinal center and Blimp-1 expression is critical for commitment to a plasma cell, rather than a memory cell, fate...
  11. ncbi CprK crystal structures reveal mechanism for transcriptional control of halorespiration
    M Gordon Joyce
    Manchester Interdisciplinary Biocentre, P O Box 88, Manchester, M60 1QD, United Kingdom
    J Biol Chem 281:28318-25. 2006
    ..These structures provide a structural framework for further studies on transcriptional control by CRP-FNR homologs in general and of halorespiration regulation by CprK in particular...
  12. pmc The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
    K G Smith
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 16:2996-3006. 1997
    ..In contrast, the memory B-cell population contains few, if any, cells from the early response and is less stringently selected...
  13. pmc Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase
    David J Loane
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 284:15629-39. 2009
    ..These data suggest that mGluR5 represents a novel target for modulating microglial-dependent neuroinflammation, and may have therapeutic relevance for neurological disorders that exhibit microglial-mediated neurodegeneration...
  14. ncbi Memory B-cell persistence is independent of persisting immunizing antigen
    M Maruyama
    Institute for Genetics, University of Cologne, Germany
    Nature 407:636-42. 2000
    ....
  15. ncbi Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons
    Pamela J Voulalas
    Molecular Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 25:3763-73. 2005
    ..Thus, signal transduction pathways activated by DR1/5 and mGluR5 interact to modify downstream events in striatal neurons while retaining numerous regulatory checkpoints...
  16. ncbi Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities
    K N Gan
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109 0626
    Drug Metab Dispos 19:100-6. 1991
    ..Studies on the genetically determined polymorphism responsible for two allozymic forms (A and B) of the esterase are described in the following paper...
  17. ncbi Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia
    W L Bao
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Research Building, Rm. EP12, 20007, Washington, DC 20007, USA
    Brain Res 922:173-9. 2001
    ..Therefore, both types of compounds may prove to have therapeutic potential for the treatment of stroke...
  18. ncbi PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity
    Clement E Furlong
    Department of Genome Sciences, Division of Medical Genetics, University of Washington, Seattle, Washington 98195 7720, USA
    Pharmacogenet Genomics 16:183-90. 2006
    ..Of particular concern are exposures of pregnant mothers and newborns with low PON1 status...
  19. ncbi Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli
    A Ferrandez
    Department of Molecular Microbiology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28006 Madrid, Spain
    J Biol Chem 275:12214-22. 2000
    ..These global regulators may adjust the transcriptional output from Pa and Pz promoters to the overall growth status of the cell...
  20. ncbi Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac
    Richard Lindstrom
    Minnesota Eye Consultants, Minneapolis, MN 55904, USA
    Curr Med Res Opin 22:397-404. 2006
    ..Preclinical data suggest nepafenac may also provide unique efficacy in the posterior segment...
  21. ncbi Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction
    J M Mingot
    Departamento de Microbiologia Molecular, Centro de Investigaciones Biológicas del Consejo Superior de Investigaciones Científicas, Velazquez 144, Madrid, 28006, Spain
    J Biol Chem 274:14545-50. 1999
    ....
  22. pmc Genetic and functional analysis of the styrene catabolic cluster of Pseudomonas sp. strain Y2
    A Velasco
    Department of Molecular Microbiology, Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
    J Bacteriol 180:1063-71. 1998
    ..These results strongly suggest that the genes responsible for the complete mineralization of styrene are clustered in the chromosome of Pseudomonas sp. strain Y2...
  23. pmc Novel phacB-encoded cytochrome P450 monooxygenase from Aspergillus nidulans with 3-hydroxyphenylacetate 6-hydroxylase and 3,4-dihydroxyphenylacetate 6-hydroxylase activities
    Francisco Ferrer-Sevillano
    Instituto de Biologia Molecular, Genómica y Proteómica, Universidad de Leon, Campus de Vegazana, s n 24071 León, Spain
    Eukaryot Cell 6:514-20. 2007
    ..This cytochrome P450 protein also uses PhAc as a substrate to generate 2-OH-PhAc with a very low efficiency. The phacB gene is the first member of a new CYP450 subfamily (CYP504B)...
  24. ncbi Induction and repression of the sty operon in Pseudomonas putida CA-3 during growth on phenylacetic acid under organic and inorganic nutrient-limiting continuous culture conditions
    Niall D O'Leary
    Microbiology Department, National University of Ireland, Cork, Ireland
    FEMS Microbiol Lett 208:263-8. 2002
    ..putida CA-3, during growth on phenylacetic acid under continuous culture conditions, involves regulatory mechanisms coordinately affecting both the upper and lower pathways and acting at the level of gene transcription...
  25. pmc Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains
    M Rodriguez-Saiz
    Laboratorio de Biotecnologia, Antibióticos S A, 24009 León, Spain
    J Bacteriol 183:5465-71. 2001
    ..The mutation has been tracked down to Wisconsin 49-133, a mutant obtained at the Department of Botany of the University of Wisconsin in 1949, at the beginning of the development of the Wisconsin family of strains...
  26. pmc Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    Ann Neurol 66:63-74. 2009
    ..Previously, mGluR5 has been identified on microglia in vitro, but the effects of mGluR5 activation on inflammation in vivo or on recovery after spinal cord injury is unknown...
  27. ncbi Influence of peptide supply and cosubstrates on phenylalanine metabolism of Lactobacillus sanfranciscensis DSM20451(T) and Lactobacillus plantarum TMW1.468
    Nicoline Vermeulen
    Technische Mikrobiologie, Technische Universitat Munchen, Weihenstephaner Steig 16, D 85350 Freising, Germany
    J Agric Food Chem 54:3832-9. 2006
    ..In L. sanfranciscensis DSM20451, a combination of both citric acid and alpha-ketoglutarate increased PLA formation. The combined effect of citric acid and alpha-ketoglutarate can be attributed to changes in the NAD/NADH ratio...
  28. ncbi Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region
    A L Bothwell
    Cell 24:625-37. 1981
    ..Certain of the sequenced VH genes contain crippling mutations; the repertoire of germ line VH genes that can contribute to the diversity of antibodies may therefore be less than the total number of genes detectable by hydridization...
  29. ncbi Styrene lower catabolic pathway in Pseudomonas fluorescens ST: identification and characterization of genes for phenylacetic acid degradation
    Patrizia Di Gennaro
    Department of Environmental Sciences, University of Milano Bicocca, Piazza della Scienza 1, 20126, Milan, Italy
    Arch Microbiol 188:117-25. 2007
    ..The function of some of the isolated genes has been proved by means of biotransformation experiments...
  30. ncbi Characterization of a second functional gene cluster for the catabolism of phenylacetic acid in Pseudomonas sp. strain Y2
    David Bartolomé-Martín
    Departmento de Bioquimica y Biologia Molecular, I, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Ciudad Universitaria, s n 28040 Madrid, Spain
    Gene 341:167-79. 2004
    ..The co-existence of two functional gene clusters for the degradation of phenylacetic acid in a bacterium has not been reported so far...
  31. ncbi Aerobic metabolism of phenylacetic acids in Azoarcus evansii
    Magdy el Said Mohamed
    Mikrobiologie, Institut fur Biologie II, Schanzlestrasse 1, Universitat Freiburg, 79104 Freiburg, Germany
    Arch Microbiol 178:180-92. 2002
    ..evansiigrowing aerobically with PA showed a probable organization of the paa genes in three operons. The similarity of the PA metabolic products pattern and of gene sequences suggests a common aerobic bacterial PA pathway...
  32. ncbi Transcriptional regulation of styrene degradation in Pseudomonas putida CA-3
    W Duetz
    Microbiology Department, National University of Ireland, Cork, Ireland
    Microbiology 147:973-9. 2001
    ..putida CA-3 was grown on styrene together with an additional carbon source and it is reported that catabolite repression may involve a different mechanism to transcriptional repression by an additional carbon source...
  33. pmc In vitro and in vivo effects of easily administered, low-toxic retinoid and phenylacetate compounds on human neuroblastoma cells
    N Sidell
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Br J Cancer 89:412-9. 2003
    ..Taken together, these findings demonstrate the possibility that RAG and/or 4-CPA may serve as effective, less-toxic alternatives to 13-cis RA, which is presently being utilised for nb therapy...
  34. ncbi Regulation of penicillin G acylase gene expression in Escherichia coli by repressor PaaX and the cAMP-cAMP receptor protein complex
    Hyoung Seok Kim
    Department of Microbiology, School of Biological Sciences, Seoul National University, San 56 1, Shillim Dong, Kwanak gu, 151 742, Korea
    J Biol Chem 279:33253-62. 2004
    ..This implies that PaaX and the cAMP-CRP compete for binding to the region around the CRP-binding site I and therefore have antagonistic effects on pga expression...
  35. ncbi Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli
    Wael Ismail
    Mikrobiologie, Institut fur Biologie II, Universitat Freiburg, Germany
    Eur J Biochem 270:3047-54. 2003
    ..The subsequent beta-oxidation-type degradation of the resulting CoA dicarboxylate via beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA appears to be catalyzed by the PaaJ, PaaF and PaaH proteins...
  36. ncbi A two-component hydroxylase involved in the assimilation of 3-hydroxyphenyl acetate in Pseudomonas putida
    Elsa Arias-Barrau
    Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinaria, Universidad de Leon, 24007 Leon, Spain
    J Biol Chem 280:26435-47. 2005
    ....
  37. pmc Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase
    Mónica Lamas-Maceiras
    Area de Microbiologia, Facultad de Ciencias Biologicas y Ambientales, Universidad de Leon, Campus de Vegazana, S N, 24071 Leon, Spain
    Biochem J 395:147-55. 2006
    ..The peroxisomal co-localization of these two proteins indicates that the last two enzymes of the penicillin pathway form a peroxisomal functional complex...
  38. ncbi Modulation by phenylacetate of early estrogen-mediated events in MCF-7 breast cancer cells
    Jingbo Liu
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Chemother Pharmacol 59:217-25. 2007
    ..We now shed additional light on the antiestrogenic action of PA by determining its effects on early events in the estrogen-signaling pathway...
  39. ncbi Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway
    A Ferrandez
    Department of Molecular Microbiology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28006 Madrid, Spain
    J Biol Chem 273:25974-86. 1998
    ..The aerobic catabolism of PA in E. coli represents a novel hybrid pathway that could be a widespread way of PA catabolism in bacteria...
  40. ncbi A quasi-monoclonal mouse
    M Cascalho
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0670, USA
    Science 272:1649-52. 1996
    ..Thus, neither network interactions nor random activation of a small fraction of the B cell population can account for serum Ig concentrations...
  41. ncbi Uptake of phenylacetic acid by two strains of Penicillium chrysogenum
    S H Eriksen
    Department of General Microbiology, Institute of Molecular Biology, University of Copenhagen, Solvgade 83H, DK 1307 K, Copenhagen, Denmark
    Biotechnol Bioeng 60:310-6. 1998
    ..chrysogenum Wisconsin 54-1255. At high concentrations of phenylacetic acid, contribution to uptake by this carrier is minor in comparison to simple diffusion and therefore, of no importance in the industrial production of penicillin...
  42. pmc Inhibition of estrogen-induced mammary tumor formation in MMTV-aromatase transgenic mice by 4-chlorophenylacetate
    Neil Sidell
    Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA
    Cancer Lett 251:302-10. 2007
    ..The data suggest that 4-CPA is a novel therapeutic agent that could be used in the prevention or treatment of estrogen-sensitive breast cancer...
  43. pmc Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells
    L G Hannum
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Exp Med 192:931-42. 2000
    ..Moreover, as indicated by the presence and pattern of somatic mutations, memory cell formation and selection appear normal in these IC-deficient GCs...
  44. pmc In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
    J Jacob
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201
    J Exp Med 178:1293-307. 1993
    ..Together, these observations demonstrate that the germinal center microenvironment is rich and temporally complex but may not be constitutive for somatic hypermutation...
  45. ncbi The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection
    A Ridderstad
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 157:3357-65. 1996
    ..Therefore, our results imply that the reduced memory B cell frequency in xid mice is still above some threshold value necessary for a normal secondary immune response...
  46. ncbi Genetic analysis of phenylacetic acid catabolism in Arthrobacter oxydans CECT386
    Juana María Navarro-Llorens
    Departamento de Bioquimica y Biologia Molecular I, Universidad Complutense de Madrid, Ciudad Universitaria, S N, 28040, Madrid, Spain
    Arch Microbiol 190:89-100. 2008
    ..The results of this study broaden the knowledge regarding the range of metabolic potential of this strain and eventually make it attractive for environmental applications...
  47. ncbi Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients
    Fernando Scaglia
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm 635E, Houston, TX 77030, USA
    Mol Genet Metab 81:S79-85. 2004
    ..These findings suggest that better titration of protein restriction could be achieved with branched chain amino acid supplementation in patients with UCDs who are on alternative route therapy...
  48. ncbi Genetic characterization of the styrene lower catabolic pathway of Pseudomonas sp. strain Y2
    Sergio Alonso
    Department of Biochemistry and Molecular Biology, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Ciudad Universitaria, 28040, Madrid, Spain
    Gene 319:71-83. 2003
    ..Although the upper and lower styrene catabolic clusters are adjacent in the Pseudomonas sp. strain Y2 chromosome, their particular base composition and codon usage suggest a distinct evolutionary history...
  49. ncbi Cytosporone B is an agonist for nuclear orphan receptor Nur77
    Yanyan Zhan
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China
    Nat Chem Biol 4:548-56. 2008
    ..Thus, Csn-B may represent a promising therapeutic drug for cancers and hypoglycemia, and it may also be useful as a reagent to increase understanding of Nur77 biological function...
  50. ncbi Why did the Fleming strain fail in penicillin industry?
    Marta Rodríguez-Sáiz
    R and D Biology, Antibióticos S A, Avenida de Antibióticos 59 61, E 24009 León, Spain
    Fungal Genet Biol 42:464-70. 2005
    ..Our data thus show that a loss of function in P. chrysogenum PahA is directly related to penicillin overproduction, and support the historic choice of P. chrysogenum as the industrial producer of penicillin...
  51. pmc Accumulation of polyhydroxyalkanoate from styrene and phenylacetic acid by Pseudomonas putida CA-3
    Patrick G Ward
    Department of Industrial Microbiology, Centre for Synthesis and Chemical Biology, Conway Institute for Biomolecular and Biomedical Research, National University of Ireland, University College Dublin, Belfield, Dublin 4, Republic of Ireland
    Appl Environ Microbiol 71:2046-52. 2005
    ..The maximum yields for PHA from styrene, phenylacetic acid, and glucose are 0.11, 0.17, and 0.22 g of PHA per g of carbon, respectively...
  52. pmc A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model
    Robyn J Law
    Department of Microbiology, Buller Building, Room 418, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    J Bacteriol 190:7209-18. 2008
    ..elegans. Taken together, our results demonstrate that B. cenocepacia possesses a functional PA degradation pathway and that the putative PA-CoA ring hydroxylation system is required for full pathogenicity in C. elegans...
  53. pmc Genetic characterization of accumulation of polyhydroxyalkanoate from styrene in Pseudomonas putida CA-3
    Niall D O'Leary
    Microbiology Department, National University of Ireland, Cork, Ireland
    Appl Environ Microbiol 71:4380-7. 2005
    ..putida CA-3. Cloning and functional characterization of the pha locus, responsible for PHA polymerization/depolymerization is also reported and the significance and future prospects of this novel bioconversion are discussed...
  54. pmc Genetic characterization of the phenylacetyl-coenzyme A oxygenase from the aerobic phenylacetic acid degradation pathway of Escherichia coli
    Cristina Fernandez
    Department of Molecular Microbiology, Centro de Invetigaciones Biológicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Appl Environ Microbiol 72:7422-6. 2006
    ..The primary structure of the subunits of bacterial phenylacetyl-CoA oxygenases revealed that these enzymes constitute the prototype of a new and distinct group of the large bacterial diiron multicomponent oxygenase family...
  55. pmc The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida
    Elsa Arias-Barrau
    Estación Agrícola Experimental, Consejo Superior de Investigaciones Cientificas, Finca Marzanas, 24346 Grulleros, Leon, Spain
    J Bacteriol 186:5062-77. 2004
    ..putida U funnels also into the homogentisate central pathway, revealing that the hmg cluster is a key catabolic trait for biodegradation of a small number of aromatic compounds...
  56. pmc Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster
    M A Prieto
    Department of Molecular Microbiology, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Bacteriol 178:111-20. 1996
    ....
  57. ncbi Novel auxin transport inhibitors phenocopy the auxin influx carrier mutation aux1
    G Parry
    Division of Plant Sciences, School of Biosciences, University of Nottingham, Nottingham NG7 2RD, UK
    Plant J 25:399-406. 2001
    ..Whilst results indicate that 1-NOA and CHPAA represent useful tools for physiological studies addressing the role of auxin influx in planta, 1-NOA is likely to prove the more useful of the two compounds...
  58. ncbi Effect of phenylacetic acid feeding on the process of cellular autolysis in submerged batch cultures of Penicillium chrysogenum
    S White
    Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Scotland, UK
    J Biotechnol 75:173-85. 1999
    ..chrysogenum. By contrast, exploitation of the toxicity of PAA is proposed as a means to bring forward or enhance autolysis, providing a reliable method of 'induction' with which to study the phenomenon in P. chrysogenum...
  59. pmc Molecular characterization of the phenylacetic acid catabolic pathway in Pseudomonas putida U: the phenylacetyl-CoA catabolon
    E R Olivera
    Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinaria, Universidad de Leon, 24007 Leon, Spain
    Proc Natl Acad Sci U S A 95:6419-24. 1998
    ..This pathway constitutes the common part (core) of a complex functional unit (catabolon) integrated by several routes that catalyze the transformation of structurally related molecules into a common intermediate (phenylacetyl-CoA)...
  60. ncbi Microbial metabolism of quinoline and related compounds. VI. Degradation of quinaldine by Arthrobacter sp
    H K Hund
    Institut fur Mikrobiologie, Universitat Hohenheim
    Biol Chem Hoppe Seyler 371:1005-8. 1990
    ..3-Hydroxy-N-acetylanthranilic acid was not further metabolized by this organism. A degradation pathway is proposed...
  61. pmc Aponecrotic, antiangiogenic and antiproliferative effects of a novel dextran derivative on breast cancer growth in vitro and in vivo
    Mélanie Di Benedetto
    Laboratoire de Ciblage et Imagerie Fonctionnelle de la Progression Tumorale, UPRES 2360, Universite Paris 13, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
    Br J Pharmacol 135:1859-71. 2002
    ..6. NaPaC acts like NaPa and CMDB but in more potent manner than components used separately. Its antiproliferative, aponecrotic and anti-angiogenic actions make it a good candidate for a new anti-cancer drug...
  62. ncbi Development and maintenance of a B220- memory B cell compartment
    D J Driver
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 167:1393-405. 2001
    ..The cellular dynamics and molecular attributes of these unique memory B cells suggest they are distinct cellular products of the germinal center reaction in the primary response and are maintained long-term in the spleen and bone marrow...
  63. ncbi Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats: possible relevance to the effects of mGlu5R blockade in Parkinson's disease
    Maria Rosaria Domenici
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Neurosci Res 80:646-54. 2005
    ..While chronic MPEP did not potentiate L-DOPA-induced turning in a classical model of PD, its ability to reduce mGlu5R-associated signal could help to explain the neuroprotective/antiparkinsonian effects observed in other models of PD...
  64. pmc Interaction of group I mGlu and NMDA receptor agonists within the dorsal horn of the spinal cord of the juvenile rat
    K Dang
    Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK
    Br J Pharmacol 136:248-54. 2002
    ..In the presence of a GABA(B) receptor antagonist, the direct synergistic interaction is unmasked. These data suggest that group I mGlu receptors provide a complex modulation of spinal synaptic processes...
  65. pmc Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors
    Paul M Lea
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057 2197, USA
    Br J Pharmacol 145:527-34. 2005
    ..5 Combined, these studies support the conclusion that MTEP has greater mGluR5 selectivity than MPEP, and that neuroprotection provided by either antagonist in neuronal cultures does not reflect inhibition of mGluR5 receptors...
  66. ncbi Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons
    Limin Mao
    Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri 64108, USA
    J Biol Chem 280:12602-10. 2005
    ..Together, we have identified a novel, mGluR5-triggered signaling mechanism involving use- and Src-dependent inactivation of PP2A, which contributes to mGluR5 activation of MEK1/2 and ERK1/2...
  67. ncbi An ionotropic but not a metabotropic glutamate agonist potentiates the pharmacological effects of olanzapine in the rat
    Rossella Dall'olio
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Behav Pharmacol 16:635-42. 2005
    ....
  68. ncbi Group I metabotropic glutamate receptors modulate glutamate and gamma-aminobutyric acid release in the periaqueductal grey of rats
    Vito De Novellis
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine and Surgery, Second University of Naples, Via Costantinopoli, 16 80138 Naples, Italy
    Eur J Pharmacol 462:73-81. 2003
    ..In particular, mglu(5), but not mglu(1), receptors seem to be functionally active on glutamate terminals...
  69. pmc Regulation of kainate receptors by protein kinase C and metabotropic glutamate receptors
    Kwangwook Cho
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 548:723-30. 2003
    ....
  70. ncbi Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents
    Gene G Kinney
    Department of Neuroscience, Merck, West Point, PA 19486, USA
    J Pharmacol Exp Ther 306:116-23. 2003
    ....
  71. ncbi Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects
    M T Tebano
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Neurochem 95:1188-200. 2005
    ..This is the first evidence showing that hippocampal A(2A)Rs and mGlu5Rs are co-located and act synergistically, and that A(2A)Rs play a permissive role in mGlu5R receptor-mediated potentiation of NMDA effects in the hippocampus...
  72. ncbi Effect of the group I metabotropic glutamate agonist DHPG on the visual cortex
    X T Jin
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurophysiol 86:1622-31. 2001
    ..Thus there are multiple effects of group I metabotropic glutamate receptors, which vary with layer and age in visual cortex...
  73. ncbi Preproenkephalin mRNA expression in rat dorsal striatum induced by selective activation of metabotropic glutamate receptor subtype-5
    Nikhil K Parelkar
    Division of Pharmacology, University of Missouri Kansas City, School of Pharmacy, Kansas City, Missouri 64108, USA
    Synapse 47:255-61. 2003
    ..Moreover, activation of mGluR5 participates in the mediation of D(2) antagonist-induced PPE expression...
  74. ncbi Activation of metabotropic glutamate receptor 5 is associated with effect of amphetamine on brain neurons
    Meng Fen Yu
    Chang Gang Institute of Technology, School of Nursing, Tao Yuan, Taiwan, ROC
    Synapse 50:334-44. 2003
    ..The AMPH-induced altered activity of mGluR5 is probably associated with changes in the expression of the glutamate receptors, including mGluR5. AMPH may modify the sensitivity of mGluR5 or interact with the receptor itself...
  75. ncbi Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat
    Tao Xu
    Department of Anesthesiology, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
    Neurosci Lett 420:155-9. 2007
    ..We conclude that mGluR5 contributes to the development of tolerance to morphine-induced antinociception after chronic morphine exposure...
  76. ncbi Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum
    M R Domenici
    J Neurochem 90:1276-9. 2004
    ..The results indicate that A2ARs exert a permissive role on mGlu5R-induced effects in the striatum. Such an interaction may represent an additional target for the development of therapeutic strategies towards striatal disorders...
  77. ncbi NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity
    M Pizzi
    Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, 25123 Brescia, Italy
    Cell Death Differ 12:761-72. 2005
    ..These data demonstrate that mGlu5 receptor activation promotes a c-Rel-dependent antiapoptotic pathway responsible for neuroprotection against Abeta peptide...
  78. ncbi Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    A Pisani
    Clinica Neurologica, Dipartmento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 106:579-87. 2001
    ....
  79. ncbi Vialinin B, a novel potent inhibitor of TNF-alpha production, isolated from an edible mushroom, Thelephora vialis
    Chun Xie
    Department of Nutritional Science, Faculty of Applied Bio Science, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Bioorg Med Chem Lett 16:5424-6. 2006
    ..02nM) and is a promising anti-allergic agent...
  80. ncbi Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity
    Guo Q Shi
    Departments of Medicinal Chemistry, Merck Research Laboratories, P O Box 2000, Rahway, New Jersey 07065 0900, USA
    J Med Chem 48:4457-68. 2005
    ..They all showed excellent anti-hyperglycemic efficacy in a db/db mouse model and hypolipidemic activity in hamster and dog models without provoking the typical PPARgamma-associated side effects in the rat tolerability assay...
  81. ncbi Activation of mGluR5 modulates GABA(A) receptor function in retinal amacrine cells
    Brian K Hoffpauir
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Neurophysiol 88:1766-76. 2002
    ..These results support the possibility that glutamate released from bipolar cells can modulate the function of GABAergic amacrine cells and alter signaling in the inner plexiform layer...
  82. ncbi Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons
    Weidong Li
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurophysiol 91:13-24. 2004
    ..These data suggest a change of mGluR1 function and activation in the amygdala in pain-related sensitization, whereas mGluR5 is involved in brief as well as prolonged nociception...
  83. pmc Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei
    Silvarosa Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Perugia I 06100, Italy
    J Physiol 543:795-806. 2002
    ..An additional inhibitory control is exerted by mGluR5 at the level of this facilitatory phase...
  84. ncbi Role of group II metabotropic glutamate receptors 2/3 and group I metabotropic glutamate receptor 5 in developing rat medial vestibular nuclei
    Silvarosa Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, I 06100 Perugia, Italy
    Neuroreport 16:1303-7. 2005
    ....
  85. ncbi Developmental switch from LTD to LTP in low frequency-induced plasticity
    Fabien Lanté
    Laboratory Oxidative Stress and Neuroprotection, University Montpellier II, Montpellier, Cedex, France
    Hippocampus 16:981-9. 2006
    ..Low-frequency-mediated synaptic plasticity is subject to a developmental switch from NMDA- and mGlu5 receptor-dependent LTD to mGlu5 receptor-dependent LTP with a transient period (17-21 day-old) during which LFS is ineffective...
  86. ncbi Inhibition of MPEP on the development of morphine antinociceptive tolerance and the biosynthesis of neuronal nitric oxide synthase in rat spinal cord
    Tao Xu
    Department of Anesthesiology, The Sixth Affiliated People s Hospital, Shanghai Jiaotong University, 600 Yi Shan Road, Shanghai 200233, China
    Neurosci Lett 436:214-8. 2008
    ..The synergistic effect which seems to exist between mGluRs and iGluRs may also contribute to this phenomenon...
  87. ncbi No improvement of functional and histological outcome after application of the metabotropic glutamate receptor 5 agonist CHPG in a model of endothelin-1-induced focal ischemia in rats
    M Riek-Burchardt
    Research Institute for Applied Neurosciences FAN gGmbH, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Neurosci Res 57:499-503. 2007
    ..In conclusion, our data point to the restricted value of CHPG as a neuroprotectant after transient focal ischemia and to the importance of evaluating neuroprotective effects at late post-ischemic time points...
  88. ncbi Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
    Timothy S Kern
    Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Diabetes 56:373-9. 2007
    ..Local inhibition of inflammatory pathways in the eye offers a novel therapeutic approach toward inhibiting the development of lesions of diabetic retinopathy...
  89. ncbi Kinetics of enzyme acylation and deacylation in the penicillin acylase-catalyzed synthesis of beta-lactam antibiotics
    Wynand B L Alkema
    Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands
    Eur J Biochem 270:3675-83. 2003
    ..By combining the results of the steady-state, presteady state and nucleophile binding experiments, values for the relevant kinetic constants for the synthesis and hydrolysis of beta-lactam antibiotics were obtained...
  90. ncbi Ketorolac tromethamine LS 0.4% versus nepafenac 0.1% in patients having cataract surgery. Prospective randomized double-masked clinical trial
    Hon Vu Q Duong
    Nevada State College, Henderson, Nevada 89012, USA
    J Cataract Refract Surg 33:1925-9. 2007
    ..To compare the clinical, subjective, and objective outcomes of the use of 2 topical nonsteroidal antiinflammatory drugs--ketorolac tromethamine LS 0.4% (Acular) and nepafenac 0.1% (Nevanac)--in patients having cataract surgery...
  91. ncbi In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac
    Tom Walters
    Keystone Research, Department of Ophthalmology, 1020 West 34th Street, Austin, Texas 78705, USA
    J Cataract Refract Surg 33:1539-45. 2007
    ..1%), Acular LS (ketorolac 0.4%), or Xibrom (bromfenac 0.09%)...
  92. ncbi Effects of nonsteroidal ophthalmic drops on epithelial healing and pain in patients undergoing bilateral photorefractive keratectomy (PRK)
    Daniel S Durrie
    Durrie Vision, Overland Park, Kansas 66211, USA
    Adv Ther 24:1278-85. 2007
    ..Pain relief with nepafenac 0.1% was achieved sooner than with ketorolac 0.4% or bromfenac 0.09%...
  93. ncbi Double-masked comparison of ketorolac tromethamine 0.4% versus nepafenac sodium 0.1% for postoperative healing rates and pain control in eyes undergoing surface ablation
    William Trattler
    Center for Excellence in Eye Care, Miami, FL 33176, USA
    Cornea 26:665-9. 2007
    ..4% (Acular LS) or nepafenac sodium 0.1% (Nevanac) after flapless surface ablation [epi-laser in situ keratomileusis (LASIK)]...
  94. ncbi Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery
    Stephen S Lane
    J Cataract Refract Surg 33:53-8. 2007
    ..To determine whether nepafenac ophthalmic suspension 0.1% decreases the incidence and severity of inflammation and pain after cataract surgery with posterior chamber intraocular lens implantation...
  95. ncbi Incidence of visually significant pseudophakic macular edema after uneventful phacoemulsification in patients treated with nepafenac
    Eric J Wolf
    Edward S Harkness Eye Institute, Columbia University College of Physicians and Surgeons, Department of Ophthalmology, 635 West 165th Street, New York, New York 10032, USA
    J Cataract Refract Surg 33:1546-9. 2007
    ..1% suspension (Nevanac)...
  96. doi Double-masked comparison of ketorolac tromethamine 0.4% versus nepafenac sodium 0.1% for postoperative healing rates and pain control in eyes undergoing surface ablation
    Richard Lindstrom
    Cornea 27:385-6; author reply 386-7. 2008
  97. ncbi New drugs: ramelteon, tipranavir, nepafenac, and deferasirox
    Daniel A Hussar
    Philadelphia College of Pharmacy, University of the Sciences, PA, USA
    J Am Pharm Assoc (2003) 46:107-11. 2006
  98. ncbi Comparative effects of the nonsteroidal anti-inflammatory drug nepafenac on corneal sensory nerve fibers responding to chemical irritation
    M Carmen Acosta
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, San Juan de Alicante, Spain
    Invest Ophthalmol Vis Sci 48:182-8. 2007
    ....
  99. doi Re: Pharmacokinetics and pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac
    Frank A Bucci
    J Cataract Refract Surg 34:1226; author reply 1226-7. 2008
  100. doi Ketorolac versus nepafenac in cataract surgery
    James P McCulley
    J Cataract Refract Surg 34:345-6; author reply 346. 2008
  101. ncbi Effects of topical nepafenac on corneal epithelial healing time and postoperative pain after PRK: a bilateral, prospective, randomized, masked trial
    Matthew Caldwell
    U S Air Force Warfighter Refractive Surgery Center, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, TX 78236 5300, USA
    J Refract Surg 24:377-82. 2008
    ..To assess the effects of nepafenac on corneal epithelial healing time and pain control compared to placebo in patients undergoing photorefractive keratectomy (PRK) surgery...

Research Grants38

  1. PHENYLACETATE--NOVEL THERAPEUTIC USES IN BREAST CANCER
    Neil Sidell; Fiscal Year: 2005
    ..Taken together, the information gained from these studies will provide a basic framework for the rationale use of PA analogs or similar acting compounds in the clinic. ..
  2. Light activated bioactive substrate release
    RICHARD GIVENS; Fiscal Year: 2008
    ..abstract_text> ..
  3. DOES PKU PROTECT AGAINST CANCER?
    Neil Sidell; Fiscal Year: 2003
    ....
  4. Structure/Function of Peroxisomes in Neuroinflammation
    Inderjit Singh; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  5. The influence of age on CD4 helper activity
    Laura Haynes; Fiscal Year: 2006
    ..abstract_text> ..
  6. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  7. Mechanism of Actions of Multitasking of Statins in AD
    Inderjit Singh; Fiscal Year: 2006
    ..abstract_text> ..
  8. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
  9. A Study of NSAIDS on Neuronal Ion Channels
    ROBERT HALLIWELL; Fiscal Year: 2006
    ..These data may also provide new drug leads and/or novel molecular targets for the treatment of pain and/or neurodegenerative diseases such as Alzheimer's type dementias. ..
  10. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. MR Imaging of Endothelial Progenitor Cells in Prostate Cancer
    Dmitri Artemov; Fiscal Year: 2007
    ..We will also follow the effect of different forms of antiangiogenic therapy on the process of progenitor cell recruitment and incorporation to the tumor vasculature. [unreadable] [unreadable] [unreadable]..
  12. Chemopreventive Activity of Selenium-Derivatives of Celecoxib in Melanoma
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2008
    ..Studies proposed here will be needed to adequately support the specific aims of a large grant application. [unreadable] [unreadable] [unreadable]..
  13. Discovery of Novel Pharmacotherapies: Cocaine Dependence
    PETER MELTZER; Fiscal Year: 2008
    ..vi) analogues of pyrovalerone. ..
  14. GENETIC & ENVIRONMENTAL DETERMINANTS OF CRANIOFACIAL DIS
    Brendan Lee; Fiscal Year: 2005
    ..Together, these studies will identify genes important in pathogenesis of human malformation and elucidate their modes of action in both cell autonomous and cell non-autonomous models mechanisms of development. ..
  15. Transcriptional Regulation of Craniofacial Skeletogenesis
    Brendan Lee; Fiscal Year: 2009
    ....
  16. Bioavailability of Tea Polyphenols in Prostate Cancer
    Susanne Henning; Fiscal Year: 2002
    ..ODC enzyme activity will be determined measuring the release of 14C CO2 from 14C ornithine. These studies will provide information important in designing studies to critically test the role of dietary supplementation in prostate cancer. ..
  17. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2011
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..
  18. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  19. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
  20. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2010
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  21. Aging and Immunity Workshop
    Laura Haynes; Fiscal Year: 2004
    ..In this proposal, we are specifically requesting funds to cover the basic costs to allow five junior investigators to attend the workshop, with the goal of fostering the next generation of immunologists in this field. ..
  22. Adenoviral hepatocyte gene therapy in Citrullinemia
    Brendan Lee; Fiscal Year: 2005
    ..The data from these studies would be widely applicable to gene replacement therapy in a host of intrinsic disorders of liver metabolism as well as deficiencies of secretory proteins. ..
  23. Dysregulation of 3-prolyl-hydroxylation in Human Skeletal Dysplasias
    BRENDAN HL LEE; Fiscal Year: 2010
    ..e., the in vivo phenotypic and biochemical consequences of dysregulation of the 3-prolyl-hydroxylation machinery. ..
  24. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2005
    ....
  25. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  26. MR Pharmacoangiography-Vascular Modulation of Delivery
    Dmitri Artemov; Fiscal Year: 2007
    ..All clinical studies involving patients will be performed in collaboration with Dr. Stuart Grossman. ..
  27. TRANSCRIPTIONAL REGULATORS IN CHONDROGENESIS
    Brendan Lee; Fiscal Year: 2002
    ....
  28. Metabolomic Signatures in ALS
    Merit Cudkowicz; Fiscal Year: 2005
    ..abstract_text> ..
  29. MR Pharmacoangiography-Vascular Modulation of Delivery
    Dmitri Artemov; Fiscal Year: 2005
    ..The experimental designs in this application will also, for the first time, evaluate the role of antivascular effects of a chemotherapeutic agent in tumor resistance using noninvasive and spatially informative techniques. ..
  30. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  31. Coenzyme Q10 in Huntington's Disease
    Merit Cudkowicz; Fiscal Year: 2007
    ..abstract_text> ..
  32. In vivo function and tolerance to Factor VIII variants
    BRENDAN HL LEE; Fiscal Year: 2011
    ..abstract_text> ..
  33. ENTERAL PRECURSORS FOR UREA SYNTHESIS IN HUMANS
    Brendan Lee; Fiscal Year: 2006
    ..In addition it is anticipated that the results will benef it other individuals who have compromised protein metabolism. ..
  34. DOUBLE BLIND STUDY OF MINOCYCLINE IN HD
    Merit Cudkowicz; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  35. Clinical Trial of Ceftriaxone in ALS
    Merit Cudkowicz; Fiscal Year: 2004
    ..Secondary outcome measures will include ALSFRS-R, vital capacity, strength, and the long-term safety and tolerability of ceftriaxone in this population. ..
  36. CLINICAL TRIAL OF TOPIRAMATE IN ALS
    Merit Cudkowicz; Fiscal Year: 2003
    ..Secondary outcome measures include grip strength, forced vital capacity, the ALS functional rating scale, and the safety and tolerability of topiramate in this population. ..
  37. RELEASE CHANNEL ISOFORMS AND LOCAL CALCIUM SIGNALING
    Natalia Shirokova; Fiscal Year: 2003
    ..Proposed studies will greatly advanced our knowledge of their functioning, which in turn could improve our understanding of their role in decease. ..
  38. NABTC Member Intitution Grant (UCSF Project Leader)
    Susan Chang; Fiscal Year: 2008
    ..The overall goal of this program is to more effectively treat patients with primary brain tumors, especially malignant glioma, with the purpose of increasing the duration and quality of survival. ..