cyclohexanecarboxylic acids

Summary

Top Publications

  1. ncbi Outcome reporting in industry-sponsored trials of gabapentin for off-label use
    S Swaroop Vedula
    Center for Clinical Trials, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    N Engl J Med 361:1963-71. 2009
  2. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
  3. ncbi Review of current guidelines on the care of postherpetic neuralgia
    Charles E Argoff
    Albany Medical College, Albany, NY 12208, USA
    Postgrad Med 123:134-42. 2011
  4. ncbi The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain
    S Abdi
    Department of Anesthesiology and Critical Care, The Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesth Analg 87:1360-6. 1998
  5. ncbi Cellular and molecular action of the putative GABA-mimetic, gabapentin
    Y P Maneuf
    Cambridge Biotechnology Ltd, PO Box 230, Cambridge CB2 1XJ, United Kingdom
    Cell Mol Life Sci 60:742-50. 2003
  6. ncbi Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group
    Augusto Caraceni
    Rehabilitation and Palliative Care Unit, National Cancer Institute of Milan, Via Venezian 1, 20133 Milan, Italy
    J Clin Oncol 22:2909-17. 2004
  7. ncbi Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study
    D Garcia-Borreguero
    Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
    Neurology 59:1573-9. 2002
  8. ncbi Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 318:735-40. 2006
  9. ncbi Implications and mechanism of action of gabapentin in neuropathic pain
    Ankesh Kukkar
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147002, Punjab, India
    Arch Pharm Res 36:237-51. 2013
  10. ncbi Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3)
    Ravi D Rao
    Department of Medical Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Cancer 110:2110-8. 2007

Detail Information

Publications245 found, 100 shown here

  1. ncbi Outcome reporting in industry-sponsored trials of gabapentin for off-label use
    S Swaroop Vedula
    Center for Clinical Trials, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    N Engl J Med 361:1963-71. 2009
    ..There is good evidence of selective outcome reporting in published reports of randomized trials...
  2. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
    ..Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies...
  3. ncbi Review of current guidelines on the care of postherpetic neuralgia
    Charles E Argoff
    Albany Medical College, Albany, NY 12208, USA
    Postgrad Med 123:134-42. 2011
    ....
  4. ncbi The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain
    S Abdi
    Department of Anesthesiology and Critical Care, The Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesth Analg 87:1360-6. 1998
    ..Finally, the site of action of LDC seems to be primarily in the periphery, and that of GBP is exclusively central, whereas that of AMI seems to have both peripheral and central components...
  5. ncbi Cellular and molecular action of the putative GABA-mimetic, gabapentin
    Y P Maneuf
    Cambridge Biotechnology Ltd, PO Box 230, Cambridge CB2 1XJ, United Kingdom
    Cell Mol Life Sci 60:742-50. 2003
    ....
  6. ncbi Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group
    Augusto Caraceni
    Rehabilitation and Palliative Care Unit, National Cancer Institute of Milan, Via Venezian 1, 20133 Milan, Italy
    J Clin Oncol 22:2909-17. 2004
    ..To determine the analgesic effect of the addition of gabapentin to opioids in the management of neuropathic cancer pain...
  7. ncbi Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study
    D Garcia-Borreguero
    Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
    Neurology 59:1573-9. 2002
    ..To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS)...
  8. ncbi Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 318:735-40. 2006
    ....
  9. ncbi Implications and mechanism of action of gabapentin in neuropathic pain
    Ankesh Kukkar
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147002, Punjab, India
    Arch Pharm Res 36:237-51. 2013
    ..It may also act on supra-spinal region to stimulate noradrenaline mediated descending inhibition, which contributes to its anti-hypersensitivity action in neuropathic pain...
  10. ncbi Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3)
    Ravi D Rao
    Department of Medical Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Cancer 110:2110-8. 2007
    ..On the basis of these data, a multicenter, double-blind, placebo-controlled, crossover, randomized trial was conducted to evaluate the effect of gabapentin on symptoms of chemotherapy-induced peripheral neuropathy (CIPN)...
  11. ncbi Gabapentin in the treatment of neuropathic pain
    Michael I Bennett
    St Gemma s Hospice, Leeds, UK
    Palliat Med 18:5-11. 2004
    ..In patients with neuropathic pain due to cancer, higher response rates might be observed with gabapentin when administered with opioids because of a synergistic interaction...
  12. ncbi Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia
    Shao Rui Chen
    Department of Anesthesiology, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Brain Res 1042:108-13. 2005
    ..These data provide complementary new information that gabapentin administered systemically and spinally can effectively relieve tactile allodynia in this animal model of postherpetic neuralgia...
  13. pmc Study of neurontin: titrate to effect, profile of safety (STEPS) trial: a narrative account of a gabapentin seeding trial
    Samuel D Krumholz
    Never Again Consulting LLC, Providence, Rhode Island, USA
    Arch Intern Med 171:1100-7. 2011
    ..Seeding trials, clinical studies conducted by pharmaceutical companies for marketing purposes, have rarely been described in detail...
  14. ncbi Pharmacokinetics of gabapentin after a single day and at steady state following the administration of gastric-retentive- extended-release and immediate-release tablets: a randomized, open-label, multiple-dose, three-way crossover, exploratory study in hea
    Toufigh Gordi
    Depomed, Inc, 1360 O Brien Drive, Menlo Park, CA 94025, USA
    Clin Ther 30:909-16. 2008
    ..Therefore, conventional sustained formulations would likely result in decreased bioavailability, as the dosage form would pass through the window of absorption before the drug could be completely released...
  15. ncbi Selective phosphodiesterase-4 inhibitors in chronic obstructive lung disease
    Francisco J Soto
    Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Curr Opin Pulm Med 11:129-34. 2005
    ..Novel anti-inflammatory therapies such as selective phosphodiesterase 4 (PDE4) inhibitors are in clinical development. Their potential role in the management of COPD is described in this review...
  16. ncbi Gabapentin in neuropathic pain syndromes: a randomised, double-blind, placebo-controlled trial
    M G Serpell
    University Department of Anaesthesia and Pain Management, Gartnavel General Hospital, 30 Shelly Court, G12 0YN, Scotland, Glasgow, UK
    Pain 99:557-66. 2002
    ..This study shows that gabapentin reduces pain and improves some quality-of-life measures in patients with a wide range of neuropathic pain syndromes...
  17. pmc Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit
    W Xiao
    Department of Anesthesia, Anesthesia Research Unit, McGill University, Montreal, Quebec, Canada
    Neuroscience 144:714-20. 2007
    ....
  18. pmc Spinal gabapentin and antinociception: mechanisms of action
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Korea
    J Korean Med Sci 18:255-61. 2003
    ....
  19. ncbi Mechanisms of the antinociceptive action of gabapentin
    Jen Kun Cheng
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei
    J Pharmacol Sci 100:471-86. 2006
    ....
  20. ncbi Multiple-steering QM-MM calculation of the free energy profile in chorismate mutase
    Alejandro Crespo
    Departamento de Quimica Inorganica, Analítica y Química Física and INQUIMAE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pab II, C1428EHA, Buenos Aires, Argentina
    J Am Chem Soc 127:6940-1. 2005
    ..The conversion reaction of chorismate to prephenate catalyzed by the Bacillus subtilis enzyme chorismate mutase has been chosen as an illustrative example...
  21. ncbi Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials
    Miroslav Backonja
    Department of Neurology, Anesthesiology, and Rehabilitation Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
    Clin Ther 25:81-104. 2003
    ..Tricyclic antidepressants are considered first-line agents for neuropathic pain, but their use is limited by unwanted side effects and a risk of cardiovascular mortality...
  22. ncbi Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis
    Wei Shi Zhang
    Department of Anesthesiology, Changhai Hospital, The Second Military Medical University, Shanghai, China
    Brain Res 1264:57-66. 2009
    ..These results provide the first identification that co-application of dexmedetomidine and gabapentin may synergistically antagonize inflammatory pain, and this might prove to be beneficial in the treatment of arthritic pain...
  23. ncbi Gabapentin for the treatment of pain in guillain-barré syndrome: a double-blinded, placebo-controlled, crossover study
    Chandra K Pandey
    Department of Anaesthesiology and Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Anesth Analg 95:1719-23, table of contents. 2002
    ..11 +/- 21.39 to 65.53 +/- 16.17 [ micro g]) in comparison to the placebo therapy period (319.44 +/- 25.08 to 316.67 +/- 24.25 [ micro g]) (P < 0.001)...
  24. ncbi Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin
    Kerstin Roeska
    Department of CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, Biberach an der Riss, Germany
    Pain 139:349-57. 2008
    ..Morphine and gabapentin had no anxiolytic-like effect in sham treated animals, thus their effect on anxiety-like behaviour in the neuropathic pain model is likely indirect via their anti-nociceptive properties...
  25. ncbi Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit
    Ning Qin
    Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19477 0776, USA
    Mol Pharmacol 62:485-96. 2002
    ..Whether the alpha(2)delta-4 subunit plays a distinct physiological role in select endocrine tissues remains to be demonstrated...
  26. ncbi Long-term regulation of voltage-gated Ca(2+) channels by gabapentin
    Myoung Goo Kang
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, The University of Iowa College of Medicine, 400 Eckstein Medical Research Building, Iowa City 52242, USA
    FEBS Lett 528:177-82. 2002
    ....
  27. ncbi Down-regulation of N-type voltage-activated Ca2+ channels by gabapentin
    Alfonso Vega-Hernández
    Department of Physiology, Biophysics and Neuroscience, CINVESTAV IPN, Mexico City, Mexico
    Cell Mol Neurobiol 22:185-90. 2002
    ..3. Consistent with this, radioligand binding experiments showed a comparable reduction in the total number of membrane HVA N-type channels after GBP treatment...
  28. ncbi Gabapentin in postamputation phantom limb pain: a randomized, double-blind, placebo-controlled, cross-over study
    Margaret Bone
    Departments of Anaesthesia and Pain Management, University Hospitals of Leicester NHS Trust, Leicester General Hosptial, Leicester, UK
    Reg Anesth Pain Med 27:481-6. 2002
    ..Gabapentin is effective in several syndromes of neuropathic pain. Therefore, we evaluated its analgesic efficacy in phantom limb pain...
  29. ncbi The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers
    Burkhard Gustorff
    Department of Anesthesia and General Intensive Care Medicine B, University of Vienna, Vienna, Austria
    Anesth Analg 98:401-7, table of contents. 2004
    ..With the exception of a small increase of HPTT in the sunburn (P = 0.02) gabapentin had no noticeable effect on either hyperalgesia. In conclusion, opioid analgesia was reliably demonstrated in this new extended pain model...
  30. ncbi Gabapentin augmentation therapy in bipolar depression
    Po W Wang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Bipolar Disord 4:296-301. 2002
    ..Gabapentin (GBP) may be useful in bipolar disorders, including as adjunctive therapy for bipolar depression, although controlled studies suggest inefficacy as primary treatment for mania or treatment-resistant rapid cycling...
  31. ncbi Presynaptic NMDA autoreceptors facilitate axon excitability: a new molecular target for the anticonvulsant gabapentin
    Luz M Suárez
    Servicio de Neurobiologia, Dpto de Investigación, Hospital Ramon y Cajal, Ctra de Colmenar Km 9, Madrid 28034, Spain
    Eur J Neurosci 21:197-209. 2005
    ..These findings suggest that sodium entry through presynaptic NMDA-R channels facilitates axon excitability. The interaction of gabapentin with this newly described mechanism might contribute to its therapeutic benefits...
  32. ncbi Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models
    Michael J Piesla
    Wyeth Research, Neuroscience Discovery Research, CN 8000, Princeton, NJ 08543, USA
    Brain Res 1295:89-98. 2009
    ..Gait may therefore constitute an alternative and potentially clinically relevant measure of pain due to inflammation...
  33. pmc Chorismic acid, a key metabolite in modification of tRNA
    T G Hagervall
    Department of Microbiology, Umea University, Sweden
    J Bacteriol 172:252-9. 1990
    ..This metabolic link between intermediary metabolism and translation also exists for another member of the family Enterobacteriaceae, Salmonella typhimurium, as well as for the distantly related gram-positive organism Bacillus subtilis...
  34. ncbi Gastroretentive gabapentin (G-GR) formulation reduces intensity of pain associated with postherpetic neuralgia (PHN)
    Christine N Sang
    Translational Pain Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin J Pain 29:281-8. 2013
    ..To evaluate the safety and efficacy of a once-daily gastroretentive formulation of gabapentin (G-GR; 1800 mg)...
  35. ncbi Clinical development of a once-daily gastroretentive formulation of gabapentin for treatment of postherpetic neuralgia: an overview
    Charles E Argoff
    Albany Medical College Neurology Group, 47 New Scotland Avenue, MC 70, Physicians Pavilion, 1st Floor, Albany, NY 12208, USA
    Expert Opin Drug Deliv 9:1147-60. 2012
    ..G-GR slowly releases the drug from the tablet to the upper small intestine, where gabapentin is best absorbed, over approximately 10 h...
  36. ncbi A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin
    Howard N Bockbrader
    Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Clin Pharmacokinet 49:661-9. 2010
    ..In conclusion, pregabalin appears to have some distinct pharmacokinetic advantages over gabapentin that may translate into an improved pharmacodynamic effect...
  37. ncbi The intestinal absorption mechanism of gabapentin makes it appropriate for gastroretentive delivery
    Cuiping Chen
    Depomed Inc, 1360 O Brien Drive, Menlo Park, CA 94025, USA
    Curr Clin Pharmacol 8:67-72. 2013
    ..The net result is a once-daily formulation of gabapentin that is well tolerated and efficacious for the treatment of PHN...
  38. ncbi Once-daily gastroretentive gabapentin for postherpetic neuralgia: integrated efficacy, time to onset of pain relief and safety analyses of data from two phase 3, multicenter, randomized, double-blind, placebo-controlled studies
    Richard L Rauck
    Center for Clinical Research, Winston Salem, North Carolina, USA
    J Pain Symptom Manage 46:219-28. 2013
    ..Treatment options for postherpetic neuralgia (PHN), a complication of herpes zoster, are commonly unsatisfactory and associated with adverse events...
  39. pmc Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis
    Jared B Parker
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States
    Biochemistry 51:3241-51. 2012
    ..On the other hand, acceleration of the allylic isomerization by BacB gives a mixture of the E- and Z-geometric isomers of the 7R- product, indicating some rerouting of the flux, likely through dienolate geometric isomers...
  40. pmc Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies
    Fatma Sultan Kilic
    Department of Pharmacology, Eskisehir Osmangazi University, Medical School, Eskisehir, Turkey
    Indian J Med Res 135:630-5. 2012
    ..Thus, clinical studies have been carried out especially for neuropathic syndroms. This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats...
  41. ncbi Gabapentin extended-release tablets for the treatment of patients with postherpetic neuralgia: a randomized, double-blind, placebo-controlled, multicentre study
    Mark S Wallace
    Center for Pain Medicine, University of California, San Diego School of Medicine, La Jolla, California 92037 765092093, USA
    Clin Drug Investig 30:765-76. 2010
    ..Postherpetic neuralgia (PHN) is a neuropathic pain syndrome that may develop subsequent to healing of herpes zoster rash...
  42. pmc Real-world treatment of post-herpetic neuralgia with gabapentin or pregabalin
    Phaedra Johnson
    Health Economics and Outcomes Research, OptumInsight, 12125 Technology Drive MN002 0258, Eden Prairie, MN 55344, USA
    Clin Drug Investig 33:35-44. 2013
    ..This study examines dosing patterns, therapy outcomes, healthcare utilization and costs of patients with PHN who initiate treatment with gabapentin or pregabalin...
  43. ncbi The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2
    Alexandra Tran-Van-Minh
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 30:12856-67. 2010
    ..In contrast, the internalization of α2δ-2 was unaffected by GBP. We conclude that GBP acts by preventing the recycling of α2δ-2 from Rab11-positive recycling endosomes to the plasma membrane...
  44. ncbi Pharmacokinetics, efficacy, and tolerability of a once-daily gastroretentive dosage form of gabapentin for the treatment of postherpetic neuralgia
    Cuiping Chen
    Depomed Inc, Newark, California 94560, USA
    J Pharm Sci 102:1155-64. 2013
    ..The effect of GR formulation on efficacy and the incidence of adverse events that are commonly associated with G-IR treatment in PHN patients are also discussed...
  45. ncbi α,β-Unsaturated monoterpene acid glucose esters: structural diversity, bioactivities and functional roles
    Jason Q D Goodger
    School of Botany, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Phytochemistry 72:2259-66. 2011
    ..Finally we discuss how the use of a recently developed protocol to isolate secretory cavities in a functional state could be used in conjunction with systems biology approaches to help characterize their biosynthesis and roles in plants...
  46. ncbi The next generation of PDE4 inhibitors
    Z Huang
    Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire, Dorval, Quebec, H9R 4P8, Canada
    Curr Opin Chem Biol 5:432-8. 2001
    ..The recent developments in understanding PDE4 catalysis, inhibitor binding and their emetic response should facilitate the design of the next generation of PDE4 inhibitors...
  47. pmc Hemodynamic effects of gabapentin in rats
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Korea
    J Korean Med Sci 18:478-82. 2003
    ..Intracerebroventricular gabapentin increased systolic and diastolic blood pressure, but there is no statistically difference in blood pressure change according to the dose...
  48. pmc Implementation of a publication strategy in the context of reporting biases. A case study based on new documents from Neurontin litigation
    S Swaroop Vedula
    Department of Epidemiology, Center for Clinical Trials, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Mailroom W5010, Baltimore, MD 21205, USA
    Trials 13:136. 2012
    ..migraine prophylaxis, treatment of bipolar disorders, neuropathic pain, and nociceptive pain...
  49. ncbi Synthesis of the monoterpenoid esters cypellocarpin C and cuniloside B and evidence for their widespread occurrence in Eucalyptus
    Zalihe Hakki
    Bio21 Molecular Science and Biotechnology Institute and School of Chemistry, The University of Melbourne, Victoria 3010, Australia
    Carbohydr Res 345:2079-84. 2010
    ..The widespread occurrence of these carbohydrate monoterpenoid esters supports their roles in essential oil biosynthesis or mobilization from sites of synthesis to secretory cavity lumena...
  50. ncbi Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes
    H C Gong
    Department of Molecular Sciences, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    J Membr Biol 184:35-43. 2001
    ..72 +/- 9 nm). Inhibition of gabapentin binding to alpha2delta-2 by selected amino acids and gabapentin analogs produced a binding profile similar, but not identical to that of alpha2delta-1...
  51. ncbi The role of gabapentin in treating diseases with cutaneous manifestations and pain
    Noah Scheinfeld
    Department of Dermatology, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Int J Dermatol 42:491-5. 2003
    ..It appears to be a promising agent in the treatment of pain, alterations of sensation and pruritus associated with dermatological disease, but no review of these uses exists...
  52. pmc The interaction of gabapentin and N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on mechanical allodynia in rats with a spinal nerve ligation
    Jong Yeon Park
    Department of Anesthesiology and Pain Medicine, University of Ulsan, College of Medicine, Seoul Asan Medical Center, Songpa Gu, Seoul, Korea
    J Korean Med Sci 23:678-84. 2008
    ..These results suggest that activation of adenosine A1 receptors at the spinal level is required for the synergistic interaction on the mechanical allodynia...
  53. ncbi Eucalmaidins A-E, (+)-oleuropeic acid derivatives from the fresh leaves of Eucalyptus maideni
    Li Wen Tian
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People s Republic of China
    J Nat Prod 72:1608-11. 2009
    ..Of the tested compounds, only quercetin showed slight anti-herpes simplex virus 1 (HSV-1) activity in vitro...
  54. ncbi The use of gabapentin for the treatment of postherpetic neuralgia
    Devada Singh
    Pharmacy Practice, Nova Southeastern University College of Pharmacy Davie Campus, Fort Lauderdale, Florida 33328 2018, USA
    Clin Ther 25:852-89. 2003
    ..Varicella-zoster virus causes chickenpox and can reemerge later in life to cause herpes zoster or shingles. One of the most common and disabling complications of herpes zoster is postherpetic neuralgia (PHN)...
  55. ncbi Efficacy and tolerability of gastric-retentive gabapentin for the treatment of postherpetic neuralgia: results of a double-blind, randomized, placebo-controlled clinical trial
    Gordon Irving
    Swedish Pain and Headache Center, Seattle, WA 98104, USA
    Clin J Pain 25:185-92. 2009
    ..To determine the efficacy and safety of a gastric-retentive, extended-release gabapentin (gabapentin ER) taken once or twice daily for treatment of postherpetic neuralgia...
  56. ncbi False Claims Act prosecution did not deter off-label drug use in the case of neurontin
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Health Aff (Millwood) 30:2318-27. 2011
    ....
  57. ncbi Gabapentin inhibits calcium currents in isolated rat brain neurons
    A Stefani
    IRCCS Ospedale S Lucia, Rome, Italy
    Neuropharmacology 37:83-91. 1998
    ....
  58. ncbi Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain
    J K Cheng
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 92:1126-31. 2000
    ....
  59. ncbi Treatment of neuropathic pain: an overview of recent guidelines
    Alec B O'Connor
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Med 122:S22-32. 2009
    ..For all treatments for neuropathic pain, long-term studies, head-to-head comparisons, and studies of treatment combinations are a priority for future research...
  60. ncbi Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature
    M A Mellegers
    University of Maastricht, The Netherlands
    Clin J Pain 17:284-95. 2001
    ..Well-designed controlled trials may provide insight into differential symptom sensitivity to the drug...
  61. pmc Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones
    K G Sutton
    Department of Biology, Pfizer Global R and D, Cambridge Laboratories, Cambridge, CB2 2QB
    Br J Pharmacol 135:257-65. 2002
    ..8. The present study is the first to demonstrate that gabapentin directly mediates inhibition of voltage-gated Ca(2+) influx in DRG neurones, providing a potential means for gabapentin to effectively mediate spinal anti-nociception...
  62. pmc Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin
    Jan Hendrich
    Laboratory for Cellular and Molecular Neuroscience, Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:3628-33. 2008
    ....
  63. ncbi Narrative review: the promotion of gabapentin: an analysis of internal industry documents
    Michael A Steinman
    San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94143, USA
    Ann Intern Med 145:284-93. 2006
    ..Such documents have become available through litigation concerning the promotion of gabapentin (Neurontin, Pfizer, Inc., New York, New York) for off-label uses...
  64. ncbi Stimulus-dependent modulation of [(3)H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin
    D J Dooley
    Department of Neuroscience Therapeutics, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    J Pharmacol Exp Ther 295:1086-93. 2000
    ..This type of modulation of neurotransmitter release may be integral to the clinical pharmacology of these drugs...
  65. ncbi A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain
    T J Coderre
    Department of Anesthesia, McGill University, Montreal, Canada
    J Neurochem 100:1289-99. 2007
    ..Riluzole's pronounced suppressive effects on spinal EAA levels is attributed to its established role as a glutamate release inhibitor and an enhancer of glutamate transporter activity...
  66. ncbi alpha2delta and the mechanism of action of gabapentin in the treatment of pain
    Y P Maneuf
    Cambridge Biotechnology Ltd, Biovitrum AB, Babraham Research Campus, Cambridge CB2 4AT, UK
    Semin Cell Dev Biol 17:565-70. 2006
    ....
  67. pmc Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase
    Y P Maneuf
    Pfizer Global R and D, Cambridge Laboratories, University of Cambridge Forvie Site, Robinson Way, Cambridge CB2 2QB
    Br J Pharmacol 134:237-40. 2001
    ..We suggest that these results may be of relevance to the antihyperalgesic properties of gabapentin, in conditions where concomitant release of substance P and CGRP produces activation of PKC and adenylyl cyclase respectively...
  68. ncbi Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study
    A S Rice
    Pain Research Group, Department of Anaesthetics, Imperial College School of Medicine, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW10 9NH, UK
    Pain 94:215-24. 2001
    ..The most common adverse events were dizziness and somnolence, particularly during the titration phase. Thus, this study confirms the role of gabapentin as an efficacious and well-tolerated treatment for postherpetic neuralgia...
  69. ncbi New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine
    A J Rowan
    VA Medical Center, Bronx, NY 10468, USA
    Neurology 64:1868-73. 2005
    ..To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy...
  70. ncbi Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs
    Emer M Garry
    Division of Veterinary Biomedical Sciences, Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    Pain 118:97-111. 2005
    ....
  71. ncbi Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
    Brian J Lipworth
    Department of Medicine and Therapeutics, Asthma and Allergy Research Group, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Lancet 365:167-75. 2005
    ..Ultimately, clinicians will want to know whether PDE4 inhibitors are anything more than expensive "designer" theophylline, the archetypal non-selective phosphodiesterase inhibitor...
  72. ncbi Gabapentin for the prevention of postoperative pain after vaginal hysterectomy
    Michael G F Rorarius
    Department of Anaesthesiology and Intensive Care, Tampere University Hospital, P O Box 2000, 33521 Tampere, Finland
    Pain 110:175-81. 2004
    ..No preoperative differences between the two groups were encountered with respect to the side effects of the premedication. However, 15 mg oxazepam was more effective in relieving preoperative anxiety than 1200 mg gabapentin...
  73. ncbi Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats
    Rachel Wodarski
    Neurorestoration Group, Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, UK
    Eur J Pain 13:807-11. 2009
    ..Consequently, spinal microglial activation is a key mechanism underlying diabetic neuropathy. Furthermore, we suggest that Gabapentin may exert its anti-allodynic actions partially through alterations of microglial cell function...
  74. ncbi Gabapentin selectively reduces persistent sodium current in injured type-A dorsal root ganglion neurons
    Rui Hua Yang
    epartment of Occupational and Environmental Health, The Fourth Military Medical University, Xi an 710032, PR China
    Pain 143:48-55. 2009
    ..The results suggest that GBP decreased the amplitude of resonance and abolished the SMPO of A-type DRG neurons through the inhibition of I(NaP), and thus inhibited the SMPO dependent repetitive and bursting firings...
  75. ncbi Alternative splicing of the Ca2+ channel beta4 subunit confers specificity for gabapentin inhibition of Cav2.1 trafficking
    Patrice M Mich
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    Mol Pharmacol 74:904-12. 2008
    ..This mechanism may help to explain why gabapentin is both effective and selective in the treatment of neuropathic pain states that involve up-regulation of alpha2delta subunits...
  76. ncbi Differential analgesic effects of morphine and gabapentin on behavioural measures of pain and disability in a model of osteoarthritis pain in rats
    Jean Laurent Vonsy
    University College London, Neuroscience, Physiology and Pharmacology, London WC1E 6BT, UK
    Eur J Pain 13:786-93. 2009
    ..In terms of translational research, the effects of morphine and gabapentin validate the model and suggest trials of these therapeutic approaches in OA patients...
  77. ncbi Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study
    Torsten E Gordh
    Multidisciplinary Pain Center, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Pain 138:255-66. 2008
    ..023) and Clinician (p=0.037) Global Impression of Change indicated a better response with gabapentin compared with placebo. Gabapentin was well tolerated. The most common adverse effects were dizziness and tiredness...
  78. pmc The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy
    V C J Wallace
    Pain Research Group, Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London, UK
    Br J Pharmacol 151:1117-28. 2007
    ....
  79. pmc Nummular headache: another case treated with gabapentin
    Marco Trucco
    J Headache Pain 8:137-8. 2007
  80. ncbi The effects of intrathecal gabapentin on spinal morphine tolerance in the rat tail-flick and paw pressure tests
    C Hansen
    Department of Pharmacology and Toxicology, Kingston General Hospital, Queen s University, Ontario, Canada
    Anesth Analg 99:1180-4, table of contents. 2004
    ..Future studies are required to examine the respective roles of supraspinal and peripheral sites of GBP-morphine interaction and to investigate the mechanisms underlying the action of GBP on opioid tolerance...
  81. ncbi Effectiveness of gabapentin for the treatment of behavioral disorders in dementia
    N Herrmann
    Division of Geriatric Psychiatry, University of Toronto, Ontario, Canada
    J Clin Psychopharmacol 20:90-3. 2000
    ..Gabapentin may have a role in treating a subgroup of dementia patients with severe behavioral disorders who have not responded to neuroleptics...
  82. ncbi Neurotransmitter mechanisms in gabapentin antinociception
    R K Dixit
    Department of Pharmacology, PGIMER, Chandigarh, India
    Pharmacology 65:198-203. 2002
    ..c.) antinociception except for L-arginine which increased the pain score from 1.68 +/- 0.29 (gabapentin) to 2.29 +/- 0.41. Results suggest the involvement of L-arginine nitric oxide pathways in gabapentin antinociception...
  83. ncbi The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat
    S Patel
    Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK
    Pain 90:217-26. 2001
    ..These data indicate that CGP35024 and L-baclofen modulate nociceptive transmission in the spinal cord to inhibit neuropathic hyperalgesia, and that CGP35024 has a therapeutic window for antihyperalgesia over spasmolysis...
  84. ncbi Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia
    Robert W Hurley
    Department of Anesthesia and Critical Care, and Committee on Neurobiology, University of Chicago, Illinois, USA
    Anesthesiology 97:1263-73. 2002
    ..This study characterized the manner in which gabapentin or pregabalin interacts with naproxen to suppress thermal hyperalgesia and inflammation in the carrageenan model of peripheral inflammation...
  85. ncbi Gabapentin-induced paradoxical exacerbation of psychosis in a patient with schizophrenia
    Karin Jablonowski
    Can J Psychiatry 47:975-6. 2002
  86. ncbi Gabapentin enhances the analgesic effect of morphine in healthy volunteers
    K Eckhardt
    Dr Margarete Fischer Bosch Institut fuer Klinische Pharmakologie, Stuttgart, Germany
    Anesth Analg 91:185-91. 2000
    ..These results and the good tolerability of GBP should favor clinical trials investigating the clinical relevance of the combination of morphine and GBP for treating severe pain...
  87. ncbi The use of gabapentin in chronic cluster headache patients refractory to first-line therapy
    S Schuh-Hofer
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin
    Eur J Neurol 14:694-6. 2007
    ..We conclude that gabapentin may be offered as treatment trial in patients refractory to first-line treatment. However, patients may fail to respond to treatment and drug tolerance may occur with time...
  88. ncbi Gabapentin suppresses spasticity in the spinal cord-injured rat
    P H Kitzman
    Department of Rehabilitation Science, The University of Kentucky, 210D Charles T Wethington Building, 900 South Limestone Avenue, Lexington, KY 40536 0200, USA
    Neuroscience 149:813-21. 2007
    ..The present study examined the efficacy of gabapentin, an agent that has been shown to reduce glutamate release, in managing spasticity within the tail musculature...
  89. ncbi Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats
    V Chapman
    Department of Pharmacology, University College London, UK
    Pain 75:261-72. 1998
    ..Further studies at the spinal level may shed light on the physiology and pharmacology of the aberrant processes associated with neuropathic pain...
  90. ncbi Reduction of postherpetic neuralgia in herpes zoster
    M Vander Straten
    Department of Dermatology, University of Texas Medical Branch, UTMB Center for Clinical Studies, 2060 Space Park Drive, Galveston, TX 77058, USA
    J Cutan Med Surg 5:409-16. 2001
    ..Widespread use of the varicella vaccine may lead to secondary reductions in PHN in the distant future...
  91. ncbi Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  92. pmc Persistent primary thunderclap headache responsive to gabapentin
    Ivan Garza
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Headache Pain 7:419-21. 2006
    ..Whether gabapentin may help other primary thunderclap headache sufferers or not remains unclear. Further research is needed...
  93. ncbi An East-West approach to the management of central post-stroke pain
    Hwee Ling Yen
    Department of Rehabilitation Medicine, Tan Tock Seng Hospital, Singapore, Singapore
    Cerebrovasc Dis 16:27-30. 2003
    ..To the best of our knowledge, the use of acupuncture for the treatment of CPSP has not been previously reported...
  94. ncbi The effects of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons
    A Stefani
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Ospedale Santa Lucia, Via Ardeatina 306, 00179, Rome, Italy
    Epilepsy Res 43:239-48. 2001
    ..These unconventional effects might underlie its efficacy in a variety of diseases which involve periodic discharge patterns as neuropathic pain or essential tremor...
  95. ncbi Calcium channel alpha(2)delta subunits-structure and Gabapentin binding
    E Marais
    , , Germany
    Mol Pharmacol 59:1243-8. 2001
    ..alpha(2)delta-1 and alpha(2)delta-2, but not alpha(2)delta-3, were found to bind gabapentin. The K(d) value of gabapentin binding to alpha(2)delta-2 was 153 nM compared with the higher affinity binding to alpha(2)delta-1 (K(d) = 59 nM)...
  96. ncbi A placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathies
    K Hahn
    Department of Neurology, Charite Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    J Neurol 251:1260-6. 2004
    ..The pathogenesis is unknown and the treatment very limited. Gabapentin (GBP) is effective in painful diabetic neuropathy and postherpetic neuralgia and its effectiveness on painful HIV-SN has been reported anecdotally...
  97. ncbi Modulation of K+-evoked [3H]-noradrenaline release from rat and human brain slices by gabapentin: involvement of KATP channels
    T M Freiman
    , Neurozentrum, Freiburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 363:537-42. 2001
    ....
  98. ncbi Gabapentin: an alternative to the cyclooxygenase-2 inhibitors for perioperative pain management
    A Turan
    Department of Anaesthesiology, Trakya University, Edirne, Turkey
    Anesth Analg 102:175-81. 2006
    ..Gabapentin (1.2 g/d PO) appears to be an acceptable alternative to rofecoxib (50 mg/d PO) for short-term use as an adjuvant to opioid analgesics in patients undergoing lower abdominal surgery...
  99. ncbi Inhibitory mechanisms of gabapentin, an antiseizure drug, on platelet aggregation
    Chi Feng Pan
    Graduate Institute of Medical Sciences and Topnotch Stroke Research Center, Taipei Medical University, Taipei, Taiwan
    J Pharm Pharmacol 59:1255-61. 2007
    ..Thus, it is possible that gabapentin treatment, alone or in combination with other antiplatelet drugs, may induce or potentiate inhibition of platelet aggregation, which may affect haemostasis in-vivo...
  100. ncbi Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn
    M Shimoyama
    Department of Physiology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba shi, Japan
    Pain 85:405-14. 2000
    ..The antinociceptive effects of GBP may involve the inhibition of the release of excitatory amino acids from presynaptic terminals...
  101. ncbi Role of spinal voltage-dependent calcium channel alpha 2 delta-1 subunit in the expression of a neuropathic pain-like state in mice
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Life Sci 80:2015-24. 2007
    ..Furthermore, the present data provide evidence that the neuropathic pain may be effectively controlled by repeated treatment with GBP at the early stage...

Research Grants63

  1. Effects of Amino Acid Therapy on Hot Flashes in Postmenopausal Women
    Thomas Guttuso; Fiscal Year: 2007
    ..The applicant will also attend two didactic training seminars in complementary & alternative medicine at The Osher Institute at Harvard Medical School and at the Duke Center for Integrative Medicine. ..
  2. CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITY
    Charles Loprinzi; Fiscal Year: 2003
    ..abstract_text> ..
  3. Peripherial and Central Mechanisms of Tinnitus Generat
    Carol Bauer; Fiscal Year: 2006
    ..Safe and efficacious therapy for this prevalent and often debilitating problem can only occur with improved understanding of the disorder. ..
  4. Phase III Trial of Minocycline in ALS-II Data Center
    Robert Miller; Fiscal Year: 2007
    ..The details of data management are described, including the methods for quality control, security and information technology. Finally, the analytic plan is described in full. ..
  5. Gabapentin as an Adjunct to Naltrexone for Alcoholism
    Raymond Anton; Fiscal Year: 2006
    ..This evaluation of a novel treatment will allow us to better understand combined pharmacotherapy and develop a new paradigm for medications development for alcoholism. ..
  6. Intranasal Methamphetamine: A Pharmacotherapy Model
    Carl Hart; Fiscal Year: 2009
    ....
  7. TRAINING IN FUNCTIONAL IMAGING AND ALCOHOL WITHDRAWAL
    DONALD MYRICK; Fiscal Year: 2004
    ....
  8. Drug Effects on Behavior: Workplace Implications
    Carl Hart; Fiscal Year: 2008
    ..Together, the data from the proposed studies will have substantial public health impact and will serve both educational and public policy functions. ..
  9. Emory Conte Center for the Neuroscience of Mental Disorders
    Becky Kinkead; Fiscal Year: 2008
    ..abstract_text> ..
  10. ADENOSINE AND RENAL INJURY
    MARK OKUSA; Fiscal Year: 2009
    ..These experiments also will shed light on the role of inflammation in the etiology of DN and provide insights into other potential anti-inflammatory therapeutic strategies. ..
  11. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2006
    ..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
  12. Management of Chronic Pain in Rehabilitation Medicine
    Mark Jensen; Fiscal Year: 2006
    ..A Scientific Core will provide scientific direction, project coordination, data collection and management, statistical support, and shared scientific expertise. ..
  13. Rehabilitation of Spinal Cord Injury-Related Pain
    Mark Jensen; Fiscal Year: 2006
    ..abstract_text> ..
  14. Collaborative Tinnitus Research at Washington University
    Jay F Piccirillo; Fiscal Year: 2010
    ..This study is unique since all subjects will have thorough neurocognitive testing and PET scan imaging at baseline, after sham, and after active treatment. ..
  15. St. John's Wort for tobacco cessation
    Amit Sood; Fiscal Year: 2006
    ..This study is anticipated to provide the data needed to develop a larger randomized controlled clinical trial submitted through the R01 funding mechanism to NCCAM. [unreadable] [unreadable]..
  16. Antidepressant Treatment and Suicidality: Biostatistical/Methodological Solutions
    Robert Gibbons; Fiscal Year: 2006
    ..Collaboration with members of the VA (Cunningham, Valenstein), Kaiser Permanente (Clarke, Gullion), PHARMO (Erkens) and the Indian Health Service (Perez) is an integral part of the proposal. [unreadable] [unreadable] [unreadable]..
  17. Tiagabine for Cocaine Dependence in Methadone Treatment
    GERARDO GONZALEZ HADDAD; Fiscal Year: 2007
    ....
  18. Lysophosphatidic Acid Receptors and Acute Renal Failure
    MARK OKUSA; Fiscal Year: 2007
    ..Furthermore, these studies will provide the foundation for future human clinical trials of acute renal failure and renal allograft preservation. ..
  19. Hyperalgesia in Methadone Patients: Can it be Treated?
    Margaret Compton; Fiscal Year: 2007
    ..abstract_text> ..
  20. Modified Behavioral Treatment for Cocaine Patients with Cognitive Deficits
    Efrat Aharonovich; Fiscal Year: 2010
    ....
  21. Training in Comorbidity of Alcoholism and Mental Illness
    SARAH BOOK; Fiscal Year: 2007
    ..Her ultimate goal is to become an independent clinical researcher, while still treating patients and providing didactic substance abuse education to future generations of medical professionals. ..
  22. SYNTHESIS OF ANTIBIOTICS
    Andrew G Myers; Fiscal Year: 2010
    ..In addition, we will undertake basic studies to explore the feasibility of a novel macropolycyclization route to produce the new class of antibiotics known as the pyrrocidines. ..
  23. Role of Intraspinal Plasticity in Autonomic Dysreflexia
    Alexander Rabchevsky; Fiscal Year: 2008
    ..This information will form the basis for developing potential treatments for this common and debilitating complication of SCI. ..
  24. CBT and Modafinil for Cocaine Addiction
    Robert Malcolm; Fiscal Year: 2009
    ....
  25. Pharmacological fMRI to Identify New Anxiolytics: A Human Bioassay
    Murray Stein; Fiscal Year: 2008
    ..Enhancing the development of new treatments for anxiety is a public health priority. The projects proposed in this application have the potential to achieve this important aim. [unreadable] [unreadable] [unreadable]..
  26. Adolescent Exposure to Psychostimulants: Role of nNOS
    Yossef Itzhak; Fiscal Year: 2008
    ..Results of these studies would provide new information on mechanisms that underlie the development of hypersensitivity to these drugs from adolescence through adulthood. ..
  27. Gabapentin for Smoking Abstinence
    Amit Sood; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  29. Mixed-Effects ZIP Models--Mental Health Service Research
    Robert Gibbons; Fiscal Year: 2004
    ..abstract_text> ..
  30. ALTERING BEHAVIORAL RISK FOR DRUG DEPENDENCE
    DON CHEREK; Fiscal Year: 2001
    ..Pharmacological effects of these therapeutics drugs on such behavior in a high risk population may provide information relating to alternative strategies in dealing with drug dependence. ..
  31. Gabapentin vs Estrogen for the Treatment of Hot Flushes
    SIREESHA REDDY; Fiscal Year: 2004
    ..Pilot data from these two aims will permit estimates of sample-size requirements for a full-scale randomized trial, and of the overall feasibility and cost of such a trial. ..
  32. BIOSYNTHESIS OF BETA LACTAM ANTIBIOTICS
    Craig Townsend; Fiscal Year: 2003
    ..These insights will be extended to examination of beta- lactam formation in the prephytotoxin tabtoxin. ..
  33. GABAPENTIN THERAPY FOR THE PRURITUS OF CHOLESTASIS
    NORA BERGASA; Fiscal Year: 2002
    ..Scratching activity will be measured by a stem designed specifically to record this behavior. The potential outcome of this study is the identification of an effective form of therapy for the pruritus of cholestasis. ..
  34. IMPROVING CARE FOR PANIC DISORDER IN PRIMARY CARE
    Murray Stein; Fiscal Year: 2002
    ..abstract_text> ..
  35. THC AND MARIJUANA--EFFECTS IN INDIVIDUALS WITH HIV/AIDS
    Margaret Haney; Fiscal Year: 2002
    ....
  36. BEHAVIORAL MECHANISM IN HIGH RISK POPULATIONS
    DON CHEREK; Fiscal Year: 2001
    ..Demonstrating such fundamental differences may lead to different approaches in attempts to modify antisocial behavior among high risk populations with such behavioral tendencies. ..
  37. Cognitive Deficits: Treatment Outcome in Cocaine Abusers
    Efrat Aharonovich; Fiscal Year: 2004
    ..abstract_text> ..
  38. CHRONIC CENTRAL PAIN IN SPINAL CORD INJURY
    CLAIRE HULSEBOSCH; Fiscal Year: 2005
    ..There are three cores: an administrative core, an animal core and a morphology core. The results for these studies will guide the development of strategic interventions to improve functional outcome after SCI. ..
  39. PHYSIOLOGY OF ESTROGEN'S MOOD EFFECT IN MENOPAUSAL WOMEN
    Hadine Joffe; Fiscal Year: 2007
    ..Such training will lay the foundation for a career of clinical investigation into the physiology of perimenopausal depression and the impact of hot flushes on sleep, mood, and quality-of-life. ..
  40. Substituted Amphetamines: NO-Dependent Mechanisms
    Yossef Itzhak; Fiscal Year: 2005
    ....
  41. SMART: Improving Detection & Outcome of Psychiatric Comorbidity in Drug Treatment
    Carlos Blanco; Fiscal Year: 2010
    ..abstract_text> ..
  42. EFFECTS OF DIOXINS (TCDD) ON CARDIAC ION CHANNELS
    Desuo Wang; Fiscal Year: 2003
    ....
  43. Genetics, Brain Activity, and Relapse to Alcoholism
    Kirk Brower; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  44. Multidiscipli. GCRC-Mentorship Program in Womens Health
    Lorraine Fitzpatrick; Fiscal Year: 2003
    ..abstract_text> ..
  45. Neuropharmacology of Pain in Spinal Cord Injury
    Christine Sang; Fiscal Year: 2005
    ..abstract_text> ..
  46. Substance Use Comorbidity Care: Evidence-Based Stepped Strategies for Depression
    Carlos Blanco; Fiscal Year: 2010
    ..abstract_text> ..
  47. Bipolar Statistical Summit:Methodologies to Advance Long Term Intervention Trials
    Charles Bowden; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  48. PERIPHERAL SOMATOSTATIN CONTROLS INFLAMMATORY PAIN
    Susan Carlton; Fiscal Year: 2004
    ..Peripheral SST receptors offer novel targets for nociceptor modulation and are likely targets for further development of non-opioid therapies to aid in reducing the pain and long-term deleterious changes that can accompany inflammation. ..
  49. 400 MHz NMR Spectrometer for Shared Use
    Craig Townsend; Fiscal Year: 2004
    ..9) investigation of the hypothesis that aromatic amino acids are required to specify a distinct conformational state by NMR spin relaxation techniques, to elucidate important parameters for protein design. ..
  50. Screening for comorbidity in substance abuse clinics
    Carlos Blanco; Fiscal Year: 2004
    ..abstract_text> ..
  51. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  52. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. Preventing Psychiatric Sequelae of Traumatic Injury
    Murray Stein; Fiscal Year: 2003
    ..Findings will provide justification for and information about optimal parameters (e.g., subject selection; sample size; dose and duration) for a future randomized controlled trial (RCT). ..
  54. TeleCare Management of Pain and Depression in Cancer
    Kurt Kroenke; Fiscal Year: 2009
    ..Furthermore, if proven effective for depression and pain, TCM could readily be expanded to reducing barriers and improving care of other cancer-related symptoms. ..
  55. Gabapentin for Relief of Idiopathic Subjective Tinnitus
    Jay Piccirillo; Fiscal Year: 2005
    ..The findings from this research could have significant health impact for a large number of Americans. ..
  56. Medialization VS. Reinnervation For Vocal Cord Paralysis
    Jay Piccirillo; Fiscal Year: 2004
    ..These data will be used to test the hypothesis that reinnervation gives better results than medialization in patients with UVFP. ..
  57. INCLUSION OF COMORBIDITY IN ONCOLOGY DATA REGISTRIES
    Jay Piccirillo; Fiscal Year: 2002
    ..An alternative, low-cost option to train registrars to code comorbidity and provide updated information is to use the Internet via the World Wide Web. ..
  58. Comparison of Comorbidity Collection Methods
    Jay Piccirillo; Fiscal Year: 2008
    ..abstract_text> ..
  59. CLINICAL INVESTIGATOR TRAINING ENHANCEMENT: CITE PROGRAM
    Kurt Kroenke; Fiscal Year: 2004
    ..abstract_text> ..
  60. Comorbidity prognostic Impact in Elderly Cancer Patients
    Jay Piccirillo; Fiscal Year: 2005
    ..abstract_text> ..