chlorogenic acid

Summary

Summary: A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).

Top Publications

  1. ncbi Antioxidant activity of polyphenolics in diets. Rate constants of reactions of chlorogenic acid and caffeic acid with reactive species of oxygen and nitrogen
    Y Kono
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Japan
    Biochim Biophys Acta 1335:335-42. 1997
  2. pmc Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes
    Khang Wei Ong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    PLoS ONE 7:e32718. 2012
  3. ncbi Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties
    Nari Yun
    School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi do 440 746, South Korea
    J Nutr Biochem 23:1249-55. 2012
  4. ncbi Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid
    Michel David dos Santos
    University of Sao Paulo, Faculty of Pharmaceutical Sciences of Ribeirao Preto, Brazil
    Biol Pharm Bull 29:2236-40. 2006
  5. ncbi In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid
    Yuki Sato
    Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Int J Pharm 403:136-8. 2011
  6. ncbi Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation
    Jianhua Shan
    Nanjing Normal University, Jiangsu, PR China
    Int Immunopharmacol 9:1042-8. 2009
  7. ncbi Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice
    Seung Hwan Kwon
    Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    Eur J Pharmacol 649:210-7. 2010
  8. ncbi Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice
    Ae Sim Cho
    Department of Nutrition Education, Graduate School of Education, Sunchon National University, Suncheon 540 742, Republic of Korea
    Food Chem Toxicol 48:937-43. 2010
  9. ncbi Antioxidant and DNA-protective activities of chlorogenic acid isomers
    Jian guo Xu
    College of Engineering, Shanxi Normal University, Linfen City, 041004, China
    J Agric Food Chem 60:11625-30. 2012
  10. ncbi On-line HPLC-DPPH screening method for evaluation of radical scavenging phenols extracted from apples (Malus domestica L.)
    Donata Bandoniene
    Institute of Food Chemistry and Technology, Graz University of Technology, Petersgasse 12, A 8010 Graz, Austria
    J Agric Food Chem 50:2482-7. 2002

Detail Information

Publications268 found, 100 shown here

  1. ncbi Antioxidant activity of polyphenolics in diets. Rate constants of reactions of chlorogenic acid and caffeic acid with reactive species of oxygen and nitrogen
    Y Kono
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Japan
    Biochim Biophys Acta 1335:335-42. 1997
    Phenolic non-flavonoid compounds in diets, such as chlorogenic acid and caffeic acid are widely recognized to be antioxidants. However, it is not known how these phenolics scavenge reactive species of oxygen and nitrogen...
  2. pmc Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes
    Khang Wei Ong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    PLoS ONE 7:e32718. 2012
    b>Chlorogenic acid (CGA) has been shown to delay intestinal glucose absorption and inhibit gluconeogenesis...
  3. ncbi Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties
    Nari Yun
    School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi do 440 746, South Korea
    J Nutr Biochem 23:1249-55. 2012
    ..b>Chlorogenic acid (CGA), one of the most abundant polyphenols in the human diet, has been shown to exert potent anti-..
  4. ncbi Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid
    Michel David dos Santos
    University of Sao Paulo, Faculty of Pharmaceutical Sciences of Ribeirao Preto, Brazil
    Biol Pharm Bull 29:2236-40. 2006
    ..b>Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet...
  5. ncbi In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid
    Yuki Sato
    Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Int J Pharm 403:136-8. 2011
    ..Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of caffeic acid and quinic acid...
  6. ncbi Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation
    Jianhua Shan
    Nanjing Normal University, Jiangsu, PR China
    Int Immunopharmacol 9:1042-8. 2009
    b>Chlorogenic acid (CGA) is a naturally occurring phenolic acid in human diet. Data obtained from in vivo and in vitro experiments demonstrate that CGA mostly presents anti-oxidant and anti-carcinogenic activities...
  7. ncbi Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice
    Seung Hwan Kwon
    Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    Eur J Pharmacol 649:210-7. 2010
    b>Chlorogenic acid is a major polyphenolic component of many plants and beverages, and is particularly abundant in coffee...
  8. ncbi Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice
    Ae Sim Cho
    Department of Nutrition Education, Graduate School of Education, Sunchon National University, Suncheon 540 742, Republic of Korea
    Food Chem Toxicol 48:937-43. 2010
    This study investigated the efficacy of chlorogenic acid on altering body fat in high-fat diet (37% calories from fat) induced-obese mice compared to caffeic acid. Caffeic acid or chlorogenic acid was supplemented with high-fat diet at 0...
  9. ncbi Antioxidant and DNA-protective activities of chlorogenic acid isomers
    Jian guo Xu
    College of Engineering, Shanxi Normal University, Linfen City, 041004, China
    J Agric Food Chem 60:11625-30. 2012
    b>Chlorogenic acid is a well-known antioxidant and has more isomers according to the difference in binding location and number of caffeic on quinic acid...
  10. ncbi On-line HPLC-DPPH screening method for evaluation of radical scavenging phenols extracted from apples (Malus domestica L.)
    Donata Bandoniene
    Institute of Food Chemistry and Technology, Graz University of Technology, Petersgasse 12, A 8010 Graz, Austria
    J Agric Food Chem 50:2482-7. 2002
    ..Comparison of the UV and DPPH radical quenching chromatograms with authentic compounds identified catechin, chlorogenic acid, caffeic acid, epicatechin, and phloridzin in the apple cultivars (Lobo, Golden Delicious, and Boskoop), and ..
  11. ncbi Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro
    Gui Feng Wang
    Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People s Republic of China
    Antiviral Res 83:186-90. 2009
    b>Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2...
  12. ncbi Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway
    Haitao Shi
    Department of Gastroenterology, Second Affiliated Hospital of Xi an Jiaotong University, No 157 Xiwu Road, Xi an, Shaanxi 710004, China
    Toxicology 303:107-14. 2013
    b>Chlorogenic acid (CGA) is a type of polyphenol with anti-inflammatory, antioxidant activities. Our previous studies showed CGA could efficiently inhibit carbon tetrachloride (CCl(4))-induced liver fibrosis in rats...
  13. ncbi The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension
    Takuya Watanabe
    Health Care Products Laboratories, Kao Corporation, Tokyo, Japan
    Clin Exp Hypertens 28:439-49. 2006
    ..There was no difference in body mass index and pulse rate between groups, nor were there any apparent side effects. Thus, CGA from GCE is effective in decreasing blood pressure and safe for patients with mild hypertension...
  14. ncbi Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on streptozotocin-nicotinamide-induced diabetic rats
    Krishnamoorthy Karthikesan
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India
    Gen Physiol Biophys 29:23-30. 2010
    We have shown that separate dose of tetrahydrocurcumin (THC) at a dose of 80 mg/kg body weight (b.w.) and chlorogenic acid (CGA) at a dose of 5 mg/kg b.w. exerts antidiabetic potential in streptozotocin (STZ) (45 mg/kg b.w...
  15. pmc Identification of chlorogenic acid as a resistance factor for thrips in chrysanthemum
    Kirsten A Leiss
    Research Group Plant Ecology, Institute of Biology, Leiden University, 2311 GP Leiden, The Netherlands
    Plant Physiol 150:1567-75. 2009
    ..Thrips-resistant chrysanthemums contained higher amounts of the phenylpropanoids chlorogenic acid and feruloyl quinic acid...
  16. ncbi Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid
    Rentian Feng
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 280:27888-95. 2005
    b>Chlorogenic acid, the ester of caffeic acid with quinic acid, is one of the most abundant polyphenols in the human diet. The antioxidant and anticarcinogenic properties of chlorogenic acid have been established in animal studies...
  17. ncbi Anti-human immunodeficiency virus activity of 3,4,5-tricaffeoylquinic acid in cultured cells of lettuce leaves
    Hirotoshi Tamura
    Department of Biochemistry and Food Science, Kagawa University, Miki cho, Japan
    Mol Nutr Food Res 50:396-400. 2006
    ..The intact plant produced chicoric acid (dicaffeoyl tartaric acid: L-CCA) as well as chlorogenic acid (3-caffeoylquinic acid: 3-CQA) as the major metabolites...
  18. ncbi [Study on allergenicity of chlorogenic acid in Qingkailing injection]
    Zhiguo Wang
    Experimental Research Center, China Academy of Chinese Medical Scinces, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 36:1870-3. 2011
    To observe the allergenicity of chlorogenic acid (CA) in Qingkailing injection.
  19. ncbi Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice
    Yuexin Xu
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, Nanjing 210046, China
    Inflamm Res 59:871-7. 2010
    To investigate the potential protective effects of chlorogenic acid (CGA) on acute liver injury caused by lipopolysaccharide (LPS) in mice.
  20. ncbi Efficient topical delivery of chlorogenic acid by an oil-in-water microemulsion to protect skin against UV-induced damage
    Shuji Kitagawa
    Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe, Japan
    Chem Pharm Bull (Tokyo) 59:793-6. 2011
    We examined the intradermal delivery of a hydrophilic polyphenol chlorogenic acid by in vitro study using excised guinea pig dorsal skin and Yucatan micropig skin...
  21. ncbi Chlorogenic acid protects mice against lipopolysaccharide-induced acute lung injury
    Xu Zhang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Rd, Nanjing, Jiangsu 210093, PR China
    Injury 41:746-52. 2010
    b>Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet. Our previous in vitro study demonstrates that CGA presents anti-inflammatory activities in RAW 264.7 cells...
  22. ncbi Chlorogenic acid attenuates adhesion molecules upregulation in IL-1beta-treated endothelial cells
    Weng Cheng Chang
    Graduate Institute of Medical Sciences, Chang Jung Christian University, Tainan, Taiwan
    Eur J Nutr 49:267-75. 2010
    ..b>Chlorogenic acid is a phenolic compound present in coffee, apples, pears, berries, almonds, artichokes, and aubergines...
  23. pmc Mast cell degranulation induced by chlorogenic acid
    Fang hua Huang
    National Drug Screening Center, China Pharmaceutical University, Nanjing, China
    Acta Pharmacol Sin 31:849-54. 2010
    To investigate the mechanism of chlorogenic acid (CA)-induced anaphylactoid reactions.
  24. ncbi Effect of roasting on the formation of chlorogenic acid lactones in coffee
    Adriana Farah
    Vanderbilt Institute for Coffee Studies, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Agric Food Chem 53:1505-13. 2005
    ..When roasting coffee, some of these are transformed into chlorogenic acid lactones (CGL). We have studied the formation of CGL during the roasting of coffee beans in Coffea arabica cv...
  25. ncbi A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:848-53. 2005
    ..production of the incretin hormone glucagon-like peptide-1 (GLP-1), possibly owing to an inhibitory effect of chlorogenic acid (CGA -- the chief polyphenol in coffee) on glucose absorption...
  26. ncbi Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet
    Chun Wai Wan
    Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, SAR, China
    Phytother Res 27:545-51. 2013
    ..In the present study, the hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density ..
  27. ncbi Chlorogenic acid and caffeic acid are absorbed in humans
    M R Olthof
    Division of Human Nutrition and Epidemiology, Wageningen University, 6700 EV Wageningen, The Netherlands margreet
    J Nutr 131:66-71. 2001
    b>Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee; daily intake in coffee drinkers is 0.5-1 g...
  28. ncbi Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial
    Aidilla Mubarak
    School of Medicine and Pharmacology, University of Western Australia, Australia
    J Agric Food Chem 60:9130-6. 2012
    ..Our aim was to investigate the acute effects of chlorogenic acid, an important dietary phenolic acid present in coffee (400 mg, equivalent to 2 cups of coffee), on nitric ..
  29. ncbi Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation
    Khang Wei Ong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Biochem Pharmacol 85:1341-51. 2013
    b>Chlorogenic acid (CGA) has been shown to stimulate glucose uptake in skeletal muscle through the activation of AMPK...
  30. ncbi Antibacterial activity and mechanism of action of chlorogenic acid
    Zaixiang Lou
    State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan Univ, Wuxi 214122, PR China
    J Food Sci 76:M398-403. 2011
    In this study, the antibacterial activity and mechanism of action of chlorogenic acid against bacteria were assessed...
  31. pmc Chlorogenic acid and rutin play a major role in the in vivo anti-diabetic activity of Morus alba leaf extract on type II diabetic rats
    Attila Hunyadi
    Institute of Pharmacognosy, University of Szeged, Szeged, Hungary
    PLoS ONE 7:e50619. 2012
    ..activity of an extract of mulberry leaves (MA), and to examine to what extent three major constituents, chlorogenic acid, rutin and isoquercitrin, might contribute to the observed activity...
  32. ncbi Genetic mapping of a caffeoyl-coenzyme A 3-O-methyltransferase gene in coffee trees. Impact on chlorogenic acid content
    C Campa
    IRD, BP 64501, 34394 Montpellier Cedex 5, France
    Theor Appl Genet 107:751-6. 2003
    ..Dewevrei and Coffea pseudozanguebariae. Offspring of this backcross were also evaluated for the chlorogenic acid content in their green beans. A 10% decrease was observed in backcross progenies that possess one C...
  33. ncbi Insulin receptor exon 11+/- is expressed in Zucker (fa/fa) rats, and chlorogenic acid modifies their plasma insulin and liver protein and DNA
    Delcy V Rodriguez de Sotillo
    Department of Chemistry, Minnesota State University, Mankato, 56001, USA
    J Nutr Biochem 17:63-71. 2006
    In vivo studies confirmed that chlorogenic acid (CGA) improved glucose tolerance and mineral pool distribution in obese Zucker (fa/fa) rats. We found a significant decrease (P<...
  34. ncbi Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid
    Hye Rin Kim
    Department of Biology, Changwon National University, 9, Sarim dong, Changwon, Kyungnam 641 773, South Korea
    Int Immunopharmacol 10:1242-8. 2010
    ..b>Chlorogenic acid (CGA), an ester of caffeic acid with quinic acid, is one of the most abundant polyphenol compounds in various ..
  35. ncbi Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agents
    K Karthikesan
    Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, Tamilnadu, India
    Chem Biol Interact 188:643-50. 2010
    ..The present study was carried out to evaluate the effects of tetrahydrocurcumin (THC) and chlorogenic acid (CGA) alone and in combination on alterations in lipids, lipoproteins and enzymes involved in lipid ..
  36. ncbi Espresso coffees, caffeine and chlorogenic acid intake: potential health implications
    Thomas W M Crozier
    School of Medicine, College of Medical, Veterinary and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Food Funct 3:30-3. 2012
    ..New data are needed to provide informative labelling, with attention to bean variety, preparation, and barista methods...
  37. ncbi Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats
    A W Herling
    Hoechst Marion Roussel Deutschland GmbH, H 821 Pharmacology, 65926, Frankfurt am Main, Germany
    Eur J Pharmacol 386:75-82. 1999
    ..5-b]pyridin-1-yl-3-phenyl-acryloyloxy)-cyclohexanecarboxylic acid), a derivative of chlorogenic acid, specifically inhibits the glucose-6-phosphate translocating component T1 of the glucose-6-phosphatase system...
  38. pmc The anti-angiogenic effect of chlorogenic acid on choroidal neovascularization
    Cinoo Kim
    Department of Ophthalmology, Incheon Medical Center, Incheon, Korea
    Korean J Ophthalmol 24:163-8. 2010
    To evaluate the inhibitory effect of chlorogenic acid on laser-induced choroidal neovascularization (CNV) in a rat model.
  39. ncbi Antimicrobial activity of Tunisian quince (Cydonia oblonga Miller) pulp and peel polyphenolic extracts
    Sami Fattouch
    Biological Engineering Laboratory, National Institute of Applied Sciences and Technology, Tunis 1080, Tunisia
    J Agric Food Chem 55:963-9. 2007
    ..b>Chlorogenic acid (5-O-caffeoylquinic acid) was the most abundant phenolic compound in the pulp (37%), whereas rutin (quercetin ..
  40. ncbi Simultaneous quantification of seven bioactive components in Caulis Lonicerae Japonicae by high performance liquid chromatography
    Zheng Ming Qian
    Key Laboratory of Modern Chinese Medicines, Ministry of Education, China Pharmaceutical University, Nanjing 210009, People s Republic of China
    Biomed Chromatogr 21:649-54. 2007
    This study presents a new HPLC method for the simultaneous determination of seven major components, namely chlorogenic acid, caffeic acid, loganin, sweroside, secoxyloganin, rutin and luteolin 7-O-glucoside in Caulis Lonicerae Japonicae, ..
  41. ncbi Chlorogenic acid, a polyphenolic compound, treats mice with septic arthritis caused by Candida albicans
    Jue Hee Lee
    Department of ImmunoMicrobiology, College of Pharmacy Dongduk Women s University, 23 1 Wolgok Dong, Seongbuk gu, Seoul 136 714, Republic of Korea
    Int Immunopharmacol 8:1681-5. 2008
    ..In this present study, we determined the effect of chlorogenic acid (CRA), a polyphenolic compound, on septic arthritis caused by Candida albicans, a major etiological agent ..
  42. ncbi Application of preparative high-speed counter-current chromatography for separation of chlorogenic acid from Flos Lonicerae
    Hai tao Lu
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Chromatogr A 1026:185-90. 2004
    b>Chlorogenic acid, an ester formed between caffeic acid and quinic acid, is a major phenolic compound in the traditional Chinese medicinal herb Flos Lonicerae...
  43. ncbi Modulating effects of chlorogenic acid on lipids and glucose metabolism and expression of hepatic peroxisome proliferator-activated receptor-alpha in golden hamsters fed on high fat diet
    Shu Yuan Li
    Division of Nutrition and Biochemistry, Institute of Sports Medicine, Third Hospital, Peking University, Beijing 100191, China
    Biomed Environ Sci 22:122-9. 2009
    To examine the effects of chlorogenic acid (CGA) on lipid and glucose metabolism under a high dietary fat burden and to explore the possible role of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in these effects.
  44. ncbi Application of ultrasonic technique for extracting chlorogenic acid from Eucommia ulmodies Oliv. (E. ulmodies)
    Hui Li
    State Key Laboratory of Chemo Biological Sensing and Chemometrics, Hunan University, Changsha 410082, PR China
    Ultrason Sonochem 12:295-300. 2005
    An ultrasonic method for the extraction of chlorogenic acid from fresh leaves of Eucommia ulmodies Oliv. was investigated and optimized...
  45. pmc Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance
    Aimee E van Dijk
    Department of Health Sciences, EMGO Institute for Health and Care Research, VU University Amsterdam, The Netherlands
    Diabetes Care 32:1023-5. 2009
    Coffee consumption has been associated with lower risk of type 2 diabetes. We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.
  46. ncbi Engineering plants with increased levels of the antioxidant chlorogenic acid
    Ricarda Niggeweg
    John Innes Centre, Norwich Research Park, Colney, Norwich, NR4 7UH, UK
    Nat Biotechnol 22:746-54. 2004
    ..Phenolics are the most widespread dietary antioxidants, and among these, chlorogenic acid (CGA) accumulates to high levels in some crop plants...
  47. pmc Isolation and functional characterization of a cDNA coding a hydroxycinnamoyltransferase involved in phenylpropanoid biosynthesis in Cynara cardunculus L
    Cinzia Comino
    Di Va P R A Plant Genetics and Breeding, University of Torino 10095, Grugliasco Turin, Italy
    BMC Plant Biol 7:14. 2007
    ..phenolics are the di-caffeoylquinic acids (such as cynarin), which are largely restricted to Cynara species, along with their precursor, chlorogenic acid (CGA). The scope of this study is to better understand CGA synthesis in this plant.
  48. ncbi Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans
    Margreet R Olthof
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
    J Nutr 133:1806-14. 2003
    ..The aim of this study was to identify and quantify the phenolic acid metabolites of chlorogenic acid (major phenol in coffee), quercetin-3-rutinoside (major flavonol in tea) and black tea phenols in humans, and ..
  49. pmc Novel hydroxycinnamoyl-coenzyme A quinate transferase genes from artichoke are involved in the synthesis of chlorogenic acid
    Gabriella Sonnante
    Institute of Plant Genetics, National Research Council, 70126 Bari, Italy
    Plant Physiol 153:1224-38. 2010
    ..extracts have high antioxidant capacity, due primarily to flavonoids and phenolic acids, particularly chlorogenic acid (5-caffeoylquinic acid [CGA]), dicaffeoylquinic acids, and caffeic acid, which are abundant in flower bracts ..
  50. ncbi Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols
    Won Jun Lee
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
    Carcinogenesis 27:269-77. 2006
    We studied the modulating effects of caffeic acid and chlorogenic acid (two common coffee polyphenols) on the in vitro methylation of synthetic DNA substrates and also on the methylation status of the promoter region of a representative ..
  51. ncbi Molecular mechanisms of (-)-epicatechin and chlorogenic acid on the regulation of the apoptotic and survival/proliferation pathways in a human hepatoma cell line
    Ana Belén Granado-Serrano
    Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas, Jose Antonio Novais 10, Ciudad Universitaria, 28040 Madrid, Spain
    J Agric Food Chem 55:2020-7. 2007
    ..This work was aimed at studying the effect of (-)-epicatechin (EC) and chlorogenic acid (CGA) on the regulation of apoptotic and survival/proliferation pathways in a human hepatoma cell line (HepG2)..
  52. ncbi Identification and antioxidant activity of novel chlorogenic acid derivatives from bamboo (Phyllostachys edulis)
    M H Kweon
    Graduate School of Biotechnology, Korea University, 5-1 ka Anam-dong, Sungbuk-ku, Seoul 136-701, Korea
    J Agric Food Chem 49:4646-55. 2001
    ..fractionation of the extract led to the isolation and characterization of three structural isomeric chlorogenic acid derivatives: 3-O-(3'-methylcaffeoyl)quinic acid (1), 5-O-caffeoyl-4-methylquinic acid (2), and 3-O-caffeoyl-1-..
  53. ncbi The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines
    Teresa Krakauer
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Immunopharmacol Immunotoxicol 24:113-9. 2002
    Proinflammatory cytokines mediate the toxic effect of staphylococcal exotoxins (SE). Chlorogenic acid, a plant polyphenol, inhibited SE-induced T-cell proliferation (by 98%) and production of interleukin 1beta, tumor necrosis factor, ..
  54. ncbi Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes
    Pranav Kumar Prabhakar
    Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, India
    Phytomedicine 16:1119-26. 2009
    The present study analyses the effect of two plant phenolic compounds, namely chlorogenic acid and ferulic acid, and a plant alkaloid, berberine, alone and also in combination with two commercial oral hypoglycemic drugs (OHD), namely ..
  55. ncbi Chlorogenic acids from green coffee extract are highly bioavailable in humans
    Adriana Farah
    Departamento de Bioquimica, Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica, Universidade Federal do Rio de Janeiro, Ilha do Fundao, RJ, Brazil
    J Nutr 138:2309-15. 2008
    ..5 +/- 10.6% urinary recovery of the ingested cinnamic and quinic acid moiteties. This study shows that the major CGA compounds present in green coffee are highly absorbed and metabolized in humans...
  56. ncbi Hierarchical scheme for LC-MSn identification of chlorogenic acids
    Michael N Clifford
    Centre for Nutrition and Food Safety, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
    J Agric Food Chem 51:2900-11. 2003
    ..The hierarchical key permitted specific structures to be assigned to each of the six isomers. These assignments are internally consistent and consistent with the limited data previously available...
  57. pmc Metabolic pathways in tropical dicotyledonous albuminous seeds: Coffea arabica as a case study
    Thierry Joet
    IRD, UMR DIA PC, Pole de protection des plantes, Saint Pierre, La Reunion, France
    New Phytol 182:146-62. 2009
    ..traits of the coffee endosperm, such as its unusual fatty acid composition, remarkable accumulation of chlorogenic acid and cell wall polysaccharides...
  58. ncbi Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells
    Haitao Shi
    Department of Gastroenterology, Second Affiliate Hospital of Xi an Jiao Tong University, No 157 Xiwu Road, Xi an 710004, Shaanxi, China
    Inflamm Res 62:581-7. 2013
    This study was aimed at investigating the effect of chlorogenic acid (CGA) on lipopolysaccharide (LPS)-induced proinflammatory signaling in hepatic stellate cells (HSCs).
  59. ncbi Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats
    Hongyang Shi
    Department of Gastroenterology, Second Affiliate Hospital of Xian Jiao Tong University, Xian 710004, China
    Eur J Pharmacol 623:119-24. 2009
    This study examined the effects of chlorogenic acid (CGA) on liver fibrosis induced by carbon tetrachloride (CCl(4)) and explored the possible mechanisms of action...
  60. pmc Effect of chlorogenic acid on antioxidant activity of Flos Lonicerae extracts
    Lan Wu
    Department of Horticulture, Beijing Vocational College of Agriculture, Beijing 102442, China
    J Zhejiang Univ Sci B 8:673-9. 2007
    ..b>Chlorogenic acid, a major component of Flos Lonicerae, is identified and further purified from 70% ethanolic extract with high ..
  61. ncbi Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees
    Yi Fang Chu
    Kraft Foods Research and Nutrition, 801 Waukegan Road, Glenview, Illinois 60025, USA
    J Agric Food Chem 57:9801-8. 2009
    ..Analysis of coffee phenolic compounds revealed that roasted coffees contained high levels of chlorogenic acid lactones (CGLs); a significant correlation between CGLs and neuroprotective efficacy was observed (R(2) = 0...
  62. pmc The isolation and mapping of a novel hydroxycinnamoyltransferase in the globe artichoke chlorogenic acid pathway
    Cinzia Comino
    DiVaPRA Plant Genetics and Breeding, University of Torino, Grugliasco Torino, Italy
    BMC Plant Biol 9:30. 2009
    ..have significant pharmaceutical properties, which mainly result from their high content of polyphenolic compounds such as monocaffeoylquinic and dicaffeoylquinic acid (DCQ), and a range of flavonoid compounds...
  63. ncbi Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes
    Leelavinothan Pari
    Faculty of Science, Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002 Tamilnadu, India
    Mol Cell Biochem 341:109-17. 2010
    The present study evaluates the combined effect of tetrahydrocurcumin and chlorogenic acid on oxidative stress in streptozotocin-nicotinamide-induced diabetic rats. Rats were rendered diabetic by a single intraperitoneal injection (i...
  64. ncbi Coffee polyphenol caffeic acid but not chlorogenic acid increases 5'AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscle
    Satoshi Tsuda
    Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606 8501, Japan
    J Nutr Biochem 23:1403-9. 2012
    b>Chlorogenic acid is an ester of caffeic and quinic acids, and is one of the most widely consumed polyphenols because it is abundant in foods, especially coffee...
  65. ncbi Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo
    Ute Boettler
    University of Vienna, Department of Food Chemistry and Toxicology, Vienna, Austria
    Mol Nutr Food Res 55:798-802. 2011
    ..Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo...
  66. ncbi Selenium increases chlorogenic acid, chlorophyll and carotenoids of Lycium chinense leaves
    Jing Z Dong
    Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, School of Biological Science and Technology, Hubei University for Nationalities, Enshi, 445000, China
    J Sci Food Agric 93:310-5. 2013
    ..Selenium has been reported to increase some components of plants. In this study, the composition of polyphenols of L. chinense leaves were analysed, and the effects of selenium on the polyphenols and other components were studied...
  67. ncbi Development of free radical products during the greening reaction of caffeic acid esters (or chlorogenic acid) and a primary amino compound
    M Namiki
    Department of Fermentation Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan
    Biosci Biotechnol Biochem 65:2131-6. 2001
    ..A formation mechanism of the green pigment and related products involving these free radical products is proposed...
  68. ncbi Chlorogenic acid and maize ear rot resistance: a dynamic study investigating Fusarium graminearum development, deoxynivalenol production, and phenolic acid accumulation
    Vessela Atanasova-Penichon
    Institut National de la Recherche Agronomique, Villenave D Ornon, France
    Mol Plant Microbe Interact 25:1605-16. 2012
    ..We found that chlorogenic acid is more abundant in the moderately resistant variety, with levels spiking in the earliest kernel stages ..
  69. ncbi Transepithelial transport of chlorogenic acid, caffeic acid, and their colonic metabolites in intestinal caco-2 cell monolayers
    Yutaka Konishi
    Applied Bioresearch Center, Research and Development Department, Kirin Brewery Company, Ltd, 3 Miyaharacho, Takasaki shi, Gunma 370 1295, Japan
    J Agric Food Chem 52:2518-26. 2004
    ..Thus, the absorption efficiency of caffeic acid was greater than that of chlorogenic acid. Polarized transport of caffeic acid was inhibited by substrates of MCT such as benzoic and acetic acids...
  70. ncbi Chlorogenic acid UVA–UVB photostability
    Diogo P Rivelli
    Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Brasil
    Photochem Photobiol 86:1005-7. 2010
    b>Chlorogenic acid is a natural potent antioxidant. It can be used in cosmetics formulations, but for this purpose its photochemical stability should be determined to ensure that the compound will not be degraded after UV radiation exposure...
  71. ncbi Inhibitory effects of chlorogenic acid on aldose reductase activity in vitro and cataractogenesis in galactose-fed rats
    Chan Sik Kim
    Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon, Korea
    Arch Pharm Res 34:847-52. 2011
    b>Chlorogenic acid (5-O-caffeoylquinic acid, CA), a phenolic compound found ubiquitously in plants, has antidiabetic effect in diabetic animal models. In this study, we investigated the inhibitory effect of CA on diabetic cataractogenesis...
  72. ncbi Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia
    Kyungjin Lee
    College of Oriental Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Eur J Pharmacol 689:89-95. 2012
    b>Chlorogenic acid (CGA) has been reported to have various beneficial effects on the cardiovascular and central nervous systems...
  73. ncbi Cloning and characterization of a cDNA coding a hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase involved in chlorogenic acid biosynthesis in Lonicera japonica
    Xiaoxiao Peng
    Department of Biopharmaceutics, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
    Planta Med 76:1921-6. 2010
    ..japonica has potent and significant effects is that it contains various active components, especially chlorogenic acid (CGA)...
  74. ncbi Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats
    Sophie Lafay
    Unite de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    Br J Nutr 96:39-46. 2006
    The absorption and metabolism in the small intestine of chlorogenic acid (5-O-caffeoylquinic acid), the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to determine whether chlorogenic acid is ..
  75. ncbi The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures
    W Mullen
    College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    J Agric Food Chem 59:3754-62. 2011
    ..Antioxidant activity in whole coffee fruit extracts was up to 25-fold higher than in powders dependent upon the radical. Total antioxidant activity of samples displayed strong correlation to CGA content...
  76. ncbi Effect of chlorogenic acid on mast cell-dependent anaphylactic reaction
    Hui Di Qin
    School of Pharmaceutical Sciences, Shandong University, 44 Wen Hua Xi Road, Jinan, 250012, PR China
    Int Immunopharmacol 10:1135-41. 2010
    b>Chlorogenic acid (CGA), a naturally occurring polyphenol compound, has a number of biological activities. However, roles of CGA in the mast cell-dependent anaphylactic reaction have not been fully examined...
  77. ncbi Novel electrochemical sensor for the selective recognition of chlorogenic acid
    Wilney de Jesus Rodrigues Santos
    Institute of Chemistry, University of Campinas UNICAMP, Campinas, Brazil
    Anal Chim Acta 695:44-50. 2011
    ..a novel sensitive molecularly imprinted electrochemical sensor was constructed for the selective detection of chlorogenic acid (CGA) by deposition of a molecularly imprinted siloxane (MIS) film, prepared by sol-gel process, onto Au bare ..
  78. ncbi Effects of chlorogenic acid, an active compound activating calcineurin, purified from Flos Lonicerae on macrophage
    He zhen Wu
    Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing 100875, China
    Acta Pharmacol Sin 25:1685-9. 2004
    To investigate the activation of chlorogenic acid (CHA) purified from Flos Lonicerae to calcineurin and its effects on macrophage functions in vivo and in vitro.
  79. ncbi [Does coffee protect against type 2 diabetes?]
    D Legrand
    Service de Diabetologie, Nutrition et Maladies Metaboliques, Département de Médecine et Unité de Pharmacologie clinique, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 62:554-9. 2007
    ..attributed exclusively to caffeine, but rather that it should be explained by other components, most probably chlorogenic acid and/or various anti-oxidants...
  80. ncbi Investigation of the inclusion behavior of chlorogenic acid with hydroxypropyl-β-cyclodextrin
    Jianbin Chao
    Research Institute of Applied Chemistry, Shanxi University, Taiyuan, PR China
    Int J Biol Macromol 50:277-82. 2012
    The inclusion complexation behavior of chlorogenic acid (CGA) with the hydroxypropyl-β-cyclodextrin (HP-β-CD) was investigated in both solution and the solid state by UV-vis and fluorescence spectroscopy, infrared spectroscopy (IR), NMR ..
  81. ncbi Light-induced root hair formation in lettuce (Lactuca sativa L. cv. Grand Rapids) roots at low pH is brought by chlorogenic acid synthesis and sugar
    Megumi Narukawa
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278 8510, Japan
    J Plant Res 123:789-99. 2010
    Previously, we reported that chlorogenic acid (CGA) facilitated root hair formation at pH 4.0 in lettuce (Lactuca sativa L. cv. Grand Rapids). Light was essential for this process...
  82. ncbi Synthesis of chlorogenic acid derivatives with promising antifungal activity
    Chao Mei Ma
    School of Pharmacy, Memorial University of Newfoundland, St John s, NL, Canada
    Bioorg Med Chem 15:6830-3. 2007
    Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids...
  83. ncbi Genotype, location, and year influence antioxidant activity, carotenoid content, phenolic content, and composition in specialty potatoes
    Lavanya Reddivari
    Department of Horticultural Sciences, 2133 TAMU, Texas A and M University, College Station, Texas 77843 2133, USA
    J Agric Food Chem 55:8073-9. 2007
    ..Phenolic composition differed significantly among genotypes and between locations. The AOA, TP, and chlorogenic acid content were significantly correlated with one another...
  84. ncbi A gradient HPLC method for the quality control of chlorogenic acid, linarin and luteolin in Flos Chrysanthemi Indici suppository
    Qunlin Zhang
    School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, PR China
    J Pharm Biomed Anal 43:753-7. 2007
    ..high-performance liquid chromatographic (HPLC) method was applied to the simultaneous determination of chlorogenic acid, linarin and luteolin in Flos Chrysanthemi Indici suppository...
  85. ncbi Preventive effect of chlorogenic acid on lens opacity and cytotoxicity in human lens epithelial cells
    Young Sook Kim
    Diabetic Complications Research Center, Division of Traditional Korean Medicine TKM Integrated Research, Korea Institute of Oriental Medicine KIOM, Daejeon, Korea
    Biol Pharm Bull 34:925-8. 2011
    The present study reveals the pharmacological effect of chlorogenic acid, a major phenolic compound in plants, food, and coffee, on diabetic cataracts...
  86. ncbi Chlorogenic acid protects MSCs against oxidative stress by altering FOXO family genes and activating intrinsic pathway
    Shiyong Li
    Key Laboratory of Molecular Medicine, Second Affiliated Hospital of Nanchang University, Nanchang City, China
    Eur J Pharmacol 674:65-72. 2012
    b>Chlorogenic acid as an antioxidant exists widely in edible and medicinal plants, and can protect cell against apoptosis induced by oxidative stress. However, its molecular mechanisms remain largely unknown...
  87. ncbi Inhibitory activity of chlorogenic acid on enzymes involved in the fatty acid synthesis in animals and bacteria
    Bing Hui Li
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing, PR China
    IUBMB Life 58:39-46. 2006
    It was found that chlorogenic acid inhibited in vitro animal fatty acid synthase (FAS I) and the ss-ketoacyl-ACP reductase (FabG) from Escherichia coli in a concentration-dependent manner with respective IC50 of 94.8 and 88.1 microM...
  88. ncbi A high performance liquid chromatography method for the simultaneous determination of arctiin, chlorogenic acid and glycyrrhizin in a Chinese proprietary medicine
    Xudong Yuan
    Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA
    J Pharm Biomed Anal 39:697-704. 2005
    ..performance liquid chromatography (HPLC) method was developed for the simultaneous determination of arctiin, chlorogenic acid and glycyrrhizin in the tablets of a Chinese proprietary medicine named, "Yin Qiao Jie Du Pian"...
  89. ncbi Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine
    Kelly L Johnston
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdom
    Am J Clin Nutr 78:728-33. 2003
    ..Accumulating evidence suggests that certain dietary polyphenols have biological effects in the small intestine that alter the pattern of glucose uptake. Their effects, however, on glucose tolerance in humans are unknown...
  90. ncbi Evaluation of the immunosensitizing potential of chlorogenic acid using a popliteal lymph node assay in BALB/c mice
    Zhaohua Liu
    Department of Pathology, Shandong University School of Medicine, 44 Wen Hua Xi Road, Jinan, Shandong 250012, PR China
    Food Chem Toxicol 48:1059-65. 2010
    It has yet to be established whether chlorogenic acid (CGA), a common xenobiotic with potential exposure risk to humans, is associated with immune-mediated hypersensitivity reactions (HRs)...
  91. ncbi Characterization of antioxidant activity of extracts from Flos Lonicerae
    Wu Lan
    College of Food Science and Biotechnology, Tianjin University of Science and Technology, 1038 Dagu Nanlu, Hexi District, Tianjin, China
    Drug Dev Ind Pharm 33:841-7. 2007
    ..b>Chlorogenic acid, a major component of Flos Lonicerae, is identified and further purified from 70% ethanolic extract with HPLC ..
  92. ncbi Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats
    Marie Paule Gonthier
    Unité des Maladies Métaboliques et Micronutriments, INRA Theix, 63122 Saint Genes Champanelle, France
    J Nutr 133:1853-9. 2003
    b>Chlorogenic acid, the ester of caffeic acid with quinic acid, is one of the most abundant polyphenols in the human diet with coffee, fruits and vegetables as its major sources...
  93. ncbi Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H₂O₂-induced apoptosis in primary cortical neurons
    Jiyoung Kim
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151 742, Republic of Korea
    Neurochem Int 60:466-74. 2012
    ..the protective effects of caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid (5-O-caffeoylquinic acid), which is present in both caffeinated and decaffeinated coffee, against oxidative ..
  94. ncbi [Comprehensive research and evaluation of chlorogenic acid allergy]
    Xiaodong Wu
    West China School of Pharmacy of Sichuan University, Chengdu 610041, China
    Zhongguo Zhong Yao Za Zhi 35:3357-61. 2010
    The non-allergy of chlorogenic acid was demonstrated by the study result of allergy with different purity of chlorogenic acid and comprehensive analysis of literature.
  95. ncbi Effects of chlorogenic acid on neutrophil locomotion functions in response to inflammatory stimulus
    C B Hebeda
    Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Ethnopharmacol 135:261-9. 2011
    Species of Lychnophora are used in Brazilian folk medicine as analgesic and anti-inflammatory agents. Chlorogenic acid (CGA) and their analogues are important components of polar extracts of these species, as well in several European and ..
  96. ncbi Simultaneous analysis of theanine, chlorogenic acid, purine alkaloids and catechins in tea samples with the help of multi-dimension information of on-line high performance liquid chromatography/electrospray-mass spectrometry
    Xiaolan Zhu
    Chemistry and Chemical Engineering, Chemical Research Institute, Human Normal University, Changsha 410081, PR China
    J Pharm Biomed Anal 34:695-704. 2004
    ..Theanine, chlorogenic acid, purine alkaloids and catechins were identified with authentic standard compounds and with MS-spectra...
  97. ncbi Oxidative damage to DNA by 1,10-phenanthroline/L: -threonine copper (II) complexes with chlorogenic acid
    Yong Wang
    College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo Biosensing, Anhui Normal University, Wuhu 241000, People s Republic of China
    Biometals 23:265-73. 2010
    The oxidative DNA damage by copper (II) complexes in the presence of chlorogenic acid was explored using agarose gel electrophoresis...
  98. pmc Gene overexpression and biochemical characterization of the biotechnologically relevant chlorogenic acid hydrolase from Aspergillus niger
    Isabelle Benoit
    UMR 1163 INRA Université de Provence de Biotechnologie des Champignons Filamenteux, IFR IBAIM, Universités de Provence et de la Méditerranée, ESIL, 163 Avenue de Luminy, Case Postale 925, 13288 Marseille Cedex 09, France
    Appl Environ Microbiol 73:5624-32. 2007
    The full-length gene that encodes the chlorogenic acid hydrolase from Aspergillus niger CIRM BRFM 131 was cloned by PCR based on the genome of the strain A. niger CBS 513.88...
  99. ncbi Characterization of inhibitors of postprandial hyperglycemia from the leaves of Nerium indicum
    Akiko Ishikawa
    Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:166-73. 2007
    ..analyses established that the chemical structures of these compounds are 3-O-caffeoylquinic acid (chlorogenic acid) and its structural isomer, 5-O-caffeoylquinic acid...
  100. ncbi Chemical kinetic behavior of chlorogenic acid in protecting erythrocyte and DNA against radical-induced oxidation
    You Zhi Tang
    Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun, China
    J Agric Food Chem 56:11025-9. 2008
    As an abundant ingredient in coffee, chlorogenic acid (CGA) is a well-known antioxidant...
  101. ncbi Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells
    Gautam Bandyopadhyay
    Division of Immunology, Indian Institute of Chemical Biology, 4, Raja S C Mullick Rd, Kolkata, India
    Blood 104:2514-22. 2004
    We report that chlorogenic acid (Chl) induces apoptosis of several Bcr-Abl-positive chronic myelogenous leukemia (CML) cell lines and primary cells from CML patients in vitro and destroys Bcr-Abl-positive K562 cells in vivo...

Research Grants8

  1. Preventive of Bile Acid-Induced Colonic Oxidative DNA Damage
    Claire Margaret Payne; Fiscal Year: 2010
    ..with the deleterious effects of DOC and include parthenolide, an NF-=B inhibitor, organic selenium compounds, chlorogenic acid and novel antioxidants that target mitochondria (e.g. MitoQ-ubiquinol)...
  2. Phenylpropanoid Analogs to Treat Stroke
    Paul A Lapchak; Fiscal Year: 2012
    ..vivo stroke models suggesting that the phenylpropanoid or polyphenol family of compounds, which includes (1) Chlorogenic acid;(2) Fisetin;and (3) Baicalein, may be useful to treat stroke...
  3. Antiviral/Antitumor Roles of Ganoderma Lucidum Spores
    Rui Liu; Fiscal Year: 2005
    ....
  4. Selective Induction of Estrogen Conjugative Metabolism
    Bao Ting Zhu; Fiscal Year: 2006
    ..These studies will also provide examinations of the important roles of bioactive estrogen metabolites (e.g., 4-OH-E2 and 16alpha-OH-E2) in estrogen-induced cancers. ..
  5. 2-METHOXYESTRADIOL & HORMONAL CANCER
    Bao Ting Zhu; Fiscal Year: 2006
    ..The results will also provide novel mechanistic understanding for the biological actions of 2-MeO-E2. ..
  6. Effect of digestion on the cancer chemopreventative activity of tea catechins
    Mario Ferruzzi; Fiscal Year: 2007
    ..Discovery of tea compounds which hold ultimate biological significance will enable future experimental strategies for specific tea catechin forms that positively affect cancer risk and outcomes. [unreadable] [unreadable] [unreadable]..
  7. Dietary Polyphenols Are Consequential Epigenetic Modulators of Gene Expression
    BAOTING ZHU; Fiscal Year: 2009
    ..It is expected that the outcomes of the proposed studies will have direct clinical utility in the near future and far-reaching human health implications. ..
  8. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..