caffeic acids

Summary

Summary: A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.

Top Publications

  1. ncbi Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid)
    Ilhami Gulcin
    Faculty of Arts and Sciences, Department of Chemistry, Ataturk University, TR 25240 Erzurum, Turkey
    Toxicology 217:213-20. 2006
  2. ncbi Caffeic acid phenethyl ester (CAPE) exhibits significant potential as an antidiabetic and liver-protective agent in streptozotocin-induced diabetic rats
    Sefa Celik
    Department of Biochemistry, Faculty of Medicine, Afyon Kocatepe University, Ali Cetinkaya Campus, Afyonkarahisar, Turkey
    Pharmacol Res 60:270-6. 2009
  3. ncbi Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells
    Masahiko Watabe
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo 173 8605, USA
    J Biol Chem 279:6017-26. 2004
  4. ncbi The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia/reperfusion injury in rabbits
    A Ilhan
    Department of Neurology, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey
    Eur J Cardiothorac Surg 16:458-63. 1999
  5. ncbi Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells
    Miao Fen Chen
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Chia Yi, Taiwan
    J Radiat Res 45:253-60. 2004
  6. ncbi Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells
    Yean Jang Lee
    Department of Chemistry, National Changhua University of Education, Changhua, Taiwan, ROC
    Biochem Pharmacol 66:2281-9. 2003
  7. ncbi Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling
    Debing Xiang
    Cancer Center, Daping Hospital and Institute of Surgery, Third Military Medical University, Chongqing, PRC
    Anticancer Drugs 17:753-62. 2006
  8. ncbi Apoptotic effect of caffeic acid phenethyl ester and its ester and amide analogues in human cervical cancer ME180 cells
    Mei Whey Hung
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
    Anticancer Res 23:4773-80. 2003
  9. ncbi Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice
    Jae Hyun Park
    Immunotoxicology Division, Department of Toxicology, National Institute of Toxicological Research, KFDA, Nokbun dong, Eunpyung Gu, Seoul 122 704, South Korea
    Int Immunopharmacol 4:429-36. 2004
  10. ncbi FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy
    Yuan Zhang
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Australia
    Eur J Heart Fail 14:549-62. 2012

Research Grants

  1. MACROPHAGE ACTIVATION AND LIPOPROTEIN METABOLISM
    Maria Lopes Virella; Fiscal Year: 2001
  2. Phenotypes of HIV-1 Integrases
    William Robinson; Fiscal Year: 2009
  3. AMYGDALA PLASTICITY IN PAIN
    ROBERT GEREAU; Fiscal Year: 2008
  4. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2008
  5. Midwest Regional Pain Interest Group Meeting
    ROBERT GEREAU; Fiscal Year: 2007
  6. 2-METHOXYESTRADIOL & HORMONAL CANCER
    Bao Ting Zhu; Fiscal Year: 2006
  7. Selective Induction of Estrogen Conjugative Metabolism
    Bao Ting Zhu; Fiscal Year: 2006
  8. FUNCTION AND MODULATION OF METABOTROPIC GLU RECEPTOR 5
    ROBERT GEREAU; Fiscal Year: 2003
  9. Defining an HIV Integrase Inhibitor Binding Pocket
    William Robinson; Fiscal Year: 2004
  10. Dietary Polyphenols Are Consequential Epigenetic Modulators of Gene Expression
    BAOTING ZHU; Fiscal Year: 2009

Detail Information

Publications246 found, 100 shown here

  1. ncbi Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid)
    Ilhami Gulcin
    Faculty of Arts and Sciences, Department of Chemistry, Ataturk University, TR 25240 Erzurum, Turkey
    Toxicology 217:213-20. 2006
    ..In addition, caffeic acid is an effective ABTS(+) scavenging, DPPH scavenging, superoxide anion radical scavenging, total reducing power and metal chelating on ferrous ions activities...
  2. ncbi Caffeic acid phenethyl ester (CAPE) exhibits significant potential as an antidiabetic and liver-protective agent in streptozotocin-induced diabetic rats
    Sefa Celik
    Department of Biochemistry, Faculty of Medicine, Afyon Kocatepe University, Ali Cetinkaya Campus, Afyonkarahisar, Turkey
    Pharmacol Res 60:270-6. 2009
    ..CAPE also has the ability to decrease the harmful effects of diabetes on the liver of rats...
  3. ncbi Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells
    Masahiko Watabe
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo 173 8605, USA
    J Biol Chem 279:6017-26. 2004
    ..Our findings demonstrate that NFkappaB inhibition is sufficient to induce apoptosis and that Fas activation plays a role in NFkappaB inhibition-induced apoptosis in MCF-7 cells...
  4. ncbi The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia/reperfusion injury in rabbits
    A Ilhan
    Department of Neurology, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey
    Eur J Cardiothorac Surg 16:458-63. 1999
    ..Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant properties. This experimental study was designed to determine the effect of CAPE on ischemia-reperfusion of spinal cord in rabbits...
  5. ncbi Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells
    Miao Fen Chen
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Chia Yi, Taiwan
    J Radiat Res 45:253-60. 2004
    ..Taken together, our results suggest that the effects of CAPE on differential cytotoxicity, apoptosis, and radiosensitization are associated with glutathione depletion that occurred shortly after treatments...
  6. ncbi Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells
    Yean Jang Lee
    Department of Chemistry, National Changhua University of Education, Changhua, Taiwan, ROC
    Biochem Pharmacol 66:2281-9. 2003
    ..The resultant data suggest that p38 MAPK mediated the CAPE-induced p53-dependent apoptosis in C6 glioma cells...
  7. ncbi Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling
    Debing Xiang
    Cancer Center, Daping Hospital and Institute of Surgery, Third Military Medical University, Chongqing, PRC
    Anticancer Drugs 17:753-62. 2006
    ....
  8. ncbi Apoptotic effect of caffeic acid phenethyl ester and its ester and amide analogues in human cervical cancer ME180 cells
    Mei Whey Hung
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
    Anticancer Res 23:4773-80. 2003
    ..The activities of CAPE and its novel synthetic derivatives, caffeic acid octyl ester (CAO) and 1-octyl caffeamide (CAN-8), were investigated in this study...
  9. ncbi Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice
    Jae Hyun Park
    Immunotoxicology Division, Department of Toxicology, National Institute of Toxicological Research, KFDA, Nokbun dong, Eunpyung Gu, Seoul 122 704, South Korea
    Int Immunopharmacol 4:429-36. 2004
    ..Likewise, the cytokine, IL-2, IL-4 and IFN-gamma were significantly increased at the dose of 20 mg/kg CAPE group. These results suggest that CAPE could have immunomodulatory effects in vivo...
  10. ncbi FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy
    Yuan Zhang
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Australia
    Eur J Heart Fail 14:549-62. 2012
    ..We tested this hypothesis using a new anti-fibrotic drug, FT011 (Fibrotech Therapeutics Pty Ltd), on diabetic Ren-2 rats, a model which replicates many of the structural and functional manifestations of diabetic cardiomyopathy in humans...
  11. pmc Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes
    Luc H Boudreau
    Département de Chimie et Biochimie, Universite de Moncton, Moncton, Canada
    PLoS ONE 7:e31833. 2012
    ..LTs have been directly implicated in inflammatory diseases like asthma, atherosclerosis and rheumatoid arthritis; therefore inhibition of LT biosynthesis is a strategy for the treatment of these chronic diseases...
  12. ncbi Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils
    Takeshi Toyoda
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
    Int J Cancer 125:1786-95. 2009
    ..pylori-induced gastritis in Mongolian gerbils through the suppression of NF-kappaB activation, and may thus have potential for prevention and therapy of H. pylori-associated gastric disorders...
  13. ncbi KS370G, a synthetic caffeamide derivative, improves left ventricular hypertrophy and function in pressure-overload mice heart
    Yi Chun Weng
    Institute of Pharmacology, College of Medicine, National Taiwan University, No 1, Sec 1, Jen Ai Rd, Taipei, Taiwan
    Eur J Pharmacol 684:108-15. 2012
    ..KS370G improved left ventricular function and inhibited cardiac hypertrophy through the decrease of the phosphorylation of ERK, AKT and GSK3β in pressure-overload mice heart...
  14. pmc Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection
    Jennifer Hui Chun Ho
    Graduate Institute of Clinical Medicine, Taipei Medical University, and Department of Ophthalmology, Wang Fang Hospital, Taipei, Taiwan
    J Biomed Sci 18:30. 2011
    ..Besides, the target proteins of salvianolic acids are also described. These results of recent advances have shed new light to the development of novel therapeutic strategies for salvianolic acids to treat cardiovascular diseases...
  15. ncbi Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation
    Z Orban
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Neuroimmunomodulation 7:99-105. 2000
    ..These findings may suggest that novel anti-inflammatory therapies can be based upon activation of NF-kappaB-mediated transcription of genes curbing the inflammatory response and that CAPE or its analogs hold therapeutic promise...
  16. ncbi Antibacterial and free-radical scavenging activities of Sonoran propolis
    C Velazquez
    Department of Chemistry Biology, University of Sonora, Hermosillo, Sonora, Mexico
    J Appl Microbiol 103:1747-56. 2007
    ..To evaluate the antibacterial and free-radical scavenging (FRS) activities of propolis collected from three different areas of Sonoran Desert in northwestern Mexico [Pueblo de Alamos (PAP), Ures (UP) and Caborca (CP)]...
  17. ncbi Antioxidant and prooxidant nature of hydroxycinnamic acid derivatives ferulic and caffeic acids
    Dharmendra Kumar Maurya
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
    Food Chem Toxicol 48:3369-73. 2010
    Dietary polyphenols are beneficial to human health by exerting various biological effects. Ferulic and caffeic acids are hydroxycinnamic acid derivatives widely distributed in plant-derived food products...
  18. pmc Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression
    Nam Joo Kang
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 30:321-30. 2009
    ..These results suggested that this compound could act as a potent chemopreventive agent against skin cancer...
  19. pmc Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis
    Martin Berner
    Pharmazeutische Biologie und Biotechnologie, Institut für Pharmazeutische Wissenschaften, Albert Ludwigs Universität Freiburg im Breisgau, Stefan Meier Strasse 19 VF, 79104 Freiburg, Germany
    J Bacteriol 188:2666-73. 2006
    ..This is not in accordance with the general phenylpropanoid pathway in plants, where trans-p-coumaric acid is first activated before the 3-hydroxylation of its ring takes place...
  20. ncbi Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats
    Ming Kuei Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Toxicol Appl Pharmacol 242:155-64. 2010
    ..Our results showed that Sal A and B attenuated PDGF-induced ROS formation in HSCs, possibly through inhibition of NADPH oxidase. Sal A and B treatments were also effective against hepatic fibrosis in TAA-intoxicated rats...
  21. ncbi Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE)
    John Yang
    Division of Pharmaceutics, College of Pharmacy, The University of Texas, Austin, TX 78712, USA
    Bioorg Med Chem 18:5032-8. 2010
    ..CAPA and three fluorinated analogs were found to be significantly cytoprotective when compared to control, with no significant difference in cytoprotection between caffeic acid phenethyl ester (CAPE) and CAPA...
  22. ncbi Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo
    Hsing Chun Kuo
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, No 110, Section 1, Chien Kuo N Road, Taichung, Taiwan, ROC
    Cancer Lett 234:199-208. 2006
    ..These results suggest that CAPE presents an antitumor potential for glioma by inhibiting the growth of tumor cells...
  23. ncbi Effects of CAPE-like compounds on HIV replication in vitro and modulation of cytokines in vivo
    Chuan Chen Ho
    Department of Dentistry, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan, ROC
    J Antimicrob Chemother 56:372-9. 2005
    ....
  24. ncbi Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells
    Joo Eun Jung
    Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110 799, Korea
    Carcinogenesis 28:1780-7. 2007
    ..Taken together, our results demonstrate that CA and CADPE are potential inhibitors of STAT3 and that they suppress tumor angiogenesis by inhibiting the activity of STAT3, the expression of HIF-1alpha and VEGF...
  25. ncbi Effect of caffeic acid phenethyl ester, an antioxidant from propolis, on inducing apoptosis in human leukemic HL-60 cells
    Y J Chen
    Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan 11221
    J Agric Food Chem 49:5615-9. 2001
    ..These results suggest that CAPE is a potent apoptosis-inducing agent; its action is accompanied by activation of caspase-3, down-regulation of Bcl-2, and up-regulation of Bax in human leukemic HL-60 cells...
  26. pmc Artificial biosynthesis of phenylpropanoic acids in a tyrosine overproducing Escherichia coli strain
    Sun Young Kang
    Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji ro, Ochang eup, Chungbuk 363 883, Republic of Korea
    Microb Cell Fact 11:153. 2012
    ..Recent advances in synthetic biology and metabolic engineering have enabled artificial production of plant secondary metabolites in microorganisms...
  27. pmc A purpose-synthesised anti-fibrotic agent attenuates experimental kidney diseases in the rat
    Richard E Gilbert
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 7:e47160. 2012
    ....
  28. ncbi Anti-human immunodeficiency virus activity of 3,4,5-tricaffeoylquinic acid in cultured cells of lettuce leaves
    Hirotoshi Tamura
    Department of Biochemistry and Food Science, Kagawa University, Miki cho, Japan
    Mol Nutr Food Res 50:396-400. 2006
    ..4 microM. The HIV inhibitory effect of 3,4,5-TCQA was the highest in values among L-CCA, and other dicaffeoylquinic acids. This data will provide a new possibility for creating a new drug design for HIV...
  29. ncbi Chlorogenic acid and caffeic acid are absorbed in humans
    M R Olthof
    Division of Human Nutrition and Epidemiology, Wageningen University, 6700 EV Wageningen, The Netherlands margreet
    J Nutr 131:66-71. 2001
    ..This implies that part of chlorogenic acid from foods will enter into the blood circulation, but most will reach the colon...
  30. ncbi Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells
    Xinyu Wang
    Division of Pharmaceutics, College of Pharmacy, The University of Texas, Austin, TX 78712, USA
    Bioorg Med Chem 14:4879-87. 2006
    ..These results provide some insights into the structural basis of CAPE cytoprotection in this assay, which does not appear to be based solely on direct antioxidant properties...
  31. ncbi Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats
    H Parlakpinar
    Department of Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, Turkey
    Toxicology 207:169-77. 2005
    ..Our results indicated that CAPE acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GEN both at the biochemical and histological level. Thus, CAPE could be effectively combined with GEN treatment...
  32. ncbi Caffeic acid and ferulic acid inhibit UVA-induced matrix metalloproteinase-1 through regulation of antioxidant defense system in keratinocyte HaCaT cells
    Thanyawan Pluemsamran
    Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Photochem Photobiol 88:961-8. 2012
    ..In conclusion, CA and FA provided protective effects on UVA-mediated MMP-1 induction in HaCaT cells possibly through restoration of antioxidant defense system at the cellular and molecular level...
  33. ncbi Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure-activity relationship
    Sopheak Son
    Department of Food Science and Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca, NY 14853, USA
    J Agric Food Chem 50:468-72. 2002
    ..This supports the concept that hydrophobic antioxidants tend to exhibit better antioxidative activity in an emulsion system...
  34. ncbi Stability of caffeic acid phenethyl amide (CAPA) in rat plasma
    John Yang
    Division of Pharmaceutics, College of Pharmacy, The University of Texas, Austin, TX 78712, USA
    Biomed Chromatogr 26:594-8. 2012
    ..95, 0.35 and 0.13 h at 4, 25 and 37 °C, respectively. The energy of activation was found to be 22.1 kcal/mol for CAPA and 14.1 kcal/mol for CAPE. A more stable compound could potentially extend the beneficial effects of CAPE...
  35. ncbi Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers
    G Scapagnini
    Department of Biochemistry, Section of Biochemistry and Molecular Biology, Faculty of Medicine, University of Catania, Italy corrected
    Mol Pharmacol 61:554-61. 2002
    ..This study identifies a novel class of natural substances that could be used for therapeutic purposes as potent inducers of HO-1 in the protection of tissues against inflammatory and neurodegenerative conditions...
  36. ncbi Altitudinal variation of secondary metabolite profiles in flowering heads of Arnica montana cv. ARBO
    Renate Spitaler
    Institut fur Pharmazie, Abteilung Pharmakognosie, Universitat Innsbruck, Innrain 52, A 6020 Innsbruck, Austria
    Phytochemistry 67:409-17. 2006
    ....
  37. ncbi Octylcaffeate induced apoptosis in human leukemia U937 cells
    Mayuko Ujibe
    Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical University, Sendai 981 8558, Japan
    Biol Pharm Bull 28:2338-41. 2005
    ..These findings suggest that the cytotoxicity of octylcaffeate involves the induction of apoptosis...
  38. ncbi Co-production of caffeic acid and p-hydroxybenzoic acid from p-coumaric acid by Streptomyces caeruleus MTCC 6638
    Ashish Sachan
    Natural Product Biotechnology Group, Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur, 721 302, India
    Appl Microbiol Biotechnol 71:720-7. 2006
    ..Under this condition, the addition of 5 mM p-coumaric acid was sufficient for the S. caeruleus culture to produce 150 mg/l caffeic acid, with a molar yield of 16.6% after 96 h of incubation...
  39. ncbi Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates
    Steven C Zammit
    School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Bioorg Med Chem Lett 19:7003-6. 2009
    ..3-Methoxy-4-propargyloxycinnamoyl anthranilate reduces albuminuria in a rat model of progressive diabetes, and thus has potential as an innovative treatment for diabetic nephropathy...
  40. ncbi Evaluation of natural and synthetic compounds from East Asiatic folk medicinal plants on the mediation of cancer
    Tsui Hwa Tseng
    School of Applied Chemistry, Chung Shan Medical University, N0 110, Section 1, Chien Kuo N Road, Taichung 402, Taiwan
    Anticancer Agents Med Chem 6:347-65. 2006
    ..Since phenolic dimmers or trimers are significantly more potent than monomer in vitro and in vivo, a large number of phenolic dimmers or trimers with linker lengths and their pharmacological properties have been investigated...
  41. ncbi Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardiomyocytes after ischemia/reperfusion injury
    Huanjun Pan
    Research Institute of Cardiovascular Disease, Xuzhou Medical College, Xuzhou, Jiangsu, China
    J Cardiovasc Pharmacol 58:535-42. 2011
    ..In summary, our results showed that Sal A prevents I/R-induced myocardial damage by reducing necrosis and apoptosis in isolated rat hearts and cardiomyocytes...
  42. ncbi Inhibition of multiplication of herpes simplex virus by caffeic acid
    Keiko Ikeda
    Division of Virology, Department of Cellular and Molecular Medicine, Graduate School of Medicine, Wakayama Medical University, Wakayama 641 0011, Japan
    Int J Mol Med 28:595-8. 2011
    ....
  43. ncbi Cerebral protection of salvianolic acid A by the inhibition of granulocyte adherence
    Min Jiang
    Nankai University, Tianjin 300071, P R China
    Am J Chin Med 39:111-20. 2011
    ..Meanwhile, Sal A inhibits of granulocyte adherence by decreasing the expression of ICAM-1 in BMEC...
  44. ncbi Inhibitory effect of the alkyl side chain of caffeic acid analogues on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages
    Koji Uwai
    Laboratory of Pharmaceutics, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Bioorg Med Chem 16:7795-803. 2008
    ..Amide and ketone derivatives showed that not only the ester functional group but also the amide and ketone functional groups exhibit an inhibitory effect on NO production...
  45. ncbi Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters
    Jérémie Doiron
    Department of Chemistry and Biochemistry, Universite de Moncton, Moncton, NB, Canada E1A 3E9
    Bioorg Med Chem Lett 19:1118-21. 2009
    ..Caffeoyl cluster showed an improved 5-lipoxygenase inhibitory activity compared to caffeic acid, with caffeoyl trimer 16 and tetramer 19 showing the best 5-lipoxygenase inhibitory activity...
  46. ncbi Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon
    F Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Fitoterapia 73:S38-43. 2002
    ..CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis...
  47. ncbi Caffeic acid phenethyl ester inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using a local delivery system
    H C Ho
    Department of Life Science, Tunghai University, Taichung, Taiwan, ROC
    Cell Mol Biol (Noisy-le-grand) 55:OL1161-7. 2009
    ..Furthermore, CAPE prevents intima thickening in rabbits after balloon angioplasty. These results indicate that CAPE may have therapeutic relevance for the prevention of restenosis during PCI in the treatment of coronary artery diseases...
  48. pmc Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex
    Yuheng Lin
    Biochemical Engineering Program, Faculty of Engineering, The University of Georgia, Athens, GA 30602, USA
    Microb Cell Fact 11:42. 2012
    ..Nowadays, large-scale production of drugs or drug precursors via microbial approaches provides a promising alternative to chemical synthesis and extraction from plant sources...
  49. ncbi Effects of caffeic acid phenethyl ester and alpha-tocopherol on reperfusion injury in rat brain
    M Kemal Irmak
    Department of Histology and Embryology, Gulhane Military Medical Academy, Ankara, Turkey
    Cell Biochem Funct 21:283-9. 2003
    ..Acute administration of both CAPE and alpha-tocopherol suppressed ischaemia-reperfusion-induced cerebral lipid peroxidation and injury, but CAPE seems to offer a better therapeutic advantage over alpha-tocopherol...
  50. ncbi Cardioprotection and matrix metalloproteinase-9 regulation of salvianolic acids on myocardial infarction in rats
    Baohong Jiang
    Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P R China
    Planta Med 75:1286-92. 2009
    ..These findings suggest that early SA treatment is effective to improve LV function; and SA may exert preventative effects against myocardial remodeling after infarction...
  51. ncbi Caffeic acid phenethyl ester induces mitochondria-mediated apoptosis in human myeloid leukemia U937 cells
    Un Ho Jin
    Department of Biological Sciences, Molecular and Cellular Glycobiology Unit, Sungkyunkwan University, 300 Chunchun dong, Jangan gu, Suwon City, Kyunggi Do 440 746, Korea
    Mol Cell Biochem 310:43-8. 2008
    ..From the results, it was concluded that CAPE induces the mitochondria-mediated apoptosis but not death receptors- or ER-mediated apoptosis in U937 cells...
  52. ncbi In vitro and in vivo stability of caffeic acid phenethyl ester, a bioactive compound of propolis
    Nicola Celli
    Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 Santa Maria Imbaro, Chieti, Italy
    J Agric Food Chem 55:3398-407. 2007
    ..Moreover, alcohols should be carefully used in vivo as solvents for caffeic acid phenethyl ester, since they can give rise to new bioactive caffeic acid esters...
  53. ncbi CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells
    Eun Soo Lee
    Department of Anatomy, Korea University College of Medicine, 126 1 Anam dong 5 ga, Seongbuk gu, Seoul 136 705, South Korea
    Biochem Biophys Res Commun 361:854-8. 2007
    ..Furthermore, CAPE enhanced both insulin-mediated Akt activation and glucose uptake. In summary, our results suggest that CAPE may have beneficial roles in glucose metabolism via stimulation of the AMPK pathway...
  54. pmc Caffeic acid phenethyl ester inhibits nuclear factor-kappaB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells
    L C Wang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Clin Exp Immunol 160:223-32. 2010
    ..This study provides a new insight into the mechanisms of CAPE for immune regulation and a rationale for the use of propolis for the treatment of allergic disorders...
  55. ncbi In vivo effects of caffeic acid phenethyl ester on myocardial ischemia-reperfusion injury and apoptotic changes in rats
    Kerim Cagli
    Division of Cardiovascular Surgery, Yuksek Ihtisas Hospital, Ankara, Turkey
    Ann Clin Lab Sci 35:440-8. 2005
    ..The I/R+CAPE group showed reduced apoptosis, attenuated NO production, elevated myocardial superoxide dismutase (SOD) activity, and diminished serum CK and AST activities, compared to the I/R group...
  56. ncbi Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats
    U Koltuksuz
    Departments of Pediatric Surgery, Radiology, Biochemistry, and Pathology, , School of Medicine, Malatya, Turkey
    J Pediatr Surg 36:1504-9. 2001
    ..Those effects of CAPE may occur through its antiinflammatory, immunomodulatory, and antioxidant properties, and EGF may occur through its induced proliferative properties on the esophagus...
  57. ncbi Plasma levels of caffeic acid and antioxidant status after red wine intake
    P Simonetti
    Department of Food Science and Microbiology, Division of Human Nutrition, University of Milan, Via Celoria 2, 20133 Milan, Italy
    J Agric Food Chem 49:5964-8. 2001
    ..The results indicate that caffeic acid is bioavailable and it may be correlated with the antioxidant potential of plasma...
  58. ncbi The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells
    Y J Chen
    Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan, ROC
    Anticancer Drugs 12:143-9. 2001
    ..These results suggest that apoptosis induced by CAPE is associated with mitochondrial dysfunction, GSH depletion and selective scavenging of H2O2 in human leukemic HL-60 cells...
  59. pmc Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis
    Paolo Onori
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    Int J Cancer 125:565-76. 2009
    ..CAPE both in vivo and in vitro decreases the growth of CCH cells by increasing apoptosis. These results demonstrate that CAPE might be an important therapeutic tool in the treatment of CCH...
  60. ncbi The effects of the caffeic acid phenethyl ester (CAPE) on erythrocyte membrane damage after hind limb ischaemia-reperfusion
    Lulufer Tamer
    Department of Biochemistry, Medical Faculty, Mersin University, 33079 Mersin, Turkey
    Cell Biochem Funct 22:287-90. 2004
    ..Therefore, we suggest that in order to decrease I/R injury, pre-administration of CAPE may be a promising agent for a variety of conditions associated with I/R...
  61. ncbi Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart
    Huseyin Okutan
    Department of Cardiovascular Surgery, Suleyman Demirel University Medical School, 6 Mart Ataturk C Istiklal M Oztunc A, No 1 D 4 32050 Isparta, Turkey
    Clin Biochem 38:191-6. 2005
    ..In light of the antioxidant ability of CAPE, the effects of CAPE on the antioxidative status of cardiac tissue were investigated in streptozotocin (STZ)-induced diabetic rats...
  62. pmc Inhibitory effect of caffeic acid phenethyl ester on the growth of SW480 colorectal tumor cells involves beta-catenin associated signaling pathway down-regulation
    Yu Jun He
    Department of General Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China
    World J Gastroenterol 12:4981-5. 2006
    ..To study the anti-tumor effect of caffeic acid phenethyl ester (CAPE) and the influence of CAPE on beta-catenin associated signaling pathway in SW480 colorectal cancer (CRC) cells...
  63. ncbi Antihyperglycemic effect of a caffeamide derivative, KS370G, in normal and diabetic mice
    Yi Chun Weng
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    J Agric Food Chem 58:10033-8. 2010
    ..Hence, the hypoglycemic effect of KS370G in normal and diabetic mice could be attributed to the stimulation of insulin release and the increase of glucose utilization...
  64. ncbi Oral flavonoid supplementation attenuates atherosclerosis development in apolipoprotein E-deficient mice
    Keiichi Hishikawa
    Department of Clinical Renal Regeneration, University of Tokyo, Japan
    Arterioscler Thromb Vasc Biol 25:442-6. 2005
    ..We examined the effects of oral CAPE supplementation on atherogenesis in apolipoprotein E-deficient (apoE-/-) mice...
  65. ncbi Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats
    Shou bao Wang
    National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No 1 Xian Nong Tan Street, Beijing 100050, PR China
    Eur J Pharmacol 615:125-32. 2009
    ..The results of our study suggest that salvianolic acid A possessing antioxidant activity has a significant protective effect against isoproterenol-induced myocardial infarction...
  66. ncbi The ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged rats
    Mukaddes Esrefoglu
    Department of Histology and Embryology, Faculty of Medicine, 44280 Malatya, Turkey
    Fundam Clin Pharmacol 24:305-15. 2010
    ..Taking the results together, we suggest that supplemental administration of caffeic acid phenethyl ester and melatonin is beneficial in delaying age-related cellular damage in nervous system...
  67. ncbi Structure-activity relationships in the cytoprotective effect of caffeic acid phenethyl ester (CAPE) and fluorinated derivatives: effects on heme oxygenase-1 induction and antioxidant activities
    Xinyu Wang
    Pharmaceutics Division, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
    Eur J Pharmacol 635:16-22. 2010
    ..These results indicate that the induction of HO-1 plays a more important role in the cytoprotective activity of CAPE derivatives than their direct antioxidant activity...
  68. ncbi Caffeic acid phenethyl ester induces apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction
    Ming Jen Chen
    Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medicine, Nursing and Management College, Taipei, Taiwan, ROC
    Pancreatology 8:566-76. 2008
    ..This study aimed to investigate the effect of caffeic acid phenethyl ester (CAPE), an active component isolated from honeybee propolis, in inducing apoptosis in human pancreatic cancer cells...
  69. ncbi Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury
    Jiangning Tan
    Department of Pediatric Cardiology, Anzhen Hospital, Capital Medical University, Beijing, China
    Am J Physiol Heart Circ Physiol 289:H2265-71. 2005
    ..Importantly, protection is conferred when CAPE is systemically administered after the onset of ischemia, thus demonstrating potential efficacy in the clinical scenario...
  70. ncbi Caffeic acid phenethyl ester (CAPE) may be a promising adjuvant treatment in gastric cancer
    Ulysses Ribeiro
    J Clin Gastroenterol 41:871-3. 2007
  71. ncbi Sulindac sulfide and caffeic acid phenethyl ester suppress the motility of lung adenocarcinoma cells promoted by transforming growth factor-beta through Akt inhibition
    Yasushi Shigeoka
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, 86 Nishimachi, 683 8503 Yonago, Japan
    J Cancer Res Clin Oncol 130:146-52. 2004
    ..Our observations raise the possibility that these agents, except for (+)-catechin, can be applied not only as chemopreventive agents but also as anti-metastatic therapy...
  72. ncbi Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways
    Haifang Xiao
    College of Food Science and Engineering, Northwest A and F University, Yangling, Shaanxi, PR China
    J Agric Food Chem 61:1509-20. 2013
    ..Pretreatment with the antioxidant N-acetylcysteine (NAC) significantly blocked cell death and changes of Akt and MAPK signalings induced by chicoric acid. In addition, chicoric acid down regulated HO-1 and COX-2 via the PI3K/Akt pathway...
  73. ncbi Caffeic acid phenethyl ester protects against oxidative stress-related renal dysfunction in rats treated with cyclosporin A
    Orawan Wongmekiat
    Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Fundam Clin Pharmacol 25:619-26. 2011
    ..The protection afforded by CAPE is mediated, at least in part, through inhibiting renal lipid peroxidation and enhancing or maintaining the antioxidant glutathione content...
  74. pmc A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model
    Claudia Esther Carrasco-Legleu
    Departamento de Biologia Celular, Laboratorio 50, Centro de Investigación y de Estudios Avanzados del IPN Cinvestav Ave IPN 2508 Col San Pedro Zacatenco, C P 07360, Mexico, D F, Mexico
    World J Gastroenterol 12:6779-85. 2006
    ..To study of the effect of caffeic acid phenethyl ester (CAPE) on the initiation period in a medium-term assay of hepatocarcinogenesis...
  75. ncbi Antioxidant activity of phenolic acids and their metabolites: synthesis and antioxidant properties of the sulfate derivatives of ferulic and caffeic acids and of the acyl glucuronide of ferulic acid
    A Piazzon
    Agricultural Research Council, Rome, Italy
    J Agric Food Chem 60:12312-23. 2012
    ..Moreover, we first demonstrate the ex vivo synthesis of the acyl glucuronide of ferulic acid by mouse liver microsomes, in addition to the phenyl glucuronide...
  76. ncbi The flavanoide caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity
    Carmen Noelker
    Department of Neurology, Friedrich Wilhelms University, Bonn, Germany
    Neurosci Lett 383:39-43. 2005
    ....
  77. ncbi Engineering E. coli for caffeic acid biosynthesis from renewable sugars
    Haoran Zhang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Room 56 469, Cambridge, MA 02139, USA
    Appl Microbiol Biotechnol 97:3333-41. 2013
    ..The highest specific caffeic acid production achieved was 38 mg/L/OD. Lastly, cultivation of engineered E. coli in a bioreactor resulted in a production of 106 mg/L caffeic acid after 4 days...
  78. ncbi Protective effects of caffeic acid phenethyl ester (CAPE) on amikacin-induced nephrotoxicity in rats
    Hakan Parlakpinar
    Department of Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey
    Cell Biochem Funct 24:363-7. 2006
    ..Morphological tubule damage in rats given AK was severe in the renal cortex, whereas in rats given AK plus CAPE, no histological changes occurred. It is concluded that CAPE could be useful for reducing the nephrotoxic effects of AK...
  79. ncbi Synthesis, biological evaluation, and structure-activity relationship study of novel cytotoxic aza-caffeic acid derivatives
    Hongbin Zou
    Institute of Material Medica, College of Pharmaceutical Sciences, Zhejiang University, 383 Yu Hang Tang Road, Hangzhou 310058, China
    Bioorg Med Chem 18:6351-9. 2010
    ..Flow cytometric and western blot analysis indicate that compound 80 plays a role in mitochondria-dependent apoptosis activity by suppressing K562 cell proliferation in a concentration- and time-dependent manner...
  80. ncbi Salvianolic acid A suppress lipopolysaccharide-induced NF-κB signaling pathway by targeting IKKβ
    Kwang Seok Oh
    Bio organic Science Division, Korea Research Institute of Chemical Technology, 141 Gajeong ro, Yuseong, Daejeon 305 343, Republic of Korea
    Int Immunopharmacol 11:1901-6. 2011
    ....
  81. ncbi Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration
    C V Fontanilla
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroscience 188:135-41. 2011
    ..Thus, CAPE may have beneficial effects in slowing or preventing the progression of Parkinson's disease and other neurodegenerative disorders...
  82. ncbi Protective effects of caffeic acid phenethyl ester (CAPE) on intestinal damage in necrotizing enterocolitis
    Cuneyt Tayman
    Department of Neonatology, Fatih University Faculty of Medicine, Ankara, Turkey
    Pediatr Surg Int 27:1179-89. 2011
    ..To determine the preventative effect of caffeic acid phenethyl ester (CAPE) in necrotizing enterocolitis (NEC) in an experimental rat model of NEC...
  83. ncbi FT23, an orally active antifibrotic compound, attenuates structural and functional abnormalities in an experimental model of diabetic cardiomyopathy
    Sih Min Tan
    The University of Melbourne, Department of Medicine, St Vincent s Hospital, Fitzory, Australia
    Clin Exp Pharmacol Physiol 39:650-6. 2012
    ..The results of the present study suggest that FT23 inhibits the activity of TGF-β and attenuates structural and functional manifestations of diastolic dysfunction observed in a model of diabetic cardiomyopathy...
  84. ncbi Protective role of caffeic acid phenethyl ester and erdosteine on activities of purine-catabolizing enzymes and level of nitric oxide in red blood cells of isoniazid-administered rats
    H R Yilmaz
    Department of Medical Biology, School of Medicine, Suleyman Demirel University, Isparta, Turkey
    Toxicol Ind Health 24:519-24. 2008
    ..CAPE and erdosteine may have protective potential in this process and they may become a promising drug in the prevention of this undesired side effect of INH...
  85. ncbi Salvianolic acid A displays cardioprotective effects in in vitro models of heart hypoxia/reoxygenation injury
    Yu Qin Zhang
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    J Asian Nat Prod Res 12:899-915. 2010
    ..These results suggested that 1 had significant protective effects against H/R-induced myocardial injury through its antioxidant activity...
  86. ncbi Caffeic acid phenethyl ester (CAPE) supplemented St. Thomas' hospital cardioplegic solution improves the antioxidant defense system of rat myocardium during ischemia-reperfusion injury
    Murat Ozeren
    Mersin University School of Medicine, Department of Cardiovascular Surgery, Kalp Damar Cerrahisi A D, Zeytinlibahce Caddesi, 33079 Mersin, Turkey
    Pharmacol Res 52:258-63. 2005
    ..We investigated the advantages of CAPE supplemented cardioplegic solution (St. Thomas' Hospital cardioplegic solution No.: 2) on the antioxidant defense system of myocardium against ischemia-reperfusion injury...
  87. ncbi Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: the role of heme oxygenase-1
    Xinyu Wang
    College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, USA
    Eur J Pharmacol 591:28-35. 2008
    ....
  88. ncbi Effects of caffeic acid phenethyl ester (CAPE) on sepsis in rats
    Ahmet Tekin
    Meram Medical Faculty, Department of General Surgery, Selcuk University, Konya, Turkey
    Inflammation 31:273-80. 2008
    ..These results support that CAPE may be used for the treatment of organ failure during sepsis...
  89. ncbi Establishment of adventitious root cultures of Echinacea purpurea for the production of caffeic acid derivatives
    Kee Yoeup Paek
    Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju, South Korea
    Methods Mol Biol 547:3-16. 2009
    ..The detailed methodology for high-performance liquid chromatographic analysis of caffeic acid derivatives present in the adventitious roots is also discussed...
  90. ncbi Inhibitory effect of caffeic acid on cancer cell proliferation by oxidative mechanism in human HT-1080 fibrosarcoma cell line
    N Rajendra Prasad
    Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Chidambaram, Tamilnadu, India
    Mol Cell Biochem 349:11-9. 2011
    ..These data suggest that caffeic acid exhibits potent anticancer effect in HT-1080 cell line, and that it may be used as an anticancer agent...
  91. ncbi Protective effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia-reperfusion-induced apoptotic cell death
    H Parlakpinar
    Department of Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, Turkey
    Toxicology 209:1-14. 2005
    ..We propose that CAPE acts in the heart as a potent scavenger of free radicals to prevent the apoptotic effect of I/R. Further studies are needed to elucidate the mechanisms of apoptotic death machinery...
  92. ncbi Salvianolic acid A protects against vascular endothelial dysfunction in high-fat diet fed and streptozotocin-induced diabetic rats
    Xiu Ying Yang
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    J Asian Nat Prod Res 13:884-94. 2011
    ..Our data suggested that SalA could protect against vascular VED in diabetes, which might attribute to its suppressive effect on oxidative stress and AGEs-induced endothelial dysfunction...
  93. ncbi Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity
    X Wei
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroscience 155:1098-105. 2008
    ..This finding may further help understanding of the mechanism of glutamate-induced neuronal death and CAPE-induced neuroprotection against excitotoxicity...
  94. ncbi Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains
    Bianca Sperl
    Department of Molecular Biology, Max Planck Institute of Biochemistry, and Center for Integrated Protein Science Munich, Am Klopferspitz 18, 82152 Martinsried, Germany
    Bioorg Med Chem Lett 19:3305-9. 2009
    ..Moreover, we propose a binding mode for the inhibitors based on molecular modeling, which will facilitate chemical optimization efforts of these important lead structures for drug discovery...
  95. ncbi A sensitive method for determination of salvianolic acid A in rat plasma using liquid chromatography/tandem mass spectrometry
    Lixia Pei
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    Biomed Chromatogr 22:786-94. 2008
    ..5 h, the area under the plasma concentration-time curve (AUC0-12 h) was 698 +/- 129 ng.h/mL, and the elimination half-life (T1/2) was 3.29 h...
  96. ncbi Synthesis of a benzyl-protected analog of arenarioside, a trisaccharide phenylpropanoid glycoside
    Feng Yan Zhou
    Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China
    Carbohydr Res 341:2469-77. 2006
    ..This is the first approach on the synthesis of a trisaccharide phenylpropanoid glycoside, although the benzyl-protecting group in the backbone of the arenarioside analog could not be removed by conventional debenzylation procedures...
  97. ncbi Chromatographic fingerprinting analysis of Danshen root (Salvia miltiorrhiza Radix et Rhizoma) and its preparations using high performance liquid chromatography with diode array detection and electrospray mass spectrometry (HPLC-DAD-ESI/MS)
    Mei Liu
    Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    J Sep Sci 30:2256-67. 2007
    ..The established CFPs demonstrate the representative chemical profiling of the existing components and can be applied to the authentication and quality assessment of Danshen roots and other Danshen containing formulated preparations...
  98. ncbi Enzymatic synthesis of cinnamic acid derivatives
    Gia Sheu Lee
    Department of Chemical Engineering, National Taiwan University of Science and Technology, 43 Keelung Road, Section 4, Taipei 106 07, Taiwan
    Biotechnol Lett 28:581-5. 2006
    ..The enzyme can be reused several times before significant activity loss was observed...
  99. ncbi Isolation and purification of salvianolic acid A and salvianolic acid B from Salvia miltiorrhiza by high-speed counter-current chromatography and comparison of their antioxidant activity
    Yinshi Sun
    College of Agronomy, Shandong Agricultural University, Taian 271018, China
    J Chromatogr B Analyt Technol Biomed Life Sci 877:733-7. 2009
    ..43+/-0.09 and 1.81+/-0.01 microg/ml in DPPH radical method. The ABTS results showed that Sal A and Sal B exhibited high total antioxidant activities, their EC(50) values were 1.35+/-0.00 and 1.43+/-0.01 microg/ml, respectively...
  100. ncbi Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress
    Baohong Jiang
    Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    Food Chem Toxicol 46:1510-5. 2008
    ....
  101. ncbi Total synthesis of syringalide B, a phenylpropanoid glycoside
    Qing Li
    Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Health Sciences Center, Beijing 100083, PR China
    Carbohydr Res 340:1601-4. 2005
    ..The hydroxyl groups were protected with allyloxycarbonyl (Aoc) and allyl groups, which successfully prevent the migration of the feruloyl group during the deblocking procedure...

Research Grants11

  1. MACROPHAGE ACTIVATION AND LIPOPROTEIN METABOLISM
    Maria Lopes Virella; Fiscal Year: 2001
    ..Our overall objective is to provide insight into the mechanisms by which anti-LDL antibodies and macrophage activation may contribute to the development(acceleration of the arteriosclerotic process. ..
  2. Phenotypes of HIV-1 Integrases
    William Robinson; Fiscal Year: 2009
    ..Inhibitors of integrase are in clinical testing. Understanding how HIV becomes resistant to these compounds and how such compounds interact with integrase are fundamental to the synthesis of better anti-HIV drugs. ..
  3. AMYGDALA PLASTICITY IN PAIN
    ROBERT GEREAU; Fiscal Year: 2008
    ..These studies will lay important groundwork for future investigations of the[unreadable] importance of amygdala ERK signaling in pain sensitization. ..
  4. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2008
    ..abstract_text> ..
  5. Midwest Regional Pain Interest Group Meeting
    ROBERT GEREAU; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. 2-METHOXYESTRADIOL & HORMONAL CANCER
    Bao Ting Zhu; Fiscal Year: 2006
    ..The results will also provide novel mechanistic understanding for the biological actions of 2-MeO-E2. ..
  7. Selective Induction of Estrogen Conjugative Metabolism
    Bao Ting Zhu; Fiscal Year: 2006
    ..These studies will also provide examinations of the important roles of bioactive estrogen metabolites (e.g., 4-OH-E2 and 16alpha-OH-E2) in estrogen-induced cancers. ..
  8. FUNCTION AND MODULATION OF METABOTROPIC GLU RECEPTOR 5
    ROBERT GEREAU; Fiscal Year: 2003
    ..These studies will help identify the specific functions and mechanism of modulation of mGlu5 in hippocampus. ..
  9. Defining an HIV Integrase Inhibitor Binding Pocket
    William Robinson; Fiscal Year: 2004
    ..Moreover, by understanding the nature of inhibitor resistance, new molecules with activity against inhibitor-resistant HIV can be designed and synthesized. ..
  10. Dietary Polyphenols Are Consequential Epigenetic Modulators of Gene Expression
    BAOTING ZHU; Fiscal Year: 2009
    ..It is expected that the outcomes of the proposed studies will have direct clinical utility in the near future and far-reaching human health implications. ..
  11. REACTIVE NITROGEN & CEREBRAL ISCHEMIC INJURY
    MUSH KHAN; Fiscal Year: 2003
    ....