cinnamates

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Top Publications

  1. ncbi A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
    Michael Boyce
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 307:935-9. 2005
  2. ncbi Exogenous caffeic acid inhibits the growth and enhances the lignification of the roots of soybean (Glycine max)
    Gisele Adriana Bubna
    Laboratory of Plant Biochemistry, Department of Biochemistry, University of Maringa, Av Colombo, 5790, 87020 900 Maringa, PR, Brazil
    J Plant Physiol 168:1627-33. 2011
  3. ncbi Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages
    Shanlou Qiao
    Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    Free Radic Res 39:995-1003. 2005
  4. ncbi Molecular characterization of a stable antisense chalcone synthase phenotype in strawberry (Fragaria x ananassa)
    Stefan Lunkenbein
    Biomolecular Food Technology, Technical University Munchen, Lise Meitner Strasse 34, 85354 Freising, Germany
    J Agric Food Chem 54:2145-53. 2006
  5. ncbi Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning
    Rui Sheng
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 8:310-25. 2012
  6. ncbi Endoplasmic reticulum stress-mediated apoptosis of EBV-transformed B cells by cross-linking of CD70 is dependent upon generation of reactive oxygen species and activation of p38 MAPK and JNK pathway
    Ga Bin Park
    Department of Anatomy and Research Center for Tumor Immunology, Inje University College of Medicine, Busan, Korea
    J Immunol 185:7274-84. 2010
  7. ncbi Sunscreens in human plasma and urine after repeated whole-body topical application
    N R Janjua
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
    J Eur Acad Dermatol Venereol 22:456-61. 2008
  8. ncbi Rosmarinic acid
    Maike Petersen
    Institut fur Pharmazeutische Biologie, Philipps Universitat Marburg, Deutschhausstr 17A, D 35037 Marburg, Germany
    Phytochemistry 62:121-5. 2003
  9. pmc Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor
    Lulu Farhana
    John D Dingell Veterans Affairs Medical Center, 4646 John R Street, Detroit, MI 48201, USA
    Cancer Res 67:318-25. 2007
  10. ncbi Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice
    C Girish
    Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research JIPMER, Pondicherry, India
    Fundam Clin Pharmacol 23:735-45. 2009

Detail Information

Publications253 found, 100 shown here

  1. ncbi A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
    Michael Boyce
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 307:935-9. 2005
    ..More broadly, salubrinal demonstrates the feasibility of selective pharmacological targeting of cellular dephosphorylation events...
  2. ncbi Exogenous caffeic acid inhibits the growth and enhances the lignification of the roots of soybean (Glycine max)
    Gisele Adriana Bubna
    Laboratory of Plant Biochemistry, Department of Biochemistry, University of Maringa, Av Colombo, 5790, 87020 900 Maringa, PR, Brazil
    J Plant Physiol 168:1627-33. 2011
    ..These results indicate that exogenously applied caffeic acid can be channeled into the phenylpropanoid pathway via the 4CL reaction, resulting in an increase of lignin monomers that solidify the cell wall and inhibit root growth...
  3. ncbi Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages
    Shanlou Qiao
    Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    Free Radic Res 39:995-1003. 2005
    ....
  4. ncbi Molecular characterization of a stable antisense chalcone synthase phenotype in strawberry (Fragaria x ananassa)
    Stefan Lunkenbein
    Biomolecular Food Technology, Technical University Munchen, Lise Meitner Strasse 34, 85354 Freising, Germany
    J Agric Food Chem 54:2145-53. 2006
    ....
  5. ncbi Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning
    Rui Sheng
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 8:310-25. 2012
    ..These results demonstrated that pre-activation of autophagy by ischemic preconditioning can boost endogenous defense mechanisms to upregulate molecular chaperones, and hence reduce excessive ER stress during fatal ischemia...
  6. ncbi Endoplasmic reticulum stress-mediated apoptosis of EBV-transformed B cells by cross-linking of CD70 is dependent upon generation of reactive oxygen species and activation of p38 MAPK and JNK pathway
    Ga Bin Park
    Department of Anatomy and Research Center for Tumor Immunology, Inje University College of Medicine, Busan, Korea
    J Immunol 185:7274-84. 2010
    ..Our report reveals alternate mechanisms of direct apoptosis through CD70 signaling and provides data supporting CD70 as a viable target for an Ab-based therapy against EBV-related tumors...
  7. ncbi Sunscreens in human plasma and urine after repeated whole-body topical application
    N R Janjua
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
    J Eur Acad Dermatol Venereol 22:456-61. 2008
    ..For all three compounds, only sporadic measurements of percutaneous absorption and excretion after topical application in humans have been described...
  8. ncbi Rosmarinic acid
    Maike Petersen
    Institut fur Pharmazeutische Biologie, Philipps Universitat Marburg, Deutschhausstr 17A, D 35037 Marburg, Germany
    Phytochemistry 62:121-5. 2003
    ..For this reason a biotechnological production of rosmarinic acid with plant cell cultures has been proposed...
  9. pmc Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor
    Lulu Farhana
    John D Dingell Veterans Affairs Medical Center, 4646 John R Street, Detroit, MI 48201, USA
    Cancer Res 67:318-25. 2007
    ..These results suggest that AHPN/3-Cl-AHPC and their analogues are SHP ligands and their induction of apoptosis is mediated by their binding to the SHP receptor...
  10. ncbi Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice
    C Girish
    Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research JIPMER, Pondicherry, India
    Fundam Clin Pharmacol 23:735-45. 2009
    ..These active phytochemicals may be developed as drugs for the treatment of liver diseases...
  11. ncbi Rosmarinic acid protects against experimental sepsis by inhibiting proinflammatory factor release and ameliorating hemodynamics
    Wang Lin Jiang
    College of Marine Life Science, Ocean University of China, Qingdao, People s Republic of China
    Shock 32:608-13. 2009
    ..The anti-inflammatory mechanism of RA may inhibit activation of the nuclear factor- kappaB pathway by inhibiting IkappaB kinase activity...
  12. pmc Chemical inactivation of the cinnamate 4-hydroxylase allows for the accumulation of salicylic acid in elicited cells
    Guillaume A Schoch
    Department of Plant Stress Response, Institute of Plant Molecular Biology, Centre National de la Recherche Scientifique Unité Propre de Recherche 2357, Universite Louis Pasteur, 28 rue Goethe, F 67000 Strasbourg, France
    Plant Physiol 130:1022-31. 2002
    ..Mechanism-based C4H inactivators, thus, are promising tools for the elucidation of the CA-derived SA biosynthetic pathway and for the potentiation of plant defense...
  13. ncbi Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis
    Miriam Cnop
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Biol Chem 282:3989-97. 2007
    ..This modifies the present paradigm regarding the beneficial role of eIF2alpha phosphorylation in beta-cells and must be taken into consideration when designing therapies to protect beta-cells in type 2 diabetes...
  14. ncbi A chlorophyll fluorescence analysis of photosynthetic efficiency, quantum yield and photon energy dissipation in PSII antennae of Lactuca sativa L. leaves exposed to cinnamic acid
    M Iftikhar Hussain
    Department of Plant Biology and Soil Science, University of Vigo, Campus Lagoas Marcosende, 36310 Vigo, Spain
    Plant Physiol Biochem 49:1290-8. 2011
    ..CA (1.5 mM) also decreased the leaf protein contents of L. sativa as compared to control...
  15. ncbi Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism
    Naomi Osakabe
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan co jp
    Biofactors 21:127-31. 2004
    ..In addition, the anti-inflammatory mechanism of RA also estimated in the ear edema models...
  16. ncbi Synthesis and antiviral activities of amide derivatives containing the alpha-aminophosphonate moiety
    De Yu Hu
    Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China
    J Agric Food Chem 56:998-1001. 2008
    ..6 microg/mL). To the best of our knowledge, this is the first report on the synthesis and antiviral activity of amide derivatives containing an alpha-aminophosphonate moiety...
  17. ncbi The combination of 4-anilinoquinazoline and cinnamic acid: a novel mode of binding to the epidermal growth factor receptor tyrosine kinase
    Dong Dong Li
    State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People s Republic of China
    Bioorg Med Chem 19:5012-22. 2011
    ..Compound 43 has demonstrated significant EGFR (IC(50)=0.12 μM) and tumor growth inhibitory activity as a potential anticancer agent...
  18. ncbi Long term effect of aflatoxin B(1) on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin
    R Rastogi
    Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India
    Phytother Res 15:307-10. 2001
    ..p) -toxicated rats, while drug (picroliv and silymarin both) treatment reversed the condition to near normal levels. The effects of picroliv and silymarin were comparable...
  19. pmc Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction
    Guorui Dou
    Arnold and Beckman Macular Research Center, Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA
    Free Radic Biol Med 53:1111-22. 2012
    ..Thus, these data collectively demonstrate that αB crystallin provides critical protection of mitochondrial function during ER stress-induced RPE apoptosis...
  20. ncbi Cinnamic acid inhibits proliferation and modulates brush border membrane enzyme activities in Caco-2 cells
    C Ekmekcioglu
    Department of Medical Physiology, University of Vienna Medical School, Austria
    Cancer Lett 128:137-44. 1998
    ..Intracellular cAMP levels were decreased significantly after 1 h of treatment with 8.0 mM cinnamic acid, suggesting that cinnamic acid induces its effects on enzyme activities partly by modulating the cAMP signaling pathway...
  21. ncbi A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death
    M Boyce
    Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    Cell Death Differ 15:589-99. 2008
    ..Our work identifies eEF-2K as a new component of the ER stress response and underlines the utility of novel small molecules in discovering new cell biology...
  22. pmc Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors
    Hannes C A Drexler
    Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Muenster, Germany
    PLoS ONE 4:e4161. 2009
    ....
  23. ncbi Isolation and characterization of novel benzoates, cinnamates, flavonoids, and lignans from Riesling wine and screening for antioxidant activity
    B Baderschneider
    , Schleinitzstrasse 20, DE-38106 Braunschweig, Germany
    J Agric Food Chem 49:2788-98. 2001
    ..Structural elucidation of the newly isolated wine constituents is reported together with the determination of their antioxidant activity...
  24. ncbi Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts
    A Zdarilova
    Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Hnevotinska 3, Palacky University, 775 15 Olomouc, Czech Republic
    Toxicol In Vitro 23:386-92. 2009
    ..The effects of PVE and RA are presumably linked to their anti-inflammatory activities and thus use of PVE and RA may be relevant in modulating the inflammation process, including periodontal disease...
  25. ncbi Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene
    Longkuan Xiang
    College of Pharmacy and the Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Biol Chem 277:32505-9. 2002
    ....
  26. ncbi RNAi-mediated suppression of the phenylalanine ammonia-lyase gene in Salvia miltiorrhiza causes abnormal phenotypes and a reduction in rosmarinic acid biosynthesis
    Jie Song
    Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Shaanxi Normal University, Xi an 710062, People s Republic of China
    J Plant Res 124:183-92. 2011
    ..Our results indicate that PAL is very important for the synthesis of major water-soluble pharmaceutical ingredients within S. miltiorrhiza...
  27. ncbi Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition
    Silvia Moreno
    Instituto de Investigaciones Bioquimicas, Buenos Aires I I B B A CONICET, Universidad de Buenos Aires, Fundacion Instituto Leloir, Facultad de Ciencias Exactas y Naturales, Patricias Argentinas 435, Buenos Aires, 1405, Argentina
    Free Radic Res 40:223-31. 2006
    ..From a practical point of view, rosemary extract may be a good candidate for functional foods as well as for pharmaceutical plant-based products...
  28. ncbi Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of Jurkat cells which was suppressed by Bcl-2
    Evangelos Kolettas
    Cell and Molecular Physiology Unit, Laboratory of Physiology, School of Medicine, University of Ioannina, 45110, Ioannina, Greece
    Mol Cell Biochem 285:111-20. 2006
    ....
  29. ncbi Light and temperature regulated terpene biosynthesis: hepatoprotective monoterpene picroside accumulation in Picrorhiza kurrooa
    Tabasum Kawoosa
    Biotechnology Division, Institute of Himalayan Bioresource Technology CSIR, P O Box No 6, Palampur, 176061, Himachal Pradesh, India
    Funct Integr Genomics 10:393-404. 2010
    ..Data suggested the important roles played by light and temperature in regulating pkhmgr and pkdxs, and the picrosides level in picrorhiza...
  30. ncbi Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats
    Majid Tavafi
    Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
    Tissue Cell 43:392-7. 2011
    ..05). In conclusion, RA alleviates GS nephrotoxicity via antioxidant activity, increase of renal GSH content and increase of renal antioxidant enzymes activity...
  31. ncbi Evolution of rosmarinic acid biosynthesis
    Maike Petersen
    Institut fur Pharmazeutische Biologie, Philipps Universitat Marburg, Marburg, Germany
    Phytochemistry 70:1663-79. 2009
    ....
  32. ncbi Lipophilic caffeic acid derivatives protect cells against H2O2-Induced DNA damage by chelating intracellular labile iron
    Natalia Kitsati
    Laboratory of Biological Chemistry, School of Medicine, University of Ioannina, Ioannina, Greece
    J Agric Food Chem 60:7873-9. 2012
    ....
  33. pmc Evaluation of octyl p-methoxycinnamate included in liposomes and cyclodextrins in anti-solar preparations: preparations, characterizations and in vitro penetration studies
    Mariana Sato de Souza de Bustamante Monteiro
    Medicines Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Int J Nanomedicine 7:3045-58. 2012
    ..The inclusion of sunscreen molecules in different release systems, like liposomes (lipo) and cyclodextrins (CD) is therefore required...
  34. ncbi Changes in bioactive components related to the harvest time from the spicas of Prunella vulgaris
    Yuhang Chen
    Institute of Chinese Medicinal Materials, Nanjing Agricultural University, Nanjing, China
    Pharm Biol 50:1118-22. 2012
    ..vulgaris has been used as traditional medicine in China for over a hundred years. To our best knowledge, no study has been conducted to determine the influence of harvesting time on concentrations of bioactive compounds of P. vulgaris...
  35. ncbi A new sunscreen of the cinnamate class: synthesis and enzymatic hydrolysis evaluation of glyceryl esters of p-methoxycinnamic acid
    Zaida Maria Faria de Freitas
    Departamento de Medicamentos, Universidade Federal do Rio de Janeiro, CCS bloco K, 2 andar, Sala 50, Ilha do Fundao, CEP 21941 590, Rio de Janeiro, Brazil
    Eur J Pharm Sci 25:67-72. 2005
    ..This finding suggests that this triacylglycerol can possibly have a longer retention time in the skin and consequently promote a more intense and effective antisolar action than the commercial sunscreen...
  36. pmc Endoplasmic reticulum stress causes EBV lytic replication
    Gwen Marie Taylor
    Department of Pathology, University of Pittsburgh and Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Blood 118:5528-39. 2011
    ..Microarray analysis identified candidate genes governing lytic replication in LCLs undergoing ER stress...
  37. ncbi Selective trans-cinnamic acid uptake impairs [Ca2+]cyt homeostasis and growth in Cucumis sativus L
    Jingquan Yu
    Department of Horticulture, Huajiachi Campus, Zhejiang University, Hangzhou, People s Republic of China
    J Chem Ecol 35:1471-7. 2009
    ..Taken together, these results suggest that [Ca(2+)](cyt) homeostatic disturbance is one of the primary triggers for trans-CA phytotoxicity in cucumber...
  38. pmc Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. II. Effect on chorda tympani salt responses
    Vijay Lyall
    Department of Physiology, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 125:587-600. 2005
    ..VR-1 KO mice demonstrated no Bz-insensitive CT response to NaCl and no sensitivity to ethanol. We conclude that ethanol increases salt taste sensitivity by its direct action on the Bz-insensitive VR-1 variant salt taste receptor...
  39. ncbi Aerobic biotransformation of 4-fluorocinnamic acid to 4-fluorobenzoic acid
    L M dos Santos
    Environmental Research Laboratory, Analytical Sciences, SmithKline Beecham Pharmaceuticals, Harlow, UK
    Biodegradation 12:23-9. 2001
    ..The removal of FCA up to 200 mg L(-1) followed first order kinetics. The half-lives for removal of FCA from the test solutions supplied with 200 mg L(-1), 100 mg L(-1), and 50 mg L(-1) were 53, 18, and 5 hours respectively...
  40. ncbi Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents
    Yin Luo
    State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People s Republic of China
    Bioorg Med Chem 19:4730-8. 2011
    ..Based on the preliminary results, compound 10c with potent inhibitory activity in tumor growth may be a potential anticancer agent...
  41. ncbi Salubrinal promotes healing of surgical wounds in rat femurs
    Ping Zhang
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, SL220, 723 West Michigan Street, Indianapolis, IN, 46202, USA
    J Bone Miner Metab 30:568-79. 2012
    ..In summary, the results herein demonstrate that subcutaneous administration of salubrinal accelerates healing of surgically generated bone holes through the modulation of eIF2α phosphorylation...
  42. ncbi Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection
    R Alvarez-Román
    Centre interuniversitaire de recherche et d enseignement, Pharmapeptides, Universities of Geneva and Lyon, 74166 Archamps, France
    Eur J Pharm Biopharm 52:191-5. 2001
    ..The OMC-nanocapsules provided partial protection against UV-induced erythema, in a manner significantly better than a conventional gel...
  43. ncbi Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biol Pharm Bull 26:1057-9. 2003
    ..Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin...
  44. ncbi Effect of rosmarinic acid on experimental diabetic nephropathy
    Wang Lin Jiang
    School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, China
    Basic Clin Pharmacol Toxicol 110:390-5. 2012
    ..These results suggest that RA exerts an early renal protective role to DN. Inhibition of CTGF may be a potential target in DN therapy, which highlights the possibility of using RA in the treatment of DN...
  45. ncbi Antileishmanial efficacy of fluconazole and miltefosine in combination with an immunomodulator--picroliv
    Nishi Shakya
    Division of Parasitology, Central Drug Research Institute CSIR, Chattar Manzil Palace, M G Road, Lucknow, 226001, Uttar Pradesh, India
    Parasitol Res 108:793-800. 2011
    ..Upregulation of cell-mediated immunity was also observed in animals of this group which strengthens the immunomodulatory role of picroliv. These findings suggest a new option for antileishmanial chemotherapy at lower cost and toxicity...
  46. pmc Complete biodegradation of 4-fluorocinnamic acid by a consortium comprising Arthrobacter sp. strain G1 and Ralstonia sp. strain H1
    Syed A Hasan
    Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, Netherlands
    Appl Environ Microbiol 77:572-9. 2011
    ..Degradation of 4-fluorobenzoic acid by strain H1 proceeded via 4-fluorocatechol, which was converted by an ortho-cleavage pathway...
  47. ncbi Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 1001 8308, Japan
    J Oleo Sci 59:273-80. 2010
    ..acetate (1a), beta-amyrin acetate (2a), lupeol acetate (3a), and butyrospermol acetate (4a), and four triterpene cinnamates, alpha-amyrin cinnamate (1c), beta-amyrin cinnamate (2c), lupeol cinnamate (3c), and butyrospermol cinnamate (4c)..
  48. ncbi The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: structure-activity relationships and retinoid receptor-independent anticancer activities
    Marcia I Dawson
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mini Rev Med Chem 10:455-91. 2010
    ..Structure-activity relationships and potential for clinical translation as anticancer therapeutics are presented...
  49. ncbi Effect of altitude on picroside content in core collections of Picrorhiza kurrooa from the north western Himalayas
    Meenu Katoch
    Biotechnology Department, Indian Institute of Integrative Medicine, Jammu, India
    J Nat Med 65:578-82. 2011
    ..The study concludes that picroside I and II accumulation depends on altitude, which could help in the selection and collection of superior genotypes with uniform effects for utilization by the pharmaceutical industry...
  50. ncbi Epigenetic regulation of cardiac muscle-specific genes in H9c2 cells by Interleukin-18 and histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide
    Gipsy Majumdar
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Cell Biochem 312:47-60. 2008
    ....
  51. ncbi Comparative studies of the influence of cyclodextrins on the stability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate
    Santo Scalia
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, via Fossato di Mortara 17, 44100, Ferrara, Italy
    J Pharm Biomed Anal 30:1181-9. 2002
    ..Therefore, the complex of beta-CD with trans-EHMC enhances the chemical- and photo-stability of the sunscreen agent. Moreover, it limits adverse interactions of the UV filter with other formulation ingredients...
  52. pmc Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy
    Gipsy Majumdar
    Department of Veterans Affairs Medical Center, University of Tennessee Health Science Center, Memphis, TN 38104, USA
    Physiol Genomics 43:1319-33. 2011
    ..Evidently, both TSA and CBHA caused a two- to fourfold induction of phosphatase and tensin homolog expression to counteract IL-18-induced proinflammatory signaling and cardiac hypertrophy...
  53. pmc Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway
    Xiumei Huang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian, China
    Neurobiol Aging 33:1007.e9-17. 2012
    ..This study also suggests that modulation of Aβ-induced NF-κB activation could be a potential therapeutic strategy for Alzheimer's disease...
  54. ncbi Picroliv modulates antioxidant status and down-regulates AP1 transcription factor after hemorrhage and resuscitation
    Pankaj Seth
    Center for Combat Casualty Care and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814, USA
    Shock 19:169-75. 2003
    ..These findings suggest that picroliv has the potential to be developed as a protective agent against H/R injury...
  55. pmc Osteoporosis regulation by salubrinal through eIF2α mediated differentiation of osteoclast and osteoblast
    Long He
    Korea Research Institute of Bioscience and Biotechnology KRIBB, Korea
    Cell Signal 25:552-60. 2013
    ..In addition, modulation of ATF4 and NFATc1 expressions through eIF2α phosphorylation could be a valuable target for the treatment of osteoporosis...
  56. ncbi Influence of Transcutol CG on the skin accumulation and transdermal permeation of ultraviolet absorbers
    Donald A Godwin
    University of New Mexico Health Sciences Center, College of Pharmacy, 2502 Marble NE, Albuquerque, NM 87131, USA
    Eur J Pharm Biopharm 53:23-7. 2002
    ..The results of this study demonstrate that the inclusion of Transcutol CG in sunscreen formulations increases the skin accumulation of the UV absorbers oxybenzone and cinnamate without a concomitant increase in transdermal permeation...
  57. ncbi Identification and effects of interaction phytotoxic compounds from exudate of Cistus ladanifer leaves
    N Chaves
    Department of Ecology, Faculty of Science, University of Extremadura, 06080 Badajoz, Spain
    J Chem Ecol 27:611-21. 2001
    ..When hydroxycinnamic acid and cinnamic acid were added to these mixtures there was an enhancement in the phytotoxic activity, accentuating the effect of the other allelochemicals...
  58. ncbi Picroliv, the iridoid glycoside fraction of Picrorhiza kurroa, selectively augments human T cell response to mycobacterial protein antigens
    S Sinha
    Division of Membrane Biology, Central Drug Research Institute, Lucknow, India
    Immunopharmacol Immunotoxicol 20:579-88. 1998
    ..The selective, antigen specific augmentation of human T cell response suggests that Picroliv could be useful as an adjunct to chemotherapy or as a short term prophylactic agent...
  59. ncbi Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory
    V Exarchou
    Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina GR 45110, Greece
    J Agric Food Chem 50:5294-9. 2002
    ..This deshielding may be attributed to the strong intramolecular six-membered ring hydrogen bond of the OH(5)...CO(4) moiety...
  60. ncbi In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis
    Gui Sheng Li
    School of Pharmacy, Yantai University, 32 Qingquan Road, Laishan District, Yantai 264003, PR China
    Phytomedicine 17:282-8. 2010
    ..These findings suggest that RA has potentially conferring antifibrogenic effects...
  61. pmc Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis
    Vivek Swarup
    National Brain Research Centre, Manesar, Haryana 122050, India
    Antimicrob Agents Chemother 51:3367-70. 2007
    ..001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 days postinfection...
  62. ncbi Inhibitory effect of picroside II on hepatocyte apoptosis
    Hua Gao
    College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    Acta Pharmacol Sin 26:729-36. 2005
    ..To investigate the influence of picroside II on hepatocyte apoptosis and its mechanism...
  63. ncbi Plant growth inhibition by cis-cinnamoyl glucosides and cis-cinnamic acid
    Syuntaro Hiradate
    Department of Biological Safety Science, National Institute for Agro Environmental Sciences, Tsukuba, Ibaraki 305 8604, Japan
    J Chem Ecol 31:591-601. 2005
    ..These findings indicate a potential role of cis-CA and its glucosides as allelochemicals for use as plant growth regulators in agricultural fields...
  64. ncbi Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model
    Naomi Osakabe
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Carcinogenesis 25:549-57. 2004
    ..Thus, we conclude that part of the anticarcinogenic effects of P.frutescens extract is due to RA via two independent mechanisms: inhibition of the inflammatory response and scavenging of reactive oxygen radicals...
  65. ncbi Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions
    Yoshimi Nakajima
    Department of Biofunctional Molecules, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Life Sci 80:370-7. 2007
    ..These findings indicate that WEP and caffeoylquinic acid derivatives have neuroprotective effects against retinal damage in vitro, and that these effects may be partly mediated via antioxidant effects...
  66. ncbi Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway
    Yong Chen
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 28:5836-45. 2008
    ..Thus, blocking TRPV1 might be a way to reduce morphine tolerance...
  67. ncbi Cinnamic acid-inhibited ribulose-1,5-bisphosphate carboxylase activity is mediated through decreased spermine and changes in the ratio of polyamines in cowpea
    Xingxue Huang
    Key Laboratory of Horticultural Plant Biology, College of Horticulture and Forestry, Huazhong Agricultural University, Wuhan 430070, China
    J Plant Physiol 167:47-53. 2010
    ..These results suggest that 0.1 mM CA inhibits RuBPC activity by decreasing the levels of endogenous free and perchloric acid soluble (PS) conjugated Spm, as well as the PAs ratio...
  68. ncbi Optimization of rosmarinic acid production by Lavandula vera MM plant cell suspension in a laboratory bioreactor
    Atanas I Pavlov
    Department of Microbial Biosynthesis and Biotechnologies, Laboratory in Plovdiv, Institute of Microbiology, Bulgarian Academy of Sciences, 26 Maritza Blvd, 4002 Plovdiv, Bulgaria
    Biotechnol Prog 21:394-6. 2005
    ..9 degrees C, where maximal yield (Y(max)) of 3489.4 mg/L of rosmarinic acid was achieved (2 times higher compared with the shake-flasks cultivation)...
  69. ncbi Rosmarinic acid induces melanogenesis through protein kinase A activation signaling
    Jongsung Lee
    Biospectrum Life Science Institute, SK Ventium 101 701, Dangjung Dong, Gunpo City, 436 776 Kyunggi do, Republic of Korea
    Biochem Pharmacol 74:960-8. 2007
    ..Rosmarinic acid-induced expression of tyrosinase protein was attenuated by H-89. Based on these results, we report for the first time that rosmarinic acid induces melanogenesis through PKA activation signaling...
  70. ncbi Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice
    Hiroshi Takeda
    Department of Pharmacology and Intractable Diseases Research Center Division of Drug Research and Devlopment, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, 160 8402, Tokyo, Japan
    Eur J Pharmacol 449:261-7. 2002
    ..These results suggest that both caffeic acid and rosmarinic acid may produce antidepressive-like activity via some mechanism(s) other than the inhibition of monoamine transporters and monoamine oxidase...
  71. ncbi Pronociceptive response elicited by TRPA1 receptor activation in mice
    E L Andrade
    Department of Pharmacology, Federal University of Santa Catarina, CCB, Campus Universitario Trindade, 88049 900, Florianopolis, SC, Brazil
    Neuroscience 152:511-20. 2008
    ..Thus, the TRPA1 receptor has an apparently relevant role in nociceptive processes and the selective TRPA1 antagonist might possess a potential antinociceptive property...
  72. ncbi Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats
    Xiaochuan Li
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    Drug Metab Dispos 35:234-9. 2007
    ..Overall, the results show that depside salts from S. miltiorrhiza are rapidly and widely distributed to tissues after intravenous administration in rats but that they are also rapidly cleared and excreted...
  73. ncbi The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity
    Teresa Iuvone
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Pharmacol Exp Ther 317:1143-9. 2006
    ..Rosmarinic acid could contribute, at least in part, for sage-induced neuroprotective effect...
  74. ncbi Modulation of carcinogenic response and antioxidant enzymes of rats administered with 1,2-dimethylhydrazine by Picroliv
    N V Rajeshkumar
    Amala Cancer Research Centre, Thrissur, Kerala 680 553, India
    Cancer Lett 191:137-43. 2003
    ..Picroliv treated liver resembled normal liver except the presence of a few degenerating cells. Renal anatomy was not altered by DMH administration...
  75. ncbi Lithospermic acid B is more responsive to silver ions (Ag+) than rosmarinic acid in Salvia miltiorrhiza hairy root cultures
    Ying Xiao
    Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People s Republic of China
    Biosci Rep 30:33-40. 2010
    ..Further intermediate monitoring and compound feeding experiments were performed to rank the strength of this hypothesis. Our study, for the first time, provides evidence that RA is a precursor leading to LAB synthesis...
  76. ncbi A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking
    John A Schmidt
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Traffic 11:1530-6. 2010
    ..Thus, PLA(2) enzymes appear to have an important role in the earliest steps of membrane tubule formation at the TGN, which are utilized for membrane trafficking...
  77. ncbi Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis
    Hyo Jung Lee
    Department of Biotechnology BK21 Program, Chosun University, Gwangju 501 759, Republic of Korea
    Toxicology 250:109-15. 2008
    ..These results suggest that RA can protect SH-SY5Y cells under oxidative stress conditions by regulating apoptotic process. Thus, RA should be clinically evaluated for the prevention of neurodegenerative diseases...
  78. pmc Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists
    P de Figueiredo
    Section of Biochemistry, Molecular, and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 10:1763-82. 1999
    ..In addition, they implicate a role for cytoplasmic PLA2 enzymes in mediating these membrane trafficking events...
  79. ncbi Antiapoptotic and antioxidant effects of rosmarinic acid in astrocytes
    L P Gao
    School of Life Sciences, Lanzhou University, Lanzhou Medical College, P R China
    Pharmazie 60:62-5. 2005
    ..Results clearly show that RA was able to attenuate H2O2-induced cell injury by its antiapoptotic and antioxidant activity...
  80. ncbi Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction
    Fabio K Ticli
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, FCFRP, Universidade de Sao Paulo, USP, Ribeirao Preto SP, Brazil
    Toxicon 46:318-27. 2005
    ..CD data presented here suggest that, after binding, no significant conformation changes occur either in the Cv-RA or in the target PLA2. A possible model for the interaction of rosmarinic acid with Lys49-PLA2 BthTX-I is proposed...
  81. ncbi Beneficial effects of rosmarinic acid on suppression of collagen induced arthritis
    Jeehee Youn
    Department of Anatomy and Cell Biology and Institute of Biomedical Science, College of Medicine, Hanyang University, Seoul, Korea
    J Rheumatol 30:1203-7. 2003
    ..To assess the therapeutic potential of rosmarinic acid (RosA) in an inflammatory autoimmune arthritis model...
  82. pmc Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis
    Preetha Anand
    Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:8861-70. 2008
    ..Suppression of these proteins enhanced apoptosis induced by TNF. Overall, our results show that picroliv inhibits the NF-kappaB activation pathway, which may explain its anti-inflammatory and anticarcinogenic effects...
  83. ncbi Influence of encapsulation on the in vitro percutaneous absorption of octyl methoxycinnamate
    M M Jimenez
    Laboratory of Dermopharmacy and Cosmetology, School of Pharmacy, Claude Bernard Lyon I University, 69373 Lyon Cedex 08, France
    Int J Pharm 272:45-55. 2004
    ..The crystallinity of the polymer have the ability of reflecting and scattering UV radiation on their own thus leading to photoprotection without the need for molecular sunscreens...
  84. ncbi High efficiency poplar transformation
    Leland J Cseke
    Department of Biological Sciences, The University of Alabama in Huntsville, 142 Wilson Hall, Huntsville, AL 35899, USA
    Plant Cell Rep 26:1529-38. 2007
    ..Likewise, the fact that the protocols are amenable to high-throughput formats makes them better suited for large-scale functional genomics studies in poplars...
  85. pmc In vitro and in vivo estrogenicity of UV screens
    M Schlumpf
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Environ Health Perspect 109:239-44. 2001
    ..5% in olive oil. Our findings indicate that UV screens should be tested for endocrine activity, in view of possible long-term effects in humans and wildlife...
  86. ncbi Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes
    Jitka Psotova
    Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic
    J Photochem Photobiol B 84:167-74. 2006
    ..These results suggest that P. vulgaris and RA, used in skin care cosmetics, may offer protection against UVA-induced oxidative stress and may be beneficial as a supplement in photoprotective dermatological preparations...
  87. ncbi Production and optimisation of rosmarinic acid by Satureja hortensis L. callus cultures
    Bektas Tepe
    Cumhuriyet University, Department of Molecular Biology and Genetics, 58140 Sivas, Turkey
    Nat Prod Res 21:1133-44. 2007
    ..0% (w/v) sucrose. According to the experiments carried out with the wild S. hortensis, it is found to have 25.02+/-1.21 mg g(-1) rosmarinic acid. No differentiation was observed in any callus during the course of this study...
  88. pmc Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. I. Effect on TRC volume and Na+ flux
    Vijay Lyall
    Department of Physiology, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 125:569-85. 2005
    ..We conclude that in the presence of mineral salts, ethanol modulates the Bz-insensitive VR-1 variant salt taste receptor...
  89. ncbi Establishment of Salvia officinalis L. hairy root cultures for the production of rosmarinic acid
    Izabela Grzegorczyk
    Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90 151 Lodz, Poland
    Z Naturforsch C 61:351-6. 2006
    ..The level was significantly higher than that found in untransformed root culture (19 mg g(-10 of dry wt)...
  90. ncbi Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative
    Kai Long
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
    Bioorg Med Chem Lett 15:3849-52. 2005
    ..Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification...
  91. ncbi Transepithelial transport of rosmarinic acid in intestinal Caco-2 cell monolayers
    Yutaka Konishi
    Applied Bioresearch Center, Research and Development Department, Kirin Brewery Co, Ltd, Gunma, Japan
    Biosci Biotechnol Biochem 69:583-91. 2005
    ..The potential of orally administered RA in vivo will be further investigated...
  92. ncbi Rosmarinic acid down-regulates the LPS-induced production of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) via the MAPK pathway in bone-marrow derived dendritic cells
    Hyung Keun Kim
    Department of Orthopaedics, Chonnam National University, Hwasun Hospital, Chonnam 519 809, Korea
    Mol Cells 26:583-9. 2008
    ....
  93. ncbi Antimutagenicity of rosmarinic acid in Swiss mice evaluated by the micronucleus assay
    Michelle Andrade Furtado
    Universidade de Franca, Avenida Dr Armando Salles de Oliveira, 201 Parque Universitário, 14404 600, Franca, Sao Paulo, Brazil
    Mutat Res 657:150-4. 2008
    ..Although the mechanisms underlying the protective effect of RA are not completely understood, the putative antioxidant activity of RA might explain its effect on DXR mutagenicity...
  94. ncbi Synergistic immunosuppressive effects of rosmarinic acid and rapamycin in vitro and in vivo
    Su Young Yun
    Signal Transduction Laboratory, Mogam Biotechnology Research Institute, Gyonggido, Korea
    Transplantation 75:1758-60. 2003
    ..In this study, we evaluated the ability of RosA alone and in conjunction with currently used immunosuppressive drugs to inhibit in vitro splenic T-cell proliferation and prolong skin graft survival in vivo...
  95. ncbi Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid
    Seigo Baba
    Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1, Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Life Sci 75:165-78. 2004
    ....
  96. ncbi Synergistic protective effect of picroside II and NGF on PC12 cells against oxidative stress induced by H2O2
    Yan Cao
    State Key Laboratory of Bioreactor Engineering and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, PR China
    Pharmacol Rep 59:573-9. 2007
    ..Such action supports the therapeutic potential of picroside II and NGF in treating nervous disorders based on their synergistic effect...
  97. ncbi The neuroprotective effect of picroside II from hu-huang-lian against oxidative stress
    Ting Li
    The State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, China
    Am J Chin Med 35:681-91. 2007
    ..All these results indicated that picroside II possessed the therapeutic potential in protecting against neurological injuries damaged by oxidative stress...
  98. ncbi Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2)
    C Renzulli
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    J Appl Toxicol 24:289-96. 2004
    ..Similarly, apoptosis cell death was prevented, as demonstrated by reduction of DNA fragmentation and inhibition of caspase-3 activation (P < 0.001)...
  99. ncbi Monitoring 2-ethylhexyl-4-methoxycinnamate photoisomerization on skin using attenuated total reflection fourier transform infrared spectroscopy
    P Pangnakorn
    Sensor Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    Appl Spectrosc 61:193-8. 2007
    ..No photodimerization was detected even at the extreme EHMC coverage of 4.0 mg/cm(2) after a UVB exposure of 0.90 J/cm(2)...
  100. ncbi Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells
    Ping Li
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Life Sci 71:1821-35. 2002
    ..Picrosides I and II may become selective pharmacological tools for studying the MAP kinase-dependent signaling pathway in outgrowth of neurites induced by many kinds of neuritogenic substances including bFGF...
  101. ncbi A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    Chem Senses 30:i42-3. 2005

Research Grants31

  1. Rexinoid Synergy in Prostate Cancer Apoptosis
    Marcia Dawson; Fiscal Year: 2009
    ..We anticipate that our results will provide a more effective and less systemically toxic means of enhancing the efficacy of chemotherapeutic agents currently used to treat prostate cancer. ..
  2. BENZANNULATION APPROACH TO BIARYL ETHERS
    Michael Harmata; Fiscal Year: 2001
    ..abstract_text> ..
  3. SYNTHESIS OF NATURAL PRODUCTS WITH OXAZOLE MOIETIES
    Peter Wipf; Fiscal Year: 2005
    ..The proposed program represents a multi-dimensional effort to increase the basic knowledge of the function of marine natural products, establish new methods in heterocyclic chemistry, and identify novel pharmacophores. ..
  4. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  5. NUCLEOSIDE TRANSPORT INHIBITORS FOR CANCER PREVENTION
    John Buolamwini; Fiscal Year: 2005
    ..The mechanistic insights to be gained regarding the carcinogenesis process and its abrogation may lead to the identification of novel molecular targets and agents for cancer prevention. ..
  6. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  7. Mechanical response of osteoblasts in 3D matrix
    Hiroki Yokota; Fiscal Year: 2007
    ..Completion of these studies should provide significant insight into the mechanical responses of osteoblasts in a 3D environment, and contribute to developing. q load-induced in vitro connective tissue engineering. ..
  8. Nucleoside Transporters In HAART Mitochondrial Toxicity
    John Buolamwini; Fiscal Year: 2006
    ..abstract_text> ..
  9. NBMPR-BINDING SITE OF THE HUMAN ES ADENOSINE TRANSPORTER
    John Buolamwini; Fiscal Year: 2004
    ..Biweekly research progress meetings will be held with sponsors and committee members. ..
  10. Effects of Natural Agents with Fluoride on Caries
    Hyun Koo; Fiscal Year: 2004
    ....
  11. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  12. E1A-INDUCED CELLULAR SENSITIZATION TO APOPTOSIS
    James Cook; Fiscal Year: 2002
    ..abstract_text> ..
  13. Sex Diffrerences in Opioid Antinociception
    Andrew Barrett; Fiscal Year: 2003
    ....
  14. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  15. Macrophage-Dependent Immunopathogenesis of Anthrax
    James Cook; Fiscal Year: 2003
    ..This information will be used to seem molecular interventions that reduce or abrogate the shock response to this infection. ..
  16. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  17. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  18. Pseudopteroxazole and Related Antitubercular Agents
    Michael Harmata; Fiscal Year: 2007
    ..More generally, the methodology to be developed should have extremely broad impact, as it can be applied to the generation of stereogenic centers in a large number of compounds of biological and medicinal interest. ..
  19. PROMOTER- BASED ESTIMATION ANALYSIS
    Hiroki Yokota; Fiscal Year: 2003
    ....
  20. BONE AND KNEE LOADING
    Hiroki Yokota; Fiscal Year: 2005
    ..The proposed study will contribute to development of a novel loading model to strengthen bone without causing deformation of fragile bone in the elderly. ..
  21. GENERATION OF THOMSEN-FREIDENREICH-SPECIFIC T CELLS
    Alessandra Franco; Fiscal Year: 2002
    ..Two strategies will be compared: 1) passive immunotherapy by T cell transfer with selected T cell clones; and 2) active vaccination with the glycopeptides and glycolipids to generate a TF-specific T cell response. ..
  22. Novel Agents Targeted To p53-Mdm2 Pathways
    John Buolamwini; Fiscal Year: 2004
    ..This research program is planned to involve the participation of undergraduate students for the purpose of their training in biomedical research. ..
  23. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  24. DEVELOPMENT OF NOVEL CHEMOPRVENTIVE AGENTS
    John Buolamwini; Fiscal Year: 2008
    ..The success of this project will expand our armamentarium of chemopreventive agents and uncover novel chemoprevention molecular targets. [unreadable] [unreadable] [unreadable]..
  25. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  26. BIOCHEMICAL MODEL REACTIONS
    Ronald Breslow; Fiscal Year: 2007
    ..In addition, both parts of the project will help us understand natural enzymes. [unreadable] [unreadable]..
  27. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  28. Receptor Tyrosine Kinases in Mechanotransduction
    Zheng Gen Jin; Fiscal Year: 2009
    ..In this pathway, VEGFR2 may emerge as a central mediator for laminar flow atheroprotective effects, which will provide new insight into the prevention of atherosclerotic vascular disease. ..