benzoyl peroxide

Summary

Summary: A peroxide derivative that has been used topically for burns and as a dermatologic agent in the treatment of acne and poison ivy. It is used also as a bleach in the food industry.

Top Publications

  1. ncbi A combination benzoyl peroxide and clindamycin topical gel compared with benzoyl peroxide, clindamycin phosphate, and vehicle in the treatment of acne vulgaris
    E H Tschen
    Academic Dermatology Associates, Albuquerque, New Mexico, USA
    Cutis 67:165-9. 2001
  2. ncbi Community-based trial results of combination clindamycin 1%--benzoyl peroxide 5% topical gel plus tretinoin microsphere gel 0.04% or 0.1% or adapalene gel 0.1% in the treatment of moderate to severe acne
    Leon Kircik
    Indiana University, Indianapolis, USA
    Cutis 80:10-4. 2007
  3. ncbi Combining clindamycin 1%-benzoyl peroxide 5% gel with multiple therapeutic options
    Joseph Bikowski
    Department of Dermatology, Ohio State University, Columbus, USA
    Cutis 78:13-20. 2006
  4. ncbi Solubilized benzoyl peroxide versus benzoyl peroxide/clindamycin in the treatment of moderate acne
    Emil Tanghetti
    Center for Dermatology and Laser Surgery, Sacramento, CA 95819, USA
    J Drugs Dermatol 7:534-8. 2008
  5. ncbi Benzoyl peroxide microsphere cream as monotherapy and combination treatment of acne
    Joseph Bikowski
    Ohio State University, Columbus, OH, USA
    J Drugs Dermatol 7:590-5. 2008
  6. ncbi The microsponge delivery system of benzoyl peroxide: preparation, characterization and release studies
    M Jelvehgari
    School of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
    Int J Pharm 308:124-32. 2006
  7. ncbi Antibacterial efficacy of benzoyl peroxide in phospholipid liposomes. A vehicle-controlled, comparative study in patients with papulopustular acne
    J W Fluhr
    Department of Dermatology, Karlsruhe Municipal Hospital Complex, Karlsruhe, Germany
    Dermatology 198:273-7. 1999
  8. ncbi Benzoyl peroxide: enhancing antibiotic efficacy in acne management
    Maha Dutil
    Division of Dermatology, University of Toronto, Women s College Hospital, Toronto, ON, Canada
    Skin Therapy Lett 15:5-7. 2010
  9. ncbi Comparison of a chlorhexidine and a benzoyl peroxide shampoo as sole treatment in canine superficial pyoderma
    A Loeffler
    Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, North Mymms, Hertfordshire AL9 7TA, UK
    Vet Rec 169:249. 2011
  10. ncbi Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea
    James J Leyden
    Skin Study Center, Broomall, Pennsylvania, USA
    Cutis 73:11-7. 2004

Research Grants

  1. CRITICAL CHANGES AND FACTORS IN SKIN TUMOR PROGRESSION
    John DiGiovanni; Fiscal Year: 1992
  2. MARKERS OF SKIN TUMOR PROGRESSION
    Andres Klein Szanto; Fiscal Year: 1992
  3. Modulation of Bone's Mechanical Behavior by Bone Quality
    Stefan Judex; Fiscal Year: 2010
  4. Controlled Delivery System for Naltrexone
    EMMANUEL AKALA; Fiscal Year: 2004

Detail Information

Publications232 found, 100 shown here

  1. ncbi A combination benzoyl peroxide and clindamycin topical gel compared with benzoyl peroxide, clindamycin phosphate, and vehicle in the treatment of acne vulgaris
    E H Tschen
    Academic Dermatology Associates, Albuquerque, New Mexico, USA
    Cutis 67:165-9. 2001
    A topical gel combining 5% benzoyl peroxide and 1% clindamycin as phosphate was evaluated in a 10-week randomized double-blind trial involving 287 patients with moderate to moderately severe acne...
  2. ncbi Community-based trial results of combination clindamycin 1%--benzoyl peroxide 5% topical gel plus tretinoin microsphere gel 0.04% or 0.1% or adapalene gel 0.1% in the treatment of moderate to severe acne
    Leon Kircik
    Indiana University, Indianapolis, USA
    Cutis 80:10-4. 2007
    ..The addition of benzoyl peroxide (BPO) to all long-term antibiotic treatment is widely advocated to help suppress the emergence of antibiotic-..
  3. ncbi Combining clindamycin 1%-benzoyl peroxide 5% gel with multiple therapeutic options
    Joseph Bikowski
    Department of Dermatology, Ohio State University, Columbus, USA
    Cutis 78:13-20. 2006
    ..on recent studies and case reports that evaluated the stability, tolerability, and efficacy of clindamycin 1%-benzoyl peroxide 5% tube gel in combination with topical retinoids and oral antibiotics...
  4. ncbi Solubilized benzoyl peroxide versus benzoyl peroxide/clindamycin in the treatment of moderate acne
    Emil Tanghetti
    Center for Dermatology and Laser Surgery, Sacramento, CA 95819, USA
    J Drugs Dermatol 7:534-8. 2008
    b>Benzoyl peroxide (BPO) is poorly soluble. A solubilized formulation of BPO has been developed to maximize its bioavailability and enhance follicular penetration.
  5. ncbi Benzoyl peroxide microsphere cream as monotherapy and combination treatment of acne
    Joseph Bikowski
    Ohio State University, Columbus, OH, USA
    J Drugs Dermatol 7:590-5. 2008
    This office-based case series describes the use of a new formulation of benzoyl peroxide (BPO) delivered via a porous microsphere cream vehicle in patients with mild to moderate acne vulgaris...
  6. ncbi The microsponge delivery system of benzoyl peroxide: preparation, characterization and release studies
    M Jelvehgari
    School of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
    Int J Pharm 308:124-32. 2006
    b>Benzoyl peroxide (BPO) is commonly used in topical formulations for the treatment of acne and athletes foot...
  7. ncbi Antibacterial efficacy of benzoyl peroxide in phospholipid liposomes. A vehicle-controlled, comparative study in patients with papulopustular acne
    J W Fluhr
    Department of Dermatology, Karlsruhe Municipal Hospital Complex, Karlsruhe, Germany
    Dermatology 198:273-7. 1999
    ..Literature reports indicate that phospholipid liposomes facilitate the accumulation of active agents in the infundibulum...
  8. ncbi Benzoyl peroxide: enhancing antibiotic efficacy in acne management
    Maha Dutil
    Division of Dermatology, University of Toronto, Women s College Hospital, Toronto, ON, Canada
    Skin Therapy Lett 15:5-7. 2010
    b>Benzoyl peroxide is one of the most widely used topical agents for acne. It has potent antibacterial and mild anti-inflammatory and comedolytic effects...
  9. ncbi Comparison of a chlorhexidine and a benzoyl peroxide shampoo as sole treatment in canine superficial pyoderma
    A Loeffler
    Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, North Mymms, Hertfordshire AL9 7TA, UK
    Vet Rec 169:249. 2011
    ..5 per cent benzoyl peroxide shampoo (Paxcutol; Virbac) in 22 dogs with superficial pyoderma...
  10. ncbi Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea
    James J Leyden
    Skin Study Center, Broomall, Pennsylvania, USA
    Cutis 73:11-7. 2004
    ..from a randomized, double-blind, vehicle-controlled, 12-week study that assessed the efficacy of topical benzoyl peroxide 5%/clindamycin 1% (BP/C) gel (BenzaClin) versus vehicle in the treatment of rosacea...
  11. ncbi Determination of benzoyl peroxide, as benzoic acid, in wheat flour by capillary electrophoresis compared with HPLC
    Guangfen Mu
    Department of Applied Chemistry, Yantai University, Yantai, PR China
    J Sci Food Agric 92:960-4. 2012
    In recent years, debate on the addition of benzoyl peroxide (BP) to wheat flour has increased in China...
  12. ncbi A randomized, parallel, vehicle-controlled comparison of two erythromycin/benzoyl peroxide preparations for acne vulgaris
    Diane Thiboutot
    Pennsylvania State University College of Medicine, Hershey, USA
    Clin Ther 24:773-85. 2002
    Topical erythromycin/benzoyl peroxide (EBP), marketed for acne treatment, must be compounded by a pharmacist and requires subsequent refrigeration, warranting the development of alternate formulations.
  13. ncbi Improved one-pot synthesis of styryl tetrahydrofurans and cyclohexanes by radical addition to beta-nitrostyrenes in the presence of benzoyl peroxide
    Yeong Jiunn Jang
    Department of Chemistry, National Taiwan Normal University, 88, Sec 4, Tingchow Road, Taipei, 116 Taiwan, Republic of China
    Chemistry 9:2123-8. 2003
    ..of heterocycles or cyclohydrocarbons units to (E)-beta-nitrostyrenes 1 using a common radical initiator benzoyl peroxide. High reactivity and selectivity with wide substrate scope were attained by using this easy methodology...
  14. ncbi Factors affecting the morphology of benzoyl peroxide microsponges
    Ali Nokhodchi
    Chemistry and Drug Delivery Group, Medway School of Pharmacy, Universities of Kent and Greenwich, Central Avenue, Anson Building, Chatham Maritime, Kent ME4 4TB, UK
    Micron 38:834-40. 2007
    b>Benzoyl peroxide (BPO) is primarily used in the treatment of mild to moderate acne. However, its application is associated with skin irritation...
  15. ncbi Amperometric detection of benzoyl peroxide in pharmaceutical preparations using carbon paste electrodes with peroxidases naturally immobilized on coconut fibers
    J V B Kozan
    Departamento de Quimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Biosens Bioelectron 25:1143-8. 2010
    ..The new sensor was applied for the amperometric quantification of benzoyl peroxide in facial creams and dermatological shampoos. The amperometric measurements were performed in 0...
  16. ncbi Simple and fast fluorescence detection of benzoyl peroxide in wheat flour by N-methoxy rhodamine-6G spirolactam based on consecutive chemical reactions
    Wei Chen
    Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
    Anal Chim Acta 708:84-8. 2011
    b>Benzoyl peroxide (BPO) as a brightener is often added to wheat flour, and excessive use of this food additive is receiving increasing concern...
  17. ncbi Synergistic antimicrobial activity by combining an allylamine with benzoyl peroxide with expanded coverage against yeast and bacterial species
    C G Burkhart
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Br J Dermatol 154:341-4. 2006
    ..b>Benzoyl peroxide (BP), used in concert with antimicrobial agents containing an accessible tertiary amine, has previously been ..
  18. ncbi Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator-masked, controlled trial
    R Capizzi
    Clinica Dermatologica, Policlinico Universitario Agostino Gemelli, Rome, Italy
    Br J Dermatol 151:481-4. 2004
    Combination therapy with antiseptics such as benzoyl peroxide (BP) and topical retinoids is widely used as first-line treatment for acne vulgaris (AV). However, these combinations could have a suboptimal skin tolerability...
  19. ncbi Adapalene 0.1% and benzoyl peroxide 2.5% as a fixed-dose combination gel is as well tolerated as the individual components alone in terms of cumulative irritancy
    Christian Loesche
    Galderma Research and Development, 2400 Route des Colles, 06410 Biot, France
    Eur J Dermatol 18:524-6. 2008
    International guidelines recommend the combination of retinoids (e.g. adapalene, tazarotene) and benzoyl peroxide for treating acne because of their complementary mechanisms of action. A new fixed-dose combination gel of adapalene 0...
  20. ncbi Treatment of 2,453 acne vulgaris patients aged 12-17 years with the fixed-dose adapalene-benzoyl peroxide combination topical gel: efficacy and safety
    Lawrence E Eichenfield
    University of California, San Diego, USA
    J Drugs Dermatol 9:1395-401. 2010
    ..A fixed-dose combination gel of adapalene 0.1% and benzoyl peroxide 2...
  21. ncbi Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris
    Matt Sagransky
    Department of Dermatology, Wake Forest University School of Medicine, Center for Dermatology Research, Winston Salem, NC 27157 1071, USA
    Expert Opin Pharmacother 10:2555-62. 2009
    ..Topical benzoyl peroxide (BPO) is an alternative to antibiotics in the treatment of acne vulgaris.
  22. ncbi A North American study of adapalene-benzoyl peroxide combination gel in the treatment of acne
    Linda Stein Gold
    Henry Ford Health Systems, Dermatology Department, 3031 W Grand Blvd, Ste 800, Detroit, MI 48202, USA
    Cutis 84:110-6. 2009
    A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% recently has been developed for the treatment of acne vulgaris...
  23. ncbi The efficacy of adapalene-benzoyl peroxide combination increases with number of acne lesions
    Steven R Feldman
    Department of Dermatology, Wake Forest University, Winston Salem, North Carolina 22157, USA
    J Am Acad Dermatol 64:1085-91. 2011
    ..The fixed-dose adapalene 0.1%-benzoyl peroxide (BPO) 2.5% combination gel is an efficacious and safe acne treatment.
  24. ncbi Adapalene-benzoyl peroxide once-daily, fixed-dose combination gel for the treatment of acne vulgaris: a randomized, bilateral (split-face), dose-assessment study of cutaneous tolerability in healthy participants
    Philippe Andres
    Galderma Research and Development, Sophia Antipolis, France
    Cutis 81:278-84. 2008
    ..International consensus guidelines recommend the use of topical retinoids and benzoyl peroxide (BPO) for acne treatment...
  25. ncbi Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients
    H P M Gollnick
    Department of Dermatology and Venereology, Otto von Guericke Universitat Magdeburg, 39120 Magdeburg, Germany
    Br J Dermatol 161:1180-9. 2009
    ..A unique, topical, fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has recently been developed for the once-daily treatment of acne.
  26. ncbi Efficacy and safety of stabilised hydrogen peroxide cream (Crystacide) in mild-to-moderate acne vulgaris: a randomised, controlled trial versus benzoyl peroxide gel
    Massimo Milani
    R and D Mipharm, Milan, Italy
    Curr Med Res Opin 19:135-8. 2003
    b>Benzoyl peroxide (BP) is a first-line topical treatment in acne vulgaris (AV). However, its use can cause mild skin irritation and dryness...
  27. ncbi Efficacy and tolerability of a fixed combination of clindamycin phosphate (1.2%) and low concentration benzoyl peroxide (2.5%) aqueous gel in moderate or severe acne subpopulations
    Guy Webster
    Jefferson Dermatology Service, Wilmington Department of Veterans Affairs Medical Center, Wilmington, PA, USA
    J Drugs Dermatol 8:736-43. 2009
    ..Oral antibiotics are commonly prescribed for moderate or severe acne, but there may be limitations due to concerns about side effects associated with systemic treatments...
  28. ncbi Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin with benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris
    J J Leyden
    Department of Dermatology, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    Am J Clin Dermatol 2:33-9. 2001
    BACKGROUND: Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris...
  29. ncbi Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne
    Elizabeth M Seidler
    Clinical Unit for Research Trials in Skin, Massachusetts General Hospital, Boston, Massachusetts 02139, USA
    J Am Acad Dermatol 63:52-62. 2010
    Comparative efficacy of the multiple treatments containing benzoyl peroxide (BPO) and clindamycin (CL) is not established.
  30. ncbi The evolution of benzoyl peroxide therapy
    Emil Tanghetti
    Department of Dermatology, University of California, Davis, California, USA
    Cutis 82:5-11. 2008
    Since its first use in dermatology last century, benzoyl peroxide (BPO) has undergone a number of reformulations, each enhancing its efficacy, tolerability, or both...
  31. ncbi Community study of fixed-combination adapalene 0.1% and benzoyl peroxide 2.5% in acne
    Patricia A Troielli
    Argentina Epiduo Study Group, Buenos Aires, La Plata, Cordoba, Tucuman, and Santa Fe, Argentina
    Skinmed 8:17-22. 2010
    A new fixed-dose combination formulation of adapalene 0.1% and benzoyl peroxide (BPO) 2...
  32. ncbi The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product
    J J Leyden
    University of Pennsylvania Health System, Philadelphia, USA
    J Cutan Med Surg 5:37-42. 2001
    BACKGROUND: Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris...
  33. ncbi [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]
    Wolf Ingo Worret
    Department of Dermatology and Venereology, Technical University of Munich, Germany
    J Dtsch Dermatol Ges 4:293-300. 2006
    b>Benzoyl peroxide (BPO) was introduced in the treatment of acne in 1934. Despite the fact that only few randomized trials have been published, BPO is considered the standard in topical acne treatment...
  34. ncbi Photocarcinogenesis and toxicity of benzoyl peroxide in hairless mice after simulated solar radiation
    Catharina M Lerche
    Department of Dermatology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
    Exp Dermatol 19:381-6. 2010
    Topical benzoyl peroxide (BPO) gel has long been used to treat acne vulgaris and has recently been combined with clindamycin (BPO-clin)...
  35. ncbi Benzoyl peroxide/clindamycin/UVA is more effective than fluticasone/UVA in progressive macular hypomelanosis: a randomized study
    Germaine N Relyveld
    Netherlands Institute for Pigment Disorders, Amsterdam, The Netherlands
    J Am Acad Dermatol 55:836-43. 2006
    ..There is no effective treatment for progressive macular hypomelanosis. Recent findings indicate that Propionibacterium acnes may play a role in the pathogenesis...
  36. ncbi Effect of benzoyl peroxide on antioxidant status, NF-kappaB activity and interleukin-1alpha gene expression in human keratinocytes
    G Valacchi
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Toxicology 165:225-34. 2001
    b>Benzoyl peroxide (BP) is used as a topical treatment for acne. Besides its anti-bacterial activity, the exact molecular mechanisms underlying its mode of action are not fully understood...
  37. ncbi Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study
    Diane M Thiboutot
    The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    J Am Acad Dermatol 57:791-9. 2007
    A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for the once-daily treatment of acne.
  38. ncbi 13-cis Retinoic acid ameliorates benzoyl peroxide-induced oxidative stress and hyperproliferative response in murine skin: a chemopreventive study
    Sarwat Sultana
    Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, New Delhi 110062, India
    Cancer Detect Prev 28:200-7. 2004
    The present paper assesses the chemopreventive potential of retinoic acid on benzoyl peroxide (BPO)-induced cutaneous tumor promotion response and oxidative stress in murine skin...
  39. ncbi Effect of alpha-tocopherol and N-acetylcysteine on benzoyl peroxide toxicity in human keratinocytes
    Elisa Bellei
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    J Biochem Mol Toxicol 18:107-14. 2004
    b>Benzoyl peroxide is a free-radical generating compound widely used in the polymer industry and also in pharmaceuticals as antimicrobial agent to treat acne...
  40. ncbi The effect of benzoyl peroxide and benzoyl peroxide/erythromycin combination on the antioxidative defence system in papulopustular acne
    Pinar Y Basak
    Department of Dermatology, Suleyman Demirel University Faculty of Medicine, 32100 Isparta, Turkey
    Eur J Dermatol 12:53-7. 2002
    ..b>Benzoyl peroxide (BP) and BP combination with erythromycin (BP/E) are effective topical medications for the treatment of mild ..
  41. ncbi An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: assessment of efficacy and safety in 2813 patients
    Diane Thiboutot
    Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Am Acad Dermatol 59:792-800. 2008
    We sought to evaluate efficacy, safety, and tolerability of a combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% (clindamycin-BPO 2.5%) aqueous gel in moderate to severe acne vulgaris.
  42. ncbi Modulatory effect of gentisic acid on the augmentation of biochemical events of tumor promotion stage by benzoyl peroxide and ultraviolet radiation in Swiss albino mice
    Sonia Sharma
    Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    Toxicol Lett 153:293-302. 2004
    ..b>Benzoyl peroxide (BPO) (20 mg/0.2 ml/animal) and ultraviolet radiations (UVR) (0...
  43. ncbi Alpha-tocopherol amplifies benzoyl peroxide free radical decomposition in a chemical system
    Cristina Rota
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Free Radic Res 40:637-45. 2006
    b>Benzoyl peroxide is commonly used in the treatment of acne, even though some adverse effects have been reported, probably mediated by the formation of peroxide-derived free radicals and the depletion of antioxidants...
  44. ncbi A randomized, double-blind comparison of a clindamycin phosphate/benzoyl peroxide gel formulation and a matching clindamycin gel with respect to microbiologic activity and clinical efficacy in the topical treatment of acne vulgaris
    William J Cunliffe
    Department of Dermatology, The General Infirmary, Leeds, United Kingdom
    Clin Ther 24:1117-33. 2002
    ..One approach to suppressing the overgrowth of antibiotic-resistant bacteria is to develop combination products composed of active constituents with complementary but distinct mechanisms of antibacterial action...
  45. ncbi Site-specific oxidation at GG and GGG sequences in double-stranded DNA by benzoyl peroxide as a tumor promoter
    S Kawanishi
    Department of Hygiene, Mie University School of Medicine, Japan
    Biochemistry 38:16733-9. 1999
    b>Benzoyl peroxide (BzPO), a free-radical generator, has tumor-promoting activity...
  46. ncbi Benzoyl peroxide, adapalene, and their combination in the treatment of acne vulgaris
    Caner Korkut
    Trakya University, Faculty of Medicine, Department of Dermatology, Edirne, Turkey
    J Dermatol 32:169-73. 2005
    b>Benzoyl peroxide and adapalene are among the most effective topical agents used in the treatment of acne...
  47. ncbi Effect of topical benzoyl peroxide/clindamycin versus topical clindamycin and vehicle in the reduction of Propionibacterium acnes
    James J Leyden
    Department of Dermatology, University of Pennsylvania School of Medicine and Hospital of the University of Pennsylvania, Philadelphia 19104 4283, USA
    Cutis 69:475-80. 2002
    ..The onset of action and effectiveness of 3 topical preparations (benzoyl peroxide 5%/clindamycin phosphate 1% gel, clindamycin phosphate 1% solution, and vehicle gel) in reducing P acnes were ..
  48. ncbi [Management of acne in adolescents]
    M Faure
    Service de Dermatologie, Hopital Edouard Herriot, Pavillon R, 5, Place d Arsonval, 69437 Lyon Cedex 03, France
    Arch Pediatr 14:1152-6. 2007
    ..Acne has to be treated according to the type of acne, severity, age and sex. Acne may also be the major sign of ovarian (PCOS) or adrenal hyperandrogenism in either female teenagers or both sexes, respectively...
  49. ncbi Tazarotene versus tazarotene plus clindamycin/benzoyl peroxide in the treatment of acne vulgaris: a multicenter, double-blind, randomized parallel-group trial
    Emil Tanghetti
    Department of Dermatology, University of California at Davis, Sacramento, USA
    J Drugs Dermatol 5:256-61. 2006
    ..randomized, parallel-group trial has been performed to evaluate whether the adjunctive use of clindamycin/benzoyl peroxide could enhance the efficacy of tazarotene still further...
  50. ncbi Acne: improving skin and self-esteem
    Jonette E Keri
    University of Miami, Miller School of Medicine, FL, USA
    Pediatr Ann 35:174-9. 2006
    ..Obvious physical benefits will result, but psychosocial improvements also may occur...
  51. ncbi The clinical impact of vehicle technology using a patented formulation of benzoyl peroxide 5%/clindamycin 1% gel: comparative assessments of skin tolerability and evaluation of combination use with a topical retinoid
    James Q Del Rosso
    Department of Dermatology, University of Nevada School of Medicine, Las Vegas, NV, USA
    J Drugs Dermatol 5:160-4. 2006
    ..improved formulations containing active ingredients known to produce irritation in some patients, such as benzoyl peroxide (BP) and topical retinoids...
  52. ncbi New developments in topical antimicrobial therapy for acne
    James Leyden
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Drugs Dermatol 7:s8-11. 2008
    b>Benzoyl peroxide (BPO) has been an important component of the acne treatment armamentarium for decades...
  53. ncbi Conjoint analysis: a novel, rigorous tool for determining patient preferences for topical antibiotic treatment for acne. A randomised controlled trial
    N Kellett
    Strakan Ltd, Buckholm Mill, Galashiels, UK
    Br J Dermatol 154:524-32. 2006
    ..Compliance might be enhanced by considering patient preferences for acne medications. Conjoint analysis is well suited for the study of patient preferences in healthcare, but is novel to the field of dermatology...
  54. ncbi Clindamycin/benzoyl peroxide gel (BenzaClin): a review of its use in the management of acne
    Kate McKeage
    Wolters Kluwer Health Adis, Auckland, New Zealand, an editorial office of Wolters Kluwer Health, Conshohocken, Pennsylvania, USA
    Am J Clin Dermatol 9:193-204. 2008
    Clindamycin 1%/benzoyl peroxide 5% (BenzaClin) is a combination gel indicated for use twice daily, or as directed by a physician, for the topical treatment of inflammatory and noninflammatory lesions of acne vulgaris...
  55. ncbi Practical considerations in acne treatment and the clinical impact of topical combination therapy
    Andrew C Krakowski
    Rady Children s Hospital, San Diego, California, USA
    Pediatr Dermatol 25:1-14. 2008
    ....
  56. ncbi [Treatment of acne]
    Ole Fyrand
    Hudavdelingen, Rikshospitalet, 0027 Oslo
    Tidsskr Nor Laegeforen 125:3108-9. 2005
  57. ncbi [Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies]
    Harald P M Gollnick
    Univ Hautklinik Magdeburg
    J Dtsch Dermatol Ges 2:841-7. 2004
    ..A new non-alcoholic hydrogel formulation containing 15% azelaic acid was clinically tested against two standard drugs--5% benzoyl peroxide (BPO) and 1% clindamycin.
  58. ncbi Clindamycin phosphate 1.2%- tretinoin 0.025% gel: vehicle characteristics, stability, and tolerability
    James Q Del Rosso
    Valley Hospital Medical Center, Las Vegas, Nevada, USA
    Cutis 81:405-8. 2008
    ..This article reviews important vehicle characteristics of the combination gel as well as formulation stability and tolerability data that are potentially clinically relevant...
  59. ncbi Therapeutic studies with a new combination benzoyl peroxide/clindamycin topical gel in acne vulgaris
    C N Ellis
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, USA
    Cutis 67:13-20. 2001
    ..severe acne vulgaris to evaluate the efficacy and safety of a new combination gel that stably combines 5% benzoyl peroxide and 1% clindamycin...
  60. ncbi Pharmacotherapy of acne
    Klaus Degitz
    Ludwig Maximilian University, Department of Dermatology and Allergology, Munich, Germany
    Expert Opin Pharmacother 9:955-71. 2008
    ..Recently, it has become clear that inflammatory events are important not only in the course, but also in the initiation of the disease...
  61. ncbi Current options for the topical treatment of acne vulgaris
    J S Weiss
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatr Dermatol 14:480-8. 1997
    ..Some studies indicate that several of these agents are associated with less skin irritation than previous formulations while they retain potent comedolytic activity. Adapalene also possesses significant anti-inflammatory activity...
  62. ncbi Management of truncal acne vulgaris: current perspectives on treatment
    James Q Del Rosso
    Department of Dermatology, University of Nevada School of Medicine, Las Vegas, USA
    Cutis 77:285-9. 2006
    ..This article discusses clinical challenges related to the management of truncal acne vulgaris, a system for rating disease severity, and recommendations regarding the use of topical and systemic therapies...
  63. ncbi A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide (Duac) and erythromycin + zinc acetate (Zineryt) in the treatment of mild to moderate facial acne vulgaris
    A Langner
    Department of Dermatology, Warsaw Medical University, Warsaw, Poland
    J Eur Acad Dermatol Venereol 21:311-9. 2007
    ..Antibiotics are often combined with other agents to provide topical acne treatments that are effective against both inflammatory and non-inflammatory lesions and minimize the development of antibiotic resistance...
  64. ncbi Study results of benzoyl peroxide 5%/clindamycin 1% topical gel, adapalene 0.1% gel, and use in combination for acne vulgaris
    James Q Del Rosso
    University of Nevada School of Medicine, Touro University College of Osteopathic Medicine, Las Vegas, NV, USA
    J Drugs Dermatol 6:616-22. 2007
    ..The combination of topical benzoyl peroxide and clindamycin gel has been shown to be more effective than either agent alone...
  65. ncbi A randomized, open-label, comparative study of oral doxycycline 100 mg vs. 5% topical benzoyl peroxide in the treatment of mild to moderate acne vulgaris
    N G Mareledwane
    Int J Dermatol 45:1438-9. 2006
  66. ncbi The impact and importance of resistance
    Emil Tanghetti
    Department of Dermatology, University of California, Davis, USA
    Cutis 80:5-9. 2007
    ..Most important is the use of combination therapy with benzoyl peroxide (BPO) to help minimize the development of resistance...
  67. ncbi Managing acne vulgaris effectively
    Greg Goodman
    Department of Community Medicine, Monash University, Victoria
    Aust Fam Physician 35:705-9. 2006
    ..Effective management of acne often requires using a combination of treatments that act on different parts of the pathogenic process of acne development...
  68. ncbi Cumulative irritancy comparison of topical retinoid and antimicrobial combination therapies
    Jonathan S Dosik
    TKL Research, Inc, Paramus, NJ 07652, USA
    Skinmed 5:219-23. 2006
    ..Therefore, the selection of a combination regimen should include a careful consideration of the irritation potential of the individual acne medications...
  69. ncbi Utilizing combination therapy for ethnic skin
    Susan C Taylor
    College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Cutis 80:15-20. 2007
    ..All subjects received combination clindamycin 1%-benzoyl peroxide (BPO) 5% topical gel containing glycerin and dimethicone...
  70. ncbi Combination topical therapy in the treatment of acne
    James Q Del Rosso
    Department of Dermatology, University of Nevada School of Medicine, Las Vegas, USA
    Cutis 78:5-12. 2006
    ..topical retinoids (ie, adapalene, tazarotene, tretinoin), antimicrobial and antibacterial agents (ie, benzoyl peroxide, clindamycin, erythromycin, sulfacetamide with or without sulfur), oral antibiotics (ie, doxycycline, ..
  71. ncbi A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris
    A Langner
    Department of Dermatology, il Koszykowa 82a, Warsaw Medical University and Zespol Naukowo Badawczy, Iwolang, Plac Karola I Jozefa 3, Iwonicz Zdroj, Poland
    Br J Dermatol 158:122-9. 2008
    ..Retinoids and associated treatments also have anti-inflammatory activity and decrease microcomedo formation. To date, few direct comparisons of these different acne treatments have been conducted...
  72. ncbi Emerging topical antimicrobial options for mild-to-moderate acne: a review of the clinical evidence
    James Del Rosso
    Valley Hospital Medical Center, Las Vegas, NV, USA
    J Drugs Dermatol 7:s2-7. 2008
    ..Agents with antibacterial activity (eg, benzoyl peroxide and clindamycin), reduce counts of Propionibacterium acnes, while also decreasing the numbers of inflammatory ..
  73. ncbi Acne: topical treatment
    Andrea Krautheim
    Department of Dermatology and Venerology, Otto von Guericke University, Leipzoger Strasse 44, D 39120 Magdeburg, Germany
    Clin Dermatol 22:398-407. 2004
    ..Concomitantly and subsequently, colonization with Propionibacterium acnes increases, followed by induction of inflammatory reactions from bacteria, ductal corneocytes, and sebaceous proinflammatory agents (Fig 1).(2-5)..
  74. ncbi Optimizing the use of tazarotene for the treatment of facial acne vulgaris through combination therapy
    Zoe Diana Draelos
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cutis 69:20-9. 2002
    ..compare the efficacy and tolerability of tazarotene monotherapy with 3 combination regimens--tazarotene plus benzoyl peroxide gel, tazarotene plus erythromycin/benzoyl peroxide gel, and tazarotene plus clindamycin phosphate lotion...
  75. ncbi Topical treatment for the inflamed lesion in acne, rosacea, and pseudofolliculitis barbae
    James J Leyden
    Skin Study Center, Broomall, Pennsylvania, USA
    Cutis 73:4-5. 2004
  76. ncbi Clindoxyl gel for the treatment of acne vulgaris
    J K L Tan
    University of Western Ontario, Windsor, Ontario, Canada
    Skin Therapy Lett 7:1-2. 2002
    Clindoxyl Gel (Stiefel) is a combination of 1% clindamycin phosphate and 5% benzoyl peroxide in a gel vehicle that is well tolerated and more efficacious than either active agent alone or the vehicle in reducing lesion counts and ..
  77. ncbi Acne vulgaris: one treatment does not fit all
    Sharon J Longshore
    Department of Dermatology, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 70:670, 672-4, 677-8 passim. 2003
    ..Most mild-to-moderate cases can be treated with a benzoyl peroxide product, a topical or oral antibiotic, a topical retinoid, or a combination of these medications...
  78. ncbi A randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center and the University of Toronto, Toronto, Ontario, Canada
    J Cutan Med Surg 7:31-7. 2003
    Combination treatments for acne vulgaris, such as Benzamycin (3% erythromycin/5% benzoyl peroxide) and Stievamycin (0...
  79. ncbi New therapy update--A unique combination formulation in the treatment of inflammatory acne
    Denise S Fagundes
    Stiefel International Research and Development, Sao Paulo, Brazil
    Cutis 72:16-9. 2003
    Duac Topical Gel (clindamycin 1%-benzoyl peroxide 5%) is a uniform, aqueous gel manufactured under the US Food and Drug Administration (FDA) Current Good Manufacturing Practice (cGMP) regulations and controls, which ensure that consistent ..
  80. ncbi Current concepts of the pathogenesis of acne: implications for drug treatment
    Harald Gollnick
    University Clinic for Dermatology and Venereology, Otto von Guericke University, Magdeburg, Germany
    Drugs 63:1579-96. 2003
    ..Combination therapy using retinoids plus benzoyl peroxide or antibacterials can treat existing acne lesions faster than the individual agents alone and can also ..
  81. ncbi Management of acne
    David C Liao
    Naval Hospital, Camp Pendleton, Irvine, CA, USA
    J Fam Pract 52:43-51. 2003
    ..The relative effectiveness of several topical and systemic agents has been established in clinical trials, making possible an algorithm of specific treatment decisions based on acne classification...
  82. ncbi The BEST study: results according to prior treatment
    David Rodriguez
    Dadeland Dermatology Group, Miami, Florida, USA
    Cutis 71:27-34. 2003
    ..Recently, the BenzaClin (benzoyl peroxide/ clindamycin topical gel) Efficacy and Satisfaction Trial (BEST) was conducted...
  83. ncbi A review of the use of combination therapies for the treatment of acne vulgaris
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
    J Am Acad Dermatol 49:S200-10. 2003
    ..Retinoids can also be used alone for long-term maintenance to prevent the reemergence of comedones and inflammatory acne lesions and to spare the use of antibiotics, thus helping to reduce the risk of bacterial resistance...
  84. ncbi Implications of the BEST study
    Joel Shavin
    Gwinnett Clinical Research Center, Sneliville, Georgia, USA
    Cutis 71:35-6. 2003
  85. ncbi Topical acne drugs: review of clinical properties, systemic exposure, and safety
    Arash Akhavan
    The Mount Sinai School of Medicine, Department of Dermatology, New York, NY, USA
    Am J Clin Dermatol 4:473-92. 2003
    ..b>Benzoyl peroxide, salicylic acid, sulfur, and sodium sulfacetamide are available in concentrations of 2% or more in over-the-..
  86. ncbi Compared efficacy and safety of tretinoin 0.1% microsphere gel alone and in combination with benzoyl peroxide 6% cleanser for the treatment of acne vulgaris
    Alan R Shalita
    Department of Dermatology, State University of New York, Health Science Center at Brooklyn, USA
    Cutis 72:167-72. 2003
    Our purpose was to evaluate the efficacy and safety of a combination of benzoyl peroxide 6% cleanser and tretinoin 0.1% microsphere gel versus monotherapy with tretinoin 0.1% microsphere gel...
  87. ncbi Guidelines for the management of acne vulgaris in adolescents
    Victoria Goulden
    Dermatology Department, Leeds General Infirmary, Leeds, UK
    Paediatr Drugs 5:301-13. 2003
    ..Mild acne generally requires topical treatment only. Benzoyl peroxide, azelaic acid, and antibacterials are generally used for inflammatory lesions...
  88. ncbi Preliminary results of a nonrandomized, multicenter, open-label study of patient satisfaction after treatment with combination benzoyl peroxide/clindamycin topical gel for mild to moderate acne
    Jonathan W Weiss
    Gwinnett Clinical Research Center, Sneliville, Georgia, USA
    Clin Ther 24:1706-17. 2002
    ..Assessments of patient satisfaction are needed to determine treatment-related improvement in acne from the patient's perspective...
  89. ncbi Topical tazarotene: The BEST (balancing efficacy, speed, and tolerability) in acne trial
    Alan Shalita
    Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, USA
    Cutis 74:4-8. 2004
    ..The combination of tazarotene 0.1% cream and clindamycin-benzoyl peroxide was the best tolerated of all the treatment regimens...
  90. ncbi Clindamycin/benzoyl peroxide gel: a review of its use in the management of acne
    Gregory T Warner
    Adis International Inc, Langhorne, Pennsylvania 19047, USA
    Am J Clin Dermatol 3:349-60. 2002
    Clindamycin/benzoyl peroxide gel has demonstrated clinical efficacy in the treatment of acne vulgaris through both antibacterial and anti-inflammatory means...
  91. ncbi [Treating acne: avoid the development of antibiotic resistance by applying topical and combined therapy]
    D Abeck
    Cutaris Zentrum, Candidplatz 11, D 81543 München
    MMW Fortschr Med 145:29. 2003
  92. ncbi Potential role for a new combination topical therapy in treating mild to moderate acne vulgaris
    E Tschen
    Academic Dermatology Associates, Albuquerque, New Mexico, USA
    Cutis 67:25-7. 2001
    ..A new gel that stably combines 5% benzoyl peroxide and 1% clindamycin has become available to treat mild to moderately severe inflammatory acne...
  93. ncbi Dermatologic signs in patients with eating disorders
    Renata Strumia
    Unit of Dermatology, University Hospital S Anna, Ferrara, Italy
    Am J Clin Dermatol 6:165-73. 2005
    ..Acne may be treated with topical benzoyl peroxide, antibacterials or azaleic acid; these agents may be administered as monotherapy or in combinations...
  94. ncbi Gateways to clinical trials
    M Bayes
    Prous Science, Barcelona, Spain
    Methods Find Exp Clin Pharmacol 28:451-95. 2006
    ..certolizumab pegol, cetuximab, CG-0070, ciclesonide, cinacalcet hydrochloride, clindamycin phosphate/benzoyl peroxide, cryptophycin 52, Cypher; Dabigatran etexilate, darapladib, darbepoetin alfa, decitabine, deferasirox, ..
  95. ncbi Systemic antibiotic therapy of acne vulgaris
    Falk Ochsendorf
    Department of Dermatology and Venereology, Clinic of the J W Goethe University, Frankfurt, Germany
    J Dtsch Dermatol Ges 4:828-41. 2006
    ..acnes and the severity of acne have been reported. Exact data on practical use of these compounds, such as differential efficacy or side effects are unavailable. A summary of currently available studies is presented...
  96. ncbi [Systemic antibiotic therapy of acne vulgaris]
    Falk Ochsendorf
    Zentrum Dermatologie und Venerologie, , Frankfurt
    J Dtsch Dermatol Ges 8:S31-46. 2010
    ..The data for the combination with topical treatments (topical benzoyl peroxide (BPO) or retinoids) suggest synergistic effects...
  97. ncbi Tretinoin gel microspheres 0.04% versus 0.1% in adolescents and adults with mild to moderate acne vulgaris: a 12-week, multicenter, randomized, double-blind, parallel-group, phase IV trial
    Richard Berger
    Hill Top Research, Inc, Milltown, New Jersey, USA
    Clin Ther 29:1086-97. 2007
    ..Tretinoin gel microsphere (TGM) formulations were developed to minimize these effects. A lower-strength TGM formulation may be desirable to further reduce exposure to tretinoin...
  98. ncbi Randomized tolerability analysis of clindamycin phosphate 1.2%-tretinoin 0.025% gel used with benzoyl peroxide wash 4% for acne vulgaris
    Zoe Diana Draelos
    Duke University School of Medicine, Durham, North Carolina, USA
    Cutis 86:310-8. 2010
    ..Use of a fixed combination of clindamycin phosphate 1.2% and tretinoin 0.025% in conjunction with a benzoyl peroxide (BPO) wash 4% targets several pathologic factors simultaneously and mitigates the potential for clindamycin-..
  99. ncbi 5-methylcytosine attack by free radicals arising from bromotrichloromethane in a model system: structures of reaction products
    G D Castro
    Centro de Investigaciones Toxicológicas CEITOX CITEFA CONICET, Buenos Aires, Argentina
    Free Radic Biol Med 17:419-28. 1994
    ..6) A partially silylated dihydroxythymine. When benzoyl peroxide was omitted from aerobic incubation mixtures, the compounds formed changed...
  100. ncbi Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesis
    B Patamalai
    University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957
    Mol Carcinog 9:220-9. 1994
    ..6 micrograms), benzoyl peroxide (20 mg), and cumene hydroperoxide (1...
  101. ncbi Adapalene 0.1%/benzoyl peroxide 2.5% gel: a review of its use in the treatment of acne vulgaris in patients aged ≥ 12 years
    Gillian M Keating
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Am J Clin Dermatol 12:407-20. 2011
    Adapalene 0.1%/benzoyl peroxide 2...

Research Grants5

  1. CRITICAL CHANGES AND FACTORS IN SKIN TUMOR PROGRESSION
    John DiGiovanni; Fiscal Year: 1992
    ..We propose to pursue the following specific aims: 1) Since benzoyl peroxide and ENU were found to be the most active agents in enhancing malignant progression, we will determine what ..
  2. MARKERS OF SKIN TUMOR PROGRESSION
    Andres Klein Szanto; Fiscal Year: 1992
    ..A series of experiments using benzoyl peroxide and hydrogen peroxide as third stage agents are proposed to further investigate this topic...
  3. Modulation of Bone's Mechanical Behavior by Bone Quality
    Stefan Judex; Fiscal Year: 2010
    ..Identification of these potential chemical targets will provide critical information for improved diagnostic, prophylactic, and therapeutic means of addressing bone quality defects in disease. ..
  4. Controlled Delivery System for Naltrexone
    EMMANUEL AKALA; Fiscal Year: 2004
    ....