tetracaine

Summary

Summary: A potent local anesthetic of the ester type used for surface and spinal anesthesia.

Top Publications

  1. ncbi Topical anesthetics in children: agents and techniques that equally comfort patients, parents, and clinicians
    B K Chen
    Pediatric and Adolescent Dermatology Children's Hospital, San Diego, and University of California, San Diego School of Medicine, San Diego, California, USA
    Curr Opin Pediatr 13:324-30. 2001
  2. ncbi The anesthetic effectiveness of lidocaine-adrenaline-tetracaine gel on finger lacerations
    Nicholas J White
    Department of Pediatrics, Division of Pediatric Emergency Medicine, Eastern Virginia Medical School, Children s Hospital of the King s Daughters, Norfolk, VA 23507, USA
    Pediatr Emerg Care 20:812-5. 2004
  3. ncbi Randomized, double-blind, placebo-controlled study evaluating the lidocaine/tetracaine patch for induction of local anesthesia prior to minor dermatologic procedures in geriatric patients
    Amy K Schecter
    Department of Dermatology, Brown Medical School, Providence, Rhode Island, USA
    Dermatol Surg 31:287-91. 2005
  4. ncbi Mechanical characterization and drug permeation properties of tetracaine-loaded bioadhesive films for percutaneous local anesthesia
    G P Moss
    School of Pharmacy and Biomedical Sciences, St Michael s Building, University of Portsmouth, White Swan Road, Portsmouth, PO1 2DT, UK
    Drug Dev Ind Pharm 32:163-74. 2006
  5. ncbi Tetracaine hydrochloride 0.5% versus lidocaine 2% jelly as a topical anesthetic agent in cataract surgery: comparative clinical trial
    Howard Amiel
    J Cataract Refract Surg 33:98-100. 2007
  6. pmc Effects of tetracaine on voltage-activated calcium sparks in frog intact skeletal muscle fibers
    Stephen Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Gen Physiol 127:291-307. 2006
  7. ncbi Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels
    Derek R Laver
    School of Biomedical Sciences and Pharmacy, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW 2308, Australia
    J Mol Cell Cardiol 51:357-69. 2011
  8. ncbi Toxicity of local anaesthetics
    B Cox
    Department of Anesthesiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Best Pract Res Clin Anaesthesiol 17:111-36. 2003
  9. ncbi Tetracaine topical anesthesia for myringotomy
    R A Hoffman
    Department of Otolaryngology/Head and Neck Surgery, Beth Israel Medical Center, New York, NY 10003, USA
    Laryngoscope 111:1636-8. 2001
  10. ncbi Selective effect of procaine, tetracaine and dibucaine on gold nanoparticles
    Aurora Mocanu
    Faculty of Chemistry and Chemical Engineering, Physical Chemistry Department, Babes Bolyai University of Cluj Napoca, 400028 Cluj Napoca, Romania
    J Nanosci Nanotechnol 12:8935-9. 2012

Research Grants

Detail Information

Publications193 found, 100 shown here

  1. ncbi Topical anesthetics in children: agents and techniques that equally comfort patients, parents, and clinicians
    B K Chen
    Pediatric and Adolescent Dermatology Children's Hospital, San Diego, and University of California, San Diego School of Medicine, San Diego, California, USA
    Curr Opin Pediatr 13:324-30. 2001
    ..Amethocaine, tetracaine, iontophoresis, and the S-caine patch, a product on the horizon for use in the pediatric population, also are ..
  2. ncbi The anesthetic effectiveness of lidocaine-adrenaline-tetracaine gel on finger lacerations
    Nicholas J White
    Department of Pediatrics, Division of Pediatric Emergency Medicine, Eastern Virginia Medical School, Children s Hospital of the King s Daughters, Norfolk, VA 23507, USA
    Pediatr Emerg Care 20:812-5. 2004
    To determine the effectiveness of lidocaine-adrenaline-tetracaine (LAT) in providing adequate anesthesia for the repair of finger lacerations and to monitor the risk of digital ischemia following application of LAT gel to finger ..
  3. ncbi Randomized, double-blind, placebo-controlled study evaluating the lidocaine/tetracaine patch for induction of local anesthesia prior to minor dermatologic procedures in geriatric patients
    Amy K Schecter
    Department of Dermatology, Brown Medical School, Providence, Rhode Island, USA
    Dermatol Surg 31:287-91. 2005
    ..Topical anesthetics offer a noninvasive method of anesthesia...
  4. ncbi Mechanical characterization and drug permeation properties of tetracaine-loaded bioadhesive films for percutaneous local anesthesia
    G P Moss
    School of Pharmacy and Biomedical Sciences, St Michael s Building, University of Portsmouth, White Swan Road, Portsmouth, PO1 2DT, UK
    Drug Dev Ind Pharm 32:163-74. 2006
    ..b>Tetracaine was found to plasticize films and while this effect was weak, it was significant both statistically and ..
  5. ncbi Tetracaine hydrochloride 0.5% versus lidocaine 2% jelly as a topical anesthetic agent in cataract surgery: comparative clinical trial
    Howard Amiel
    J Cataract Refract Surg 33:98-100. 2007
    To assess the anesthetic efficacy of tetracaine hydrochloride 0.5% (TetraVisc) versus lidocaine 2% jelly in routine cataract extraction.
  6. pmc Effects of tetracaine on voltage-activated calcium sparks in frog intact skeletal muscle fibers
    Stephen Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Gen Physiol 127:291-307. 2006
    ..greater than one channel per spark, sparks were measured in 8 mM [K(+)] Ringer's in the absence and presence of tetracaine, an inhibitor of RyR channel openings in bilayers...
  7. ncbi Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels
    Derek R Laver
    School of Biomedical Sciences and Pharmacy, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW 2308, Australia
    J Mol Cell Cardiol 51:357-69. 2011
    b>Tetracaine is a tertiary amine local anaesthetic which inhibits ryanodine receptors (RyRs), the calcium release channels of the sarcoplasmic reticulum (SR)...
  8. ncbi Toxicity of local anaesthetics
    B Cox
    Department of Anesthesiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Best Pract Res Clin Anaesthesiol 17:111-36. 2003
    ..2 to 0.01%. Peripheral nerve blocks are associated with the highest incidence of systemic toxicity (7.5 per 10,000) and the lowest incidence of serious neural injury (1.9 per 10,000)...
  9. ncbi Tetracaine topical anesthesia for myringotomy
    R A Hoffman
    Department of Otolaryngology/Head and Neck Surgery, Beth Israel Medical Center, New York, NY 10003, USA
    Laryngoscope 111:1636-8. 2001
    OBJECTIVES/HYPOTHESIS: To study the efficacy and safety of topical tetracaine anesthesia for office myringotomy and myringotomy with a tube...
  10. ncbi Selective effect of procaine, tetracaine and dibucaine on gold nanoparticles
    Aurora Mocanu
    Faculty of Chemistry and Chemical Engineering, Physical Chemistry Department, Babes Bolyai University of Cluj Napoca, 400028 Cluj Napoca, Romania
    J Nanosci Nanotechnol 12:8935-9. 2012
    ..by reduction of gold(III) chloride and its interaction with three local anesthetics (procaine, dibucaine or tetracaine) was investigated...
  11. ncbi Toxicities of topical ophthalmic anesthetics
    Hall T McGee
    Oregon Health and Science University, Casey Eye Institute, 3375 SW Terwilliger Blvd, Portland, OR 97239 4197, USA
    Expert Opin Drug Saf 6:637-40. 2007
    ..The most commonly used drugs today are proparacaine, tetracaine, benoxinate (oxybuprocaine) cocaine and lidocaine...
  12. ncbi A randomized controlled trial evaluating the efficacy of tetracaine gel for pain relief from peripherally inserted central catheters in infants
    Marilyn Ballantyne
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Adv Neonatal Care 3:297-307. 2003
    ..b>Tetracaine 4% gel (Ametop; Smith & Nephew Inc, St...
  13. pmc Effects of tetracaine on sarcoplasmic calcium release in mammalian skeletal muscle fibres
    L Csernoch
    Department of Physiology, University Medical School Debrecen, Hungary
    J Physiol 515:843-57. 1999
    ..coupling were studied under voltage clamp conditions in the presence and absence of the local anaesthetic tetracaine. 2...
  14. ncbi Cocaine versus tetracaine in septoplasty: a prospective, randomized, controlled trial
    E I Drivas
    Department of Otolaryngology, School of Medicine, University of Crete, Heraklion, Crete, Greece
    J Laryngol Otol 121:130-3. 2007
    ..The aim of this study was to evaluate the efficacy of cocaine 4 per cent solution, compared with tetracaine 2 per cent plus adrenaline, as a local anaesthetic for patients undergoing septoplasty.
  15. ncbi Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access
    J Sawyer
    Prism Ideas Ltd, Regent House Princes Court, Beam Heath Way, Nantwich, Chesire CW5 7PQ, UK
    Br J Anaesth 102:210-5. 2009
    We compared the lidocaine/tetracaine patch [Synera (USA), Rapydan (Europe)], a novel heat-aided patch using a eutectic mixture of lidocaine 70 mg and tetracaine 70 mg, with a eutectic mixture of lidocaine 25 mg ml(-1) and prilocaine 25 mg ..
  16. ncbi Involvement of the mitogen-activated protein kinase family in tetracaine-induced PC12 cell death
    Zhiming Tan
    Departments of Anesthesiology and Critical Care Medicine
    Anesthesiology 96:1191-201. 2002
    ....
  17. ncbi Lidocaine/tetracaine medicated plaster: in minor dermatological and needle puncture procedures
    Jamie D Croxtall
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 70:2113-20. 2010
    The lidocaine/tetracaine medicated plaster comprises a lidocaine/tetracaine 70 mg/70 mg patch and a controlled heat-assisted drug delivery pod that increases the diffusion of lidocaine and tetracaine into the dermis...
  18. ncbi Agonist-induced phasic and tonic responses in smooth muscle are mediated by InsP(3)
    John G McCarron
    Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, G12 8QQ, UK
    J Cell Sci 115:2207-18. 2002
    ..Thus depletion of the store by RyR activators abolished the InsP(3)-evoked Ca2+ transient. RyR inhibition (by tetracaine) reduced only STOCs but not the InsP(3) transient. InsP(3) contributes to both phasic and tonic contractions...
  19. pmc Sarcoplasmic reticulum calcium load regulates rat arterial smooth muscle calcium sparks and transient K(Ca) currents
    Serguei Y Cheranov
    Department of Physiology, University of Tennessee Health Science Center, Memphis 38163, USA
    J Physiol 544:71-84. 2002
    ..Ca(2+)-ATPase with an anti-phospholamban monoclonal antibody, or (ii) blocking Ca(2+) release from the SR with tetracaine, a membrane-permeant, reversible ryanodine-sensitive Ca(2+) release (RyR) channel blocker...
  20. pmc How effective is tetracaine 4% gel, before a venipuncture, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial
    Brigitte Lemyre
    Department of Pediatrics, University of Ottawa, Ottawa, Canada
    BMC Pediatr 7:7. 2007
    Procedural pain relief is sub-optimal in neonates. Topical tetracaine provides pain relief in children. Evidence of its efficacy and safety in neonates is limited...
  21. ncbi The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine
    S Sakura
    Department of Anesthesiology, Shimane Medical University, Izumo, Japan
    Anesthesiology 87:771-8. 1997
    ..Information regarding tetracaine has been limited to a single case report...
  22. ncbi A study on the influence of emulsion droplet size on the skin penetration of tetracaine
    P Izquierdo
    Departament de Tecnologia de Tensioactius, Institut d Investigacions Quimiques i Ambientals de Barcelona, CSIC, Barcelona, Spain
    Skin Pharmacol Physiol 20:263-70. 2007
    The influence of emulsion droplet size on the skin penetration of a model drug, tetracaine, was studied...
  23. ncbi [Topical anesthesia before vascular access in children. Comparison of a warmth-producing lidocaine-tetracaine patch with a lidocaine-prilocaine patch]
    S Soltesz
    Klinik für Anästhesie und Operative Intensivmedizin, Klinikum Leverkusen gGmbH, Am Gesundheitspark 11, 51375 Leverkusen, Deutschland
    Anaesthesist 59:519-23. 2010
    ..This study compared the effect of a new heated topical anesthesia delivery system containing lidocaine and tetracaine (Rapydan) with the lidocaine/prilocaine patch EMLA.
  24. ncbi Randomised controlled trial on the effectiveness of lidocaine gel vs tetracaine drops as the sole topical anaesthetic agent for primary pterygium surgery
    A L Young
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, New Territories, Hong Kong
    Eye (Lond) 23:1518-23. 2009
    ..To determine the effectiveness of lidocaine 2% gel vstetracaine 1% drops in primary pterygium surgery...
  25. ncbi Modification of smooth muscle Ca2+-sparks by tetracaine: evidence for sequential RyR activation
    Tim M Curtis
    Centre for Vision Science, School of Biomedical Science, Queen s University of Belfast, Institute of Clinical Science, Royal Victoria Hospital, Belfast, UK
    Cell Calcium 43:142-54. 2008
    Spontaneous Ca(2+)-sparks were imaged using confocal line scans of fluo-4 loaded myocytes in retinal arterioles. Tetracaine produced concentration-dependent decreases in spark frequency, and modified the spatiotemporal characteristics of ..
  26. pmc Calcium waves induced by hypertonic solutions in intact frog skeletal muscle fibres
    S Chawla
    Physiological Laboratory, Department of Anatomy, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 536:351-9. 2001
    ..3. The waves were blocked by the ryanodine receptor (RyR)-specific agents ryanodine and tetracaine, and potentiated by caffeine. 4...
  27. pmc Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes
    S Gyorke
    Department of Physiology, Texas Tech University Health Science Center, Lubbock 79430, USA
    J Physiol 500:297-309. 1997
    1. Confocal microfluorometry was used to study the effects of tetracaine on spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) in isolated rat ventricular myocytes. 2. At low concentrations (0.25-1...
  28. pmc Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization
    Jingzhong Zhang
    Pain Research Center, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Biophys J 92:3988-4001. 2007
    Interactions of the local anesthetic tetracaine with unilamellar vesicles made of dimyristoyl or dipalmitoyl phosphatidylcholine (DMPC or DPPC), the latter without or with cholesterol, were examined by following changes in the drug's ..
  29. ncbi High-concentration tetracaine for the management of trigeminal neuralgia: quantitative assessment of sensory function after peripheral nerve block
    I A Radwan
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi shi, Japan
    Clin J Pain 17:323-6. 2001
    This study examined the effects of peripheral nerve block with high-concentration tetracaine for the management of trigeminal neuralgia, and evaluated sensory function by measuring the postblock current perception threshold.
  30. ncbi A randomized, double-blind, placebo-controlled study of the efficacy of tetracaine gel (Ametop) for pain relief during topical photodynamic therapy
    M V Holmes
    Photobiology Unit, University Department of Dermatology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Br J Dermatol 150:337-40. 2004
    ..Many patients find topical 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) painful. Local anaesthetics are not routinely used and their effect on PDT pain has not been examined...
  31. pmc Dynamic regulation of sarcoplasmic reticulum Ca(2+) content and release by luminal Ca(2+)-sensitive leak in rat ventricular myocytes
    V Lukyanenko
    Department of Physiology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biophys J 81:785-98. 2001
    ..The ryanodine receptor (RyR) blockers tetracaine and Mg(2+) transiently suppressed the frequency of sparks...
  32. ncbi LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast
    Tomoyuki Araki
    Department of Biological Science, Graduate School of Science, University of Tokyo, Hongo, Japan
    Genes Genet Syst 80:325-43. 2005
    ..the pathway of local anesthetics' action, we isolated and characterized mutants that were hyper-sensitive to tetracaine, and at the same time, temperature-sensitive for growth...
  33. ncbi Self-warming lidocaine/tetracaine patch effectively and safely induces local anesthesia during minor dermatologic procedures
    Brian Berman
    Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
    Dermatol Surg 31:135-8. 2005
    Dermatologic procedures often cause some degree of pain. A self-warming patch containing lidocaine and tetracaine (L/T) was developed to provide topical local anesthesia prior to painful procedures.
  34. ncbi The lidocaine/tetracaine peel: a novel topical anesthetic for dermatologic procedures in adult patients
    Tina S Alster
    Washington Institute of Dermatologic Laser Surgery, Washington, DC 20037, USA
    Dermatol Surg 33:1073-81. 2007
    The 7% lidocaine and 7% tetracaine (LT) peel is a self-occlusive, topical local anesthetic that has been proven safe and effective for use in conjunction with many dermatologic procedures, including cryotherapy, collagen injections, and ..
  35. pmc IP3-mediated Ca2+ increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP3-mediated Ca2+ increases in guinea-pig colonic smooth muscle cells
    Debbi MacMillan
    Institute of Biomedical and Life Sciences, Neuroscience and Biomedical Systems, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    J Physiol 569:533-44. 2005
    ..Evidence for this proposal has relied largely on the use of blocking drugs such as ryanodine, tetracaine and dantrolene, reportedly specific inhibitors of RyRs...
  36. ncbi A comparison of the neurotoxic effects on the spinal cord of tetracaine, lidocaine, bupivacaine, and ropivacaine administered intrathecally in rabbits
    Atsuo Yamashita
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Anesth Analg 97:512-9, table of contents. 2003
    ..of the cerebrospinal fluid (CSF) may be clue phenomena to elucidate mechanisms of neurotoxicity of intrathecal tetracaine. However, little is known about whether this is true for other local anesthetics...
  37. ncbi Warm lidocaine/tetracaine patch versus placebo before pediatric intravenous cannulation: a randomized controlled trial
    Adam J Singer
    Department of Emergency Medicine, Stony Brook University, Stony Brook, NY 11794 8350, USA
    Ann Emerg Med 52:41-7. 2008
    ..intravenous (IV) cannulation in pediatric emergency department (ED) patients after applying a topical lidocaine/tetracaine patch versus placebo...
  38. ncbi [Tetracaine drops versus lidocaine gel for topical anaesthesia in cataract surgery]
    Stephan Irle
    Augenklinik I, Evangelisches und Johanniter Klinikum Duisburg gGmbH, Duisburg
    Klin Monbl Augenheilkd 220:625-8. 2003
    in addition to intracameral anaesthesia, drop anaesthesia with tetracaine drops has been established for topical anaesthesia in cataract surgery. Anaesthesia with lidocaine gel is less established...
  39. ncbi Effects of tetracaine and bupivacaine on chemiluminescence generated by formyl-methionyl-leucyl-phenylalanine-stimulated human leukocytes and cell-free systems
    Berrin Gunaydin
    Department of Pharmacology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    Int Immunopharmacol 3:757-64. 2003
    We investigated the abilities of an ester-type local anesthetic tetracaine and an amide-type local anesthetic bupivacaine to inhibit reactive oxygen and/or nitrogen species generated by either human leukocytes or cell-free systems via ..
  40. ncbi Interaction of bupivacaine and tetracaine with the sarcoplasmic reticulum Ca2+ release channel of skeletal and cardiac muscles
    H Komai
    Department of Anesthesiology, University of Wisconsin, Madison 53792 3272, USA
    Anesthesiology 90:835-43. 1999
    ..Furthermore, it is not known whether the toxicity depends on the unique chemical characteristics of bupivacaine and whether the toxicity is found only in skeletal muscle...
  41. ncbi The long lasting effects of peripheral nerve blocks for trigeminal neuralgia using high concentration of tetracaine dissolved in bupivacaine
    F Goto
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi shi, Japan
    Pain 79:101-3. 1999
    ..5% bupivacaine or 1% mepivacaine dissipated within a few days, however, the effects of nerve blocks using 4% tetracaine dissolved in 0.5% bupivacaine continued for more than 3 months...
  42. pmc How effective is tetracaine 4% gel, before a peripherally inserted central catheter, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial [ISRCTN75884221]
    Brigitte Lemyre
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    BMC Med 4:11. 2006
    Procedural pain relief is sub-optimal in infants, especially small and vulnerable ones. Tetracaine gel 4% (Ametop, Smith-Nephew) provides pain relief in children and larger infants, but its efficacy in smaller infants and for peripherally ..
  43. ncbi No more tears: a randomized controlled double-blind trial of Amethocaine gel vs. placebo in the management of procedural pain in neonates
    J Moore
    Neonatal Unit, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QH, UK
    J Adv Nurs 34:475-82. 2001
    ..During a comparative double-blind study, the efficacy of Amethocaine local anaesthetic gel was compared with that of a placebo gel to establish their effect on the reduction of behavioural and physiological responses to pain in neonates...
  44. pmc Clinical experiences with a novel percutaneous amethocaine preparation: prevention of pain due to venepuncture in children
    A D Woolfson
    School of Pharmacy, Queen s University of Belfast
    Br J Clin Pharmacol 30:273-9. 1990
    ..There was no evidence of sensitisation on subsequent exposure to the preparation. 6. The short application time required was found to be advantageous to ward and clinic routines...
  45. pmc Topical amethocaine gel in the newborn infant: how soon does it work and how long does it last?
    A Jain
    Department of Neonatal Medicine, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Arch Dis Child Fetal Neonatal Ed 83:F211-4. 2000
    ..To explore the time of onset and duration of action of topical amethocaine gel in the newborn infant...
  46. ncbi Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placement
    Anna Taddio
    Department of Pharmacy, The Hospital for Sick Children, Faculty of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario
    JAMA 295:793-800. 2006
    ..There is limited evidence of the analgesic effectiveness of opioid analgesia or topical anesthesia during central line placement in neonates, and there are no previous studies of their relative effectiveness...
  47. pmc Does topical amethocaine gel reduce the pain of venepuncture in newborn infants? A randomised double blind controlled trial
    A Jain
    Department of Neonatal Medicine, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Arch Dis Child Fetal Neonatal Ed 83:F207-10. 2000
    ..Topical amethocaine provides effective pain relief during venepuncture in children, and has been shown to have a local anaesthetic action in the newborn...
  48. pmc A comparison of the effects of ATP and tetracaine on spontaneous Ca(2+) release from rat permeabilised cardiac myocytes
    G L Smith
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    J Physiol 534:37-47. 2001
    ..5 mM ATP were similar to those observed during perfusion with 50 microM tetracaine. In 0...
  49. ncbi Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: in vivo
    Mohammad Changez
    Centre for Biomedical Engineering, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi 110016, India
    Colloids Surf B Biointerfaces 48:58-66. 2006
    In vivo transdermal permeation of tetracaine hydrochloride encapsulated in lecithin water-in-oil and oil-in-water microemulsion was studied...
  50. ncbi A multiply charged tetracaine derivative blocks cyclic nucleotide-gated channels at subnanomolar concentrations
    Ambarish S Ghatpande
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biochemistry 42:265-70. 2003
    ..CNG channels are members of the superfamily of voltage-gated ion channels, and the local anesthetic tetracaine is known to block CNG channels in a manner that resembles the block of voltage-gated Na(+) channels...
  51. pmc Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies
    Timothy Strassmaier
    Department of Physiology and Pharmacology and Neurological Sciences Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Med Chem 48:5805-12. 2005
    Five new tetracaine analogues were synthesized and evaluated for potency of blockade of cyclic nucleotide-gated channels relative to a multiply charged tetracaine analogue described previously...
  52. pmc Topical amethocaine gel for pain relief of heel prick blood sampling: a randomised double blind controlled trial
    A Jain
    Department of Neonatal Medicine, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Arch Dis Child Fetal Neonatal Ed 84:F56-9. 2001
    ..Use of a topical local anaesthetic does not relieve this pain. A 4% w/w amethocaine gel (Ametop) reduces the pain of venepuncture in the newborn but has not been tried with heel pricks...
  53. pmc Charged tetracaine as an inactivation enhancer in batrachotoxin-modified Na+ channels
    G K Wang
    Department of Anesthesia Research Laboratories, Harvard Medical School, Boston, Massachusetts
    Biophys J 67:1851-60. 1994
    ..Herein, we describe our studies of a third type of LA, represented by tetracaine as a dual blocker that binds strongly with closed channels but also binds to a lesser extent with open channels ..
  54. ncbi Liquid-phase microextraction combined with high-performance liquid chromatography for the determination of local anaesthetics in human urine
    Ming Ma
    State Key Laboratory of Chemo Biosensing and Chemometrics, Hunan University, Changsha 410082, PR China
    J Pharm Biomed Anal 40:128-35. 2006
    ..HPLC) is presented for the simultaneous analysis of local anaesthetics, lidocaine, bupivacaine, and tetracaine, from human urine sample...
  55. ncbi [Comparison between the pain induced by phacoemulsification with topical anesthesia and by peribulbar anesthesia without sedation]
    Roberto Pinto Coelho
    Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeca e Pescoco, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo
    Arq Bras Oftalmol 68:45-8. 2005
    ..To compare pain sensation induced by phacoemulsification with topical anesthesia with that by peribulbar anesthesia, without sedation...
  56. ncbi Pain induced by phacoemulsification without sedation using topical or peribulbar anesthesia
    David T L Liu
    J Cataract Refract Surg 32:2; author reply 2. 2006
  57. ncbi Topical anesthetics for dermal instrumentation: a systematic review of randomized, controlled trials
    Anthony Eidelman
    Department of Anesthesiology and Pain Medicine, Caritas St Elizabeth s Medical Center, Tufts School of Medicine, Boston, MA, USA
    Ann Emerg Med 46:343-51. 2005
    ....
  58. pmc Randomised controlled trial of sub-Tenon's block versus topical anaesthesia for cataract surgery: a comparison of patient satisfaction
    H Ruschen
    Moorfields Eye Hospital, St Ann s Diagnostic and Treatment Centre, London EC1V 2PD, UK
    Br J Ophthalmol 89:291-3. 2005
    ..The authors decided to investigate the issue of patient satisfaction using the recently developed Iowa Satisfaction with Anesthesia Scale (ISAS)...
  59. ncbi Local anesthetics induce human renal cell apoptosis
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Nephrol 23:129-39. 2003
    ..We examined the effects of chronic (48 h) local anesthetic treatment (lidocaine, bupivacaine and tetracaine) on human proximal tubular (HK-2) cells...
  60. ncbi Comparison of lidocaine 2% gel versus amethocaine as the sole anesthetic agent for strabismus surgery
    Christopher B O Yu
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Hong Kong, People s Republic of China
    Ophthalmology 110:1426-9. 2003
    ..To compare the efficacy of lidocaine 2% gel with amethocaine 1% eyedrops as the sole anesthetic agent for one-stage adjustable suture strabismus surgery...
  61. ncbi Effects of local anesthetics on human bladder contractility
    Seung June Oh
    Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    Neurourol Urodyn 24:288-94. 2005
    ..We investigated the invitro effects of local anesthetics on the contractility of the human bladder...
  62. ncbi Thirty-minute application of the S-Caine peel prior to nonablative laser treatment
    Seema N Doshi
    Department of Dermatology, University of Texas Houston Medical School, USA
    Dermatol Surg 29:1008-11. 2003
    ..Although topical anesthetics have proven efficacious, they possess inherent limitations related to ease of use...
  63. ncbi Two randomized, double-blind, placebo-controlled studies evaluating the S-Caine Peel for induction of local anesthesia before long-pulsed Nd:YAG laser therapy for leg veins
    John Z S Chen
    Laser and Skin Surgery Center of New York, New York 10016, USA
    Dermatol Surg 29:1012-8. 2003
    ..Topical anesthetics are valuable tools for many dermatologic procedures...
  64. ncbi Pupil dilatation with intracameral 1% lidocaine during glaucoma filtering surgery
    Punita Kumari Sodhi
    ew Delhi, India
    Am J Ophthalmol 137:783-4; author reply 784-5. 2004
  65. ncbi The use of EMLA cream to decrease venipuncture pain in children
    Tanya L Rogers
    School of Nursing, West Virginia University, Morgantown, WV, USA
    J Pediatr Nurs 19:33-9. 2004
    ..EMLA cream was compared with placebo, iontophoresis, and amethocaine cream and was found to be an effective local anesthetic for pediatric venipuncture pain during both intravenous cannulation and phlebotomy...
  66. ncbi Efficacy of intraoral topical anesthetics in children
    Ekaterini Paschos
    Department of Orthodontics, Dental School, LMU University Munich, Goethestr 70, 80336 Munchen, Germany
    J Dent 34:398-404. 2006
    ..Only a few studies have been performed in children. Some non-placebo controlled studies have been carried out to compare the efficacy in reducing children's injection pain between different topical anesthetics..
  67. ncbi Topical anesthetic sprays directly associated with a serious, sometimes fatal adverse drug reaction: methemoglobinemia
    Susan Paparella
    Consulting Services, Institute for Safe Medication Practices, Huntingdon Valley, PA, USA
    J Emerg Nurs 31:468-9. 2005
  68. ncbi 60-minute application of S-Caine Peel prior to 1,064 nm long-pulsed Nd:YAG laser treatment of leg veins
    Ming H Jih
    DermSurgery Associates, Houston, Texas 77030, USA
    Lasers Surg Med 34:446-50. 2004
    ..To evaluate the efficacy of the S-Caine Peel for providing topical anesthesia after a 60-minute application...
  69. ncbi Anesthetic implications of Leigh's syndrome
    Torin Shear
    University of Missouri School of Medicine, Columbia, MO 65212, USA
    Paediatr Anaesth 14:792-7. 2004
    ..The authors present the use of spinal anesthesia for muscle biopsy in a 19 month old with LS and review the potential anesthetic implications of this syndrome...
  70. ncbi Local anesthetics worsen renal function after ischemia-reperfusion injury in rats
    H Thomas Lee
    Department of Anesthesiology, Anesthesiology Research Laboratories, Columbia University, P and S Box 46 PH 5, 630 W 168th Street, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 286:F111-9. 2004
    ..kg-1.h-1), bupivacaine (0.4 mg.kg-1.h-1), tetracaine (1 mg.kg-1...
  71. ncbi Randomized trial of novel tetracaine patch to provide local anaesthesia in neonates undergoing venepuncture
    C P Long
    School of Pharmacy, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    Br J Anaesth 91:514-8. 2003
    ..We assessed a novel tetracaine-based self-adhesive patch in providing controlled local anaesthesia before venepuncture.
  72. ncbi Intravenous ketamine sedation for painful oncology procedures
    Dan Evans
    Department of Anesthesiology, British Columbia Children s Hospital, University of British Columbia, Vanouver, BC, Canada
    Paediatr Anaesth 15:131-8. 2005
    ..The aim of the study was to determine the efficacy and adverse effects of intravenous (i.v.) ketamine sedation administered by nonanesthetist physicians for painful procedures...
  73. ncbi Topical tetracaine prior to arterial puncture: a randomized, placebo-controlled clinical trial
    Shawn D Aaron
    Division of Respiratory Medicine, Department of Medicine, The Ottawa Hospital, The Ottawa Hospital Research Institute, General Campus, Room 1812F, 501 Smyth Road, Ottawa, Ont, Canada K1H 8L6
    Respir Med 97:1195-9. 2003
    ..randomized, double-blind, placebo-controlled clinical trial was to determine whether a topical anesthetic agent (tetracaine) provides effective local analgesia prior to radial arterial puncture...
  74. ncbi [Suture of skin lacerations using LAT gel (lidocaine, adrenaline, tetracaine)]
    E Chipont Benabent
    , , , Alicante
    Arch Soc Esp Oftalmol 76:505-8. 2001
    ..Concentrations in final gel solution were as follows: Tetracaine 1.0%. Lidocaine 1.5% and Adrenaline 0.1%...
  75. ncbi Topical anaesthesia and intravenous cannulation success in paediatric patients: a randomized double-blind trial
    G Arendts
    Department of Emergency Medicine, St George Hospital, Kogarah NSW 2217, Australia
    Br J Anaesth 100:521-4. 2008
    ..v. cannulation in the paediatric population. The null hypothesis of this study was that no difference exists in the initial success rate of cannulation between two commonly used topical anaesthetics...
  76. pmc Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells
    M Lahav
    Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Clin Exp Immunol 127:226-33. 2002
    ....
  77. ncbi Safety of cataract surgery under topical anesthesia with oral sedation without anesthetic monitoring
    Guillermo Rocha
    Brandon Regional Health Centre, University of Manitoba, Brandon, Man
    Can J Ophthalmol 42:288-94. 2007
    ..The current study was conducted to determine whether topical anesthesia with oral sedation and without an anesthetist present in the operating room is a safe and cost-effective strategy for low-risk patients undergoing cataract surgery...
  78. ncbi Effects of local anesthetics on the contractility of rat bladders
    S J Oh
    Department of Urology, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    J Urol 165:2044-50. 2001
    ..We investigated the effects of tetracaine, bupivacaine and lidocaine on baseline spontaneous contractions and contractions induced by various stimuli, ..
  79. ncbi A randomised, double-blind, placebo-controlled, comparative study of topical skin analgesics and the anxiety and discomfort associated with venous cannulation
    A F Speirs
    Division of Restorative Dentistry, Leeds Dental Institute, University of Leeds, UK
    Br Dent J 190:444-9. 2001
    ..This has application in the management of anxious patients undergoing intravenous sedation, suggesting that topical analgesia prior to venous cannulation may significantly aid anxiolysis...
  80. ncbi Pain management for neonatal circumcision
    A Taddio
    Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Drugs 3:101-11. 2001
    ....
  81. ncbi Corneal sensation after topical anesthesia
    K Nomura
    Department of Ophthalmology, University of Rochester School of Medicine, New York, USA
    Cornea 20:191-3. 2001
    PURPOSE: To compare the topical effects of tetracaine, lidocaine, and bupivacaine on corneal sensitivity in normal eyes. METHODS: Corneal touch sensitivity was measured with a Cochet-Bonnet anesthesiometer before and at 2...
  82. ncbi Topical anesthesia for phacoemulsification and painless subconjunctival antibiotic injection
    V V Kayarkar
    Department of Ophthalmology, Doncaster Royal Infirmary, United Kingdom
    J Cataract Refract Surg 27:198-200. 2001
    ..Eighty-seven percent of patients found the injection painless, 6.5% reported that the pain was very negligible, and 6.5% reported a moderate degree of pain...
  83. ncbi Brief report: a randomized controlled trial of Synera versus lidocaine for epidural needle insertion in labouring parturients
    Ronald B George
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    Can J Anaesth 55:168-71. 2008
    ..an oxygen-activated heating component to enhance the delivery of a eutectic mixture of lidocaine (70 mg) and tetracaine (70 mg), has provided analgesia for minor, dermatological procedures...
  84. ncbi Routine immunization practices: use of topical anesthetics and oral analgesics
    Anna Taddio
    Department of Pharmacy, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Pediatrics 120:e637-43. 2007
    ..Our objective was to evaluate analgesic use during childhood immunization...
  85. ncbi Systemic exposure to lidocaine and tetracaine is low after an application of a lidocaine 7%-tetracaine 7% peel in adults
    Lazarre Ogden
    Department of Anesthesiology, University of Utah Health Science Center, Salt Lake City, Utah, USA
    Int J Dermatol 47:87-90. 2008
    The lidocaine 7%-tetracaine 7% (LT) peel has been demonstrated to be useful for a variety of dermatologic applications, including cosmetic, laser, and vascular access procedures...
  86. ncbi Does amethocaine gel influence blood results obtained from capillary sampling?
    Noelle Llewellyn
    Acute Pain Service, Birmingham Children s Hospital NHS Trust
    Paediatr Nurs 18:29-31. 2006
    ..Topical anaesthesia might alleviate the pain associated with capillary blood sampling but would it affect the blood sample?..
  87. ncbi Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in children
    Anna Taddio
    Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Pharmacother 36:687-92. 2002
    To determine the relative efficacy of lidocaine-prilocaine and tetracaine for procedural pain in children.
  88. ncbi Patch-test reactions to topical anesthetics: retrospective analysis of cross-sectional data, 2001 to 2004
    Erin M Warshaw
    Dermatitis 19:81-5. 2008
    ..Allergy to topical anesthetics is not uncommon. The cross-reactivity among topical anesthetics and the screening value of benzocaine alone are not well understood...
  89. ncbi Effective topical anesthetic agents and techniques
    John G Meechan
    Department of Oral and Maxillofacial Surgery, Dental School, Framlington Place, Newcastle upon Tyne, NE2 4BW, United Kingdom
    Dent Clin North Am 46:759-66. 2002
    ..There is no evidence that topical anesthetics have any value in reducing the discomfort of deep regional block administrations such as inferior alveolar nerve block injections...
  90. ncbi Combined spinal and epidural anesthesia for abdominal aortic aneurysm surgery in patients with severe chronic pulmonary obstructive disease
    J A Flores
    Department of Cardiovascular Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Int Angiol 21:218-21. 2002
    ..The purpose of this paper is to report our experience in the use of combined spinal and epidural anesthesia (CSEA) for open AAA repair in such patients...
  91. ncbi A randomized controlled trial of the effectiveness of topical amethocaine in reducing pain during arterial puncture
    Ngoc Q Tran
    Department of Respiratory Medicine, Bowen Centre, Austin Campus, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
    Chest 122:1357-60. 2002
    ..To determine if topical 4% amethocaine gel can reduce the pain associated with arterial punctures...
  92. doi Cataract surgery complication rates
    Luciano P Bellini
    Ophthalmology 115:1432; author reply 1432-3. 2008
  93. ncbi Principles of office anesthesia: part II. Topical anesthesia
    Suriti Kundu
    Scripps Clinic, San Diego, California, USA
    Am Fam Physician 66:99-102. 2002
    ..The combination of tetracaine, adrenaline (epinephrine), and cocaine, better known as TAC, was the first topical agent available for analgesia ..
  94. ncbi EMLA and amethocaine for reduction of children's pain associated with needle insertion
    J A Lander
    University of Alberta, Nursing, 5 120A Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3
    Cochrane Database Syst Rev 3:CD004236. 2006
    ..Children often experience pain from needle insertion procedures; therefore, several topical anaesthetics have been developed...
  95. ncbi Radial artery cannulation: topical amethocaine gel versus lidocaine infiltration
    S J Olday
    Department of Anaesthesia, Royal Infirmary of Edinburgh, UK
    Br J Anaesth 88:580-2. 2002
    ..A previous study had shown topical analgesia with EMLA cream reduced pain, shortened cannulation time, and improved success rates when compared with lidocaine infiltration...
  96. ncbi Amphiphilic effects of local anesthetics on rotational mobility in neuronal and model membranes
    Il Yun
    Department of Dental Pharmacology and Biophysics, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, South Korea
    Biochim Biophys Acta 1564:123-32. 2002
    ..mechanism of pharmacological action of local anesthetics, we carried out a study of the membrane actions of tetracaine, bupivacaine, lidocaine, prilocaine and procaine...
  97. ncbi Benefit and risks of local anesthetics in infants and children
    Joel B Gunter
    Department of Anesthesia, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Paediatr Drugs 4:649-72. 2002
    ..The use of tetracaine has generally been limited to spinal and topical anesthesia...
  98. ncbi From cocaine to ropivacaine: the history of local anesthetic drugs
    Y A Ruetsch
    University of Zurich, Department of Anesthesiology, Orthopedic University Clinic Balgrist, Switzerland
    Curr Top Med Chem 1:175-82. 2001
    ..were synthesized between 1891 and 1930, such as tropocaine, eucaine, holocaine, orthoform, benzocaine, and tetracaine. In addition, amino amide local anesthetics were prepared between 1898 and 1972 including nirvaquine, procaine, ..
  99. ncbi Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics
    Toshiharu Kasaba
    Department of Anesthesiology, Miyazaki Medical College, Kiyotake cho, Japan
    Anesth Analg 97:85-90, table of contents. 2003
    ..We compared the neurotoxicity of procaine, mepivacaine, ropivacaine, bupivacaine, lidocaine, tetracaine, and dibucaine by using cultured neurons from the freshwater snail Lymnaea stagnalis...
  100. ncbi Immunological modulation by lidocaine-epinephrine and prilocaine-felypressin on the functions related to natural immunity in neutrophils and macrophages
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Osaka 573 1121, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 4:29-36. 2004
    ..possible abilities of both local anesthetic alone including lidocaine, mepivacaine, procaine, prilocaine and tetracaine, and local anesthetics with blood vessel contraction drugs including lidocaine with epinephrine and prilocaine ..
  101. ncbi Gateways to clinical trials
    M Bayes
    Prous Science, Barcelona, Spain
    Methods Find Exp Clin Pharmacol 27:411-61. 2005
    ..Lacosamide, landiolol, lanthanum carbonate, lasofoxifene tartrate, LB-80380, lenalidomide, lidocaine/tetracaine, linezolid, liposomal doxorubicin, liposomal vincristine sulfate, lopinavir, lopinavir/ritonavir, lumiracoxib, ..

Research Grants22

  1. THERAPEUTIC NA+ CHANNEL BLOCKERS: RECEPTOR & DRUG DESIGN
    GING WANG; Fiscal Year: 2007
    ..Such drugs, either taken orally or injected locally, may be beneficial for patients with chronic and intractable cancer pain. ..
  2. CALCIUM ION INTERACTIONS IN DEVELOPING DENTAL TISSUES
    DALE EISENMANN; Fiscal Year: 1990
    ..The following experimental agents will be utilized: calcium antagonists cobalt, verapamil, lanthanum and tetracaine; Ca+2-Mg+2 ATPase inhibitors quercetin and ethacrynic acid; the hormone calcitonin; the anti-microtubular agent ..
  3. NEW DERMAL ANESTHETICS
    VINCENT CIOFALO; Fiscal Year: 1999
    ..After preliminary studies, we have determined that ester-type local anesthetics (ex. tetracaine, oxybutynin) cause too much tissue irritation to be useful as dermal anesthetics and amide-type local ..
  4. ALTERED CA2+ HOMEOSTASIS AND SIGNAL TRANSDUCTION IN SEPS
    JUDY SPITZER; Fiscal Year: 1991
    ..Implicating such mechanisms in some functional impairments, we may provide a rational basis for novel therapeutic modalities using agents inhibiting protein kinase C (e.g. chlorpromazine, tetracaine and polyamines).
  5. FUNCTION AND REGULATION OF ION CHANNELS IN RETINAL RODS
    Jeffrey W Karpen; Fiscal Year: 2010
    ..Derivatives of tetracaine will be optimized for pore block and then linked to cGMP with polymer chains to greatly enhance the specificity ..
  6. ROLE OF ION FLUXES IN THE HYPOGLYCEMIC RESPONSE
    NAOMI KRAUS; Fiscal Year: 1980
    ..The effects of tetracaine, Na-free and high K perfusate agents and experimental conditions in which glucagon-induced ion fluxes and ..
  7. MOLECULAR BASIS OF LIGAND/SODIUM CHANNEL INTERACTIONS
    GING WANG; Fiscal Year: 2002
    ....
  8. FUNCTIONAL ARCHITECTURE OF RETINAL ROD CNG ION CHANNELS
    SHARONA GORDON; Fiscal Year: 2006
    ..Through these experiments we expect to gain significant insight into how the cGMP-gated ion channels function during visual transduction. ..
  9. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
    ..To study the specific aims of the project the effects of RTX will be examined in rats by behavioral methods; and whole cell voltage-clamp technique will be used to identify a mechanism for impulse failure induced by RTX. ..
  10. Injury-Evoked Regeneration Mechanism in Olfactory System
    Colleen Hegg; Fiscal Year: 2008
    ..Agents that modify the effects of purinergics and purinergic receptors are readily available and could therapeutically modulate cell proliferation and differentiation, in the olfactory system and in the CNS. ..
  11. Aging, Serotonin and Reversal Learning
    MICHAEL RAGOZZINO; Fiscal Year: 2008
    ..These studies have the potential of developing a novel treatment for the learning and memory deficits observed in aging and Alzheimer's disease. [unreadable] [unreadable] [unreadable]..
  12. The role of I-kappaB in control of glial inflammation
    Douglas Feinstein; Fiscal Year: 2006
    ..These experiments will provide targets for therapeutic intervention to reduce pathological NOS2 in brain, and help develop a new animal model for examining brain inflammatory in the context of diminished NE levels. ..
  13. Striatal Acetylcholine and Behavioral Flexibility
    MICHAEL RAGOZZINO; Fiscal Year: 2005
    ....
  14. EXCITATION-CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 2005
    ..Overall, the knowledge obtained will contribute importantly to understanding the mechanisms of intracellular Ca signaling and the mechanisms by which specific drugs and diseases affect muscle performance. ..
  15. SALIVARY SECRETION-ROLE OF CALCIUM
    EILEEN WATSON; Fiscal Year: 2005
    ..Mechanisms/pathways involved in AA/metabolite-mediated cAMP signaling will be assessed by correlating MAPK activation with cAMP synthesis and degradation. ..
  16. Purinergic Receptors in Olfactory System
    Colleen Hegg; Fiscal Year: 2003
    ..Because ATP is released during neurotransmission and by noxious stimuli, these studies may elucidate mechanisms for the observed reduction in olfactory sensitivity during exposure to noxious agents. ..
  17. MYELIN PO GLYCOPROTEIN: STRUCTURE & ADHESIVE MECHANISMS
    Daniel Kirschner; Fiscal Year: 2003
    ....
  18. G PROTEINS AND PAROTID SECRETORY GRANULE
    EILEEN WATSON; Fiscal Year: 2002
    ..These studies will also provide a framework for examining cellular biochemical defects in diseases relating to salivary dysfunction. ..
  19. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ....
  20. MECHANISMS OF SKELETAL MUSCLE FATIGUE
    Jay Williams; Fiscal Year: 2001
    ..In addition, it will attempt to identify direct links between muscle glycogen levels, CHO metabolism and the fatigue process. ..
  21. Treatment of Demyelinating Disease with HSP90 Inhibitors
    Douglas L Feinstein; Fiscal Year: 2010
    ....