citrates

Summary

Top Publications

  1. ncbi Regional citrate versus systemic heparin for anticoagulation in critically ill patients on continuous venovenous haemofiltration: a prospective randomized multicentre trial
    Gerd R Hetzel
    Department of Nephrology, Medical Faculty, Heinrich Heine University Dusseldorf, Germany
    Nephrol Dial Transplant 26:232-9. 2011
  2. ncbi Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity
    Jürgen G Okun
    Department of Pediatrics, Division of Metabolic and Endocrine Diseases, Im Neuenheimer Feld 150, Federal Republic of Germany
    J Biol Chem 277:14674-80. 2002
  3. ncbi Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
    J Neurosci 23:1026-40. 2003
  4. ncbi Continuous venovenous hemofiltration with or without predilution regional citrate anticoagulation: a prospective study
    S Azam Nurmohamed
    Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands
    Blood Purif 25:316-23. 2007
  5. ncbi Studies of propionate toxicity in Salmonella enterica identify 2-methylcitrate as a potent inhibitor of cell growth
    A R Horswill
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706 1567, USA
    J Biol Chem 276:19094-101. 2001
  6. ncbi Continuous venovenous hemofiltration with citrate-based replacement fluid: efficacy, safety, and impact on nutrition
    Azra Bihorac
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Kidney Dis 46:908-18. 2005
  7. ncbi Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain
    Stefan Kölker
    Department of General Pediatrics, Division of Metabolic and Endocrine Diseases, University Children s Hospital Heidelberg, D 69120 Heidelberg, Germany
    J Biol Chem 278:47388-93. 2003
  8. pmc In Salmonella enterica, 2-methylcitrate blocks gluconeogenesis
    Christopher J Rocco
    Department of Bacteriology, University of Wisconsin, 1550 Linden Dr, Madison, WI 53706 1521, USA
    J Bacteriol 192:771-8. 2010
  9. pmc Characterization of pyoverdine and achromobactin in Pseudomonas syringae pv. phaseolicola 1448a
    Jeremy G Owen
    School of Biological Sciences, Victoria University of Wellington, Kelburn Parade, PO Box 600, Wellington 6140, New Zealand
    BMC Microbiol 11:218. 2011
  10. ncbi Urinary citrate and renal stone disease: the preventive role of alkali citrate treatment
    Renata Caudarella
    Centro Studi del Metabolismo Minerale, Fondazione Villa Maria, Lugo, Ravenna, Italy
    Arch Ital Urol Androl 81:182-7. 2009

Research Grants

Detail Information

Publications223 found, 100 shown here

  1. ncbi Regional citrate versus systemic heparin for anticoagulation in critically ill patients on continuous venovenous haemofiltration: a prospective randomized multicentre trial
    Gerd R Hetzel
    Department of Nephrology, Medical Faculty, Heinrich Heine University Dusseldorf, Germany
    Nephrol Dial Transplant 26:232-9. 2011
    ..However, data from randomized trials comparing citrate anticoagulation with systemic heparinization are very limited...
  2. ncbi Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity
    Jürgen G Okun
    Department of Pediatrics, Division of Metabolic and Endocrine Diseases, Im Neuenheimer Feld 150, Federal Republic of Germany
    J Biol Chem 277:14674-80. 2002
    ..We propose that neuropathogenesis of methylmalonic aciduria may involve an inhibition of complex II and the tricarboxylic acid cycle by accumulating toxic organic acids, and synergistic secondary excitotoxic mechanisms...
  3. ncbi Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
    J Neurosci 23:1026-40. 2003
    ..These results provide the first evidence that ipsilateral and mirror-image inflammatory neuropathy pain are created both acutely and chronically through glial and proinflammatory cytokine actions...
  4. ncbi Continuous venovenous hemofiltration with or without predilution regional citrate anticoagulation: a prospective study
    S Azam Nurmohamed
    Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands
    Blood Purif 25:316-23. 2007
    ..The aim of this study was to compare CVVH with and without regional citrate anticoagulation (RCA) with respect to filter life, azotemic control and cost...
  5. ncbi Studies of propionate toxicity in Salmonella enterica identify 2-methylcitrate as a potent inhibitor of cell growth
    A R Horswill
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706 1567, USA
    J Biol Chem 276:19094-101. 2001
    ..This result lent further support to the in vivo data, which suggested that citrate synthase was the source of a toxic metabolite...
  6. ncbi Continuous venovenous hemofiltration with citrate-based replacement fluid: efficacy, safety, and impact on nutrition
    Azra Bihorac
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Kidney Dis 46:908-18. 2005
    ..We used volumes of 72 L/d in patients at high risk for bleeding and investigated the treatment's efficacy, safety, and clinical results, especially with regard to nutrition supplementation...
  7. ncbi Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain
    Stefan Kölker
    Department of General Pediatrics, Division of Metabolic and Endocrine Diseases, University Children s Hospital Heidelberg, D 69120 Heidelberg, Germany
    J Biol Chem 278:47388-93. 2003
    ..Inhibition of respiratory chain and tricarboxylic acid cycle is most likely induced by synergistically acting alternative metabolites, in particular 2-methylcitric acid, malonic acid, and propionyl-CoA...
  8. pmc In Salmonella enterica, 2-methylcitrate blocks gluconeogenesis
    Christopher J Rocco
    Department of Bacteriology, University of Wisconsin, 1550 Linden Dr, Madison, WI 53706 1521, USA
    J Bacteriol 192:771-8. 2010
    ..Our findings may help explain human inborn errors in propionate metabolism...
  9. pmc Characterization of pyoverdine and achromobactin in Pseudomonas syringae pv. phaseolicola 1448a
    Jeremy G Owen
    School of Biological Sciences, Victoria University of Wellington, Kelburn Parade, PO Box 600, Wellington 6140, New Zealand
    BMC Microbiol 11:218. 2011
    ..P. syringae 1448a also appears to have the genetic potential to make two secondary siderophores, achromobactin and yersiniabactin, each of which has previously been detected in different P. syringae pathovars...
  10. ncbi Urinary citrate and renal stone disease: the preventive role of alkali citrate treatment
    Renata Caudarella
    Centro Studi del Metabolismo Minerale, Fondazione Villa Maria, Lugo, Ravenna, Italy
    Arch Ital Urol Androl 81:182-7. 2009
    ..Nevertheless, the evaluation of urinary citrate in patients with kidney stones and the treatment of these patients with alkali salts namely with potassium citrate are still scarce...
  11. ncbi Regional citrate anticoagulation in continuous venovenous hemodiafiltration
    D J Kutsogiannis
    Division of Critical Care Medicine, The University of Alberta, Edmonton, Canada
    Am J Kidney Dis 35:802-11. 2000
    ..091/person-day on citrate anticoagulation (95% CI, 0.03 to 0.23). Guiding regional citrate anticoagulation through the use of posthemofilter ionized calcium levels is a safe and effective method of prolonging filter life during CVVHDF...
  12. ncbi Inhibition of calcium phosphate-DNA coprecipitates induced cell death by phosphocitrates
    Yubo Sun
    Rheumatology and Immunology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Front Biosci 10:803-8. 2005
    ....
  13. ncbi A safe citrate anticoagulation protocol with variable treatment efficacy and excellent control of the acid-base status
    Stanislao Morgera
    Departmentsof Nephrology, University Hospital Charité Campus Mitte, Berlin, Germany
    Crit Care Med 37:2018-24. 2009
    ..In this article, we provide a safe and an easy-to-handle citrate anticoagulation protocol with variable treatment doses and excellent control of the acid-base status...
  14. ncbi Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus
    Federico C Beasley
    Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada N6A 5C1
    Mol Microbiol 72:947-63. 2009
    ..The crystal structure of apo-HtsA was determined and identified a large positively charged region in the substrate-binding pocket, in agreement with a role in binding of anionic staphyloferrin A...
  15. ncbi Influence of root-surface conditioning with acid and chelating agents on clot stabilization
    Fabio Renato Manzolli Leite
    Department of Semilogy and Clinics, School of Dentistry, Federal University of Pelotas UFPel Pelotas, Rio Grande do Sul, Brazil
    Quintessence Int 41:341-9. 2010
    ..To compare the adhesion and maturation of blood components on chemically conditioned root surfaces...
  16. pmc Roles of the glyoxylate and methylcitrate cycles in sexual development and virulence in the cereal pathogen Gibberella zeae
    Seung Ho Lee
    Department of Agricultural Biotechnology, Centers for Fungal Pathogenesis and Agricultural Biomaterials, Seoul National University, South Korea
    Eukaryot Cell 8:1155-64. 2009
    ..zeae. Thus, both GzICL1 and GzMCL1 may play important roles in determining major mycological and pathological traits of G. zeae by participating in different metabolic pathways for the use of fatty acids...
  17. pmc ACP Best Practice No 181: Chemical pathology clinical investigation and management of nephrolithiasis
    T M Reynolds
    Clinical Chemistry Department, Queen s Hospital, Burton on Trent, Staffordshire, UK
    J Clin Pathol 58:134-40. 2005
    ..Then specific pharmacological treatment to modify urine calcium, oxalate, urate, citrate, and acidity are considered. Finally, more unusual types of stone are examined...
  18. pmc Staphylococcus aureus transporters Hts, Sir, and Sst capture iron liberated from human transferrin by Staphyloferrin A, Staphyloferrin B, and catecholamine stress hormones, respectively, and contribute to virulence
    Federico C Beasley
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Infect Immun 79:2345-55. 2011
    ..Experiments involving mice challenged intravenously with wild-type S. aureus and isogenic mutants demonstrated that the combination of Hts, Sir, and Sst transport systems was required for full virulence of S. aureus...
  19. ncbi The use of regional citrate anticoagulation for continuous venovenous hemodiafiltration in acute kidney injury
    Marcelino S Durão
    Intensive Care Unit, Nephrology Support Group, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Crit Care Med 36:3024-9. 2008
    ..We evaluated the data of 143 patients with acute kidney injury subjected to citrate-based continuous venovenous hemodiafiltration...
  20. ncbi Impact of preservation solution on the extent of blood-air barrier damage and edema formation in experimental lung transplantation
    Christian Mühlfeld
    Institute of Anatomy, University of Bern, Bern, Switzerland
    Anat Rec (Hoboken) 290:491-500. 2007
    ..Celsior was not effective in preserving the lung from morphological I/R injury...
  21. ncbi Measurement of glomerular filtration rate with chromium-51 ethylene diamino tetraacetic acid in the presence of gallium-67 citrate: a novel method for the solution of the problem
    Georgios Arsos
    Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Hippokration Hospital, Greece
    Nucl Med Commun 32:221-6. 2011
    ..This method was developed to solve a clinical problem and then it was validated by a controlled ⁶⁷Ga contamination of plasma samples with known counts from ⁵¹Cr-ethylene diamino tetraacetic acid...
  22. ncbi Citrate in urine determined with a new citrate lyase method
    M Petrarulo
    Renal Stone Laboratory, Mauriziano Umberto I Hospital, Turin, Italy
    Clin Chem 41:1518-21. 1995
    ..2%, imprecision (CV) of the assay for citrate at 0.96 mmol/L (urine) was 2.0%, and the lower limit of quantification was 0.08 mmol/L. Results correlated well with those by both ion-chromatographic and traditional citrate lyase methods...
  23. ncbi Phosphocitrate as a potential therapeutic strategy for crystal deposition disease
    H S Cheung
    Research Service, Miami VA Medical Center, FL 33125, USA
    Curr Rheumatol Rep 3:24-8. 2001
    ..Approaches that may ameliorate the degenerative process may ensue from new information about how crystals form and how they exert their biologic effects...
  24. ncbi Fibroblasts from mice with progessive ankylosis proliferate excessively in response to transforming growth factor-beta 1
    H E Krug
    Department of Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    J Investig Med 46:134-9. 1998
    ..We hypothesized that TGF-beta might be involved in the pathogenesis of MPA...
  25. ncbi Retrograde flush perfusion with low-potassium solutions for improvement of experimental pulmonary preservation
    T Wittwer
    Department of Cardiac Surgery, Thoracic and Vascular Surgery, Friedrich Schiller University, Jena, Germany
    J Heart Lung Transplant 19:976-83. 2000
    ..So far, we have seen no experimental studies that include stereologic analysis of intrapulmonary edema concerning the influence of retrograde preservation on post-ischemic lung function after preservation with Perfadex and Celsior...
  26. ncbi Evening primrose oil supplementation increases citraturia and decreases other urinary risk factors for calcium oxalate urolithiasis
    Allen Rodgers
    Department of Chemistry, University of Cape Town, Cape Town, South Africa
    J Urol 182:2957-63. 2009
    ..We investigated the effects of gamma-linolenic acid (an omega-6 polyunsaturated fatty acid) in the form of evening primrose oil on calcium oxalate urinary stone risk factors in 2 ethnic groups...
  27. ncbi Citric acid or citrates in urine: which should we focus on in the prevention of calcium oxalate crystals and stones?
    Norbert Laube
    Division of Experimental Urology, Department of Urology, Bonn University, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Urol Res 30:336-41. 2002
    ..48 mmol/l...
  28. ncbi Evidence for suppression of electroacupuncture on spinal glial activation and behavioral hypersensitivity in a rat model of monoarthritis
    S Sun
    Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
    Brain Res Bull 75:83-93. 2008
    ..These data suggested that analgesic effects of EA might be associated with its counter-regulation to spinal glial activation, and thereby provide a potential strategy for the treatment of arthritis...
  29. ncbi Effect of anticoagulation on blood membrane interactions during hemodialysis
    R Hofbauer
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Kidney Int 56:1578-83. 1999
    ....
  30. ncbi Role of spinal microglia in rat models of peripheral nerve injury and inflammation
    Anna K Clark
    Neurorestoration, Wolfson Centre for Age Related Diseases, King s College London, Wolfson Wing, Hodgkin Building, Guys Campus, London SE1 1UL, UK
    Eur J Pain 11:223-30. 2007
    ..Furthermore, it would appear that the time course of microglia activation and their contribution to inflammatory pain is dependent on the inflammatory stimulus administered...
  31. ncbi Reduction of renal stone risk by potassium-magnesium citrate during 5 weeks of bed rest
    Joseph E Zerwekh
    Center for Mineral Metabolism and Clinical Research, and the Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Urol 177:2179-84. 2007
    ..This study was performed to evaluate the efficacy of potassium alkali as potassium-magnesium citrate in reducing renal stone risk and bone turnover...
  32. ncbi Comparison between Perfadex and locally manufactured low-potassium dextran solution for pulmonary preservation in an ex vivo isolated lung perfusion model
    P R O Soares
    Laboratory of Thoracic Surgery Research, Department of Cardiopneumology, InCor, Clinics Hospital, University of Sao Paulo, Medical School, Sao Paulo, Brazil
    Transplant Proc 43:84-8. 2011
    ..We sought the local development of LPD solutions in an attempt to facilitate access and enhance usage. We also sought to evaluate the effectiveness of a locally manufactured LPD solution in a rat model of ex vivo lung perfusion...
  33. ncbi Citrate anticoagulation in continuous venovenous hemodiafiltration: a metabolic challenge
    Luca Gabutti
    Department of Internal Medicine, Ospedale la Carità Locarno, Locarno, Switzerland
    Intensive Care Med 28:1419-25. 2002
    ..Feasibility and safety evaluation of regional citrate anticoagulation (RCA) versus systemic heparinization for continuous venovenous hemodiafiltration...
  34. pmc Chromosomal mutation for citrate utilization by Escherichia coli K-12
    B G Hall
    J Bacteriol 151:269-73. 1982
    ..It is capable of utilizing cis- and trans-aconitate, but only if it is preinduced by growth on citrate...
  35. ncbi Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus
    Johnson Cheung
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Mol Microbiol 74:594-608. 2009
    ....
  36. ncbi 2-Methylcitrate-dependent activation of the propionate catabolic operon (prpBCDE) of Salmonella enterica by the PrpR protein
    Sergio Palacios
    Department of Bacteriology, University of Wisconsin, 1710 University Avenue, Madison, WI 53726 4087, USA
    Microbiology 150:3877-87. 2004
    ..Analysis of the binding-site sequence revealed two sites with dyad symmetry. Results from DNase I footprinting assays suggested that the PrpR protein may have higher affinity for the site proximal to the P(prpBCDE) promoter...
  37. pmc Impact of siderophore production by Pseudomonas syringae pv. syringae 22d/93 on epiphytic fitness and biocontrol activity against Pseudomonas syringae pv. glycinea 1a/96
    Annette Wensing
    School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
    Appl Environ Microbiol 76:2704-11. 2010
    ..syringae pv. syringae 22d/93 still suppressed development of bacterial blight caused by P. syringae pv. glycinea, siderophore production enhanced the epiphytic fitness and thus the competitiveness of the antagonist...
  38. pmc The Staphylococcus aureus siderophore receptor HtsA undergoes localized conformational changes to enclose staphyloferrin A in an arginine-rich binding pocket
    Jason C Grigg
    Department of Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 285:11162-71. 2010
    ..The conformational change is highlighted by isolated movement of three loops within the C-terminal domain, a domain movement unique to known class III binding protein structures...
  39. ncbi Basic calcium phosphate crystals stimulate the endocytotic activity of cells--inhibition by anti-calcification agents
    Yubo Sun
    Division of Rheumatology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    Biochem Biophys Res Commun 312:1053-9. 2003
    ....
  40. ncbi Phosphocitrate blocks calcification-induced articular joint degeneration in a guinea pig model
    Herman S Cheung
    VA Medical Center, Miami, Florida 33125, USA
    Arthritis Rheum 54:2452-61. 2006
    ..The present study was undertaken to examine the role of calcification in OA disease progression and to evaluate a formulation of phosphocitrate (PC) as a potential therapeutic agent...
  41. ncbi Disruption of glial function enhances electroacupuncture analgesia in arthritic rats
    Shan Sun
    Institute of Neurobiology, Fudan University, 220 Handan Road, Shanghai 200433, China
    Exp Neurol 198:294-302. 2006
    ..These results suggested that electroacupuncture and disrupting glial function could synergistically antagonize inflammatory pain, which might provide a potential strategy for the treatment of arthritic pain...
  42. ncbi Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines
    E D Milligan
    Department of Psychology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0345, USA
    J Neurosci 21:2808-19. 2001
    ..These results support the concept that activated glia in dorsal spinal cord can create exaggerated pain states via the release of proinflammatory cytokines...
  43. ncbi Alkaline citrate reduces stone recurrence and regrowth after shockwave lithotripsy and percutaneous nephrolithotomy
    B Lojanapiwat
    Division of Urology and Department of Surgery, Chiangmai University, Thailand
    Int Braz J Urol 37:611-6. 2011
    ..To evaluate the preventive effects of alkaline citrate on stone recurrence as well as stone growth post-ESWL or PCNL in patients with calcium-containing stones...
  44. ncbi Effects of sennosides and nonanthranoid laxatives on cytochemistry of epithelial cells in rat colon
    K Yang
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, N Y 10021
    Pharmacology 47:196-204. 1993
    ..Cytokeratin AE1 expression increased on picosulfate and sennosides. SBA total binding increased on bisacodyl and picosulfate. The present findings were thought to be of functional origin and do not represent early precancerous lesions...
  45. ncbi Phosphocitrate inhibits calcium hydroxyapatite induced mitogenesis and upregulation of matrix metalloproteinase-1, interleukin-1beta and cyclooxygenase-2 mRNA in human breast cancer cell lines
    Michelle M Cooke
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Breast Cancer Res Treat 79:253-63. 2003
    ....
  46. ncbi Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats
    Mohammad Asghar
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA
    Mol Cell Biochem 304:93-9. 2007
    ..Therefore, HCA-SX may be used as an intervention to overcome obesity-related complications, including inflammation, oxidative stress, and insulin resistance...
  47. ncbi Siderophore-mediated iron acquisition in the staphylococci
    Federico C Beasley
    Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    J Inorg Biochem 104:282-8. 2010
    ..This review summarizes our current knowledge of siderophore-mediated iron acquisition systems in the genus Staphylococcus...
  48. pmc Specificity of Staphyloferrin B recognition by the SirA receptor from Staphylococcus aureus
    Jason C Grigg
    Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada and
    J Biol Chem 285:34579-88. 2010
    ..Although both SirA and HtsA bind siderophores from the same α-hydroxycarboxylate class, the unique structural features of each receptor provides an explanation for their distinct specificity...
  49. pmc Ralstonia solanacearum iron scavenging by the siderophore staphyloferrin B is controlled by PhcA, the global virulence regulator
    Garima Bhatt
    Department of Plant Pathology, University of Georgia, Athens, GA 30602, USA
    J Bacteriol 186:7896-904. 2004
    ..AW1 did not produce siderophore activity when cultured in tomato xylem sap, suggesting that the main location in tomato for R. solanacearum during pathogenesis is iron replete...
  50. ncbi Formations of mixed-valence oxovanadiumV,IV citrates and homocitrate with N-heterocycle chelated ligand
    Can Yu Chen
    State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China
    Inorg Chem 47:8714-20. 2008
    ..H 2O ( 5), form strong hydrogen bonds with the chloride ion and the water molecule [2.982(5) in 3, 2.562(9) in 4, and 2.763(1) A in 5], respectively...
  51. pmc Analysis of achromobactin biosynthesis by Pseudomonas syringae pv. syringae B728a
    Andrew D Berti
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Bacteriol 191:4594-604. 2009
    ..This work provides insights into the biosynthetic steps in the formation of achromobactin and is the first in vitro reconstitution of achromobactin biosynthesis...
  52. ncbi A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases
    Gregory L Challis
    Department of Chemistry, Warwick University, Coventry CV4 7AL, UK
    Chembiochem 6:601-11. 2005
  53. ncbi Pathophysiology of hypocitraturic nephrolithiasis
    L Lee Hamm
    Section of Nephrology and Hypertension, Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Endocrinol Metab Clin North Am 31:885-93, viii. 2002
    ..In addition, oral citrate as an alkalinizing agent can not only increase urinary citrate, but also favorably impact other stone-promoting conditions. This review will focus on the understanding of these concepts...
  54. ncbi Hydroxycitrate has long-term effects on feeding behavior, body weight regain and metabolism after body weight loss in male rats
    Monika Leonhardt
    Institute of Animal Sciences, Swiss Federal Institute of Technology, CH 8603 Schwerzenbach, Switzerland
    J Nutr 132:1977-82. 2002
    ..The fact that HCA did not change plasma BHB concentration does not support a role for increased hepatic fatty acid oxidation in the anorectic effect of HCA...
  55. ncbi Effect of astrocytic energy metabolism depressant on 14C-acetate uptake in intact rat brain
    Rie Hosoi
    School of Allied Health Sciences, Faculty of Medicine, Osaka University, Suita, Osaka, Japan
    J Cereb Blood Flow Metab 24:188-90. 2004
    ..The present observations indicate that 14C-acetate uptake might be a useful characteristic for examining astrocytic energy metabolism in the intact brain...
  56. ncbi Effect of K-252a and abscisic acid on the efflux of citrate from soybean roots
    Hong Shen
    Research Institute for Bioresources, Okayama University, 2 20 1 Chuo, Kurashiki 710 0046, Japan
    J Exp Bot 55:663-71. 2004
    ....
  57. ncbi Citrate pharmacokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients
    Ludwig Kramer
    Department of Medicine IV, University of Vienna Medical School, Austria
    Crit Care Med 31:2450-5. 2003
    ..To investigate pharmacokinetics and metabolism of sodium citrate in critically ill patients. To determine the risk of citrate accumulation in the setting of liver dysfunction (cirrhosis, hepatorenal syndrome)...
  58. pmc Safety and efficacy of regional citrate anticoagulation during 8-hour sustained low-efficiency dialysis
    John A Clark
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Clin J Am Soc Nephrol 3:736-42. 2008
    ..A safe and simple "regional" anticoagulation strategy would be beneficial. The modification of existing regional citrate anticoagulation protocols to typically performed 8-h sustained low-efficiency dialysis is necessary...
  59. ncbi The methylcitric acid pathway in Ralstonia eutropha: new genes identified involved in propionate metabolism
    C O Brämer
    Institut fur Mikrobiologie, Westfalische Wilhelms Universitat Munster, Corrensstrasse 3, D 48149 Munster, Germany
    Microbiology 147:2203-14. 2001
    ..Since the prp locus of R. eutropha was very different from those of E. coli and S. enterica, an extensive comparison of prp loci available from databases and literature was done, revealing two different classes of prp loci...
  60. pmc Partial purification and regulatory properties of phosphofructokinase from Aspergillus niger
    A Habison
    Biochem J 209:669-76. 1983
    ....
  61. ncbi Metabolic engineering of strains of Ralstonia eutropha and Pseudomonas putida for biotechnological production of 2-methylcitric acid
    Christian Ewering
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Metab Eng 8:587-602. 2006
    ..putida DeltaacnM(Pp)OmegaKmprpC(Re) and R. eutropha DeltaacnM(Re)OmegaKmprpC(Pp) produced 2MC up to maximal concentrations of 7.2 g/L or 26.5 mM and 19.2 g/L or 70.5 mM, respectively, during 144 h of cultivation...
  62. ncbi Sodium citrate anticoagulation during sustained low efficiency dialysis (SLED) in patients with acute renal failure and severely impaired liver function
    Christian Morath
    Nephrol Dial Transplant 23:421-2. 2008
  63. ncbi Citrate kinetics in patients receiving long-term hemodialysis therapy
    Edith Bauer
    Division of Nephrology, Medical Department III, Vienna General Hospital, Medical University of Vienna, Austria
    Am J Kidney Dis 46:903-7. 2005
    ..This study compares the pharmacokinetics of citrate in hemodialysis patients with minimal residual function with that in patients with normal renal function...
  64. ncbi Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat
    L R Watkins
    Department of Psychology, University of Colorado at Boulder, 80309, USA
    Pain 71:225-35. 1997
    ..Taken together, the present series of experiments suggest an important role for spinal glial cells in the cascade of events that are initiated by descending signals following s.c. administration of formalin...
  65. ncbi Intrathecal administration of ATP produces long-lasting allodynia in rats: differential mechanisms in the phase of the induction and maintenance
    T Nakagawa
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Neuroscience 147:445-55. 2007
    ....
  66. ncbi The configuration of the chiral carbon atoms in staphyloferrin A and analysis of the transport properties in Staphylococcus aureus
    Hartmut Drechsel
    Institut fur Mikrobiologie, Mikrobiologie and Biotechnologie, Universitat Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Biometals 18:75-81. 2005
    ..Growth promotion tests with staphylococci revealed that the S,S-configuration of staphyloferrin A and enantio-rhizoferrin enabled iron uptake, while the fungal rhizoferrin with R,R-configuration was not utilized...
  67. ncbi Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A
    Jennifer L Cotton
    Department of Infectious Diseases, Novartis Institutes for BioMedical Research, 500 Technology Square, Cambridge, Massachusetts 02139, USA
    Biochemistry 48:1025-35. 2009
    ....
  68. ncbi Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis
    Ty A Gould
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843, USA
    Mol Microbiol 61:940-7. 2006
    ..Furthermore, the crystal structure of ICL1 with pyruvate and succinate bound demonstrates that the active site can accommodate the additional methyl group without significant changes to the structure...
  69. ncbi Erwinia chrysanthemi requires a second iron transport route dependent of the siderophore achromobactin for extracellular growth and plant infection
    Thierry Franza
    Laboratoire de Pathologie Végétale, UMR 217 INRA INA P G UPMC, 16 rue Claude Bernard, 75005 Paris, France
    Mol Microbiol 55:261-75. 2005
    ..Interestingly, iron transport mediated by achromobactin or a closely related siderophore probably exists in other phytopathogenic bacterial species such as Pseudomonas syringae...
  70. ncbi Improvement of pulmonary preservation with Celsior and Perfadex: impact of storage time on early post-ischemic lung function
    T Wittwer
    Department of Cardiothoracic and Vascular Surgery, Hannover Medical School, Germany
    J Heart Lung Transplant 18:1198-201. 1999
    ..Optimal preservation of post-ischemic organ function is a continuing challenge in clinical lung transplantation...
  71. pmc Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle
    Wilfried A Claes
    Lehrstuhl fur Genetik, Fakultat fur Biologie, Universitat Bielefeld, Postfach 100131, 33501 Bielefeld, Germany
    J Bacteriol 184:2728-39. 2002
    ..Mutational analyses revealed that only the prpD2B2C2 genes were essential for the growth of C. glutamicum on propionate as a sole carbon source, while the function of the prpD1B1C1 genes remains obscure...
  72. pmc Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors
    Kohei Shimizu
    Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 5:75. 2009
    ....
  73. ncbi Thermodynamic boundary conditions suggest that a passive transport step suffices for citrate excretion in Aspergillus and Penicillium
    Wolfgang Burgstaller
    Institute of Microbiology, Technikerstrasse 25, A 6020 Innsbruck, Austria
    Microbiology 152:887-93. 2006
    ..niger at an extracellular pH of 3 and by Penicillium simplicissimum at an extracellular pH of 7. From the results of these calculations it is concluded that in both cases a passive transport step suffices for citrate excretion...
  74. ncbi Adult-onset Still's disease: evaluation by gallium-67 citrate scintigraphy
    Tohru Takeshita
    Department of Radiology, Teikyo University School of Medicine, Kaga, Tokyo
    Intern Med 45:937-8. 2006
  75. ncbi [67-Gallium citrate gammagraphy in the study of lymphomas]
    Y Ricart
    Rev Esp Med Nucl 21:85-7. 2002
  76. ncbi Detection of acute postoperative mediastinitis in mice using (99m)Tc-liposomes
    Dimitrios Andreopoulos
    University of Texas M D Anderson Cancer Center, Houston, Texas From the Baylor College of Medicine, the Methodist, Houston, Texas 77030 4009, USA
    Invest Radiol 37:435-9. 2002
    ..To evaluate the usefulness of size-modified (99m)Tc-labeled liposomes for the detection of acute postoperative mediastinitis in a mouse model...
  77. ncbi Detection of a stomach gastrointestinal stromal tumor in situs invertus by gallium-67 scintigraphy
    Jong Kang Lee
    Department of Nuclear Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    Clin Nucl Med 31:425-8. 2006
  78. ncbi Applications of nuclear medicine in pediatric oncology
    Leonard P Connolly
    Division of Nuclear Medicine, Department of Radiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Nucl Med 27:117-25. 2002
    ..Imaging strategies for staging and monitoring the therapeutic response of Hodgkin's lymphoma include Ga-67 citrate scintigraphy. Pediatric oncologic applications of positron emission tomography are being investigated extensively...
  79. ncbi [Pulmonary activity in sarcoidosis: 67Ga uptake quantification and plasma determination of 1,25-dihydroxyvitamin D)]
    J R Infante
    Servicio de Medicina Nuclear, Hospital Universitario Reina Sofia, Cordoba, Spain
    Rev Esp Med Nucl 21:275-80. 2002
    ..The aim of our study was to produce a quantitative determination of Ga-67 pulmonary intake and correlate it with plasma levels of calcitriol...
  80. ncbi Ga-67 scintigraphy in patients with breast lymphoma
    Yoshihiro Nishiyama
    Department of Radiology, Faculty of Medicine, Kagawa Medical University, Kita gun, Kagawa, Japan
    Clin Nucl Med 27:101-4. 2002
    ..The authors studied the utility of Ga-67 citrate scintigraphy in patients with breast lymphoma...
  81. ncbi Clinical impact of whole body FDG-PET on the staging and therapeutic decision making for malignant lymphoma
    Masayuki Sasaki
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Nucl Med 16:337-45. 2002
    ..The aim of this study is to evaluate the clinical impact of whole-body FDG-PET for the pre-therapeutic evaluation of malignant lymphoma and compared to that of 67Ga-scintigraphy when added to non-RI examinations...
  82. ncbi Differentiation of low-grade gastric MALT lymphoma and high-grade gastric MALT lymphoma: the clinical value of Ga-67 citrate scintigraphy--a pilot study
    Chang Hu Hsu
    Division of Gastroenterology, China Medical College Hospital, Taichung, Taiwan
    Cancer Invest 20:939-43. 2002
    ..However, further investigation is needed to understand the relationship between the uptake of Ga-67 citrate in gastric MALT lymphoma and transformation...
  83. ncbi Collimator optimization for detection and quantitation tasks: application to gallium-67 imaging
    Stephen C Moore
    Division of Nuclear Medicine, Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    IEEE Trans Med Imaging 24:1347-56. 2005
    ....
  84. ncbi [SPECT for diagnosis of brain tumors]
    Atsushi Abe
    Department of Radiology, Saitama Medical Center
    Nihon Rinsho 63:236-41. 2005
  85. ncbi Radiopharmaceuticals to image infection and inflammation
    O C Boerman
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Semin Nucl Med 31:286-95. 2001
    ..In this article, the characteristics and diagnostic potential of established and experimental radiopharmaceuticals for infection and inflammation imaging are reviewed...
  86. ncbi [Effectiveness of (67)Ga scintigraphy in the diagnosis of lymphoma relapse]
    S Alvarez Ruiz
    Servicio de Medicina Nuclear, Hospital Santiago Apostol, Vitoria, Spain
    Rev Esp Med Nucl 21:88-92. 2002
    ..To establish the clinical effectiveness of 67Ga in lymphoma recurrence...
  87. ncbi Gallium citrate uptake is a marker of breast malignancy: true or false?
    Muhammed A Taher
    Department of Nuclear Medicine, Royal Free Hospital, London, UK
    Nucl Med Rev Cent East Eur 10:21-2. 2007
    ..Though uptake of (67)Gallium citrate is normally associated with malignancy or infection there may be other causes of uptake and follow-up biopsy should be performed...
  88. ncbi Negative gallium-67 citrate and positive positron emission tomography/computed tomography spleen scans, in Hodgkin's stage IV lymphoma
    Julia Malamitsi
    PET CT Department, Diagnostic and Therapeutic Center of Athens Hygeia, Harvard Medical International, Athens, Greece
    Hell J Nucl Med 10:116-8. 2007
    ..Massive infiltration of the spleen by HL-IVB tissue was confirmed by pathology after splenectomy. Two successive PET/CT studies for follow-up purposes three and twelve months after completion of chemotherapy, were normal...
  89. ncbi Recent advances in the diagnosis and therapy of Richter's syndrome
    Ronan Swords
    Department of Haematology, University College Hospital Galway, Galway, Ireland
    Med Oncol 24:17-32. 2007
    ..This review will address the current status of RS and deal with the pathophysiology, diagnostic approach, and treatment of this challenging disease...
  90. ncbi Gallium and other agents in diseases of the lung
    David M Schuster
    Emory University Hospital and Atlanta Veterans Affairs Medical Center, Atlanta, GA 30322, USA
    Semin Nucl Med 32:193-211. 2002
    ....
  91. ncbi The value of Tc-99m (V) dimercaptosuccinic acid in detecting intra-abdominal infection: compared with gallium scan
    Wan Yu Lin
    Department of Nuclear Medicine, Taichung Veterans General Hospital, 160 Taichung Harbor Road, Section 3, Taichung, Taiwan
    Ann Nucl Med 21:285-91. 2007
    ..Tc-99m (V) DMSA is inexpensive, easy to prepare, and provides a result within hours. In this study, we evaluated the potential of Tc-99m (V) DMSA scan (DMSA scan) in the detection of intra-abdominal infection...
  92. ncbi Transient adrenal gland uptake of gallium during septicemia
    Lawrence Parker
    Endocrinology Section, Cancer Program, and Molecular and Diagnostic Health Care Group, Department of Veterans Affairs Medical Center, Long Beach, CA 90822, USA
    Semin Nucl Med 32:217-9. 2002
  93. ncbi [Pubis osteomyelitis in adolescent as cause of fever with unknown focus]
    I Martinez-Rodriguez
    Servicio de Medicina Nuclear, Hospital Universitario Marques de Valdecilla, Universidad de Cantabria, Santander, Spain
    Rev Esp Med Nucl 26:171-2. 2007
  94. ncbi Scintigraphic pattern of planar gallium scan in wound infection after colorectal surgery
    S C Tsai
    Department of Nuclear Medicine, Show Chwan Memorial Hospital, 542, Section 1, Chungshan Road, Changhua, Taiwan
    Abdom Imaging 27:442-7. 2002
    ..No studies have evaluated the usefulness of gallium 67 scintigraphy for detecting wound infection after colorectal surgery. We investigated the clinical potential of gallium imaging for detecting wound infection after colorectal surgery...
  95. ncbi Study on the usefulness of whole body SPECT coronal image, MIP image in 67Ga scintigraphy
    Seiji Kawamura
    Center for Diagnostic Imaging, Kurume University Hospital, Fukuoka, Japan
    Ann Nucl Med 16:221-6. 2002
    ..Our data suggest that whole body SPECT is an excellent technique as an alternative to WB/SC...
  96. ncbi Usefulness of 67Ga SPECT and integrated low-dose CT scanning (SPECT/CT) in the diagnosis of cardiac sarcoidosis
    Mitsuhiro Momose
    Department of Radiology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    Ann Nucl Med 21:545-51. 2007
    ....
  97. ncbi Late computed tomography scan response improvement and gallium scintigraphy evaluation as on-treatment prognostic parameters to tailor treatment intensity in patients with Hodgkin's lymphoma. A prospective phase II study
    A Re
    U O Ematologia, Spedali Civili di Brescia, Brescia, Italy
    Ann Oncol 19:951-7. 2008
    ..Ongoing prognostic parameters may be an useful adjunct to pretreatment stratification. We used the kinetics of computed tomography (CT) scan response and residual gallium (Ga)-67 uptake to better stratify risk...
  98. ncbi Comparison of 18F-FDG and 67Ga-citrate in sarcoidosis imaging
    E Prager
    Division of Nuclear Medicine, Medical University of Graz, Auenbruggerplatz 9, 8036 Graz, Austria
    Nuklearmedizin 47:18-23. 2008
    ..This study aimed to analyze possible advantages of (18)F-FDG-PET over (67)Ga citrate scintigraphy during the primary assessment of patients with sarcoidosis...
  99. ncbi Role of serial quantitative gallium-67 tumor uptake in assessing response rates for chemotherapy in lymphoma patients
    Nasser S Ballani
    aNuclear Medicine Department bOncology Department, Centre for Specialised Surgery, Kuwait cBiomedical Sciences Department, Lebanese International University, Beirut, Lebanon
    Nucl Med Commun 29:527-34. 2008
    ..To evaluate in serial gallium-67 scans (GS) the role of semiquantitative tumor-to-background (Tm/Bg) and tumor-to-liver ratios in assessing response rates to chemotherapy, in Hodgkin's disease and non-Hodgkin's lymphoma...
  100. ncbi 18F-FDG hybrid PET in patients with suspected spondylitis
    S Gratz
    Department of Nuclear Medicine, Georg August University of Gottingen, Germany
    Eur J Nucl Med Mol Imaging 29:516-24. 2002
    ....
  101. ncbi Evaluation of high-risk melanoma: comparison of [18F]FDG PET and high-dose 67Ga SPET
    Victor Kalff
    The Department of Diagnostic Imaging, The Peter MacCallum Cancer Institute, 12 Cathedral Place, East Melbourne, Victoria, 3002 Australia
    Eur J Nucl Med Mol Imaging 29:506-15. 2002
    ....

Research Grants36

  1. MOLECULAR MECHANISM OF RENAL NA+ DEPENDENT COTRANSPORT
    Ana M Pajor; Fiscal Year: 2010
    ..Understanding how NaDC1 and SdcS work will help us to develop treatments for NaDC1-mediated diseases. ..
  2. BIOLOGICAL EFFECTS OF BASIC CALCIUM PHOSPHATE CRYSTALS
    Herman Cheung; Fiscal Year: 2004
    ..Hypothesis 5: There are specific cis elements in the promotor of Tissue Inhibitor of Metalloproteinase (TIMP)-2 that regulate crystal inhibition of TIMP- 2 expression. ..
  3. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2009
    ..Overall, this project will determine the relationship between the NO and the oxygen consumption in the hearts subjected to PC and HT and provide insight into the actual mechanism of cardioprotection. ..
  4. Novel Risk Factors for Kidney Stone Formation
    Eric Taylor; Fiscal Year: 2008
    ..At the completion of this career development award, Dr. Taylor will have a unique combination of skills and experience that will enable him to succeed as an independent clinical investigator. ..
  5. Mentored Patient-Oriented Research Career Development Aw
    Christina Bergqvist; Fiscal Year: 2004
    ....
  6. Microxymetry Techniques for Cardiomocyte Respiration
    Govindasamy Ilangovan; Fiscal Year: 2005
    ..Overall, by establishing this new technique, it is possible to simultaneously measure the oxygen consumption and ROS production in microliter volumes of cellular and sub-cellular components. ..
  7. Cellular Targets for Gallium Compounds in Lymphoma
    Christopher Chitambar; Fiscal Year: 2008
    ..Our studies will provide new information regarding: a) the impact of HFE mutations on the response of lymphoma to gallium, and, b) the mechanism of action of gallium at the mitochondrial level. ..
  8. MRI Visceral Adipose Tissue Partitioning:Advanced Models
    Steven Heymsfield; Fiscal Year: 2005
    ..Our findings could help to set new standards for VAT and adipose tissue subcompartment measurement, lower the cost of MRI body composition studies, and improve study power. ..
  9. UNIQUE ASPARTATE TRANSPORT IN PROSTATE
    LESLIE COSTELLO; Fiscal Year: 2005
    ..abstract_text> ..
  10. TISSUE STRESS VARIABILITY AND STRENGTH IN VERTEBRAL BONE
    Yener Yeni; Fiscal Year: 2006
    ..abstract_text> ..
  11. Coronary calcification in hemodialysis patients
    William Goodman; Fiscal Year: 2005
    ....
  12. Functional Tissue Factor on Activated Endothelium
    Eric Grabowski; Fiscal Year: 2004
    ....
  13. Nitric Oxide Cytotoxicity and Iron-Sulfur Proteins
    Huangen Ding; Fiscal Year: 2009
    ..The proposed research, if successful, will provide fundamental knowledge for developing therapeutic approaches to prevent or alleviate cellular oxidative damages inflicted by NO cytotoxicity. ..
  14. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  15. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ....
  16. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  17. INDICES OF BIOTIN NUTRITION
    Donald Mock; Fiscal Year: 2001
    ..4) Whether biotin deficiency of similar severity to that observed either early or late in human gestation causes increased rates of fetal malformation in the mouse. 5) The enzyme(s) responsible for biotin beta-oxidation. ..
  18. Involvement of Na/Dicarboxylate Cotransporter in Aging
    Ana Pajor; Fiscal Year: 2002
    ..abstract_text> ..
  19. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  20. SPECT Scanner for Molecular Biology and Imaging Research
    Stephen Moore; Fiscal Year: 2002
    ..Army, the Massachusetts Department of Public Health, the American Cancer Society, and the Dana Foundation. ..
  21. RESEARCH TRAINING IN IMAGING METHODS FOR CANCER
    Stephen Moore; Fiscal Year: 2002
    ..Some didactic course work is offered at Harvard Medical School, Harvard School of Public Health, and Massachusetts Institute of Technology. The patient population includes those treated at Dana-Farber-Partners Cancer Care. ..
  22. PATHWAY(S) OF LEUKOCYTE EXTRAVASATION IN INFLAMMATION
    Ann Dvorak; Fiscal Year: 2001
    ..abstract_text> ..
  23. Induction of Tissue Factor by Patient Sera in HUS
    Eric Grabowski; Fiscal Year: 2007
    ..A key additional feature of this proposal is the use of our newly formed collaborative group of pediatric nephrologists to facilitate patient recruitment [unreadable] [unreadable]..
  24. A Longitudinal 3-D MRSI Study of Infants at High Risk for Autism
    Stephen R Dager; Fiscal Year: 2010
    ....
  25. IMPROVED QUANTITATIVE GA-65 SPECT IMAGING
    Stephen Moore; Fiscal Year: 2002
    ....
  26. REGULATION OF CITRATE TRANSPORT
    Lee Hamm; Fiscal Year: 2003
    ..abstract_text> ..
  27. Symphony Multiplex Peptide Synthesizer w/ VISION Workstn
    Kenneth Mann; Fiscal Year: 2004
    ..There is currently no preparative HPLC system on the campus of the University of Vermont and this system is badly needed for many investigators. ..
  28. BASOPHIL/MAST CELL FUNCTION
    Ann Dvorak; Fiscal Year: 2004
    ..assess the formation and function of endothelial cell VVO in allergic inflammation; 4. define the pathway(s) of endothelial cell diapedesis of basophils and eosinophils. ..
  29. BRAIN METABOLISM AND TREATMENT OUTCOME IN PANIC DISORDER
    Stephen Dager; Fiscal Year: 2004
    ..abstract_text> ..
  30. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2008
    ..The major aim of this project is to elucidate the structure/function relationships of this material with respect to factor V inactivation and to access its potential significance in the pathology of human thrombosis. ..
  31. Multiparametric MRI characterization of breast tissue
    Michael Jacobs; Fiscal Year: 2009
    ..abstract_text> ..
  32. PE BIOSYSTEMS VOYAGER DE MALDI-TOF
    Kenneth Mann; Fiscal Year: 2001
    ..The fulfillment of the specific aims described in detail in the twelve research proposals would be facilitated by the addiction of a Voyager-DE MALDI-TOF ..
  33. B12 Biosysthesis and Anaerobic Metabolism in Salmonella
    JORGE ESCALANTE; Fiscal Year: 2009
    ..Lastly, we will begin to dissect the biosynthetic pathways for the lower ligand base. One pathway is largely non-enzymatic while the other one is a piecemeal pathway. ..
  34. Summer Institute Preparation for Careers in Microbiology
    JORGE ESCALANTE; Fiscal Year: 2002
    ..The Institute is the first and only program of its kind providing students with hands-on, practical training in communications and teaching, ethics, grant preparation and review. ..