propionates

Summary

Top Publications

  1. ncbi The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    Andrew J Brown
    Department of 7TMR Systems Research, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    J Biol Chem 278:11312-9. 2003
  2. ncbi Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, Social Science Centre, London, Canada
    Behav Brain Res 176:149-69. 2007
  3. ncbi Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, London, Canada
    Behav Brain Res 217:47-54. 2011
  4. ncbi Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    Bodo Brueckner
    Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 65:6305-11. 2005
  5. ncbi The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Mol Aspects Med 28:375-95. 2007
  6. ncbi Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence
    Ernesto J Muñoz-Elías
    Laboratory of Infection Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Microbiol 60:1109-22. 2006
  7. pmc AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    Haihong Zong
    Howard Hughes Medical Institute and the Departments of Internal Medicine, Cell Biology, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15983-7. 2002
  8. ncbi Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders
    Raymond H Thomas
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Biology, University of Western Ontario, London, Ontario, Canada
    J Neurochem 113:515-29. 2010
  9. ncbi Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism
    Sandy R Shultz
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada
    Neuropharmacology 54:901-11. 2008
  10. pmc Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
    Ikuo Kimura
    Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:8030-5. 2011

Detail Information

Publications277 found, 100 shown here

  1. ncbi The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    Andrew J Brown
    Department of 7TMR Systems Research, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    J Biol Chem 278:11312-9. 2003
    ..The identity of the cognate physiological ligands for these receptors is not clear, although propionate is known to occur in vivo at high concentrations under certain pathophysiological conditions...
  2. ncbi Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, Social Science Centre, London, Canada
    Behav Brain Res 176:149-69. 2007
    ..Thus, intraventricular administration of PPA in rats may provide a means to model some aspects of human ASD in rats...
  3. ncbi Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, London, Canada
    Behav Brain Res 217:47-54. 2011
    ....
  4. ncbi Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    Bodo Brueckner
    Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 65:6305-11. 2005
    ..These results establish RG108 as a DNA methyltransferase inhibitor with fundamentally novel characteristics that will be particularly useful for the experimental modulation of epigenetic gene regulation...
  5. ncbi The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Mol Aspects Med 28:375-95. 2007
    ..In this review, we will provide an overview of Ape1/Ref-1's activities and explore the potential of this protein as a target in cancer treatment as well as its role in chemoprevention...
  6. ncbi Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence
    Ernesto J Muñoz-Elías
    Laboratory of Infection Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Microbiol 60:1109-22. 2006
    ..Paradoxically, bacterial growth and persistence, and tissue pathology, were indistinguishable in mice infected with wild-type or DeltaprpDC bacteria...
  7. pmc AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    Haihong Zong
    Howard Hughes Medical Institute and the Departments of Internal Medicine, Cell Biology, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15983-7. 2002
    ..These data demonstrate that by sensing the energy status of the muscle cell, AMPK is a critical regulator involved in initiating mitochondrial biogenesis...
  8. ncbi Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders
    Raymond H Thomas
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Biology, University of Western Ontario, London, Ontario, Canada
    J Neurochem 113:515-29. 2010
    ..These results provide evidence of a relationship between changes in brain lipid profiles and the occurrence of ASD-like behaviors using the autism rodent model. We propose that altered brain fatty acid metabolism may contribute to ASD...
  9. ncbi Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism
    Sandy R Shultz
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada
    Neuropharmacology 54:901-11. 2008
    ..These findings suggest that PPA can change both brain and behavior in the laboratory rat in a manner that is consistent with symptoms of human ASD...
  10. pmc Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
    Ikuo Kimura
    Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:8030-5. 2011
    ..These findings establish that SCFAs and ketone bodies directly regulate GPR41-mediated SNS activity and thereby control body energy expenditure in maintaining metabolic homeostasis...
  11. ncbi 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease
    Emmanuel Brouillet
    Centre Nationale de la Recherche Scientifique 2210, Service Hospitalier Frederic Joliot, Départment de Recherches Médicales, Direction des Sciences du Vivant, CEA, Orsay France
    J Neurochem 95:1521-40. 2005
    ..Research on 3NP provides additional proof that the neurochemical environment of a given neurone can determine its preferential vulnerability in neurodegenerative diseases...
  12. pmc Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1
    Meihua Luo
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Antioxid Redox Signal 10:1853-67. 2008
    ..Here we discuss small-molecule inhibition of Ape1 redox and its effect on both cancer and endothelial cells...
  13. pmc Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme
    Dian Su
    Department of Chemistry, Washington University in St Louis, St Louis, Missouri 63130, United States
    Biochemistry 50:82-92. 2011
    ..Collectively, our results suggest that APE1 adopts a partially unfolded state, which we propose is the redox active form of the enzyme...
  14. ncbi In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite
    Alejandro Betancor-Fernandez
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Germany
    Free Radic Res 36:915-21. 2002
    ..We conclude that alpha-CEHC is a molecule with good antioxidant activity, having the advantage over Trolox of being a naturally occurring compound. These properties might be useful for research or industrial purposes...
  15. ncbi Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats
    Klaus Peter Ossenkopp
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Canada
    Behav Brain Res 227:134-41. 2012
    ..During the extinction trials rats exhibited enhanced locomotor activity levels in the propionic acid associated chamber, likely due to the conditioned aversive nature of this chamber...
  16. pmc Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration
    Gang Ming Zou
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB 2, M341, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:2012-21. 2008
    ..Inhibition of the APE1 redox function through pharmacologic means has the potential to become a promising therapeutic strategy in this disease...
  17. ncbi Protective effect of rivastigmine against 3-nitropropionic acid-induced Huntington's disease like symptoms: possible behavioural, biochemical and cellular alterations
    Puneet Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 615:91-101. 2009
    ..The results show that rivastigmine could be used as an effective therapeutic agent in the management of Huntington's disease and related conditions...
  18. pmc Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae
    Vincent J Starai
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53726 4087, USA
    Genetics 163:545-55. 2003
    ..The data suggest that the Hst3 and Hst4 proteins are the most important for allowing growth on these short-chain fatty acids...
  19. ncbi AtABCG29 is a monolignol transporter involved in lignin biosynthesis
    Santiago Alejandro
    Institute of Plant Biology, University of Zurich, 8008 Zurich, Switzerland
    Curr Biol 22:1207-12. 2012
    ..This is the first identification of a monolignol transporter, closing a crucial gap in our understanding of lignin biosynthesis, which could open new directions for lignin engineering...
  20. ncbi Chromium(III) propionate complex supplementation improves carbohydrate metabolism in insulin-resistance rat model
    Ewelina Krol
    Department of Human Nutrition and Hygiene, University of Life Sciences, 31 Wojska Polskiego, 60 624 Poznan, Poland
    Food Chem Toxicol 48:2791-6. 2010
    ..Supplemental CrProp administered at 10- and 50-fold doses of the basal dietary Cr level has a significant antidiabetic effect in insulin resistant rats. However, a prolonged treatment with this compound can affect Fe status...
  21. ncbi N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington's disease
    Rajat Sandhir
    Department of Biochemistry, Panjab University, Chandigarh, India
    Neurodegener Dis 9:145-57. 2012
    ..NAC treatment, on the other hand, was found to be effective in reversing 3-NP-induced mitochondrial dysfunctions and neurobehavioral deficits. Our findings suggest a beneficial effect of NAC in HD...
  22. ncbi Antiproteinuric effect of chemokine C-C motif ligand 2 inhibition in subjects with acute proliferative lupus nephritis
    Alessandro Ble
    Angelini Research Center, Piazzale della Stazione, S Palomba, Pomezia, Italy
    Am J Nephrol 34:367-72. 2011
    ..To test the role of chemokine C-C motif ligand 2 (CCL2) in the pathogenesis of lupus nephritis (LN), we evaluated the effects of CCL2 inhibition by bindarit therapy in patients with systemic lupus and active renal disease...
  23. ncbi The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds
    G Lunardi
    Section of Pharmacology, Department of Oncology, Biology and Genetics, University of Genova, Genova, Italy
    Neuroscience 142:991-7. 2006
    ..CrOBzl and PCr-Mg-CPLX cross the plasma membrane in a transporter-independent way, and might be useful in the therapy of hereditary creatine transporter deficiency. They may also prove useful in the therapy of brain anoxia or ischemia...
  24. ncbi Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease
    Chiung Mei Chen
    Department of Neurology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 34:135-52. 2011
    ....
  25. pmc Bruchins: insect-derived plant regulators that stimulate neoplasm formation
    R P Doss
    Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330, USA
    Proc Natl Acad Sci U S A 97:6218-23. 2000
    ..5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants...
  26. pmc Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
    Ernesto J Muñoz-Elías
    Laboratory of Infection Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Nat Med 11:638-44. 2005
    ..tuberculosis on fatty acids and in macrophages. The absence of ICL orthologs in mammals should facilitate the development of glyoxylate cycle inhibitors as new drugs for the treatment of tuberculosis...
  27. ncbi Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism
    Sandy R Shultz
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Canada
    Behav Brain Res 200:33-41. 2009
    ..Neuropathological analysis from PPA-treated rats revealed an innate neuroinflammatory response. These findings add to evidence that PPA can change the brain and behavior in the laboratory rat consistent with symptoms of human autism...
  28. ncbi Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43
    Yeon Hee Hong
    Department of Food Production Science, Shinshu University, Nagano ken, Japan
    Endocrinology 146:5092-9. 2005
    ..We conclude that acetate and propionate short chain fatty acids may have important physiological roles in adipogenesis through GPCR43, but not through GPCR41...
  29. pmc Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo
    Jun Ming Wang
    Department of Pharmacology and Pharmaceutical Science, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 103:16983-8. 2006
    ..These data suggest that use of ER-selective ligands could provide therapeutic benefit to reduce the risk of AD by increasing ApoE expression in ApoE2/3 allele carriers and decreasing ApoE expression in ApoE4 allele carriers...
  30. ncbi Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro
    Dirleise Colle
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Brain Res Bull 87:397-405. 2012
    ..The toxic action of QA plus 3-NP seems to be involved with Ca2+ metabolism and ROS formation, and can be prevented or attenuated by antioxidant/scavenger compounds and NMDAr antagonists...
  31. ncbi Propionic acidemia: identification of twenty-four novel mutations in Europe and North America
    B Perez
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, CSIC UAM, Madrid, Spain
    Mol Genet Metab 78:59-67. 2003
    ....
  32. ncbi Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis
    Anna M Upton
    Laboratory of Infection Biology, The Rockefeller University, New York, NY 10021, USA
    Microbiology 153:3973-82. 2007
    ..These observations suggest that the marked attenuation of ICL1/ICL2-deficient M. tuberculosis in mice could be due to the accumulation of toxic propionyl-CoA metabolites, rather than inability to utilize fatty acids per se...
  33. ncbi Unexpectedly high prevalence of the mild form of propionic acidemia in Japan: presence of a common mutation and possible clinical implications
    Tohru Yorifuji
    Department of Pediatrics, Kyoto University Hospital, 54 Shogoin Sakyo, Kyoto 606 8507, Japan
    Hum Genet 111:161-5. 2002
    ..Taking into consideration previous findings regarding PCCB mutations, it appears that this gene is particularly prone to posttranscriptional modifications such as missense mediated exon skipping, mRNA decay, or rapid product degradation...
  34. ncbi Studies of propionate toxicity in Salmonella enterica identify 2-methylcitrate as a potent inhibitor of cell growth
    A R Horswill
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706 1567, USA
    J Biol Chem 276:19094-101. 2001
    ..This result lent further support to the in vivo data, which suggested that citrate synthase was the source of a toxic metabolite...
  35. ncbi Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons
    Donato Goffredo
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milano, Italy
    J Biol Chem 277:39594-8. 2002
    ..This cleavage could be prevented by calcium chelators and calpain inhibitors. Degradation of wild-type huntingtin by calcium-dependent proteases thus occurs in HD neurons, leading to loss of wild-type huntingtin neuroprotective activity...
  36. ncbi Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats
    Giovanni Cirillo
    Dipartimento di Medicina Pubblica Clinica e Preventiva, Seconda Universita di Napoli, Napoli, Italy
    Neurochem Int 56:152-60. 2010
    ..Therefore this model unveil the key role played by the different components of the tripartite synapse in the pathogenesis of the HD, a putative non-cell-autonomous disease...
  37. ncbi Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway
    K Gopinath
    Department of Biochemistry, Cell Biology Laboratory, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India
    Neuroscience 227:134-43. 2012
    ....
  38. ncbi A randomised phase II study of TSU-68 in patients with hepatocellular carcinoma treated by transarterial chemoembolisation
    Yoshitaka Inaba
    Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Japan
    Eur J Cancer 49:2832-40. 2013
    ..TSU-68 is an antitumour drug that acts by inhibiting angiogenesis. We evaluated the efficacy and safety of TSU-68 in combination with transarterial chemoembolisation (TACE) in patients with intermediate-stage hepatocellular carcinoma (HCC)...
  39. ncbi Application of Bruchin B to pea pods results in the up-regulation of CYP93C18, a putative isoflavone synthase gene, and an increase in the level of pisatin, an isoflavone phytoalexin
    L D Cooper
    Horticultural Crops Research Unit, USDA ARS, Corvallis, OR 97330, USA
    J Exp Bot 56:1229-37. 2005
    ..This, the first report of induction of phytoalexin biosynthesis by an insect elicitor, suggests that Bruchin B not only stimulates neoplasm formation, but also activates other plant defence responses...
  40. pmc In Salmonella enterica, 2-methylcitrate blocks gluconeogenesis
    Christopher J Rocco
    Department of Bacteriology, University of Wisconsin, 1550 Linden Dr, Madison, WI 53706 1521, USA
    J Bacteriol 192:771-8. 2010
    ..Our findings may help explain human inborn errors in propionate metabolism...
  41. ncbi Phase I clinical study of the angiogenesis inhibitor TSU-68 combined with carboplatin and paclitaxel in chemotherapy-naive patients with advanced non-small cell lung cancer
    Isamu Okamoto
    Department of Medical Oncology, Kinki University Faculty of Medicine, Osaka, Japan
    J Thorac Oncol 7:427-33. 2012
    ..An open-label, single-arm, phase I study was performed to evaluate escalating doses of TSU-68 in combination with standard chemotherapy in patients with advanced non-small cell lung cancer...
  42. ncbi p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum
    Xing Ding Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 5:339-50. 2009
    ..These results suggest that p53 plays roles in signaling both autophagy and apoptosis. Autophagy, at least partially, contributes to neurodegeneration induced by mitochondria dysfunction...
  43. pmc Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 980 W Walnut, Indianapolis, IN 46202, USA
    Exp Hematol 38:1178-88. 2010
    ....
  44. pmc The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders
    Raymond H Thomas
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, ON, N6A 5C2, Canada
    J Neuroinflammation 9:153. 2012
    ....
  45. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010
    ....
  46. ncbi Glutathione export from human erythrocytes and Plasmodium falciparum malaria parasites
    Margery A Barrand
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U K
    Biochem J 448:389-400. 2012
    ..These results are consistent with the view that the parasite supplies its host erythrocyte with GSH, much of which is exported from the infected cell via parasite-induced pathways...
  47. ncbi Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase
    Matthias Brock
    Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Marburg, Germany
    Eur J Biochem 269:6184-94. 2002
    ..This is in good agreement with investigations on Salmonella enterica LT2, in which disruption of the prpE gene showed no visible phenotype...
  48. pmc Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth
    Melissa L Fishel
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University of School of Medicine, 980 W Walnut, R3 548, Indianapolis, IN 46202, USA
    Mol Cancer Ther 10:1698-708. 2011
    ..These data indicate that E3330, inhibitor of APE1/Ref-1, has potential in pancreatic cancer and clinical investigation of APE1/Ref-1 molecular target is warranted...
  49. ncbi Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Arterioscler Thromb Vasc Biol 31:2448-54. 2011
    ..The aim of the current study was to evaluate the efficacy of bindarit on in-stent stenosis in the preclinical porcine coronary stent model...
  50. pmc The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1
    Nicola J Smith
    Molecular Pharmacology Group, Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 284:17527-39. 2009
    ....
  51. pmc Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models
    Dae Won Kim
    Department of Biomedical Sciences, College of Life Science, Hallym University, Chunchon Kangwon Do 200 702, Republic of Korea
    BMC Neurosci 11:141. 2010
    ....
  52. pmc Whole-genome transcription profiling reveals genes up-regulated by growth on fucose in the human gut bacterium "Roseburia inulinivorans"
    Karen P Scott
    Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    J Bacteriol 188:4340-9. 2006
    ..inulinivorans during growth on fucose. Despite the lack of genome sequence information for this commensal bacterium, microarray analysis has provided a powerful tool for obtaining new information on its metabolic capabilities...
  53. pmc Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice
    Yannis Hara
    UPMC Univ Paris 06, UMRS 956, Paris, France
    J Clin Invest 121:2888-97. 2011
    ..Our data suggest that MRP4 could represent a potential target for therapeutic intervention in PAH...
  54. ncbi Muscle-specific differences in the response of mitochondrial proteins to beta-GPA feeding: an evaluation of potential mechanisms
    Deon B Williams
    Alberta Diabetes Institute, 4126C HRIF East, Univ of Alberta, Edmonton, Alberta, Canada T6G 2E1
    Am J Physiol Endocrinol Metab 296:E1400-8. 2009
    ..The lack of an effect of beta-GPA feeding on mitochondrial proteins in the soleus muscles could be related to a fiber type-specific effect of beta-GPA on RIP140 protein content...
  55. pmc Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy
    Tuoping Luo
    Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    J Am Chem Soc 131:5667-74. 2009
    ..These pairing reactions include one based on a novel aza-Wittig-6pi-electrocyclization sequence and others based on ring-closing metathesis reactions...
  56. ncbi Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin
    A S Falcão
    Centro de Patogénese Molecular UBMBE, Faculdade de Farmacia, University of Lisbon, Avenida Professor Gama Pinto, 1649 003 Lisbon, Portugal
    Neuroscience 144:878-88. 2007
    ..These results point to a novel role of Mrp1 in the susceptibility of premature babies to UCB encephalopathy, and provide a startup point for the development of a new therapeutic strategy...
  57. ncbi Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids
    Mohamed S Zaibi
    Clore Laboratory, University of Buckingham, Buckingham, UK
    FEBS Lett 584:2381-6. 2010
    ..Pertussis toxin prevented stimulation of leptin secretion by propionate in epididymal adipocytes, implicating Galpha(i) signalling mediated by GPR43 in SCFA-stimulated leptin secretion...
  58. pmc Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins
    Marina A Schwab
    Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children s Hospital Heidelberg, Im Neuenheimer Feld 150, D 69120 Heidelberg, Germany
    Biochem J 398:107-12. 2006
    ....
  59. ncbi Insecticidal, acaricidal and repellent effects of DEET- and IR3535-impregnated bed nets using a novel long-lasting polymer-coating technique
    Michael K Faulde
    Department of Medical Entomology Zoology, Central Institute of the Bundeswehr Armed Forces Medical Service, Koblenz, Germany
    Parasitol Res 106:957-65. 2010
    ..First results on bioactivity and long-lasting efficacy show that the new LLRTN technique is highly promising as a potential candidate for future malaria control strategies, especially in areas where pyrethroid resistance occurs...
  60. ncbi Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain
    Puneet Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 33:100-8. 2009
    ..The present study suggests the possible antioxidant role of sertraline against 3-nitropropionic acid induced alterations in animals...
  61. ncbi Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
    Gang Ming Zou
    Department of Pediatrics Section of Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1917-22. 2007
    ..In summary, these data indicate Ape1 is required in normal embryonic hematopoiesis and that the redox function, but not the repair endonuclease activity, of Ape1 is critical in normal embryonic hematopoietic development...
  62. ncbi Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism
    Karine M Egan
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 111:334-42. 2005
    ..We addressed this issue and the role of TxA2 in the promotion and regression of diffuse, established atherosclerosis in Apobec-1/LDLR double KOs (DKOs)...
  63. ncbi Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine
    Ernest Boehm
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Am J Physiol Endocrinol Metab 284:E399-406. 2003
    ..We conclude that, in heart, creatine transport is determined by the content of a plasma membrane isoform of the CrT but not by the total cellular CrT pool...
  64. ncbi Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    P Klivenyi
    Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Neurosci 20:1-7. 2000
    ....
  65. ncbi Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins
    Nestor E Rulli
    Faculty of Applied Science, University of Canberra, Canberra, ACT, Australia
    Arthritis Rheum 60:2513-23. 2009
    ..The aim of the present investigations was to determine whether bindarit, an inhibitor of monocyte chemotactic protein (MCP) synthesis, could ameliorate alphavirus-induced rheumatic disease in mice...
  66. ncbi On the mechanism of action of the antifungal agent propionate
    Matthias Brock
    Laboratorium für Mikrobiologie, Universitat Hannover, Germany
    Eur J Biochem 271:3227-41. 2004
    ..A possible toxicity of propionyl-CoA for humans in diseases such as propionic acidaemia and methylmalonic aciduria is also discussed...
  67. ncbi Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid
    Gyung W Kim
    Department of Neurosurgery, Stanford University School of Medicine, California 94305 5487, USA
    J Cereb Blood Flow Metab 22:798-809. 2002
    ..001). These data suggest that production of superoxide may be a critical step to excitotoxicity and subsequent DNA fragmentation in selective striatal vulnerability after 3-NP treatment...
  68. pmc RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists
    Keith R Bley
    Roche Palo Alto, Palo Alto, CA 94304, USA
    Br J Pharmacol 147:335-45. 2006
    ..These data suggest that RO1138452 and RO3244794 are potent and selective antagonists for both human and rat IP receptors and that they possess analgesic and anti-inflammatory potential...
  69. pmc Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1
    Mark R Kelley
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 980 West Walnut Street, Indianapolis, IN 46202, USA
    Antioxid Redox Signal 14:1387-401. 2011
    ..This progress in synthesizing and isolating biologically active novel E3330 analogues that effectively inhibit the APE1 redox function validates the utility of further translational anticancer therapeutic development...
  70. pmc Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death
    Y Tang
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine and Simmons Cancer Institute, Springfield, IL 62794, USA
    Cell Death Differ 18:602-18. 2011
    ....
  71. ncbi Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia
    Nga H T Nguyen
    Norwegian Defence Research Establishment, Kjeller, Norway
    J Neurochem 101:806-14. 2007
    ..Propionic acidemia may alter both neuronal and glial gene expression by affecting histone acetylation...
  72. ncbi Treatment of pea pods with Bruchin B results in up-regulation of a gene similar to MtN19
    Robert P Doss
    Horticultural Crops Research Unit, Agricultural Research Service, United States Department of Agriculture, 3420 N W Orchard Avenue, Corvallis, OR 97330, USA
    Plant Physiol Biochem 43:225-31. 2005
    ..Given the rapid and strong up-regulation after exposure of pods to a bruchin, it is likely that this gene plays an important role in the response of pea to these insect elicitors...
  73. pmc Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway
    Eugenio Mora
    Center for Epigenetics and Metabolism, School of Medicine, University of California at Irvine, Irvine, CA, USA
    Cell Cycle 11:159-69. 2012
    ..These findings pave the way for future applications of bindarit as modulator of the inflammatory response...
  74. ncbi A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma
    Fumihiko Kanai
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Cancer Chemother Pharmacol 67:315-24. 2011
    ....
  75. pmc The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice
    Gianluca Grassia
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Naples, Italy
    Cardiovasc Res 84:485-93. 2009
    ....
  76. ncbi Evaluation of anti-diabetic potential of chromium(III) propionate complex in high-fat diet fed and STZ injected rats
    Ewelina Krol
    Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Wojska Polskiego 31, 60 624 Poznan, Poland
    Food Chem Toxicol 49:3217-23. 2011
    ..In conclusion, CrProp has a significant anti-diabetic (insulin-sensitizing and hypolipidemic) potential; thus it might be a candidate for a therapeutic agent in diabetes...
  77. pmc HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease
    Zoya Niatsetskaya
    Burke Cornell Medical Research Institute, White Plains, New York 10605, USA
    Antioxid Redox Signal 12:435-43. 2010
    ....
  78. ncbi Succinobucol versus probucol: higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro
    Dirleise Colle
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Mitochondrion 13:125-33. 2013
    ..The present findings suggest that succinobucol might be a novel strategy to slow or halt oxidative events in neurodegenerative conditions...
  79. ncbi Formation of propionate after short-term ethanol treatment and its interaction with the carnitine pool in rat
    V Calabrese
    Biochemistry, Faculty of Medicine, University of Catania, Italy
    Alcohol 19:169-76. 1999
    ..This study suggests that endogenous carnitine pool might play a role against the deleterious effects of accumulating short-chain organic acids...
  80. ncbi Intracellular pH modulates spontaneous and epileptiform bioelectric activity of hippocampal CA3-neurones
    U Bonnet
    Rheinische Kliniken, Universitatsklinik fur Psychiatrie und Psychotherapie, POB 103043, D 45030, Essen, Germany
    Eur Neuropsychopharmacol 10:97-103. 2000
    ..Together, these results indicate that intracellular acidification inhibits bioelectric activity of hippocampal CA3-neurones. This supports the hypothesis that pH(i) contributes to the control of cortical excitability...
  81. ncbi Green and economical production of propionic acid by Propionibacterium freudenreichii CCTCC M207015 in plant fibrous-bed bioreactor
    Xiaohai Feng
    State Key Laboratory of Materials Oriented Chemical Engineering, Nanjing 210009, PR China
    Bioresour Technol 102:6141-6. 2011
    ..81 ± 3.99 g l(-1) at 302 h. The present study suggests that the low-cost molasses and waste propionibacterium cells can be utilized for the green and economical production of propionic acid by P. freudenreichii...
  82. ncbi Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1
    F Bautz
    Department of Medicine II, , , Germany
    Blood 97:3433-40. 2001
    ..This would be a first physiologic effect of cysteinyl leukotrienes apart from the many known pathophysiologic actions related to allergy and inflammation. (Blood. 2001;97:3433-3440)..
  83. ncbi Construction and characterization of ack knock-out mutants of Propionibacterium acidipropionici for enhanced propionic acid fermentation
    Supaporn Suwannakham
    Department of Chemical and Biomolecular Engineering, The Ohio State University, 140 West 19th Avenue, Columbus, Ohio 43210, USA
    Biotechnol Bioeng 94:383-95. 2006
    ..Both mutants produced approximately 14% less acetate from glucose. Although ack disruption alone did not completely eliminate acetate production, the propionate yield was increased by approximately 13%...
  84. ncbi Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction
    M Horn
    Medizinische Universitatsklinik, Wurzburg University, Germany
    Circulation 104:1844-9. 2001
    ..In the present study, myocardial PCr stores in a heart failure model were further depleted by feeding of the PCr analogue beta-guanidinopropionate (GP). Functional and metabolic consequences were studied...
  85. ncbi Stimulation of HSP72 expression following ATP depletion and short-term exercise training in fast-twitch muscle
    L Ecochard
    Unite Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Physiologie, Universite Claude Bernard, Lyon, France
    Acta Physiol Scand 180:71-8. 2004
    ..In this study, we tested the hypothesis that energy status is a key regulatory event for HSP72 accumulation in skeletal muscles...
  86. ncbi Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys
    M D Meglasson
    Metabolic Diseases Research, Upjohn Company, Kalamazoo, Michigan
    J Pharmacol Exp Ther 266:1454-62. 1993
    ..Because acidic derivatives uniquely lack the propensity of guanidine compounds for inducing lactic acidosis, our finding suggests a new approach for developing improved antidiabetes compounds from this chemical class...
  87. ncbi Interaction of carnitine and propionate with pyruvate oxidation by hepatocytes from clofibrate-treated rats: importance of coenzyme A availability
    E P Brass
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106
    J Nutr 122:234-40. 1992
    ..Metabolic toxicity of propionate is the result of both the increased cellular propionyl-CoA content and the depletion of cellular unesterified CoA...
  88. ncbi Decreasing intramuscular phosphagen content simultaneously increases plasma membrane FAT/CD36 and GLUT4 transporter abundance
    Kristin E Pandke
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 295:R806-13. 2008
    ..Thus the content of sarcolemmal transporters for both of the major energy substrates for muscle increased in response to a reduced energy charge. Increased phosphorylation of AMPK may be one of the triggers for this response...
  89. ncbi Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis
    M Bhatia
    Cardiovascular Biology Group, Department of Pharmacology, c o Centre for Life Science, 03 02 National University of Singapore, 28 Medical Dr, Singapore 117456, Malaysia
    Inflamm Res 57:464-71. 2008
    ....
  90. pmc Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice
    K L Gabrielson
    Division of Comparative Medicine, School of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Am J Pathol 159:1507-20. 2001
    ....
  91. pmc Anti-inflammatory activity of creatine supplementation in endothelial cells in vitro
    Akihiro Nomura
    Department of Pulmonary Medicine, Institute of Clinical Medicine, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Br J Pharmacol 139:715-20. 2003
    ..7 The present study suggests that CR supplementation has anti-inflammatory activities against endothelial cells...
  92. ncbi Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways
    Michiko Aoyama
    Division of Nutrition and Metabolism, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan
    Nutrition 26:653-61. 2010
    ..We investigated the effects of SCFAs on apoptosis of activated and non-activated neutrophils and their mechanisms...
  93. ncbi Efflux of glutathione and glutathione complexes from human erythrocytes in response to vanadate
    Yeliz Cakir
    Mustafa Kemal University, Faculty of Arts and Science, Biology Department, Antakya, Turkey
    Blood Cells Mol Dis 50:1-7. 2013
    ..The results of the present study indicate that human erythrocyte efflux glutathione in reduced free form and in conjugated form/s that can be recovered with dimercaptosuccinic acid when exposed to vanadate...
  94. ncbi Effects of the creatine analogue beta-guanidinopropionic acid on skeletal muscles of mice deficient in muscle creatine kinase
    J van Deursen
    Department of Cell Biology and Histology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands
    Biochim Biophys Acta 1185:327-35. 1994
    ..Altogether, these results provide evidence that certain functions of the creatine kinase/phosphocreatine (CK/PCr) system are not eliminated solely by the loss of M-CK...
  95. ncbi Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity
    M A Hickey
    Department of Pharmacology, University of Cambridge, Cambridge, England
    J Neurochem 75:2163-71. 2000
    ..The existence of similar compensatory mechanisms may explain why, in humans, HD is a late-onset disorder, despite early expression of the genetic mutation...
  96. pmc Differential effects of endurance training and creatine depletion on regional mitochondrial adaptations in rat skeletal muscle
    D Roussel
    Laboratoire de Physiologie des Régulations Energétiques, Cellulaires et Moleculaires, UMR 5578 CNRS, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Biochem J 350:547-53. 2000
    ..It therefore seems that endurance training and feeding with GPA, which are both known to alter the energetic status of the muscle cell, might mediate distinct biochemical adaptations in regional skeletal muscle mitochondria...
  97. ncbi Depressive-like behavior in mice recently recovered from motor disorders after 3-nitropropionic acid intoxication
    Xiao min Li
    Department of Physiology, Tongji University School of Medicine, Shanghai, China
    Neurosci Bull 24:225-30. 2008
    ..In the present study, we have investigated the depressive-like behavior in mice recently intoxicated with 3-nitropropionic acid (3-NP), a widely known toxin that selectively damages the striatum in the brain...
  98. pmc GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function
    Tamas L Horvath
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Neurobiol Dis 43:152-62. 2011
    ..Mitochondrial dysfunction is a common problem in neurodegeneration and thus GPA may slow disease progression in other models of neurodegeneration...
  99. ncbi SCF-induced airway hyperreactivity is dependent on leukotriene production
    S H Oliveira
    Department of Pathology, University of Michigan Medical School, 13012 Catherine, Ann Arbor, MI 48109-0602, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1242-9. 2001
    ..Altogether, these studies indicate that SCF-induced airway hyperreactivity is dependent upon leukotriene-mediated pathways...
  100. ncbi Evaluation and comparison of MRP1 activity with three fluorescent dyes and three modulators in leukemic cell lines
    A Lale Dogan
    Laboratoire INSERM E03 55 EA 1529, Département d Onco Hématologie, Hôpital Hotel Dieu AP HP, Universite Paris 6, 1 Place du Parvis Notre Dame, Paris 75004, France
    Leuk Res 28:619-22. 2004
    ..In conclusion, calcein-AM and CFDA uptake assays are the best choices to probe MRP1 activity and combination of two modulators may improve the efficiency of these assays...
  101. ncbi Zeolite framework stabilized copper complex inspired by the 2-His-1-carboxylate facial triad motif yielding oxidation catalysts
    Kaisa Kervinen
    Department of Inorganic Chemistry and Catalysis, Utrecht University, Debye Institute, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Am Chem Soc 128:3208-17. 2006
    ..It was therefore found that encapsulation in zeolite offers a route to stabilize a 5-fold-coordinated copper complex with novel catalytic properties. This 1:1 Cu(MIm2Pr) complex is not formed in solution...

Research Grants65

  1. CYTOCHROME B5--A CASE STUDY IN MOLECULAR RECOGNITION
    Mario Rivera; Fiscal Year: 1999
    ..II. Elucidate the role that heme propionates in cytochrome b5 play in binding to physiological partner proteins such as cytochromes c and P-450...
  2. QM/MM analysis of redox driven proton pumping
    Qiang Cui; Fiscal Year: 2010
    ..to help identify the most likely candidate(s) for the loading site of pumped protons among His334 and the propionates of the heme co-factor. (ii)...
  3. PEROXYCARBENIUM BASED SYNTHESIS IN NATURAL PRODUCTS
    Patrick Dussault; Fiscal Year: 2001
    ..natural products: hydroperoxyeicosatetraenoic acids (HPETEs), alkoxydioxines, and 1,2-dioxane propionates. He reports that produced in man through dioxygenation of arachidonic acid, HPETES are involved in many aspects ..
  4. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  5. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..Effective treatment of nausea may substantially improve the quality of life for patients with chronic disease. ..
  6. Chemosensitization of Pancreatic Tumors via Inhibition of a DNA BER Enzyme, Ape1
    Melissa Fishel; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  8. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  9. ONTOGENY OF METABOLIC CONTROLS OF INGESTIVE BEHAVIOR
    SUSAN SWITHERS; Fiscal Year: 2002
    ..Finally, the neural mechanisms involved in translating physiological changes related to energy utilization into increases in ingestive behavior are tested. ..
  10. CONTROL OF FEEDING BEHAVIOR--HEPATIC AFFERENT SIGNALING
    CHARLES HORN; Fiscal Year: 2002
    ..Results from this project may contribute to a better understanding of metabolic stimuli that are sensed by the nervous system, and may elucidate neural controls that are involved in obesity, anorexia, and diabetes. ..
  11. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005
    ..Laulimalide stimulates tubulin polymerization more effectively than paclitaxel. Laulimalide is a representative of a new class of microtubule stabilizing agents with promise for therapeutic potential. ..
  12. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  13. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
    ..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
  14. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2007
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  15. Bioenergetics in Animal Models of Huntington's Disease
    M Beal; Fiscal Year: 2007
    ..We will, therefore, examine whether a combination of creatine or coenzyme Q with either a HDAC inhibitor or a phosphodiesterase IV inhibitor can exert additive neuroprotective effects. [unreadable] [unreadable]..
  16. Perinatal hypoxia-ischemia, glutamate receptors, and Nitric Oxide Synthase
    Zhengwei Cai; Fiscal Year: 2007
    ..Direct effects of inflammatory cytokines and IGF-1 on survival and differentiation of OLs will be examined in cultures of OLs at various maturation stages. ..
  17. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  18. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  19. Antioxidant Approaches to Alzheimer's Disease Therapy
    M Beal; Fiscal Year: 2007
    ..If we can demonstrate significant effects of CoQ10 and L-NIL, this could lead to rapid development of new therapies for slowing the progression of AD. [unreadable] [unreadable]..
  20. Initiation of Multidrug Transport at Fertilization.
    Amro Hamdoun; Fiscal Year: 2007
    ..abstract_text> ..
  21. CYTOMIMETIC ORGANIC CHEMISTRY
    FREDRIC MENGER; Fiscal Year: 2007
    ....
  22. F-18 Synthesizer
    Anna Liisa Brownell; Fiscal Year: 2007
    ..The synthesizer must balance a number of factors in the design to fulfill requirements for performance, accessibility and fitness to the research environment. [unreadable] [unreadable] [unreadable]..
  23. Combination Drug Therapy in Huntington's Disease
    ROBERT FERRANTE; Fiscal Year: 2008
    ..abstract_text> ..
  24. Commensals and Probiotics: Role in Intestinal Physiology
    Silvia Resta Lenert; Fiscal Year: 2008
    ....
  25. Interactions for Pesticides, mitochondria and genetics in Parkinson's disease.
    M Flint Beal; Fiscal Year: 2010
    ..The study will enrich and refine our understanding of pesticide-induced cell damage pathways observed in sporadic and familial PD and identify new target(s) for intervention in PD pathogenesis. ..
  26. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  27. The Role of the KLF2 in Vascular Endothelial Cells
    Jerry B Lingrel; Fiscal Year: 2010
    ..Importantly, they will serve as a prerequisite for further investigation of KLF2 as a vaso-protective therapeutic target. ..
  28. Training Program in Molecular and Cellular Toxicology
    John Reiners; Fiscal Year: 2008
    ..It is envisioned that students with such training will be better equipped to pursue postdoctoral research at major research laboratories throughout the United States. ..
  29. Metabolomic and Isotopomer Analysis of Xenobiotic Stress
    Henri Brunengraber; Fiscal Year: 2009
    ..This will be achieved by administering low doses of 2H20 and acetaminophen, followed by measuring the 2H-labeling of urinary acetaminophen-glutathione adduct. ..
  30. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  31. Olfaction as a Biomarker for Parkinson's Disease
    Anna Liisa Brownell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. CysLt and P2Y Receptors and Lung Inflammation
    Joshua Boyce; Fiscal Year: 2007
    ..abstract_text> ..
  33. A role for circadian clock genes in hippocampal function?
    Christopher Colwell; Fiscal Year: 2008
    ..This line of research has not been previously funded, is exploratory in nature, and thus qualifies under the R21 format. [unreadable] [unreadable] [unreadable]..
  34. Reconstruction of nigrostriatal pathway by photopolymerized neurotrophin...
    Kimberly Bjugstad; Fiscal Year: 2008
    ..While we are using an animal model of PD to test this hypothesis, if successful, it could have implications for other neurodegenerative disorders, including Huntington's Disease or stroke. [unreadable] [unreadable] [unreadable]..
  35. Development of NET-Selective Piperidine-Based PET Ligand
    Anna Liisa Brownell; Fiscal Year: 2006
    ..4. Promising PET imaging agents will be studied in cell toxicity and animal models during the second year. ..
  36. Propeptide-Mediated Protein Folding
    Masayori Inouye; Fiscal Year: 2006
    ..Another emphasis is to investigate how the nascent folding intermediate can be activated with small peptide substrates. ..
  37. Novel Approaches for in vivo of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2006
    ..abstract_text> ..
  38. INVESTIGATIONS ON GLUCONEOGENESIS
    Henri Brunengraber; Fiscal Year: 2003
    ..We hope that the data of our investigations will help to devise new strategies for improving the treatment of type I diabetic patients. ..
  39. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  40. OXIDATIVE DNA DAMAGE AND REPAIR IN CNS CELLS
    Mark Kelley; Fiscal Year: 2003
    ..abstract_text> ..
  41. STRESS RESPONSE AND ADAPTATION IN ESCHERICHIA COLI
    Masayori Inouye; Fiscal Year: 2003
    ..The proposed research will provide important insight into the fundamental principles of stress response and adaptation in prokaryotes. ..
  42. GC Continuous Flow Isotope Ratio Mass Spectrometer
    Henri Brunengraber; Fiscal Year: 2003
    ..The costs of operating and maintaining the instrument will be shared by the users. The availability of this instrument will considerably increase the scope of the basic science and clinical investigations conducted by the applicants. ..
  43. PH REGULATION IN VENTRICULAR CELLS
    KENNETH SPITZER; Fiscal Year: 2002
    ..The results of this project will yield new information concerning hormonal modulation of cardiac pHi control systems and the action of intracellular and intercellular H+ diffusion to dissipate regional pHi gradients. ..
  44. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  45. OLFACTORY FUNCTION IN GENE-TARGETED MICE
    Burton Slotnick; Fiscal Year: 2002
    ..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
  46. AUTONOMIC REGULATION OF AIRWAY SMOOTH MUSCLE TONE
    BRENDAN CANNING; Fiscal Year: 2001
    ..It is anticipated that this information will improve our understanding of the role of the autonomic innervation of the healthy and diseased lung. ..
  47. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  48. OLFACTORY CODING
    Burton Slotnick; Fiscal Year: 2003
    ..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
  49. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  50. The Role of Mast Cells in Lung Inflammation
    Joshua Boyce; Fiscal Year: 2006
    ..These studies, carried out in non-transformed hPrMC and hMC, have potential implications for the control of hMC distribution and effector function in asthma. ..
  51. HEPATIC MECHANISM FOR CONTROL OF FOOD INTAKE
    Mark Friedman; Fiscal Year: 2003
    ..To address this, an experiment will be performed to determine whether a metabolic hunger signal originates from hepatocytes. ..
  52. Retinal Inputs to the Mammalian Circadian Pacemaker
    KWOON WONG; Fiscal Year: 2006
    ..These experiments may enable a better understanding of how the mammalian circadian pacemaker is regulated, which in turn may lead to better therapies and workplace policies combating/preventing jet lag problems. ..
  53. Apoptotic and Necrotic Death of OHCs in NIHL
    Bo Hua Hu; Fiscal Year: 2006
    ..The knowledge of the biological mechanisms responsible for modulation of the cell death pathways will provide the basis for eventually developing a rational protective strategy. ..
  54. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    JANICE WAGNER; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  55. MICROPET FOR ANIMAL STUDIES
    Anna Liisa Brownell; Fiscal Year: 2001
    ..Our previous experience in developing and operating PET systems will be of great benefit in the expansion of the facility. ..
  56. METABOLIC CONTROL OF FEEDING BEHAVIOR
    Mark Friedman; Fiscal Year: 2005
    ..2) Determine whether overeating in obesity prone rats is due to a slow restoration of liver energy status. (3) Determine whether calcium signaling during metabolic stimulus transduction differs in hepatocytes from lean and obese rats. ..
  57. Studies of the Lung Kruppel-Like Transcription Factor
    Jerry Lingrel; Fiscal Year: 2004
    ..We will use gene microarray analysis of cells with and without the LKLF gene and develop conditional expression of LKLF to define downstream target genes in tissues such as lung, macrophages and T-lymphocytes. ..
  58. Dopamine Toxicity in Models of Huntington's Disease
    William Maragos; Fiscal Year: 2004
    ..The results of these studies will demonstrate the critical role that metabolism of dopamine plays in striatal neuron death in Huntington's disease and offer a potentially novel therapeutic approach for the treatment of this disorder. ..
  59. Cold Shock Vectors for Single Protein Production
    Masayori Inouye; Fiscal Year: 2004
    ..The proposed vector-host system will be highly useful not only for structural biology but also for medicinal research involving human proteins, which can not be obtained by conventional expression systems. ..
  60. ROLE OF NITRIC OXIDE IN FERTILIZATION
    David Epel; Fiscal Year: 2002
    ..The possible role of NO in regulating the egg's ion channels (as part of polyspermy block) and sperm physiology (such as motility and the acrosome reaction) will also be investigated. ..
  61. Temporal Integration in Nasal Lateralization
    Paul Wise; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. MRP/GST Synergy in MDR
    Charles Morrow; Fiscal Year: 2009
    ..abstract_text> ..
  63. Summer Institute Preparation for Careers in Microbiology
    JORGE ESCALANTE; Fiscal Year: 2002
    ..The Institute is the first and only program of its kind providing students with hands-on, practical training in communications and teaching, ethics, grant preparation and review. ..
  64. B12 Biosysthesis and Anaerobic Metabolism in Salmonella
    JORGE ESCALANTE; Fiscal Year: 2009
    ..Lastly, we will begin to dissect the biosynthetic pathways for the lower ligand base. One pathway is largely non-enzymatic while the other one is a piecemeal pathway. ..