fumarates

Summary

Top Publications

  1. ncbi Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis
    Steven G Chrysant
    University of Oklahoma, Oklahoma City, OK 73132, USA
    Curr Med Res Opin 24:1039-47. 2008
  2. ncbi Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
    Ralf A Linker
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, D 44791 Bochum, Germany
    Brain 134:678-92. 2011
  3. ncbi Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway
    Robert H Scannevin
    Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Pharmacol Exp Ther 341:274-84. 2012
  4. ncbi HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability
    Jennifer S Isaacs
    Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Cell 8:143-53. 2005
  5. pmc Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling
    Chang Joo Oh
    Department of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    PLoS ONE 7:e45870. 2012
  6. ncbi Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis
    Ralf Gold
    Department of Neurology, St Josef Hospital Ruhr University Bochum, Bochum, Germany
    N Engl J Med 367:1098-107. 2012
  7. pmc Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling
    Haiyan Peng
    Neuroscience Graduate Studies Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 287:28017-26. 2012
  8. ncbi Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
    Robert J Fox
    Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH 44195, USA
    N Engl J Med 367:1087-97. 2012
  9. pmc Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
    Kamran Ghoreschi
    Department of Dermatology, University Medical Center and 2 Interfaculty Institute for Biochemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    J Exp Med 208:2291-303. 2011
  10. ncbi Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 119:530-7. 2009

Detail Information

Publications274 found, 100 shown here

  1. ncbi Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis
    Steven G Chrysant
    University of Oklahoma, Oklahoma City, OK 73132, USA
    Curr Med Res Opin 24:1039-47. 2008
    ..Here we report the results of a pre-planned 6-month interim analysis of a long-term, open-label study examining the safety, tolerability and efficacy of the aliskiren/valsartan 300/320-mg combination in patients with hypertension...
  2. ncbi Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
    Ralf A Linker
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, D 44791 Bochum, Germany
    Brain 134:678-92. 2011
    ..In vitro, the application of fumarates increased murine neuronal survival and protected human or rodent astrocytes against oxidative stress...
  3. ncbi Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway
    Robert H Scannevin
    Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Pharmacol Exp Ther 341:274-84. 2012
    ..The clinical utility of DMF in multiple sclerosis is being explored through phase III trials with BG-12, which is an oral therapeutic containing DMF as the active ingredient...
  4. ncbi HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability
    Jennifer S Isaacs
    Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Cell 8:143-53. 2005
    ..Further, we show that fumarate acts as a competitive inhibitor of HPH. These data delineate a novel fumarate-dependent pathway for regulating HPH activity and HIF protein levels...
  5. pmc Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling
    Chang Joo Oh
    Department of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    PLoS ONE 7:e45870. 2012
    ..In summary, DMF attenuated renal fibrosis via the Nrf2-mediated inhibition of TGF-β/Smad3 signaling in an ARE-independent manner, suggesting that DMF could be used to treat renal fibrosis...
  6. ncbi Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis
    Ralf Gold
    Department of Neurology, St Josef Hospital Ruhr University Bochum, Bochum, Germany
    N Engl J Med 367:1098-107. 2012
    ....
  7. pmc Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling
    Haiyan Peng
    Neuroscience Graduate Studies Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 287:28017-26. 2012
    ..Taken together, these studies indicate that by suppression of both NF-κB and ERK1/2-MSK1 signaling, DMF inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation...
  8. ncbi Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
    Robert J Fox
    Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH 44195, USA
    N Engl J Med 367:1087-97. 2012
    ..BG-12 (dimethyl fumarate) is in development as an oral treatment for relapsing-remitting multiple sclerosis, which is commonly treated with parenteral agents (interferon or glatiramer acetate)...
  9. pmc Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
    Kamran Ghoreschi
    Department of Dermatology, University Medical Center and 2 Interfaculty Institute for Biochemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    J Exp Med 208:2291-303. 2011
    b>Fumarates improve multiple sclerosis (MS) and psoriasis, two diseases in which both IL-12 and IL-23 promote pathogenic T helper (Th) cell differentiation. However, both diseases show opposing responses to most established therapies...
  10. ncbi Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 119:530-7. 2009
    ..We compared the effect of aliskiren, the first orally active direct renin inhibitor, the angiotensin-receptor blocker losartan, and their combination on the reduction of LV mass in hypertensive patients...
  11. ncbi Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes
    Y F Dong
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    Diabetologia 53:180-91. 2010
    ..The present study was undertaken to examine the efficacy of aliskiren, a direct renin inhibitor, on cardiovascular injuries, glucose intolerance and pancreatic injury in a mouse model of type 2 diabetes...
  12. pmc Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease
    Gisa Ellrichmann
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 6:e16172. 2011
    ..In conclusion, DMF may exert beneficial effects in mouse models of HD. Given its excellent side effect profile, further studies with DMF as new therapeutic approach in HD and other neurodegenerative diseases are warranted...
  13. pmc Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling
    Julie Adam
    Nuffield Department of Medicine, Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, UK
    Cancer Cell 20:524-37. 2011
    ....
  14. ncbi Structure-based design of aliskiren, a novel orally effective renin inhibitor
    Jeanette M Wood
    Novartis Institute for Biomedical Research, Klybeckstrasse 220, CH 4002 Basel, Switzerland
    Biochem Biophys Res Commun 308:698-705. 2003
    ..Aliskiren represents the first in a novel class of renin inhibitors with the potential for treatment of hypertension and related cardiovascular diseases...
  15. pmc Cloning and sequence of cymA, a gene encoding a tetraheme cytochrome c required for reduction of iron(III), fumarate, and nitrate by Shewanella putrefaciens MR-1
    C R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Bacteriol 179:1143-52. 1997
    ..The localization of the fumarate and iron(III) reductases to the periplasm and outer membrane of MR-1, respectively, suggests the possibility of a similar electron transfer role for CymA...
  16. ncbi Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats
    David L Feldman
    Novartis Institutes for BioMedical Research, Bldg 437, Rm 3317, One Health Plaza, E Hanover, NJ 07936, USA
    Hypertension 52:130-6. 2008
    ....
  17. ncbi Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression
    B Gesser
    Department of Dermatology, Aarhus University Hospital, P P Oerumsgade 11, 8000 Aarhus, Denmark
    Inflamm Res 60:643-53. 2011
    ....
  18. ncbi Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats
    Joep H M van Esch
    Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    J Hypertens 28:2145-55. 2010
    ..Here, we compared the cardiac effects of aliskiren, the AT1 receptor blocker irbesartan and the ACE inhibitor captopril in spontaneously hypertensive rats (SHR) at equi-hypotensive doses...
  19. ncbi Aliskiren reduces sympathetic nerve activity and blood pressure in chronic kidney disease patients
    Laima Siddiqi
    Department of Nephrology and Hypertension, University Medical Centre Utrecht, Utrecht, The Netherlands
    Nephrol Dial Transplant 26:2930-4. 2011
    ..Hypertensive chronic kidney disease (CKD) patients often have sympathetic hyperactivity. In this pilot study, we evaluated the effect of 6 weeks treatment with aliskiren on sympathetic activity in hypertensive Stages 2-4 CKD patients...
  20. pmc Anode biofilm transcriptomics reveals outer surface components essential for high density current production in Geobacter sulfurreducens fuel cells
    Kelly P Nevin
    Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, USA
    PLoS ONE 4:e5628. 2009
    ..sulfurreducens biofilms to electrodes...
  21. ncbi Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production
    Vivek P Singh
    Cardiovascular Research Institute, Texas A and M HSC, Temple, TX 76504, USA
    Am J Physiol Heart Circ Physiol 294:H1675-84. 2008
    ....
  22. ncbi Dimethyl fumarate - only an anti-psoriatic medication?
    Markus Meissner
    Department of Dermatology, Venereology and Allergology, University of Frankfurt, Germany
    J Dtsch Dermatol Ges 10:793-801. 2012
    ..This valued and well-known drug mainly prescribed by dermatologists is now experiencing a renaissance far beyond dermatologic applications...
  23. ncbi Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1
    Joachim C U Lehmann
    CRBA Inflammation, Schering AG, Berlin, Germany
    J Invest Dermatol 127:835-45. 2007
    ....
  24. ncbi Baseline characteristics in the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE)
    Hans Henrik Parving
    Department of Medical Endocrinology, Rigshospitalet, University of Copenhagen, Denmark
    J Renin Angiotensin Aldosterone Syst 13:387-93. 2012
    ..Aliskiren, a novel direct renin inhibitor, which lowers plasma renin activity, may thereby provide greater cardio-renal protection compared with angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) alone...
  25. ncbi Patients with acute coronary syndromes and elevated levels of natriuretic peptides: the results of the AVANT GARDE-TIMI 43 Trial
    Benjamin M Scirica
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 31:1993-2005. 2010
    ....
  26. pmc Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes
    Matthew Blatnik
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA
    Ann N Y Acad Sci 1126:272-5. 2008
    ....
  27. ncbi Amino acid-dependent growth of Campylobacter jejuni: key roles for aspartase (AspA) under microaerobic and oxygen-limited conditions and identification of AspB (Cj0762), essential for growth on glutamate
    Edward Guccione
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mol Microbiol 69:77-93. 2008
    ..Together, our data highlight the dual function of aspartase in C. jejuni and suggest a role during growth in the avian gut...
  28. ncbi Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
    Eur Heart J 32:1227-34. 2011
    ....
  29. ncbi Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B/p65 in human endothelial cells
    Robert Loewe
    Department of Dermatology, Division of General Dermatology, University of Vienna Medical School, Vienna, Austria
    J Immunol 168:4781-7. 2002
    ..Moreover, DMF does not block NF-kappa B/DNA binding. In conclusion, DMF appears to selectively prevent the nuclear entry of activated NF-kappa B, and this may be the basis of its beneficial effect in psoriasis...
  30. pmc Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response
    Ohad Yogev
    Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    PLoS Biol 8:e1000328. 2010
    ..This study shows an exciting crosstalk between primary metabolism and the DNA damage response, thereby providing a scenario for metabolic control of tumor propagation...
  31. pmc Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration
    S Schilling
    Institute for Multiple Sclerosis Research, University of Goettingen, Goettingen, Germany
    Clin Exp Immunol 145:101-7. 2006
    ..We conclude that the underlying biological activity of FAE in EAE is complex and, to elucidate the molecular mechanisms, further investigation is needed...
  32. pmc Growth of Campylobacter jejuni supported by respiration of fumarate, nitrate, nitrite, trimethylamine-N-oxide, or dimethyl sulfoxide requires oxygen
    Michael J Sellars
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    J Bacteriol 184:4187-96. 2002
    ..The results indicate that strict anaerobiosis is a stress condition for C. jejuni but that alternative respiratory pathways can contribute significantly to energy conservation under oxygen-limited conditions, as might be found in vivo...
  33. pmc Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis
    Vivek P Singh
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine, Scott and White, Central Texas Veterans Health Care System, Temple, TX, USA
    Diabetes 57:3297-306. 2008
    ..In the present study, we determined whether hyperglycemia activates the cardiac intracellular renin-Ang system (RAS) in vivo and whether ARBs, ACE, or renin inhibitors block synthesis and effects of intracellular Ang II (iAng II)...
  34. ncbi Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker
    Eoin O'Brien
    Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Hypertension 49:276-84. 2007
    ....
  35. pmc Effects of fumaric acids on cuprizone induced central nervous system de- and remyelination in the mouse
    Darius Moharregh-Khiabani
    Department of Neurology, Hannover Medical School, Hannover, Germany
    PLoS ONE 5:e11769. 2010
    ..One of the suggested modes of action is the potential of FAE to exert a neuroprotective effect...
  36. ncbi The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor?
    A H Jan Danser
    Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Hypertens Res 33:4-10. 2010
    ....
  37. ncbi Fumaric acid esters
    Martin Rostami Yazdi
    Psoriasis Center at the Department of Dermatology, University of Kiel, Kiel, Germany
    Clin Dermatol 26:522-6. 2008
    ..Currently, there are few data on the pharmacokinetics of fumarates in human beings. DMF seems to act as a prodrug for its main metabolite: monomethylfumarate...
  38. ncbi Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOS
    Henry Krum
    Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University Alfred Hospital, Melbourne VIC 3004, Australia
    Eur J Heart Fail 13:107-14. 2011
    ..Perspective The ATMOSPHERE study will definitively determine the role of a DRI strategy additional to or as an alternative to conventional RAAS blockade in patients with chronic systolic HF...
  39. pmc The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling
    Sandra Feldt
    Experimental and Clinical Research Center, Max Delbruck Center, Lindenberger Weg 80, 13125 Berlin, Germany
    J Am Soc Nephrol 19:743-8. 2008
    ..In addition, the in vitro data do not support the use of the HRP to block AngII-independent prorenin- or renin-mediated effects...
  40. ncbi Efficacy and safety of aliskiren in Japanese hypertensive patients with renal dysfunction
    Sadayoshi Ito
    Division of Nephrology, Endocrinology and Vascular Medicine, Department of Clinical Medicine, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Hypertens Res 33:62-6. 2010
    ..Aliskiren was well tolerated with no new safety concerns in Japanese hypertensive patients with renal dysfunction...
  41. ncbi Rationale and design of the multicentre, randomized, double-blind, placebo-controlled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT)
    Mihai Gheorghiade
    Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N Michigan Avenue, Suite 1006, Chicago, IL 60611, USA
    Eur J Heart Fail 13:100-6. 2011
    ..The aim of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) study is to evaluate the effect of aliskiren on cardiovascular death and HF in AHFS patients...
  42. pmc Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites
    Anna Serra-Pérez
    Department of Brain Ischemia and Neurodegeneration, Institute of Biomedical Research of Barcelona, Consejo Superior de Investigaciones Cientificas, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    J Biol Chem 285:18217-24. 2010
    ....
  43. ncbi Suppression of VEGFR2 expression in human endothelial cells by dimethylfumarate treatment: evidence for anti-angiogenic action
    Markus Meissner
    Department of Dermatology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Invest Dermatol 131:1356-64. 2011
    ..Inhibition of VEGFR-2 is shown to be one critical aspect in DMF-mediated anti-angiogenic effects...
  44. ncbi Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren
    Jan H Schefe
    Center for Cardiovascular Research CCR Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, Berlin, Germany
    J Hypertens 26:1787-94. 2008
    ..The effects of prorenin and of renin inhibitors on the signal transduction cascade of the (pro)renin receptor are currently unknown...
  45. ncbi Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice
    Eiichiro Yamamoto
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjyo, Kumamoto, Japan
    Hypertension 54:633-8. 2009
    ..The combination of aliskiren and valsartan seems to be a promising therapeutic strategy for hypertensive organ injury caused by endothelial NO synthase dysfunction...
  46. pmc Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency
    Nicola Ternette
    Central Proteomics Facility, Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, UK
    Cell Rep 3:689-700. 2013
    ..Our data provide evidence that succination, resulting from FH deficiency, targets and potentially alters the function of multiple proteins and may contribute to the dysregulated metabolism observed in HLRCC...
  47. ncbi Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study
    Sydney C W Tang
    Nephrology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Nephrol Dial Transplant 27:613-8. 2012
    ..Its potential efficacy in nondiabetic chronic kidney diseases that are driven by renin-angiotensin system activation remains to be explored...
  48. ncbi IκBα glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES
    P Seidel
    Respiratory Research Group, Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Eur Respir J 38:1444-52. 2011
    ..Our findings offer new potential drug targets to reduce airway inflammation in asthma...
  49. ncbi Dimethylfumarate for psoriasis: more than a dietary curiosity
    Ulrich Mrowietz
    Department of Dermatology, University Clinic of Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    Trends Mol Med 11:43-8. 2005
    ..Recent evidence also shows that these effects are mediated through the interference of the intracellular redox system by DMF. Here, the mode of action of FAE and its clinical use for psoriasis will be discussed...
  50. pmc Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy
    Frederik Persson
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 33:2304-9. 2010
    ..This post hoc analysis assessed the efficacy and safety of aliskiren added to the maximal recommended dose of losartan according to baseline estimated GFR (eGFR) (stage 1-3 chronic kidney disease [CKD])...
  51. ncbi Inhibition of NF-κB and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts
    Petra Seidel
    Pulmonary Cell Research, Department of Biomedicine and Pneumology, University Hospital Basel, Switzerland
    Swiss Med Wkly 140:w13132. 2010
    ....
  52. pmc DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1
    Petra Seidel
    Pulmonary Cell Research, University Hospital Basel, Switzerland
    Respir Res 11:145. 2010
    ..In addition, DMF altered intracellular glutathione levels and thereby reduced proliferation of other cell types...
  53. pmc Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection
    Stephanie A Cross
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 187:5015-25. 2011
    ..We propose that dysregulation of the antioxidant response during HIV infection drives macrophage-mediated neurotoxicity and that DMF could serve as an adjunctive neuroprotectant and HIV disease modifier in ART-treated individuals...
  54. ncbi Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity
    Norma Frizzell
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Biochem J 445:247-54. 2012
    ..We propose that increased succination of proteins is an early marker of glucotoxicity and mitochondrial stress in adipose tissue in diabetes...
  55. pmc Aliskiren in combination with losartan reduces albuminuria independent of baseline blood pressure in patients with type 2 diabetes and nephropathy
    Frederik Persson
    Steno Diabetes Center, Niels Steensensvej 1, DK 2820 Gentofte, Denmark
    Clin J Am Soc Nephrol 6:1025-31. 2011
    ..Our post hoc analysis assessed the baseline BP influence on the antiproteinuric effect in the Aliskiren in the Evaluation of Proteinuria in Diabetes (AVOID) study...
  56. ncbi A study of dose-proportionality in the pharmacokinetics of the oral direct renin inhibitor aliskiren in healthy subjects
    D Limoges
    Novartis Pharma AG, Basel, Switzerland
    Int J Clin Pharmacol Ther 46:252-8. 2008
    ..To evaluate the dose-proportionality of the pharmacokinetics of aliskiren, the first in a new class of orally active direct renin inhibitors approved for the treatment of hypertension...
  57. pmc The dual-functioning fumarate reductase is the sole succinate:quinone reductase in Campylobacter jejuni and is required for full host colonization
    Rebecca A Weingarten
    Department of Microbiology, North Carolina State University, Campus Box 7615, Raleigh, NC 27695, USA
    J Bacteriol 191:5293-300. 2009
    ....
  58. ncbi Aliskiren ameliorates chlorhexidine digluconate-induced peritoneal fibrosis in rats
    Chun Yen Ke
    Tzu Chi University, Hualien, Taiwan
    Eur J Clin Invest 40:301-9. 2010
    ..The present study was designed to investigate the protective effects of aliskiren on chlorhexidine digluconate-induced PF in rats...
  59. ncbi Aliskiren and perindopril reduce the levels of transforming growth factor-β in patients with non-diabetic kidney disease
    Sławomir Lizakowski
    Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Am J Hypertens 25:636-9. 2012
    ....
  60. ncbi Dimethylfumarate inhibits CXCL10 via haem oxygenase-1 in airway smooth muscle
    Petra Seidel
    Dept of Biomedicine and Pneumology, Dept of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur Respir J 41:195-202. 2013
    ..In human primary ASMCs, DMF inhibits CXCL10 secretion by reducing the cellular glutathione level and by activation of p38 MAPK and HO-1. Therefore, DMF may reduce airway inflammation in asthma by a glucocorticoid-independent pathway...
  61. ncbi A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren
    Wen Pyng Wu
    Graduate Institute of Clinical Medical Science, China Medical University, China
    Am J Physiol Renal Physiol 299:F929-41. 2010
    ..In conclusion, a direct renin inhibitor in conjunction with an angiotensin II receptor blocker exerts increased renal protection against renal fibrosis and inflammation during obstruction over either agent alone...
  62. ncbi Renin-angiotensin system dual blockade using angiotensin receptor plus aliskiren decreases severe proteinuria in kidney transplant recipients
    V Lopez
    Nephrology Department, Hospital Universitario Carlos Haya, Malaga, Spain
    Transplant Proc 42:2883-5. 2010
    ....
  63. ncbi Beneficial effect of aliskiren combined with olmesartan in reducing urinary protein excretion in patients with chronic kidney disease
    Takahito Moriyama
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Kawada cho 8 1, Shinjyuku ku, Tokyo 162 8666, Japan
    Int Urol Nephrol 44:841-5. 2012
    ..Blockade of the renin-angiotensin-aldosterone system is a therapeutic mainstay in patients with chronic kidney disease (CKD). However, the renoprotective effect of the novel direct renin inhibitor aliskiren is unknown...
  64. ncbi Fumaric acid and its esters: an emerging treatment for multiple sclerosis with antioxidative mechanism of action
    R Gold
    Department of Neurology, St Josef Hospital Ruhr University Bochum, Bochum, Germany
    Clin Immunol 142:44-8. 2012
    ..A phase II clinical trial in relapsing-remitting multiple sclerosis (RRMS) patients with dimethylfumarate showed a significant reduction in the number of gadolinium enhancing lesions after 24weeks...
  65. pmc Blocking the RAAS at different levels: an update on the use of the direct renin inhibitors alone and in combination
    Francesca Cagnoni
    Internal Medicine, Ospedale Unificato Broni Stradella, Stradella PV, Italy
    Vasc Health Risk Manag 6:549-59. 2010
    ..Renin system blockade with aliskiren and another RAAS agent has been, and still is, the subject of many large-scale clinical trials and furthermore, is already available in some countries as a fixed combination...
  66. pmc Transient alteration of cellular redox buffering before irradiation triggers apoptosis in head and neck carcinoma stem and non-stem cells
    Anthony Boivin
    Universite de Lyon, Université Lyon I, Lyon, France
    PLoS ONE 6:e14558. 2011
    ..The major focus of this work was to design a transient glutathione depleting strategy during the course of irradiation of HNSCC in order to overcome their radioresistance associated with redox adaptation...
  67. ncbi Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress
    Ryoji Nagai
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    J Biol Chem 282:34219-28. 2007
    ..We propose that the increase in fumarate and 2SC is the result of mitochondrial stress in the adipocyte during adipogenesis and that 2SC may be a useful biomarker of mitochondrial stress in obesity, insulin resistance, and diabetes...
  68. pmc Periplasmic electron transfer via the c-type cytochromes MtrA and FccA of Shewanella oneidensis MR-1
    Bjoern Schuetz
    Universitat Freiburg, Institut Biologie II, Mikrobiologie, Schänzlestr 1, D 79104 Freiburg, Germany
    Appl Environ Microbiol 75:7789-96. 2009
    ..oneidensis. Hence, FccA could function in both the electron transport to fumarate and via MtrA to mineral-phase Fe(III). Growth experiments with a DeltafccA deletion mutant suggest a role of FccA as a transient electron storage protein...
  69. pmc Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors
    Ferdia A Gallagher
    Cancer Research United Kingdom, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom
    Proc Natl Acad Sci U S A 106:19801-6. 2009
    ..Given that fumarate is an endogenous molecule, this technique has the potential to be used clinically...
  70. ncbi Graphite electrodes as electron donors for anaerobic respiration
    Kelvin B Gregory
    University of Massachusetts, Department of Microbiology, 203 Morrill IV North, Amherst, MA 01003, USA
    Environ Microbiol 6:596-604. 2004
    ..This finding has implications for the harvesting of electricity from anaerobic sediments and the bioremediation of oxidized contaminants...
  71. ncbi S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate
    Nathan L Alderson
    Department of Chemistry and Biochemistry, University of South Carolina, USA
    Arch Biochem Biophys 450:1-8. 2006
    ..These observations identify fumarate as an endogenous electrophile and suggest a role for fumarate in regulation of metabolism...
  72. ncbi Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells
    Wendy W Batenburg
    Erasmus MC, 3015 GE Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 28:1151-7. 2008
    ..We also investigated whether aliskiren affects (pro)renin binding to its receptors, using rat aortic vascular smooth muscle cells (VSMCs) overexpressing the h(P)RR...
  73. ncbi Oral renin inhibitors
    Jan A Staessen
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Lancet 368:1449-56. 2006
    ..This Review summarises the development of oral renin inhibitors and their pharmacokinetic and pharmacodynamic properties, with a focus on aliskiren...
  74. ncbi Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
    Jeanette M Wood
    Novartis Institute for Biomedical Research, Basel, Switzerland
    J Hypertens 23:417-26. 2005
    ..We report the results of animal experiments performed in marmosets and rats in order to characterize aliskiren before its recent investigation in humans...
  75. ncbi Differential metabolic consequences of fumarate hydratase and respiratory chain defects
    Nuno Raimundo
    Program of Molecular Neurology Biomedicum Helsinki, Finland
    Biochim Biophys Acta 1782:287-94. 2008
    ..The lack of cytoplasmic form of FH and the reduced redox environment were typical for all FH-mutant lines, and their role in FH-related tumorigenesis requires further attention...
  76. ncbi Dimethylfumarate inhibits NF-{kappa}B function at multiple levels to limit airway smooth muscle cell cytokine secretion
    P Seidel
    Department of Research and Pneumology, University Hospital Basel, Switzerland
    Am J Physiol Lung Cell Mol Physiol 297:L326-39. 2009
    ..These data suggest that DMF downregulates cytokine secretion not only by inhibiting NF-kappaB but a wider range of NF-kappaB-linked signaling proteins, which may explain its potential beneficial effect in asthma...
  77. ncbi The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells
    T J Stoof
    Department of Dermatology, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Br J Dermatol 144:1114-20. 2001
    ..The effectiveness of systemic treatment of psoriasis with fumaric acid esters has been proven, but their mode of action at the cellular and molecular level has not yet been fully elucidated...
  78. ncbi Treatment of severe psoriasis with fumaric acid esters: scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference
    U Mrowietz
    Department of Dermatology, University of Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    Br J Dermatol 141:424-9. 1999
    ..This article reviews the experimental and clinical information on FAEs in psoriasis and provides guidelines for the clinical use of FAEs derived from a consensus meeting of leading experts...
  79. ncbi Monomethylfumarate affects polarization of monocyte-derived dendritic cells resulting in down-regulated Th1 lymphocyte responses
    Nicolle H R Litjens
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 34:565-75. 2004
    ..In addition, MMF inhibited LPS-induced NF-kappaB activation in DC. Together, beneficial effects of FAE in psoriasis involve modulation of DC polarization by MMF such that these cells down-regulate IFN-gamma production by Th cells...
  80. ncbi Dimethylfumarate for psoriasis: Pronounced effects on lesional T-cell subsets, epidermal proliferation and differentiation, but not on natural killer T cells in immunohistochemical study
    H Jorn Bovenschen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Am J Clin Dermatol 11:343-50. 2010
    ..Oral fumaric acid esters are an effective therapy for psoriasis and are believed to exert their effects mainly through their anti-inflammatory properties...
  81. ncbi Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate
    L Palmieri
    The M R C Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 417:114-8. 1997
    ..This exchange activity and the subsequent conversion of fumarate to oxaloacetate in the cytosol would be essential for the growth of S. cerevisiae on ethanol or acetate as the sole carbon source...
  82. ncbi Reversing the effects of formalin fixation with citraconic anhydride and heat: a universal antigen retrieval method
    Shigeki Namimatsu
    Department of Surgical Pathology, Nippon Medical School Hospital, Tokyo, Japan
    J Histochem Cytochem 53:3-11. 2005
    ..It also allows standardization of immunohistochemistry for formalin-fixed tissues in pathology laboratories, eliminating inter-laboratory discrepancies in results for accurate clinical and research studies...
  83. pmc Safety and tolerability of the direct renin inhibitor aliskiren: a pooled analysis of clinical experience in more than 12,000 patients with hypertension
    William B White
    Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT 06030 3940, USA
    J Clin Hypertens (Greenwich) 12:765-75. 2010
    ..At the registered doses of 150 mg and 300 mg daily, aliskiren has safety and tolerability profiles similar to placebo, other RAS blockers, and diuretics. Cough rates are lower with aliskiren compared with ACE inhibitors...
  84. ncbi Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-kappa B1, but not RelA in normal human dermal fibroblast cells
    M Vandermeeren
    Janssen Research Foundation, Beerse, Belgium
    J Invest Dermatol 116:124-30. 2001
    ....
  85. pmc Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress
    Matthew Blatnik
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    Diabetes 57:41-9. 2008
    ..We investigated the role of fumarate in chemical modification and inhibition of the sulfhydryl enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), in vitro and in tissues of diabetic rats...
  86. ncbi Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine--preparation of S-substituted thiosuccinic acid esters
    Thomas J Schmidt
    Westfalische Wilhelms Universitat, Institut für Pharmazeutische Biologie und Phytochemie IPBP, Hittorfstrasse 56, D 48149 Munster, Germany
    Bioorg Med Chem 15:333-42. 2007
    ..On the other hand, MHF, due to its slow reaction with GSH, may have higher chances than DMF to react with more essential thiol groups in macromolecules...
  87. ncbi Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione
    Maike M Schmidt
    Center for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany
    Neurochem Int 57:460-7. 2010
    ..These data demonstrate that acute exposure to fumaric acid diesters deprives astrocytes of their GSH, most likely by the reaction of the reactive alpha,beta-unsaturated diesters with GSH...
  88. ncbi Fumaric acid dialkyl esters deprive cultured rat oligodendroglial cells of glutathione and upregulate the expression of heme oxygenase 1
    Anette Thiessen
    Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany
    Neurosci Lett 475:56-60. 2010
    ..Thus, alterations in glutathione and heme oxygenase metabolism have to be considered when oligodendrocytes are exposed to fumaric acid dialkyl esters...
  89. ncbi Renal protective effects of aliskiren beyond its antihypertensive property in a mouse model of progressive fibrosis
    Oliver Gross
    Department of Nephrology and Rheumatology, University Medicine Goettingen, Germany
    Am J Hypertens 24:355-61. 2011
    ..This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model for progressive renal fibrosis...
  90. ncbi Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment
    Sujata Vaidyanathan
    Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA
    Clin Pharmacokinet 46:661-75. 2007
    ..This study assessed the effects of renal impairment on the pharmacokinetics and safety of aliskiren alone and in combination with the angiotensin receptor antagonist irbesartan...
  91. ncbi Native and modified lactate dehydrogenase expression in a fumaric acid producing isolate Rhizopus oryzae 99-880
    Christopher D Skory
    Bioproducts and Biocatalysis Research Unit, National Center for Agricultural Utilization Research, USDA, Agricultural Research Service, 1815 N University Street, Peoria, IL 61604, USA
    Curr Genet 52:23-33. 2007
    ..Additionally, transformed isolates grown with glucose accumulated up to 27 g lactic acid/l with a concurrent decrease in fumaric acid, ethanol, and glycerol compared with the untransformed and vector-transformed control strains...
  92. ncbi Aliskiren: renin inhibitor for hypertension management
    Judy W M Cheng
    Massachusetts College of Pharmacy and Health Sciences and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Ther 30:31-47. 2008
    ..Certain agents that modify the RAAS can control blood pressure and improve cardiovascular outcomes. Aliskiren is the first of a new class of antihypertensive agents known as renin inhibitors...
  93. ncbi Renin inhibition with aliskiren: where are we now, and where are we going?
    Michel Azizi
    Clinical Investigation Center 9201, Hospital European Georges Pompidou, Paris, France
    J Hypertens 24:243-56. 2006
    ..The relevant and necessary studies are ongoing...
  94. ncbi Optimal antiproteinuric dose of aliskiren in type 2 diabetes mellitus: a randomised crossover trial
    F Persson
    Steno Diabetes Center, Niels Steensenvej 1, DK 2820 Gentofte, Denmark
    Diabetologia 53:1576-80. 2010
    ..The optimal antiproteinuric dose of aliskiren is unknown. This study compared the effect of placebo and increasing doses of aliskiren on urinary albumin excretion rate (UAER)...
  95. ncbi Efficacy of aliskiren in Japanese chronic kidney disease patients with hypertension
    Yukinao Sakai
    Division of Nephrology, Department of Internal Medicine, Nippon Medical School Musashikosugi Hospital, Kawasaki, Japan
    Ren Fail 34:442-7. 2012
    ..This study attempted to provide insight into this mechanism by examining the antihypertensive and renoprotective effects of aliskiren in hypertensive chronic kidney disease (CKD) patients...
  96. ncbi Safety and efficacy of aliskiren in the treatment of hypertension: a systematic overview
    Fabio Angeli
    Hospital Media Valle del Tevere Pantalla, AUSL 2 Umbria, Department of Cardiology, Section of Cardiology, Perugia, Italy
    Expert Opin Drug Saf 11:659-70. 2012
    ..Aliskiren's inhibitory effect on angiotensin I generation, through renin blockade, is highly specific and long-lasting (24 hours). This feature differentiates aliskiren from traditional antihypertensive drugs...
  97. ncbi Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertension
    Anne Catherine Pouleur
    Brigham and Women s Hospital, Boston, MA 02115, USA
    J Renin Angiotensin Aldosterone Syst 12:483-90. 2011
    ..High circulating aldosterone levels stimulate myocardial fibrosis and left ventricular hypertrophy (LVH). However, it is not clear whether suppression of aldosterone directly contributes to LVH regression in hypertensive patients...
  98. pmc Effect of aliskiren on proteinuria in non-diabetic chronic kidney disease: a double-blind, crossover, randomised, controlled trial
    Sławomir Lizakowski
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Int Urol Nephrol 44:1763-70. 2012
    ..To evaluate the proteinuria-lowering effect of a renin inhibitor (aliskiren), compared to placebo and to an angiotensin-converting enzyme inhibitor (perindopril), in patients with non-diabetic chronic kidney disease...
  99. ncbi Fumarates vs. methotrexate in moderate to severe chronic plaque psoriasis: a multicentre prospective randomized controlled clinical trial
    S Fallah Arani
    Department of Dermatology and Venereology Department of Biostatistics, Erasmus MC, University Medical Center Rotterdam, 3015 CA Rotterdam, The Netherlands
    Br J Dermatol 164:855-61. 2011
    Methotrexate and fumarates are effective systemic therapies for moderate to severe psoriasis according to the European S3 guidelines.
  100. pmc Reconstruction of cytosolic fumaric acid biosynthetic pathways in Saccharomyces cerevisiae
    Guoqiang Xu
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
    Microb Cell Fact 11:24. 2012
    ..Fumaric acid is a commercially important component of foodstuffs, pharmaceuticals and industrial materials, yet the current methods of production are unsustainable and ecologically destructive...
  101. ncbi Fumarate esters as angiogenesis inhibitors: key to action in psoriasis?
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Invest Dermatol 131:1189-91. 2011
    ..Fumarate, a natural product that is generated internally in humans during the Krebs cycle, is an attractive alternative to these therapies. However, the mechanism for fumarate's activity in psoriasis remains unknown...

Research Grants40

  1. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  2. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  3. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  4. DIETARY SALT INTAKE AND THE METABOLIC EFFECTS OF INSULIN
    Raymond Townsend; Fiscal Year: 2003
    ..If increased salt intake improves insulin sensitivity this should prompt a re-evaluation of the benefits of recommending a lower sodium intake in normotensive people. ..
  5. FLAVANOL-RICH COCOA TO REVERSE VASCULAR DISEASE OF AGING
    Naomi Fisher; Fiscal Year: 2006
    ..She will be well-positioned to submit an application for an RO1 with results from this study. Therapeutic interventions aimed at restoring vascular endothelial function hold tremendous clinical promise. ..
  6. DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIA
    Mark A Geyer; Fiscal Year: 2010
    ..Hence, Aim 3 studies will test the hypothesized differential roles of specific CRF receptors in mediating isolation rearing-induced deficits in PPI in mice, using CRF-R1 and CRF-R2 null mutant mice. ..
  7. Serotonin Club IUPHAR Satellite Meeting
    Mark Geyer; Fiscal Year: 2006
    ..Hence, helping neuroscientists-in-training attend the meeting will have a positive influence on trainees and a lasting impact on the field. [unreadable] [unreadable] [unreadable]..
  8. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2007
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation [unreadable] [unreadable]..
  9. Hyperpolarized High Field NMR Facility For Metabolic Profiling Of Human Disease
    John Kurhanewicz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. CELLULAR PATHOPHYSIOLOGY OF ACUTE RENAL FAILURE
    Joel Weinberg; Fiscal Year: 2007
    ..abstract_text> ..
  11. Brain Atrophy/Diffusion Tensor Study/Multiple Sclerosis
    Robert Fox; Fiscal Year: 2008
    ..Furthermore, these studies should help develop improved methods for evaluating new therapeutic strategies for neuroprotection and neuroregeneration. ..
  12. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2009
    ....
  13. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  14. Improving Outcomes in Diabetic Nephropathy
    Robert Toto; Fiscal Year: 2008
    ..PERFORMANCE SITE ========================================Section End=========================================== ..
  15. MODERATE ALCOHOL USE--CARDIOVASCULAR RISKS AND BENEFITS
    Thomas Giles; Fiscal Year: 2001
    ..The exacerbation or prevention of EIH will be related to drug effects on the cell-signaling pathway. This research can define the cell-signaling pathway in EIH and provide new and novel approaches to treating EIH. ..
  16. BIOADHESIVE MICROSPHERES
    Edith Mathiowitz; Fiscal Year: 2001
    ..The end goal is to move these novel drug delivery systems from research to clinical applications for treatment of diseases. ..
  17. TRAINING CURRICULUM IN PATIENT ORIENTED RESEARCH
    Robert Toto; Fiscal Year: 2004
    ..The proposed program will provide young physicians and scientists with the skills needed to conduct clinical investigations and to compete for federal and non-federal research funding. ..
  18. DIABETES AND BLADDER SMOOTH MUSCLE METABOLIC DYSFUNCTION
    CHRISTOPHER HARDIN; Fiscal Year: 2002
    ..These experiments will provide fundamental insights to the normal metabolism of the bladder smooth muscle and to the pathological metabolic changes associated with diabetes. ..
  19. BIOADHESIVE MICROSPHERES
    Edith Mathiowitz; Fiscal Year: 2002
    ..The end goal is to move these novel drug delivery systems from research to clinical applications for treatment of diseases. ..
  20. African American Study of Kidney Disease and Hypertensi*
    Robert Toto; Fiscal Year: 2007
    ..Such results might eventually lead to new strategies that delay or prevent ESRD. ..
  21. Lipoproteins, HIV, and Antiretroviral Therapy in SMART
    Daniel Duprez; Fiscal Year: 2008
    ..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  22. MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSI
    John Kurhanewicz; Fiscal Year: 2008
    ..This is a translational project intended to provide new biochemical information about prostate cancer before and after radiation therapy and to aid in the translation of this technology into clinical practice. [unreadable] [unreadable]..
  23. Vitamin D and Diabetic Nephropathy
    Yan Chun Li; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. MECHANISMS OF RENAL TUBULAR EPITHELIAL CELL INJURY
    Sudhir Shah; Fiscal Year: 2005
    ..abstract_text> ..
  25. STARTLE GATING AND LOCOMOTION IN D2-FAMILY KNOCKOUT MICE
    Mark Geyer; Fiscal Year: 2004
    ..This information will have important implications for the further development of therapeutic approaches to the treatment of both schizophrenia and drug abuse. ..
  26. GORDON CONF. MACROMOLECULAR ORGANIZATION & CELL FUNCTION
    CHRISTOPHER HARDIN; Fiscal Year: 2004
    ..Although much of the program is now in place, a number of slots are being kept open for presentations on the most recent developments in this rapidly-moving field, which will be filled early next year. ..
  27. Metabolic Organization by the Caveolae and Cytoskeleton
    CHRISTOPHER HARDIN; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  28. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  29. Redox Control of Radiation Response
    John Biaglow; Fiscal Year: 2006
    ..Ultimately, we hope to develop specific strategies for modifying thiol redox homeostasis in vivo, to make human tumors more sensitive to ionizing radiation. ..
  30. Hyperpolarized 13c NMR Studies of Prostate Cancer (RMI)
    John Kurhanewicz; Fiscal Year: 2008
    ....
  31. RACE, RENIN, GENES, RISK, AND DIABETIC NEPHROPATHY
    NORMAN HOLLENBERG; Fiscal Year: 2002
    ..Our goal in this study is to explore preliminary evidence that RAS activation accounts for many Type 2 DM features involving renal risk, and racial differences in risk. ..
  32. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2003
    ..abstract_text> ..
  33. Estrogen Modulates Injury-Induced Inflammation
    Suzanne Oparil; Fiscal Year: 2007
    ..These fundamental mechanistic studies will enhance our understanding of the pathobiology of vascular disease, particularly as it occurs in aging women, and will provide the basis for development of novel therapeutic strategies. ..
  34. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2003
    ..These fundamental mechanistic studies will establish more rational strategies for therapeutic intervention in vascular diseases, including the basis for future gene therapy. ..
  35. Preventive Role of VDR in Colorectal Carcinogenesis
    Yan Chun Li; Fiscal Year: 2006
    ....
  36. Regulation of minerals and fluids excretion in vitamin D
    Yan Chun Li; Fiscal Year: 2005
    ..The third goal is to study the effect of VDR inactivation on ANP expression and sodium and body fluid balance, in order to test in vivo, the hypothesis that 1,25(OH)2D3 negatively regulates ANP expression. ..
  37. ANG II AND IGF-1 INTERACTION IN CARDIOVASCULAR TISSUE
    James Sowers; Fiscal Year: 2003
    ..Thus, the proposed investigation will explore the role of PI3-kinase in mediating the cardiovascular interactions of AngII/IGF-1 after both short-term in vitro Ang II exposure and longer-term in vivo Ang II tissue excess. ..
  38. BIFUNCTIONAL OPIOID/CCK LIGANDS FOR PAIN
    Frank Porreca; Fiscal Year: 2006
    ..This novel mechanism of action should yield therapeutic utility as well as provide an increased understanding of opioid-CCK interactions in normal and pathological pain states. ..
  39. Opioid and Non-Opioid Actions of Dynorphin in Pain
    Frank Porreca; Fiscal Year: 2005
    ..As most clinical conditions of neuropathic pain are treated in the post-injury (i.e., maintenance) state, such information may allow approaches to limit or reverse the pathological actions of dynorphin in maintaining neuropathic pain. ..