carbamates

Summary

Summary: Salts or esters of carbamic acid, H2NC(=O)OH, or of N-substituted carbamic acids: R2NC(=O)OR', (R' = hydrocarbyl or a cation). The esters are often called URETHANE or urethan, a usage that is strictly correct only for the ethyl esters. (From IUPAC [Internet]. International Union Of Pure And Applied Chemistry; c1995 [updated 2004 Jan 9; cited 2004 May 3]. Available from http://www.chem.qmul.ac.uk/iupac/class/oneN.html#35/).

Top Publications

  1. ncbi KCNQ/M currents in sensory neurons: significance for pain therapy
    Gayle M Passmore
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:7227-36. 2003
  2. pmc A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
    Jacqueline L Blankman
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 14:1347-56. 2007
  3. ncbi The contribution of Kv7 channels to pregnant mouse and human myometrial contractility
    Laura A McCallum
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London, St Thomas Hospital Campus, London, UK
    J Cell Mol Med 15:577-86. 2011
  4. pmc Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector Anopheles gambiae homozygous for the G119S mutation
    Luc Djogbenou
    Institut Régional de Santé Publique Université d Abomey Calavi, Cotonou, Benin
    Malar J 9:12. 2010
  5. ncbi An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of the peach potato aphid, Myzus persicae
    Takeshi Nabeshima
    Laboratory of Applied Zoology E407, Department of Agriculture and Forestry, Institute of Agriculture and Forestry, University of Tsukuba, Tennodai 1 1 1, Ibaraki, 305 8572, Japan
    Biochem Biophys Res Commun 307:15-22. 2003
  6. ncbi Behavioural and insecticidal effects of organophosphate-, carbamate- and pyrethroid-treated mosquito nets against African malaria vectors
    R C Malima
    Amani Centre, National Institute for Medical Research, Muheza, Tanzania
    Med Vet Entomol 23:317-25. 2009
  7. ncbi Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
    Adrian Blaser
    Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    J Med Chem 55:312-26. 2012
  8. pmc Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy
    Lioubov I Brueggemann
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Maywood, IL 60153, USA
    Am J Physiol Lung Cell Mol Physiol 302:L120-32. 2012
  9. ncbi Carbamoylation of glomerular and tubular proteins in patients with kidney failure: a potential mechanism of ongoing renal damage
    L M Kraus
    Department of Molecular Science, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Swiss Med Wkly 131:139-4. 2001
  10. pmc Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models
    Angelo Jayamanne
    Pain Management Research Institute, Northern Clinical School, The University of Sydney, NSW, Australia
    Br J Pharmacol 147:281-8. 2006

Detail Information

Publications332 found, 100 shown here

  1. ncbi KCNQ/M currents in sensory neurons: significance for pain therapy
    Gayle M Passmore
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:7227-36. 2003
    ..It is suggested that IK(M) plays a key role in controlling the excitability of nociceptors and may represent a novel analgesic target...
  2. pmc A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
    Jacqueline L Blankman
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 14:1347-56. 2007
    ..Interestingly, MAGL, ABHD6, and ABHD12 display distinct subcellular distributions, suggesting that they may control different pools of 2-AG in the nervous system...
  3. ncbi The contribution of Kv7 channels to pregnant mouse and human myometrial contractility
    Laura A McCallum
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London, St Thomas Hospital Campus, London, UK
    J Cell Mol Med 15:577-86. 2011
    ..Consequently, activation of the encoded channels represents a novel mechanism for treatment of preterm labour...
  4. pmc Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector Anopheles gambiae homozygous for the G119S mutation
    Luc Djogbenou
    Institut Régional de Santé Publique Université d Abomey Calavi, Cotonou, Benin
    Malar J 9:12. 2010
    ..gambiae, especially for homozygous individuals, and these costs could be influential in determining the frequency of carbamate resistance in these populations...
  5. ncbi An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of the peach potato aphid, Myzus persicae
    Takeshi Nabeshima
    Laboratory of Applied Zoology E407, Department of Agriculture and Forestry, Institute of Agriculture and Forestry, University of Tsukuba, Tennodai 1 1 1, Ibaraki, 305 8572, Japan
    Biochem Biophys Res Commun 307:15-22. 2003
    ..However, a single amino acid substitution of Ser431Phe on MpAchE2 was found in the pirimicarb resistant strains. This substitution was located in the acyl pocket of the enzyme and was thought to alter the ligand specificity...
  6. ncbi Behavioural and insecticidal effects of organophosphate-, carbamate- and pyrethroid-treated mosquito nets against African malaria vectors
    R C Malima
    Amani Centre, National Institute for Medical Research, Muheza, Tanzania
    Med Vet Entomol 23:317-25. 2009
    ..Chlorpyrifos-methyl was inferior to deltamethrin in terms of mortality and blood-feeding inhibition and would be better deployed on a net in combination with a pyrethroid to control insecticide-resistant mosquitoes...
  7. ncbi Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
    Adrian Blaser
    Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    J Med Chem 55:312-26. 2012
    ....
  8. pmc Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy
    Lioubov I Brueggemann
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Maywood, IL 60153, USA
    Am J Physiol Lung Cell Mol Physiol 302:L120-32. 2012
    ....
  9. ncbi Carbamoylation of glomerular and tubular proteins in patients with kidney failure: a potential mechanism of ongoing renal damage
    L M Kraus
    Department of Molecular Science, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Swiss Med Wkly 131:139-4. 2001
    ..Cyanate formed spontaneously from urea carbamoylates non-protonated amino groups of protein, irreversibly altering function, charge and structure. Carbamoylated proteins in renal tissue have not been examined hitherto...
  10. pmc Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models
    Angelo Jayamanne
    Pain Management Research Institute, Northern Clinical School, The University of Sydney, NSW, Australia
    Br J Pharmacol 147:281-8. 2006
    ..These findings suggest that the FAAH inhibitor URB597 produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states, without causing the undesirable side effects associated with cannabinoid receptor activation...
  11. pmc KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus
    V Ipavec
    Institute of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L go F Vito 1, 00168 Rome, Italy
    Pharmacol Res 64:397-409. 2011
    ..KV7 channel activators could be useful relaxant agents of the gastric smooth muscle...
  12. pmc Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats
    Wen Xu
    Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China
    Mol Pain 6:49. 2010
    ....
  13. ncbi Enhanced activation of and increased production of matrix metalloproteinase-9 by human blood monocytes upon adhering to carbamylated collagen
    Roselyne Garnotel
    Laboratory of Biochemistry and Molecular Biology, CNRS UMR 6198, IFR 53 Biomolecules, Faculty of Medicine, University of Reims Champagne Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France
    FEBS Lett 563:13-6. 2004
    ..Such alterations may contribute to enhanced atherosclerosis in renal insufficiency, a pathological condition associated with elevated levels of carbamylation...
  14. pmc Vascular KCNQ (Kv7) potassium channels as common signaling intermediates and therapeutic targets in cerebral vasospasm
    Bharath K Mani
    Department of Molecular Pharmacology and Therapeutics, Loyola University, Chicago, Maywood, IL, USA
    J Cardiovasc Pharmacol 61:51-62. 2013
    ..In conclusion, we identify Kv7 channels as common targets of vasoconstrictor spasmogens and as candidates for therapeutic intervention for cerebral vasospasm...
  15. pmc Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles
    Thomas A Jepps
    Division of Basic Medical Sciences, St George s, University of London, London, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 297:G107-15. 2009
    ..Drugs that selectively block K(v)7.4/7.5 might be promising therapeutics for the treatment of motility disorders such as constipation associated with irritable bowel syndrome...
  16. ncbi Protein carbamylation links inflammation, smoking, uremia and atherogenesis
    Zeneng Wang
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Nat Med 13:1176-84. 2007
    ..We propose that protein carbamylation is a mechanism linking inflammation, smoking, uremia and coronary artery disease pathogenesis...
  17. pmc Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis
    Brian C Belyea
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 17:7324-36. 2011
    ..Given its physiologic role in myogenesis and oncogenic role in other human cancers, we hypothesized that aberrant Notch signaling may contribute to RMS tumorigenesis and present novel therapeutic opportunities...
  18. ncbi Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
    Fabricio A Moreira
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, D 55099 Mainz, Germany
    Neuropharmacology 54:141-50. 2008
    ..In addition, it indicates an increased activation of CB1 receptors as a mechanism underlying the effects of FAAH inhibition in two models of anxiety...
  19. ncbi Modulation of ERG channels by XE991
    Pernille Elmedyb
    Department of Medical Physiology, The Panum Institute, The University of Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 100:316-22. 2007
    ..In conclusion, great care should be taken when choosing the concentration of XE991 to use for experiments on native potassium channels or animal studies in order to be able to conclude on selective KCNQ channel-mediated effects...
  20. ncbi Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation
    Darren Fegley
    Department of Pharmacology, University of California, Irvine CA 92697 4625, USA
    J Pharmacol Exp Ther 313:352-8. 2005
    ..The results also suggest that an enzyme distinct from FAAH catalyzes OEA hydrolysis in the duodenum, where this lipid substance acts as a local satiety factor...
  21. ncbi Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors
    Giorgio Tarzia
    Istituto di Chimica Farmaceutica e Tossicologica, Universita degli Studi di Urbino Carlo Bo, Piazza del Rinascimento 6, Italy
    J Med Chem 46:2352-60. 2003
    ..URB524 (N-cyclohexylcarbamic acid biphenyl-3-yl ester, 9g) is the most potent compound of the series (IC(50) = 63 nM) and was therefore selected for further optimization...
  22. ncbi Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs
    Francesco Miceli
    Section of Pharmacology, Department of Neuroscience, University of Naples Federico II, Naples, Italy
    Curr Opin Pharmacol 8:65-74. 2008
    ....
  23. ncbi KV7 channelopathies
    Snezana Maljevic
    Department of Neurology and Epileptology, Center for Neurology, Hertie Institute for Clinical Brain Research, University Hospital Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Pflugers Arch 460:277-88. 2010
    ..We also assess the therapeutic potential of KV7 channels; in particular, how the activation of KV7 channels by the compounds retigabine and R-L3 may be useful for treatment of epilepsy or cardiac arrhythmia...
  24. ncbi Experimental hut comparisons of nets treated with carbamate or pyrethroid insecticides, washed or unwashed, against pyrethroid-resistant mosquitoes
    A N Asidi
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Med Vet Entomol 18:134-40. 2004
    ..After five washes, the Permanet, which is sold as a long-lasting insecticidal product, performed no better than the other nets in our experimental conditions...
  25. pmc Distribution of ace-1R and resistance to carbamates and organophosphates in Anopheles gambiae s.s. populations from Côte d'Ivoire
    Ludovic P Ahoua Alou
    Institut Pierre Richet, BP 47 Abidjan, Cote d Ivoire
    Malar J 9:167. 2010
    ..s. is a critical issue for malaria vector control based on the use of insecticide-treated nets. Carbamates and organophosphates insecticides are regarded as alternatives or supplements to pyrethroids used in nets ..
  26. ncbi Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress
    Marco Bortolato
    Department of Pharmacology, University of California, Irvine, California 92697 4260, USA
    Biol Psychiatry 62:1103-10. 2007
    ....
  27. ncbi Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder
    Frederik Rode
    Neurosearch A S, Ballerup, Denmark
    Eur J Pharmacol 638:121-7. 2010
    ..In conclusion, this study demonstrates an efficacious KCNQ dependent effect of retigabine and XE991 on rat bladder contractility...
  28. pmc The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition
    Maria Scherma
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA
    Neuropharmacology 54:129-40. 2008
    ..Thus, additive interactions between the effects of anandamide on brain reward processes and on anxiety may account for its aversive effects when intravenously administered during FAAH inhibition with URB597...
  29. pmc Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes
    Jessica P Alexander
    The Skaggs Institute for Chemical Biology and Departments of Cell Biology and Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
    Chem Biol 12:1179-87. 2005
    ..However, the mechanism by which carbamates inhibit FAAH remains obscure...
  30. ncbi The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits
    C Rundfeldt
    Department of Pharmacology, Arzneimittelwerk Dresden GmbH, Corporate R and D, ASTA Medica Group, Meibetaner Strasse 35, D 01445, Radebeul, Germany
    Neurosci Lett 282:73-6. 2000
    ..Since the function of this channel is reduced in a hereditary epilepsy syndrome, retigabine may be the first anticonvulsant to directly target the deficit observed in a channelopathy...
  31. ncbi Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels
    Wienke Lange
    Institute of Biochemistry, Christian Albrechts University Kiel, Kiel, Germany
    Mol Pharmacol 75:272-80. 2009
    ..This pocket, which is formed at the interface of two adjacent subunits, may be present only in the open state of the channel, consistent with the idea that retigabine stabilizes an open-channel conformation...
  32. ncbi Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies
    Marco Mor
    Dipartimento Farmaceutico, Universita degli Studi di Parma, Parco Area delle Scienze 27 A, I 43100 Parma, Italy
    J Med Chem 47:4998-5008. 2004
    ..The structure-activity characterization reported here should help optimize the pharmacodynamic and pharmacokinetic properties of this class of compounds...
  33. ncbi Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex
    T Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Cereb Cortex 18:1292-301. 2008
    ....
  34. ncbi Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 re
    Sabatino Maione
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
    J Pharmacol Exp Ther 316:969-82. 2006
    ..Thus, endocannabinoids affect the descending pathways of pain control by acting at either CB1 or TRPV1 receptors in healthy rats...
  35. ncbi Effect of new ethyl and methyl carbamates on Rhipicephalus microplus larvae and adult ticks resistant to conventional ixodicides
    I E Pérez-González
    Programa de Maestría y Doctorado en Ciencias de la Producción y de la Salud Animal, Universidad Nacional Autonoma de Mexico, Mexico
    Vet Parasitol 199:235-41. 2014
    The effects of six new synthetic carbamates on fully engorged females of four Rhipicephalus microplus strains (one reference strain susceptible to conventional ixodicides, two strains multiresistant to ixodicides and one tick field ..
  36. ncbi Effect of new ethyl and methyl carbamates on biological parameters and reproduction of the cattle tick Rhipicephalus microplus
    M G Prado-Ochoa
    Programa de Doctorado en Ciencias de la Producción y de la Salud Animal, Universidad Nacional Autonoma de Mexico, Mexico
    Vet Parasitol 194:49-57. 2013
    The effect of carbamates on engorged female Rhipicephalus microplus ticks and larvae was evaluated using the adult immersion test (AIT) and the larval packet test (LPT), respectively...
  37. ncbi Rhodococcus qingshengii sp. nov., a carbendazim-degrading bacterium
    Jing Liang Xu
    Key Laboratory for Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, People s Republic of China
    Int J Syst Evol Microbiol 57:2754-7. 2007
    ..Based on the phenotypic properties and DNA-DNA hybridization data, strain djl-6(T) (=CGMCC 1.6580(T) =KCTC 19205(T)) is proposed as the type strain of a novel Rhodococcus species, Rhodococcus qingshengii sp. nov...
  38. pmc Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron)
    Dawn M Wong
    Department of Chemistry, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 7:e46712. 2012
    ..Twelve carbamates were then assayed for inhibition of these enzymes...
  39. ncbi SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir /ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients
    Joseph C Gathe
    Therapeutic Concepts, P A, Houston, Texas, USA
    AIDS 18:1529-37. 2004
    ..To compare the magnitude and durability of the antiviral response to fosamprenavir (FPV) plus ritonavir (RTV) once-daily (FPV/r QD) with nelfinavir twice-daily (NFV BID), each administered with abacavir and lamivudine twice-daily...
  40. ncbi The urinary safety profile and secondary renal effects of retigabine (ezogabine): a first-in-class antiepileptic drug that targets KCNQ (K(v)7) potassium channels
    Neil Brickel
    GlaxoSmithKline, Stockley Park, Middlesex, UK
    Epilepsia 53:606-12. 2012
    ..The reported clinical effects of RTG/EZG are consistent with its documented effects on bladder smooth muscle in preclinical studies. RTG/EZG should be used with caution in patients at risk of urinary retention...
  41. pmc Sensitive and rapid method for amino acid quantitation in malaria biological samples using AccQ.Tag ultra performance liquid chromatography-electrospray ionization-MS/MS with multiple reaction monitoring
    Jenny M Armenta
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Anal Chem 82:548-58. 2010
    ..falciparum and human red blood cells samples. This study should provide a valuable insight into the performance of UPLC-ESI-MS/MS for amino acid quantitation using AccQ*Tag derivatization...
  42. ncbi Carbamylation differentially alters type I collagen sensitivity to various collagenases
    Stéphane Jaisson
    Laboratory of Biochemistry and Molecular Biology, CNRS UMR 6198, IFR53 Biomolecules, Faculty of Medicine, University of Reims Champagne Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France
    Matrix Biol 26:190-6. 2007
    ....
  43. ncbi Efficient hydrogenation of organic carbonates, carbamates and formates indicates alternative routes to methanol based on CO2 and CO
    Ekambaram Balaraman
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Nat Chem 3:609-14. 2011
    Catalytic hydrogenation of organic carbonates, carbamates and formates is of significant interest both conceptually and practically, because these compounds can be produced from CO2 and CO, and their mild hydrogenation can provide ..
  44. ncbi Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates
    Li Chen
    State Key Laboratory of Elemento organic Chemistry, Research Institute of Elemento organic Chemistry, Nankai University, Tianjin 300071, People s Republic of China
    J Agric Food Chem 55:2659-63. 2007
    New propesticides with two effects of both benzoylphenylureas and carbamates were designed and synthesized by the key intermediate N-chlorosulfenyl-N-methylcarbamate, which was prepared for the first time...
  45. ncbi Enhancement of endocannabinoid signalling during adolescence: Modulation of impulsivity and long-term consequences on metabolic brain parameters in early maternally deprived rats
    Eva Maria Marco
    Unit of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Roma, Italy
    Pharmacol Biochem Behav 86:334-45. 2007
    ..In summary, administration of URB597 during adolescence increased self-control behaviour and produced enduring brain biochemical modifications, in a model for neuropsychiatric disorders...
  46. pmc Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates
    Jae Won Chang
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Chem Biol 19:579-88. 2012
    ..The recent discovery of O-aryl carbamates such as JZL184 as selective MAGL inhibitors has enabled functional investigation of 2-AG signaling pathways in ..
  47. ncbi Multifunctional and highly sensitive precolumn reagents for amino acids in liquid chromatography/tandem mass spectrometry
    Kazutaka Shimbo
    Institute of Life Sciences, Ajinomoto Company, Incorporated, 1 1 Suzukicho Kawasaki ku, Kawasaki 210 8681 Japan
    Anal Chem 81:5172-9. 2009
    ....
  48. ncbi Review on the use of enzymes for the detection of organochlorine, organophosphate and carbamate pesticides in the environment
    J Susan Van Dyk
    Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6140, South Africa
    Chemosphere 82:291-307. 2011
    ..Three of the main classes of pesticides that pose a serious problem are organochlorines, organophosphates and carbamates. While pesticides are associated with many health effects, there is a lack of monitoring data on these ..
  49. ncbi Enhanced pesticide sensitivity of novel housefly acetylcholinesterases: a new tool for the detection of residual pesticide contamination
    Furong Tan
    Biotechnology Research Institute, Shanghai Academy of Agriculture Sciences, 2901 Beidi Road, Shanghai 201106, China
    Bioprocess Biosyst Eng 34:305-14. 2011
    ..The AChE enzyme obtained by this method could be used to detect the organophosphate and carbamate insecticide residues in fruits and vegetables, a characteristic of great potential research and industrial application...
  50. pmc One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders
    T A Jepps
    Division of Biomedical Sciences, St George s, University of London, Cranmer Terrace, UK
    Br J Pharmacol 168:19-27. 2013
    ..This review discusses the potential of targeting Kv7 channels in the smooth muscle to treat diseases such as hypertension, bladder instability, constipation and preterm labour...
  51. pmc Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation
    Sarah A Eisenstein
    Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, Georgia 30602 3013, USA
    Synapse 63:941-50. 2009
    ..Our data collectively suggest that the endocannabinoid system is compromised in olfactory bulbectomized rats...
  52. ncbi Time-course, dose-response, and age comparative sensitivity of N-methyl carbamates in rats
    Virginia C Moser
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 114:113-23. 2010
    ..To study potential age-related differences, we evaluated seven carbamates (carbaryl, carbofuran, formetanate, methiocarb, methomyl, oxamyl, and propoxur) in preweanling (17 days old or ..
  53. ncbi Oxime carbamate--discovery of a series of novel FAAH inhibitors
    S Y Sit
    Department of Chemistry, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492 7660, USA
    Bioorg Med Chem Lett 20:1272-7. 2010
    A series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (FAAH)...
  54. ncbi Differential gene expression analysis in Enchytraeus albidus exposed to natural and chemical stressors at different exposure periods
    Sara C Novais
    Department of Biology and CESAM, University of Aveiro, 3810 193 Aveiro, Portugal
    Ecotoxicology 21:213-24. 2012
    ..Some genes were differentially expressed in a stress specific manner and, in general, the responses were related with effects in the energy metabolism and cell growth...
  55. ncbi Randomized, double-blind, placebo-controlled study of XP13512/GSK1838262 in patients with RLS
    C A Kushida
    Stanford University Center of Excellence for Sleep Disorders, Stanford, CA 94305 5730, USA
    Neurology 72:439-46. 2009
    ..To assess the efficacy and tolerability of the nondopaminergic agent XP13512/GSK1838262 in adults with moderate to severe primary restless legs syndrome (RLS)...
  56. pmc Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
    G Gobbi
    Department of Psychiatry, McGill University, Montreal, QC, Canada H1N 3V2
    Proc Natl Acad Sci U S A 102:18620-5. 2005
    ..The findings support a role for anandamide in mood regulation and point to fatty-acid amide hydrolase as a previously uncharacterized target for antidepressant drugs...
  57. ncbi Development of a microarray for Enchytraeus albidus (Oligochaeta): preliminary tool with diverse applications
    Mónica J B Amorim
    CESAM and Department of Biology, University of Aveiro, Aveiro, Portugal
    Environ Toxicol Chem 30:1395-402. 2011
    ..albidus. It demonstrates the usefulness of cDNA normalization in the production of cDNA libraries of ecotoxicological standard organisms that are not genome models like E. albidus...
  58. ncbi Can avoidance in Enchytraeus albidus be used as a screening parameter for pesticides testing?
    Sara C Novais
    CESAM and Department of Biology, University of Aveiro, 3810193 Aveiro, Portugal
    Chemosphere 79:233-7. 2010
    ..From an ecological point of view, avoidance tests are relevant but due to lower sensitivity and higher variability it is recommended that the enchytraeid avoidance test should not be used for risk assessment purposes...
  59. ncbi Inhibition of microglial fatty acid amide hydrolase modulates LPS stimulated release of inflammatory mediators
    Chui Se Tham
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121 1126, United States
    FEBS Lett 581:2899-904. 2007
    ..Additional of supplemental exogenous anandamide did not increase the magnitude of attenuation of mediator release. The effect of URB597 on LPS stimulated PGE2 release was not blocked by selective CB1 or CB2 receptor antagonists...
  60. ncbi Transporters as a determinant of drug clearance and tissue distribution
    Yoshihisa Shitara
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1, Inohana, Chou ku, Chiba 260 8675, Japan
    Eur J Pharm Sci 27:425-46. 2006
    ..Double transfected cells, where both uptake and efflux transporters are expressed on the same polarized cells, are also helpful for the analysis of the rate of transporter-mediated transcellular transport...
  61. pmc Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity
    S Y M Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s, University of London, London, UK
    Br J Pharmacol 151:758-70. 2007
    ..This study represents a novel characterisation of KCNQ-encoded potassium channels in the vasculature using a variety of pharmacological and molecular tools to determine their role in contractility...
  62. pmc Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers
    Qiaojie Xiong
    Departments of Neuroscience, Physiology and High Throughput Biology Center, School of Medicine, Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:3128-33. 2008
    ..The resultant combinatorial potentiation by multiple synthetic chemical openers indicates that KCNQ channels are accessible to various types and combinations of pharmacological regulation...
  63. pmc Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents
    Sym Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s University of London, London, UK
    Br J Pharmacol 155:62-72. 2008
    ..This study investigated the functional and electrophysiological effects of the Kv7 channel activator, retigabine, on murine portal vein smooth muscle...
  64. ncbi Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat
    Andrea Cippitelli
    Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy
    Psychopharmacology (Berl) 198:449-60. 2008
    ..As an alternative approach, CB1-receptor-mediated activity can be facilitated by increasing anandamide levels with the use of hydrolase fatty acid amide hydrolase (FAAH) inhibitors...
  65. ncbi Retigabine reduces the excitability of unmyelinated peripheral human axons
    P M Lang
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, D 80336 Munich, Germany
    Neuropharmacology 54:1271-8. 2008
    ..It is likely that activation of these channels by retigabine may reduce the ectopic generation of action potentials in neuropathic pain...
  66. ncbi Treatment with amprenavir alone or amprenavir with zidovudine and lamivudine in adults with human immunodeficiency virus infection. AIDS Clinical Trials Group 347 Study Team
    R L Murphy
    Division of Infectious Diseases, Northwestern University Medical School, Illinois, Chicago, IL 60611, USA
    J Infect Dis 179:808-16. 1999
    ..04 log10 copies/mL, and 17 (63%) of 27 evaluable subjects had <500 HIV RNA copies/mL. Treatment with amprenavir, zidovudine, and lamivudine together reduced the levels of HIV RNA significantly more than did amprenavir monotherapy...
  67. ncbi Retigabine, the specific KCNQ channel opener, blocks ectopic discharges in axotomized sensory fibres
    Carolina Roza
    Dpto Fisiologia, Edificio de Medicina, Campus Universitario, Universidad de Alcala, Alcala de Henares, Madrid 28871, Spain
    Pain 138:537-45. 2008
    ..Results indicate that KCNQ channel opening at axotomized endings may constitute a novel and selective mechanism for modulation of some neuropathic pain symptoms...
  68. ncbi Laboratory toxicity test and post-exposure feeding inhibition using the giant freshwater prawn Macrobrachium rosenbergii
    Kriengkrai Satapornvanit
    Department of Fishery Biology, Faculty of Fisheries, Kasetsart University, Bangkhen, Chatuchak, Bangkok 10900, Thailand
    Chemosphere 74:1209-15. 2009
    ..This study demonstrated that the M. rosenbergii could also be used as a test animal to detect the effects of different chemical contaminants in aquatic environments...
  69. pmc The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition
    Jianxun Han
    Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2
    Breast Cancer Res 11:R57. 2009
    ....
  70. pmc Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy
    Hiroyuki Kashiwagi
    Department of Surgery, Washington University School of Medicine, Saint Louis, USA
    Mol Cancer 6:48. 2007
    ..The sigma-2 receptor has been found to be over-expressed in some types of malignant tumors, and, recently, small molecule ligands to the sigma-2 receptor were found to induce cancer cell apoptosis...
  71. ncbi A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice
    A Koumura
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 5858, Japan
    Neuroscience 157:309-18. 2008
    ..SNJ-1945 may therefore be a potential drug for stroke...
  72. ncbi Expression, localization, and pharmacological role of Kv7 potassium channels in skeletal muscle proliferation, differentiation, and survival after myotoxic insults
    Fabio Arturo Iannotti
    Division of Pharmacology, Department of Neuroscience, University of Naples Federico II, Naples, Italy
    J Pharmacol Exp Ther 332:811-20. 2010
    ..These data collectively highlight neural K(v)7 channels as significant pharmacological targets to regulate skeletal muscle proliferation, differentiation, and myotoxic effects of drugs...
  73. ncbi Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats
    Tomi Streng
    Department of Clinical and Experimental Pharmacology, Lund University Hospital, Lund, Sweden
    J Urol 172:2054-8. 2004
    ..Retigabine is a novel anticonvulsant drug that not only augments gamma-aminobutyric acid mechanisms, but also opens voltage gated K+ channels (KCNQ). In this study we investigated the effects of retigabine on detrusor activity in rats...
  74. ncbi Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesterase
    R N'Guessan
    Centre Pierre Richet, Institut National Santé Publique, Bouake, Cote d Ivoire, France
    Med Vet Entomol 17:19-25. 2003
    ..Our study demonstrates the need to monitor carbamate resistance among populations of the An. gambiae complex in Africa, to determine its spread and anticipate vector control failure if these insecticides are employed...
  75. ncbi Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration--comparison with CB(1) receptor blockade
    Benoit Forget
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health CAMH, Toronto, Canada, M5S 2S1
    Psychopharmacology (Berl) 205:613-24. 2009
    ..Therefore, there is a great need to develop alternative ways of modulating the cannabinoid system that will be better tolerated...
  76. ncbi The effect of repaglinide on insulin secretion and oxidative stress in type 2 diabetic patients
    Tsvetalina Tankova
    Clinical Center of Endocrinology, Medical University, Sofia, Bulgaria
    Diabetes Res Clin Pract 59:43-9. 2003
    ..This improvement in glycaemic control was accompanied by a beneficial effect on oxidative stress in diabetes mellitus...
  77. ncbi Expression and function of K(v)7 channels in murine myometrium throughout oestrous cycle
    Laura A McCallum
    King s College London, St Thomas Hospital Campus, UK
    Pflugers Arch 457:1111-20. 2009
    ..05), whereas retigabine (K(v)7 activator) significantly relaxed uterine tissues (p < 0.001). These data are the first to characterise KCNQ and KCNE gene expression in a cell type outside of neurons and the cardiovascular system...
  78. ncbi Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels
    C Rundfeldt
    Department of Pharmacology 1, Arzneimittelwerk Dresden GmbH, Corporate R and D, ASTA Medica Group, Radebeul, Germany
    Arzneimittelforschung 50:1063-70. 2000
    ..No significant interaction with NMDA induced currents was observed...
  79. pmc CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide
    Tanja Busk Bidstrup
    Clinical Pharmacology, University of Southern Denmark, Winsløwparken 19, 5000 Odense C, Denmark
    Br J Clin Pharmacol 56:305-14. 2003
    ....
  80. pmc Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics
    Anton I Rosenbaum
    Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
    J Med Chem 53:5281-9. 2010
    ..LAL can be specifically inhibited by a variety of 3,4-disubstituted thiadiazole carbamates. An efficient synthesis of the C(3) oxygenated/C(4) aminated analogues has been developed that furnishes the ..
  81. ncbi Biodegradation of carbendazim by a novel actinobacterium Rhodococcus jialingiae djl-6-2
    Zhichun Wang
    Key Laboratory for Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China
    Chemosphere 81:639-44. 2010
    ..The inoculation of strain djl-6-2 to MBC-contaminated soil resulted in a higher degradation rate than noninoculated soil, which indicated the potential of strain djl-6-2 in bioremediation of MBC polluted soil...
  82. ncbi Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels
    M Dabrowski
    University Laboratory of Physiology, Oxford, UK
    Diabetologia 44:747-56. 2001
    ..The fact that MgADP potentiated this effect in the case of the beta cell, but not cardiac, type of channel could help explain why the drug shows no adverse cardiovascular side-effects in vivo...
  83. ncbi Retigabine/Ezogabine, a KCNQ/K(V)7 channel opener: pharmacological and clinical data
    Gökce Orhan
    Abteilung Neurologie mit Schwerpunkt Epileptologie, Hertie Institut für Klinische Hirnforschung, Universitat Tubingen, Tubingen, Germany
    Expert Opin Pharmacother 13:1807-16. 2012
    ..Retigabine/Ezogabine (RTG) is a third-generation antiepileptic drug (AED) with a novel mechanism of action. It enhances the activity of voltage-gated K(V)7 potassium channels...
  84. ncbi Amino acid analysis of sub-picomolar amounts of proteins by precolumn fluorescence derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate
    Akiko Masuda
    Biomolecular Characterization Team, RIKEN Advanced Science Institute, Hirosawa, Wako, Japan
    Biosci Trends 5:231-8. 2011
    ..These results suggest that the current AAA method is potentially applicable for highly sensitive analysis as a complement to mass spectrometry-based proteomics...
  85. ncbi Combined pyrethroid and carbamate 'two-in-one' treated mosquito nets: field efficacy against pyrethroid-resistant Anopheles gambiae and Culex quinquefasciatus
    P Guillet
    Institut Pierre Richet, Bouake, C te d Ivoire
    Med Vet Entomol 15:105-12. 2001
    ..leading to factory production of wash-resistant insecticidal nets treated with complementary insecticides...
  86. ncbi Impaired biological activity of erythropoietin by cyanate carbamylation
    K C Mun
    Department of Biochemistry, Keimyung University School of Medicine, Taegu, South Korea
    Blood Purif 18:13-7. 2000
    ..Therefore, we studied the effect of cyanate carbamylation on the erythropoietic activity of erythropoietin (EPO) in a rodent model...
  87. ncbi Acetylcholinesterase engineering for detection of insecticide residues
    Yvan Boublik
    Laboratoire de Synthèse et Physicochimie des Molécules d Intérêt Biologique, UMR 5068, Universite Paul Sabatier, 31062 Toulouse, France
    Protein Eng 15:43-50. 2002
    ..AChE) to increase its sensitivity and its rate of phosphorylation or carbamoylation by organophosphates or carbamates. The mutants made by site-directed mutagenesis were expressed in baculovirus...
  88. pmc Model for high-throughput screening of multitarget drugs in chemical neurosciences: synthesis, assay, and theoretic study of rasagiline carbamates
    Nerea Alonso
    Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela USC, 15782, Santiago de Compostela, Spain
    ACS Chem Neurosci 4:1393-403. 2013
    ..Consequently, this model may become a promising auxiliary tool for the discovery of new drugs for the treatment of neurodegenerative diseases...
  89. ncbi Identification of multidrug resistant protein 1 of mouse leukemia P388 cells on a PVDF membrane using 6-aminoquinolyl-carbamyl (AQC)-amino acid analysis and World Wide Web (WWW)-accessible tools
    N Shindo
    Division of Biochemical Analysis, Juntendo University School of Medicine, Tokyo, Japan
    Anal Biochem 264:251-8. 1998
    ..A database search was carried out with bovine serum albumin as a calibration protein. MDR1 in P388/DOX was ranked first by both databases with high reliability (score 14 for ExPASy, distance 1.34 for EMBL)...
  90. ncbi In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist
    F W Birke
    Department of Pulmonary Research, Boehringer Ingelheim Pharma, KG D 55216 Ingelheim am Rhein, Germany
    J Pharmacol Exp Ther 297:458-66. 2001
    ..BIIL 284 is an unusually potent and long-acting orally active LTB(4) antagonist, and is therefore under clinical development as a novel anti-inflammatory principle...
  91. ncbi Novel poly(ethylene imine) biscarbamate conjugate as an efficient and nontoxic gene delivery system
    Songlin Xu
    School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
    J Control Release 130:64-8. 2008
    ..PEIC can also transfect MeWo cells with large genes such as the 125kb Varicella-Zoster viral gene (VZV) at high activity...
  92. ncbi The use of serial measurement of plasma cholinesterase in the management of acute poisoning with organophosphates and carbamates
    I M Abdullat
    Toxicology Laboratory, National Drug and Poison Information Center, Jordan University Hospital, The University of Jordan, Jordan
    Forensic Sci Int 162:126-30. 2006
    ..To evaluate the benefits of using serial measurements of plasma cholinesterase (butyrylcholinesterase, BuChE) activity in the management of cholinesterase inhibitor insecticidal poisoning...
  93. ncbi Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity
    Matthew W Martin
    Department of Chemistry Research and Discovery, Amgen Inc, One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, USA
    J Med Chem 49:4981-91. 2006
    ..the synthesis, structure-activity relationships, and pharmacological characterization of 2-aminopyrimidine carbamates, a new class of compounds with potent and selective inhibition of Lck...
  94. ncbi Effects of short-term therapy with different insulin secretagogues on glucose metabolism, lipid parameters and oxidative stress in newly diagnosed Type 2 Diabetes Mellitus
    Yan Li
    Department of Endocrinology and Metabology, Sun Yat Sen Memorial Hospital, Guangzhou, China
    Diabetes Res Clin Pract 88:42-7. 2010
    ..To compare effects of three different insulin secretagogues on early-phase insulin secretion, metabolism of glucose and lipids, and lipid peroxidation in newly diagnosed Type 2 Diabetes Mellitus (T2DM)...
  95. ncbi Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity
    Nawal Serradji
    Unité de Recherche Pharmacochimie Moléculaire et Systèmes Membranaires, Laboratoire de Pharmacochimie Moleculaire, Universite Paris 7 Denis Diderot, 2 place Jussieu, 75251 Paris Cedex 05, France
    J Med Chem 47:6410-9. 2004
    ..The transport parameter measured (K(in)) proves that 1a is able to cross this biological barrier, but a pharmacokinetic study reveals its weak bioavailability in rats...
  96. ncbi Consensus superiority of the pharmacophore-based alignment, over maximum common substructure (MCS): 3D-QSAR studies on carbamates as acetylcholinesterase inhibitors
    Shailendra S Chaudhaery
    Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, India 226001
    J Chem Inf Model 49:1590-601. 2009
    In view of the nonavailability of complete X-ray structure of carbamates cocrystallized with AChE enzyme, the 3D-QSAR model development based on cocrystallized conformer (CCBA) as well as docked conformer-based alignment (DCBA) is not ..
  97. ncbi Synthesis and application of isocyanates radiolabeled with carbon-11
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario, Canada
    Chemistry 17:259-64. 2011
    ..This is demonstrated by using the method to make [carbonyl-(11) C]-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate which is a novel radiotracer for PET imaging of fatty acid amide hydrolase...
  98. ncbi Occurrence of organophosphorus and carbamate pesticide residues in surface water samples from the Rangpur district of Bangladesh
    Alamgir Zaman Chowdhury
    Agrochemicals and Environmental Research Division, Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Ganakbari, Savar, G P O BOX 3787, Dhaka, 1349, Bangladesh
    Bull Environ Contam Toxicol 89:202-7. 2012
    ..544-0.895, 0.949-1.671 and 0-0.195 μg/L, respectively. This result indicates that the general public living in the area of Rangpur is at high risk of pesticide exposure from contaminated waters in the environment...
  99. ncbi Development of a multi-residue method for the determination of 18 carbamates in tobacco by high-performance liquid chromatography/positive electrospray ionisation tandem mass spectrometry
    B Mayer-Helm
    Gallaher Austria Tabak, R and D, Hasnerstrasse 127, 1160 Vienna, Austria
    Rapid Commun Mass Spectrom 20:529-36. 2006
    A multi-residue method for the determination of carbamates in tobacco was developed by high-performance liquid chromatography (HPLC) triple quadrupole mass spectrometry (MS)...
  100. ncbi Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists
    Maria Prat
    Almirall, R and D Centre, Laurea Miro 408 410, Sant Feliu de Llobregat, 08980 Barcelona, Spain
    Bioorg Med Chem Lett 21:3457-61. 2011
    Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M(3) muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction...
  101. ncbi M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals
    Maria Martire
    Institute of Pharmacology, School of Medicine, Catholic University of Sacred Heart, 00168 Rome, Italy
    J Neurosci 24:592-7. 2004
    ..These findings provide novel evidence for a major regulatory role of KCNQ2 K+ channel subunits in neurotransmitter release from rat hippocampal nerve endings...

Research Grants67

  1. Fetal Exposure to Environmental Toxicants and Child Outcome
    ENRIQUE MAPUA OSTREA; Fiscal Year: 2012
    ..much needed information on the longitudinal, adverse effects on the growth and neurodevelopment of children of carbamates and pyrethroids, which are now widely used...
  2. Genetic Variants of Human Carboxylesterase 1 Influence the Activation and Antivir
    John S Markowitz; Fiscal Year: 2012
    ..hCES1 plays a prominent role in the hydrolysis of numerous structurally diverse carboxylic acid esters, carbamates, thioesters, and amide compounds...
  3. Development of vector-specific, resistance-breaking insecticides to reduce malari
    Paul R Carlier; Fiscal Year: 2013
    ..Our specific aims are to 1)improve stability of An. gambiae AChE (AgAChE)-selective carbamates to oxidative detoxification;2)acquire 3D structural information on AgAChE to optimize inhibition potency and ..
  4. Validation of carbamate pesticide screen for VetLIRN network
    ROBERT HOWARD POPPENGA; Fiscal Year: 2013
    ..b>Carbamates are highly toxic insecticides, with current pesticide use registrations...
  5. Pesticide Exposures and Risk of Preterm Birth
    Gary M Shaw; Fiscal Year: 2013
    ..g., endocrine disruptors or developmental toxicants) and physiochemical groupings (e.g., carbamates, halogenated hydrocarbons, and arsenicals) of pesticides during pregnancy are associated with >100,000 women ..
  6. Novel Radiotracers for PET Imaging of Fatty Acid Amide Hydrolase (FAAH)
    ALAN ALEXANDER WILSON; Fiscal Year: 2013
    ..As a consequence, successful PET imaging of FAAH will require the radiolabelling of the carbamates and ureas in the carbonyl position...
  7. Pilot Scale Libraries Inspired by Natural Products
    JEFFREY AUBE; Fiscal Year: 2012
    ..Lewis acid promoted reactions of alkyl azides that afford complex ketones that are subsequently converted to carbamates, amines, indoles, or other heterocyclic products, (2) libraries based on a recently reported class of twisted ..
  8. Development of Carbamate Amination Methodology and Synthesis of Levofloxacin
    NOAH FREDERICK FINE NATHEL; Fiscal Year: 2013
    ..The specific aim for this proposal describes the development and utility of nickel-catalyzed aminations of aryl carbamates. The health significance of this methodology lies in the synthesis of biologically active natural products and ..
  9. Impact of Pesticide Exposure on Cognition in Children
    THOMAS PETROS; Fiscal Year: 2004
    ..studies have documented that exposure to cholinesterase-inhibiting pesticides such as organophosphates (OPS) and carbamates constitutes a major health problem...
  10. Validation of biomarkers of prenatal pesticides exposure
    Robin Whyatt; Fiscal Year: 2003
    ..a battery of biologic markers of prenatal exposure to organophosphates and other non-persistent pesticides (carbamates and pyrethroids)...
  11. MITOCHONDRIA, PESTICIDES, ISOQUINOLINES AND PARKINSON'S
    Howard Strahlendorf; Fiscal Year: 2001
    DESCRIPTION (Taken from the Investigator's Abstract) Environmental pesticides including organochlorines and carbamates act as potential risk factors for neurodegeneration of dopamine (DA)-containing neurons in Parkinson's Disease...
  12. Personal Monitor to Detect Exposure to Toxic Agents
    Hal Cantor; Fiscal Year: 2004
    ..drop of whole blood to determine the degree of exposure of an individual to organophosphate (OP) compounds or carbamates. This device will be amenable to mass screening of pesticide workers, persons in direct contact with OP ..
  13. PROTECTIVE EFFECTS OF GARLIC DERIVATIVES IN LUNG
    Poh Gek Forkert; Fiscal Year: 1999
    ..5) Determine potential inhibition of lung tumors formed from the carbamates by garlic constituents...
  14. Multiplexed Personal Monitoring of Airborne Toxins
    BHARAT ACHARYA; Fiscal Year: 2007
    ..technology for the quantitative and simultaneous detection of two different classes of semi-volatile pesticides (carbamates and organophosphates) and for the discrimination of specific compounds within each class of pesticide...
  15. ALKALOID SYNTHESIS BY MILD NITROGEN RADICAL METHODS
    Martin Newcomb; Fiscal Year: 1990
    ..cation radicals, respectively) generated in mild and controlled reactions from N-hydroxypyridine-2-thione carbamates will be studied. Methods for producing both mono- and dialkyl substituted nitrogen radicals will be developed...
  16. Amidoglycosylation Reactions of Glycal Metallanitrenes
    Christian Rojas; Fiscal Year: 2004
    ..Conditions will be optimized for conversion of glycal carbamates to the corresponding metalla acyl nitrenes, initiating nitrogen insertion into the electron-rich glycal alkene, ..
  17. SYNTHESIS OF POTENTIAL CNS ANTITUMOR PRODRUGS
    Gerald Zon; Fiscal Year: 1980
    The synthesis of triorganosilylated carbamates and phosphoramides bearing a nitrogen mustard functionality will be continued to provide new classes of potential CNS antitumor prodrugs...
  18. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  19. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  20. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  21. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  22. HETEROCYCLIC RING COMPOUNDS FOR ALKALOID SYNTHESIS
    Albert Padwa; Fiscal Year: 2007
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  23. SYNTHESIS OF FUSED HETEROCYCLIC COMPOUNDS
    Albert Padwa; Fiscal Year: 2002
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  24. Interactions in the Site of Acetylcholinesterase
    Terrone Rosenberry; Fiscal Year: 2005
    ..abstract_text> ..
  25. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2009
    ..Molecular modeling will allow the design of candidates for more active drugs. Candidates will be evaluated in the squalene synthase assay. Collaborations for the medicinal chemistry components of the project have been arranged. ..
  26. STRATEGIES AND METHODS IN SYNTHESIS OF NATURAL PRODUCTS
    KATHLYN PARKER; Fiscal Year: 2003
    ..During the period which corresponds to this proposal, we plan to apply our new methodology to the synthesis of deacetylravidomycin and kidamycin, representatives of the remaining two major classes. ..
  27. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..
  28. 3rd International Scientific Conference on Occupational and Environmental Health
    Matthew Keifer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  30. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  31. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  32. Community Health Intervention with Yakima Agricultural *
    Matthew Keifer; Fiscal Year: 2006
    ..abstract_text> ..
  33. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  34. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  35. NEW DEVELOPMENTS IN ORGANOCOPPER CHEMISTRY
    R Dieter; Fiscal Year: 2004
    ..The proposed synthetic routes to pyrrolidine aza sugars will develop the potential synthetic power of alpha-aminoalkylcuprate chemistry. ..
  36. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  37. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  38. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  39. A cell-based assay to measure HCV drug susceptibility
    Neil Parkin; Fiscal Year: 2004
    ....
  40. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  41. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2003
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  42. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2009
    ..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  43. PHARMACOLOGY OF NEUROTRANSMITTERS IN HAIR CELL ORGANS
    William F Sewell; Fiscal Year: 2010
    ..If so, then analysis and understanding of these phenomena in auditory neurons could ultimately lead to insight useful in understanding CNS transmission. ..
  44. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  45. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  46. Inhibitor of FtsZ Polymerization in M. tuberculosis
    Robert Reynolds; Fiscal Year: 2004
    ..Data from the biological screening and the EM structural studies will feed back into compound design in an interactive, iterative drug design cycle that critically focuses on antibacterial potency and selectivity. ..
  47. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2003
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  48. FLUOROUS METHODS FOR TRADITIONAL AND PARALLEL SYNTHESIS
    DENNIS CURRAN; Fiscal Year: 2003
    ..In short, the work will help to move the very young field of fluorous chemistry from infancy into childhood. ..
  49. 2004 Biophysical Discussion: Membrane Microdomains
    Kenneth Jacobson; Fiscal Year: 2004
    ..The format of the Biophysical Discussions is unique in its stress on discussion and prior preparation by the participants. ..
  50. ISOTOPIC PROBES OF ENZYME REACTION MECHANISMS
    FRANK RAUSHEL; Fiscal Year: 2005
    ..These investigations will complement concurrent efforts to direct the evolution of new and enhanced activities from present-day proteins. ..
  51. Prenatal Insecticide Exposures Among Urban Minorities
    Robin Whyatt; Fiscal Year: 2005
    ..prenatal exposure to the newer insecticides that are coming into use to replace the older organophosphates and carbamates that are being phased out. The proposed research is timely...
  52. A novel assay for measuring HIV-1 replication capacity
    Michael Bates; Fiscal Year: 2005
    ..We anticipate performing approximately 2500 replication capacity determinations over a three year period. ..
  53. Screen for Mycobacterium Tuberculosis (RMI)
    E White; Fiscal Year: 2005
    ..tuberculosis. 3) To study the effect of these novel inhibitors on the pantothenate pathway in M. smegmatis. 4) To co-crystallize these compounds with pantothenate synthetase to study their mode of binding ..
  54. Oleylethanolamide derivatives as anti-obesity agents
    Daniele Piomelli; Fiscal Year: 2005
    ....
  55. Role of Endocannabinoids in the Behavioral Consequences of Social Isolation
    Daniele Piomelli; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. THE ROLE OF SULFATIDES IN ALZHEIMER'S DISEASE
    Xianlin Han; Fiscal Year: 2008
    ..abstract_text> ..
  57. Lipodystrophy among HIV-infected patients
    Heidi Crane; Fiscal Year: 2008
    ..abstract_text> ..
  58. Mechanisms and Control of Urea Biosynthesis
    FRANK RAUSHEL; Fiscal Year: 2007
    ..abstract_text> ..
  59. Critical Research Issues in Essential Tremor
    Rodger Elble; Fiscal Year: 2005
    ..We believe that such conferences are the best way to build and maintain momentum and interest in ET research. ..
  60. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2007
    ..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..
  61. DERIVATIVES OF DEMETHYLPENCLOMEDINE:ANTICANCER AGENTS
    LEE MORGAN; Fiscal Year: 2003
    ..abstract_text> ..
  62. Clinical Development of 4-Hydroperoxyifosfamide
    LEE MORGAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  63. Camptothecin Analogs for Cancer Therapy
    LEE MORGAN; Fiscal Year: 2007
    ..Prior to the latter, DEKK-TEC proposes screening the analogs in a wide spectrum of tumor models to insure the best cancer applications for the products. [unreadable] [unreadable] [unreadable]..
  64. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  65. NUCLEOSIDE ANALOGS AS ANTICANCER COMPOUNDS
    Yung Chi Cheng; Fiscal Year: 2007
    ..It should yield novel information for understanding the biochemical determinants of the action of L-OddC, the biochemistry of the enzymes studied and possible novel use of L-OddC for the treatment of solid tumor. ..