polymethyl methacrylate

Summary

Summary: Polymerized methyl methacrylate monomers which are used as sheets, moulding, extrusion powders, surface coating resins, emulsion polymers, fibers, inks, and films (From International Labor Organization, 1983). This material is also used in tooth implants, bone cements, and hard corneal contact lenses.

Top Publications

  1. ncbi Ultra-high-modulus polyethylene ribbon as reinforcement for denture polymethyl methacrylate: a short communication
    P K Vallittu
    NIOM, Scandinavian Institute of Dental Materials, Haslum, Norway
    Dent Mater 13:381-2. 1997
  2. pmc Giant cell tumor of bone: risk factors for recurrence
    Frank M Klenke
    Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Orthop Relat Res 469:591-9. 2011
  3. pmc In vitro activities of daptomycin-, vancomycin-, and teicoplanin-loaded polymethylmethacrylate against methicillin-susceptible, methicillin-resistant, and vancomycin-intermediate strains of Staphylococcus aureus
    Yuhan Chang
    Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Antimicrob Agents Chemother 55:5480-4. 2011
  4. ncbi Biomechanical comparison of different techniques in primary spinal surgery in osteoporotic cadaveric lumbar vertebrae: expansive pedicle screw versus polymethylmethacrylate-augmented pedicle screw
    Da Liu
    Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, People s Republic of China
    Arch Orthop Trauma Surg 131:1227-32. 2011
  5. ncbi An intraoperatively moulded PMMA prostheses like spacer for two-stage revision of infected total knee arthroplasty
    Sandro Kohl
    Department of Orthopaedic Surgery, Inselspital, University of Bern, Switzerland
    Knee 18:464-9. 2011
  6. ncbi Intacs insertion with the femtosecond laser for the management of keratoconus: one-year results
    Aylin Ertan
    Kudret Eye Hospital, Ankara, Turkey
    J Cataract Refract Surg 32:2039-42. 2006
  7. ncbi Biomechanical study of pedicle screw fixation in severely osteoporotic bone
    Stephen D Cook
    Tulane University Health Sciences Center, Department of Orthopaedic Surgery, 1430 Tulane Avenue, SL 32, New Orleans, LA 70112, USA
    Spine J 4:402-8. 2004
  8. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001
  9. ncbi Mechanical and histological evaluation of a PMMA-based bone cement modified with gamma-methacryloxypropyltrimethoxysilane and calcium acetate
    Tadashi Tsukeoka
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Biomaterials 27:3897-903. 2006
  10. ncbi Primary pedicle screw augmentation in osteoporotic lumbar vertebrae: biomechanical analysis of pedicle fixation strength
    Daniel J Burval
    Cleveland Clinic Foundation, Cleveland Clinic Spine Institute, Cleveland, OH 44195, USA
    Spine (Phila Pa 1976) 32:1077-83. 2007

Detail Information

Publications301 found, 100 shown here

  1. ncbi Ultra-high-modulus polyethylene ribbon as reinforcement for denture polymethyl methacrylate: a short communication
    P K Vallittu
    NIOM, Scandinavian Institute of Dental Materials, Haslum, Norway
    Dent Mater 13:381-2. 1997
    ..The aim of this study was to determine the effect of polyethylene fiber ribbon on the transverse strength of denture base polymer...
  2. pmc Giant cell tumor of bone: risk factors for recurrence
    Frank M Klenke
    Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Orthop Relat Res 469:591-9. 2011
    ..However, the best treatment of these tumors and risk factors for recurrence remain controversial...
  3. pmc In vitro activities of daptomycin-, vancomycin-, and teicoplanin-loaded polymethylmethacrylate against methicillin-susceptible, methicillin-resistant, and vancomycin-intermediate strains of Staphylococcus aureus
    Yuhan Chang
    Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Antimicrob Agents Chemother 55:5480-4. 2011
    ..Regarding the choice of antibiotics for cement loading in the treatment of Staphylococcus aureus infection, teicoplanin was superior in terms of antibacterial effects...
  4. ncbi Biomechanical comparison of different techniques in primary spinal surgery in osteoporotic cadaveric lumbar vertebrae: expansive pedicle screw versus polymethylmethacrylate-augmented pedicle screw
    Da Liu
    Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, People s Republic of China
    Arch Orthop Trauma Surg 131:1227-32. 2011
    ..The purpose of this study was to compare the stability of EPS and PMMA-PS in primary spinal surgery...
  5. ncbi An intraoperatively moulded PMMA prostheses like spacer for two-stage revision of infected total knee arthroplasty
    Sandro Kohl
    Department of Orthopaedic Surgery, Inselspital, University of Bern, Switzerland
    Knee 18:464-9. 2011
    ..The use of this spacer is a time sparing, cheap and convenient option in 2-stage TKA revision...
  6. ncbi Intacs insertion with the femtosecond laser for the management of keratoconus: one-year results
    Aylin Ertan
    Kudret Eye Hospital, Ankara, Turkey
    J Cataract Refract Surg 32:2039-42. 2006
    ..To assess the outcomes of intrastromal ring segment (Intacs, Addition Technology) implantation for keratoconus using the femtosecond laser...
  7. ncbi Biomechanical study of pedicle screw fixation in severely osteoporotic bone
    Stephen D Cook
    Tulane University Health Sciences Center, Department of Orthopaedic Surgery, 1430 Tulane Avenue, SL 32, New Orleans, LA 70112, USA
    Spine J 4:402-8. 2004
    ..An expandable pedicle screw design has been shown to significantly improve fixation compared to a conventional screw in poor quality bone...
  8. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001
    ..Animal studies confirm their biocompatibility and osteoconductivity. However, handling problems and the limited radiopacity of these cements currently preclude their clinical use...
  9. ncbi Mechanical and histological evaluation of a PMMA-based bone cement modified with gamma-methacryloxypropyltrimethoxysilane and calcium acetate
    Tadashi Tsukeoka
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Biomaterials 27:3897-903. 2006
    ..The modification was found to be effective in enabling osteoconduction with PMMA bone cement, thus providing stable fixation for a long period after implantation...
  10. ncbi Primary pedicle screw augmentation in osteoporotic lumbar vertebrae: biomechanical analysis of pedicle fixation strength
    Daniel J Burval
    Cleveland Clinic Foundation, Cleveland Clinic Spine Institute, Cleveland, OH 44195, USA
    Spine (Phila Pa 1976) 32:1077-83. 2007
    ..Pedicle screw pullout testing in osteoporotic and control human cadaveric vertebrae, comparing augmented and control vertebrae...
  11. ncbi Biomechanical evaluation of vertebroplasty and kyphoplasty with polymethyl methacrylate or calcium phosphate cement under cyclic loading
    Hans Joachim Wilke
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Ulm, Germany
    Spine (Phila Pa 1976) 31:2934-41. 2006
    ..We developed a new method to simulating in vivo dynamic loading as closely as possible, which allows comparison of kyphoplasty and vertebroplasty, as well as augmentation materials...
  12. ncbi An evaluation of the surface changes in PMMA biomaterial formulations as a result of toothbrush/dentifrice abrasion
    R Richmond
    The University Dental Hospital of Manchester, Higher Cambridge Street, M15 6HF Manchester, UK
    Dent Mater 20:124-32. 2004
    ..A fourth group of specimens (prepared from Trevalon using the injection-molding procedure) was compared to the compression-molded specimens...
  13. ncbi Biomechanical analysis of different techniques in revision spinal instrumentation: larger diameter screws versus cement augmentation
    Dirk W Kiner
    Department of Orthopaedic Surgery, University of Tennessee College of Medicine, Chattanooga, TN 37415, USA
    Spine (Phila Pa 1976) 33:2618-22. 2008
    ..Biomechanical analysis...
  14. ncbi Anterior spinal column augmentation with injectable bone cements
    Jorrit Jan Verlaan
    Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Biomaterials 27:290-301. 2006
    ..b>Polymethyl methacrylate cement is the bone void filler that is used most frequently, although the application of calcium ..
  15. ncbi NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis
    John C Clohisy
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, One Barnes Jewish Hospital Plaza, Suite 11300, West Pavillion, St Louis, MO 63110, USA
    J Orthop Res 22:13-20. 2004
    ..Again, this inhibitor efficiently blocked particle-induced osteoclastogenesis. Thus, we have shown that pharmaceutical and molecular blockade of NF-kB activation inhibits PMMA particle-directed osteoclastogenesis in vitro...
  16. ncbi Clinical outcome in cranioplasty: critical review in long-term follow-up
    Andrea Moreira-Gonzalez
    Institute for Craniofacial and Reconstructive Surgery, Southfield, Michigan 48075, USA
    J Craniofac Surg 14:144-53. 2003
    ..If this is adopted, good results and a satisfactory outcome can be achieved on long-term follow-up...
  17. pmc Micro and nano MgO particles for the improvement of fracture toughness of bone-cement interfaces
    MORSHED KHANDAKER
    Department of Engineering and Physics, University of Central Oklahoma, Edmond, OK 73034, USA
    J Biomech 46:1035-9. 2013
    ..0001). Results indicated that the addition of the micro and nano MgO particles to PMMA improved the quality of bone-cement union...
  18. ncbi Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles
    Zhilong Shi
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge, Singapore 119260, Singapore
    Biomaterials 27:2440-9. 2006
    ..These results indicate a new promising strategy for combating joint implant infection...
  19. ncbi Water absorption of poly(methyl methacrylate) measured by vertical interference microscopy
    Mambaye N'diaye
    GEROM Groupe Etudes Remodelage Osseux et bioMatériaux LHEA, IRIS IBS Institut de Biologie en Santé, LUNAM Université, CHU d Angers, Angers, France
    Langmuir 28:11609-14. 2012
    ..Swelling parameters correlated with the nanoindentation data. PMMA can swell by absorbing a small amount of water and this induces a swelling that varies with the polymer composition and particle inclusions...
  20. pmc Asymptomatic diffuse pulmonary embolism caused by acrylic cement: an unusual complication of percutaneous vertebroplasty
    J Bernhard
    Department of Rheumatology and Clinical Immunology Allergology, University Hospital, CH 3010 Berne, Switzerland
    Ann Rheum Dis 62:85-6. 2003
  21. ncbi High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection
    Paloma Anguita-Alonso
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Orthop Relat Res 439:43-7. 2005
    ..The findings suggest that consideration should be given to the further study of agents other than aminoglycosides for incorporation into polymethylmethacrylate for the treatment and prevention of prosthetic joint infection...
  22. ncbi Percutaneous vertebroplasty for the treatment of burst fractures. Case report
    Jyi Feng Chen
    Department of Neurosurgery, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China
    J Neurosurg Spine 1:228-31. 2004
    ..The authors propose this procedure as a useful intervention in selected patients with lumbar burst fractures. The complications associated with major surgical procedures are absent...
  23. ncbi Effect of polymerization temperature and time on the residual monomer content of denture base polymers
    P K Vallittu
    Department of Prosthetic Dentistry, Institute of Dentistry, University of Turku, Finland
    Eur J Oral Sci 106:588-93. 1998
    ..The results of this study suggest that the polymerization temperature and polymerization time considerably affect the residual MMA content of denture base polymers...
  24. pmc Sensitivity of Candida albicans biofilm cells grown on denture acrylic to antifungal proteins and chlorhexidine
    Christopher R Pusateri
    Department of Restorative Dentistry, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Arch Oral Biol 54:588-94. 2009
    ..albicans biofilm cells compared to planktonic cells and measured whether surface treatment of denture acrylic with Hst 5, hBD-3, or chlorhexidine gluconate could inhibit in vitro biofilm development...
  25. ncbi Evaluation of calcium sulfate paste for augmentation of lumbar pedicle screw pullout strength
    Michael T Rohmiller
    Vanderbilt University, Department of Orthopedics and Rehabilitation, Vanderbilt University Spine Center, Nashville, TN, USA
    Spine J 2:255-60. 2002
    ..Calcium sulfate is an alternative to PMMA, because it lacks the exothermic reaction, is potentially osteoconductive and is resorbed by the body in 30 to 60 days...
  26. ncbi Long-term follow-up of intrastromal corneal ring segments in keratoconus
    Leonardo Torquetti
    Clinica de Olhos Paulo Ferrara, Avenida Contorno 4747, Sala 615, LifeCenter, Funcionários, Belo Horizonte, MG 30110 031, Brazil
    J Cataract Refract Surg 35:1768-73. 2009
    ..To report the long-term follow-up of Ferrara intrastromal corneal ring segment (ICRS) implantation for the management of keratoconus...
  27. pmc The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement
    Alyssa Ricker
    Divisions of Engineering and Orthopaedics, 184 Hope Street, Brown University, Providence, RI 02912, USA
    Int J Nanomedicine 3:125-32. 2008
    ..This study, thus, suggests that nanoparticles of MgO and BaSO4 should be further studied for improving properties of PMMA for orthopedic applications...
  28. ncbi One-year results of intrastromal corneal ring segment implantation (KeraRing) using femtosecond laser in patients with keratoconus
    Efekan Coskunseven
    Dunya Eye Hospital, Istanbul, Turkey
    Am J Ophthalmol 145:775-9. 2008
    ..To report the results of intrastromal corneal ring segment [ICRS] (KeraRing; Mediphacos, Belo Horizonte, Brazil) implantation using a femtosecond laser (IntraLase Corp, Irvine, California, USA) in keratoconic patients...
  29. ncbi Percutaneous vertebroplasty: indications, technique, and results
    Afshin Gangi
    Department of Radiology, University Louis Pasteur, Strasbourg, France
    Radiographics 23:e10. 2003
    ..The risk of leak is substantially reduced. The system is safe, reduces the cement manipulation time, and allows excellent control of the injection. The authors performed 130 vertebroplasties with this system without major complications...
  30. ncbi Daptomycin treatment of Staphylococcus aureus experimental chronic osteomyelitis
    Mark S Rouse
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Antimicrob Chemother 57:301-5. 2006
    ..Daptomycin is a cyclic lipopeptide anti-infective with activity against MRSA, approved for treatment of complicated skin and skin structure infections. Daptomycin may be useful in systemic or local treatment of chronic osteomyelitis...
  31. ncbi Polymethylmethacrylate augmentation of pedicle screw for osteoporotic spinal surgery: a novel technique
    Ming Chau Chang
    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Spine (Phila Pa 1976) 33:E317-24. 2008
    ..A retrospective study to evaluate the clinical results of patients with osteoporosis and various spinal diseases treated surgically with polymethylmethacrylate (PMMA) augmented pedicle screw...
  32. ncbi Staphylococcus aureus biofilm formation on different gentamicin-loaded polymethylmethacrylate bone cements
    H van de Belt
    Department of Orthopedic Surgery, University Hospital, Groningen, The Netherlands
    Biomaterials 22:1607-11. 2001
    ..Summarising, this study demonstrates that although gentamicin loading of bone cements yields reductions in biofilm formation, S. aureus is able to grow on gentamicin-loaded bone cements...
  33. ncbi Human histology and persistence of various injectable filler substances for soft tissue augmentation
    Gottfried Lemperle
    Division of Plastic Surgery, University of California, San Diego, CA, USA
    Aesthetic Plast Surg 27:354-66; discussion 367. 2003
    ..Since the mechanism of late inflammation or granuloma formation is still unknown, early histological findings are not useful in predicting possible late reactions to filler substances...
  34. ncbi Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy
    Wolfgang T Becker
    Orthopädische Klinik Volmarstein, Universitat Witten Herdecke, Wetter, Germany
    J Bone Joint Surg Am 90:1060-7. 2008
    ..The purpose of this study was to analyze the rates of recurrence following different types of treatment as well as the influence of various factors of tumor presentation on those rates...
  35. ncbi Posterior foraminotomy or anterior discectomy with polymethyl methacrylate interbody stabilization for cervical soft disc disease: results in 292 patients with monoradiculopathy
    Marcus C Korinth
    Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany
    Spine (Phila Pa 1976) 31:1207-14; discussion 1215-6. 2006
    Retrospective study of patients who underwent either ventral microdiscectomy and polymethyl methacrylate (PMMA) interbody stabilization or posterior foraminotomy for the treatment of cervical monoradiculopathy caused by soft disc disease.
  36. ncbi In vitro release of antibiotics from commercial PMMA beads and articulating hip spacers
    Dirk Jan F Moojen
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    J Arthroplasty 23:1152-6. 2008
    ..001). Despite the efficacy of high-dose antibiotic bone cement spacers, we believe one should be cautious toward using low-dose antibiotic bone cement for spacers because this could result in an unsuccessful eradication of infection...
  37. ncbi Vertebroplasty: clinical experience and follow-up results
    J B Martin
    Department of Neuroradiology, University Hospital HUG, University of Geneva, Switzerland
    Bone 25:11S-15S. 1999
    ..Control of PMMA volume seems to be the most critical point for avoiding complications. A good fluoroscopy control is therefore mandatory...
  38. ncbi Augmentation of pedicle screw fixation strength using an injectable calcium phosphate cement as a function of injection timing and method
    Susan M Renner
    Department of Bioengineering, The University of Illinois at Chicago, Chicago, Illinois, USA
    Spine (Phila Pa 1976) 29:E212-6. 2004
    ..Axial pullout tests using fresh cadaveric thoracolumbar vertebral bodies...
  39. ncbi Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts
    Y Yamanaka
    Department of Orthopaedics, Washington University School of Medicine, St Louis, Missouri, USA
    J Orthop Res 24:1349-57. 2006
    ..We have also found that polymethyl methacrylate (PMMA) particles stimulate osteoclastogenesis, at least in part, by induction of RANKL, TNF, and by ..
  40. ncbi Giant-cell tumor of the distal forearm
    Neil G Harness
    Orthopaedic Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hand Surg Am 29:188-93. 2004
    ..We have studied the results from our institution for 49 patients with giant-cell tumors of the distal forearm treated from 2 to 28 years (mean, 14 +/- 7 years) and compared the results for different methods of treatment...
  41. ncbi Biomechanical and morphological corneal response to placement of intrastromal corneal ring segments for keratoconus
    Caroline Dauwe
    Department of Ophthalmology, Reference National Centers for Keratoconus, Bordeaux University, France
    J Cataract Refract Surg 35:1761-7. 2009
    ..To evaluate the biomechanical and morphological changes in keratoconic corneas after Intacs intrastromal corneal ring segment (ICRS) implantation...
  42. ncbi Palamed G compared with Palacos R with gentamicin in Charnley total hip replacement. A randomised, radiostereometric study of 60 HIPS
    G Hallan
    Department of Orthopaedic Surgery, Haukeland University Hospital, University of Bergen, 5021 Bergen, Norway
    J Bone Joint Surg Br 88:1143-8. 2006
    ..No differences were found between the groups. Both bone cements provided good initial fixation of the femoral component and good clinical results at two years...
  43. ncbi Giant cell tumor of bone: treatment and outcome of 214 cases
    Maurice Balke
    Department of Orthopedic Surgery, University of Muenster, Muenster, Germany
    J Cancer Res Clin Oncol 134:969-78. 2008
    ..Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study...
  44. ncbi Comparative study of antimicrobial release kinetics from polymethylmethacrylate
    Paloma Anguita-Alonso
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Orthop Relat Res 445:239-44. 2006
    ..Cefazolin, ciprofloxacin, gatifloxacin, levofloxacin, linezolid, and rifampin may be suitable for incorporation into polymethylmethacrylate for management of orthopaedic infections...
  45. ncbi Percutaneous vertebroplasty in metastatic disease: transpedicular access and treatment of lysed pedicles--initial experience
    Jean Baptiste Martin
    Department of Radiology, Geneva University Hospital, Rue Micheli du Crest 24, CH 1211 Geneva 14, Switzerland
    Radiology 229:593-7. 2003
    ..In all cases, a radiologically satisfactory filling of both the affected pedicle and the vertebral body was achieved. Clinically effective pain relief was obtained in 24 (75%) of 32 patients, and no clinical complications were observed...
  46. ncbi Fabrication and characterization of poly(methylmethacrylate) microfluidic devices bonded using surface modifications and solvents
    Laurie Brown
    Department of Chemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Lab Chip 6:66-73. 2006
    ..The bond strength decreased with increasing surface hydrophilicity after solvent bonding, a trend that was opposite to what was observed for non-solvent thermal bonding...
  47. ncbi Enzyme-linked immunosorbent assay of Escherichia coli O157:H7 in surface enhanced poly(methyl methacrylate) microchannels
    Yunling Bai
    Department of Chemical and Biomolecular Engineering, The Ohio State University, 140 West 19th Avenue, Columbus, Ohio 43210, USA
    Biotechnol Bioeng 98:328-39. 2007
    ..With the high sensitivity, short assay time, and small reagent consumption, the microchannel ELISA can be economically used for fast detection of E. coli O157:H7...
  48. ncbi Long-term follow-up of Intacs in keratoconus
    George D Kymionis
    Department of Ophthalmology, Institute of Vision and Optics, University of Crete, Crete, Greece
    Am J Ophthalmol 143:236-244. 2007
    ..To evaluate long-term follow-up of Intacs microthin prescription inserts (Addition Technology, Inc, Fremont, California, USA) for the management of keratoconus...
  49. ncbi Electrophysiological recordings of single ion channels in planar lipid bilayers using a polymethyl methacrylate microfluidic chip
    Hiroaki Suzuki
    Institute of Industrial Science, The University of Tokyo, Meguro ku, Tokyo 153 8505, Japan
    Biosens Bioelectron 22:1111-5. 2007
    ..V., Noji, H., Takeuchi, S., 2006. Highly reproducible method of planar lipid bilayer reconstitution in polymethyl methacrylate microfluidic chip...
  50. ncbi Intacs for keratoconus
    Yaron S Rabinowitz
    Ophthalmology Research, Cornea Genetic Eye Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Curr Opin Ophthalmol 18:279-83. 2007
    ..The use of Intacs as a therapeutic modality in contact lens intolerant patients with mild to moderate keratoconus is increasingly gaining acceptance in the ophthalmic community...
  51. ncbi Tumor necrosis factor-alpha mediates polymethylmethacrylate particle-induced NF-kappaB activation in osteoclast precursor cells
    John C Clohisy
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
    J Orthop Res 20:174-81. 2002
    ..Thus, PMMA particle activation of NF-kappaB is a secondary event resulting from enhanced TNF expression and is independent of LPS contamination...
  52. pmc NFAT2 is an essential mediator of orthopedic particle-induced osteoclastogenesis
    Yasuhiro Yamanaka
    Department of Orthopedics, Washington University School of Medicine, One Barnes Hospital Plaza, 11300 West Pavilion, Campus Box 8233, St Louis, Missouri 63110, USA
    J Orthop Res 26:1577-84. 2008
    ..Thus, our findings demonstrate that activation of the NFAT pathway in conjunction with MAP kinases is essential for basal and PMMA-stimulated osteoclastogenesis...
  53. ncbi Efficacy of denture cleansers on Candida spp. biofilm formed on polyamide and polymethyl methacrylate resins
    Frederico Silva de Freitas Fernandes
    Department of Prosthodontics and Periodontology, Piracicaba Dental School, State University of Campinas, Piracicaba, Sao Paulo, Brazil
    J Prosthet Dent 105:51-8. 2011
    ..Although new materials have emerged as options to fabricate removable dental prostheses, the development of Candida biofilms on these materials and the effectiveness of methods to control these pathogenic biofilms are poorly understood...
  54. ncbi A mixed mode fracture toughness test of bone-biomaterial interfaces
    X Wang
    Mechanical Engineering, The University of Texas at San Antonio, 78249, USA
    J Biomed Mater Res 53:664-72. 2000
    ..It is expected that the mixed mode technique can provide an effective means for investigators to study the mechanical integrity of bone-biomaterial interfaces under complex loading conditions...
  55. ncbi Shear bond strength and failure types of polymethyl methacrylate denture base resin and titanium treated with surface conditioner
    Hyun Pil Lim
    Department of Prosthodontics, School of Dentistry, Chonnam National University, Bukgu, Gwangju, Korea
    Int J Prosthodont 23:246-8. 2010
    This study compared the shear bond strength and failure types of a polymethyl methacrylate (PMMA) denture base resin to commercially pure (CP) titanium, Ti-6Al-4V alloy, and cobalt-chromium alloy using a metal surface conditioner...
  56. ncbi Comparative effects of denture cleansers on physical properties of polyamide and polymethyl methacrylate base polymers
    Rukiye Durkan
    Department of Prosthodontics, Faculty of Dentistry, Afyon Kocatepe University, Afyon, Turkey
    Dent Mater J 32:367-75. 2013
    ..A significant decrease in hardness was observed for all resins except Rodex after immersion (p<0.05). The denture cleansers changed the roughness, hardness and color of some resins...
  57. ncbi Cranioplasty using polymethyl methacrylate prostheses
    Sai Cheung Lee
    Department of Neurosurgery, Chang Gung University, Taoyuan, Taiwan
    J Clin Neurosci 16:56-63. 2009
    In this retrospective study we attempted to assess the clinical performance of prefabricated polymethyl methacrylate (PMMA) prostheses and to determine whether they outperform intra-operatively moulded PMMA prostheses in reducing ..
  58. ncbi Evaluation of the abrasiveness of dentifrices for complete dentures
    Marina Xavier Pisani
    Department of Dental Materials and Prosthodontics, Ribeirao Preto Dental School, University of Sao Paulo, Ribeirao Preto, Brazil
    J Prosthodont 19:369-73. 2010
    ..This study analyzed the surface roughness and weight loss in Plex Glass specimens caused by dentifrices, one conventional (Sorriso) and three specific for dentures...
  59. ncbi Bone-cement interfacial behaviour under mixed mode loading conditions
    J Y Wang
    Mechanical Behaviour of Materials Laboratory, Department of Mechanical and Design Engineering, University of Portsmouth, UK
    J Mech Behav Biomed Mater 3:392-8. 2010
    ..The implications of the work on the studies of cemented joint replacements are also discussed...
  60. pmc Comparison of a new bisphenol-a-glycidyl dimethacrylate-based cortical bone void filler with polymethyl methacrylate
    E M Erbe
    Eur Spine J 10:S147-52. 2001
    ..was compared with Simplex P polymethyl methacrylate (Stryker Howmedica Osteonics, East Rutherford, N.J...
  61. ncbi Abrasiveness of conventional and specific denture-cleansing dentifrices
    Danilo Balero Sorgini
    Department of Dental Materials and Prosthodontics, Ribeirao Preto Dental School, University of Sao Paulo
    Braz Dent J 23:154-9. 2012
    ..In the other times, Sorriso, Colgate and Corega caused more surface roughness than DW. In conclusion, specific dentifrices caused larger mass loss and lower surface roughness as conventional dentifrice...
  62. ncbi The impact of facial lipoatrophy treatment with polymethyl methacrylate in AIDS patients as measured by four quality-of-life questionnaires
    M Warde
    Division of Plastic Surgery, Federal University of Sao Paulo, Sao Paulo, Brazil
    Int J STD AIDS 22:596-9. 2011
    ..We measured the impact of the treatment of facial lipoatrophy with polymethyl methacrylate (PMMA) in the QOL of patients with HIV/AIDS by using four questionnaires that address QOL...
  63. pmc The long-term in vivo behavior of polymethyl methacrylate bone cement in total hip arthroplasty
    Hiroyuki Oonishi
    H Oonishi Memorial Joint Replacement Institute, Tominaga Hospital, Osaka, Japan
    Acta Orthop 82:553-8. 2011
    ..However, there is concern about the durability of bone cement in vivo. We evaluated the physical and chemical properties of CMW1 bone cements retrieved from patients undergoing revision THA...
  64. pmc Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor
    Andre A Adams
    Department of Chemistry, Center for BioModular Multi Scale Systems, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Am Chem Soc 130:8633-41. 2008
    ..The simplicity in manufacturing the device and its ease of operation make it attractive for clinical applications requiring one-time use operation...
  65. ncbi Paradoxical cerebral arterial embolization of cement during intraoperative vertebroplasty: case report
    Rebecca Scroop
    Department of Neuroradiology, Flinders Medical Center, Flinders Drive, Bedford Park, SA, Australia
    AJNR Am J Neuroradiol 23:868-70. 2002
    ..Although this was an open procedure, the technical aspects were the same as for vertebroplasty and the precautions should be applied to percutaneous vertebroplasty...
  66. ncbi Treatment of thoracolumbar burst fractures with polymethyl methacrylate vertebroplasty and short-segment pedicle screw fixation
    Der Yang Cho
    Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan, Republic of China
    Neurosurgery 53:1354-60; discussion 1360-1. 2003
    We aimed to evaluate the efficacy of reinforcing short-segment pedicle screw fixation with polymethyl methacrylate (PMMA) vertebroplasty in patients with thoracolumbar burst fractures.
  67. ncbi A simplified technique for polymethyl methacrylate cranioplasty: combined cotton stacking and finger fracture method
    Woon Man Kung
    Department of Neurosurgery, Taipei City Hospital, Zhong Xiao Branch, Taipei, Taiwan
    Brain Inj 26:1737-42. 2012
    b>Polymethyl methacrylate (PMMA) is one of the most frequently used cranioplasty materials. However, limitations exist with PMMA cranioplasty including longer operative time, greater blood loss and a higher infection rate...
  68. ncbi Histologic changes after vertebroplasty
    J J Verlaan
    University Medical Center Utrecht, Utrecht, The Netherlands
    J Bone Joint Surg Am 86:1230-8. 2004
    ..Furthermore, we assessed whether a defect in the end plate, simulating end-plate fracture and allowing for direct contact of cement with disc tissue, had any effect on end-plate or disc degeneration...
  69. pmc Soft tissue extension increases the risk of local recurrence after curettage with adjuvants for giant-cell tumor of the long bones
    L van der Heijden
    Department of Orthopaedic Surgery, Leiden University Medical Center, The Netherlands
    Acta Orthop 83:401-5. 2012
    ..The aim of the study was the identification of individual risk factors after curettage with adjuvants in GCTB...
  70. ncbi [Optimized polymethyl methacrylate-embedding enables exact section examination of the femur with an uncemented femoral stem]
    F Martini
    Orthopädische Universitätsklinik und Poliklinik an der Eberhard Karls Universität, Tubingen, Germany
    Z Orthop Ihre Grenzgeb 139:531-5. 2001
    ..Thus, modifications with respect to the infiltration times in the individual solutions, the benzoyl peroxide quantities added and the temperature during the polymerization phase were undertaken...
  71. ncbi Intraocular lens factors that may affect anterior capsule contraction
    Ken Hayashi
    Hayashi Eye Hospital, Fukuoka, Japan
    Ophthalmology 112:286-92. 2005
    ..To examine the various factors comprising intraocular lenses (IOLs) that may affect the degree of anterior capsule contraction after cataract surgery...
  72. ncbi New bioactive glass-ceramic: synthesis and application in PMMA bone cement composites
    Hamizah Abd Samad
    School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Engineering Campus, Penang, Malaysia
    Biomed Mater Eng 21:247-58. 2011
    ..In contrast, dough time was observed to decrease with increased filler loading. Apatite morphology was observed on the surface of the glass-ceramic and selected cement after bioactivity test...
  73. ncbi The chemistry of acrylic bone cements and implications for clinical use in image-guided therapy
    David A Nussbaum
    Division of Interventional Neuroradiology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
    J Vasc Interv Radiol 15:121-6. 2004
    ..This information will allow interventional radiologists to manipulate bone cement characteristics for specific applications and maximize the clinical potential of image-guided interventions...
  74. pmc Antibiotic-releasing porous polymethylmethacrylate/gelatin/antibiotic constructs for craniofacial tissue engineering
    Meng Shi
    Department of Bioengineering, Rice University, TX, USA
    J Control Release 152:196-205. 2011
    ....
  75. ncbi Cytotoxicity of silica-glass fiber reinforced composites
    Gökçe Meriç
    Department of Prosthetic Dentistry, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway
    Dent Mater 24:1201-6. 2008
    ..The aim of this in vitro study was to determine the cytotoxicity of two polymers reinforced with two differently sized silica-glass fibers before and after thermal cycling. Cytotoxicity of the polymers without fibers was also evaluated...
  76. ncbi Release of dibenzoyl peroxide from polymethyl methacrylate denture base resins: an in vitro evaluation
    Arne F Boeckler
    Department of Prosthodontics, Martin Luther University Halle Wittenberg, Grosse Steinstrasse 19, 06108 Halle Saale, Germany
    Dent Mater 24:1602-7. 2008
    Dibenzoyl peroxide (BPO), an initiator in polymethyl methacrylate denture base resins, has been associated with allergic reactions in human patients...
  77. ncbi Theoretical prediction and experimental determination of the effect of mold characteristics on temperature and monomer conversion fraction profiles during polymerization of a PMMA-based bone cement
    Claudia I Vallo
    Institute of Materials Science and Technology INTEMA, Universidad Nacional de Mar del Plata National Research Council CONICET, Av Juan B Justo 4302 7600 Mar del Plata, Argentina
    J Biomed Mater Res 63:627-42. 2002
    ..The use of thin cement layers is recommended to diminish the risk of thermal injury; however, it is accompanied by an increase in the amount of unreacted monomer present in the cured material...
  78. ncbi Influence of polymerization conditions on monomer elution and microhardness of autopolymerized polymethyl methacrylate resin
    Shyh Yuan Lee
    Faculty of Dentistry, National Yang Ming University, Taipei, Taiwan
    Eur J Oral Sci 110:179-83. 2002
    ..The intent of this study was to systemically evaluate the effects of curing conditions on provisional polymethyl methacrylate (PMMA) resins which utilize a free-radical polymerization reaction...
  79. ncbi A bone substitute composed of polymethylmethacrylate and alpha-tricalcium phosphate: results in terms of osteoblast function and bone tissue formation
    Milena Fini
    Servizio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:4523-31. 2002
    ....
  80. pmc Cement leakage causes potential thermal injury in vertebroplasty
    Po Liang Lai
    Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan
    BMC Musculoskelet Disord 12:116. 2011
    ..However, the exothermic polymerization of bone cement may cause osseous or neural tissue injury. This study is thus designed to evaluate the potential risk of thermal damage in percutaneous vertebroplasty...
  81. pmc Outcome of in-the-bag implanted square-edge polymethyl methacrylate intraocular lenses with and without primary posterior capsulotomy in pediatric traumatic cataract
    Neelam Verma
    Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
    Indian J Ophthalmol 59:347-51. 2011
    To study the outcome of in-the-bag implanted square-edge polymethyl methacrylate (PMMA) intraocular lenses (IOL) with and without primary posterior capsulotomy in pediatric traumatic cataract.
  82. ncbi Extending polymerization time of polymethylmethacrylate cement in percutaneous vertebroplasty with ice bath cooling
    Ram Chavali
    Lahey Clinic Medical Center, Burlington, MA 01805, USA
    AJNR Am J Neuroradiol 24:545-6. 2003
    ..We have been using this technique since mid-1998, treating more than 600 vertebral bodies...
  83. ncbi Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models
    Paul M van Midwoud
    Pharmaceutical Analysis, Department of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Anal Chem 84:3938-44. 2012
    ..This paper lays an important foundation that will help researchers make informed decisions with respect to the materials they select for microfluidic cell-based culture experiments...
  84. ncbi The effect of temperature reduction on cement working time in percutaneous vertebroplasty
    S L J James
    Department of Radiology, Royal Orthopaedic Hospital, Birmingham, UK
    Clin Radiol 61:797-9. 2006
  85. ncbi Mechanical effects of the use of vancomycin and meropenem in acrylic bone cement
    Cecilia Persson
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli Bologna, IT 401 36 Italy
    Acta Orthop 77:617-21. 2006
    ..The antibiotics added to bone cements may, however, have detrimental effects on the mechanical properties of the cement...
  86. ncbi A new bioactive bone cement: effect of glass bead filler content on mechanical and biological properties
    S Shinzato
    Department of Orthopedic Surgery, Faculty of Medicine, Kyoto University, Japan
    J Biomed Mater Res 54:491-500. 2001
    ..We conclude that when mechanical properties and osteoconductivity are both taken into consideration, GBC60 is the most suitable formulation; it shows excellent osteoconductivity and sufficient mechanical strength for clinical use...
  87. ncbi NMP-modified PMMA bone cement with adapted mechanical and hardening properties for the use in cancellous bone augmentation
    Andreas Boger
    R and D Biomaterials, Synthes GmbH, 4436 Oberdorf, Switzerland
    J Biomed Mater Res B Appl Biomater 90:760-6. 2009
    ....
  88. ncbi The role of polymethylmethacrylate bone cement in modern orthopaedic surgery
    J C J Webb
    Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, UK
    J Bone Joint Surg Br 89:851-7. 2007
    ..The behaviour of antibiotic-loaded bone cement are discussed, together with areas of research that are now shedding light upon the behaviour of this unique biomaterial...
  89. ncbi Incorporation of chitosan in acrylic bone cement: effect on antibiotic release, bacterial biofilm formation and mechanical properties
    M M Tunney
    Clinical and Practice Research Group, School of Pharmacy, Queen s University, Belfast BT9 7BL, UK
    J Mater Sci Mater Med 19:1609-15. 2008
    ....
  90. ncbi PMMA-based bone cements containing magnetite particles for the hyperthermia of cancer
    M Kawashita
    Graduate School of Biomedical Engineering, Tohoku University, Sendai 980 8579, Japan
    Acta Biomater 6:3187-92. 2010
    ..The compressive strength of cement increased with increasing Fe(3)O(4) content. Cement with 50 wt.% Fe(3)O(4) particles generated heat in alternating magnetic fields of 300 and 120 Oe at a frequency of 100 kHz...
  91. ncbi Acute respiratory failure associated with polymethyl methacrylate pulmonary emboli after percutaneous vertebroplasty
    Matthew V Zaccheo
    Division of Hospitalist Medicine Pulmonary and Critical Care Medicine, Hamot Medical Center Erie, PA 16550, USA
    Am J Emerg Med 26:636.e5-7. 2008
    We report a case of symptomatic polymethyl methacrylate pulmonary emboli after percutaneous vertebroplasty to alert clinicians to this potential cause of pulmonary emboli...
  92. ncbi In vivo behavior of acrylic bone cement in total hip arthroplasty
    Michael D Ries
    University of California, 500 Parnassus Avenue MU 320 W, San Francisco, CA 94143, USA
    Biomaterials 27:256-61. 2006
    ..This implies that porosity is the most important factor in the mechanical behavior of bone cement during in vivo use...
  93. ncbi Increasing pedicle screw anchoring in the osteoporotic spine by cement injection through the implant. Technical note and report of three cases
    Patrick Fransen
    Brussels Neurosurgical Center, Brussels, Belgium
    J Neurosurg Spine 7:366-9. 2007
    ....
  94. ncbi The dynamic volume changes of polymerising polymethyl methacrylate bone cement
    Scott D Muller
    Department of Trauma and Orthopaedics, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Acta Orthop Scand 73:684-7. 2002
    ..Stable fixation of vacuum-mixed cement may depend on additional techniques to offset the altered volumetric behaviour of vacuum-mixed cement...
  95. ncbi The mechanical properties of recovered PMMA bone cement: a preliminary study
    R P S Chaplin
    Department of Engineering, University of Exeter, North Park Road, Exeter, EX4 4QF, UK
    J Mater Sci Mater Med 17:1433-48. 2006
    ..No evidence has been found to suggest that the PMMA has deteriorated whilst in-vivo and the mechanical properties of the cement matrices appear to be comparable to freshly made PMMA...
  96. ncbi Mechanical properties and osteoconductivity of new bioactive composites consisting of partially crystallized glass beads and poly(methyl methacrylate)
    Shuichi Shinzato
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kawahara cho 54, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomed Mater Res 60:556-63. 2002
    ..The new composites show promise as alternatives, with improved properties, to conventional PMMA bone cement...
  97. ncbi Augmentation of a loosened sacral pedicle screw with percutaneous polymethylmethacrylate injection
    Cem Yilmaz
    Department of Neurosurgeon, Baskent University, Ankara, Turkey
    J Spinal Disord Tech 19:373-5. 2006
    ..Case report describing augmentation of a loosened sacral screw with percutaneous injection of polymethylmethacrylate...
  98. ncbi Comparison of prevalence of microorganisms on titanium and silicone/polymethyl methacrylate obturators used for rehabilitation of maxillary defects
    Rita A Depprich
    Department of Cranio and Maxillofacial Surgery, Heinrich Heine University, Duesseldorf, Germany
    J Prosthet Dent 99:400-5. 2008
    Silicone or polymethyl methacrylate obturators, used for rehabilitation of maxillary defects, bear the risk of an enhanced settlement of microorganisms and, therefore, impose the risk of local or systemic infections...
  99. ncbi Repair of bone segment defects with surface porous fiber-reinforced polymethyl methacrylate (PMMA) composite prosthesis: histomorphometric incorporation model and characterization by SEM
    Mikko P Hautamäki
    Department of Prosthetic Dentistry and Biomaterials Science, Institute of Dentistry, University of Turku, Finland
    Acta Orthop 79:555-64. 2008
    ..We present an experimental study on segmental bone defect reconstruction using a polymethylmethacrylate-(PMMA-) based bulk polymer implant prosthesis. We concentrated on osteoconductivity and surface characteristics...
  100. ncbi In vivo temperature profile of intervertebral discs and vertebral endplates during vertebroplasty: an experimental study in sheep
    Nikolaus Aebli
    AO Spine Research Centre, Queensland University of Technology, Brisbane, Queensland, Australia
    Spine (Phila Pa 1976) 31:1674-8; discussion 1679. 2006
    ..Experimental study of temperature profiles during vertebroplasty...
  101. ncbi Vertebroplasty comparing injectable calcium phosphate cement compared with polymethylmethacrylate in a unique canine vertebral body large defect model
    Thomas M Turner
    Department of Orthopedic Surgery, Rush University Medical Center, 1725 Chicago, IL 60612, USA
    Spine J 8:482-7. 2008
    ..Calcium phosphate (CaP) offers the potential for biological resorption and replacement with new bone, restoring vertebral body mass and height...

Research Grants66

  1. Intralipid: A novel frontline countermeasure for brodifacoum poisoning
    Douglas L Feinstein; Fiscal Year: 2013
    ..We anticipate that LE will be proven to be an effective treatment for BDF poisoning, thereby providing a mechanism to address the potential damage due to a large scale release of BDF by either intentional or accidental causes. ..
  2. BEHAVIORAL MEDICINE RESEARCH IN CARDIOVASCULAR DISEASE
    Neil Schneiderman; Fiscal Year: 2013
    ..All trainees receive individual mentoring and participate in relevant program project and other research meetings. ..
  3. Protein, Enzyme, and Biological Water Dynamics: 2D Vibrational Echo Spectroscopy
    Michael D Fayer; Fiscal Year: 2011
    ..The methodology builds on previous successful applications and developments of state-of-the-art ultrafast infrared laser experiments. ..
  4. Hispanic Community Children's Health Study of Latino Youth SOL-Youth
    Krista M Perreira; Fiscal Year: 2013
    ..Findings from our study will inform practice and policy efforts to develop programs to prevent obesity in Latino youth and thus improve the health of future generations. ..
  5. Ancillary to HCHS/SOL: Sociocultural Factors and CVD risk/prevalence in Hispanics
    Frank J Penedo; Fiscal Year: 2010
    ..End of Abstract) ..
  6. NanoSPINs for In Vivo EPR-Based Spectroscopy and Imaging
    Valery V Khramtsov; Fiscal Year: 2010
    ....
  7. Signaling to and from the synapse
    Richard L Huganir; Fiscal Year: 2012
    ..Thus, understanding the mechanisms regulating the formation and modulation of synaptic transmission in the brain is critical for the development of treatments for these diseases. ..
  8. STEP UP In Health-related Research
    Raul DeLa Cadena; Fiscal Year: 2013
    ..The importance of the STEP UP in Health-related Research Program is to offer a rewarding experience to minority students to spark their interest in biomedical research careers. (End of Abstract) ..
  9. Epidemiologic Determinant of Cardiac Structure and Function Among Hispanics
    Carlos Jose Rodriguez; Fiscal Year: 2013
    ..ECHO-SOL will be extremely promising in learning about Hispanic cardiovascular health and highly relevant to future public health planning. ..
  10. Enabling high dose regional chemotherapy while minimizing systemic toxicity
    Shaker A Mousa; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The primary objective of this proposed study is to develop a novel Polymethyl methacrylate coated activated carbon filter with different compositions including cellulose and heparin for the ..
  11. Mechanisms of Defective Efferocytosis in Atherosclerosis
    IRA A TABAS; Fiscal Year: 2013
    ..Achieving the stated objective will provide critical information for understanding how necrotic cores form and may help in the design of new therapeutic strategies to prevent the clinical progression of atherosclerotic lesions. ..
  12. Hybrid Organic-Inorganic Composite Materials for Bone Repairs
    ADEREMI R OKI; Fiscal Year: 2012
    ..These lightweight composites are biocompatible and are able to stimulate bone mineral formation in body fluid. ..
  13. Plasticity at the Excitatory Synapse
    Richard L Huganir; Fiscal Year: 2013
    ..Understanding these basic mechanisms of synaptic transmission and plasticity will provide insight into normal and abnormal brain function. ..
  14. Production of Bioactive NO: Origin of Hemoglobin E Associated Pathophysiology
    RHODA HIRSCH; Fiscal Year: 2012
    ..There is the potential for a new paradigm in which to develop therapies for HbE [unreadable]-thalassemia. ..
  15. Training in Thrombosis, Hemostasis and Vascular Biology
    Satya P Kunapuli; Fiscal Year: 2012
    ..D., M.D., or D.V.M. degree. Each training program will depend on past research and educational : experience. State-of-the-art equipment and services are available within and outside of the Center. ..
  16. A Novel Biomimetic Bone Cement For Immediately Loaded Dental Implants
    DAVID ALLEN GAUL; Fiscal Year: 2010
    ..We expect that GEMOSIL's combination of mechanical properties and capability to be a scaffold for bone growth will allow patients to have a functioning tooth replacement in the same day as tooth extraction. ..
  17. Study of Latinos: Nutrition &Physical Activity Assessment Study (SOLNAS)
    Yasmin Mossavar-Rahmani; Fiscal Year: 2013
    ..The biomarker data from the proposed study will have the potential to calibrate nutrient and physical activity self-report data to increase reliability of disease association analyses. ..
  18. Hispanic Community Health Study
    Lisa Lavange; Fiscal Year: 2010
    ..Study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level. ..
  19. Hispanic Community Health Study
    Robert Kaplan; Fiscal Year: 2011
    ..Study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level. ..
  20. Hispanic Community Health Study
    MARTHA DIVIGLUS; Fiscal Year: 2012
    ..Study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level. ..
  21. Hispanic Community Health Study
    Gregory Talavera; Fiscal Year: 2012
    ..Study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level. ..
  22. Hispanic Community Health Study
    Gregory Talavera; Fiscal Year: 2013
    ..Study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level. ..
  23. Hispanic Community Health Study
    Neil Schneiderman; Fiscal Year: 2009
    ..Study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level. ..
  24. Hispanic Community Health Study
    Gregory Talavera; Fiscal Year: 2009
    ..Study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level. ..
  25. Developing a ClO2 Compliance Service: Minimizing Water Borne Microbial Infection
    SPENDEL U WOLFGANG; Fiscal Year: 2011
    ....
  26. Influence of surface adhesion forces on vocal fold stress and function
    Scott Thomson; Fiscal Year: 2009
    ..The objective of the proposed research is to develop models of the glottal ASL and explore its influence on vocal fold tissue stress and vibratory behavior. ..
  27. A New Approach to Autonomous Point-of-care Tropical Disease Diagnostics Using Sol
    David Erickson; Fiscal Year: 2013
    ..Our goal in this proposal is to develop the fundamental science behind solar-thermal microfluidic sample processing and demonstrate that it can be used to extract and concentrate cholera toxin B from a synthetic vomit sample. ..
  28. Polymer-Based Modular Systems with Nanosensors for DNA/RNA Sequencing
    Steven Allan Soper; Fiscal Year: 2012
    ....
  29. Compact Chemical Sensor for Measurement of Internal Dose of Environmental Agents
    RICHARD H CLARKE; Fiscal Year: 2010
    ..In this application, the drug or its metabolite might be monitored in a blood sample by SERS at regular intervals at home for compliance and adjustment of the medication, as required. ..
  30. Development of High Throughput Aptamer-based Protein Capture/Detection Assays tow
    John T Lis; Fiscal Year: 2013
    ..abstract_text> ..
  31. Analysis of Glutamate Receptor Function
    Andres Villu Maricq; Fiscal Year: 2013
    ..Thus, our research efforts might eventually contribute to the development of new diagnostic and therapeutic modalities for neurological disorders such as Alzheimer's disease, Parkinson's disease, and stroke. ..
  32. Low-Cost Microfluidic System for Detection of CTC's
    Mateusz Hupert; Fiscal Year: 2010
    ..The fluidic cartridge will possess a footprint the sue of a microscope slide. ..
  33. The Johns Hopkins Cancer Nanotechnology Training Center
    Denis Wirtz; Fiscal Year: 2013
    ..abstract_text> ..
  34. Validation of Objective Measures of Place-Based Physical Activity
    Kevin Patrick; Fiscal Year: 2012
    ....
  35. Rapid breath detection of colorectal cancer with a colorimetric sensor array
    RAY ANTHONY MARTINO; Fiscal Year: 2012
    ..A further application of this technology would be a breath test to non-invasively and inexpensively monitor the efficacy of chemotherapy treatment. ..
  36. Protein Reactivity in Sol-Gel Matrices: Hydration Effects in Confined Spaces
    Joel M Friedman; Fiscal Year: 2010
    ..Specific aims 2. Determine how confinement in the presence and absence of added osmolytes impacts functionally important categories of protein dynamics. . ..
  37. T-32 NIH Postdoctoral Training Program in Nanotechnology for Cancer Medicine NTCM
    Denis Wirtz; Fiscal Year: 2012
    ..The proposed postdoctoral training program will train fellows at the interface between nanotechnology and cancer medicine to develop novel nanoscale therapeutic and diagnostic tools for the detection, treatment and cure of human cancer ..
  38. Development of a Multilevel HIV Prevention for Latin American Men
    Susan M Kegeles; Fiscal Year: 2012
    ..If the intervention proves to be acceptable, feasible, and potentially efficacious, this research group will proceed with an R01 application to assess the efficacy of the intervention in a trial. ..
  39. INHIBITION OF UTERINE CONTRACTIONS BY FETAL MEMBRANES
    Patricia Collins; Fiscal Year: 1999
    ....
  40. RAPID BREATH DETECTION OF LUNG CANCER
    Paul Rhodes; Fiscal Year: 2012
    ..abstract_text> ..
  41. RAPID BREATH DETECTION OF LUNG CANCER
    Paul Rhodes; Fiscal Year: 2011
    ..abstract_text> ..
  42. INFLUENCE OF ACID-BASE STATUS ON FLUORIDE METABOLISM
    GARY WHITFORD; Fiscal Year: 1992
    ....
  43. BAND 3 N-TERMINAL AA (10-16) AND DEOXY S POLYMERIZATION
    John Harris; Fiscal Year: 1990
    ..A new class of inhibitors will be defined that may ultimately find applicability in controlling the intracellular polymerization basic to the pathophysiology and clinical manifestations of sickle cell disorders...
  44. Biomakers in Sickle Cell Anemia: Response to Hydroxyurea
    Marie Stuart; Fiscal Year: 2004
    ..In addition, findings from this study could have significant implications for other disease states associated with vasculopathy. ..
  45. Immune Tolerance Against Type I Diabetes in Mice
    Habib Zaghouani; Fiscal Year: 2007
    ..The NOD mouse, which develops spontaneous T1D, as well as mutant NOD strains, will be the animal model of choice for these investigations. ..
  46. MINIMIZING BLOOD TO EYE RATIO OF TOPICAL EYE MEDICATIONS
    Vincent Lee; Fiscal Year: 1992
    ....
  47. MOLECULAR BASIS FOR PLATELET FUNCTION IN HEMOSTASIS
    Robert Colman; Fiscal Year: 2004
    ..The knowledge gained from these studies will provide therapeutic approaches to enhancing hemostasis and preventing thrombosis. ..
  48. OTHER FUNCTIONS - R&D - HISPANIC COMMUNITY HEALTH STUDY
    JAIWEN CAI; Fiscal Year: 2012
    ..abstract_text> ..
  49. SOL-GEL DERIVED CONTINUOUS DUAL MATRIX COMPOSITES
    Robert Seghi; Fiscal Year: 1991
    ....
  50. Novel Cancer Nanotechnology Platforms for Photodynamic Therapy and Imaging
    Ravindra Pandey; Fiscal Year: 2009
    ..Paras Prasad, PhD (UB), will lead development and photophysical characterization of the Ormosil platform. Raoul Kopelman, PhD (UM), will lead development and photophysical characterization the polyacrylamide platform. ..
  51. SKELETAL MUSCLE MICROVASCULAR PERFUSION IN HYPERTENSION
    Sarah Gray; Fiscal Year: 1999
    ....
  52. CELLULAR INTERACTIONS OF PLASMA PROTEINS
    Peter Walsh; Fiscal Year: 2001
    ..The information gained from these studies will make possible the rational development of therapeutic interventions designed to treat hemorrhagic syndromes or to inhibit or prevent thrombogenesis in blood vessels. ..
  53. Novel Comprehensive Proteome Analyses of Metastasis
    David Speicher; Fiscal Year: 2001
    ..abstract_text> ..
  54. Novel Comprehensive Proteome Analyses of Metastasis
    David Speicher; Fiscal Year: 2004
    ..abstract_text> ..
  55. Novel F-releasing Nanocomposite Reinforced by Zirconia Nanofibers
    Xiaoming Xu; Fiscal Year: 2009
    ..These improved dental materials will reduce secondary caries and prolong the life of restorations. ..
  56. NEW HYDROGELS FOR GLUCOSE SENSING AND INSULIN DELIVERY
    Kinam Park; Fiscal Year: 2000
    ....
  57. Sol-Gel Synthesis of bioactive glass materials
    Aderemi Oki; Fiscal Year: 2003
    ..Zinc compound has also been shown to reveal a stimulatory effect on differentiation of osteoblastic cells. ..