methacrylates

Summary

Summary: Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group.

Top Publications

  1. ncbi Prostanoids as pharmacological targets in COPD and asthma
    Stephanie Rolin
    Department of Pharmacy, University of Namur, Rue de Bruxelles 61, B 5000 Namur, Belgium
    Eur J Pharmacol 533:89-100. 2006
  2. ncbi Nanoleakage, ultramorphological characteristics, and microtensile bond strengths of a new low-shrinkage composite to dentin after artificial aging
    Sillas Duarte
    Department of Comprehensive Care, Case Western Reserve University, School of Dental Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    Dent Mater 25:589-600. 2009
  3. ncbi Contraction stress of low-shrinkage composite materials assessed with different testing systems
    Giulio Marchesi
    Department of Biomedicine, Unit of Dental Sciences and Biomaterials, University of Trieste, Trieste, Italy
    Dent Mater 26:947-53. 2010
  4. ncbi Macro-, micro- and nano-mechanical investigations on silorane and methacrylate-based composites
    Nicoleta Ilie
    Department of Restorative Dentistry, Dental School of the Ludwig Maximilians University, Goethestr 70, 80336 Munich, Germany
    Dent Mater 25:810-9. 2009
  5. ncbi Effect of surface pre-treatment on durability of resin-based cements bonded to titanium
    Youhei Tsuchimoto
    Department of Oral and Maxillofacial Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
    Dent Mater 22:545-52. 2006
  6. ncbi Direct and indirect effects of the fungicide azoxystrobin in outdoor brackish water microcosms
    Kerstin Gustafsson
    School of Life Sciences, Södertörn University, Huddinge, Sweden
    Ecotoxicology 19:431-44. 2010
  7. ncbi Perspectives on the use of melatonin to reduce cytotoxic and genotoxic effects of methacrylate-based dental materials
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    J Pineal Res 51:157-62. 2011
  8. ncbi Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay
    Norbert H Kleinsasser
    Klinisch experimentelle Onkologie, Department of Otolaryngology Head and Neck Surgery, Ludwig Maximilians University Munich, Munich, Germany
    J Dent 32:229-34. 2004
  9. ncbi Induction of DNA double-strand breaks in primary gingival fibroblasts by exposure to dental resin composites
    Ebru Urcan
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstrasse 26, D 80336 Munich, Germany
    Biomaterials 31:2010-4. 2010
  10. ncbi Biocompatibility of resin-modified filling materials
    W Geurtsen
    Department of Conservative Dentistry and Periodontology, Medical University Hannover, Germany
    Crit Rev Oral Biol Med 11:333-55. 2000

Detail Information

Publications284 found, 100 shown here

  1. ncbi Prostanoids as pharmacological targets in COPD and asthma
    Stephanie Rolin
    Department of Pharmacy, University of Namur, Rue de Bruxelles 61, B 5000 Namur, Belgium
    Eur J Pharmacol 533:89-100. 2006
    ..This article aims to provide an overview of the role of prostanoids and isoprostanes in the pathogenesis of COPD and asthma and to discuss the pharmacological strategies developed in prevention and/or treatment of these pathologies...
  2. ncbi Nanoleakage, ultramorphological characteristics, and microtensile bond strengths of a new low-shrinkage composite to dentin after artificial aging
    Sillas Duarte
    Department of Comprehensive Care, Case Western Reserve University, School of Dental Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    Dent Mater 25:589-600. 2009
    ..The null hypotheses tested were (1) aging does not affect the bonding of low-shrinkage composite; (2) there is no difference in microtensile bond strengths and nanoleakage using different bonding strategies...
  3. ncbi Contraction stress of low-shrinkage composite materials assessed with different testing systems
    Giulio Marchesi
    Department of Biomedicine, Unit of Dental Sciences and Biomaterials, University of Trieste, Trieste, Italy
    Dent Mater 26:947-53. 2010
    ..It was hypothesized that the silorane-based material and the low-shrinkage nanohybrid composite would exhibit lower contraction stress than dimethacrylate-based composites irrespective of measuring system...
  4. ncbi Macro-, micro- and nano-mechanical investigations on silorane and methacrylate-based composites
    Nicoleta Ilie
    Department of Restorative Dentistry, Dental School of the Ludwig Maximilians University, Goethestr 70, 80336 Munich, Germany
    Dent Mater 25:810-9. 2009
    ....
  5. ncbi Effect of surface pre-treatment on durability of resin-based cements bonded to titanium
    Youhei Tsuchimoto
    Department of Oral and Maxillofacial Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
    Dent Mater 22:545-52. 2006
    ..Titanium has in recent years become a material of great opportunities in dentistry and orthopedics. In this study, we searched for a method to effectively pre-treat titanium as part of an adhesive luting and/or resin-veneering procedure...
  6. ncbi Direct and indirect effects of the fungicide azoxystrobin in outdoor brackish water microcosms
    Kerstin Gustafsson
    School of Life Sciences, Södertörn University, Huddinge, Sweden
    Ecotoxicology 19:431-44. 2010
    ....
  7. ncbi Perspectives on the use of melatonin to reduce cytotoxic and genotoxic effects of methacrylate-based dental materials
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    J Pineal Res 51:157-62. 2011
    ..This opens a new possible application of melatonin to improve properties of biomaterials used in dentistry...
  8. ncbi Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay
    Norbert H Kleinsasser
    Klinisch experimentelle Onkologie, Department of Otolaryngology Head and Neck Surgery, Ludwig Maximilians University Munich, Munich, Germany
    J Dent 32:229-34. 2004
    ..Whereas the cytotoxic potential of some components has been clearly documented, possible genotoxicity in human target cells demands further investigation...
  9. ncbi Induction of DNA double-strand breaks in primary gingival fibroblasts by exposure to dental resin composites
    Ebru Urcan
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstrasse 26, D 80336 Munich, Germany
    Biomaterials 31:2010-4. 2010
    ..25 and 0.5gamma-H2AX foci/HGF cell. Our results for the first time show that exposure to dental resin monomers can induce DSBs in primary human oral cavity cells, which underscores their genotoxic capacity...
  10. ncbi Biocompatibility of resin-modified filling materials
    W Geurtsen
    Department of Conservative Dentistry and Periodontology, Medical University Hannover, Germany
    Crit Rev Oral Biol Med 11:333-55. 2000
    ..Therefore, it is critical, both for our patients and for the profession, that the biological effects of resin-based filling materials be clarified in the near future...
  11. ncbi Effect of C-factor on microtensile bond strengths of low-shrinkage composites
    N A El-Sahn
    Department of Operative Dentistry, Cairo University, Cairo, Egypt
    Oper Dent 36:281-92. 2011
    ..Filtek Z250/Adper Single Bond Plus (Z, 3M ESPE, St Paul, MN, USA) was used as a control...
  12. ncbi Effect of wet vs. dry testing on the mechanical properties of hydrophilic self-etching primer polymers
    Keiichi Hosaka
    Cariology and Operative Dentistry, Department of Restorative Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Oral Sci 115:239-45. 2007
    ..Both E and UTS correlated significantly with the BisGMA concentration of the polymers, either wet or dry. The percentage changes in E or UTS were significantly correlated with the water sorption of the polymers...
  13. ncbi Identification of glutathione-methacrylates adducts in gingival fibroblasts and erythrocytes by HPLC-MS and capillary electrophoresis
    Giuseppina Nocca
    Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy
    Dent Mater 27:e87-98. 2011
    ..GSH can detoxify methacrylates by conjugating their α,β-unsaturated carbon-carbon moiety to the thiol group, with the catalysis of ..
  14. pmc Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair
    Janusz Blasiak
    Department of Molecular Genetics, University of Lodz, Pomorska 141 143, 90 236 Lodz, Poland
    Mol Biol Rep 39:7487-96. 2012
    ..while sodium ascorbate or melatonin improved the efficacy of H(2)O(2)-induced damage in the presence of the methacrylates. The adhesive induced a rise in the G2/M cell population, accompanied by a reduction in the S cell population ..
  15. ncbi The influence of short and medium-term water immersion on the hydrolytic stability of novel low-shrink dental composites
    W M Palin
    Biomaterials Unit, School of Dentistry, University of Birmingham, St Chad s Queensway, Birmingham B4 6NN, UK
    Dent Mater 21:852-63. 2005
    ....
  16. ncbi Influence of polymer architecture and molecular weight of poly(2-(dimethylamino)ethyl methacrylate) polycations on transfection efficiency and cell viability in gene delivery
    Christopher V Synatschke
    Makromolekulare Chemie II und Bayreuther Zentrum für Kolloide und Grenzflächen, Universitat Bayreuth, Bayreuth, Germany
    Biomacromolecules 12:4247-55. 2011
    ....
  17. ncbi N-acetyl cysteine directed detoxification of 2-hydroxyethyl methacrylate by adduct formation
    Giuseppina Nocca
    Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy
    Biomaterials 31:2508-16. 2010
    ..Moreover, we provide evidence that the actual intracellular concentration of HEMA able to cause cytotoxic effects is at least one magnitude lower than that applied extracellularly...
  18. pmc Enzymatic biodegradation of HEMA/bisGMA adhesives formulated with different water content
    Elisabet L Kostoryz
    Pharmacology and Toxicology Division, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, USA
    J Biomed Mater Res B Appl Biomater 88:394-401. 2009
    ....
  19. ncbi Influence of resin monomers on growth of oral streptococci
    Y Takahashi
    Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Dent Res 83:302-6. 2004
    ....
  20. ncbi Cytotoxicity and genotoxicity of glycidyl methacrylate
    Tomasz Poplawski
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Chem Biol Interact 180:69-78. 2009
    b>Methacrylates are used in the polymer form as composite restorative materials in dentistry...
  21. ncbi A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs
    Yoichi Ishitsuka
    Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
    J Pharmacol Sci 111:211-5. 2009
    ..Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury...
  22. ncbi Cytotoxicity of the dental composite component TEGDMA and selected metabolic by-products in human pulmonary cells
    Judith Emmler
    Bundeswehr Institute of Pharmacology and Toxicology, 80937 Munich, Germany
    Dent Mater 24:1670-5. 2008
    ..Metabolic by-products formerly associated with TEGDMA-degradation include triethylene glycol (TEG), methacrylic acid (MA), 2,3-epoxymethacrylic acid (2,3-EMA), and formaldehyde...
  23. ncbi Effect of 2-hydroxyethyl methacrylate on human pulp cell survival pathways ERK and AKT
    Gianrico Spagnuolo
    Department of Oral and Maxillofacial Sciences and Interdisciplinary Research Centre on Biomaterials CRIB, University of Naples Federico II, Naples, Italy
    J Endod 34:684-8. 2008
    ..Our findings demonstrated that HEMA exposure modulates the ERK and AKT pathways in different manners, and that in turn, they function in parallel to mediate pro-survival signaling in pulp cells subjected to HEMA cytotoxicity...
  24. ncbi Quantum-chemical descriptors for estimating hemolytic activity of aliphatic and aromatic methacrylates
    Mariko Ishihara
    Division of Chemistry, Meikai University School of Dentistry, 1 1 Keyakidai, Sakado, Saitama 350 0283, Japan
    Chemosphere 70:1898-902. 2008
    b>Methacrylates such as methyl methacrylate (6), triethyleneglycol dimethacrylate (5) and bisphenol A glycidyldimethacrylate, bis-GMA, (8) are widely used as materials in dental resins perturbation of the phosphatidylcholine-cholesterol ..
  25. ncbi Push-out strength of translucent fibre posts cemented using a dual-curing technique or a light-curing self-adhering material
    L Giachetti
    Dental Materials and Restorative Dentistry, Tuscany School of Dental Medicine, University of Florence and Siena, Department of Public Health, Dentistry, University of Florence, Italy
    Int Endod J 45:249-56. 2012
    ..To compare by means of a push-out test the interfacial strength of a dual-curing resin cement and a light-curing self-adhering resin composite when used in translucent fibre post cementation...
  26. ncbi Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay
    Norbert H Kleinsasser
    Ecogenotoxicology, Department of Otolaryngology Head and Neck Surgery, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Biomaterials 27:1762-70. 2006
    ..In the present study, genotoxic and cytotoxic effects of three common methacrylates are investigated in human samples of salivary glands and peripheral lymphocytes...
  27. ncbi Metabolism of TEGDMA and HEMA in human cells
    Jürgen Durner
    Institute of Clinical Chemistry, Ludwig Maximilians University of Munich, Germany
    Biomaterials 31:818-23. 2010
    ..Therefore the epoxide pathway with formation of the epoxy-intermediate 2,3-epoxymethacrylic acid is the main route of metabolisation of HEMA and TEGDMA...
  28. ncbi Conditioning effect on dentin, resin tags and hybrid layer of different acidity self-etch adhesives applied to thick and thin smear layer
    Silvia Kenshima
    University of Sao Paulo, FOUSP, Dental Materials Department, Av Professor Lineu Prestes, 2227, Cidade Universitaria, CEP 05508 000, Sao Paulo, SP, Brazil
    J Dent 34:775-83. 2006
    ..to assess the conditioning effect (CE) of self-etch adhesives of different acidity applied to thick and thin smear layer (SL), the corresponding resin tags (RT) and hybrid layer (HL)...
  29. ncbi Microtensile bond strength and interfacial characterization of 11 contemporary adhesives bonded to bur-cut dentin
    Mouhamed Sarr
    Universite Cheikh Anta Diop, Faculte de Medecine, Pharmacie et Odontologie, Dakar, Senegal
    Oper Dent 35:94-104. 2010
    ..This study evaluated mechanically and ultra-morphologically 11 different adhesive systems bonded to dentin...
  30. ncbi Infrared spectroscopy: a tool for determination of the degree of conversion in dental composites
    Luciene Gonçalves Palmeira Moraes
    Department of Physics and Chemistry, Sao Paulo State University, Ilha Solteira, SP, Brazil
    J Appl Oral Sci 16:145-9. 2008
    ..This paper presents important details to use infrared spectroscopy for determination of the conversion degree...
  31. ncbi Disruption of the alternative oxidase gene in Magnaporthe grisea and its impact on host infection
    Cruz Avila-Adame
    Department of Plant Pathology, Cornell University, New York State Agricultural Experiment Station, Geneva 14456, USA
    Mol Plant Microbe Interact 15:493-500. 2002
    ..Rather, alternative respiration provided protection from azoxystrobin during both saprophytic and infectious stages of the pathogen. The nature of similar oxidative stress conditions in the ecology of M. grisea remains an open question...
  32. ncbi Influence of fatigue loading on four post-and-core systems in maxillary premolars
    Peter Bolhuis
    Department of Dental Materials Science, ACTA, Amsterdam, The Netherlands
    Quintessence Int 35:657-67. 2004
    ..As the stiffness of posts may affect the outcome, post-and-core systems with varying post stiffness were selected...
  33. ncbi Physical properties of a new silorane-based restorative system
    Wen Lien
    Advanced Education in General Dentistry Residency, Wilford Hall Medical Center, Lackland AFB, TX 78236, USA
    Dent Mater 26:337-44. 2010
    ..To distinguish the physical properties of a new silorane-based restorative material in comparison to five methacrylate-based restorative materials--a compomer, giomer, nanocomposite, hybrid and micro-hybrid...
  34. ncbi Siloranes in dental composites
    Wolfgang Weinmann
    3M ESPE, Seefeld, Germany
    Dent Mater 21:68-74. 2005
    ..The purpose of this study was to compare the product profile of a Silorane based composite which polymerizes by a cationic ring opening process with the product profile of different methacrylate based restoratives...
  35. ncbi Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient
    Jürgen Durner
    Institute of Clinical Chemistry, Faculty of Medicine, Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Dent Mater 26:91-9. 2010
    ..The study was performed to investigate the elution of substances from unpolymerized and polymerized composites (Tetric=TET; Arabesk=ARA), ormoceres (Admira)=ADM; Definite=DEF) and the compomere (Hytac=HYT)...
  36. ncbi Antibacterial activity and bonding characteristics of an adhesive resin containing antibacterial monomer MDPB
    Satoshi Imazato
    Department of Restorative Dentistry and Endodontology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Dent Mater 19:313-9. 2003
    ....
  37. ncbi Effects of HEMA on type I collagen protein in human gingival fibroblasts
    M Falconi
    Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell Apparato Locomotore, Universita di Bologna, Italy
    Cell Biol Toxicol 23:313-22. 2007
    ..From these results, we conclude that low concentrations of HEMA can significantly alter the morphology of human gingival fibroblasts and interfere with the presence of type I collagen protein...
  38. ncbi Induction of DNA strand breaks by dental composite components compared to X-ray exposure in human gingival fibroblasts
    Jürgen Durner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestrasse 70, 80336 Munich, Germany
    Arch Toxicol 85:143-8. 2011
    ..But 0.25 mM BisGMA is more than 100-fold higher than that concentration found in worst case calculations. Therefore, our data did not support our hypothesis...
  39. ncbi Immediate repair bond strengths of microhybrid, nanohybrid and nanofilled composites after different surface treatments
    Margareta Rinastiti
    Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    J Dent 38:29-38. 2010
    ..To evaluate immediate repair bond strengths and failure types of resin composites with and without surface conditioning and characterize the interacting composite surfaces by their surface composition and roughness...
  40. ncbi Combination of integrin-binding peptide and growth factor promotes cell adhesion on electron-beam-fabricated patterns
    Christopher M Kolodziej
    Department of Chemistry and Biochemistry and the California NanoSystems Institute, University of California, Los Angeles, 607 Charles E Young Drive South, Los Angeles, California 90095, USA
    J Am Chem Soc 134:247-55. 2012
    ..The results also suggest positive implications for addition of growth factors into adhesive patterns for cell-material interactions...
  41. ncbi Influence of oxygen inhibition on the surface free energy and enamel bond strength of self-etch adhesives
    Koji Oyama
    Department of Operative Dentistry, Nihon University School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Dent Mater J 31:26-31. 2012
    ..The enamel bond strengths of the self-etch adhesives were significantly lower in the specimens without an oxygen-inhibited layer. The oxygen-inhibited layer therefore appeared to promote higher enamel bond strength...
  42. pmc Nanoscale growth factor patterns by immobilization on a heparin-mimicking polymer
    Karen L Christman
    Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E Young Drive East, Los Angeles, California 90095 1569, USA
    J Am Chem Soc 130:16585-91. 2008
    ..Fluorescence microscopy confirmed that bFGF and VEGF were subsequently immobilized to the polymer micro- and nanopatterns...
  43. ncbi Effect of composition, viscosity and thickness of the opaquer on the adhesion of resin composite to titanium
    Mutlu Ozcan
    University of Zurich, Dental Materials Unit, Center for Dental and Oral Medicine, Clinic for Fixed and Removable Prosthodontics and Dental Materials Science, Plattenstrasse 11, CH 8032, Zurich, Switzerland
    Dent Mater 25:1248-55. 2009
    ....
  44. ncbi Redox-cleavable star cationic PDMAEMA by arm-first approach of ATRP as a nonviral vector for gene delivery
    Fengying Dai
    School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, PR China
    Biomaterials 31:559-69. 2010
    ..The effect of medium pH on the star PDMAEMA system was smaller owing to the ability of densely tertiary amino groups along multiple arms to absorb more protons, which was favorable for endosomolytic escape of complexes...
  45. ncbi Dual-responsive magnetic core-shell nanoparticles for nonviral gene delivery and cell separation
    Alexander P Majewski
    Makromolekulare Chemie II, Universitat Bayreuth, 95440 Bayreuth, Germany
    Biomacromolecules 13:857-66. 2012
    ..Moreover, after transfection with the hybrid nanoparticles, the cells acquired magnetic properties that could be used for selective isolation of transfected cells...
  46. ncbi Ternary complexes of amphiphilic polycaprolactone-graft-poly (N,N-dimethylaminoethyl methacrylate), DNA and polyglutamic acid-graft-poly(ethylene glycol) for gene delivery
    Shutao Guo
    Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    Biomaterials 32:4283-92. 2011
    ....
  47. pmc Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemical and cell interaction properties of the polymer-DNA complexes
    Rahul Sharma
    School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    Biomacromolecules 9:3294-307. 2008
    ..Between the micelleplexes and the PEG-PDMAEMA polyplexes, a higher gene transfection efficiency is observed with the latter system. All three formulations show comparable levels of cytotoxicity in HeLa cells...
  48. pmc Evaluating resin-enamel bonds by microshear and microtensile bond strength tests: effects of composite resin
    Andrea Mello de Andrade
    Dental School, Department of Dental Materials, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Appl Oral Sci 18:591-8. 2010
    ....
  49. ncbi Comparison of silorane and methacrylate-based composite resins on the curing light transmission
    Ricardo Danil Guiraldo
    Department of Restorative Dentistry, School of Dentistry, University of North Parana, Londrina, PR, Brazil
    Braz Dent J 21:538-42. 2010
    ..The DKH of Filtek P90 (25%) was significantly higher than that of Heliomolar (12%). There was a greater degree of subsurface polymerization of the methacrylate-based composite compared to the silorane-based composite...
  50. ncbi Bond strength of adhesive systems to human tooth enamel
    Thais Cachute Paradella
    Department of Bioscience and Oral Diagnosis, Sao Paulo State University, Sao Paulo, SP, Brazil, CEP 12243 080
    Braz Oral Res 21:4-9. 2007
    ..In conclusion, although the total etching and self-etching systems presented similar shear bond strength values, the types of fracture presented by them were different, which can have clinical implications...
  51. ncbi Effect of 2-hydroxyethyl methacrylate on Streptococcus spp. biofilms
    S D'Ercole
    Department of Biomedical Sciences, University G D Annunzio, Chieti Pescara, Chieti, Italy
    Lett Appl Microbiol 52:193-200. 2011
    ..The effect of different concentrations of 2-hydroxyethyl methacrylate (HEMA) was evaluated on biofilm formation and preformed biofilm of Streptococcus mitis, Streptococcus mutans and Streptococcus oralis, alone or combined to each other...
  52. ncbi Bond strength of two resin cements to titanium after different surface conditioning methods
    Mutlu Ozcan
    University of Zurich, Head of Dental Materials Unit, Center for Dental and Oral Medicine Clinic for Fixed and Removable Prosthodontics and Dental Materials Science, Switzerland
    Gen Dent 60:e6-e12. 2012
    ....
  53. ncbi The repair potential of resin composite materials
    Chaiwat Maneenut
    Faculty of Dentistry, Chulalongkorn University, Henri Dunant Rd, Bangkok, Thailand
    Dent Mater 27:e20-7. 2011
    ....
  54. pmc Effect of incorporation of 2-tert-butylaminoethyl methacrylate on flexural strength of a denture base acrylic resin
    André Gustavo Paleari
    Department of Dental Materials and Prosthodontics, Araraquara Dental School, Sao Paulo State University, Araraquara, SP, Brazil
    J Appl Oral Sci 19:195-9. 2011
    ..It is hypothesized that the 2-tert-butylaminoethyl methacrylate (TBAEMA) incorporated to acrylic resins should have antimicrobial activity related to the presence of amino groups on acrylic resin surface...
  55. ncbi Effect of metal primers on bond strength of resin cements to base metals
    Renata Garcia Fonseca
    Department of Dental Materials and Prosthodontics, Araraquara Dental School, Sao Paulo State University UNESP, Araraquara, Sao Paulo, Brazil
    J Prosthet Dent 101:262-8. 2009
    ..A strong and durable bond between a metal framework and a resin-based luting agent is desired. Metal primers have been shown to be very effective on noble alloys. However, there is insufficient information about their effect on base metals...
  56. ncbi Adhesive bonding of resin cements to cast titanium with adhesive primers
    Marina Di Francescantonio
    Department of Restorative Dentistry, Piracicaba Dental School, University of Campinas, SP, Brazil
    Braz Dent J 23:218-22. 2012
    ..Panavia F 2.0 and RelyX ARC yielded high bond strength means with or without adhesive primers. The use of adhesive primers might increase the bond strength to cast titanium depending on the resin cement used...
  57. pmc Six-month evaluation of a resin/dentin interface created by methacrylate and silorane-based materials
    Renata Kirita Doi Sampaio
    University North of Parana, Londrina, PR, Brazil
    J Appl Oral Sci 21:80-4. 2013
    ..This study aimed to compare the micro-tensile bond strength of methacrylate resin systems to a silorane-based restorative system on dentin after 24 hours and six months water storage...
  58. ncbi Does the acidity of self-etching primers affect bond strength and surface morphology of enamel?
    Sandra Kiss Moura
    Department of Dental Materials, University of Sao Paulo, FOUSP, Brazil
    J Adhes Dent 8:75-83. 2006
    ..This study examined the ultrastructure and microtensile bond strengths (TBS) of self-etching (with different acidity) and conventional adhesive systems bonded to unground enamel...
  59. ncbi Effect of silane coupling agents and alloy primers on adhesion to titanium
    M Ozcan
    Unit of Dental Materials, University of Zurich, Zurich, Switzerland
    Minerva Stomatol 60:427-34. 2011
    ..This study evaluated the adhesion of resin composite to titanium alloy using different silane coupling agents and alloy primers in combination with surface conditioning methods after aging...
  60. ncbi Phosphorylcholine-polycation diblock copolymers as synthetic vectors for gene delivery
    J K W Lam
    School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK
    J Control Release 100:293-312. 2004
    ....
  61. ncbi Alterations of energy metabolism and glutathione levels of HL-60 cells induced by methacrylates present in composite resins
    G Nocca
    Biochemistry and Clinical Biochemistry Institute, School of Medicine, Catholic University, Rome, Italy
    J Dent 35:187-94. 2007
    ....
  62. ncbi TEM characterization of a silorane composite bonded to enamel/dentin
    Atsushi Mine
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, Leuven, Belgium
    Dent Mater 26:524-32. 2010
    ..The purpose of this study was to characterize the interfacial ultra-structure at enamel and dentin using transmission electron microscopy (TEM)...
  63. ncbi Effects of triazine dithione and hydrophobic phosphate monomers on bonding to Ag-Pd-Cu-Au alloy and titanium with a methacrylic resin-based luting agent
    Hiroyasu Koizumi
    Department of Fixed Prosthodontics, and Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry, Chiyoda ku, Tokyo, Japan
    J Adhes Dent 12:215-22. 2010
    ..The purpose of the current study was to evaluate the effects of thione and phosphate functional monomers on bond strength and durability of a methacrylic resin luting agent joined to silver-palladium based alloy and titanium...
  64. ncbi Evaluation of a new universal primer for ceramics and alloys
    Farhad Azimian
    Department of Prosthodontics, Propaedeutics and Dental Materials, School of Dentistry, Christian Albrechts University, Kiel, Germany
    J Adhes Dent 14:275-82. 2012
    ..To evaluate in vitro the effect of using a universal primer on the resin bond strength to ceramics (silicate and zirconia) and two noble alloys for metal-ceramic restorations...
  65. ncbi The effect of phosphoric acid pre-etching and thermocycling on self-etching adhesive enamel bonding
    James L Sheets
    Department of Prosthodontics, Creighton University School of Dentistry, Omaha, NE 68178, USA
    J Prosthet Dent 107:102-8. 2012
    ....
  66. pmc The inhibitory effects of quaternary ammonium methacrylates on soluble and matrix-bound MMPs
    A Tezvergil-Mutluay
    Department of Prosthodontics and Turku Clinical Biomaterials Center, University of Turku, Institute of Dentistry, Lemminkaisenkatu 2, FI 20520 Turku, Finland
    J Dent Res 90:535-40. 2011
    ..This study evaluated the MMP-inhibiting potential of quaternary ammonium methacrylates (QAMs), with soluble rhMMP-9 and a matrix-bound endogenous MMP model...
  67. ncbi Adhesive bonding of Ti-6Al-7Nb alloy and component metals with acidic primers and a tri-n-butylborane initiated resin
    Hiroyasu Koizumi
    Department of Fixed Prosthodontics, Nihon University School of Dentistry, Tokyo, Japan
    J Adhes Dent 14:283-92. 2012
    ..To evaluate the effects of acidic functional monomers on the bond strength and durability of an acrylic resin joined to Ti-6Al-7Nb alloy and component metals...
  68. ncbi Hybrid cell death induced by exposure to 2-hydroxyethyl methacrylate (HEMA): an ultrastructural and X-ray microanalytical study
    Ismael A Rodriguez
    Histology Department B, Faculty of Odontology, National University of Cordoba, Cordoba, Argentina
    J Adhes Dent 10:105-11. 2008
    ....
  69. ncbi Antioxidative vitamins decrease cytotoxicity of HEMA and TEGDMA in cultured cell lines
    U I Walther
    Walther Straub Institut für Pharmakologie und Toxikologie der Ludwig Maximilians Universität, Nussbaumstr 26, 80336 Munchen, Germany
    Arch Oral Biol 49:125-31. 2004
    ....
  70. ncbi Effects of mechanical cycling on the bonding of zirconia and fiber posts to human root dentin
    Marco Antonio Bottino
    Department of Dental Materials and Prosthodontics, Sao Jose dos Campos Dental School, Sao Paulo State University UNESP, Brazil
    J Adhes Dent 9:327-31. 2007
    ..To evaluate the effect of cyclical mechanical loading on the bond strength of a fiber and a zirconia post bonded to root dentin...
  71. ncbi The stability of methacrylate biomaterials when enzyme challenged: kinetic and systematic evaluations
    D M Yourtee
    Division of Pharmacology, Toxicore Laboratory, School of Pharmacy, University of Missouri, Kansas City, Missouri 64108, USA
    J Biomed Mater Res 57:522-31. 2001
    ..Particularly resistant were aromativ derivatives and those with branching in methacrylate linkages. Overall, the study confirms the ability of physiologically important esterases to catalyze the hydrolysis of biomaterial methacrylates.
  72. ncbi Effects of aging and HEMA content on the translucency, fluorescence, and opalescence properties of experimental HEMA-added glass ionomers
    Yong keun Lee
    Denforus Co, I B Diosuperium, Seocho Gu, Seoul, Korea
    Dent Mater J 29:9-14. 2010
    ..In addition, results of this study showed that apart from optimal HEMA ratio, future studies should include other aspects and factors that contribute to age-dependent changes in optical properties...
  73. ncbi Identification of 2,3-epoxymethacrylic acid as an intermediate in the metabolism of dental materials in human liver microsomes
    Mario Seiss
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, 80336 Munich, Germany
    Dent Mater 23:9-16. 2007
    ..This study was performed to identify the possible dental material intermediate 2,3-epoxymethacrylic acid (2,3-EMA) from MA in human liver microsomes. Most epoxy compounds are regarded as highly toxic substances...
  74. ncbi The effect of ferrule on the fracture mode of endodontically treated canines restored with fibre posts and metal-ceramic or all-ceramic crowns
    Theodora Fragou
    Department of Fixed Prosthesis and Implant Prosthodontics, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    J Dent 40:276-85. 2012
    ....
  75. ncbi HEMA reduces cell proliferation and induces apoptosis in vitro
    J T Samuelsen
    NIOM Nordic Institute of Dental Materials, N 1305 Haslum, Norway
    Dent Mater 24:134-40. 2008
    ..The aim of this study was to investigate potential cellular responses following long-term exposure to relatively low and potentially more clinical relevant HEMA concentrations...
  76. pmc Thermally responsive injectable hydrogel incorporating methacrylate-polylactide for hydrolytic lability
    Zuwei Ma
    McGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Biomacromolecules 11:1873-81. 2010
    ..The synthesized hydrogels provide new options for biomaterial injection therapy where increased mechanical strength and relatively slow resorption rates would be attractive...
  77. ncbi Inhibition of TXA synthesis with OKY-046 improves liver preservation by prolonged hypothermic machine perfusion in rats
    Hongzhi Xu
    Department of Biology, University of North Carolia at Charlotte, Charlotte, North Carolina 28223, USA
    J Gastroenterol Hepatol 23:e212-20. 2008
    ..The underlying injury mechanism is not well understood. The present study sought to investigate the role of thromboxane A(2) (TXA(2)) in the pathogenesis of liver injury after prolonged HMP...
  78. ncbi Respiratory effects of exposure to methacrylates among dental assistants
    M S Jaakkola
    Institute of Occupational and Environmental Medicine, University of Birmingham, Birmingham, UK
    Allergy 62:648-54. 2007
    ..published, but there is little data on the risk of respiratory disorders related to occupational exposure to methacrylates in dental assistants...
  79. ncbi Development of microporous drug-releasing films cast from artificial nanosized latexes of poly(styrene-co-methyl methacrylate) or poly(styrene-co-ethyl methacrylate)
    Daniel P Otto
    School of Pharmacy, University of Wisconsin Madison, WI 53705, USA
    Eur J Pharm Biopharm 69:1121-34. 2008
    ..Depending on the application, one could select the copolymer films that best suited the application i.e. for short-term drug release applications such as urinary catheters or long-term applications such as artificial implants...
  80. ncbi Infrared reflection absorption spectroscopy coupled with Brewster angle microscopy for studying interactions of amphiphilic triblock copolymers with phospholipid monolayers
    Elkin Amado
    Department of Chemistry, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Langmuir 24:10041-53. 2008
    ....
  81. ncbi Characterisation of QoI-resistant field isolates of Botrytis cinerea from citrus and strawberry
    Hideo Ishii
    National Institute for Agro Environmental Sciences, Tsukuba, Ibaraki 305 8604, Japan
    Pest Manag Sci 65:916-22. 2009
    ..Biological and molecular characterisation of resistant isolates was conducted in this study...
  82. ncbi In vitro stability of methylmethacrylic acid, TEGDMA and HEMA exposed to esterases
    Mario Seiss
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, 80336 Munich, Germany
    Dent Mater 25:1044-9. 2009
    ....
  83. ncbi Volatile methacrylates in dental practices
    Wolfgang Marquardt
    Department of Operative Dentistry and Periodontology, Ludwig Maximilians University, Munich, Germany
    J Adhes Dent 11:101-7. 2009
    In recent years, an increase of occupational respiratory diseases, such as asthma caused by methacrylates, has been observed in dental personnel...
  84. pmc Dynamic mechanical analysis and esterase degradation of dentin adhesives containing a branched methacrylate
    Jong Gu Park
    Bioengineering Research Center, University of Kansas, Lawrence, Kansas, USA
    J Biomed Mater Res B Appl Biomater 91:61-70. 2009
    ..The improved esterase resistance of the new adhesive could be explained in terms of the densely crosslinked network structure and/or the steric hindrance of branched alkyl side chains...
  85. ncbi Designing temperature-responsive biocompatible copolymers and hydrogels based on 2-hydroxyethyl(meth)acrylates
    Olga V Khutoryanskaya
    Reading School of Pharmacy, University of Reading, Whiteknights, P O Box 224, RG6 6AD, Reading, United Kingdom
    Biomacromolecules 9:3353-61. 2008
    ..The assessment of the biocompatibility of the copolymers using the slug mucosal irritation test revealed that they are also less irritant than poly(acrylic acid)...
  86. ncbi Influence of incorporation of fluoroalkyl methacrylates on roughness and flexural strength of a denture base acrylic resin
    Tatiana Ramirez Cunha
    Dental School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Appl Oral Sci 17:103-7. 2009
    ..The addition of FMA into denture base resin may lower the flexural strength and modulus of elasticity, regardless of the tested concentration...
  87. ncbi Mechanisms of N-acetyl cysteine-mediated protection from 2-hydroxyethyl methacrylate-induced apoptosis
    Avina Paranjpe
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, The Jonsson Comprehensive Cancer Center JCCC, Dental Research Institute, Division of Oral Biology and Medicine, Los Angeles, CA, USA
    J Endod 34:1191-7. 2008
    ..Overall, the results reported in this article indicate that NAC is an effective chemoprotectant that can safely be used to protect the pulp and the surrounding tissues from adverse effects of dental restorative and endodontic materials...
  88. ncbi Novel hydrogel membrane based on copoly(hydroxyethyl methacrylate/p-vinylbenzyl-poly(ethylene oxide)) for biomedical applications: properties and drug release characteristics
    M Yakup Arica
    Biochemical Processing and Biomaterial Research Laboratory, Faculty of Science, Kirikkale University, 71450 Yahşihan Kirikkale, Turkey
    Macromol Biosci 5:983-92. 2005
    ..4. This membrane composition provided the best results and can be considered as a potential candidate for a transdermal antibiotic carrier and various biomedical and biotechnological applications...
  89. ncbi Genotoxicity and cytotoxicity of 2-hydroxyethyl methacrylate
    Elzbieta Pawlowska
    Department of Pediatric Dentistry, Medical University of Lodz, Pomorska 251, 92 216 Lodz, Poland
    Mutat Res 696:122-9. 2010
    ..Chitosan and its derivatives can be considered as additional components of dental restoration to decrease the harmful potency of HEMA...
  90. ncbi Clonal variation in physiological responses of Daphnia magna to the strobilurin fungicide azoxystrobin
    Trine Perlt Warming
    Freshwater Biological Laboratory, University of Copenhagen, Helsingørsgade 51, DK 3400 Hillerød, Denmark
    Environ Toxicol Chem 28:374-80. 2009
    ..Thus, ponds in the agricultural areas may experience changes in food-web structure even at very low concentrations of azoxystrobin...
  91. ncbi QSAR models to predict mutagenicity of acrylates, methacrylates and alpha,beta-unsaturated carbonyl compounds
    Alfonso Pérez-Garrido
    Enviromental Engineering and Toxicology Dpt, Catholic University of San Antonio, Guadalupe, Murcia, Spain
    Dent Mater 26:397-415. 2010
    ....
  92. ncbi Occupational skin diseases among dental nurses
    Kristiina Alanko
    Finnish Institute of Occupational Health, Helsinki, Finland
    Contact Dermatitis 50:77-82. 2004
    ..Plastic gloves or NRL gloves with a low-protein content are recommended for dental work. Skin exposure to (meth)acrylates should be avoided...
  93. ncbi Exposure to airborne methacrylates and natural rubber latex allergens in dental clinics
    M L Henriks-Eckerman
    Turku Regional Institute of Occupational Health, Turku, Finland
    J Environ Monit 3:302-5. 2001
    The exposure of dental personnel to airborne methacrylates and natural rubber latex (NRL) allergens was studied during placing of composite resin restorations in six dental clinics in Finland...
  94. ncbi Methacrylates in dental restorative materials
    Maj Len Henriks-Eckerman
    Turku Regional Institute of Occupational Health, Hameenkatu 10, FIN 20500 Turku, Finland
    Contact Dermatitis 50:233-7. 2004
    ..Acetone-soluble methacrylates of 7 bonding materials, 8 composite resins and 2 glass ionomers were identified by gas chromatography with ..
  95. ncbi Residues of azoxystrobin from grapes to raisins
    Chaido Lentza-Rizos
    National Agricultural Research Foundation, 1 Sophocli Venizelou Street, 141 23 Lykovrissi, Greece
    J Agric Food Chem 54:138-41. 2006
    ..51-1.49 (treatment 1) and 1.42-2.08 mg/kg (treatment 2), with residue transfer factors sometimes >1, even following alkali treatment, which reduced residues considerably. To avoid trade problems, a higher MRL for raisins is necessary...
  96. ncbi Occupational asthma caused by sculptured nails containing methacrylates
    Riitta Sauni
    Team of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Am J Ind Med 51:968-74. 2008
    In recent decades, the use of artificial nails including methacrylates (MAs) has increased. This study presents the first two clinical cases of occupational asthma (OA) caused by sculptured nails containing MAs.
  97. ncbi The microleakage between alloy and polymeric materials in veneer crowns
    Sorin Lakatos
    Department of Dental Materials and Prosthesis Technology, University School of Dentistry Timişoara, Romania
    Quintessence Int 34:295-300. 2003
    ..This study investigated the cervical microleakage between a cobalt-chromium (Co-Cr) alloy and four indirect polymeric veneering materials using different adhesive systems...
  98. ncbi Bonding of prosthetic composite material to Ti-6Al-7Nb alloy with eight metal conditioners and a surface modification technique
    H Yanagida
    Department of Fixed Prosthodontics, Nagasaki University School of Dentistry, Japan
    Am J Dent 14:291-4. 2001
    ....
  99. ncbi Influence of hyperbranched multi-methacrylates for dental neat resins on proliferation of human gingival fibroblasts
    Q Wan
    College of Dentistry, The Ohio State University, 305 West 12th Street, P.O. Box 182357, Columbus, Ohio 43218-2357, USA
    Biomacromolecules 2:217-22. 2001
    ..All these results suggest that the biocompatibility of H-MMA-modified dental neat resins is as good as that of commercially used BisGMA/TEGDMA resin and H-MMA has potential applications in dental composites...
  100. ncbi Effects of cavity configuration on composite restoration
    Kyoung Kyu Choi
    Department of Conservative Dentistry, School of Dentistry, Kyunghee University, Seoul, Korea
    Oper Dent 29:462-9. 2004
    ..Mean microtensile bond strength to dentin was also decreased with increasing C-factor for both types of composites. Microleakage scores for the hybrid composite restorations were generally higher than the microhybrid composite...
  101. ncbi Alternative oxidase reduces the sensitivity of Mycosphaerella graminicola to QOI fungicides
    Monica Miguez
    Department of Environmental Sciences, University Pablo de Olavide, Seville, Spain
    Pest Manag Sci 60:3-7. 2004
    ..Using QOIs preventatively reduces the risk of resistance since the alternative oxidase cannot by itself generate all the energy needed for germination and early infection...

Research Grants35

  1. Biocompatible PEG-Functionalized Methacrylates
    William Collins; Fiscal Year: 2003
    ..Macrophage chemotaxis and phagocytosis will be assessed. The morphology of adherent macrophages and HCE- I cells will also be examined with scanning electron microscopy. ..
  2. Dental Composite Materials Based on Photoinitiated Thiol-Vinyl Sulfone Reactions
    Christopher N Bowman; Fiscal Year: 2013
    ..dental restorative materials is plagued by critical problems;they do not achieve complete conversion of the methacrylates and thus leave a great deal of material that can be extracted into the oral environment...
  3. ORAL MUCOSAL CELL RESPONSES TO DENTAL RESIN COMPONENTS
    George Schuster; Fiscal Year: 1999
    ..The specific aims of the current proposal are to examine 1) hydrolysis of the methacrylates and their effects on cell lipid metabolism of oral epithelial and connective tissue cells, as well as a non-..
  4. NOVEL SOLID PHASE SUPPORTS FOR COMBINATORIAL CHEMISTRY
    JEAN FRECHET; Fiscal Year: 2001
    ..In addition to the direct use of non-traditional monomers, such as methacrylates and substituted styrenes, spatially targeted modification reactions will result in supports allowing unique ..
  5. NOVEL CROSSLINK POLYMERS FOR DENTAL RESTORATIONS
    Christopher Bowman; Fiscal Year: 1999
    ..presently used monomer resins by incorporating different dimethacrylates as well as tri-, tetra-, and penta-methacrylates into the reaction mixture...
  6. Novel Nanostructured Dental Glass-Ionomers for Advanced Dental Restoratives
    Dong Xie; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Novel Amino Acid-Based Glass-Ionomer Biomaterials
    Dong Xie; Fiscal Year: 2005
    ..abstract_text> ..
  8. Molecular/Mechanical Imaging of Dentin Bonding Substrate
    Yong Wang; Fiscal Year: 2007
    ..Results from this work will provide critical, new insight into failure mechanisms at the dentin/adhesive interface; failure that can ultimately lead to premature breakdown of the composite restoration. ..
  9. IMPROVED PREVENTIVE/RESTORATIVE RESINS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2006
    ..The data gathered in these experiments will serve to support a larger R01 grant application with the long-term objectives of developing improved durable materials for adhesives and adhesive composites. [unreadable] [unreadable]..
  10. Dentin/Adhesive Interface Structure/Property Imaging
    Yong Wang; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  11. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2009
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  12. Cell Membrane Simulators in Biocompatibility Testing
    DAVID YOURTEE; Fiscal Year: 2006
    ..This will enable the prediction of destructive properties of untested compounds and ensure the design of new non-toxic membrane dental materials. ..
  13. AMPHIPATHIC ORAL CHELATORS AND RADIONUCLIDE CONTAMINATION
    Scott Miller; Fiscal Year: 2008
    ..Because the pharmacology and toxicology of PACA chelators, such as DTPA and EDTA, are quite well understood, the development pathway of the related TT- based chelators may proceed rapidly. ..
  14. MECHANISMS OF SKELETAL RECONSTITUTION AFTER LACTATION
    Scott Miller; Fiscal Year: 2004
    ..abstract_text> ..
  15. The Role of BCL-2 in Corneal Epithelial Cell Shedding
    DANIELLE ROBERTSON; Fiscal Year: 2008
    ..4) That events leading to increased apoptosis such as UV light signal surface cell apoptosis through the phosphorylation of BCL-2. ..
  16. Macromolecular Therapy for Improved Treatment of Rheumatoid Arthritis
    Dong Wang; Fiscal Year: 2009
    ..Eventually, this novel delivery system would lead to improved efficacy and safety profiles for treatment of rheumatoid arthritis and other inflammatory joint disorders. ..
  17. Viral vector-based RNAi therapy for Alexander Disease
    Daniel Bonthius; Fiscal Year: 2008
    ..The disease is due to an abnormal gene. This research aims to develop a form of gene therapy to prevent and reverse the brain dysfunction of Alexander Disease. [unreadable] [unreadable] [unreadable]..
  18. Preventive of Bile Acid-Induced Colonic Oxidative DNA Damage
    Claire Margaret Payne; Fiscal Year: 2010
    ..129 mice) developed in our laboratory;2) NOS-/- k.o./DOC mouse model;3) arginine-enhanced colon tumor ApcMin/+ mouse model developed in our laboratory;4) the AOM mouse model of colon carcinogenesis using A/J mice. ..
  19. Microchip to Detect Influenza Infection and Type in Nasopharyngeal Swabs
    Catherine M Klapperich; Fiscal Year: 2010
    ....
  20. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2010
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  21. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2007
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  22. Cytochrome C Oxidase I:A Biomarker for Colon Cancer Risk
    Claire Payne; Fiscal Year: 2006
    ..Various molecular and cellular techniques will be used in these studies. ..
  23. Biomimetic Adhesive for Mineralized Tissues
    John Mitchell; Fiscal Year: 2005
    ..Additionally we will characterize the changes in the interface between tooth and restoration. ..
  24. A novel therapy for advanced periodontitis
    Edward Boland; Fiscal Year: 2005
    ..The result of this project will be the preliminary development of a safe, effective and low maintenance treatment for periodontitis which will prevent tooth loss in affected patients. ..
  25. Dental Composite Resins with Polymer Nanofibers
    Hao Fong; Fiscal Year: 2005
    ....
  26. CONTROLLED-RELEASE SEALANT TO PREVENT SECONDARY CARIES
    Kenneth Anusavice; Fiscal Year: 2004
    ..mutans, site specific levels of S. mutans at the margins of amalgam and composite restorations, and the width of marginal crevices adjacent to amalgam and composite restorations). ..
  27. 3D Crystal Structure: Vertebrate Mitochondria Complex II
    EDWARD BERRY; Fiscal Year: 2005
    ..Finally (e) we want to crystallize a related complex n from an organism amenable to site-directed mutagenesis. ..
  28. 3D CRYSTALS OF CYTOCHROME REDUCTASE, A MEMBRANE PROTEIN
    EDWARD BERRY; Fiscal Year: 2006
    ..5) Structural studies of functionally relevant mutant bacterial and yeast complexes. ..
  29. HYBRIDIZED DENTIN: BIOMIMETIC MODELING AND OPTIMIZATION
    Jayalakshmi Vaidyanathan; Fiscal Year: 2006
    ..Binding studies between the ligands and collagen will be conducted by:1) a novel immunochemical binding assay developed by us; and 2) isothermal titration calorimetry, and related to computed interaction energy values. ..
  30. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2006
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  31. Determinants of the Durability of Resin-Dentin Bonds
    David Pashley; Fiscal Year: 2006
    ..This should provide important new insight into designing more durable resin-dentin bonds that can justify the placement of resin-based posterior composites. ..
  32. NEUROTERATOGENIC MECHANISM OF LCM VIRUS INFECTION
    Daniel Bonthius; Fiscal Year: 2005
    ..The importance of a-DG in influencing the tropism and infectivity of LCMV will be examined by blocking alpha-DG with an antibody prior to exposure of brain slices to LCMV. ..
  33. Thiol-Ene Polymers as Dental Restorative Materials
    NEIL CRAMER; Fiscal Year: 2006
    ..The compatibility of monomer formulations with filler particles and the properties of filled systems will be evaluated. Biocompatibility of the new dental restorative materials will also be assessed. ..
  34. CERAMIC WHISKER REINFORCEMENT OF DENTAL COMPOSITE RESINS
    HUAKUN XU; Fiscal Year: 2002
    ....