acetates

Summary

Summary: Salts or esters of acetic acid in which the terminal hydrogen atom is replaced by a metal, for instance copper acetate Cu(CH3COO)2, or where substitution is by a radical, for instance ethyl acetate CH3COOC2H5. (From Hawley's Condensed Chemical Dictionary, 12th ed)

Top Publications

  1. pmc The acetate switch
    Alan J Wolfe
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Microbiol Mol Biol Rev 69:12-50. 2005
  2. ncbi Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein
    John D Laughlin
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, M S 8303, P O Box 6511, Aurora, CO 80045, USA
    Cell 133:1255-65. 2008
  3. pmc Receptors and neurons for fly odors in Drosophila
    Wynand Van der Goes van Naters
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 17:606-12. 2007
  4. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
  5. ncbi Methyl jasmonate as a vital substance in plants
    Jong Joo Cheong
    School of Agricultural Biotechnology, Seoul National University, Suwon 441 744, South Korea
    Trends Genet 19:409-13. 2003
  6. pmc Modulation of CYP79 genes and glucosinolate profiles in Arabidopsis by defense signaling pathways
    Michael Dalgaard Mikkelsen
    Plant Biochemistry Laboratory, Department of Plant Biology, The Royal Veterinary and Agricultural University, Thorvaldsensvej 40, opgang 10, St, DK 1871 Frederiksberg C, Copenhagen, Denmark
    Plant Physiol 131:298-308. 2003
  7. pmc Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila
    Liming Wang
    Division of Biology 216 76, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 463:227-31. 2010
  8. ncbi Cytosolic alkalization and cytosolic calcium oscillation in Arabidopsis guard cells response to ABA and MeJA
    Mohammad Mahbub Islam
    Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    Plant Cell Physiol 51:1721-30. 2010
  9. ncbi Roles of RCN1, regulatory A subunit of protein phosphatase 2A, in methyl jasmonate signaling and signal crosstalk between methyl jasmonate and abscisic acid
    Naoki Saito
    Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    Plant Cell Physiol 49:1396-401. 2008
  10. pmc Generalization of courtship learning in Drosophila is mediated by cis-vaccenyl acetate
    Aki Ejima
    Department of Biology and Volen Center for Complex Systems, Brandeis University, MS008, Waltham, MA 02454, USA
    Curr Biol 17:599-605. 2007

Research Grants

Detail Information

Publications403 found, 100 shown here

  1. pmc The acetate switch
    Alan J Wolfe
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Microbiol Mol Biol Rev 69:12-50. 2005
    ..Next, the way in which cells regulate AMP-ACS activity through reversible acetylation is described. Finally, the "acetate switch" as it exists in selected eubacteria, archaea, and eukaryotes, including humans, is described...
  2. ncbi Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein
    John D Laughlin
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, M S 8303, P O Box 6511, Aurora, CO 80045, USA
    Cell 133:1255-65. 2008
    ..Therefore, the pheromone-binding protein is an inactive, extracellular ligand converted by pheromone molecules into an activator of pheromone-sensitive neurons and reveals a distinct paradigm for detection of odorants...
  3. pmc Receptors and neurons for fly odors in Drosophila
    Wynand Van der Goes van Naters
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 17:606-12. 2007
    ..We propose a model describing how these receptors might be used by a male to distinguish suitable from unsuitable mating partners through a simple logic...
  4. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
    ....
  5. ncbi Methyl jasmonate as a vital substance in plants
    Jong Joo Cheong
    School of Agricultural Biotechnology, Seoul National University, Suwon 441 744, South Korea
    Trends Genet 19:409-13. 2003
    ..Recent approaches using functional genomics and bioinformatics have identified a whole set of MeJA-responsive genes, and provide insights into how plants use volatile signals to withstand diverse and variable environments...
  6. pmc Modulation of CYP79 genes and glucosinolate profiles in Arabidopsis by defense signaling pathways
    Michael Dalgaard Mikkelsen
    Plant Biochemistry Laboratory, Department of Plant Biology, The Royal Veterinary and Agricultural University, Thorvaldsensvej 40, opgang 10, St, DK 1871 Frederiksberg C, Copenhagen, Denmark
    Plant Physiol 131:298-308. 2003
    ..Thus, different defense pathways activate subsets of biosynthetic enzymes, leading to the accumulation of specific glucosinolates...
  7. pmc Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila
    Liming Wang
    Division of Biology 216 76, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 463:227-31. 2010
    ..Identification of a pheromone-OSN pair controlling aggression in a genetic organism opens the way to unravelling the neurobiology of this evolutionarily conserved behaviour...
  8. ncbi Cytosolic alkalization and cytosolic calcium oscillation in Arabidopsis guard cells response to ABA and MeJA
    Mohammad Mahbub Islam
    Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    Plant Cell Physiol 51:1721-30. 2010
    ..These results indicate that cytosolic alkalization and cytosolic Ca(2+) oscillation coordinately function in ABA and MeJA signaling in Arabidopsis guard cells...
  9. ncbi Roles of RCN1, regulatory A subunit of protein phosphatase 2A, in methyl jasmonate signaling and signal crosstalk between methyl jasmonate and abscisic acid
    Naoki Saito
    Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    Plant Cell Physiol 49:1396-401. 2008
    ..These results suggest that RCN1 functions upstream of ROS production and downstream of the branch point of MeJA signaling and ABA signaling in Arabidopsis guard cells...
  10. pmc Generalization of courtship learning in Drosophila is mediated by cis-vaccenyl acetate
    Aki Ejima
    Department of Biology and Volen Center for Complex Systems, Brandeis University, MS008, Waltham, MA 02454, USA
    Curr Biol 17:599-605. 2007
    ..These findings suggest that transfer of cVA to females during mating may be part of the male's strategy to suppress reproduction by competing males...
  11. pmc Comparisons of LIPOXYGENASE3- and JASMONATE-RESISTANT4/6-silenced plants reveal that jasmonic acid and jasmonic acid-amino acid conjugates play different roles in herbivore resistance of Nicotiana attenuata
    Lei Wang
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany
    Plant Physiol 146:904-15. 2008
    ....
  12. ncbi A pheromone receptor mediates 11-cis-vaccenyl acetate-induced responses in Drosophila
    Tal Soo Ha
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:8727-33. 2006
    ..Here, we show LUSH are also required in non-T1 neurons misexpressing the receptor to respond to VA. These data provide new insight into the molecular components and neuronal basis of volatile pheromone perception...
  13. ncbi COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility
    D X Xie
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Science 280:1091-4. 1998
    ..It has similarity to the F-box proteins Arabidopsis TIR1, human Skp2, and yeast Grr1, which appear to function by targeting repressor proteins for removal by ubiquitination...
  14. pmc The jasmonate signal pathway
    John G Turner
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Plant Cell 14:S153-64. 2002
  15. pmc Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure
    Dontamala Suhita
    CEA Cadarache DSV DEVM, Laboratoire des Echanges Membranaires et Signalisation, UMR 163 CNRS CEA, Universite de la Mediterranee, 13108 St Paul lez Durance Cedex, France
    Plant Physiol 134:1536-45. 2004
    ..Our results further indicate that JAR1, as OST1, functions upstream of ROS produced by NAD(P)H oxidases and that the cytoplasmic alkalization precedes ROS production during MJ or ABA signal transduction in guard cells...
  16. ncbi Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites
    H Mechiche
    Laboratory of Pharmacology, EA 2070, Faculty of Medicine, Reims, France
    Clin Exp Allergy 33:887-94. 2003
    ..Montelukast (MK), a specific CysLT1 receptor antagonist, is metabolized in two main hydroxylated metabolites (termed M5 and M6, respectively)...
  17. ncbi A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model
    William R Henderson
    Departments of Medicine and Pathology, University of Washington, Seattle, Washington 98195 6523, USA
    Am J Respir Crit Care Med 165:108-16. 2002
    ..These data suggest an important role for cysteinyl leukotrienes in the pathogenesis of chronic allergic airway inflammation with fibrosis...
  18. pmc Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells
    Laurens Pauwels
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 105:1380-5. 2008
    ....
  19. pmc Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism
    Vincent Lebon
    Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:1523-31. 2002
    ..The further application of this approach could potentially enlighten the role of astroglia in supporting brain glutamatergic activity and in neurological and psychiatric disease...
  20. ncbi Ammonia, a selective agent for methane production by syntrophic acetate oxidation at mesophilic temperature
    A Schnurer
    Department of Microbiology, Swedish University of Agricultural Sciences, Box 7025, S 750 07 Uppsala, Sweden
    Water Sci Technol 57:735-40. 2008
    ..No shift in pathway was seen during increasing concentrations of sodium, potassium or propionic acid. The shift to SAO in the biogas digester resulted in a twofold decrease in the specific gas and methane yield...
  21. ncbi Coordinated activation of metabolic pathways for antioxidants and defence compounds by jasmonates and their roles in stress tolerance in Arabidopsis
    Yuko Sasaki-Sekimoto
    Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Yokohama, Kanagawa, 226 8501, Japan
    Plant J 44:653-68. 2005
    ..Compared with the wild type, opr3 mutants were more sensitive to O3 exposure. These results suggest that the coordinated activation of the metabolic pathways mediated by jasmonates provides resistance to environmental stresses...
  22. ncbi Targeted proteomics using selected reaction monitoring reveals the induction of specific terpene synthases in a multi-level study of methyl jasmonate-treated Norway spruce (Picea abies)
    Katherine G Zulak
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    Plant J 60:1015-30. 2009
    ....
  23. ncbi Oral montelukast in acute asthma exacerbations: a randomised, double-blind, placebo-controlled trial
    Crichton F Ramsay
    Department of Respiratory Medicine, Norfolk and Norwich University Hospital, Norwich, UK
    Thorax 66:7-11. 2011
    ..Although leukotriene receptor antagonists have an established role in the management of patients with chronic asthma, their efficacy in an acute asthma exacerbation is not fully known...
  24. ncbi Effect of addition of single dose of oral montelukast to standard treatment in acute moderate to severe asthma in children between 5 and 15 years of age: a randomised, double-blind, placebo controlled trial
    Vivek Kumar Todi
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India
    Arch Dis Child 95:540-3. 2010
    ..To study the effect of the addition of a single dose of oral montelukast to standard therapy in acute moderate to severe asthma...
  25. pmc Overflow metabolism in Escherichia coli during steady-state growth: transcriptional regulation and effect of the redox ratio
    G N Vemuri
    Center for Molecular BioEngineering, Driftmier Engineering, University of Georgia, Athens, GA 30602, USA
    Appl Environ Microbiol 72:3653-61. 2006
    ..The results provide a basis for studying new regulatory mechanisms prevalent at reduced NADH/NAD ratios, as well as for designing more efficient bioprocesses...
  26. ncbi A conditionally fertile coi1 allele indicates cross-talk between plant hormone signalling pathways in Arabidopsis thaliana seeds and young seedlings
    Christine Ellis
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Planta 215:549-56. 2002
    ..We have used coi1-16 seeds to define novel interactions between JA and other hormone signalling pathways in seed germination and in the development of young seedlings...
  27. pmc Cysteinyl leukotriene receptor antagonists inhibit tumor metastasis by inhibiting capillary permeability
    Masako Nozaki
    Department of Clinical Pharmacology, Tokai University School of Medicine, Kanagawa, Japan
    Keio J Med 59:10-8. 2010
    ..These results show that pranlukast can inhibit tumor cell migration through both the brain and peripheral capillaries, whereas montelukast inhibits tumor cell migration only in the peripheral capillaries...
  28. pmc Evaluation of calcium acetate/magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: a controlled randomized study (CALMAG study) assessing efficacy and tolerability
    Angel L M de Francisco
    Hospital Marques de Valdecilla, Universidad de Cantabria, Santander, Spain
    Nephrol Dial Transplant 25:3707-17. 2010
    ..Phosphate binders are required to control serum phosphorus in dialysis patients. A phosphate binder combining calcium and magnesium offers an interesting therapeutic option...
  29. ncbi Functional identification and regulation of the PtDrl02 gene promoter from triploid white poplar
    Huiquan Zheng
    National Engineering Laboratory for Tree Breeding, Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, Beijing Forestry University, Beijing, People s Republic of China
    Plant Cell Rep 29:449-60. 2010
    ..Our study also suggested that the PtDrl02 gene 5' untranslated region, as well as a Populus WRKY transcription factor, PtWRKY1, was involved in the regulation of PtDrl02 promoter activities...
  30. pmc Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy?
    Rodrigo B Oliveira
    Nephrology Department, Universidade de Sao Paulo, Sao Paulo, Brazil
    Clin J Am Soc Nephrol 5:286-91. 2010
    ..This short-term 6-wk dose titration study evaluated the effect of two phosphate binders on PTH and FGF23 levels in patients with CKD stages 3 to 4...
  31. pmc ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma
    Yoann Millerioux
    Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, 146 rue Leo Saignat, 33076 Bordeaux, France
    J Biol Chem 287:17186-97. 2012
    ..We concluded that acetate is produced from both ASCT and ACH; however, only ASCT is responsible, together with the F(0)/F(1)-ATP synthase, for ATP production in the mitochondrion...
  32. ncbi Acetate scavenging activity in Escherichia coli: interplay of acetyl-CoA synthetase and the PEP-glyoxylate cycle in chemostat cultures
    Sergio Renilla
    Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Chemistry, University of Murcia, Murcia, Spain
    Appl Microbiol Biotechnol 93:2109-24. 2012
    ....
  33. ncbi Evidence for syntrophic acetate oxidation coupled to hydrogenotrophic methanogenesis in the high-temperature petroleum reservoir of Yabase oil field (Japan)
    Daisuke Mayumi
    Institute for Geo Resources and Environment, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba 305 8567, Japan
    Environ Microbiol 13:1995-2006. 2011
    ..This study demonstrates that syntrophic acetate oxidation is the main methanogenic pathway in a high-temperature petroleum reservoir...
  34. pmc Methyl jasmonate decreases membrane fluidity and induces apoptosis through tumor necrosis factor receptor 1 in breast cancer cells
    Laxmi Yeruva
    Chemistry Department, University of Nevada, Las Vegas, Nevada, USA
    Anticancer Drugs 19:766-76. 2008
    ..In conclusion our results revealed novel-signaling mechanism of MJ in breast cancer cells, indicating that MJ could have potential applications for chemotherapeutic purposes...
  35. ncbi Specific growth rate dependent transcriptome profiling of Escherichia coli K12 MG1655 in accelerostat cultures
    Ranno Nahku
    Tallinn University of Technology, Department of Chemistry, Estonia
    J Biotechnol 145:60-5. 2010
    ..3-0.42h(-1) and acetic acid accumulation from mu=0.34+/-0.01h(-1) allows one to surmise that the acetate utilization operon expression might play an important role in overflow metabolism...
  36. ncbi Detection of active, potentially acetate-oxidizing syntrophs in an anaerobic digester by flux measurement and formyltetrahydrofolate synthetase (FTHFS) expression profiling
    Tomoyuki Hori
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Microbiology 157:1980-9. 2011
    ..These transcripts arose from phylogenetically presumed homoacetogens. The results of this study demonstrate that hitherto unidentified phylotypes of homoacetogens are responsible for syntrophic acetate oxidation in an anaerobic digester...
  37. ncbi Identification of a methyl jasmonate-responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain
    J Rouster
    Carlsberg Research Laboratory, Copenhagen, Denmark
    Plant J 11:513-23. 1997
    ....
  38. ncbi Methanogenic pathway and community structure in a thermophilic anaerobic digestion process of organic solid waste
    Daisuke Sasaki
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    J Biosci Bioeng 111:41-6. 2011
    ..These results imply that the microbial community in the thermophilic degrading process of organic solid waste consists exclusively of unidentified bacteria, which efficiently remove acetate through a non-aceticlastic oxidative pathway...
  39. pmc Bacterial protection of beetle-fungus mutualism
    Jarrod J Scott
    Department of Bacteriology, University of Wisconsin Madison, WI 53706, USA
    Science 322:63. 2008
    ....
  40. pmc Functional characterization of the Sinorhizobium meliloti acetate metabolism genes aceA, SMc00767, and glcB
    J A Ramírez-Trujillo
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Av Universidad 2001, Cuernavaca, Morelos 62210, Mexico
    J Bacteriol 189:5875-84. 2007
    ..Alfalfa plants infected with the aceA and glcB mutants were not impaired in nodulation or nitrogen fixation, and so the glyoxylate cycle is not required in the Rhizobium-legume symbiosis...
  41. ncbi A randomized intervention of montelukast for post-bronchiolitis: effect on eosinophil degranulation
    Chang Keun Kim
    Department of Pediatrics and Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    J Pediatr 156:749-54. 2010
    ..To investigate the effect of montelukast on eosinophil degranulation and recurrent wheezing episodes in post-respiratory syncytial virus (RSV) bronchiolitis...
  42. pmc A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila
    Thomas Chertemps
    Universite Pierre et Marie Curie, UMR, Physiologie de l Insecte, Signalisation et Communication, Paris, France
    BMC Biol 10:56. 2012
    ..As Est-6 is also known to hydrolyze cVA in vitro and is expressed in the main olfactory organ, the antenna, we tested here its role in olfaction as a putative odorant-degrading enzyme...
  43. ncbi Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by-products
    Michael J Plewa
    Department of Crop Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Environ Mol Mutagen 51:871-8. 2010
    ..In addition, these data aid in prioritizing DBPs and their related compounds for future in vivo toxicological studies and risk assessment...
  44. ncbi The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abies
    Tao Zhao
    Ecological Chemistry Group, Department of Chemistry, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
    Phytochemistry 71:1332-41. 2010
    ..Thus, terpene composition in the stem bark may be related to resistance of Norway spruce against I. typographus and C. polonica...
  45. ncbi Acetate-dependent photoheterotrophic growth and the differential requirement for the Calvin-Benson-Bassham reductive pentose phosphate cycle in Rhodobacter sphaeroides and Rhodopseudomonas palustris
    Rick Laguna
    Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
    Arch Microbiol 193:151-4. 2011
    ..Each pathway, therefore, also dictates at what point, CO(2) and reductant are consumed, thereby determining the requirement for the Calvin-Benson-Bassham reductive pentose phosphate cycle...
  46. ncbi Clostridium ultunense sp. nov., a mesophilic bacterium oxidizing acetate in syntrophic association with a hydrogenotrophic methanogenic bacterium
    A Schnurer
    Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Int J Syst Bacteriol 46:1145-52. 1996
    ..A 16S rRNA sequence analysis revealed that strain BST was a member of a new species of the genus Clostridium. We propose the name Clostridium ultunense for this organism; strain BS is the type strain of C. ultunense...
  47. pmc The coronatine-insensitive 1 mutation reveals the hormonal signaling interaction between abscisic acid and methyl jasmonate in Arabidopsis guard cells. Specific impairment of ion channel activation and second messenger production
    Shintaro Munemasa
    Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Plant Physiol 143:1398-407. 2007
    ....
  48. pmc The G-protein gamma subunit gpc-1 of the nematode C.elegans is involved in taste adaptation
    Gert Jansen
    MGC Department of Cell Biology and Genetics and Centre for Biomedical Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    EMBO J 21:986-94. 2002
    ..Our finding that G proteins, OSM-9 and ADP-1 are involved in taste adaptation offer the first molecular insight into this process...
  49. ncbi The enzymic interconversion of acetate and acetyl-coenzyme A in Escherichia coli
    T D Brown
    J Gen Microbiol 102:327-36. 1977
    ..An inducible acetyl-CoA synthetase [acetate: CoA ligase (AMP-forming); EC 6.2.1.1] effects this uptake of acetate...
  50. ncbi Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis
    Geert Van Loo
    Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent University, B 9052 Ghent, Belgium
    Mol Endocrinol 24:310-22. 2010
    ..Based on these results, we propose CpdA as a compound with promising antiinflammatory characteristics useful for therapeutic intervention in multiple sclerosis and other neuroinflammatory diseases...
  51. ncbi Early responses in the Arabidopsis-Verticillium longisporum pathosystem are dependent on NDR1, JA- and ET-associated signals via cytosolic NPR1 and RFO1
    Anna Johansson
    Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, Box 7080, 750 07 Uppsala, Sweden
    Mol Plant Microbe Interact 19:958-69. 2006
    ..longisporum resistance...
  52. ncbi Randomized controlled trial evaluating the clinical benefit of montelukast for treating spring seasonal allergic rhinitis
    Janet van Adelsberg
    Merck and Co Inc Rahway, New Jersey, USA
    Ann Allergy Asthma Immunol 90:214-22. 2003
    ..Symptoms of allergic rhinitis are mediated in part by cysteinyl leukotrienes...
  53. pmc Identification and characterization of the first small molecule inhibitor of MDMX
    Damon Reed
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 285:10786-96. 2010
    ..When combined with selective MDM2 inhibitors, SJ-172550 may also be useful for treating tumors that express wild-type p53...
  54. ncbi Syntrophaceticus schinkii gen. nov., sp. nov., an anaerobic, syntrophic acetate-oxidizing bacterium isolated from a mesophilic anaerobic filter
    Maria Westerholm
    Department of Microbiology, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden
    FEMS Microbiol Lett 309:100-4. 2010
    ..An isolate (strain Esp=JCM 16670) with high 16S rRNA gene sequence identity (99%) to syntrophic acetate-oxidizing Clostridium ultunense was also retrieved from the methanogenic digestor...
  55. ncbi Evidence for anaerobic syntrophic acetate oxidation during methane production in the profundal sediment of subtropical Lake Kinneret (Israel)
    B Nüsslein
    Max Planck Institut fur terrestrische Mikrobiologie, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Environ Microbiol 3:460-70. 2001
    ....
  56. pmc Acetate utilization in Lactococcus lactis deficient in lactate dehydrogenase: a rescue pathway for maintaining redox balance
    P Hols
    Microbial Ingredients Section, NIZO Food Research and Wageningen Centre for Food Science, 6710 BA Ede, The Netherlands
    J Bacteriol 181:5521-6. 1999
    ..This novel pathway provides an alternative route for NAD+ regeneration in the absence of lactate dehydrogenase...
  57. pmc High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli
    Hiroko Tsuruta
    Amyris Biotechnologies, Emeryville, California, United States of America
    PLoS ONE 4:e4489. 2009
    ....
  58. pmc Operation of the CO dehydrogenase/acetyl coenzyme A pathway in both acetate oxidation and acetate formation by the syntrophically acetate-oxidizing bacterium Thermacetogenium phaeum
    Satoshi Hattori
    Research Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    J Bacteriol 187:3471-6. 2005
    ....
  59. ncbi Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight
    John D Baxter
    Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0540, USA
    Trends Endocrinol Metab 15:154-7. 2004
    ..Although more study is required, compounds of this class deserve further investigation for treating lipid disorders and obesity...
  60. pmc Transcriptional profiling of sorghum induced by methyl jasmonate, salicylic acid, and aminocyclopropane carboxylic acid reveals cooperative regulation and novel gene responses
    Ron A Salzman
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    Plant Physiol 138:352-68. 2005
    ....
  61. ncbi C6-volatiles derived from the lipoxygenase pathway induce a subset of defense-related genes
    N J Bate
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    Plant J 16:561-9. 1998
    ..These results suggest that C6-volatiles of the LOX pathway act as a wound signal in plants, but result in a moderate plant response relative to MeJA at both the physiological and molecular level...
  62. pmc Acetate oxidation is the dominant methanogenic pathway from acetate in the absence of Methanosaetaceae
    Dimitar Karakashev
    Institute of Environment and Resources DTU, Technical University of Denmark, Building 113, DK 2800 Kgs Lyngby, Denmark
    Appl Environ Microbiol 72:5138-41. 2006
    ..When Methanosaetaceae were not present, acetate oxidation was the dominant methanogenic pathway. Aceticlastic conversion was observed only in the presence of Methanosaetaceae...
  63. ncbi Insect elicitors and exposure to green leafy volatiles differentially upregulate major octadecanoids and transcripts of 12-oxo phytodienoic acid reductases in Zea mays
    Jurgen Engelberth
    Center for Chemical Ecology, Department of Entomology, The Pennsylvania State University, University Park, PA 16802, USA
    Mol Plant Microbe Interact 20:707-16. 2007
    ..The physiological implications of these findings in the context of plant-insect interactions are discussed...
  64. ncbi Methanosaeta, the forgotten methanogen?
    Kerry S Smith
    Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634 0318, USA
    Trends Microbiol 15:150-5. 2007
    ..Thus, genome analysis of Msa. thermophila presents new research avenues for this forgotten methanogen and reminds us of the questions that still remain unanswered about aceticlastic methanogenesis in both Methanosaeta and Methanosarcina...
  65. ncbi A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis
    Pieter Dewint
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    J Immunol 180:2608-15. 2008
    ..Therefore, we conclude that GR monomers are sufficient for inhibition of inflammation in vivo...
  66. ncbi Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures
    Y Yukimune
    Bioscience Laboratory, Mitsui Petrochemical Industries, Ltd, Yamaguchi, Japan
    Nat Biotechnol 14:1129-32. 1996
    ..These results suggest that these two regions of methyl jasmonate are important for promoting the production of paclitaxel and related taxanes in Taxus cell cultures...
  67. pmc Arabidopsis vegetative storage protein is an anti-insect acid phosphatase
    Yilin Liu
    Department of Entomology, Texas A and M University, College Station, TX 77843, USA
    Plant Physiol 139:1545-56. 2005
    ..Collectively, we conclude that AtVSP2 is an anti-insect protein and that its defense function is correlated with its acid phosphatase activity...
  68. pmc The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling
    Derek V Henley
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:1702-6. 2009
    ..The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression...
  69. ncbi Enzymatic mechanisms of ethanol oxidation in the brain
    Sergey M Zimatkin
    Grodno State Medical University, Grodno, Belarus
    Alcohol Clin Exp Res 30:1500-5. 2006
    ..The objective of the study was to determine the contribution of the different enzymatic pathways to ethanol oxidation in brain homogenates from mice and rats...
  70. pmc Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice
    Lisen Johansson
    Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine, and Molecular Nutrition Unit, Center for Nutrition and Toxicology, Novum, Karolinska Institute at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:10297-302. 2005
    ..Use of TRbeta and uptake selective agonists such as GC-1 should be further explored as a strategy to improve lipid metabolism in dyslipoproteinemia...
  71. pmc Methyl jasmonate-elicited herbivore resistance: does MeJA function as a signal without being hydrolyzed to JA?
    Jinsong Wu
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans Knoll Strasse 8, Jena, Germany
    Planta 227:1161-8. 2008
    ..From these results, we conclude that the resistance elicited by MeJA treatment is directly elicited not by MeJA but by its de-methylated product, JA...
  72. ncbi Benefits and harms of phosphate binders in CKD: a systematic review of randomized controlled trials
    Sankar D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q7, Cleveland, OH 44122, USA
    Am J Kidney Dis 54:619-37. 2009
    ..Phosphate binders are widely used to control serum phosphorus levels in patients with chronic kidney disease (CKD). We analyzed the effects of phosphate binders on biochemical and patient-level end points in patients with CKD...
  73. ncbi Transcriptome analysis of Arabidopsis roots treated with signaling compounds: a focus on signal transduction, metabolic regulation and secretion
    Dayakar V Badri
    Center for Rhizosphere Biology, Colorado State University, Fort Collins, CO 80523, USA
    New Phytol 179:209-23. 2008
    ..These differences could be correlated to the underground nature of roots and their exposure to higher microbial inoculum rates under natural conditions...
  74. pmc The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control
    Yoann Millerioux
    Centre de Résonance Magnétique des Systèmes Biologiques RMSB, UMR 5536 Université Bordeaux Segalen, CNRS, 146 rue Leo Saignat, 33076, Bordeaux, France
    Mol Microbiol 90:114-29. 2013
    ..We conclude that TDH expression is under control and can be downregulated in response to metabolic perturbations, such as in the PEPCK mutant in which the glycolytic metabolic flux was redirected towards acetate production. ..
  75. pmc Integrating flux balance analysis into kinetic models to decipher the dynamic metabolism of Shewanella oneidensis MR-1
    Xueyang Feng
    Department of Energy, Environmental and Chemical Engineering, Washington University, St Louis, Missouri, USA
    PLoS Comput Biol 8:e1002376. 2012
    ..fluxes in the pentose phosphate pathway and gluconeogenesis were stable in the exponential growth period; and 3. the glyoxylate shunt was up-regulated when acetate became the main carbon source for MR-1 growth...
  76. ncbi Overexpression of allene oxide cyclase promoted tanshinone/phenolic acid production in Salvia miltiorrhiza
    Xiao Ce Gu
    Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People s Republic of China
    Plant Cell Rep 31:2247-59. 2012
    ..These suggest that genetic manipulation of AOC would be helpful for improving the production of valuable secondary metabolites by regulating the biosynthesis of JAs...
  77. pmc Characterization and functional analysis of the poxB gene, which encodes pyruvate oxidase in Lactobacillus plantarum
    Frederique Lorquet
    Unité de Génétique, Institut des Sciences de la Vie, Universite Catholique de Louvain, 5 Place Croix du Sud, B 1348 Louvain la Neuve, Belgium
    J Bacteriol 186:3749-59. 2004
    ..In agreement with the latter observation, the level of residual pyruvate oxidase activity with maltose limitation (0.2% maltose) was less than 10% of the wild-type level of activity...
  78. ncbi Thermodynamic constraints on methanogenic crude oil biodegradation
    Jan Dolfing
    School of Civil Engineering and Geosciences, Newcastle University, Newcastle upon Tyne, UK
    ISME J 2:442-52. 2008
    ....
  79. ncbi Montelukast as an add-on therapy to inhaled corticosteroids in the treatment of severe asthma in elderly patients
    Andrzej Bozek
    Clinical Department of Internal Disease, Dermatology and Allergology, Silesian University School of Medicine, Zabrze, Poland
    J Asthma 49:530-4. 2012
    ..However, this disease has not been adequately explored in the elderly. This study was performed to determine how the addition of montelukast to antiasthmatic therapy improves the control of severe asthma in elderly patients...
  80. ncbi Interplant communication: airborne methyl jasmonate is essentially converted into JA and JA-Ile activating jasmonate signaling pathway and VOCs emission
    Shigeru Tamogami
    Laboratory of Biologically Active Substances, Department of Biological Production, Akita Prefectural University, Akita 010 0195, Japan
    Biochem Biophys Res Commun 376:723-7. 2008
    ....
  81. ncbi Haloacetic acids in swimming pools: swimmer and worker exposure
    M J Cardador
    Department of Analytical Chemistry, Campus of Rabanales, University of Córdoba, E 14071 Córdoba, Spain
    Environ Sci Technol 45:5783-90. 2011
    ..Finally, exposure estimates indicate that ingestion is the major route of exposure (~94%), followed by inhalation (~5%) and dermal contribution (~1%)...
  82. ncbi Montelukast for the treatment of asthma in the adult population
    Salima Amlani
    McMaster University, Internal Medicine Residency Program, 1200 Main Street West, Hamilton, Ontario, Canada
    Expert Opin Pharmacother 12:2119-28. 2011
    ..Leukotriene receptor antagonists (LTRA), namely montelukast, provide a safe and effective additional anti-inflammatory treatment option. There is particular benefit for patients with asthma and concomitant allergic rhinitis...
  83. pmc New class of HIV-1 integrase (IN) inhibitors with a dual mode of action
    Manuel Tsiang
    Gilead Sciences, Inc, Foster City, California 94404, USA
    J Biol Chem 287:21189-203. 2012
    ..For the first time, tBPQAs were demonstrated to be allosteric inhibitors of HIV-1 IN displaying a dual mode of action: inhibition of IN-viral DNA assembly and inhibition of IN-LEDGF interaction...
  84. pmc Ice shaping properties, similar to that of antifreeze proteins, of a zirconium acetate complex
    Sylvain Deville
    Laboratoire de Synthèse et Fonctionnalisation des Céramiques, UMR3080 CNRS Saint Gobain, Cavaillon, France
    PLoS ONE 6:e26474. 2011
    ..These results suggest that ice-structuring properties are not exclusive to long organic molecules and should broaden the field of investigations and applications of such substances...
  85. ncbi Methyl jasmonate reduces the survival of cervical cancer cells and downregulates HPV E6 and E7, and survivin
    Elad Milrot
    Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Lett 319:31-8. 2012
    ..Our studies point to MJ as an effective anticancer agent against a variety of cervical cancer cells acting through shared and different pathways to induce cell death regardless of the presence of HPV...
  86. pmc Toward homosuccinate fermentation: metabolic engineering of Corynebacterium glutamicum for anaerobic production of succinate from glucose and formate
    Boris Litsanov
    Institut für Bio und Geowissenschaften, IBG 1 Biotechnologie, Forschungszentrum Julich, Julich, Germany
    Appl Environ Microbiol 78:3325-37. 2012
    ..The succinate yield of 1.67 mol/mol glucose is one of the highest currently described for anaerobic succinate producers and was accompanied by a very low level of by-products (0.10 mol/mol glucose)...
  87. ncbi The effect of montelukast on exhaled nitric oxide and lung function in asthmatic children 2 to 5 years old
    Daniel A Straub
    Division of Respiratory Medicine, University Children s Hospital, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Chest 127:509-14. 2005
    ..The study was undertaken to investigate the influence of once-daily treatment with montelukast (Singulair; MSD; Glattbrugg, Switzerland) on levels of exhaled nitric oxide (eNO) and lung function in preschool children with asthma...
  88. ncbi Methyl jasmonate: a plant stress hormone as an anti-cancer drug
    Sharon Cohen
    Department of Clinical Microbiology and Immunology, Sacker Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Phytochemistry 70:1600-9. 2009
    ..In summary, the jasmonates are anti-cancer agents that exhibit selective cytotoxicity towards cancer cells, and thus present hope for the development of cancer therapeutics...
  89. ncbi Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion
    Megumi Omori
    Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1, Shikata cho, Okayama City 700 8558, Japan
    Brain Res 1219:26-31. 2008
    ..01) the proportion of large ASIC3-ir neurons compared to proportions in sham-operated animals. These findings suggest that ASIC3 is associated with hyperalgesia in response to a chemical stimulus in the L5 SNL rat model...
  90. ncbi Patterns of asthma-related health care resource use in children treated with montelukast or fluticasone
    Felicia C Allen-Ramey
    Merck and Co Inc, West Point, PA 19486, USA
    Curr Med Res Opin 22:1453-61. 2006
    ..To examine the impact of controller monotherapy with montelukast or fluticasone on asthma-related health care resource use among children aged 2-14 years old...
  91. ncbi Tepidanaerobacter acetatoxydans sp. nov., an anaerobic, syntrophic acetate-oxidizing bacterium isolated from two ammonium-enriched mesophilic methanogenic processes
    Maria Westerholm
    Department of Microbiology, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Syst Appl Microbiol 34:260-6. 2011
    ..nov. is suggested. The type strain of T. acetatoxydans is Re1(T) (=DSM 21804(T)=JCM 16047(T))...
  92. ncbi Effects of varespladib methyl on biomarkers and major cardiovascular events in acute coronary syndrome patients
    Robert S Rosenson
    Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 56:1079-88. 2010
    ..The purpose of this study was to investigate the effects of varespladib on cardiovascular biomarkers in acute coronary syndrome patients...
  93. ncbi AN N-terminal Smac peptide sensitizes human prostate carcinoma cells to methyl jasmonate-induced apoptosis
    Guosong Jiang
    Department of Urology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
    Cancer Lett 302:37-46. 2011
    ..Thus, blockade of the over-expressed IAPs in cancer cells could yield a potential therapeutic benefit in jasmonates-based chemotherapy...
  94. ncbi Chronic renal failure-induced multiple-organ injury in rats is alleviated by the selective CysLT1 receptor antagonist montelukast
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad, 34668 Istanbul, Turkey
    Prostaglandins Other Lipid Mediat 83:257-67. 2007
    ....
  95. ncbi Fatty acid-derived signals in plants
    Hans Weber
    Gene Expression Laboratory, Ecology Institute, University of Lausanne, Biology Building, CH 1015, Lausanne, Switzerland
    Trends Plant Sci 7:217-24. 2002
    ..They highlight the importance of fatty acid-derived molecules in interspecies communication and in plant defence...
  96. ncbi Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress
    Liang Zhang
    State Key Laboratory of Crop Biology, Shandong Key Laboratory of Crop Biology, Shandong Agricultural University, Taian, Shandong, China
    FEBS J 278:1367-78. 2011
    ..These results increased our understanding of the role of the group C GhMPK2 gene in multiple defense-signaling pathways, including those that are involved in responses to pathogen infection and oxidative stress...
  97. ncbi Bioenergetic models for acetate and phosphate transport in bacteria important in enhanced biological phosphorus removal
    Luke C Burow
    Advanced Wastewater Management Centre, The University of Queensland, St Lucia, QLD 4072, Australia
    Environ Microbiol 10:87-98. 2008
    ..Activity of a high-velocity Pst system in Accumulibacter spp. may further explain its ability to compete strongly in EBPR...
  98. ncbi Candidatus 'Brocadia fulgida': an autofluorescent anaerobic ammonium oxidizing bacterium
    Boran Kartal
    Department of Microbiology, Institute for Water and Wetland Research, Radboud University Nijmegen, Nijmegen, The Netherlands
    FEMS Microbiol Ecol 63:46-55. 2008
    ..It is the only known anammox species exhibiting this feature. The autofluorescent extracellular polymeric substance had two excitation (352 and 442 nm) and two emission (464 and 521 nm) maxima...
  99. pmc Activation of the T1 neuronal circuit is necessary and sufficient to induce sexually dimorphic mating behavior in Drosophila melanogaster
    David S Ronderos
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 30:2595-9. 2010
    ..These findings demonstrate that the T1/Or67d circuit is necessary and sufficient to mediate sexually dimorphic courtship behaviors...
  100. ncbi Syntrophic acetate oxidation under thermophilic methanogenic condition in Chinese paddy field soil
    Junpeng Rui
    College of Resources and Environmental Sciences, China Agricultural University, Beijing, China
    FEMS Microbiol Ecol 77:264-73. 2011
    ..Thus, acetate was converted to CH(4) and CO(2) through aceticlastic methanogenesis at 25°C, while syntrophic acetate oxidation occurred at 50°C...
  101. ncbi The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus
    Hongtao Zhang
    Institute of Biology, Leiden University, Sylvius Laboratory, PO Box 9505, 2300 RA Leiden, The Netherlands
    Plant J 67:61-71. 2011
    ....

Research Grants72

  1. Small Cell-Penetrating Glyco-Decoys Sidetrack Selectin Ligand Biosynthesis
    Khushi L Matta; Fiscal Year: 2013
    ..In another approach, we focused on synthesis of modified analogs of monosaccharides such as 4-fluoro-GlcNAc acetates and 4-fluoro-GalNAc acetates as cell-penetrating metabolic inhibitors of the selection ligand assembly enzymes...
  2. REACTIVITY AND SELECTIVITY OF REACTIONS IN POLAR MEDIA
    PAUL GRIECO; Fiscal Year: 2002
    ..and lithium phosphates wherein the anions are chiral in hopes of catalyzing substitution reactions of allylic and benzylic acetates via single diastereomeric ion pairs which undergo facial discrimination in the attack by a nucleophile.
  3. CHARACTERIZATION OF HUMAN CARCINOMA T & TN AUTOANTIGENS
    GEORG SPRINGER; Fiscal Year: 1991
    ..To determine OS composition by hydrolysis, enzymatically, colorimetrically and by gas C (GC) of alditol acetates, and structures using glycosidases, permethylation, GC-mass spectrometry (GC/MS) & NMR...
  4. METABOLIC ACTIVATION OF UNSUBSTITUTED HYDROXAMIC ACID
    MEI SIE LEE; Fiscal Year: 1990
    ..Therefore, it is hypothesized that 1) hydroxamic acids and their O-acetates are potential environmental genotoxins for humans because of their activation by oxidative enzymes, and 2) the ..
  5. ABI QSTAR XL Q-Q TOF Mass Spectrometer
    BRADLEY HAYES; Fiscal Year: 2004
    ..Gas chromatography with mass spectrometric detection of partially methylated alditol acetates suffers from similar limitations...
  6. HUMAN CERVICAL MUCIN: OLIGOSACCHARIDE STRUCTURE
    EDWARD YUREWICZ; Fiscal Year: 1980
    ..Structural analyses will utilize sequential degradations with exoglycosidases and identification of methylated alditol acetates by gas liquid chromatography/mass spectroscopy.
  7. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  8. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  9. CARE Network-UCSD Clinical Center
    Robert Zeiger; Fiscal Year: 2008
    ..abstract_text> ..
  10. PASADENA: Ultra-fast Carbon 13 Imaging for Early Diagnosis of Cancer
    Pratip Bhattacharya; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. 13C and 15N MRS Study of glutamate control in epilepsy
    Brian Ross; Fiscal Year: 2009
    ..Together these studies will contribute to a better understanding of the regulatory events of the GLN/GLU cycle in KA and increase potential to replace surgical management of temporal lobe epilepsy. ..
  12. ORGANOMETALLIC SYNTHESES OF BIOACTIVE COMPOUNDS
    LOUIS HEGEDUS; Fiscal Year: 2003
    ..abstract_text> ..
  13. ENZYMOLOGY OF ACETOTROPHIC METHANOGENESIS
    JAMES FERRY; Fiscal Year: 2003
    ..The results are expected to contribute not only to a deeper understanding of the acetate fermentation pathway, but more importantly to the broader field of anaerobic microbiology and beyond. ..
  14. LIGAND PHARMACOLOGY OF ESTROGEN RECEPTORS
    Thomas Scanlan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  15. New Ligands for Radioimmunotherapy and MRI of Cancer
    Hyun Soon Chong; Fiscal Year: 2006
    ..The results of the proposed research will contribute to the development of better drugs for both MRI and RIT, which will greatly enhance clinical exploration of both modalities, and directly benefit cancer patients. ..
  16. Mixture Toxicity - Evaluation of an Improved Methodology
    DOUGLAS DAWSON; Fiscal Year: 2008
    ..Environmental releases of these chemicals are possible, which could also affect public health. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  17. MECHANISMS OF SKELETAL RECONSTITUTION AFTER LACTATION
    Scott Miller; Fiscal Year: 2004
    ..abstract_text> ..
  18. OLFACTORY FUNCTION IN GENE-TARGETED MICE
    Burton Slotnick; Fiscal Year: 2002
    ..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
  19. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  20. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  21. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  22. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  23. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  24. Multiplexed pathogen detection by on-chip amplification
    Darrell Chandler; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  25. Integrated, on-chip RT-MME-PCR for influenza diagnostics; Phase 1 = sample prepar
    Darrell Chandler; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular Cells
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..Results will clarify the interaction of genetics and EDAs as cause of cryptorchidism. [unreadable] [unreadable] [unreadable]..
  27. Diagnostic protein array for respiratory infections
    Darrell Chandler; Fiscal Year: 2008
    ..The underlying platform developed herein will likewise find broad application in many areas of disease surveillance, with an emphasis on point-of-use applications. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  28. Neuronal and Circuitry Mechanisms of Epileptogenesis in a Complex in Vitro Model
    Dennis Turner; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. The genetics of cardiac aging in Drosophila melanogaster
    Giovanni Paternostro; Fiscal Year: 2002
    ..Our long-term aims are to obtain a complete picture of the genetics of cardiac aging in Drosophila and to use this to stimulate investigations in vertebrates. ..
  30. FOLATE AMINOBORONIC ACIDS AS TARGETED ANTI-CANCER AGENTS
    VENKATRAM MEREDDY; Fiscal Year: 2008
    ..These molecules could act as targeted molecules for folate receptor overexpressing cancer lines and may be useful for especially for the treatment of metastasized and relapsed cancers. [unreadable] [unreadable] [unreadable]..
  31. Pneumocystis Biochemistry: Ubiquinones
    EDNA KANESHIRO; Fiscal Year: 2002
    ..carinii CoQ biosynthesis and growth in axenic cultures, and (4) develop atovaquone-resistant P. carinii populations to evaluate CoQ synthesis in sensitive and resistant organisms. ..
  32. Allenic [2 + 2 + 1] Reactions Enabling Syntheses of Natural Products with 7-Membe
    Kay M Brummond; Fiscal Year: 2010
    ..The rapid isomerization of allenol acetates under the Rh(I)-catalyzed conditions will be explored for the enantioselective preparation of -acetoxy ..
  33. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
  34. ROLE OF CHROMATIN IN HIV TRANSCRIPTIONAL REGULATION
    ERIC M VERDIN; Fiscal Year: 2010
    ..These experiments have the potential of identifying novel factors mediating HIV transcriptional regulation that could be targeted therapeutically in the future. ..
  35. Oxidative Stress and Anti-Inflammatory Lipids in Airway Disease
    Bruce D Levy; Fiscal Year: 2010
    ..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..
  36. MODULATION OF T CELL FUNCTIONS BY HIV1 TAT
    Eric Verdin; Fiscal Year: 2001
    ..These studies will further define the role of Tat as modulator of T cell differentiated functions and establish its role in HIV pathogenesis. ..
  37. Chemistry and Biology of Antitumor Natural Products
    JEF KAREL DE BRABANDER; Fiscal Year: 2010
    ..We will develop efficient syntheses of these natural products and synthetic analogs to identify anticancer leads for the treatment of human tumor cancers. ..
  38. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  39. Sterol Metabolism in Pneumocystis
    EDNA KANESHIRO; Fiscal Year: 2009
    ....
  40. AMPHIPATHIC ORAL CHELATORS AND RADIONUCLIDE CONTAMINATION
    Scott Miller; Fiscal Year: 2008
    ..Because the pharmacology and toxicology of PACA chelators, such as DTPA and EDTA, are quite well understood, the development pathway of the related TT- based chelators may proceed rapidly. ..
  41. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2006
    ..abstract_text> ..
  42. Exercise as an Anti-Inflammatory Therapy for Asthma
    John Mastronarde; Fiscal Year: 2007
    ..These results will have a major impact in defining the role of exercise therapy in the treatment of asthma, which may be revealed as a "new" anti-inflammatory treatment for asthma. ..
  43. OLFACTORY CODING
    Burton Slotnick; Fiscal Year: 2003
    ..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
  44. SCALING THE REINFORCING VALUE OF CIGARETTE SMOKE
    Jed Rose; Fiscal Year: 2003
    ..The results will lead to a better understanding of the role of pharmacologic and sensory/behavioral cues in nicotine addiction and smoking cessation. ..
  45. Acetate and ATP binding in acetyl-CoA synthetase
    Kerry Smith; Fiscal Year: 2004
    ..Alteration of these residues by site-directed mutagenesis followed by kinetic and biochemical characterization of the resulting variants will delineate their role in substrate binding. ..
  46. Neuro-Immune Interactions in Developing Airways
    Gary Larsen; Fiscal Year: 2005
    ..These studies of developmental airway biology in mammalian species allow definition of neuro-immune mechanisms that may have relevance to events that occur in infants and small children. ..
  47. A New In Vitro Model for HIV Latency
    Eric Verdin; Fiscal Year: 2004
    ..These studies should further establish the validity of our model for the study of HIV latency in patients. ..
  48. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
    ....
  49. RELEASE CHANNEL ISOFORMS AND LOCAL CALCIUM SIGNALING
    Natalia Shirokova; Fiscal Year: 2003
    ..Proposed studies will greatly advanced our knowledge of their functioning, which in turn could improve our understanding of their role in decease. ..
  50. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2004
    ....
  51. NOVEL LUNG DERIVED CHALONES--BIOSYNTHESIS AND BIOACTIONS
    Bruce Levy; Fiscal Year: 2002
    ..End of Abstract) ..
  52. SYNTHESIS OF DIAZONAMIDES
    Philip Magnus; Fiscal Year: 2004
    ..Part of the synthetic studies will involve the generation of persistent radical intermediates that should add to pi-deficient heterocycles and form the key central hindered bond present in the diazonamides. ..
  53. Lifespan Neuronal/Glial Metabolism During Hypoglycemia
    Dennis Turner; Fiscal Year: 2003
    ..These in vitro slice models of hypoglycemia will contribute greatly to the understanding of neuronal metabolism, and particularly the metabolic interactions between neurons and glia as a function of lifespan. ..
  54. ACYCLIC STEREOCONTROL IN RADICAL REACTIONS
    MUKUND SIBI; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. Function of FMRP in the Mouse Olfactory System
    John Larson; Fiscal Year: 2007
    ..Such new information would be vital for evaluating novel treatment strategies for a class of developmental disabilities. [unreadable] [unreadable]..
  56. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..
  57. GENETIC EFFECTS-FOLATE-DEPENDENT ONE-CARBON METABOLISM
    JESSE GREGORY; Fiscal Year: 2004
    ..In total, these studies will yield new functional data regarding the effects of folate deficiency, and the influence of common polymorphism of MTHFR. ..
  58. NINTH INTERNATIONAL WORKSHOPS ON OPPORTUNISTIC PEOTISTS (IWOP-9)
    EDNA KANESHIRO; Fiscal Year: 2006
    ..As in several IWOP meetings in the past, the 2006 Workshops will be held jointly with the annual meetings of the International Society of Protistologists ( formerly Society of Protozoologists). ..
  59. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2004
    ..Overall, this: exploratory: study may open the door for the use of iron chelator nanoparticle systems to target diseased organs for iron chelation therapy. ..
  60. Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism
    Carlos Camargo; Fiscal Year: 2008
    ..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
  61. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
    ....
  62. SCLERODERMA LUNG STUDY
    Robert Wise; Fiscal Year: 2003
    ..abstract_text> ..
  63. CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA
    ROBERT LEMANSKE; Fiscal Year: 2001
    ..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
  64. The Placebo Effect in Asthma
    Robert Wise; Fiscal Year: 2005
    ..Understanding the placebo response can lead to improvements in research and treatment of asthma. ..
  65. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
  66. Study of the Strength of CH-Y (Y =O,N)and XH-pi (X=N,O,S) Interactions
    BENJAMIN GUNG; Fiscal Year: 2006
    ..The understanding of these weak interactions is essential for rational drug design and lead optimization. [unreadable] [unreadable]..
  67. CARE Network - Madison Clinical Center
    ROBERT LEMANSKE; Fiscal Year: 2008
    ..abstract_text> ..
  68. Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children
    Carlos Camargo; Fiscal Year: 2008
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of asthma. [unreadable] [unreadable] [unreadable] [unreadable]..
  69. Clinical Trial of Acid Reflux Therapy in Asthma
    Robert Wise; Fiscal Year: 2007
    ..Pre-specified subgroup analyses will be conducted to determine if there are clinical or demographic characteristics that predict benefit from treatment of GERD in asthma. ..
  70. Treatment of Severe Persistent Asthma
    ROBERT LEMANSKE; Fiscal Year: 2007
    ..abstract_text> ..