Genomes and Genes
Summary: A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells.
Publications245 found, 100 shown here
- Regulation of mitochondrial NADP+-dependent isocitrate dehydrogenase activity by glutathionylationIn Sup Kil
Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Korea
J Biol Chem 280:10846-54. 2005..HEK293 cells and intact respiring mitochondria treated with oxidants inducing GSH oxidation such as H(2)O(2) or diamide showed a decrease in IDPm activity and the accumulation of glutathionylated enzyme...
- Identification of a critical region in the Drosophila ryanodine receptor that confers sensitivity to diamide insecticidesYong Tao
Department of Microbiology and Biotechnology, Institute of Microbiology, Chinese Academy of Sciences, 1 West Beichen Road, Chaoyang District, Beijing 100101, China
Insect Biochem Mol Biol 43:820-8. 2013..of the Drosophila C-terminus with that from Meloidogyne results in a functional RyR which lack sensitivity to diamide insecticides...
- The extracytoplasmic function-type sigma factor SigM of Corynebacterium glutamicum ATCC 13032 is involved in transcription of disulfide stress-related genesDiana Nakunst
Institut für Genomforschung und Systembiologie, Centrum für Biotechnologie, Universitat Bielefeld, 33501 Bielefeld, Germany
J Bacteriol 189:4696-707. 2007..glutamicum cells more sensitive to heat, cold, and the presence of the thiol oxidant diamide. Transcription of the sigM gene increased under different stress conditions, including heat shock, cold shock, ..
- Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilisTatiana Rochat
INRA, UMR 1319 Micalis, France
Nucleic Acids Res 40:9571-83. 2012..Three quarters of these sites were located near Sigma(A)-dependent promoters, and upon diamide treatment, the fraction of the Spx-RNAP complex increased in parallel with the number and occupancy of DNA sites...
- Diamide triggers mainly S Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureusDierk Christoph Pöther
Institute of Microbiology1 and Institute of Pharmaceutical Biology, 2 Ernst Moritz Arndt University of Greifswald, F L Jahnstr 15, D 17487 Greifswald, Germany
J Bacteriol 191:7520-30. 2009..subtilis after treatment of cells with the disulfide-generating electrophile diamide. S cysteinylation is thought to protect protein thiols against irreversible oxidation to sulfinic and sulfonic ..
- Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilisMontira Leelakriangsak
Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR, USA
Mol Microbiol 67:1108-24. 2008..and the azoreductase encoding yvaB (azoR2) gene in response to thiol-specific stress conditions, such as diamide, catechol and 2-methylhydroquinone (MHQ)...
- Functional analysis of sigH expression in Corynebacterium glutamicumTae Hyun Kim
Graduate School of Biotechnology, Korea University, Anam Dong, Sungbuk Ku, Seoul 136 701, Republic of Korea
Biochem Biophys Res Commun 331:1542-7. 2005..glutamicum cells sensitive to the thiol-specific oxidant diamide. In the sigH mutant strain, the activity of thioredoxin reductase markedly decreased, suggesting that the trxB ..
- Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytesMaddalena Fratelli
Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
Proc Natl Acad Sci U S A 99:3505-10. 2002..To this purpose, we radiolabeled cellular glutathione with (35)S, exposed T cells to oxidants (diamide or hydrogen peroxide), and performed nonreducing, two-dimensional electrophoresis followed by detection of ..
- Global characterization of disulfide stress in Bacillus subtilisLars Ingo Ole Leichert
Institut fur Mikrobiologie, Ernst Moritz Arndt Universitat, 17487 Greifswald, Germany
J Bacteriol 185:1967-75. 2003..To induce disulfide stress, we used the specific thiol oxidant diamide. After addition of 1 mM diamide to an exponentially growing culture, cell growth stopped until the medium was ..
- Modulation of the expression of ryanodine receptor mRNA from Plutella xylostella as a result of diamide insecticide applicationLina Sun
Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
Gene 511:265-73. 2012..With the development of diamide insecticides that exhibit a novel mode of action on the RyRs from Lepidoptera, research on insect RyRs has become ..
- Effects of cyantraniliprole, a novel anthranilic diamide insecticide, against Asian citrus psyllid under laboratory and field conditionsSiddharth Tiwari
Entomology and Nematology Department, Citrus Research and Education Center, University of Florida, Lake Alfred, FL 33850, USA
Pest Manag Sci 69:1066-72. 2013..citri has been documented. There is an urgent need to develop and integrate novel tools for the successful management of D. citri and also to prevent the development of insecticide resistance...
- Reactive oxygen species induced by diamide inhibit insulin-induced ATP-sensitive potassium channel activation in cultured vascular smooth muscle cellsKazuaki Mawatari
Department of Metabolism and Nutrition, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
Asia Pac J Clin Nutr 17:162-6. 2008..Here we examined the effects of ROS induced by a thol-oxidizing agent, diamide, on the insulin signalling pathway and KATP channel activities in cultured VSMCs (A10 cells)...
- Tolerance of the mouse sperm nuclei to freeze-drying depends on their disulfide statusTakehito Kaneko
Institute for Biogenesis Research, Department of Anatomy and Reproductive Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96822, USA
Biol Reprod 69:1859-62. 2003..However, immature spermatozoa became resistant to freeze-drying after their treatment with diamide, which oxidizes free -SH groups...
- Staphylococcus aureus NfrA (SA0367) is a flavin mononucleotide-dependent NADPH oxidase involved in oxidative stress responseKarin Streker
Institut für Molekulare Infektionsbiologie, Rontgenring 11, D 97070 Wurzburg, Germany
J Bacteriol 187:2249-56. 2005..Transcription was strongly induced by ethanol, diamide, and nitrofurantoin. Hydrogen peroxide induced nfrA transcription only at high concentrations...
- In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbanceSandra Moriceau
INSERM U845, Necker Hospital, Paris, France
J Innate Immun 2:260-6. 2010..b>Diamide, a direct thiol-oxidizing agent, potentiated PMN apoptosis in controls and CF patients, resulting in similar ..
- RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeastTae Soo Kim
Department of Biological Chemistry and Molecular Pharmacology, Harvard University, 240 Longwood Avenue, Boston, MA 02115, USA
Genome Biol 11:R75. 2010..However, changes in mRNA abundance reflect the combined effect of changes in RNA production, processing, and degradation, and thus, mRNA levels provide an occluded view of transcriptional regulation...
- Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiologyIstvan Pocsi
Department of Microbiology and Biotechnology, Faculty of Science, University of Debrecen, PO Box 63, H 4010 Debrecen, Hungary
BMC Genomics 6:182. 2005....
- Dual negative control of spx transcription initiation from the P3 promoter by repressors PerR and YodB in Bacillus subtilisMontira Leelakriangsak
OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97229, USA
J Bacteriol 189:1736-44. 2007..Induction of spx transcription in response to treatment with the thiol-specific oxidant diamide is the result of transcription initiation at the P(3) promoter located upstream of the spx coding sequence...
- Use of diamide-acridine orange fluorescence staining to detect aberrant protamination of human-ejaculated sperm nucleiHaruo Katayose
Department of Obstetrics and Gynecology, School of Medicine, Fukushima Medical University, Fukushima, Japan
Fertil Steril 79:670-6. 2003..To investigate the influence of human sperm nuclear chromatin on fertilization...
- Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilisHaike Antelmann
Institute of Microbiology, Ernst Moritz Arndt University of Greifswald, F L Jahn Str 15, D 17487 Greifswald, Germany
Expert Rev Proteomics 5:77-90. 2008..Catechol, 2-MHQ and diamide displayed a common mode of action, as revealed by the induction of the thiol-specific oxidative stress response...
- Genomic expression programs in the response of yeast cells to environmental changesA P Gasch
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
Mol Biol Cell 11:4241-57. 2000..temperature shocks, hydrogen peroxide, the superoxide-generating drug menadione, the sulfhydryl-oxidizing agent diamide, the disulfide-reducing agent dithiothreitol, hyper- and hypo-osmotic shock, amino acid starvation, nitrogen ..
- The sigmaR regulon of Streptomyces coelicolor A32 reveals a key role in protein quality control during disulphide stressDimitris Kallifidas
Department of Chemistry and Biochemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
Microbiology 156:1661-72. 2010b>Diamide is an artificial disulphide-generating electrophile that mimics an oxidative shift in the cellular thiol-disulphide redox state (disulphide stress)...
- Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5BSteven R LaPlante
Department of Chemistry, Boehringer Ingelheim Canada Ltd, 2100 Cunard St, Laval, Quebec, Canada, H7S2G5
J Am Chem Soc 132:15204-12. 2010....
- The redox-sensing regulator YodB senses quinones and diamide via a thiol-disulfide switch in Bacillus subtilisBui Khanh Chi
Institute for Microbiology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
Proteomics 10:3155-64. 2010..the azoreductase AzoR1, the nitroreductase YodC and the redox-sensing regulator Spx in response to quinones and diamide in Bacillus subtilis...
- Expression of macrophage inflammatory protein 1 alpha in the endothelial cells exposed to diamideLimin Yang
Department of Pathology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
J Huazhong Univ Sci Technolog Med Sci 23:219-22, 233. 2003In order to study whether the endothelial cells (ECs) with lipid peroxidation induced by diamide can express and secrete macrophage inflammatory protein 1 alpha (MIP-1 alpha), the expression of MIP-1 alpha protein in the cells was ..
- Ineffective GSH regeneration enhances G6PD-knockdown Hep G2 cell sensitivity to diamide-induced oxidative damageLi Ping Gao
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, People s Republic of China
Free Radic Biol Med 47:529-35. 2009..Hep G2 cells expressing shRNA against G6PD (Gi) were more susceptible to diamide-induced cytotoxicity than control cells expressing scrambled control shRNA (Sc)...
- A novel NADPH:diamide oxidoreductase activity in arabidopsis thaliana P1 zeta-crystallinJ Mano
Research Institute for Food Science, Kyoto University, Uji, Japan
Eur J Biochem 267:3661-71. 2000..of Arabidopsis thaliana, known to confer tolerance toward the oxidizing drug 1,1'-azobis(N, N-dimethylformamide) (diamide) to yeast [Babiychuk, E., Kushnir, S., Belles-Boix, E., Van Montagu, M. & Inzé, D. (1995) J. Biol. Chem...
- Effector-induced Syk-mediated phosphorylation in human erythrocytesLuciana Bordin
Department of Biological Chemistry, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
Biochim Biophys Acta 1745:20-8. 2005..tyrosine phosphorylated following treatment of intact cells with protein tyrosine phosphatase inhibitors such as diamide, pervanadate, vanadate, or N-ethylmaleimide (NEM)...
- Requirement of the zinc-binding domain of ClpX for Spx proteolysis in Bacillus subtilis and effects of disulfide stress on ClpXP activityYing Zhang
Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, 20000 NW Walker Rd, Beaverton, OR 97006, USA
J Bacteriol 189:7669-80. 2007..The effect of disulfide stress on ClpXP activity was examined using the thiol-specific oxidant diamide. ClpXP-catalyzed degradation of either Spx or a green fluorescent protein derivative bearing an SsrA tag ..
- Arabidopsis thaliana NADPH oxidoreductase homologs confer tolerance of yeasts toward the thiol-oxidizing drug diamideE Babiychuk
Laboratorium voor Genetica, Universiteit Gent, Belgium
J Biol Chem 270:26224-31. 1995..approximately 10(5) primary transformants were subjected to a tolerance screen toward the thiol-oxidizing drug diamide, which depletes the reduced glutathione in the cell. Four types of Arabidopsis cDNAs were isolated...
- Flexibility in the receptor-binding domain of the enzymatic colicin E9 is required for toxicity against Escherichia coli cellsChristopher N Penfold
School of Molecular Medical Sciences and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
J Bacteriol 186:4520-7. 2004..On oxidation with diamide, no significant biological activity was seen with the ColE9 L359C-F412C and the ColE9 Y324C-L447C mutant proteins;..
- Regulation of cAMP-dependent protein kinase activity by glutathionylationKenneth M Humphries
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, The University of California, San Diego, La Jolla, California 92093 0654, USA
J Biol Chem 277:43505-11. 2002..In vitro studies demonstrated the susceptibility of kinase activity to the sulfhydryl oxidant diamide, which inhibited by promoting an intramolecular disulfide bond between cysteines 199 and 343...
- Oxidative stress inhibits ionomycin-mediated cell death in cortical neuronsAdrian T McCollum
Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
J Neurosci Res 76:104-9. 2004..To test this hypothesis, cultured rat cortical neurons were treated with the oxidizing agent diamide or doxorubicin in the presence or absence of the calcium ionophore ionomycin...
- Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugationTom S Chan
Faculty of Pharmacy, University of Toronto, 19 Russell St Rm 522, Toronto, Ont, Canada M5S 2S2
Biochem Biophys Res Commun 317:149-56. 2004..These data suggest that GSH depletion can stimulate ascorbate synthesis independently of glucose synthesis and that hepatocytes can direct glycogenolysis towards ascorbate synthesis during GSH conjugation...
- Regulation of annexin A2 by reversible glutathionylationJennifer F Caplan
Cancer Biology Research Group, Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4N1, Canada
J Biol Chem 279:7740-50. 2004..Oxidation of AIIt by diamide resulted in a time- and concentration-dependent loss of the ability of AIIt to interact with phospholipid ..
- Dual effect of oxidative stress on NF-kappakB activation in HeLa cellsMi Sun Byun
Department of Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Korea
Exp Mol Med 34:332-9. 2002..such conflicting effect of oxidative stress on NF- kappakB activation, HeLa cells were incubated with H(2)O(2) or diamide and TNF-induced expression of NF-kappaB reporter gene was measured...
- Actin S-glutathionylation: evidence against a thiol-disulphide exchange mechanismIsabella Dalle-Donne
Department of Biology, University of Milan, Milan, Italy
Free Radic Biol Med 35:1185-93. 2003..Instead, actin with the exposed cysteine thiol activated by diamide or 5,5'-dithiobis(2-nitrobenzoic acid) reacts with physiological levels of GSH, incorporating about 0...
- Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cellsTherese Söderdahl
Division of Biochemical Toxicology, Karolinska Institutet, Stockholm Sweden
FASEB J 17:124-6. 2003..initial visualization of the compartmentalization of protein-GSH mixed disulfides formed in A549 cells exposed to diamide. Discontinuous staining was again evident, with heavy staining in membrane blebs and in the nuclear region...
- Targeted disruption of specific steps of the ubiquitin-proteasome pathway by oxidation in lens epithelial cellsMathew R Hosler
Department of Biochemistry and Molecular Biology, 185 South Orange Avenue, Newark, NJ 07101, USA
Int J Biochem Cell Biol 35:685-97. 2003..several steps of the ubiquitin-proteasome pathway with an alternative agent: the thiol-specific oxidant, diamide. The 20S core proteasome, de-ubiquitinating, and ATP-dependent 26S proteasome activities all showed decreases 10 ..
- Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stressStefania Filosa
IGB Adriano Buzzati Traverso CNR, Via G Marconi 12, 80125 Napoli, Italy
Biochem J 370:935-43. 2003..Moreover, bacterial G6PD can substitute for the human enzyme, strongly suggesting that a relatively simple mechanism of enzyme kinetics underlies this phenomenon...
- MRP1-transfected cells do not show increased resistance against oxidative stressAneta Balcerczyk
Department of Molecular Biophysics, University of Lodz, 90 237 Lodz, Poland
Free Radic Res 37:189-95. 2003..Cells overexpressing MRP1 did not show increased resistance to tert-butyl hydroperoxide, diamide, paraquat, menadione, dichromate and carmustine as estimated by cell survival and DNA damage assessed by comet ..
- Thiol oxidation-mediated cell death in Aplysia cultured sensory neuronsDeok Jin Chang
National Research Laboratory, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Kwanak gu, Seoul 151 742, South Korea
Brain Res 1007:71-7. 2004..In this study, we found that a thiol oxidant, diamide, induced morphological changes such as cell swelling, membrane blebbing, and chromatin condensation in Aplysia ..
- Redox sensitivity of the ryanodine receptor interaction with FK506-binding proteinSpyros Zissimopoulos
Wales Heart Research Institute, Department of Cardiology, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom
J Biol Chem 282:6976-83. 2007..6, we found that the sulfydryl-oxidizing agents, H(2)O(2) and diamide, result in diminished RyR2-FKBP12.6 binding...
- Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxiaYe Shih Ho
Institute of Environmental Health Sciences and Department of Biochemistry and Molecular Biology, Wayne State University, Detroit, MI 48201, USA
Free Radic Biol Med 43:1299-312. 2007..diquat and paraquat, but they were not more susceptible to cell death induced by hydrogen peroxide (H(2)O(2)) and diamide. A deficiency in Grx1 also sensitized MEFs to protein S-glutathionylation in response to H(2)O(2) treatment and ..
- Mitochondrial thioredoxin in regulation of oxidant-induced cell deathYan Chen
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
FEBS Lett 580:6596-602. 2006..Results showed that mtTrx was oxidized after exposure to peroxides and diamide. Overexpression of mtTrx protected against diamide-induced oxidation and cytotoxicity...
- Transcriptional activation of dehalorespiration. Identification of redox-active cysteines regulating dimerization and DNA bindingStelian M Pop
Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
J Biol Chem 281:26382-90. 2006..When incubated with oxygen or diamide, CprK undergoes inactivation; subsequent treatment with dithiothreitol restores activity...
- Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stressRanieri Rossi
Department of Neuroscience, Pharmacology Section, University of Siena, Siena, Italy
Clin Chem 52:1406-14. 2006..We evaluated the importance of correct sample handling during the preanalytical phase for GSH, GSSG, and PSSG measurement...
- Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) currentKlara Susankova
Department of Cellular Neurophysiology, Institute of Physiology AS CR, Videnska 1083, 142 20 Prague 4, Czech Republic
Mol Pharmacol 70:383-94. 2006..The sensitizing effects of the membrane-permeable oxidizing agents diamide (1 mM), chloramine-T (1 mM), and the copper-o-complex (100:400 microM) were not reversed by washout, consistent ..
- Enhanced oxidative stress by L-ascorbic acid within cells challenged by hydrogen peroxideYoko Inai
Department of Biochemistry, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 0012, Japan
J Nutr Sci Vitaminol (Tokyo) 51:398-405. 2005....
- Band 3 tyr-phosphorylation in normal and glucose-6-phospate dehydrogenase-deficient human erythrocytesLuciana Bordin
Department of Biological Chemistry, University of Padova, Viale G Colombo, 3, 35121, Padova, Italy
Mol Membr Biol 22:411-20. 2005..show that this sensitivity is connected to an early membrane band 3 Tyr-phosphorylation in the presence of diamide. However, since both Syk, and Lyn kinases, and SHP-2 phosphatase, mostly implicated in the band 3 P-Tyr level ..
- Fluorescence thiol modification assay: oxidatively modified proteins in Bacillus subtilisFalko Hochgräfe
Institut fur Mikrobiologie, Ernst Moritz Arndt Universitat Greifswald, F L Jahn Strasse 15, D 17487 Greifswald, Germany
Mol Microbiol 58:409-25. 2005..To detect proteins that are particularly sensitive to oxidative stress we exposed growing B. subtilis cells to diamide, hydrogen peroxide or to the superoxide generating agent paraquat...
- A novel thiol oxidation-based mechanism for adriamycin-induced cell injury in human macrophagesReto Asmis
Division of Cardiovascular Medicine and Graduate Center for Nutritional Sciences, University of Kentucky, USA
FASEB J 19:1866-8. 2005..Macrophages treated with either adriamycin or the thiol oxidant diamide showed elevated levels of glutathione disulfide and increased protein-S-glutathionylation prior to cell injury, ..
- Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cellsRita Loch Caruso
Toxicology Program, Department of Environmental Health, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109 2029, USA
Toxicol Sci 86:417-26. 2005..Furthermore, treatments that promoted accumulation of GSSG (50 microM diamide and 25 microM 1,3-bis(2-chloroethyl)-1-nitrosourea [BCNU]) inhibited Lucifer yellow dye transfer between ..
- S-glutathionylation in human platelets by a thiol-disulfide exchange-independent mechanismIsabella Dalle-Donne
Department of Biology, University of Milan, Via Celoria 26, I 20133 Milan, Italy
Free Radic Biol Med 38:1501-10. 2005..in vitro by exposure of human platelets to the thiol-specific oxidant azodicarboxylic acid-bis-dimethylamide (diamide)...
- Thioredoxin reductase is essential for thiol/disulfide redox control and oxidative stress survival of the anaerobe Bacteroides fragilisEdson R Rocha
Department of Microbiology and Immunology, East Carolina University Brody School of Medicine, 600 Moye Blvd, Greenville, NC 27834, USA
J Bacteriol 189:8015-23. 2007..Expression of the B. fragilis trxB gene was induced following treatment with diamide or H(2)O(2) or exposure to oxygen. This inducible trxB expression was OxyR independent...
- Regulation of the catalytic activity and structure of human thioredoxin 1 via oxidation and S-nitrosylation of cysteine residuesSeyed Isaac Hashemy
Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Biol Chem 283:21890-8. 2008..Human Trx1 has also three structural Cys residues in positions 62, 69, and 73 that upon diamide oxidation induce a second Cys(62)-Cys(69) disulfide as well as dimers and multimers...
- An altered oxidant defense system in red blood cells affects their ability to release nitric oxide-stimulating ATPJamie Carroll
Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI 48202, USA
Mol Biosyst 2:305-11. 2006..These data suggest that the antioxidant status of erythrocytes is a critical determinant in the ability of these cells to release ATP, a known nitric oxide stimulus...
- Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damageThomas R Hurd
Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom
J Biol Chem 283:24801-15. 2008..In mitochondria incubated with the thiol oxidant diamide, complex I is only glutathionylated on the 75-kDa subunit...
- Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stressChinavenmeni S Velu
Anticancer Resistance Research Group, Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
Biochemistry 46:7765-80. 2007....
- Glutathione might exert an important function in caerulein-stimulated amylase release in isolated rat pancreatic aciniHonggang Yu
Division of Gastroenterology, Hepatology, and Infectious Diseases, Department of Medicine, Heinrich Heine University of Duesseldorf, Duesseldorf, Germany
Pancreas 24:53-62. 2002..The effect of different modes of thiol depletion on pancreatic exocrine secretory function and potential mechanisms of interference with the secretory process in pancreatic acinar cells were investigated...
- A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growthE G Muller
Department of Biochemistry, University of Washington, Seattle 98195 7350, USA
Mol Biol Cell 7:1805-13. 1996..In addition, the glr1 delta mutant shows increased sensitivity to the thiol oxidant diamide. The sensitivity to diamide was suppressed by deletion of the TRX2 gene...
- Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiaeS T Coleman
Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
J Biol Chem 276:244-50. 2001..bearing the glutamate decarboxylase gene (GAD1) increases resistance to two different oxidants, H(2)O(2) and diamide, in cells that contain an intact glutamate catabolic pathway. Structural similarity of the S...
- Regulation of yAP-1 nuclear localization in response to oxidative stressS Kuge
Institute of Medical Science, University of Tokyo, Minato ku, Japan
EMBO J 16:1710-20. 1997..We suggest therefore, that these cysteine residues are important in sensing the redox state of the cell and hence regulating yAP-1 activity...
- S-cysteinylation is a general mechanism for thiol protection of Bacillus subtilis proteins after oxidative stressFalko Hochgräfe
Institute for Microbiology, Ernst Moritz Arndt University Greifswald, D 17487 Greifswald, Germany
J Biol Chem 282:25981-5. 2007..having redox-sensitive thiols are modified by cysteine in response to treatment with the thiol-specific oxidant diamide. By means of multidimensional shotgun proteomics, the sites of S-cysteinylation for six proteins could be ..
- Different metabolizing ability of thiol reactants in human and rat blood: biochemical and pharmacological implicationsR Rossi
Department of Neuroscience, Pharmacology Unit, Via A. Moro 4, University of Siena, Italy
J Biol Chem 276:7004-10. 2001..protein mixed disulfides were produced in rat but not in human erythrocytes by treatment with hydroperoxides or diamide. The disappearance of all forms of glutathione (reduced, disulfide, protein mixed disulfide) was induced by ..
- GSH depletion, K-Cl cotransport, and regulatory volume decrease in high-K/high-GSH dog red blood cellsH Fujise
Laboratory of Pathobiochemistry, School of Veterinary Medicine, Azabu University, Fuchinobe, Sagamihara, Kanagawa 229, Japan
Am J Physiol Cell Physiol 281:C2003-9. 2001..chemical reactions [nitrite (NO(2))-mediated oxidation, diazene dicarboxylic acid bis-N,N-dimethylamide (diamide)-induced dithiol formation, and glutathione S-transferase (GST)-catalyzed conjugation of GSH with 1-chloro-2,4-..
- Induction of mild intracellular redox imbalance inhibits proliferation of CaCo-2 cellsT Noda
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932, USA
FASEB J 15:2131-9. 2001..Low concentrations of diamide plus 1,3-bis(2 chloroethyl)-1-nitrosourea (BCNU) increased intracellular GSSG and decreased GSH and the GSH:GSSG ..
- Responses of thiols to an oxidant challenge: differences between blood and tissues in the ratF Giannerini
Department of Neuroscience, Pharmacology Unit, University of Siena, Via A. Moro 4, 53100, Siena, Italy
Chem Biol Interact 134:73-85. 2001Treatment of rats with diamide (100 mg/kg i.p.) altered the thiol components of the blood to a very different extent than in tissues (liver, kidney, lung, spleen, heart and testis)...
- Resolution, detection, and characterization of redox conformers of human HSF1D J Manalo
Graduate Program in Cell and Developmental Biology and Department of Cell Biology and Neuroscience, Rutgers State University, Piscataway, New Jersey 08854-8082, USA
J Biol Chem 276:23554-61. 2001..We showed that diamide, a reagent that promotes disulfide bond formation, caused a loss of immunorecognition of the monomeric hHSF1 ..
- Modulation of ICl(Ca) in vascular smooth muscle cells by oxidizing and cysteine-reactive reagentsIain A Greenwood
Department of Pharmacology and Clinical Pharmacology, Cardiovascular Research Group, St Georges Hospital Medical School, London, UK
Pflugers Arch 443:473-82. 2002..through voltage-dependent Ca2+ channels was markedly and irreversibly enhanced by the non-specific oxidant, diamide (10-200 microM). Diamide also prolonged the decay of both currents...
- Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infectionPietro Ghezzi
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
Mol Immunol 38:773-80. 2002..Treating the cells with the oxidant diamide induces thiolation of a series of proteins that can be detected by 2D electrophoresis when 35S-cysteine is used ..
- Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species productionErin K Pias
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
FASEB J 16:781-90. 2002..Cells grown in standard DMEM containing 25 mM glucose were treated with diamide, a thiol oxidant, at a concentration that did not generate ROS...
- Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expressionRiccardo Manganelli
TB Center, The Public Health Research Institute at the International Center for Public Health, Newark, NJ 07103 3506, USA
Mol Microbiol 45:365-74. 2002..and its involvement in the global regulation of the response to heat shock and the thiol-specific oxidizing agent diamide. We identified 48 genes whose expression increased after exposure of M...
- [The role of thiol oxidants in inhibition of pancreatic exocrine secretory function and glutathione]Honggang Yu
Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China
Zhonghua Nei Ke Za Zhi 41:306-9. 2002..Glutathione depletion has been described in all form of acute pancreatitis. This study evaluated the effect of glutathione depletion on pancreatic exocrine secretory function and explored the potential mechanisms...
- Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiolsX Liu
Department of Pharmacology, University of Glasgow
Br J Pharmacol 111:1287-95. 1994..2. Treatment of BRP muscle with either of two sulphydryl inactivating agents, diamide (1 mM) and N-ethylmaleimide (0...
- Evidence that protein disulfide isomerase (PDI) is involved in DNA-nuclear matrix anchoringRobert P VanderWaal
Washington University School of Medicine, Division of Radiation and Cancer Biology, Department of Radiation Oncology, St Louis, Missouri 63108, USA
J Cell Biochem 85:689-702. 2002..Both effects on DNA supercoiling ability were reversed by diamide suggesting that they are dependent on the oxidation state of the protein thiols...
- Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosisDerick Han
University of Southern California Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089 9121, USA
Free Radic Biol Med 41:627-39. 2006..Redox changes seem to be important in sensitizing primary hepatocytes, because diamide, a thiol-oxidizing agent, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), an inhibitor of GSSG reductase, also ..
- Heterogeneity of the neuropeptide Y (NPY) contractile and relaxing receptors in horse penile small arteriesDolores Prieto
Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
Br J Pharmacol 143:976-86. 2004..NPY(3-36), the compound 1229U91 (Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic(2,4')diamide) and eventually NPY(13-36) relaxed penile small arteries...
- The relaxant activity of 4,7-dimethyl-1,2,5-oxadiazolo[3,4-d]-pyridazine 1,5,6-trioxide in the mouse corpus cavernosumCemil Gocmen
Department of Pharmacology, Cukurova University Medical School, Adana, Turkey
J Pharmacol Exp Ther 316:753-61. 2006..Thiol alkylation agent N-ethylmaleimide significantly enhanced FPTO-induced relaxation, and thiol-modifying agent diamide inhibited relaxation to FPTO...
- Formation of disulfide-linked complexes between the three minor envelope glycoproteins (GP2b, GP3, and GP4) of equine arteritis virusRoeland Wieringa
Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
J Virol 77:6216-26. 2003..Furthermore, the conversion was almost instantaneous in the presence of the thiol oxidant diamide. In contrast, the sulfhydryl-modifying agent N-ethylmaleimide inhibited the formation of disulfide-bonded GP(2b)/..
- The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interactionMagnus M Berglund
Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN 46285, USA
J Pharmacol Exp Ther 306:147-56. 2003..at the Y4 receptor, the Y4 agonist 1229U91 [(Ile,Glu,Pro,Dpr,Tyr,Arg, Leu,Arg,Try-NH2)-2-cyclic(2,4'),(2',4)-diamide] was unable to provoke the same maximal response as human PP, suggesting that 1229U91 is a partial agonist...
- Oxidative stress inactivates cobalamin-independent methionine synthase (MetE) in Escherichia coliElise R Hondorp
Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA
PLoS Biol 2:e336. 2004..Moreover, MetE is completely oxidized in wild-type E. coli treated with the thiol-oxidizing agent diamide; reduced enzyme reappears just prior to the cells resuming normal growth. We argue that for E...
- Reactions of aromatic N-heterocycles with d0fn-metal alkyl complexes supported by chelating diamide ligandsPaula L Diaconescu
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
Acc Chem Res 43:1352-63. 2010..The comparison between yttrium and lutetium benzyl complexes supported by ferrocene- or pyridine-diamide ligands indicated that similar reactions occurred for specific substrates (1-methylimidazole, 2-picoline, and ..
- Novel application of S-nitrosoglutathione-Sepharose to identify proteins that are potential targets for S-nitrosoglutathione-induced mixed-disulphide formationP Klatt
Department of Estructura y Función de Proteínas, Centro de Investigaciones Biologicas, Instituto Reina Sofía de Investigaciones Nefrológicas, Consejo Superior de Investigaciones Cientificas, Velazquez 144, E 28006 Madrid, Spain
Biochem J 349:567-78. 2000..to this matrix correlated well with the susceptibility of the investigated proteins to undergo GSNO- but not diamide-induced mixed-disulphide formation in vitro...
- Redox pacing of proteome turnover: influences of glutathione and ketonemiaThomas D Lockwood
Department of Pharmacology, School of Medicine, Wright State University, Cox Bldg, 3525 Southern Blvd, Kettering, OH 45429, USA
Arch Biochem Biophys 417:183-93. 2003..More than 75% of myocardial protein degradation was inhibited and defined by infusion of diamide (100 microM) under constant physiologic concentrations of complete amino acids...
- Reverse genetic analysis of the glutathione metabolic pathway suggests a novel role of PHGPX and URE2 genes in aluminum resistance in Saccharomyces cerevisiaeU Basu
Department of Biological Sciences, University of Alberta, T6G 2E9, Edmonton, Alberta, Canada
Mol Genet Genomics 271:627-37. 2004..phgpx3Delta and phgpx1Delta/2Delta/3Delta mutants were sensitive to oxidative stress (exposure to H(2)O(2) or diamide). Lipid peroxidation was also increased in the phgpx1Delta/2Delta/3Delta mutant compared to the parental strain...
- Induction of heme-oxygenase 1 inhibits endothelial cell activation by endotoxin and oxidant stressEileen M Bulger
Department of Surgery, University of Washington, Seattle, WA, USA
Surgery 134:146-52. 2003..We hypothesized that the induction of HO-1 protein would attenuate the proinflammatory response of endothelial cells to lipopolysaccharide and oxidant stress...
- Ischemia-elicited oxidative modulation of Ca2+/calmodulin-dependent protein kinase IIPavan K Shetty
Developmental Neurobiology Program, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 283:5389-401. 2008..Treatment of mouse brain synaptosomes with H2O2, diamide, and sodium nitroprusside caused aggregation of CaMKII through formation of disulfide and non-disulfide linkages, ..
- Glucose regulation of hydroperoxide metabolism in rat intestinal cells. Stimulation of reduced nicotinamide adenine dinucleotide phosphate supplyT Y Aw
Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport 71130
J Clin Invest 94:2426-34. 1994..The NADPH supply rate was quantified by controlled infusions of diamide, a thiol oxidant. At diamide infusion of 0...
- Protein thiol modifications of human red blood cells treated with t-butyl hydroperoxideC K Lii
Department of Nutrition, Chung Shan Medical College, Taichung, Taiwan, ROC
Biochim Biophys Acta 1336:147-56. 1997..As red blood samples were treated with diamide or GSSG, in addition to the mixed disulfides observed in t-BH-treated cells, additional hemoglobin-GSH mixed ..
- The mitochondrial carnitine carrier: characterization of SH-groups relevant for its transport functionC Indiveri
Department of Pharmaco Biology, University of Bari, Italy
Biochim Biophys Acta 1140:53-8. 1992..of consecutive additions of various reagents including N-ethylmaleimide, mercurials, Cu(2+)-phenanthroline and diamide on the transport function revealed the presence of at least two different classes of SH-groups...
- The bZip transcription factor Cgap1p is involved in multidrug resistance and required for activation of multidrug transporter gene CgFLR1 in Candida glabrataKuang Hua Chen
Clinical Mycology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
Gene 386:63-72. 2007..suppressed the drug sensitivity of two Yap1p-regulated transporter mutants, Deltaatr1 and Deltaflr1, to diamide, 4-NQO, and cadmium...
- Curative activity of insecticides on Rhagoletis pomonella (Diptera: Tephritidae) in applesJohn C Wise
Department of Entomology, Michigan State University, East Lansing, MI 48824, USA
J Econ Entomol 102:1884-90. 2009..The pyrethroid esfenvalerate, oxadiazine indoxacarb, anthranilic diamide chlorantraniliprole, and spinosyns spinosad and spinetoram did not show activity on apple maggot eggs and larvae ..
- Molecular recognition of synthetic siderophore analogues: a study with receptor-deficient and fhu(A-B) deletion mutants of Escherichia coliM Gaspar
Centro de Quimica Estrutural, Instituto Superior Tecnico, Lisboa, Portugal
Biometals 12:209-18. 1999..In comparison with other polyamino-polyhydroxamate ligands studied, this dihydroxamate ligand has an extra diamide backbone that could be important for the interaction with the receptors or with FhuD...
- Poly(ADP-ribose) glycohydrolase activity mediates post-traumatic inflammatory reaction after experimental spinal cord traumaSalvatore Cuzzocrea
Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
J Pharmacol Exp Ther 319:127-38. 2006..gene in mice or the pharmacological inhibition of PARG with GPI 16552 [N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide] (40 mg/kg i.p...
- Wild plants, Andropogon virginicus L. and Miscanthus sinensis Anders, are tolerant to multiple stresses including aluminum, heavy metals and oxidative stressesBunichi Ezaki
Research Institute for Bioresources, Okayama University, 2 20 1, Chuo, Kurashiki, Okayama 710 0046, Japan
Plant Cell Rep 27:951-61. 2008..The two high Al tolerant plants, Andropogon and/or Miscanthus, showed tolerance to Cr, Zn, diamide or hydrogen peroxide, suggesting common tolerance mechanisms among the tested stresses...
- 99mTc renal tubular function agents: current statusD Eshima
Emory University School of Medicine, Atlanta, GA
Semin Nucl Med 20:28-40. 1990..The search for a suitable 99mTc renal tubular function agent has focused on the diamide dithiolate (N2S2), the paraaminohippuric iminodiacetic acid (PAHIDA), and the triamide mercaptide (N3S) donor ..
- The effect of oxidant and the non-oxidant alteration of cellular thiol concentration on the formation of protein mixed-disulfides in HEK 293 cellsJasen Lee Gilge
Department of Chemistry, John Carroll University, University Height, Ohio, United States of America
PLoS ONE 3:e4015. 2008..proteins were demonstrated in human embryonic kidney 293 cells treated with two different oxidative reagents: diamide and hydrogen peroxide. Diamide is a chemical oxidizing agent whereas hydrogen peroxide is a physiological oxidant...
- Design of novel bicyclic analogues derived from a potent oxytocin antagonistGeorge Flouret
Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611, USA
J Pept Sci 12:412-9. 2006..The [desamido(9)] PA-ethylenediamine monoamide, 6, and the dimer ([desamido(9)]-PA)(2) ethylenediamine diamide, 7, had lower potency in the uterotonic assay than PA...
- Insect ryanodine receptors: molecular targets for novel pest control chemicalsDavid B Sattelle
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Invert Neurosci 8:107-19. 2008..The phthalic acid diamide class has yielded flubendiamide, the first synthetic ryanodine receptor insecticide to be commercialized...
- Enantiomeric separation using temperature-responsive chiral polymers composed of L-valine diamide derivatives in aqueous liquid chromatographyKaori Kurata
Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachiouji, Tokyo 192 0392, Japan
J Chromatogr A 1012:47-56. 2003..could not provide enantioselectivity for the amino acid derivatives in aqueous media, although the chiral valine diamide moieties were effective for enantiomer separation in non-aqueous media...
- Mitochondrial Iron-Sulfur cluster mechanisms and therapy in Friedreich's ataxiaGino A Cortopassi; Fiscal Year: 2013..In Aim 3 we will test the activity of the 9 most diamide-protective drugs for their ability to rescue frataxin expression, iron-sulfur cluster defects, and auranofin ..
- TOXICITY OF CARDIAC HYPOXIA AND REOXYGENATIONJAMES KEHRER; Fiscal Year: 1991..lysis at reoxygenation will be further studied by assessing the effect of 2 additional inhibitors of this enzyme, diamide and vanadium, on cardiac LDH release...
- Biomedical Polymers With Heparin-Binding End GroupsRobert Ward; Fiscal Year: 2004..A novel diamine-diamide-alcohol (PIME-SME) synthesis procedure will be optimized for high yield and low cost...
- MECHANISM OF SELENIUM INDUCED CATARACTThomas Shearer; Fiscal Year: 2002..proteolytic- insolubilization mechanism occurs in most other models of rodent cataracts (galactose, xylose, H2O2, diamide, A23187, BSO), regardless of the initial insult allowing influx of calcium, and even in normal maturation of ..
- CHELATE CONJUGATED RADIOLABELED MONOCLONAL ANTIBODIESRichard Reba; Fiscal Year: 1990..The diamide dithiol derivatives are labeled with Tc-99m before and after the conjugation to antibody...
- REDOX REGULATION OF TRANSCRIPTION FACTOR FUNCTIONW Moye Rowley; Fiscal Year: 2003..Truncated mutant forms of yAP-1 are hyper-resistant to diamide stress but hypersensitive to H2O2...
- Polyurethane Biomaterials with Heparin Binding SitesRobert Ward; Fiscal Year: 2002..A diamine-diamide-diol (PIME), which has an established ability to bind heparin, will replace some of the normal diol 'chain ..
- OXIDANT REGULATION OF RENAL CELL GROWTH AND VIABILITYCHERYL SCHEID; Fiscal Year: 1999..The cells will be treated with hydrogen peroxide (a representative oxidant) or diamide (to deplete sulfhydryl groups) and then examined by northern blotting, western blotting and if necessary RT-PCR ..
- REGULATION AND FUNCTION OF LUNG SPECIFIC FREAC GENESYe Shih Ho; Fiscal Year: 2002..abstract_text> ..
- Structure/Function of Peroxisomes in NeuroinflammationInderjit Singh; Fiscal Year: 2008..unreadable] [unreadable]..
- Imbalancing DNA BER to enhance Ovarian Tumor SensitivityMark Kelley; Fiscal Year: 2008..abstract_text> ..
- SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTSBARRY SNIDER; Fiscal Year: 2009..In the course of these studies new methods will be developed that are of general utility for preparing drugs more economically. ..
- Nitric oxide and mitochondrial biogenesis in sepsisClaude A Piantadosi; Fiscal Year: 2010..abstract_text> ..
- Glutaredoxin, Macrophage Death and AtherosclerosisRETO H R ASMIS; Fiscal Year: 2010..The proposed studies will test this hypothesis and examine possible molecular mechanisms of Grx-mediated protection of macrophages from mitochondrial dysfunction and cell death. ..
- Antioxidant Interaction of Selenium and Vitamins C & EJames May; Fiscal Year: 2008..Using this approach, it will be possible to relate the crucial, mitochondrial functions of selenium and vitamins C and E to the antioxidant defenses of the whole animal. ..
- Therapeutic/Mechanistic Role of Ape1 in Germ Cell TumorsMark Kelley; Fiscal Year: 2007..If any mutants are shown to sensitize the GCT cell lines to chemo-/IR agents, as expected, this will set the stage for future gene therapy approaches to sensitize GCT's to therapy. ..
- COAT-PlateletsGeorge Dale; Fiscal Year: 2005..abstract_text> ..
- MITOCHONDRIAL PROTEIN IMPORT IN AFRICAN TRYPANOSOMESMinu Chaudhuri; Fiscal Year: 2002..Understanding of this developmental process will elucidate one of the major aspects of trypanosomal parasitism. This in turn will help us to design rational trypanocidal chemotherapeutic strategies. ..
- Antioxidant Functions of Lipoic AcidJames May; Fiscal Year: 2004..Despite the widespread use of lipoic acid, these studies are necessary to establish the biological basis and rationale for the clinical use of the agent. ..
- POSTDOCTORAL HEMATOLOGY RESEARCH TRAININGGeorge Dale; Fiscal Year: 2003..Francis Fdt. (OUHSC). All members of the faculty work closely together under Specialized Center of Research (SCOR) and Program Project (PP)...
- Antioxidant vitamins in models of Alzheimer's DiseaseJames May; Fiscal Year: 2008..If antioxidant vitamins ameliorate toxicity in cell and animal models of Alzheimer's disease, then oxidant stress is involved in disease progression, and antioxidant vitamin supplements may be beneficial. ..
- Lung Injury Protection by Coagulation BlockadeCLAUDE PIANTADOSI; Fiscal Year: 2008..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
- Mechanism of Actions of Multitasking of Statins in ADInderjit Singh; Fiscal Year: 2006..abstract_text> ..
- OXIDATIVE DNA DAMAGE AND REPAIR IN CNS CELLSMark Kelley; Fiscal Year: 2003..abstract_text> ..
- DEVELOPMENT OF MORE EFFICIENT CHIRAL STATIONARY PHASESTingyu Li; Fiscal Year: 2002..The chemistry associated with the characterization of chiral stationary phases on silica gel will also be studied. ..