anhydrides

Summary

Summary: Chemical compounds derived from acids by the elimination of a molecule of water.

Top Publications

  1. ncbi Biophysical properties of phenyl succinic acid derivatised hyaluronic acid
    Maria Teresa Neves-Petersen
    NanoBiotechnology Group, Department of Physics and Nanotechnology, Aalborg University, Skjernvej 4A, Aalborg, Denmark
    J Fluoresc 20:483-92. 2010
  2. ncbi RNA structure analysis at single nucleotide resolution by selective 2'-hydroxyl acylation and primer extension (SHAPE)
    Edward J Merino
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
    J Am Chem Soc 127:4223-31. 2005
  3. ncbi Oxyanion hole stabilization by C-H···O interaction in a transition state--a three-point interaction model for Cinchona alkaloid-catalyzed asymmetric methanolysis of meso-cyclic anhydrides
    Hui Yang
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
    J Am Chem Soc 135:5808-18. 2013
  4. ncbi Hyperpolarized (13) C-labelled anhydrides as DNP precursors of metabolic MRI agents
    Sonia Colombo Serra
    Centro Ricerche Bracco, Bracco Imaging SpA, Via Ribes 5, 10010, Colleretto Giacosa, TO, Italy
    Contrast Media Mol Imaging 7:469-77. 2012
  5. ncbi Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide
    Luke J Leman
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:20-1. 2006
  6. ncbi Mechanical behaviour of pine wood chemically modified with a homologous series of linear chain carboxylic acid anhydrides
    Antonios N Papadopoulos
    Technological Education Institute of Kavala, Branch of Drama, Department of Forestry and Management of Natural Environment, Laboratory of Wood Science and Technology, TK 66100, Drama, Greece
    Bioresour Technol 101:6147-50. 2010
  7. ncbi Use of mixed anhydrides for the determination of terfenadine in dosage forms and spiked human plasma
    A A Al-Majed
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    J Pharm Biomed Anal 23:281-9. 2000
  8. ncbi Identifying airway sensitizers: cytokine mRNA profiles induced by various anhydrides
    L M Plitnick
    University of North Carolina, Curriculum in Toxicology, Chapel Hill, NC 27599, USA
    Toxicology 193:191-201. 2003
  9. ncbi Occupational contact urticaria caused by cyclic acid anhydrides
    Eva Helaskoski
    Department of Occupational Medicine, Finnish Institute of Ocuupational Health, Helsinki, Finland
    Contact Dermatitis 60:214-21. 2009
  10. ncbi Alternating copolymerization of epoxides and cyclic anhydrides: an improved route to aliphatic polyesters
    Ryan C Jeske
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853 1301, USA
    J Am Chem Soc 129:11330-1. 2007

Detail Information

Publications235 found, 100 shown here

  1. ncbi Biophysical properties of phenyl succinic acid derivatised hyaluronic acid
    Maria Teresa Neves-Petersen
    NanoBiotechnology Group, Department of Physics and Nanotechnology, Aalborg University, Skjernvej 4A, Aalborg, Denmark
    J Fluoresc 20:483-92. 2010
    Modification of hyaluronic acid (HA) with aryl succinic anhydrides results in new biomedical properties of HA as compared to non-modified HA, such as more efficient skin penetration, stronger binding to the skin, and the ability to blend ..
  2. ncbi RNA structure analysis at single nucleotide resolution by selective 2'-hydroxyl acylation and primer extension (SHAPE)
    Edward J Merino
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
    J Am Chem Soc 127:4223-31. 2005
    ..Modest extensions of the SHAPE approach will allow RNA structure to be monitored comprehensively and at single nucleotide resolution for RNAs of arbitrary sequence and structural complexity and under diverse solution environments...
  3. ncbi Oxyanion hole stabilization by C-H···O interaction in a transition state--a three-point interaction model for Cinchona alkaloid-catalyzed asymmetric methanolysis of meso-cyclic anhydrides
    Hui Yang
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
    J Am Chem Soc 135:5808-18. 2013
    ..Through DFT calculations, we show that asymmetric methanolysis of meso-cyclic anhydrides (AMMA) catalyzed by a class of cinchona alkaloid catalysts involves an oxyanion hole consisting of purely C-H ..
  4. ncbi Hyperpolarized (13) C-labelled anhydrides as DNP precursors of metabolic MRI agents
    Sonia Colombo Serra
    Centro Ricerche Bracco, Bracco Imaging SpA, Via Ribes 5, 10010, Colleretto Giacosa, TO, Italy
    Contrast Media Mol Imaging 7:469-77. 2012
    ..In particular, it has been shown that, by using symmetric anhydrides as chemical precursors for short-chain fatty acids, no glass-forming additives are needed in the DNP ..
  5. ncbi Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide
    Luke J Leman
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:20-1. 2006
    ..We report that high-energy aminoacyl-phosphate anhydrides and aminoacyl adenylates are generated in solutions containing amino acids, COS, and the corresponding phosphate ..
  6. ncbi Mechanical behaviour of pine wood chemically modified with a homologous series of linear chain carboxylic acid anhydrides
    Antonios N Papadopoulos
    Technological Education Institute of Kavala, Branch of Drama, Department of Forestry and Management of Natural Environment, Laboratory of Wood Science and Technology, TK 66100, Drama, Greece
    Bioresour Technol 101:6147-50. 2010
    ..of the effect of molecular size of the substituent group of softwood modified with linear chain carboxylic acid anhydrides, namely acetic, propionic, butyric, valeric, hexanoic, upon the compression strength has also been performed...
  7. ncbi Use of mixed anhydrides for the determination of terfenadine in dosage forms and spiked human plasma
    A A Al-Majed
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    J Pharm Biomed Anal 23:281-9. 2000
    Terfenadine reacts with mixed anhydrides (malonic and acetic anhydrides) producing a yellow-coloured product with intense fluorescence...
  8. ncbi Identifying airway sensitizers: cytokine mRNA profiles induced by various anhydrides
    L M Plitnick
    University of North Carolina, Curriculum in Toxicology, Chapel Hill, NC 27599, USA
    Toxicology 193:191-201. 2003
    ..Within the LMW chemicals, one of the major classes involved in these effects are the acid anhydrides. The immunological basis of respiratory hypersensitivity involves CD4+ cells...
  9. ncbi Occupational contact urticaria caused by cyclic acid anhydrides
    Eva Helaskoski
    Department of Occupational Medicine, Finnish Institute of Ocuupational Health, Helsinki, Finland
    Contact Dermatitis 60:214-21. 2009
    Cyclic acid anhydrides often cause allergic respiratory diseases, but contact urticaria because of these anhydrides has been considered rare.
  10. ncbi Alternating copolymerization of epoxides and cyclic anhydrides: an improved route to aliphatic polyesters
    Ryan C Jeske
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853 1301, USA
    J Am Chem Soc 129:11330-1. 2007
  11. ncbi One-step synthesis of complex nitrogen heterocycles from imines and alkyl-substituted maleic anhydrides
    Yuchen Tang
    Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
    Org Lett 11:3802-5. 2009
    Substituted maleic anhydrides react with imines to form polycyclic lactam products...
  12. ncbi Carboxyl BODIPY dyes from bicarboxylic anhydrides: one-pot preparation, spectral properties, photostability, and biolabeling
    Dongchuan Wang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhongshan Road, Dalian 116012, PR China
    J Org Chem 74:7675-83. 2009
    ..and functionalized with a free carboxyl group have been conveniently synthesized from pyrroles and dicarboxylic anhydrides in one-pot reactions...
  13. ncbi Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    J Appl Toxicol 22:317-25. 2002
    There is some debate regarding whether occupational asthma induced by respiratory sensitizing acid anhydrides is mediated by the induction of T helper (Th) 2-type responses and the production of IgE, with failure to detect specific IgE ..
  14. ncbi Characterization in mice of the immunological properties of five allergenic acid anhydrides
    R J Dearman
    Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK
    J Appl Toxicol 20:221-30. 2000
    Occupational exposure to certain acid anhydrides, including trimellitic anhydride (TMA), maleic anhydride (MA), phthalic anhydride (PA), hexahydrophthalic anhydride (HHPA) and methyltetrahydrophthalic anhydride (MTHPA), has been ..
  15. ncbi Characterization and in vitro degradation of poly(octadecanoic anhydride)
    An Jie Dong
    Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    J Mater Sci Mater Med 19:39-46. 2008
    ..98), only 1.64% weight loss for 20 days, and it completely degrades after 18 days in basic buffer (pH 7.4). Comparing with poly(sebacic anhydride) (PSA), POA has the higher crystallization degree, and the slower hydrolytic rate...
  16. ncbi Triflic anhydride mediated cyclization of 5-hydroxy-substituted pyrrolidinones for the preparation of alpha-trifluoromethylsulfonamido furans
    Albert Padwa
    Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA
    J Org Chem 68:5139-46. 2003
    ..In certain cases, the sulfonamide furan was utilized as a cycloaddition substrate for the synthesis of indolines and related heterocyclic systems...
  17. ncbi Phosphine-free cross-coupling reaction of arylboronic acids with carboxylic anhydrides or acyl chlorides in aqueous media
    Bingwei Xin
    Department of Chemistry, Zhejiang University, Hangzhou 310027, P R China
    J Org Chem 71:5725-31. 2006
    ..The Pd(OAc)2-H2O-[bmim][PF6] catalytic system can be recovered and reused eight times with high efficiency for both carboxylic anhydride and acyl chloride...
  18. ncbi A stereoselective three-component reaction: KAl(SO4)2.12H2O, an efficient and reusable catalyst for the one-pot synthesis of cis-isoquinolonic acids
    Javad Azizian
    Department of Chemistry, Faculty of Science, Shahid Beheshti University, P O Box 19395 4716, Tehran, Iran
    J Org Chem 70:350-2. 2005
    ....
  19. ncbi Synthesis of Nepsilon-protected-L-lysine and gamma-benzyl-L-glutamate N-carboxyanhydrides (NCA) by carbamoylation and nitrosation
    W Vayaboury
    Universite de Montpellier II, UMR 5073 CNRS, Montpellier, France
    Amino Acids 27:161-7. 2004
    ..It also showed that this new process of NCA synthesis could be applied to the synthesis of polypeptides and more generally to the protein chemistry...
  20. ncbi Gamma-irradiation stability of saturated and unsaturated aliphatic polyanhydrides--ricinoleic acid based polymers
    D Teomim
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Biomacromolecules 2:1015-22. 2001
    ..This anhydride bond may be cleaved to form two radicals that further react with aliphatic anhydride bonds along the polymer chain to form inter- and/or intracyclization products...
  21. ncbi Rhodium-catalyzed enantioselective desymmetrization of meso-3,5-dimethyl glutaric anhydride: a general strategy to syn-deoxypolypropionate synthons
    Matthew J Cook
    Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA
    J Am Chem Soc 129:9302-3. 2007
  22. ncbi The effect of storage temperatures on the in vitro properties of a polyanhydride implant containing gentamicin
    Y Tian
    Alcon Laboratories, R2 45, 6201 South Freeway, Fort Worth, Texas 76134 2099, USA
    Drug Dev Ind Pharm 28:897-903. 2002
    ....
  23. ncbi Determination of dendrigraft poly-L-lysine diffusion coefficients by taylor dispersion analysis
    Herve Cottet
    Institut des Biomolecules Max Mousseron IBMM, UMR 5247 CNRS Universite de Montpellier 1 Universite de Montpellier 2, place Eugène Bataillon CC 017, 34095, Montpellier Cedex 5, France
    Biomacromolecules 8:3235-43. 2007
    ....
  24. ncbi An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: a powerful and convenient mixed anhydride method promoted by basic catalysts
    Isamu Shiina
    Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku ku, Tokyo 162 8601, Japan
    J Org Chem 69:1822-30. 2004
    ..The efficiency of the cyclizations is compared to those of other reported lactonizations...
  25. ncbi Characterization and in vitro degradation of salicylate-derived poly(anhydride-ester microspheres)
    Brian A Yeagy
    Department of Pharmaceutics, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Microencapsul 23:643-53. 2006
    ..These results demonstrate that salicylate-based poly(anhydride-esters) with sufficiently high Tgs, can be processed into microspheres that release salicylate over a time period amenable for drug delivery applications...
  26. ncbi Hydrolytic degradation of ricinoleic-sebacic-ester-anhydride copolymers
    Michal Y Krasko
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel
    Biomacromolecules 6:1877-84. 2005
    ..It was established that during the hydrolysis under physiological conditions the degradation products have a composition and water absorption similar to those of the synthesized oligoesters...
  27. ncbi Synthesis of chitosan-based polymeric surfactants and their adsorption properties for heavy metals and fatty acids
    Moo Yeal Lee
    Department of International Development Engineering, Tokyo Institute of Technology, 2 12 1 Ookayama, Meguro ku, Tokyo 152 8552, Japan
    Int J Biol Macromol 36:152-8. 2005
    ..polymeric surfactants (CBPSs) were prepared by N-acylation of chitosans (chitosan 10 and 500) with several acid anhydrides such as hexanoic (C6), lauric (C12), and palmitic (C16) anhydrides...
  28. ncbi Evaluation of anhydride oligomers within polymer microsphere blends and their impact on bioadhesion and drug delivery in vitro
    C A Santos
    Spherics, Inc, Lincoln, RI 02865, USA
    Biomaterials 24:3571-83. 2003
    ....
  29. ncbi Nanometric dispersion of a Mg/Al layered double hydroxide into a chemically modified polycaprolactone
    Pasqualina Mangiacapra
    Dipartimento di Ingegneria Chimica e Alimentare, Universita di Salerno, Via Don Melillo 1, 84084 Fisciano SA, Italy
    Biomacromolecules 8:773-9. 2007
    ..This is an interesting method to obtain a direct intercalation of the modified polymer into the inorganic solid with a simple ionic exchange reaction...
  30. ncbi Pd-catalyzed stereoselective oxidation of methyl groups by inexpensive oxidants under mild conditions: a dual role for carboxylic anhydrides in catalytic C--H bond oxidation
    Ramesh Giri
    Department of Chemistry, Brandeis University, Waltham, MA 02454 9110, USA
    Angew Chem Int Ed Engl 44:7420-4. 2005
  31. ncbi Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst
    Asit K Chakraborti
    Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar 160 062, Punjab, India
    J Org Chem 71:5785-8. 2006
    ..The catalyst was found to be general for acylation with other anhydrides, such as propionic, isobutyric, pivalic, chloroacetic, and benzoic anhydrides...
  32. ncbi Kinetics of gelation and thermal sensitivity of N-isobutyryl chitosan hydrogels
    Leticia Félix
    Centro de Investigacion en Alimentacion y Desarrollo, Laboratory of Biopolymers, P O Box 1735, Hermosillo, Sonora, 83000 Mexico
    Biomacromolecules 6:2408-15. 2005
    N-Acylation of chitosan with carboxylic anhydrides in dilute acetic acid/methanol has been a well documented strategy to selectively modify chitosan...
  33. ncbi In vitro release of clomipramine HCl and buprenorphine HCl from poly adipic anhydride (PAA) and poly trimethylene carbonate (PTMC) blends
    Rassoul Dinarvand
    Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, P O Box 14155 6451, Tehran, Iran
    J Biomed Mater Res A 75:185-91. 2005
    ..However, the releases of buprenorphine HCl (5%) in the same devices were anomalous. For devices containing 50% and more PAA, surface erosion may play a significant role in the release of both molecules...
  34. ncbi Efficient preparation of proline N-carboxyanhydride using polymer-supported bases
    Oscar P Gulín
    Institute for Research in Biomedicine, Parc Científic de Barcelona IRB PCB, Universitat de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Org Lett 8:5385-8. 2006
    ..The polymer-supported amine can be recycled with a basic wash and filtration of the resin. The procedure facilitates the access to the efficient preparation of the polyproline polymer with potential therapeutic interest...
  35. ncbi Ligand-dependent catalytic cycle and role of styrene in nickel-catalyzed anhydride cross-coupling: evidence for turnover-limiting reductive elimination
    Jeffrey B Johnson
    Colorado State University, Fort Collins, CO 80523, USA
    J Am Chem Soc 129:2718-25. 2007
    Results from a mechanistic study on the Ni(COD)2-bipy-catalyzed alkylation of anhydrides are consistent with turnover-limiting reductive elimination at high Et2Zn concentrations...
  36. ncbi Mechanism for the degradation of erythromycin A and erythromycin A 2'-ethyl succinate in acidic aqueous solution
    Abdolreza Hassanzadeh
    Schools of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PL, UK
    J Phys Chem A 111:10098-104. 2007
    ....
  37. ncbi Linear conformation of poly(styrene-alt-maleic anhydride) capable of self-assembly: a result of chain stiffening by internal hydrogen bonds
    C Malardier-Jugroot
    Department of Chemistry, McGill University, Montreal, Canada, and Pulp and Paper Research Centre, McGill University, Montreal, Canada
    J Phys Chem B 109:7022-32. 2005
    ..This linearity does not depend on the chirality of the polymer. The linearity of the chain occurs only at intermediate pH and can explain the association among the chains observed by dynamic light scattering at pH 7...
  38. ncbi Design of an injectable system based on bioerodible polyanhydride microspheres for sustained drug delivery
    Matt J Kipper
    AP Pharma, Redwood City, CA 94063, USA
    Biomaterials 23:4405-12. 2002
    ..Additionally, the zero-order release can be extended from about a week to a month by including CPH:SA 50:50 microspheres...
  39. ncbi Hexamethyldisilazane-mediated controlled polymerization of alpha-amino acid N-carboxyanhydrides
    Hua Lu
    Department of Materials Science and Engineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Am Chem Soc 129:14114-5. 2007
  40. ncbi Crystalline and dynamic mechanical behaviors of synthesized poly(sebacic anhydride-co-ethylene glycol)
    Cheng Kuang Chan
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan
    Biomaterials 24:47-54. 2003
    ....
  41. ncbi Influence of acyl chain length on transfection mediated by acylated PEI nanoparticles
    Surendra Nimesh
    Dr B R Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India
    Int J Pharm 337:265-74. 2007
    ..The polymer was acylated using acid anhydrides of varying carbon chain length, followed by cross-linking with PEG-bis-P to form compact nanoparticles...
  42. ncbi The development of an injection-molding process for a polyanhydride implant containing gentamicin sulfate
    Jone Shin Deng
    Hospital Products Division, Abbott Laboratories 97D AP4, 100 Abbott Park Rd, Abbot Park, IL 60064, USA
    PDA J Pharm Sci Technol 56:65-77. 2002
    ..The injection-molding cycle was developed and evaluated in terms of cycle reproducibility. Implants were tested and shown to yield an oriented skin-core structure exhibiting a desirable in-vitro drug release profile...
  43. ncbi Catalytic enantioselective construction of all-carbon quaternary stereocenters: synthetic and mechanistic studies of the C-acylation of silyl ketene acetals
    Ara H Mermerian
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 127:5604-7. 2005
    With the aid of an appropriate chiral catalyst, acyclic silyl ketene acetals react with anhydrides to furnish 1,3-dicarbonyl compounds that bear all-carbon quaternary stereocenters in good ee and yield...
  44. ncbi Salicylic acid-derived poly(anhydride-esters) inhibit bone resorption and formation in vivo
    Robert D Harten
    Department of Orthopaedics, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    J Biomed Mater Res A 72:354-62. 2005
    ..These results indicate that locally released SA can significantly reduce both bone loss and bone formation in this animal model...
  45. ncbi [The synthesis of polyanhydrides and its application in biomedical field]
    Meili Yu
    Artificial Cell Engineering and Technology Research Center of Health Ministry, Third Center Hospital, Tianjin 300170
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 20:135-8. 2003
    ..Subsequently, the future researches and developments of polyanhydrides are prospected...
  46. ncbi Prolonging the action of protein and peptide drugs by a novel approach of reversible polyethylene glycol modification
    Haim Tsubery
    Departments of Biological Chemistry and Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 279:38118-24. 2004
    ....
  47. ncbi Derivatisation of 4-nonylphenol and bisphenol A with halogenated anhydrides
    A Stehmann
    Institut fuer Siedlungswasserwirtschaft, Aachen University, Templergraben 55, D 52056 Aachen, Germany
    Water Sci Technol 50:115-8. 2004
    ..The NMR-spectra contained the predicted resonance signals...
  48. ncbi From beta-N-tert-butyloxycarbonyl N-carboxyanhydrides to beta-aminoacid derivatives
    J Huck
    UMR 5810, CNRS LAPP Universités Montpellier I et II Place E, Bataillon 34095, Montpellier, Cedex, France
    J Pept Res 62:233-7. 2003
    ....
  49. ncbi Dakin-West synthesis of beta-aryl ketones
    Khanh Van Tran
    Department of Chemistry, Smith College, Northampton, Massachusetts 01063, USA
    J Org Chem 71:6640-3. 2006
    ..Hydrocinnamic acid, a compound previously reported to be unreactive under Dakin-West conditions, forms 4-phenyl-2-butanone when the reaction is catalyzed by 1-methylimidazole...
  50. ncbi Synthesis of a new seleninic acid anhydride and mechanistic studies into its glutathione peroxidase activity
    Sun Chol Yu
    Department of Pharmacy, Pyongyang Medical University, Ryonhwa dong, Central district Pyongyang DPR of Korea
    Chemistry 14:7066-71. 2008
    ..These data suggested that cycles A and B may constitute the major routes of GPx-like activity of 7, whereas cycle C may not significantly contribute to catalysis...
  51. ncbi 4-(Dimethylamino)pyridine N-oxide (DMAPO): an effective nucleophilic catalyst in the peptide coupling reaction with 2-methyl-6-nitrobenzoic anhydride
    Isamu Shiina
    Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku ku, Tokyo 162 8601, Japan
    Chem Asian J 3:454-61. 2008
    ....
  52. ncbi Branch-selective intermolecular hydroacylation: hydrogen-mediated coupling of anhydrides to styrenes and activated olefins
    Young Taek Hong
    Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station, A5300, 78712 1167, USA
    Angew Chem Int Ed Engl 45:6885-8. 2006
  53. ncbi One-pot synthesis of chemically modified vegetable oils
    Brajendra K Sharma
    Food and Industrial Oil Research Unit, USDA NCAUR ARS, 1815 N University Street, Peoria, Illinois 61604, USA
    J Agric Food Chem 56:3049-56. 2008
    ..synthesis of a novel class of chemically modified vegetable oils from epoxidized triacylglycerols and various anhydrides. In an anhydrous solvent, boron trifluoride etherate is used as catalyst to simultaneously open the oxirane ring ..
  54. ncbi Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis
    Mark C Sleeman
    Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom
    J Biol Chem 280:34956-65. 2005
    ..The structural work will aid in mutagenesis studies directed at altering the selectivity of CarB to provide intermediates for the production of clinically useful carbapenems...
  55. ncbi Development of environmentally friendly syntheses: use of enzymes and biomimetic systems for the direct carboxylation of organic substrates
    Michele Aresta
    Department of Chemistry and METEA Research Center, University of Bari, Italy
    J Biotechnol 90:113-28. 2002
    ..enzyme for the conversion of phenol into 4-OH benzoic acid; and (ii) the potential of biomimetic mixed anhydrides for the synthesis of compounds of industrial interest...
  56. ncbi Modeling studies of potato nucleoside triphosphate diphosphohydrolase NTPDase1: an insight into the catalytic mechanism
    Anna Kozakiewicz
    Department of Crystallochemistry and Biocrystallography, Institute of Chemistry, Torun, Poland
    Acta Biochim Pol 55:141-50. 2008
    ..The presence of two nucleophiles in the active site of apyrase explains the differences in the hydrolytic activity between apyrases and other enzymes belonging to the NTPDase family...
  57. ncbi Tools for microwave-assisted parallel syntheses and combinatorial chemistry
    Matthias Nüchter
    Institute of Technical Chemistry and Environmental Chemistry, Friedrich Schiller University Jena, Lessingstr 12, D 07743 Jena, Germany
    Mol Divers 7:253-64. 2003
    ..Emphasis is placed on similar reaction conditions in the individual vessels and the repeatability of results. Outcomes include esterifications and multi-center reactions exhibiting a great potential for combinatorial chemistry...
  58. ncbi Synthesis and characterization of novel poly(sebacic anhydride-co-Pluronic F68/F127) biopolymeric microspheres for the controlled release of nifedipine
    Namdev B Shelke
    Drug Delivery Division, Center of Excellence in Polymer Science, Karnatak University, Dharwad 580003, India
    Int J Pharm 345:51-8. 2007
    ....
  59. ncbi Supercritical fluid crystallization of griseofulvin: crystal habit modification with a selective growth inhibitor
    Daniel J Jarmer
    Department of Chemical and Biological Engineering, University of Colorado at Boulder, Center for Pharmaceutical Biotechnology, Boulder, Colorado, USA
    J Pharm Sci 94:2688-702. 2005
    ..Despite the change in crystal habit, griseofulvin crystals achieved 100% dissolution within 60 min in a simulated gastric fluid...
  60. ncbi Novel fluorescent copolyanhydrides as potential visible matrices for drug delivery
    H L Jiang
    Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China
    Biomaterials 23:2345-51. 2002
    ..The polymers were further fabricated to microsphere formulation, which can be clearly visualized by fluorescent microscopy...
  61. ncbi Side reactions in the H-phosphonate approach to oligonucleotide synthesis: a kinetic investigation on bisacylphosphite formation and 5'-O-acylation
    Susannah Sigurdsson
    Division of Organic and Bioorganic Chemistry, MBB, Scheele Laboratory, Karolinska Institutet, Stockholm, Sweden
    Nucleosides Nucleotides Nucleic Acids 22:1-12. 2003
    ..21 for 5'-O-pivaloylation). For both reactions considerably lower rates in the presence of sterically hindered pyridines suggest the existence of nucleophilic catalysis on pivaloyl chloride in reactions with non-hindered pyridines...
  62. ncbi Reaction of dimethoxycarbene-DMAD zwitterion with 1,2-diones and anhydrides: a novel synthesis of highly substituted dihydrofurans and spirodihydrofurans
    Vijay Nair
    Organic Chemistry Division, Regional Research Laboratory CSIR, Trivandrum, India
    J Org Chem 71:2313-9. 2006
    ..of dimethoxycarbene and DMAD adds efficiently to one of the carbonyl groups of 1,2-dicarbonyl compounds and anhydrides to generate dihydrofurans and spirodihydrofurans in good yields...
  63. ncbi Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction
    Jingqiang Wei
    Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Org Lett 9:4077-80. 2007
    A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity...
  64. ncbi The relationship between structures and in vitro properties of a polyanhydride implant containing gentamicin sulfate
    J S Deng
    Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064, USA
    Pharm Dev Technol 6:541-9. 2001
    ..The in vitro drug release of the cracking implants was markedly faster than that of the non-cracking implants due to the pronounced initial drug-burst effect as a result of crack formation in the implants...
  65. ncbi Anhydrides as acylating agents in the enzymatic resolution of an intermediate of (-)-Paroxetine
    Gonzalo de Gonzalo
    Departamento de Quimica Organica e Inorganica, Facultad de Quimica, Universidad de Oviedo, 33071 Oviedo, Spain
    J Org Chem 68:3333-6. 2003
    A new chemoenzymatic method for the preparation of an intermediate of (-)-Paroxetine is reported. Cyclic anhydrides are used as acylating agents in the lipase-catalyzed esterification of trans-4-(4'-fluorophenyl)-3-hydroxymethyl-N-..
  66. ncbi Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro
    P J Swart
    Department of Pharmaceutical Pharmacology and Clinical Pharmacy, University Centre for Pharmacy, Groningen, The Netherlands
    AIDS Res Hum Retroviruses 12:769-75. 1996
    ..By acylation of the amino function of the lysine residues in the proteins, using anhydrides of succinic acid or cis-aconitic acid, protein derivatives were obtained that all showed a strong antiviral ..
  67. ncbi Enantiomeric resolution of biomarkers in space analysis: Chemical derivatization and signal processing for gas chromatography-mass spectrometry analysis of chiral amino acids
    M C Pietrogrande
    Department of Chemistry, University of Ferrara, Via L Borsari, 46, I 44100 Ferrara, Italy
    J Chromatogr A 1217:1126-33. 2010
    ..to obtain the alkyl alkoxy carbonyl esters and a mixture of perfluorinated alcohols and anhydrides to form perfluoroacyl perfluoroalkyl esters...
  68. pmc Palladium-catalyzed coupling of ammonia with aryl chlorides, bromides, iodides, and sulfonates: a general method for the preparation of primary arylamines
    Giang D Vo
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Am Chem Soc 131:11049-61. 2009
    ..of a small library of these carbonyl compounds from aryl bromides and chlorides, ammonia, and acid chlorides or anhydrides. Mechanistic studies show that reactions conducted with the combination of Pd[P(o-tol)(3)](2) and CyPF-t-Bu as ..
  69. ncbi Occupational asthma due to low molecular weight agents
    F Di Stefano
    Department of Medicine and Science of Aging, Section of Allergy, Clinical Immunology and Occupational Medicine, University G D Annunzio, Chieti, Italy
    Int J Immunopathol Pharmacol 17:77-82. 2004
    ..Low molecular weight agents such as isocyanates, aldehydes, anhydrides, colophony, dyes, persulphate, amines, acrylates and metals are steadily increasing as causative agents of ..
  70. ncbi Sodium citrate supplementation in inborn argininosuccinate lyase deficiency: a study in a 5-year-old patient under total parenteral nutrition
    C Renner
    Universitätsklinik für Kinder und Jugendliche, Erlangen, Germany
    Eur J Pediatr 154:909-14. 1995
    ..8-41.7 mumol/l). Correspondingly serum concentrations of argininosuccinate and its anhydrides rose (270-458 mumol/l), positively correlated with the doses of sodium citrate...
  71. ncbi [Contact allergy to epoxy resins plastics based on materials collected by the Nofer Institute of Occupational Medicine]
    Marta Kiec-Swierczynska
    Przychodni Chorób Zawodowych Instytutu Medycyny, Łodzi
    Med Pr 54:145-8. 2003
    ..that allergy to resin, reactive diluents and plasticizers was on increase, whereas allergy to amines and acid anhydrides hardeners was on decrease...
  72. ncbi The risk of occupational rhinitis
    M Hytonen
    Finnish Institute of Occupational Health, Helsinki, Finland
    Int Arch Occup Environ Health 69:487-90. 1997
    ..Reports on the aetiology and risk of occupational rhinitis in different occupations are scarce...
  73. ncbi Carbonic anhydrase inhibitors: N-cyanosulfonamides, a new class of high affinity isozyme II and IV inhibitors
    C T Supuran
    Universita degli Studi, Laboratorio di Chimica Inorganica e Bioinorganica, Firenze, Italia
    J Enzyme Inhib 14:289-306. 1999
    ..has been prepared by reaction of alkyl-, arylalkyl- and arylsulfonyl halides or sulfonic acid anhydrides with cyanamide, or by reaction of cyanogen bromide with sulfamide/sulfamic acid...
  74. ncbi Spectrophotometric and titrimetric determination of nizatidine in capsules
    F A El-Yazbi
    Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, University of Alexandria, El Messalah, Alexandria 21521, Egypt
    J Pharm Biomed Anal 31:1027-34. 2003
    ..The second method depends on the condensation of mixed anhydrides of citric acid/acetic anhydride, with the tertiary amino group of the drug, where the developed color is ..
  75. ncbi Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors
    M Cushman
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Med Chem 43:3688-98. 2000
    ..The synthesis relied on the condensation of substituted Schiff bases with homophthalic anhydrides to produce cis-3-aryl-4-carboxyisoquinolones that were cyclized to indenoisoquinolines in the presence of ..
  76. ncbi Synthesis and solution properties of deferoxamine amides
    P M Ihnat
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, Nebraska 68198 6025, USA
    J Pharm Sci 89:1525-36. 2000
    ..amides were prepared by reacting the terminal primary amino group with fatty and aromatic acid chlorides or anhydrides. Octanol/water partition coefficients and equilibrium solubilities of these analogs in solvents, chosen to ..
  77. ncbi Argininosuccinic aciduria: clinical and biochemical findings in three children with the late onset form, with special emphasis on cerebrospinal fluid findings of amino acids and pyrimidines
    G P Gerrits
    Department of Pediatrics, University of Nijmegen, The Netherlands
    Neuropediatrics 24:15-8. 1993
    ..All patients showed elevated concentrations of argininosuccinic acid and its anhydrides in all body fluids, most pronounced in cerebrospinal fluid (CSF)...
  78. ncbi Protein stabilization via hydrophilization. Covalent modification of trypsin and alpha-chymotrypsin
    V V Mozhaev
    Chemistry Department, Moscow State University, USSR
    Eur J Biochem 173:147-54. 1988
    ..Alpha-chymotrypsin is covalently modified by treatment with anhydrides or chloroanhydrides of aromatic carboxylic acids...
  79. ncbi 3-Formylchromones IV. The rearrangement of 3-formylchromone enamines as a simple, facile route to novel pyrazolo[3,4-b]pyridines and the synthetic utility of the latter
    Margita Lácová
    Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, SK 842 15 Bratislava, Slovakia
    Molecules 10:809-21. 2005
    ..Acyloxy-derivatives 5 of compounds 4 were obtained by acylation with acid chlorides or acid anhydrides. Coumarins 6 substituted at the 3- and 4-positions were prepared from the pyrazolo[3,4-b]pyridines 4 by ..
  80. ncbi Design of bioinspired polymeric materials based on poly(D,L-lactic acid) modifications towards improving its cytocompatibility
    Xufeng Niu
    Research Center of Bioinspire Material Science and Engineering, Department of Bioengineering, Chongqing University, Chongqing 400030, People s Republic of China
    J Biomed Mater Res A 84:908-16. 2008
    ..neutralize the acid generated during DL-PLA degradation, aliphatic diamine was immobilized by the N-acylation of anhydrides with butanediamine...
  81. ncbi Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers
    Maarit Tarvainen
    Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Eur J Pharm Sci 19:363-71. 2003
    The aim of this study was to investigate the ability of n-alkenyl succinic anhydrides (n-ASAs) to improve the film-forming characteristics of a novel coating polymer, potato starch acetate degree of substitution 2.8 (SA)...
  82. ncbi Development of polymeric gene delivery carriers: PEGylated copolymers of L-lysine and L-phenylalanine
    Yi Rac Choi
    Department of Materials Science and Engineering, Hyperstructured Organic Materials Research Center HOMRC, Seoul National University, Seoul, South Korea
    J Drug Target 15:391-8. 2007
    ..acid)-based random copolymers were successfully synthesized by the ring opening polymerization of the N-carboxy anhydrides (NCA) of L-lysine and L-phenylalanine...
  83. ncbi Synthesis and reactions of some new substituted pyridine and pyrimidine derivatives as analgesic, anticonvulsant and antiparkinsonian agents
    Abd El Galil E Amr
    National Research Center, Cairo, Egypt
    Arch Pharm (Weinheim) 338:433-40. 2005
    ..Similarly, compound 2 was reacted with previous anhydrides to afford the corresponding imide 6 and bis-imide derivatives 7 and 8, respectively...
  84. ncbi From beta-lactams to alpha- and beta-amino acid derived peptides
    C Palomo
    Departamento de Quimica Organica, Facultad de Quimica, Universidad del Pais Vasco, San Sebastian, Spain
    Amino Acids 16:321-43. 1999
    ..lie, on one side, in the oxidative ring expansion of 3-hydroxy beta-lactams to N-carboxy alpha-amino acid anhydrides or Leuch's anhydrides and subsequent coupling with alpha-amino acid esters and, on the other side, in the ..
  85. ncbi Skin sensitization and possible groupings for 'read across' for rosin based substances
    H P A Illing
    PICS Ltd, Sherwood, Brimstage Road, Heswall, Wirral CH60 1XE, UK
    Regul Toxicol Pharmacol 54:234-41. 2009
    ..Esterification will deactivate acid anhydrides formed from reacting rosin with maleic anhydride or fumaric acid...
  86. ncbi Biodegradable synthetic polymers for tissue engineering
    P A Gunatillake
    CSIRO Molecular Science, Bag 10, Clayton South MDC, VIC 3169, Australia
    Eur Cell Mater 5:1-16; discussion 16. 2003
    ..work has focused on developing injectable polymer compositions based on poly (propylene fumarate) and poly (anhydrides) to meet these requirements in orthopaedic tissue engineering...
  87. ncbi Oxidation of cyclic dipeptides by photoinduced H-atom abstraction. A laser flash FT EPR and optical spectroscopy study
    Peter Tarabek
    Interdisciplinary Research Group Time Resolved Spectroscopy, Faculty of Chemistry and Mineralogy, University of Leipzig, Permoserstrasse 15, Leipzig, D 04318, Germany
    J Phys Chem A 111:4958-64. 2007
    ..employed in order to investigate the oxidation mechanism of cyclic dipeptides glycine, alanine, and sarcosine anhydrides initiated by SO4*- or 9,10-anthraquinone-2,6-disulfonate (2,6-AQDS) triplet in oxygen free aqueous solutions...
  88. ncbi Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats
    Josje H E Arts
    Toxicology Division, TNO Nutrition and Food Research, Zeist, The Netherlands
    Toxicol Appl Pharmacol 187:38-49. 2003
    Occupational exposure to low-molecular-weight (LMW) allergens such as acid anhydrides can result in occupational asthma, an allergic disease characterized by episodic airway obstruction, airways inflammation, and non specific airways ..
  89. ncbi An investigation of argininosuccinic acid anhydrides in argininosuccinic acid lyase deficiency by 1H-NMR spectroscopy
    S P Burns
    Medical Unit Cellular Mechanisms Research Group, London Hospital Medical College, Whitechapel, UK
    Clin Chim Acta 221:1-13. 1993
    ..3.2.1) deficiency (ASLD). Previous workers have reported the presence of anhydrides of ASA in the urine of patients with this disorder...
  90. ncbi Grafting of chitosan as a biopolymer onto wool fabric using anhydride bridge and its antibacterial property
    Marziyeh Ranjbar-Mohammadi
    Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran
    Colloids Surf B Biointerfaces 76:397-403. 2010
    ..In this paper, the surface modification of wool fabric using anhydrides to graft the chitosan was studied...
  91. ncbi Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors
    Fathy A Behery
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, United States
    Bioorg Med Chem 18:8066-75. 2010
    ..ester analogues 4-15 were prepared by direct esterification of natural tocotrienol isomers with various acid anhydrides or chlorides...
  92. ncbi Determination of some histamine H1-receptor antagonists in dosage forms
    Azza A Gazy
    Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt
    J Pharm Biomed Anal 30:859-67. 2002
    ..The last method involves the base-catalysed condensation of mixed anhydrides of organic acids (citric acid/acetic anhydride) where as the tertiary amino group in the above-cited drugs acts ..
  93. ncbi Carboxyketenes, methyleneketenes, vinylketenes, oxetanediones, ynols, and ylidic ketenes from Meldrum's acid derivatives
    Lisa George
    Chemistry Building, School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Org Biomol Chem 5:1437-41. 2007
    ..5-methylene-Meldrum's acid derivatives (1, 12 ) and their enols (2, 13) can undergo fragmentation to malonic anhydrides (4, 19 ), carboxyketenes (3, 16) and methyleneketene (5, 21 , 35 ), as well as cyclization to pyrrole-3-one and ..
  94. ncbi Cytotoxicity of 3,4-dihalogenated 2(5H)-furanones
    Eric Lattmann
    School of Life and Health Sciences, Biomedical Division, Aston University, Birmingham B4 7ET, UK
    J Pharm Pharmacol 56:1163-70. 2004
    ..In one synthetic step the carbamates 2a-c and the pseudoanhydrides 4a-e were prepared using isocyanates and acid anhydrides. A series of 5-alkoxylated 3,4-dichloro-2(5H)-furanones 5a-o have been synthesized with a wide range of ..
  95. pmc Validated stability-indicating spectrofluorimetric methods for the determination of ebastine in pharmaceutical preparations
    Fawzia Ibrahim
    Department of Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt
    Chem Cent J 5:11. 2011
    ..Method I involves condensation of the drug with mixed anhydrides (citric and acetic anhydrides) producing a product with intense fluorescence, which was measured at 496 nm after ..
  96. ncbi Synthesis and characterization of cis-4-decenoyl-CoA, 3-phenylpropionyl-CoA, and 2,6-dimethylheptanoyl-CoA
    Hany F Sobhi
    Center for Mitochondrial Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Anal Biochem 401:114-24. 2010
    ..Here we describe the synthesis of three medium-chain acyl-CoAs from mixed anhydrides of the fatty acids using an aqueous-organic solvent mixture optimized to obtain the highest yield...
  97. ncbi Perfluorosulfonic acid membrane catalysts for optical sensing of anhydrides in the gas phase
    Subasri M Ayyadurai
    Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, Ohio 45221, USA
    Anal Chem 82:6265-72. 2010
    ....
  98. pmc PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation
    Giuseppe Prencipe
    Department of Chemistry, Stanford University, Keck Science Building, Rm 125, 380 Roth Way, Stanford, California 94305, USA
    J Am Chem Soc 131:4783-7. 2009
    ..Additionally, the remaining carboxylic acids on gammaPGA or the amine-reactive anhydrides of PMHC18 are then PEGylated, providing extended hydrophilic groups, affording polymeric amphiphiles...
  99. ncbi Pre-column fluorescence derivatization using leucine-coumarnylamide for HPLC determination of mono- and dicarboxylic acids in plasma
    F Lévai
    Pharmacokinetic and Metabolism Laboratory, CHINOIN Pharmaceutical and Chemical Works Co Ltd, Budapest, Hungary
    Acta Physiol Hung 83:39-46. 1995
    ..Carboxylic acids form mixed anhydrides with ethyl chloroformate in the presence of triethylamine; the mixed anhydrides further react with L-leucine-4-..
  100. ncbi Synthesis and antitumor activity of some new xanthotoxin derivatives
    Omaima M Abdel Hafez
    Chemistry of Natural Product Department, National Research Center, Dokki, Cairo, Egypt
    Eur J Med Chem 44:2967-74. 2009
    ..On the other hand, the reaction of aminoxanthotoxin 1 with some anhydrides afforded 4-imidione derivatives 3a-d...
  101. ncbi A novel synthesis of succinic acid type Gemini surfactant by the functional group interconversion of Corynomicolic acid
    Tsunetomo Aisaka
    Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Kyoto, Japan
    J Oleo Sci 56:633-44. 2007
    ..After converting a mixture of syn- and anti-2,3-bis(undecyl)succinic acids to corresponding acid anhydrides, syn- and anti-anhydride isomers were separated by column chromatography, and by following hydrolysis syn- and ..

Research Grants19

  1. Optimization of Cure Efficiency in Polymeric Biomaterial
    Lawrence Musanje; Fiscal Year: 2006
    ..light source, 4) apply the developed visible light initiating system in polymerization of dimethacrylate anhydrides monomers...
  2. Complex Heterocycles and Hybrid Strategies for Pilot Scale Libraries
    Mark J Kurth; Fiscal Year: 2012
    ..1) 440 diverse lactams that emanate from multicomponent reactions and formal cycloadditions employing anhydrides, (2) 308 enantiomerically-pure 3-hydroxy-2-oxindoles and spirocyclic oxindole-oxazolines featuring ..
  3. IMMUNOTOXICITY OF ACID ANHYDRIDES IN THE LUNG
    JEAN REGAL; Fiscal Year: 1999
    DESCRIPTION: (Adapted from the Investigator's Abstract) Acid anhydrides, used in a number of industries, cause the immunotoxic response of allergy...
  4. PHOSPHATE ANALOG PROBES OF RED CELL METABOLISM
    Richard Labotka; Fiscal Year: 1990
    ..Two such small anions, acetyl phosphate (divalent) and methyl acetyl phosphate (monovalent) are reactive anhydrides capable of acetylation reactions near amino groups...
  5. DEVELOPMENT OF SITE SPECIFIC ANTISICKLING AGENTS
    Michael Johnson; Fiscal Year: 2000
    ..The secons approach will be based on a series of mixed phosphate anhydrides that are structurally related to BPG and are predicated to have a high affinity for its bindin site, providing ..
  6. STRUCTURE, DYNAMICS AND MECHANISM OF SERINE PROTEASES
    William Bachovchin; Fiscal Year: 1990
    ..of inhibitors: (a) peptide-boronic acids, (b) peptide-aldehydes, (c) peptide fluoromethylketones, (d) isotoic anhydrides, (e) protein-protease inhibitors. 2...
  7. Stereoselective Catalysis of the Asymmetric Desymmetrization of Meso Compounds
    Viktorya Aviyente; Fiscal Year: 2009
    ..understand the origins of the stereoselective nonenzymatic ring openings in the desymmetrization of meso cyclic anhydrides. The ultimate goal is to develop a theoretical understanding of the factors that control stereoselectivity and ..
  8. 3T Atherosclerotic MRI and Carotid Artery Scoring System
    Chun Yuan; Fiscal Year: 2009
    ....
  9. Development and validation of a woodsmoke biomarker in urine
    Christopher Simpson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. HETEROCYCLIC RING COMPOUNDS FOR ALKALOID SYNTHESIS
    Albert Padwa; Fiscal Year: 2007
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  11. Synthesis of New NNRTLs for the Treatment of AIDS
    Mark Cushman; Fiscal Year: 2005
    ..The activities of the ADAMs vs. NNRTI resistant viruses will be investigated. The aqueous solubilities of the new ADAMs will be measured accurately. ..
  12. Biological Monitoring of Woodsmoke exposure
    Christopher Simpson; Fiscal Year: 2003
    ..This proposed study addresses NORA research priorities related to asthma and COPD, exposure assessment methods and control technology/personal protective equipment. ..
  13. LTQ Linear Ion Trap Mass Spectrometer System
    Susan Weintraub; Fiscal Year: 2005
    ..Project descriptions for 9 major users, 4 minor users and 3 future users are presented. ..
  14. Chemical Mechanism of Guanine Deamination
    Rainer Glaser; Fiscal Year: 2003
    ..5. The computational studies will include studies of the bimolecular reaction mechanisms for dediazoniation of the nucleobase diazonium ions. ..
  15. IMPROVEMENT OF PREVENTIVE AND RESTORATIVE MATERIALS
    RAFAEL BOWEN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  16. Evaluation of urinary 1-nitropyrene metabolities as a biomarker for exposure to d
    Christopher Simpson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  17. LIGANDS FOR PROBING THE ACTIVE SITE OF LUMAZINE SYNTHASE
    Mark Cushman; Fiscal Year: 2008
    ..abstract_text> ..
  18. New Orally Active Agents for Cancer Prevention
    Tadashi Honda; Fiscal Year: 2004
    ..abstract_text> ..
  19. SYNTHESIS OF FUSED HETEROCYCLIC COMPOUNDS
    Albert Padwa; Fiscal Year: 2002
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..