fluoxetine

Summary

Summary: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

Top Publications

  1. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
  2. ncbi Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    Luca Santarelli
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 301:805-9. 2003
  3. ncbi The antidepressant fluoxetine restores plasticity in the adult visual cortex
    José Fernando Maya Vetencourt
    Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
    Science 320:385-8. 2008
  4. pmc Fear erasure in mice requires synergy between antidepressant drugs and extinction training
    Nina N Karpova
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    Science 334:1731-4. 2011
  5. ncbi Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells
    Dexiang Liu
    Institute of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong, PR China
    Neuropharmacology 61:592-9. 2011
  6. ncbi miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants
    Anne Baudry
    Cellules Souches, Signalisation et Prions, INSERM U747, Universite Paris Descartes, 75006 Paris, France
    Science 329:1537-41. 2010
  7. ncbi Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood-spinal cord barrier after spinal cord injury
    Jee Y Lee
    Age Related and Brain Diseases Research Centre, School of Medicine, Kyung Hee University, Seoul 130 701, Korea
    Brain 135:2375-89. 2012
  8. pmc Fluoxetine targets early progenitor cells in the adult brain
    Juan M Encinas
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:8233-8. 2006
  9. ncbi Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial
    Francois Chollet
    Neurology Department, Centre Hospitalier Universitaire de Toulouse, Hopital Purpan, Toulouse, France
    Lancet Neurol 10:123-30. 2011
  10. ncbi High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
    Raag D Airan
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 317:819-23. 2007

Detail Information

Publications351 found, 100 shown here

  1. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
    ..In corticosterone-treated mice where hippocampal neurogenesis is abolished by X-irradiation, the efficacy of fluoxetine is blocked in some, but not all, behavioral paradigms, suggesting both neurogenesis-dependent and -independent ..
  2. ncbi Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    Luca Santarelli
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 301:805-9. 2003
    ..Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor...
  3. ncbi The antidepressant fluoxetine restores plasticity in the adult visual cortex
    José Fernando Maya Vetencourt
    Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
    Science 320:385-8. 2008
    We investigated whether fluoxetine, a widely prescribed medication for treatment of depression, restores neuronal plasticity in the adult visual system of the rat...
  4. pmc Fear erasure in mice requires synergy between antidepressant drugs and extinction training
    Nina N Karpova
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    Science 334:1731-4. 2011
    ..Combining extinction training with chronic fluoxetine, but neither treatment alone, induced an enduring loss of conditioned fear memory in adult animals...
  5. ncbi Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells
    Dexiang Liu
    Institute of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong, PR China
    Neuropharmacology 61:592-9. 2011
    ..In the present study, using BV2 microglial cell line and primary microglial culture, we investigated if fluoxetine, the most widely used antidepressant, can inhibit microglia activation...
  6. ncbi miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants
    Anne Baudry
    Cellules Souches, Signalisation et Prions, INSERM U747, Universite Paris Descartes, 75006 Paris, France
    Science 329:1537-41. 2010
    ..In mice, chronic treatment with the SSRI fluoxetine (Prozac) increases miR-16 levels in serotonergic raphe nuclei, which reduces SERT expression...
  7. ncbi Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood-spinal cord barrier after spinal cord injury
    Jee Y Lee
    Age Related and Brain Diseases Research Centre, School of Medicine, Kyung Hee University, Seoul 130 701, Korea
    Brain 135:2375-89. 2012
    ..Recent evidence indicates that fluoxetine, an anti-depressant drug, is shown to have neuroprotective effects in ischaemic brain injury, but the precise ..
  8. pmc Fluoxetine targets early progenitor cells in the adult brain
    Juan M Encinas
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:8233-8. 2006
    ..We use this line to demonstrate that the selective serotonin reuptake inhibitor antidepressant fluoxetine does not affect division of stem-like cells in the dentate gyrus but increases symmetric divisions of an early ..
  9. ncbi Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial
    Francois Chollet
    Neurology Department, Centre Hospitalier Universitaire de Toulouse, Hopital Purpan, Toulouse, France
    Lancet Neurol 10:123-30. 2011
    ..Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that fluoxetine enhances motor recovery but its clinical efficacy is unknown...
  10. ncbi High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
    Raag D Airan
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 317:819-23. 2007
    ..Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms...
  11. pmc Chronic fluoxetine selectively upregulates dopamine D₁-like receptors in the hippocampus
    Katsunori Kobayashi
    Department of Pharmacology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
    Neuropsychopharmacology 37:1500-8. 2012
    ..We have recently demonstrated that the SSRI fluoxetine can reverse the state of maturation of the adult dentate granule cells and enhances serotonin 5-HT₄ receptor-..
  12. pmc Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence
    Ine Rayen
    Department of Neuroscience, School of Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 6:e24003. 2011
    ..Therefore, the aim of this study was to determine the role of exposure to fluoxetine during development on affective-like behaviors and hippocampal neurogenesis in adolescent offspring in a rodent ..
  13. ncbi Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
    Mark S Ansorge
    Sackler Institute for Developmental Psychobiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Science 306:879-81. 2004
    ..Transient inhibition of 5-HTT during early development with fluoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice...
  14. ncbi Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring
    Jocelien D A Olivier
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21 route 126, 6525, EZ, Nijmegen, The Netherlands
    Psychopharmacology (Berl) 217:419-32. 2011
    b>Fluoxetine (Prozac®) is the most frequently prescribed drug to battle depression in pregnant women, but its safety in the unborn child has not yet been established...
  15. ncbi Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration
    Quentin Rainer
    Equipe d Accueil 3544, Laboratoire de Neuropharmacologie, Universite Paris XI, Chatenay Malabry, France
    Mol Pharmacol 81:106-12. 2012
    ..Here we assessed the effects of sustained administration of the SSRI fluoxetine on 5-HT(1A) autoreceptor sensitivity in mice administered with corticosterone...
  16. ncbi The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review
    J D A Olivier
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Dept of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 GA Nijmegen, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 35:1400-8. 2011
    The selective serotonin reuptake inhibitor (SSRI) Prozac® (fluoxetine) is widely prescribed for the treatment of depression and anxiety-related disorders...
  17. pmc Fluoxetine induced suicidal erythrocyte death
    Kashif Jilani
    Department of Physiology, University of Tuebingen, Gmelinstr 5, Tuebingen 72076, Germany
    Toxins (Basel) 5:1230-43. 2013
    The antidepressant fluoxetine inhibits ceramide producing acid sphingomyelinase...
  18. pmc Reversal of hippocampal neuronal maturation by serotonergic antidepressants
    Katsunori Kobayashi
    Department of Pharmacology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Proc Natl Acad Sci U S A 107:8434-9. 2010
    ..Here we show a distinct unique action of the serotonergic antidepressant fluoxetine in transforming the phenotype of mature dentate granule cells...
  19. ncbi Effects of chronic fluoxetine in animal models of anxiety and depression
    Stephanie C Dulawa
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 29:1321-30. 2004
    ..mouse strains for their behavioral response to chronic treatment with the selective-serotonin reuptake inhibitor fluoxetine (0, 5, 10 mg/kg/day in drinking water), which is used for the treatment of mood and anxiety disorders...
  20. pmc Fluoxetine-induced cortical adult neurogenesis
    Koji Ohira
    Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    Neuropsychopharmacology 38:909-20. 2013
    ..Here, we show that chronic treatment with an SSRI, fluoxetine (FLX), stimulated the neurogenesis of γ-aminobutyric acid (GABA)ergic interneurons from L1-INP cells in the ..
  21. ncbi Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice
    S H Christiansen
    Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and Department of Neuroscience and Pharmacology, Rigshospitalet O 6102, University of Copenhagen, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Behav Brain Res 216:585-91. 2011
    ..in brains of mice subjected to chronic restraint stress (CRS) and concomitant treatment with the antidepressant fluoxetine (FLX)...
  22. ncbi Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells
    Jing Wen Wang
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 28:1374-84. 2008
    ..Here we examined the effects of subchronic and chronic fluoxetine on the structural and physiological properties of young granule cells...
  23. ncbi Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome
    Patrizia Bianchi
    Department of Human and General Physiology, University of Bologna, I 40126 Bologna, Italy
    J Neurosci 30:8769-79. 2010
    ..Neonate Ts65Dn mice were treated from postnatal day (P) 3 to P15 with fluoxetine, an antidepressant that inhibits serotonin (5-HT) reuptake and increases proliferation in the adult Ts65Dn mouse ..
  24. ncbi Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat
    Masafumi Kodama
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 56:570-80. 2004
    ..There has been increasing evidence that atypical antipsychotics are effective in the treatment of mood disorders or for augmenting 5-hydroxytryptamine selective reuptake inhibitors for treatment-resistant depression...
  25. ncbi The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
    J M Bessa
    Life and Health Science Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Mol Psychiatry 14:764-73, 739. 2009
    ..In the last 2 weeks of stress exposure, animals were treated with the antidepressants fluoxetine, imipramine, CP 156,526 or SSR 1494515, alone or combined with methylazoxymethanol, a cytostatic agent used to ..
  26. ncbi Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trial
    John March
    Duke Clinical Research Institute, Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 292:807-20. 2004
    ..Initial treatment of major depressive disorder in adolescents may include cognitive-behavioral therapy (CBT) or a selective serotonin reuptake inhibitor (SSRI). However, little is known about their relative or combined effectiveness...
  27. ncbi Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment
    Jessica E Malberg
    Wyeth Neuroscience, Princeton, NJ, USA
    Neuropsychopharmacology 28:1562-71. 2003
    ..Administration of fluoxetine, a serotonin selective reuptake inhibitor, from days 2-8 blocked the downregulation of cell proliferation ..
  28. ncbi Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression
    R Alonso
    Sanofi Synthelabo Recherche, Rue du Professeur J Blayac, Montpellier, France
    Mol Psychiatry 9:278-86, 224. 2004
    ..antagonist SSR125543A, the V(1b) receptor antagonist SSR149415, and the clinically effective antidepressant fluoxetine may influence newborn cell proliferation and differentiation in the dentate gyrus of mice subjected to the ..
  29. ncbi Prevalence and patterns of antidepressant drug use during pregnancy
    Tessa Ververs
    Department of Clinical Pharmacy, Clinical Chemistry and Laboratory Medicine, University Medical Center UMC Utrecht, Utrecht, The Netherlands
    Eur J Clin Pharmacol 62:863-70. 2006
    ..The aim of this study was to determine the extent and patterns of antidepressant use before, during and after pregnancy in a large population in The Netherlands...
  30. pmc Suicidal thoughts and behavior with antidepressant treatment: reanalysis of the randomized placebo-controlled studies of fluoxetine and venlafaxine
    Robert D Gibbons
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Arch Gen Psychiatry 69:580-7. 2012
    ..The US Food and Drug Administration issued a black box warning for antidepressants and suicidal thoughts and behavior in children and young adults...
  31. ncbi Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors
    L Conboy
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Mol Psychiatry 16:533-47. 2011
    ..These findings underscore MIF as a potentially relevant molecular target for the development of treatments linked to deficits in neurogenesis, as well as to problems related to anxiety, depression, and cognition...
  32. pmc Benefits from antidepressants: synthesis of 6-week patient-level outcomes from double-blind placebo-controlled randomized trials of fluoxetine and venlafaxine
    Robert D Gibbons
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Arch Gen Psychiatry 69:572-9. 2012
    ..Some meta-analyses suggest that efficacy of antidepressants for major depression is overstated and limited to severe depression...
  33. ncbi Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment
    Valentine Bouet
    Groupe Mémoire et Plasticité Comportementale GMPc, Universite de Caen Basse Normandie, Caen, France
    Psychopharmacology (Berl) 221:329-39. 2012
    Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are increasingly used for the treatment of depression in children...
  34. ncbi Prenatal fluoxetine exposure induces life-long serotonin 5-HT₃ receptor-dependent cortical abnormalities and anxiety-like behaviour
    Laura A Smit-Rigter
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, P O Box 94232, 1090 GE Amsterdam, The Netherlands
    Neuropharmacology 62:865-70. 2012
    ..Here we show that in mice, the adverse effects of the widely used antidepressant and SSRI fluoxetine are critically dependent on the 5-HT(3) receptor, the only ligand-gated ion channel in the family of serotonin ..
  35. ncbi Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pups
    Ying Chao Chang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Guang University College of Medicine, Kaohsiung, Taiwan
    Neurobiol Dis 24:101-13. 2006
    ..Chronic treatment of fluoxetine, a selective serotonin reuptake inhibitor, can upregulate CREB activation in the hippocampus...
  36. ncbi Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation
    Young C Chung
    Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Neuropharmacology 60:963-74. 2011
    ..Here, we report that fluoxetine, one of the most commonly prescribed antidepressants, prevents MPTP-induced degeneration of nigrostriatal DA ..
  37. ncbi Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment
    M Fava
    Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 61:863-7. 2000
    ..Also unknown is whether different agents have differential effects. To examine these questions, we assessed weight changes in patients randomly assigned to long-term treatment with fluoxetine, sertraline, or paroxetine.
  38. ncbi Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Neuropsychopharmacology 31:1616-26. 2006
    ..Additionally, we examined whether antidepressant treatment with fluoxetine, a selective serotonin reuptake inhibitor, offered protection from these stress-induced effects...
  39. ncbi Neonatal fluoxetine exposure affects the neuronal structure in the somatosensory cortex and somatosensory-related behaviors in adolescent rats
    Li Jen Lee
    Department of Anatomy, College of Medicine, National Taiwan University, No 1, Ren Ai Rd, Section 1, Taipei 100, Taiwan
    Neurotox Res 15:212-23. 2009
    ..In this study, we examined the effects of early exposure of fluoxetine, the most popular SSRI-type antidepressant, on the developing somatosensory system...
  40. ncbi Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes
    Igor Allaman
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, CH 1015, Switzerland
    Psychopharmacology (Berl) 216:75-84. 2011
    ..During therapeutic treatment for major depression, fluoxetine, one of the most commonly prescribed selective serotonin reuptake inhibitor (SSRI) antidepressants, accumulates ..
  41. ncbi Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus
    Jan A Mennigen
    Centre for Advances Research in Environmental Genomics, Department of Biology, University of Ottawa, Ontario, Canada
    Aquat Toxicol 100:354-64. 2010
    b>Fluoxetine (FLX) is a pharmaceutical acting as a selective serotonin reuptake inhibitor and is used to treat depression in humans...
  42. ncbi Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment
    C Song
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada
    Pharmacopsychiatry 42:182-8. 2009
    ..between pro- and anti-inflammatory cytokines and between Th1 and Th2 produced cytokines in depressed patients and 2) evaluate and compare the effect of treatments with electroacupuncture (EA) and fluoxetine on these cytokines.
  43. doi Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ mice
    G J Huang
    Mol Psychiatry 13:119-21. 2008
  44. ncbi Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil
    Maha ElBeltagy
    Department of Anatomy, Menoufiya University, Egypt
    Behav Brain Res 208:112-7. 2010
    ..reports indicate that hippocampal dependent neurogenesis and cognition are enhanced by the SSRI antidepressant Fluoxetine. In this investigation the behavioural effects of chronic (two week) treatment with 5-FU and (three weeks) with ..
  45. ncbi Short-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus
    Tibor Hajszan
    Department of Obstetrics, Gynaecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, FMB 312, New Haven, CT 06520 8063, USA
    Eur J Neurosci 21:1299-303. 2005
    ..Here we provide evidence that daily administration of the antidepressant fluoxetine to ovariectomized female rats for 5 days induces a robust increase in pyramidal cell dendritic spine synapse ..
  46. ncbi Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus
    Mikko Sairanen
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 25:1089-94. 2005
    ..Furthermore, we observed that chronic treatment with imipramine or fluoxetine produced a temporally similar increase in both BrdU-positive and terminal deoxynucleotidyl transferase-mediated ..
  47. ncbi Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Neuropsychopharmacology 32:1490-503. 2007
    ..subjected to 5 weeks of daily social defeat by an aggressive conspecific and received concomitant, daily, oral fluoxetine (10 mg/kg) during the last 4 weeks...
  48. ncbi Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior
    Daniela Popa
    Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S677, F 75013 Paris, France
    J Neurosci 28:3546-54. 2008
    ..Such early-life impairments might predispose individuals to sleep and/or mood disorders...
  49. ncbi Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine
    R Ranganathan
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 21:5871-84. 2001
    ..elegans. The selective serotonin reuptake inhibitor fluoxetine (Prozac) potentiated the enhanced slowing response, and this potentiation required mod-5 function, establishing ..
  50. ncbi Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex
    Frank P Bymaster
    Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Psychopharmacology (Berl) 160:353-61. 2002
    The selective serotonin uptake inhibitor (SSRI) fluoxetine has been shown to not only increase the extracellular concentrations of serotonin, but also dopamine and norepinephrine extracellular concentrations in rat prefrontal cortex...
  51. pmc Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice
    Koji Ohira
    Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    Mol Brain 4:10. 2011
    ..Since almost all of those studies treated animals with drugs for 2 to 4 weeks as chronic treatment models of antidepressants, it is possible that antidepressant treatments for longer periods would affect adult neurogenesis in the SVZ...
  52. ncbi Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain
    Suzanne Cassel
    Unité INSERM U575, Centre de Neurochimie, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France
    Mol Pharmacol 70:487-92. 2006
    ..protein MBD1, were significantly induced in normal adult rat brain after repeated injections of fluoxetine or cocaine for 10 days (one injection per day)...
  53. ncbi Reduced hippocampal neurogenesis and number of hilar neurones in streptozotocin-induced diabetic mice: reversion by antidepressant treatment
    Juan Beauquis
    Laboratory of Neuroendocrine Biochemistry, Institute of Biology and Experimental Medicine, National Research Council Argentina, Obligado 2490 1428 Buenos Aires, Argentina
    Eur J Neurosci 23:1539-46. 2006
    ..is also deficient in diabetic mice, which led us to study whether the selective serotonin reuptake inhibitor fluoxetine influences cell proliferation in streptozotocin-diabetic animals...
  54. ncbi Cognitive therapy versus fluoxetine in generalized social phobia: a randomized placebo-controlled trial
    David M Clark
    Department of Psychology, Institute of Psychiatry, London, United Kingdom
    J Consult Clin Psychol 71:1058-67. 2003
    ..Psychiatric Association, 1994) criteria for generalized social phobia were assigned to cognitive therapy (CT), fluoxetine plus self-exposure (FLU + SE), or placebo plus self-exposure (PLA + SE)...
  55. ncbi Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone
    Guo Jen Huang
    Department of Anatomy and Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Biol Psychiatry 59:619-24. 2006
    b>Fluoxetine stimulates proliferation of progenitor cells in the dentate gyrus of the adult hippocampus. There are suggestions that this action may underlie the therapeutic effects of such drugs in depression...
  56. ncbi Treatment of resistant human colon cancer xenografts by a fluoxetine-doxorubicin combination enhances therapeutic responses comparable to an aggressive bevacizumab regimen
    Mirit Argov
    Department of Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Lett 274:118-25. 2009
    ..purpose of this study was to characterize moderate drug resistance in human colon cancer, and it's modulation by fluoxetine. In vitro fluoxetine enhanced doxorubicin's cytotoxicity (10-fold), increased doxorubicin's intracellular ..
  57. pmc Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine
    Katsunori Kobayashi
    Department of Pharmacology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Mol Brain 4:12. 2011
    ..We have recently shown that the SSRI fluoxetine can reverse the state of maturation of hippocampal granule cells in adult mice...
  58. ncbi Behavioral and biochemical responses of hybrid striped bass during and after fluoxetine exposure
    Kristen M Gaworecki
    Institute of Environmental Toxicology, Department of Biological Sciences, Clemson University, Pendleton, SC 29670, United States
    Aquat Toxicol 88:207-13. 2008
    ..One important behavior that could be impacted is the ability to capture prey. We hypothesized that sublethal fluoxetine exposure may lead to feeding behavior abnormalities in hybrid striped bass (Morone saxatilis x M. chrysops)...
  59. ncbi The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma
    Suzanne M Cloonan
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Int J Cancer 128:1712-23. 2011
    ..We report that the antidepressants maprotiline and fluoxetine induce autophagic PCD in the chemoresistant Burkitt's lymphoma (BL) cell line DG-75, which does not involve ..
  60. ncbi Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder
    Nayereh Khoraminya
    Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Aust N Z J Psychiatry 47:271-5. 2013
    To compare the therapeutic effects of vitamin D3 plus fluoxetine and fluoxetine alone in patients with major depressive disorder.
  61. ncbi Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice
    Fraser Murray
    Merck Sharp and Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR United Kingdom
    Eur J Pharmacol 583:115-27. 2008
    ..We have also examined the effects of chronic administration of fluoxetine and imipramine on these parameters...
  62. ncbi Pharmacokinetics of selective serotonin reuptake inhibitors
    C Hiemke
    Department of Psychiatry, University of Mainz, Germany
    Pharmacol Ther 85:11-28. 2000
    The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect profile...
  63. ncbi Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in mice
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Hippocampus 17:175-80. 2007
    ..Both male and female mice had a greater number of BrdU-immunoreactive SGZ cells following chronic treatment with fluoxetine. This demonstrates a parallel proliferation response in both genders, and opens avenues for addressing the ..
  64. ncbi Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress
    Seiji Hitoshi
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, Japan
    J Neurosci Res 85:3574-85. 2007
    ..persisted for weeks after the cessation of stress but was reversed by treatment with the antidepressant drugs fluoxetine and imipramine...
  65. ncbi A randomized, double-blind comparison of olanzapine/fluoxetine combination, olanzapine, and fluoxetine in treatment-resistant major depressive disorder
    Michael E Thase
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 68:224-36. 2007
    Two parallel, 8-week double-blind studies compared olanzapine/fluoxetine combination, olanzapine, and fluoxetine in outpatients with treatment-resistant depression (TRD).
  66. pmc Stepped care and cognitive-behavioural therapy for bulimia nervosa: randomised trial
    James E Mitchell
    Neuropsychiatric Research Institute, 120 South 8th Street, Fargo, North Dakota 58103, USA
    Br J Psychiatry 198:391-7. 2011
    This study compared the best available treatment for bulimia nervosa, cognitive-behavioural therapy (CBT) augmented by fluoxetine if indicated, with a stepped-care treatment approach in order to enhance treatment effectiveness.
  67. ncbi The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression
    Maya First
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, 49100 Petah Tikva, Israel
    J Mol Neurosci 45:246-55. 2011
    ..We evaluated the effect of CMS and the selective serotonin reuptake inhibitor, fluoxetine (FLX) treatment on behavioral and cognitive parameters in rats, and on HC and frontal cortex (FC) neurotrophic ..
  68. ncbi Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception
    J X Chen
    Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Am J Physiol 275:G433-48. 1998
    ..cell-1 . min-1), Na+-dependent mechanism that was inhibited by chlorimipramine > imipramine > fluoxetine > desipramine > zimelidine...
  69. pmc BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell, New York, NY 10021, USA
    Neuropsychopharmacology 37:1297-304. 2012
    ..anxiety-like behaviors that are not rescued with the prototypic selective serotonin reuptake inhibitor (SSRI), fluoxetine. A prominent hypothesis is that SSRI-induced augmentation of BDNF protein expression and the beneficial trophic ..
  70. ncbi Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion
    Cristiano R Jesse
    Laboratorio de Sintese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, CEP 97105 900, Santa Maria, RS, Brazil
    Psychopharmacology (Berl) 212:513-22. 2010
    ..Pain co-morbidity symptoms are rarely assessed in animal models of neuropathic pain. Neuropathic pain is characterized by hyperexcitability within nociceptive pathways and remains difficult to treat with standard analgesics...
  71. ncbi Uptake and depuration of the anti-depressant fluoxetine by the Japanese medaka (Oryzias latipes)
    Gordon Paterson
    Worsfold Water Quality Centre, Trent University, Peterborough, Ontario, Canada
    Chemosphere 74:125-30. 2008
    ..In this study, Japanese medaka (Oryzias latipes) were exposed to fluoxetine at a nominal concentration of 0...
  72. ncbi Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice
    Eleni Paizanis
    INSERM UMR S677, F 75013 Paris, France
    Int J Neuropsychopharmacol 13:759-74. 2010
    ..agonist/5-HT(2C) receptor antagonist, agomelatine, compared to the selective 5-HT reuptake inhibitor (SSRI), fluoxetine, on hippocampal neurogenesis, GR and BDNF expression and antidepressant-responsive behaviour (tail suspension ..
  73. ncbi Pharmaceuticals as neuroendocrine disruptors: lessons learned from fish on Prozac
    Jan A Mennigen
    Centre for Advanced Research in Environmental Genomics and Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 14:387-412. 2011
    ..One of the most prevalent environmental pharmaceuticals in North America and Europe is the antidepressant fluoxetine, a selective serotonin reuptake inhibitor (SSRI) and the active ingredient of Prozac...
  74. pmc Anti-inflammatory properties of desipramine and fluoxetine
    Caroline Roumestan
    INSERM, U454, Montpellier, France
    Respir Res 8:35. 2007
    ..We also analysed whether antidepressants act directly on peripheral cell types that participate in the inflammatory response in these diseases...
  75. ncbi Effects of chronic fluoxetine treatment on the rat somatosensory cortex: activation and induction of neuronal structural plasticity
    R Guirado
    Cell Biology Department, Neurobiology Unit and Program in Basic and Applied Neurosciences, Universitat de Valencia, Spain
    Neurosci Lett 457:12-5. 2009
    ..In a previous report we found that chronic fluoxetine treatment increases the expression of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), a ..
  76. ncbi Are all antidepressants really the same? The case of fluoxetine: a systematic review
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    J Clin Psychiatry 67:850-64. 2006
    To systematically review the efficacy and tolerability of fluoxetine, the most widely studied of newer antidepressants, in comparison with all other antidepressants in the acute treatment of depression in patients aged more than 18 years.
  77. ncbi Fluoxetine (Prozac) interaction with the mitochondrial voltage-dependent anion channel and protection against apoptotic cell death
    Edna Nahon
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    FEBS Lett 579:5105-10. 2005
    b>Fluoxetine (Prozac) is a potent antidepressant compound inhibiting serotonin reuptake, but also Na+, K+ and Ca2+ channels and reported to both trigger and prevent apoptosis...
  78. ncbi Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects
    A Bortolozzi
    Department of Neurochemistry and Neuropharmacology, IIBB CSIC IDIBAPS, Barcelona, Spain
    Mol Psychiatry 17:612-23. 2012
    ..Moreover, i.c.v. C-1A-siRNA infusion augmented the increase in extracellular serotonin evoked by fluoxetine in prefrontal cortex to the level seen in 5-HT(1A)R knockout mice...
  79. ncbi Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats
    Murray R Thompson
    School of Psychology, University of Sydney, NSW, Australia
    Neuropsychopharmacology 29:694-704. 2004
    ..The present study examined whether chronic treatment with the antidepressant drug fluoxetine could reverse such effects...
  80. ncbi Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring
    J L Pawluski
    School for Mental Health and Neuroscience, Department of Neuroscience, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Neuroscience 220:131-41. 2012
    ..Therefore, the aim of the present study was to determine how maternal fluoxetine treatment affects the developing HPA system of adolescent male and female offspring using a model of maternal ..
  81. pmc Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, β-catenin and antidepressant-like effects
    F Pilar-Cuéllar
    Departamento de Fisiologia y Farmacologia, Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, Universidad de Cantabria CSIC IDICAN, Santander, Cantabria, Spain
    Br J Pharmacol 165:1046-57. 2012
    ..Here, we have studied the involvement of neuroplasticity pathways and/or the 5-hydroxytryptaminergic system in the antidepressant-like effect of this combined treatment, given subchronically...
  82. pmc Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine
    Zaorui Zhao
    Graduate Program in Pharmaceutical and Pharmacological Sciences, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Neuropsychopharmacology 33:3190-200. 2008
    ..Understanding the mechanisms underlying NET regulation in vivo may suggest novel targets for therapeutic intervention in the treatment of depression...
  83. ncbi Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Arch Gen Psychiatry 60:1079-88. 2003
    ....
  84. pmc Fluoxetine treatment of alcoholic perpetrators of domestic violence: a 12-week, double-blind, randomized, placebo-controlled intervention study
    David T George
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bldg 10, Clinical Research Center, 10 Center Drive, Bethesda, MD 20892 1540, USA
    J Clin Psychiatry 72:60-5. 2011
    ..This score served as a surrogate marker for the anger and physical aggression that characterize perpetrators of IPV...
  85. ncbi Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex
    E Ampuero
    Laboratorio de Neurociencias, Universidad de Los Andes, Santiago, Chile
    Neuroscience 169:98-108. 2010
    ..To gain further insight into these changes in the cerebral cortex, rats were treated with fluoxetine (flx) for 4 weeks. These animals showed decreased anxiety and learned helplessness...
  86. ncbi Comparison of the effects of fluoxetine, imipramine and placebo on personality in atypical depression
    Vito Agosti
    New York State Psychiatric Institute, Unit 35, 1051 Riverside Drive, New York, NY 10032, USA
    J Affect Disord 71:113-20. 2002
    ..Studies have confirmed the efficacy of a several antidepressants in the treatment of atypical depression. Whether their pathological dimensions of personality diminish after benefitting from effective medication treatment is unclear...
  87. ncbi Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout mice
    Martin Egeland
    Center for Molecular Medicine, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 67:1048-56. 2010
    ..Because chronic treatment with antidepressants also upregulates p11, we hypothesized that p11 might regulate effects of antidepressants on aspects of neurogenesis...
  88. ncbi Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor
    Kerri A Holick
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 33:406-17. 2008
    ..reported that chronic, but not subchronic, treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine altered behavior in the forced swimming test (FST) in BALB/cJ mice...
  89. ncbi Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats
    Henry A Nasrallah
    Dept of Psychiatry, Univ of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Brain Res 1354:23-9. 2010
    ..Young adult male rats were treated with risperidone and paliperidone, atypical antipsychotic medications; fluoxetine, a selective serotonin reuptake inhibitor (SSRI) antidepressant; and diluent control for 28days via drinking ..
  90. pmc Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 101:6222-5. 2004
    ..In these mice, the PTB-induced loss of righting reflex is greatly reduced. Fluoxetine (FLX) and norfluoxetine (NFLX) stereospecifically reverse the effect of social isolation on the PTB-induced loss ..
  91. ncbi Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in rats
    Feng Guo Zhai
    Department of Clinical Pharmacology, China Medical University, Shenyang, China
    Clin Exp Pharmacol Physiol 36:850-6. 2009
    ..5 channels and apoptosis in the protective effect of the SSRI fluoxetine against PAH. 2. Monocrotaline (MCT) was used to establish PAH in Wistar rats...
  92. ncbi Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats
    Shao Ping Zhu
    Department of Cardiothoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China
    Clin Exp Pharmacol Physiol 36:e1-5. 2009
    ..Thus, the aim of the present study was to investigate the short- and long-term effects of fluoxetine on monocrotaline (MCT)-induced PAH and associated pathophysiological changes in PAH models. 2...
  93. ncbi Effects of olanzapine alone and olanzapine/fluoxetine combination on health-related quality of life in patients with bipolar depression: secondary analyses of a double-blind, placebo-controlled, randomized clinical trial
    Lizheng Shi
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Clin Ther 26:125-34. 2004
    ..Improving patients' health-related quality of life (HRQOL) could be a treatment goal for bipolar depression...
  94. pmc Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography
    D P Uzunov
    Department of Psychiatry, University of Illinois at Chicago 60612, USA
    Proc Natl Acad Sci U S A 93:12599-604. 1996
    b>Fluoxetine administered intraperitoneally to sham-operated or adrenalectomized/castrated (ADX/CX) male rats dose-dependently (2.9-58 mumol/kg i.p...
  95. pmc Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus
    Nicola D Hanson
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 337:180-6. 2011
    ..We found no effect of the selective serotonin reuptake inhibitor fluoxetine or the corticotropin-releasing factor receptor 1 antagonist R121919 [3-[6-(dimethylamino)-4-methylpyridin-3-yl]-..
  96. ncbi Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats
    A B Marcussen
    Department of Pharmacology Target Research, H Lundbeck A S, Valby, Denmark
    Acta Neurol Scand 117:94-100. 2008
    ....
  97. ncbi Approximate entropy of symptoms of mood: an effective technique to quantify regularity of mood
    Vikram K Yeragani
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA
    Bipolar Disord 5:279-86. 2003
    ..In this study, we investigated regularity of mood using APEN (Approximate Entropy) on daily subjective ratings using a Visual Analog Scale with 11 items pertaining to mood...
  98. pmc Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy
    Laura Lyons
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Psychopharmacology (Berl) 215:105-15. 2011
    ..It is postulated that these impairments are due to these drugs targeting neural precursors within the adult hippocampus, the loss of which has been associated with memory impairment...
  99. ncbi Memory impairment in patients with late-onset major depression: the effect of antidepressant therapy
    Roberto Gallassi
    Centre for the Neurological Study of Cerebral Aging, Department of Neurological Sciences, University of Bologna, Italy
    J Affect Disord 91:243-50. 2006
    ..Cognitive deficits have been described in patients with major depression (MD), although many aspects remain unsettled...
  100. pmc Paradoxical anxiogenic response of juvenile mice to fluoxetine
    Ji Eun Oh
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neuropsychopharmacology 34:2197-207. 2009
    ..b>Fluoxetine (Prozac) is the first approved SSRI for the treatment of depression in this population...
  101. pmc Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams
    Josephine M Johns
    Department of Psychiatry, The University of North Carolina at Chapel Hill, 424 Taylor Hall, CB 7096, Chapel Hill, NC 27599 7096, USA
    Int J Dev Neurosci 22:321-8. 2004
    ..were determined for lactating rat dams on postpartum day 6 (PPD 6) that were gestationally treated with cocaine, fluoxetine, saline or an amfonelic acid/fluoxetine drug combination...

Research Grants71

  1. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2013
    ..exhibit antidepressant-like effects, or enhance the therapeutic effect of a conventional antidepressant such as fluoxetine. Based on these findings, it is assumed that drug induced hyperacetylation of histones and the resulting ..
  2. Serotonin Receptor Modulation of Neurotrophic Factors in the Retina
    Mark E Pennesi; Fiscal Year: 2013
    ..SSRIs, such as fluoxetine or paroxetine, have been widely and safely used to treat a number of psychiatric diseases such as depression and ..
  3. Memory and Mood Enhancing Therapies for Gulf War Illness
    Ashok K Shetty; Fiscal Year: 2013
    ..Indeed, our preliminary studies suggest that administration of antidepressants such as fluoxetine (FLU) or rolipram (ROL) after a combined exposure to chemicals (PB+DEET+Permethrin) and stress has promise for ..
  4. Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood Depression
    Mary A Fristad; Fiscal Year: 2013
    ..A recent meta-analysis found fluoxetine to be the only antidepressant medication with significant empirical support for decreasing depression in ..
  5. The Role of HIF-1 in Neurogenic and Behavior Responses to Antidepressants.
    W TIMOTHY O'BRIEN; Fiscal Year: 2013
    ..signaling, is required for the effects of lithium and the antidepressants, imipramine and fluoxetine on behavior...
  6. GABA-active neurosteroids in contextual fear responses
    Graziano Pinna; Fiscal Year: 2011
    ..excessive contextual fear responses can be normalized by administering neurosteroidogenic drugs, including fluoxetine (FLX) (PNAS 105, 5567-5572. 2008) at doses too low to inhibit serotonin reuptake (Curr Opin Pharmacol 9, 24- 30...
  7. Behavioral and Molecular Effects of Antenatal SSRI Exposure
    Lawrence S Quang; Fiscal Year: 2013
    ..The proposed experiments will entail antenatal exposure of pregnant ePet-EYFP mice with the SSRI, fluoxetine. Subsequently, phenotypes of offspring will be examined using behavioral assays and molecular techniques...
  8. Serotonergic Contribution to Adolescent Risk Taking
    ANDREW EMMETT ARRANT; Fiscal Year: 2012
    ..to the anxiogenic effects of the serotonin releaser fenfluramine (2 mg/kg) and the serotonin reuptake inhibitor fluoxetine (10 mg/kg) in the light/dark (LD) test...
  9. Bupropion for Depression in ESRD Patients on Hemodialysis
    Pedro L Delgado; Fiscal Year: 2013
    ..treatment of MDD in ESRD/HD patients have mostly used the selective serotonin reuptake inhibitor (SSRI) fluoxetine and there is some evidence of efficacy...
  10. Epigenetic modulation of antidepressant efficacy
    Claudia Schmauss; Fiscal Year: 2013
    ..Strikingly, adolescent fluoxetine treatment of ELS Balb/c mice exerted powerful antidepressant effects and further elevated levels of acetylated ..
  11. 1/3-Reducing Suicial Ideation Through Insomnia Treatment (REST-IT)
    WILLIAM VAUGHN MCCALL; Fiscal Year: 2013
    ..We have unpublished, preliminary data showing that the addition of the hypnotic eszopiclone to open-label fluoxetine in the treatment of depressed insomniacs is associated with a reduction in suicidal ideation, as compared with ..
  12. Use of a mouse model of anxious depression to assess the safety of pediatric anti
    Bernhard Luscher; Fiscal Year: 2010
    ..In particular, treatment of children and adolescents with antidepressant drugs such as fluoxetine may result in increased suicidal behavior and lethality...
  13. Mechanisms of Drug Induced Phospholipidosis
    JAMES ALAN SHAYMAN; Fiscal Year: 2013
    ..Specific examples of agents that cause phospholipidosis include, but are not limited to, azithromycin, fluoxetine, amiodarone, chloroquine, imipramine, and ketoconazole...
  14. Processing of emotional content and brain activation in adolescents treated with
    GIOVANNI TIRADO SANTIAGO; Fiscal Year: 2010
    ..a R15 that seeks to examine the relationship between a) the efficacy of cognitive behavioral therapy (CBT) and fluoxetine treatment in adolescents with a positive diagnosis for major depressive disorder (MDD), and b) brain structure ..
  15. Medications and the Risk of Sudden Cardiac Death
    Wayne A Ray; Fiscal Year: 2013
    ..studies and case reports of torsade de pointes suggest four specific widely used antidepressants--fluoxetine, citalopram, escitalopram, and trazodone--may increase risk of sudden cardiac death...
  16. Mechanisms Underlying Treatment-Resistant Depression and Anxiety in Mouse Models
    Benjamin A Samuels; Fiscal Year: 2013
    ..we will fully examine the role of TGFbeta signaling in the dentate gyrus in mediating the effects of fluoxetine, and ask if activation of TGFbeta signaling is capable of converting non-responders to treatment into responders...
  17. CRCNS: Computational Model for Neural Stem Cell Divisions in the Adult Brain
    Alexei Koulakov; Fiscal Year: 2013
    ..For instance, an antidepressant drug fluoxetine (Prozac) enhances, whereas aging decreases, hippocampal neurogenesis...
  18. In vitro and in vivo study of simvastatin plus lithium in bipolar depression
    Roy H Perlis; Fiscal Year: 2013
    ..A recent rodent study found evidence that a statin augmented the antidepressant-like effects with fluoxetine. Intriguingly, multiple population-based studies also suggest that statins may be associated with a ..
  19. PSYCHOSTIMULANT RECOGNITION BY SEROTONIN TRANSPORTERS
    Eric L Barker; Fiscal Year: 2010
    ..most antidepressant drugs as well as many drugs of abuse. Antidepressants such as paroxetine, fluoxetine, and imipramine bind to the transporter and inhibit serotonin uptake, thereby prolonging the extracellular ..
  20. Serotonin and the Modulation of Brain Development
    Jay A Gingrich; Fiscal Year: 2012
    ..of genetically-impaired SERT mice are recapitulated by early life exposure to SERT-blocking agents such as fluoxetine, clomipramine, and citalopram...
  21. Muscle function and depression-like behavior in a mouse model of cancer fatigue
    LOREN EUGENE WOLD; Fiscal Year: 2013
    ..expression;ibuprofen to reduce the activity of a downstream mediator of TNFa-induced skeletal muscle wasting;fluoxetine, a selective serotonin reuptake inhibitor (SSRI) , or 1-methyl tryptophan, a competitive antagonist of ..
  22. Functional characterization of SSRI resistant genes using C. elegans
    JI Y SZE; Fiscal Year: 2010
    ..This proposal is based on our preliminary data indicating that the SSRI fluoxetine (Prozac ) targets serotonin postsynaptic targets to regulate the activity of acetylcholine, GABA, and glutamate ..
  23. Serotonin Reuptake Inhibitors and 5-HT1A Receptors
    George Battaglia; Fiscal Year: 2009
    ..In neuroendocrine neurons in the adult hypothalamus, fluoxetine (Prozac(R)) and other serotonin-selective reuptake inhibitors (SSRIs) desensitize 5-HT1A activation of plasma ..
  24. OCT Blockade to Restore Sociability in 5-HT Transporter Knock-Out Mice
    Georgianna G Gould; Fiscal Year: 2012
    ..Drug interventions for these disorders, such as risperidone (Risperdal) and fluoxetine (Prozac), commonly enhance 5-HT neurotransmission or mimic its downstream effects, but these interventions often ..
  25. 1/2-Prevention of Relapse &Recurrence of Bipolar Depression
    Robert J Derubeis; Fiscal Year: 2013
    ..In this application, we will ask: "Does continuation therapy with combined lithium plus fluoxetine result in fewer MDE relapses and recurrences vs...
  26. Development of rat models of the effort-related symptoms of depression
    John D Salamone; Fiscal Year: 2013
    ..of a novel treatment strategy for depression (adenosine A2A antagonists) and two well known drugs (bupropion and fluoxetine), using behavioral models of effort-related function...
  27. Family Therapy in the Treatment of Adolescent Anorexia Nervosa
    D Blake Woodside; Fiscal Year: 2010
    ..Additionally, there is preliminary evidence that fluoxetine may be useful in reducing comorbid psychopathology and enhancing maintenance in AN...
  28. Family Therapy in the Treatment of Adolescent Anorexia Nervosa
    WILLIAM STEWART AGRAS; Fiscal Year: 2010
    ..Additionally, there is preliminary evidence that fluoxetine may be useful in reducing comorbid psychopathology and enhancing maintenance in AN...
  29. Family Therapy in the Treatment of Adolescent Anorexia Nervosa
    DENISE ELLA WILFLEY; Fiscal Year: 2010
    ..Additionally, there is preliminary evidence that fluoxetine may be useful in reducing comorbid psychopathology and enhancing maintenance in AN...
  30. Family Therapy in the Treatment of Adolescent Anorexia Nervosa
    Harry A Brandt; Fiscal Year: 2010
    ..Additionally, there is preliminary evidence that fluoxetine may be useful in reducing comorbid psychopathology and enhancing maintenance in AN...
  31. Photoprobes for identifying potential anti-depressant and anti-anxiety medication
    DAVID JOHN LAPINSKY; Fiscal Year: 2013
    ..The objective of this application is to develop and utilize photoaffinity probes based on citalopram and fluoxetine, clinically significant compounds for treating depression and other mental illnesses, to map their corresponding ..
  32. Fluoxetine: Sensitive Ages and Genotypes for Adverse Effects in Juvenile Monkeys
    Mari S Golub; Fiscal Year: 2013
    ..test the hypothesis that the serotonin reuptake inhibitor fluoxetine influences activity and affective behavior during dosing at the juvenile stage of brain development...
  33. Role of sFRP3-Dependent Regulation of Adult Neurogenesis in Antidepressant Action
    Mi Hyeon Jang; Fiscal Year: 2013
    ..One of the most commonly prescribed treatments of major depression, fluoxetine, a selective serotonin reuptake inhibitor, is known to enhance adult neurogenesis in the dentate gyrus of the ..
  34. Characterization and Sequential Pharmacotherapy of Severe Mood Dysregulation
    JAMES JOHN MCGOUGH; Fiscal Year: 2013
    ..Once the dose is established, participants will be randomized to an additional 8 weeks with double-blind fluoxetine, a selective serotonin reuptake inhibitor used for treatment of depression and anxiety, versus placebo taken in ..
  35. Function of the Medial Habenula in Models of Anxiety and Depression
    Yun Wei A Hsu; Fiscal Year: 2013
    ..Evidence suggests that serotonin (5HT) neurons play a role in depression and anxiety, and SSRIs such as fluoxetine and other medications that target the 5HT system are available...
  36. REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTS
    Irwin Lucki; Fiscal Year: 2013
    ..We have identified a mouse strain (MRL/MpJ) that shows larger increases in neurogenesis following chronic fluoxetine. Also, the addition of stress hormones augments the effects of fluoxetine on neurogenesis in a non-responder ..
  37. Phagocytosis of dying cells, adult neurogenesis and depression
    Kodi S Ravichandran; Fiscal Year: 2013
    ..Reduced adult neurogenesis is commonly associated with mental depression. Anti-depressant drugs such as fluoxetine (Prozac) mediate their beneficial effects, in part, through maintenance of adult neurogenesis...
  38. Organismal, Cellular, and Genetic Networks in Anxiety and Depression
    Tim Wiltshire; Fiscal Year: 2012
    ..In addition, a drug fluoxetine, will be administered to mice to modulate basal level phenotypic measurements to track perturbations at the ..
  39. REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTS
    Irwin Lucki; Fiscal Year: 2009
    ..We have identified a mouse strain (MRL/MpJ) that shows larger increases in neurogenesis following chronic fluoxetine. Also, the addition of stress hormones augments the effects of fluoxetine on neurogenesis in a nonresponder ..
  40. Structural and Mechanistic Characterization of Neurotransmitter Reuptake Inhibiti
    DANENG WANG; Fiscal Year: 2012
    ..proteins can be inhibited by various drugs and therefore are the primary targets for: antidepressants such as fluoxetine (Prozac), sertraline (Zoloft), methylphenidate (Ritalin) -a prescription drug commonly used to treat attention-..
  41. Neural stem cells in the aging brain
    GRIGORI N ENIKOLOPOV; Fiscal Year: 2013
    ..cascade and in the fate of stem cells in response to antidepressant treatments of different modalities (fluoxetine, electroconvulsive shock and exercise) and to injury that induces depressive behavior (ablation of dopaminergic ..
  42. Treating Suicidal Behavior and Self-Mutilation in BPD
    Barbara Stanley; Fiscal Year: 2012
    ..This project is a continuation of a randomized clinical trial of fluoxetine and Dialectical Behavior Therapy (DBT) for the treatment of suicidal behavior and non-suicidal self injury (NSSI)..
  43. Brain Mechanisms Underlying the Congenital Predisposition to Helplessness
    Francisco Gonzalez Lima; Fiscal Year: 2010
    ..The third aim is to map the effects of the antidepressant fluoxetine on the brains of congenitally helpless rats...
  44. The Serotonin Transporter in Pulmonary Arterial Hypertension
    Kelly Chin; Fiscal Year: 2013
    ..a randomized double-blind placebo controlled trial evaluating whether blockade of the serotonin transporter with fluoxetine, a selective serotonin reuptake inhibitor, will reduce pulmonary vascular resistance in patients with PAH...
  45. SSRI-neuroprotection for HIV/drug abuse
    Norman J Haughey; Fiscal Year: 2012
    ..human use and found that two compounds within the class of the selective serotinergic release inhibitors (SSRI), fluoxetine and paroxetine, have potent neuroprotective effects against the combined effects of drugs of abuse and HIV ..
  46. Methylphenidate, Serotonin and Dopamine Interactions
    Sara R Jones; Fiscal Year: 2013
    ..We have found that the behavioral and neurochemical responses to fluoxetine are qualitatively transformed...
  47. The contributions of motor learning and inhibitory balance to stroke recovery
    Steven R Zeiler; Fiscal Year: 2013
    ..period by describing how the timing and dose of motor retraining interact to affect motor recovery, how fluoxetine (a commonly used anti-depressant medicine) can modify the sensitive period, and how specific neuronal activity ..
  48. Automated Interactive Text Messaging to Assess Adolescent Depression
    JAMES C contact MUNDT; Fiscal Year: 2010
    ..with major depression will be recruited from the NIH-sponsored "Pediatric MDD: Sequential Treatment with Fluoxetine and Relapse Prevention CBT" (MH039188;Dr. Graham Emslie, PI)...
  49. ENVIRONMENTAL AND PHARMACOLOGICAL CONTROL OF DRUG ABUSE
    Marilyn Carroll; Fiscal Year: 2000
    ..be given pharmacological treatments throughout, such as buprenorphine,an opiate mixed agonist-antagonist, and fluoxetine, serotonin reuptake blocker, which have some efficacy in reducing cocaine self- administration in animals and ..
  50. Necessity of Neurogenesis for Antidepressant Efficacy
    TARIQUE DHYAN PERERA; Fiscal Year: 2013
    ..We have also obtained preliminary evidence that fluoxetine stimulates hippocampal neurogenesis and prevents depressive behavior and that both effects are abolished by ..
  51. Depression: Synaptic mediation in sleep deprivation
    Pingfu Feng; Fiscal Year: 2013
    ..Aim 2 will compare the alterations of SAPs in a rat model of depression among treatments with SD, orexins and fluoxetine. We will first compare the short-term effects of SD by gentle handling to that of SD by orexin and the acute ..
  52. Comparative Effectiveness Research Diffusion and Mental Health Care Disparities
    BENJAMIN LE COOK; Fiscal Year: 2013
    ..g., fluoxetine use and metabolic screening for antipsychotic users);and b) psychotropic drug use that is potentially harmful (e...
  53. Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression
    J Todd Arnedt; Fiscal Year: 2012
    ..Our data further suggest that non-responders to fluoxetine treatment have shorter REM latency and more REM sleep than non-responders, particularly in the last few hours of ..
  54. Selective neuronal silencing to study hippocampal neurogenesis in depression
    Joanna L Jankowsky; Fiscal Year: 2013
    ..Our strategy will allow us to examine the function of adult-born neurons without destroying them, with the goal of more precisely defining the relationship between neurogenesis, depression, and therapeutic recovery. ..
  55. MECHANISMS OF ACTIVE NEUROTRANSMITTER TRANSPORT
    Shimon Schuldiner; Fiscal Year: 2013
    ..Hence the study of the mode of action of the neurotransporters, as proposed in this research project, is fundamental for understanding the communication between nerve cells in the normal and diseased brain. ..
  56. 2/2-Prevention of Relapse &Recurrence of Bipolar Depression
    John M Zajecka; Fiscal Year: 2013
    ..In this proposal, we will ask: "Does continuation therapy with combined lithium plus fluoxetine result in fewer MDE relapses and recurrences vs...
  57. Pediatric MDD: Sequential Treatment with Fluoxetine and Relapse Prevention CBT
    Beth D Kennard; Fiscal Year: 2012
    ..demonstrating 1) continuity of the pathophysiology of depression in the pediatric age group, 2) efficacy of fluoxetine over placebo in pediatric depression, and most recently, 3) continued use of fluoxetine beyond acute treatment ..
  58. TDM & Drug Interactions in HIVinfected Substance Abusers
    Gene Morse; Fiscal Year: 2007
    ..and commonly prescribed medications including methadone, ethinyl estradiol, fluconazole, pravastatin, and fluoxetine in HIV-infected, substance abusers The proposed methodology employs a Therapeutic Drug Monitoring (TDM) program ..
  59. Time Course and Potentiation of Fluoxetin Action
    George Battaglia; Fiscal Year: 2004
    ..The introduction of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac) has revolutionized psychiatry...
  60. SEROTONIN Treatment of Cocaine Dependence
    ERIC STRAIN; Fiscal Year: 2005
    ..Since this renewal shifts focus from tryptophan to another medication that alters serotonin functioning (fluoxetine), it has been re-titled "Serotonin Treatment of Cocaine Dependence...
  61. Galanin and GaIR2 receptors in antidepressant treatments
    Tamas Bartfai; Fiscal Year: 2005
    ..that galanin is 1 of the 8 transcripts that are significantly elevated by at least 2 antidepressant treatments, fluoxetine and electroconvulsive therapy, in the rat DRN...
  62. Galanin and GalR2 Receptors in Antidepressant Treatments
    Tamas Bartfai; Fiscal Year: 2009
    ..galanin is one of the 8 transcripts that are significantly elevated by at least two antidepressant treatments, fluoxetine and electroconvulsive therapy, in the rat DRN...
  63. FLUOXETINES EFFECT ON ANXIETY AND BREATHING IN CHILDREN
    Daniel Pine; Fiscal Year: 2000
    ..Pilot data from open studies suggest that fluoxetine holds promise as a treatment for childhood social phobia, separation anziety, and generalized anxiety disorders...
  64. MOOD EFFECT OF TESTOSTERONE VS FLUOXETINE IN HIV ILLNESS
    Judith Rabkin; Fiscal Year: 2000
    ..continuation application, the primary goal is to evaluate the antidepressant effects of testosterone compared to fluoxetine in a double-blind randomized placebo controlled clinical trial for HIV-positive patients with major depression ..
  65. SEROTONIN AND IMPULSIVE AGGRESSION--TREATMENT CORRELATES
    EMIL COCCARO; Fiscal Year: 2000
    ..period, the applicant conducted an experimental clinical trial in which the selective 5-HT uptake inhibitor, Fluoxetine, was found to significantly reduce the frequency and severity of impulsive aggressive behaviors in a 12-week ..
  66. EFFECT OF SRIs ON GONADAL STEROIDS
    Margaret Altemus; Fiscal Year: 2006
    ..determine whether this effect is a specific characteristic of SRIs, the effect of chronic treatment with an SRI, fluoxetine, on the gonadal steroid precursor hormone 17a-OH pregnenolone will be compared to the effect of a non-SRI, ..