Genomes and Genes
Summary: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
Publications351 found, 100 shown here
- Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depressionDenis J David
Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
Neuron 62:479-93. 2009..In corticosterone-treated mice where hippocampal neurogenesis is abolished by X-irradiation, the efficacy of fluoxetine is blocked in some, but not all, behavioral paradigms, suggesting both neurogenesis-dependent and -independent ..
- Requirement of hippocampal neurogenesis for the behavioral effects of antidepressantsLuca Santarelli
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Science 301:805-9. 2003..Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor...
- The antidepressant fluoxetine restores plasticity in the adult visual cortexJosé Fernando Maya Vetencourt
Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
Science 320:385-8. 2008We investigated whether fluoxetine, a widely prescribed medication for treatment of depression, restores neuronal plasticity in the adult visual system of the rat...
- Fear erasure in mice requires synergy between antidepressant drugs and extinction trainingNina N Karpova
Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
Science 334:1731-4. 2011..Combining extinction training with chronic fluoxetine, but neither treatment alone, induced an enduring loss of conditioned fear memory in adult animals...
- Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cellsDexiang Liu
Institute of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong, PR China
Neuropharmacology 61:592-9. 2011..In the present study, using BV2 microglial cell line and primary microglial culture, we investigated if fluoxetine, the most widely used antidepressant, can inhibit microglia activation...
- miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressantsAnne Baudry
Cellules Souches, Signalisation et Prions, INSERM U747, Universite Paris Descartes, 75006 Paris, France
Science 329:1537-41. 2010..In mice, chronic treatment with the SSRI fluoxetine (Prozac) increases miR-16 levels in serotonergic raphe nuclei, which reduces SERT expression...
- Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood-spinal cord barrier after spinal cord injuryJee Y Lee
Age Related and Brain Diseases Research Centre, School of Medicine, Kyung Hee University, Seoul 130 701, Korea
Brain 135:2375-89. 2012..Recent evidence indicates that fluoxetine, an anti-depressant drug, is shown to have neuroprotective effects in ischaemic brain injury, but the precise ..
- Fluoxetine targets early progenitor cells in the adult brainJuan M Encinas
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 103:8233-8. 2006..We use this line to demonstrate that the selective serotonin reuptake inhibitor antidepressant fluoxetine does not affect division of stem-like cells in the dentate gyrus but increases symmetric divisions of an early ..
- Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trialFrancois Chollet
Neurology Department, Centre Hospitalier Universitaire de Toulouse, Hopital Purpan, Toulouse, France
Lancet Neurol 10:123-30. 2011..Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that fluoxetine enhances motor recovery but its clinical efficacy is unknown...
- High-speed imaging reveals neurophysiological links to behavior in an animal model of depressionRaag D Airan
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
Science 317:819-23. 2007..Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms...
- Chronic fluoxetine selectively upregulates dopamine D₁-like receptors in the hippocampusKatsunori Kobayashi
Department of Pharmacology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
Neuropsychopharmacology 37:1500-8. 2012..We have recently demonstrated that the SSRI fluoxetine can reverse the state of maturation of the adult dentate granule cells and enhances serotonin 5-HT₄ receptor-..
- Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescenceIne Rayen
Department of Neuroscience, School of Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
PLoS ONE 6:e24003. 2011..Therefore, the aim of this study was to determine the role of exposure to fluoxetine during development on affective-like behaviors and hippocampal neurogenesis in adolescent offspring in a rodent ..
- Early-life blockade of the 5-HT transporter alters emotional behavior in adult miceMark S Ansorge
Sackler Institute for Developmental Psychobiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Science 306:879-81. 2004..Transient inhibition of 5-HTT during early development with fluoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice...
- Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspringJocelien D A Olivier
Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21 route 126, 6525, EZ, Nijmegen, The Netherlands
Psychopharmacology (Berl) 217:419-32. 2011b>Fluoxetine (Prozac®) is the most frequently prescribed drug to battle depression in pregnant women, but its safety in the unborn child has not yet been established...
- Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administrationQuentin Rainer
Equipe d Accueil 3544, Laboratoire de Neuropharmacologie, Universite Paris XI, Chatenay Malabry, France
Mol Pharmacol 81:106-12. 2012..Here we assessed the effects of sustained administration of the SSRI fluoxetine on 5-HT(1A) autoreceptor sensitivity in mice administered with corticosterone...
- The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A reviewJ D A Olivier
Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Dept of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 GA Nijmegen, The Netherlands
Prog Neuropsychopharmacol Biol Psychiatry 35:1400-8. 2011The selective serotonin reuptake inhibitor (SSRI) Prozac® (fluoxetine) is widely prescribed for the treatment of depression and anxiety-related disorders...
- Fluoxetine induced suicidal erythrocyte deathKashif Jilani
Department of Physiology, University of Tuebingen, Gmelinstr 5, Tuebingen 72076, Germany
Toxins (Basel) 5:1230-43. 2013The antidepressant fluoxetine inhibits ceramide producing acid sphingomyelinase...
- Reversal of hippocampal neuronal maturation by serotonergic antidepressantsKatsunori Kobayashi
Department of Pharmacology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Proc Natl Acad Sci U S A 107:8434-9. 2010..Here we show a distinct unique action of the serotonergic antidepressant fluoxetine in transforming the phenotype of mature dentate granule cells...
- Effects of chronic fluoxetine in animal models of anxiety and depressionStephanie C Dulawa
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Neuropsychopharmacology 29:1321-30. 2004..mouse strains for their behavioral response to chronic treatment with the selective-serotonin reuptake inhibitor fluoxetine (0, 5, 10 mg/kg/day in drinking water), which is used for the treatment of mood and anxiety disorders...
- Fluoxetine-induced cortical adult neurogenesisKoji Ohira
Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
Neuropsychopharmacology 38:909-20. 2013..Here, we show that chronic treatment with an SSRI, fluoxetine (FLX), stimulated the neurogenesis of γ-aminobutyric acid (GABA)ergic interneurons from L1-INP cells in the ..
- Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in miceS H Christiansen
Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and Department of Neuroscience and Pharmacology, Rigshospitalet O 6102, University of Copenhagen, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
Behav Brain Res 216:585-91. 2011..in brains of mice subjected to chronic restraint stress (CRS) and concomitant treatment with the antidepressant fluoxetine (FLX)...
- Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cellsJing Wen Wang
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
J Neurosci 28:1374-84. 2008..Here we examined the effects of subchronic and chronic fluoxetine on the structural and physiological properties of young granule cells...
- Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndromePatrizia Bianchi
Department of Human and General Physiology, University of Bologna, I 40126 Bologna, Italy
J Neurosci 30:8769-79. 2010..Neonate Ts65Dn mice were treated from postnatal day (P) 3 to P15 with fluoxetine, an antidepressant that inhibits serotonin (5-HT) reuptake and increases proliferation in the adult Ts65Dn mouse ..
- Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult ratMasafumi Kodama
Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Biol Psychiatry 56:570-80. 2004..There has been increasing evidence that atypical antipsychotics are effective in the treatment of mood disorders or for augmenting 5-hydroxytryptamine selective reuptake inhibitors for treatment-resistant depression...
- The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodelingJ M Bessa
Life and Health Science Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
Mol Psychiatry 14:764-73, 739. 2009..In the last 2 weeks of stress exposure, animals were treated with the antidepressants fluoxetine, imipramine, CP 156,526 or SSR 1494515, alone or combined with methylazoxymethanol, a cytostatic agent used to ..
- Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trialJohn March
Duke Clinical Research Institute, Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
JAMA 292:807-20. 2004..Initial treatment of major depressive disorder in adolescents may include cognitive-behavioral therapy (CBT) or a selective serotonin reuptake inhibitor (SSRI). However, little is known about their relative or combined effectiveness...
- Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatmentJessica E Malberg
Wyeth Neuroscience, Princeton, NJ, USA
Neuropsychopharmacology 28:1562-71. 2003..Administration of fluoxetine, a serotonin selective reuptake inhibitor, from days 2-8 blocked the downregulation of cell proliferation ..
- Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depressionR Alonso
Sanofi Synthelabo Recherche, Rue du Professeur J Blayac, Montpellier, France
Mol Psychiatry 9:278-86, 224. 2004..antagonist SSR125543A, the V(1b) receptor antagonist SSR149415, and the clinically effective antidepressant fluoxetine may influence newborn cell proliferation and differentiation in the dentate gyrus of mice subjected to the ..
- Prevalence and patterns of antidepressant drug use during pregnancyTessa Ververs
Department of Clinical Pharmacy, Clinical Chemistry and Laboratory Medicine, University Medical Center UMC Utrecht, Utrecht, The Netherlands
Eur J Clin Pharmacol 62:863-70. 2006..The aim of this study was to determine the extent and patterns of antidepressant use before, during and after pregnancy in a large population in The Netherlands...
- Suicidal thoughts and behavior with antidepressant treatment: reanalysis of the randomized placebo-controlled studies of fluoxetine and venlafaxineRobert D Gibbons
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Arch Gen Psychiatry 69:580-7. 2012..The US Food and Drug Administration issued a black box warning for antidepressants and suicidal thoughts and behavior in children and young adults...
- Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviorsL Conboy
Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Mol Psychiatry 16:533-47. 2011..These findings underscore MIF as a potentially relevant molecular target for the development of treatments linked to deficits in neurogenesis, as well as to problems related to anxiety, depression, and cognition...
- Benefits from antidepressants: synthesis of 6-week patient-level outcomes from double-blind placebo-controlled randomized trials of fluoxetine and venlafaxineRobert D Gibbons
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Arch Gen Psychiatry 69:572-9. 2012..Some meta-analyses suggest that efficacy of antidepressants for major depression is overstated and limited to severe depression...
- Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatmentValentine Bouet
Groupe Mémoire et Plasticité Comportementale GMPc, Universite de Caen Basse Normandie, Caen, France
Psychopharmacology (Berl) 221:329-39. 2012Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are increasingly used for the treatment of depression in children...
- Prenatal fluoxetine exposure induces life-long serotonin 5-HT₃ receptor-dependent cortical abnormalities and anxiety-like behaviourLaura A Smit-Rigter
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, P O Box 94232, 1090 GE Amsterdam, The Netherlands
Neuropharmacology 62:865-70. 2012..Here we show that in mice, the adverse effects of the widely used antidepressant and SSRI fluoxetine are critically dependent on the 5-HT(3) receptor, the only ligand-gated ion channel in the family of serotonin ..
- Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pupsYing Chao Chang
Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Guang University College of Medicine, Kaohsiung, Taiwan
Neurobiol Dis 24:101-13. 2006..Chronic treatment of fluoxetine, a selective serotonin reuptake inhibitor, can upregulate CREB activation in the hippocampus...
- Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activationYoung C Chung
Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
Neuropharmacology 60:963-74. 2011..Here, we report that fluoxetine, one of the most commonly prescribed antidepressants, prevents MPTP-induced degeneration of nigrostriatal DA ..
- Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatmentM Fava
Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 61:863-7. 2000..Also unknown is whether different agents have differential effects. To examine these questions, we assessed weight changes in patients randomly assigned to long-term treatment with fluoxetine, sertraline, or paroxetine.
- Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatmentBoldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
Neuropsychopharmacology 31:1616-26. 2006..Additionally, we examined whether antidepressant treatment with fluoxetine, a selective serotonin reuptake inhibitor, offered protection from these stress-induced effects...
- Neonatal fluoxetine exposure affects the neuronal structure in the somatosensory cortex and somatosensory-related behaviors in adolescent ratsLi Jen Lee
Department of Anatomy, College of Medicine, National Taiwan University, No 1, Ren Ai Rd, Section 1, Taipei 100, Taiwan
Neurotox Res 15:212-23. 2009..In this study, we examined the effects of early exposure of fluoxetine, the most popular SSRI-type antidepressant, on the developing somatosensory system...
- Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytesIgor Allaman
Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, CH 1015, Switzerland
Psychopharmacology (Berl) 216:75-84. 2011..During therapeutic treatment for major depression, fluoxetine, one of the most commonly prescribed selective serotonin reuptake inhibitor (SSRI) antidepressants, accumulates ..
- Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratusJan A Mennigen
Centre for Advances Research in Environmental Genomics, Department of Biology, University of Ottawa, Ontario, Canada
Aquat Toxicol 100:354-64. 2010b>Fluoxetine (FLX) is a pharmaceutical acting as a selective serotonin reuptake inhibitor and is used to treat depression in humans...
- Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatmentC Song
Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada
Pharmacopsychiatry 42:182-8. 2009..between pro- and anti-inflammatory cytokines and between Th1 and Th2 produced cytokines in depressed patients and 2) evaluate and compare the effect of treatments with electroacupuncture (EA) and fluoxetine on these cytokines.
- Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ miceG J Huang
Mol Psychiatry 13:119-21. 2008
- Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracilMaha ElBeltagy
Department of Anatomy, Menoufiya University, Egypt
Behav Brain Res 208:112-7. 2010..reports indicate that hippocampal dependent neurogenesis and cognition are enhanced by the SSRI antidepressant Fluoxetine. In this investigation the behavioural effects of chronic (two week) treatment with 5-FU and (three weeks) with ..
- Short-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampusTibor Hajszan
Department of Obstetrics, Gynaecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, FMB 312, New Haven, CT 06520 8063, USA
Eur J Neurosci 21:1299-303. 2005..Here we provide evidence that daily administration of the antidepressant fluoxetine to ovariectomized female rats for 5 days induces a robust increase in pyramidal cell dendritic spine synapse ..
- Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrusMikko Sairanen
Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 25:1089-94. 2005..Furthermore, we observed that chronic treatment with imipramine or fluoxetine produced a temporally similar increase in both BrdU-positive and terminal deoxynucleotidyl transferase-mediated ..
- Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatmentBoldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
Neuropsychopharmacology 32:1490-503. 2007..subjected to 5 weeks of daily social defeat by an aggressive conspecific and received concomitant, daily, oral fluoxetine (10 mg/kg) during the last 4 weeks...
- Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behaviorDaniela Popa
Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S677, F 75013 Paris, France
J Neurosci 28:3546-54. 2008..Such early-life impairments might predispose individuals to sleep and/or mood disorders...
- Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetineR Ranganathan
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 21:5871-84. 2001..elegans. The selective serotonin reuptake inhibitor fluoxetine (Prozac) potentiated the enhanced slowing response, and this potentiation required mod-5 function, establishing ..
- Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortexFrank P Bymaster
Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
Psychopharmacology (Berl) 160:353-61. 2002The selective serotonin uptake inhibitor (SSRI) fluoxetine has been shown to not only increase the extracellular concentrations of serotonin, but also dopamine and norepinephrine extracellular concentrations in rat prefrontal cortex...
- Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult miceKoji Ohira
Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
Mol Brain 4:10. 2011..Since almost all of those studies treated animals with drugs for 2 to 4 weeks as chronic treatment models of antidepressants, it is possible that antidepressant treatments for longer periods would affect adult neurogenesis in the SVZ...
- Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brainSuzanne Cassel
Unité INSERM U575, Centre de Neurochimie, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France
Mol Pharmacol 70:487-92. 2006..protein MBD1, were significantly induced in normal adult rat brain after repeated injections of fluoxetine or cocaine for 10 days (one injection per day)...
- Reduced hippocampal neurogenesis and number of hilar neurones in streptozotocin-induced diabetic mice: reversion by antidepressant treatmentJuan Beauquis
Laboratory of Neuroendocrine Biochemistry, Institute of Biology and Experimental Medicine, National Research Council Argentina, Obligado 2490 1428 Buenos Aires, Argentina
Eur J Neurosci 23:1539-46. 2006..is also deficient in diabetic mice, which led us to study whether the selective serotonin reuptake inhibitor fluoxetine influences cell proliferation in streptozotocin-diabetic animals...
- Cognitive therapy versus fluoxetine in generalized social phobia: a randomized placebo-controlled trialDavid M Clark
Department of Psychology, Institute of Psychiatry, London, United Kingdom
J Consult Clin Psychol 71:1058-67. 2003..Psychiatric Association, 1994) criteria for generalized social phobia were assigned to cognitive therapy (CT), fluoxetine plus self-exposure (FLU + SE), or placebo plus self-exposure (PLA + SE)...
- Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosteroneGuo Jen Huang
Department of Anatomy and Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
Biol Psychiatry 59:619-24. 2006b>Fluoxetine stimulates proliferation of progenitor cells in the dentate gyrus of the adult hippocampus. There are suggestions that this action may underlie the therapeutic effects of such drugs in depression...
- Treatment of resistant human colon cancer xenografts by a fluoxetine-doxorubicin combination enhances therapeutic responses comparable to an aggressive bevacizumab regimenMirit Argov
Department of Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
Cancer Lett 274:118-25. 2009..purpose of this study was to characterize moderate drug resistance in human colon cancer, and it's modulation by fluoxetine. In vitro fluoxetine enhanced doxorubicin's cytotoxicity (10-fold), increased doxorubicin's intracellular ..
- Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetineKatsunori Kobayashi
Department of Pharmacology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Mol Brain 4:12. 2011..We have recently shown that the SSRI fluoxetine can reverse the state of maturation of hippocampal granule cells in adult mice...
- Behavioral and biochemical responses of hybrid striped bass during and after fluoxetine exposureKristen M Gaworecki
Institute of Environmental Toxicology, Department of Biological Sciences, Clemson University, Pendleton, SC 29670, United States
Aquat Toxicol 88:207-13. 2008..One important behavior that could be impacted is the ability to capture prey. We hypothesized that sublethal fluoxetine exposure may lead to feeding behavior abnormalities in hybrid striped bass (Morone saxatilis x M. chrysops)...
- The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphomaSuzanne M Cloonan
School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
Int J Cancer 128:1712-23. 2011..We report that the antidepressants maprotiline and fluoxetine induce autophagic PCD in the chemoresistant Burkitt's lymphoma (BL) cell line DG-75, which does not involve ..
- Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorderNayereh Khoraminya
Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Aust N Z J Psychiatry 47:271-5. 2013To compare the therapeutic effects of vitamin D3 plus fluoxetine and fluoxetine alone in patients with major depressive disorder.
- Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in miceFraser Murray
Merck Sharp and Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR United Kingdom
Eur J Pharmacol 583:115-27. 2008..We have also examined the effects of chronic administration of fluoxetine and imipramine on these parameters...
- Pharmacokinetics of selective serotonin reuptake inhibitorsC Hiemke
Department of Psychiatry, University of Mainz, Germany
Pharmacol Ther 85:11-28. 2000The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect profile...
- Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in miceDiane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Hippocampus 17:175-80. 2007..Both male and female mice had a greater number of BrdU-immunoreactive SGZ cells following chronic treatment with fluoxetine. This demonstrates a parallel proliferation response in both genders, and opens avenues for addressing the ..
- Antidepressant drugs reverse the loss of adult neural stem cells following chronic stressSeiji Hitoshi
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, Japan
J Neurosci Res 85:3574-85. 2007..persisted for weeks after the cessation of stress but was reversed by treatment with the antidepressant drugs fluoxetine and imipramine...
- A randomized, double-blind comparison of olanzapine/fluoxetine combination, olanzapine, and fluoxetine in treatment-resistant major depressive disorderMichael E Thase
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 68:224-36. 2007Two parallel, 8-week double-blind studies compared olanzapine/fluoxetine combination, olanzapine, and fluoxetine in outpatients with treatment-resistant depression (TRD).
- Stepped care and cognitive-behavioural therapy for bulimia nervosa: randomised trialJames E Mitchell
Neuropsychiatric Research Institute, 120 South 8th Street, Fargo, North Dakota 58103, USA
Br J Psychiatry 198:391-7. 2011This study compared the best available treatment for bulimia nervosa, cognitive-behavioural therapy (CBT) augmented by fluoxetine if indicated, with a stepped-care treatment approach in order to enhance treatment effectiveness.
- The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expressionMaya First
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, 49100 Petah Tikva, Israel
J Mol Neurosci 45:246-55. 2011..We evaluated the effect of CMS and the selective serotonin reuptake inhibitor, fluoxetine (FLX) treatment on behavioral and cognitive parameters in rats, and on HC and frontal cortex (FC) neurotrophic ..
- Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory receptionJ X Chen
Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Am J Physiol 275:G433-48. 1998..cell-1 . min-1), Na+-dependent mechanism that was inhibited by chlorimipramine > imipramine > fluoxetine > desipramine > zimelidine...
- BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticityKevin G Bath
Department of Psychiatry, Weill Medical College of Cornell, New York, NY 10021, USA
Neuropsychopharmacology 37:1297-304. 2012..anxiety-like behaviors that are not rescued with the prototypic selective serotonin reuptake inhibitor (SSRI), fluoxetine. A prominent hypothesis is that SSRI-induced augmentation of BDNF protein expression and the beneficial trophic ..
- Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropionCristiano R Jesse
Laboratorio de Sintese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, CEP 97105 900, Santa Maria, RS, Brazil
Psychopharmacology (Berl) 212:513-22. 2010..Pain co-morbidity symptoms are rarely assessed in animal models of neuropathic pain. Neuropathic pain is characterized by hyperexcitability within nociceptive pathways and remains difficult to treat with standard analgesics...
- Uptake and depuration of the anti-depressant fluoxetine by the Japanese medaka (Oryzias latipes)Gordon Paterson
Worsfold Water Quality Centre, Trent University, Peterborough, Ontario, Canada
Chemosphere 74:125-30. 2008..In this study, Japanese medaka (Oryzias latipes) were exposed to fluoxetine at a nominal concentration of 0...
- Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired miceEleni Paizanis
INSERM UMR S677, F 75013 Paris, France
Int J Neuropsychopharmacol 13:759-74. 2010..agonist/5-HT(2C) receptor antagonist, agomelatine, compared to the selective 5-HT reuptake inhibitor (SSRI), fluoxetine, on hippocampal neurogenesis, GR and BDNF expression and antidepressant-responsive behaviour (tail suspension ..
- Pharmaceuticals as neuroendocrine disruptors: lessons learned from fish on ProzacJan A Mennigen
Centre for Advanced Research in Environmental Genomics and Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
J Toxicol Environ Health B Crit Rev 14:387-412. 2011..One of the most prevalent environmental pharmaceuticals in North America and Europe is the antidepressant fluoxetine, a selective serotonin reuptake inhibitor (SSRI) and the active ingredient of Prozac...
- Anti-inflammatory properties of desipramine and fluoxetineCaroline Roumestan
INSERM, U454, Montpellier, France
Respir Res 8:35. 2007..We also analysed whether antidepressants act directly on peripheral cell types that participate in the inflammatory response in these diseases...
- Effects of chronic fluoxetine treatment on the rat somatosensory cortex: activation and induction of neuronal structural plasticityR Guirado
Cell Biology Department, Neurobiology Unit and Program in Basic and Applied Neurosciences, Universitat de Valencia, Spain
Neurosci Lett 457:12-5. 2009..In a previous report we found that chronic fluoxetine treatment increases the expression of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), a ..
- Are all antidepressants really the same? The case of fluoxetine: a systematic reviewAndrea Cipriani
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
J Clin Psychiatry 67:850-64. 2006To systematically review the efficacy and tolerability of fluoxetine, the most widely studied of newer antidepressants, in comparison with all other antidepressants in the acute treatment of depression in patients aged more than 18 years.
- Fluoxetine (Prozac) interaction with the mitochondrial voltage-dependent anion channel and protection against apoptotic cell deathEdna Nahon
Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
FEBS Lett 579:5105-10. 2005b>Fluoxetine (Prozac) is a potent antidepressant compound inhibiting serotonin reuptake, but also Na+, K+ and Ca2+ channels and reported to both trigger and prevent apoptosis...
- Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effectsA Bortolozzi
Department of Neurochemistry and Neuropharmacology, IIBB CSIC IDIBAPS, Barcelona, Spain
Mol Psychiatry 17:612-23. 2012..Moreover, i.c.v. C-1A-siRNA infusion augmented the increase in extracellular serotonin evoked by fluoxetine in prefrontal cortex to the level seen in 5-HT(1A)R knockout mice...
- Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in ratsMurray R Thompson
School of Psychology, University of Sydney, NSW, Australia
Neuropsychopharmacology 29:694-704. 2004..The present study examined whether chronic treatment with the antidepressant drug fluoxetine could reverse such effects...
- Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspringJ L Pawluski
School for Mental Health and Neuroscience, Department of Neuroscience, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
Neuroscience 220:131-41. 2012..Therefore, the aim of the present study was to determine how maternal fluoxetine treatment affects the developing HPA system of adolescent male and female offspring using a model of maternal ..
- Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, β-catenin and antidepressant-like effectsF Pilar-Cuéllar
Departamento de Fisiologia y Farmacologia, Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, Universidad de Cantabria CSIC IDICAN, Santander, Cantabria, Spain
Br J Pharmacol 165:1046-57. 2012..Here, we have studied the involvement of neuroplasticity pathways and/or the 5-hydroxytryptaminergic system in the antidepressant-like effect of this combined treatment, given subchronically...
- Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramineZaorui Zhao
Graduate Program in Pharmaceutical and Pharmacological Sciences, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
Neuropsychopharmacology 33:3190-200. 2008..Understanding the mechanisms underlying NET regulation in vivo may suggest novel targets for therapeutic intervention in the treatment of depression...
- Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depressionMauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Arch Gen Psychiatry 60:1079-88. 2003....
- Fluoxetine treatment of alcoholic perpetrators of domestic violence: a 12-week, double-blind, randomized, placebo-controlled intervention studyDavid T George
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bldg 10, Clinical Research Center, 10 Center Drive, Bethesda, MD 20892 1540, USA
J Clin Psychiatry 72:60-5. 2011..This score served as a surrogate marker for the anger and physical aggression that characterize perpetrators of IPV...
- Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortexE Ampuero
Laboratorio de Neurociencias, Universidad de Los Andes, Santiago, Chile
Neuroscience 169:98-108. 2010..To gain further insight into these changes in the cerebral cortex, rats were treated with fluoxetine (flx) for 4 weeks. These animals showed decreased anxiety and learned helplessness...
- Comparison of the effects of fluoxetine, imipramine and placebo on personality in atypical depressionVito Agosti
New York State Psychiatric Institute, Unit 35, 1051 Riverside Drive, New York, NY 10032, USA
J Affect Disord 71:113-20. 2002..Studies have confirmed the efficacy of a several antidepressants in the treatment of atypical depression. Whether their pathological dimensions of personality diminish after benefitting from effective medication treatment is unclear...
- Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout miceMartin Egeland
Center for Molecular Medicine, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
Biol Psychiatry 67:1048-56. 2010..Because chronic treatment with antidepressants also upregulates p11, we hypothesized that p11 might regulate effects of antidepressants on aspects of neurogenesis...
- Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptorKerri A Holick
Department of Pharmacology, Columbia University, New York, NY 10032, USA
Neuropsychopharmacology 33:406-17. 2008..reported that chronic, but not subchronic, treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine altered behavior in the forced swimming test (FST) in BALB/cJ mice...
- Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in ratsHenry A Nasrallah
Dept of Psychiatry, Univ of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
Brain Res 1354:23-9. 2010..Young adult male rats were treated with risperidone and paliperidone, atypical antipsychotic medications; fluoxetine, a selective serotonin reuptake inhibitor (SSRI) antidepressant; and diluent control for 28days via drinking ..
- Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroidsGraziano Pinna
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 101:6222-5. 2004..In these mice, the PTB-induced loss of righting reflex is greatly reduced. Fluoxetine (FLX) and norfluoxetine (NFLX) stereospecifically reverse the effect of social isolation on the PTB-induced loss ..
- Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in ratsFeng Guo Zhai
Department of Clinical Pharmacology, China Medical University, Shenyang, China
Clin Exp Pharmacol Physiol 36:850-6. 2009..5 channels and apoptosis in the protective effect of the SSRI fluoxetine against PAH. 2. Monocrotaline (MCT) was used to establish PAH in Wistar rats...
- Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in ratsShao Ping Zhu
Department of Cardiothoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China
Clin Exp Pharmacol Physiol 36:e1-5. 2009..Thus, the aim of the present study was to investigate the short- and long-term effects of fluoxetine on monocrotaline (MCT)-induced PAH and associated pathophysiological changes in PAH models. 2...
- Effects of olanzapine alone and olanzapine/fluoxetine combination on health-related quality of life in patients with bipolar depression: secondary analyses of a double-blind, placebo-controlled, randomized clinical trialLizheng Shi
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Clin Ther 26:125-34. 2004..Improving patients' health-related quality of life (HRQOL) could be a treatment goal for bipolar depression...
- Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentographyD P Uzunov
Department of Psychiatry, University of Illinois at Chicago 60612, USA
Proc Natl Acad Sci U S A 93:12599-604. 1996b>Fluoxetine administered intraperitoneally to sham-operated or adrenalectomized/castrated (ADX/CX) male rats dose-dependently (2.9-58 mumol/kg i.p...
- Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrusNicola D Hanson
Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Pharmacol Exp Ther 337:180-6. 2011..We found no effect of the selective serotonin reuptake inhibitor fluoxetine or the corticotropin-releasing factor receptor 1 antagonist R121919 [3-[6-(dimethylamino)-4-methylpyridin-3-yl]-..
- Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar ratsA B Marcussen
Department of Pharmacology Target Research, H Lundbeck A S, Valby, Denmark
Acta Neurol Scand 117:94-100. 2008....
- Approximate entropy of symptoms of mood: an effective technique to quantify regularity of moodVikram K Yeragani
Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA
Bipolar Disord 5:279-86. 2003..In this study, we investigated regularity of mood using APEN (Approximate Entropy) on daily subjective ratings using a Visual Analog Scale with 11 items pertaining to mood...
- Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapyLaura Lyons
School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, UK
Psychopharmacology (Berl) 215:105-15. 2011..It is postulated that these impairments are due to these drugs targeting neural precursors within the adult hippocampus, the loss of which has been associated with memory impairment...
- Memory impairment in patients with late-onset major depression: the effect of antidepressant therapyRoberto Gallassi
Centre for the Neurological Study of Cerebral Aging, Department of Neurological Sciences, University of Bologna, Italy
J Affect Disord 91:243-50. 2006..Cognitive deficits have been described in patients with major depression (MD), although many aspects remain unsettled...
- Paradoxical anxiogenic response of juvenile mice to fluoxetineJi Eun Oh
Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
Neuropsychopharmacology 34:2197-207. 2009..b>Fluoxetine (Prozac) is the first approved SSRI for the treatment of depression in this population...
- Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat damsJosephine M Johns
Department of Psychiatry, The University of North Carolina at Chapel Hill, 424 Taylor Hall, CB 7096, Chapel Hill, NC 27599 7096, USA
Int J Dev Neurosci 22:321-8. 2004..were determined for lactating rat dams on postpartum day 6 (PPD 6) that were gestationally treated with cocaine, fluoxetine, saline or an amfonelic acid/fluoxetine drug combination...
- Remodeling Neuronal Chromatin in Mouse Models for DepressionSchahram Akbarian; Fiscal Year: 2013..exhibit antidepressant-like effects, or enhance the therapeutic effect of a conventional antidepressant such as fluoxetine. Based on these findings, it is assumed that drug induced hyperacetylation of histones and the resulting ..
- Serotonin Receptor Modulation of Neurotrophic Factors in the RetinaMark E Pennesi; Fiscal Year: 2013..SSRIs, such as fluoxetine or paroxetine, have been widely and safely used to treat a number of psychiatric diseases such as depression and ..
- Memory and Mood Enhancing Therapies for Gulf War IllnessAshok K Shetty; Fiscal Year: 2013..Indeed, our preliminary studies suggest that administration of antidepressants such as fluoxetine (FLU) or rolipram (ROL) after a combined exposure to chemicals (PB+DEET+Permethrin) and stress has promise for ..
- Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood DepressionMary A Fristad; Fiscal Year: 2013..A recent meta-analysis found fluoxetine to be the only antidepressant medication with significant empirical support for decreasing depression in ..
- The Role of HIF-1 in Neurogenic and Behavior Responses to Antidepressants.W TIMOTHY O'BRIEN; Fiscal Year: 2013..signaling, is required for the effects of lithium and the antidepressants, imipramine and fluoxetine on behavior...
- GABA-active neurosteroids in contextual fear responsesGraziano Pinna; Fiscal Year: 2011..excessive contextual fear responses can be normalized by administering neurosteroidogenic drugs, including fluoxetine (FLX) (PNAS 105, 5567-5572. 2008) at doses too low to inhibit serotonin reuptake (Curr Opin Pharmacol 9, 24- 30...
- Behavioral and Molecular Effects of Antenatal SSRI ExposureLawrence S Quang; Fiscal Year: 2013..The proposed experiments will entail antenatal exposure of pregnant ePet-EYFP mice with the SSRI, fluoxetine. Subsequently, phenotypes of offspring will be examined using behavioral assays and molecular techniques...
- Serotonergic Contribution to Adolescent Risk TakingANDREW EMMETT ARRANT; Fiscal Year: 2012..to the anxiogenic effects of the serotonin releaser fenfluramine (2 mg/kg) and the serotonin reuptake inhibitor fluoxetine (10 mg/kg) in the light/dark (LD) test...
- Bupropion for Depression in ESRD Patients on HemodialysisPedro L Delgado; Fiscal Year: 2013..treatment of MDD in ESRD/HD patients have mostly used the selective serotonin reuptake inhibitor (SSRI) fluoxetine and there is some evidence of efficacy...
- Epigenetic modulation of antidepressant efficacyClaudia Schmauss; Fiscal Year: 2013..Strikingly, adolescent fluoxetine treatment of ELS Balb/c mice exerted powerful antidepressant effects and further elevated levels of acetylated ..
- 1/3-Reducing Suicial Ideation Through Insomnia Treatment (REST-IT)WILLIAM VAUGHN MCCALL; Fiscal Year: 2013..We have unpublished, preliminary data showing that the addition of the hypnotic eszopiclone to open-label fluoxetine in the treatment of depressed insomniacs is associated with a reduction in suicidal ideation, as compared with ..
- Use of a mouse model of anxious depression to assess the safety of pediatric antiBernhard Luscher; Fiscal Year: 2010..In particular, treatment of children and adolescents with antidepressant drugs such as fluoxetine may result in increased suicidal behavior and lethality...
- Mechanisms of Drug Induced PhospholipidosisJAMES ALAN SHAYMAN; Fiscal Year: 2013..Specific examples of agents that cause phospholipidosis include, but are not limited to, azithromycin, fluoxetine, amiodarone, chloroquine, imipramine, and ketoconazole...
- Processing of emotional content and brain activation in adolescents treated withGIOVANNI TIRADO SANTIAGO; Fiscal Year: 2010..a R15 that seeks to examine the relationship between a) the efficacy of cognitive behavioral therapy (CBT) and fluoxetine treatment in adolescents with a positive diagnosis for major depressive disorder (MDD), and b) brain structure ..
- Medications and the Risk of Sudden Cardiac DeathWayne A Ray; Fiscal Year: 2013..studies and case reports of torsade de pointes suggest four specific widely used antidepressants--fluoxetine, citalopram, escitalopram, and trazodone--may increase risk of sudden cardiac death...
- Mechanisms Underlying Treatment-Resistant Depression and Anxiety in Mouse ModelsBenjamin A Samuels; Fiscal Year: 2013..we will fully examine the role of TGFbeta signaling in the dentate gyrus in mediating the effects of fluoxetine, and ask if activation of TGFbeta signaling is capable of converting non-responders to treatment into responders...
- CRCNS: Computational Model for Neural Stem Cell Divisions in the Adult BrainAlexei Koulakov; Fiscal Year: 2013..For instance, an antidepressant drug fluoxetine (Prozac) enhances, whereas aging decreases, hippocampal neurogenesis...
- In vitro and in vivo study of simvastatin plus lithium in bipolar depressionRoy H Perlis; Fiscal Year: 2013..A recent rodent study found evidence that a statin augmented the antidepressant-like effects with fluoxetine. Intriguingly, multiple population-based studies also suggest that statins may be associated with a ..
- PSYCHOSTIMULANT RECOGNITION BY SEROTONIN TRANSPORTERSEric L Barker; Fiscal Year: 2010..most antidepressant drugs as well as many drugs of abuse. Antidepressants such as paroxetine, fluoxetine, and imipramine bind to the transporter and inhibit serotonin uptake, thereby prolonging the extracellular ..
- Serotonin and the Modulation of Brain DevelopmentJay A Gingrich; Fiscal Year: 2012..of genetically-impaired SERT mice are recapitulated by early life exposure to SERT-blocking agents such as fluoxetine, clomipramine, and citalopram...
- Muscle function and depression-like behavior in a mouse model of cancer fatigueLOREN EUGENE WOLD; Fiscal Year: 2013..expression;ibuprofen to reduce the activity of a downstream mediator of TNFa-induced skeletal muscle wasting;fluoxetine, a selective serotonin reuptake inhibitor (SSRI) , or 1-methyl tryptophan, a competitive antagonist of ..
- Functional characterization of SSRI resistant genes using C. elegansJI Y SZE; Fiscal Year: 2010..This proposal is based on our preliminary data indicating that the SSRI fluoxetine (Prozac ) targets serotonin postsynaptic targets to regulate the activity of acetylcholine, GABA, and glutamate ..
- Serotonin Reuptake Inhibitors and 5-HT1A ReceptorsGeorge Battaglia; Fiscal Year: 2009..In neuroendocrine neurons in the adult hypothalamus, fluoxetine (Prozac(R)) and other serotonin-selective reuptake inhibitors (SSRIs) desensitize 5-HT1A activation of plasma ..
- OCT Blockade to Restore Sociability in 5-HT Transporter Knock-Out MiceGeorgianna G Gould; Fiscal Year: 2012..Drug interventions for these disorders, such as risperidone (Risperdal) and fluoxetine (Prozac), commonly enhance 5-HT neurotransmission or mimic its downstream effects, but these interventions often ..
- 1/2-Prevention of Relapse &Recurrence of Bipolar DepressionRobert J Derubeis; Fiscal Year: 2013..In this application, we will ask: "Does continuation therapy with combined lithium plus fluoxetine result in fewer MDE relapses and recurrences vs...
- Development of rat models of the effort-related symptoms of depressionJohn D Salamone; Fiscal Year: 2013..of a novel treatment strategy for depression (adenosine A2A antagonists) and two well known drugs (bupropion and fluoxetine), using behavioral models of effort-related function...
- Family Therapy in the Treatment of Adolescent Anorexia NervosaD Blake Woodside; Fiscal Year: 2010..Additionally, there is preliminary evidence that fluoxetine may be useful in reducing comorbid psychopathology and enhancing maintenance in AN...
- Family Therapy in the Treatment of Adolescent Anorexia NervosaWILLIAM STEWART AGRAS; Fiscal Year: 2010..Additionally, there is preliminary evidence that fluoxetine may be useful in reducing comorbid psychopathology and enhancing maintenance in AN...
- Family Therapy in the Treatment of Adolescent Anorexia NervosaDENISE ELLA WILFLEY; Fiscal Year: 2010..Additionally, there is preliminary evidence that fluoxetine may be useful in reducing comorbid psychopathology and enhancing maintenance in AN...
- Family Therapy in the Treatment of Adolescent Anorexia NervosaHarry A Brandt; Fiscal Year: 2010
- Photoprobes for identifying potential anti-depressant and anti-anxiety medicationDAVID JOHN LAPINSKY; Fiscal Year: 2013..The objective of this application is to develop and utilize photoaffinity probes based on citalopram and fluoxetine, clinically significant compounds for treating depression and other mental illnesses, to map their corresponding ..
- Fluoxetine: Sensitive Ages and Genotypes for Adverse Effects in Juvenile MonkeysMari S Golub; Fiscal Year: 2013..test the hypothesis that the serotonin reuptake inhibitor fluoxetine influences activity and affective behavior during dosing at the juvenile stage of brain development...
- Role of sFRP3-Dependent Regulation of Adult Neurogenesis in Antidepressant ActionMi Hyeon Jang; Fiscal Year: 2013..One of the most commonly prescribed treatments of major depression, fluoxetine, a selective serotonin reuptake inhibitor, is known to enhance adult neurogenesis in the dentate gyrus of the ..
- Characterization and Sequential Pharmacotherapy of Severe Mood DysregulationJAMES JOHN MCGOUGH; Fiscal Year: 2013..Once the dose is established, participants will be randomized to an additional 8 weeks with double-blind fluoxetine, a selective serotonin reuptake inhibitor used for treatment of depression and anxiety, versus placebo taken in ..
- Function of the Medial Habenula in Models of Anxiety and DepressionYun Wei A Hsu; Fiscal Year: 2013..Evidence suggests that serotonin (5HT) neurons play a role in depression and anxiety, and SSRIs such as fluoxetine and other medications that target the 5HT system are available...
- REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTSIrwin Lucki; Fiscal Year: 2013..We have identified a mouse strain (MRL/MpJ) that shows larger increases in neurogenesis following chronic fluoxetine. Also, the addition of stress hormones augments the effects of fluoxetine on neurogenesis in a non-responder ..
- Phagocytosis of dying cells, adult neurogenesis and depressionKodi S Ravichandran; Fiscal Year: 2013..Reduced adult neurogenesis is commonly associated with mental depression. Anti-depressant drugs such as fluoxetine (Prozac) mediate their beneficial effects, in part, through maintenance of adult neurogenesis...
- Organismal, Cellular, and Genetic Networks in Anxiety and DepressionTim Wiltshire; Fiscal Year: 2012..In addition, a drug fluoxetine, will be administered to mice to modulate basal level phenotypic measurements to track perturbations at the ..
- REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTSIrwin Lucki; Fiscal Year: 2009..We have identified a mouse strain (MRL/MpJ) that shows larger increases in neurogenesis following chronic fluoxetine. Also, the addition of stress hormones augments the effects of fluoxetine on neurogenesis in a nonresponder ..
- Structural and Mechanistic Characterization of Neurotransmitter Reuptake InhibitiDANENG WANG; Fiscal Year: 2012..proteins can be inhibited by various drugs and therefore are the primary targets for: antidepressants such as fluoxetine (Prozac), sertraline (Zoloft), methylphenidate (Ritalin) -a prescription drug commonly used to treat attention-..
- Neural stem cells in the aging brainGRIGORI N ENIKOLOPOV; Fiscal Year: 2013..cascade and in the fate of stem cells in response to antidepressant treatments of different modalities (fluoxetine, electroconvulsive shock and exercise) and to injury that induces depressive behavior (ablation of dopaminergic ..
- Treating Suicidal Behavior and Self-Mutilation in BPDBarbara Stanley; Fiscal Year: 2012..This project is a continuation of a randomized clinical trial of fluoxetine and Dialectical Behavior Therapy (DBT) for the treatment of suicidal behavior and non-suicidal self injury (NSSI)..
- Brain Mechanisms Underlying the Congenital Predisposition to HelplessnessFrancisco Gonzalez Lima; Fiscal Year: 2010..The third aim is to map the effects of the antidepressant fluoxetine on the brains of congenitally helpless rats...
- The Serotonin Transporter in Pulmonary Arterial HypertensionKelly Chin; Fiscal Year: 2013..a randomized double-blind placebo controlled trial evaluating whether blockade of the serotonin transporter with fluoxetine, a selective serotonin reuptake inhibitor, will reduce pulmonary vascular resistance in patients with PAH...
- SSRI-neuroprotection for HIV/drug abuseNorman J Haughey; Fiscal Year: 2012..human use and found that two compounds within the class of the selective serotinergic release inhibitors (SSRI), fluoxetine and paroxetine, have potent neuroprotective effects against the combined effects of drugs of abuse and HIV ..
- Methylphenidate, Serotonin and Dopamine InteractionsSara R Jones; Fiscal Year: 2013..We have found that the behavioral and neurochemical responses to fluoxetine are qualitatively transformed...
- The contributions of motor learning and inhibitory balance to stroke recoverySteven R Zeiler; Fiscal Year: 2013..period by describing how the timing and dose of motor retraining interact to affect motor recovery, how fluoxetine (a commonly used anti-depressant medicine) can modify the sensitive period, and how specific neuronal activity ..
- Automated Interactive Text Messaging to Assess Adolescent DepressionJAMES C contact MUNDT; Fiscal Year: 2010..with major depression will be recruited from the NIH-sponsored "Pediatric MDD: Sequential Treatment with Fluoxetine and Relapse Prevention CBT" (MH039188;Dr. Graham Emslie, PI)...
- ENVIRONMENTAL AND PHARMACOLOGICAL CONTROL OF DRUG ABUSEMarilyn Carroll; Fiscal Year: 2000..be given pharmacological treatments throughout, such as buprenorphine,an opiate mixed agonist-antagonist, and fluoxetine, serotonin reuptake blocker, which have some efficacy in reducing cocaine self- administration in animals and ..
- Necessity of Neurogenesis for Antidepressant EfficacyTARIQUE DHYAN PERERA; Fiscal Year: 2013..We have also obtained preliminary evidence that fluoxetine stimulates hippocampal neurogenesis and prevents depressive behavior and that both effects are abolished by ..
- Depression: Synaptic mediation in sleep deprivationPingfu Feng; Fiscal Year: 2013..Aim 2 will compare the alterations of SAPs in a rat model of depression among treatments with SD, orexins and fluoxetine. We will first compare the short-term effects of SD by gentle handling to that of SD by orexin and the acute ..
- Comparative Effectiveness Research Diffusion and Mental Health Care DisparitiesBENJAMIN LE COOK; Fiscal Year: 2013..g., fluoxetine use and metabolic screening for antipsychotic users);and b) psychotropic drug use that is potentially harmful (e...
- Repeated Partial Sleep Deprivation to Augment SSRI Response in DepressionJ Todd Arnedt; Fiscal Year: 2012..Our data further suggest that non-responders to fluoxetine treatment have shorter REM latency and more REM sleep than non-responders, particularly in the last few hours of ..
- Selective neuronal silencing to study hippocampal neurogenesis in depressionJoanna L Jankowsky; Fiscal Year: 2013..Our strategy will allow us to examine the function of adult-born neurons without destroying them, with the goal of more precisely defining the relationship between neurogenesis, depression, and therapeutic recovery. ..
- MECHANISMS OF ACTIVE NEUROTRANSMITTER TRANSPORTShimon Schuldiner; Fiscal Year: 2013..Hence the study of the mode of action of the neurotransporters, as proposed in this research project, is fundamental for understanding the communication between nerve cells in the normal and diseased brain. ..
- 2/2-Prevention of Relapse &Recurrence of Bipolar DepressionJohn M Zajecka; Fiscal Year: 2013..In this proposal, we will ask: "Does continuation therapy with combined lithium plus fluoxetine result in fewer MDE relapses and recurrences vs...
- Pediatric MDD: Sequential Treatment with Fluoxetine and Relapse Prevention CBTBeth D Kennard; Fiscal Year: 2012..demonstrating 1) continuity of the pathophysiology of depression in the pediatric age group, 2) efficacy of fluoxetine over placebo in pediatric depression, and most recently, 3) continued use of fluoxetine beyond acute treatment ..
- TDM & Drug Interactions in HIVinfected Substance AbusersGene Morse; Fiscal Year: 2007..and commonly prescribed medications including methadone, ethinyl estradiol, fluconazole, pravastatin, and fluoxetine in HIV-infected, substance abusers The proposed methodology employs a Therapeutic Drug Monitoring (TDM) program ..
- Time Course and Potentiation of Fluoxetin ActionGeorge Battaglia; Fiscal Year: 2004..The introduction of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac) has revolutionized psychiatry...
- SEROTONIN Treatment of Cocaine DependenceERIC STRAIN; Fiscal Year: 2005..Since this renewal shifts focus from tryptophan to another medication that alters serotonin functioning (fluoxetine), it has been re-titled "Serotonin Treatment of Cocaine Dependence...
- Galanin and GaIR2 receptors in antidepressant treatmentsTamas Bartfai; Fiscal Year: 2005..that galanin is 1 of the 8 transcripts that are significantly elevated by at least 2 antidepressant treatments, fluoxetine and electroconvulsive therapy, in the rat DRN...
- Galanin and GalR2 Receptors in Antidepressant TreatmentsTamas Bartfai; Fiscal Year: 2009..galanin is one of the 8 transcripts that are significantly elevated by at least two antidepressant treatments, fluoxetine and electroconvulsive therapy, in the rat DRN...
- FLUOXETINES EFFECT ON ANXIETY AND BREATHING IN CHILDRENDaniel Pine; Fiscal Year: 2000..Pilot data from open studies suggest that fluoxetine holds promise as a treatment for childhood social phobia, separation anziety, and generalized anxiety disorders...
- MOOD EFFECT OF TESTOSTERONE VS FLUOXETINE IN HIV ILLNESSJudith Rabkin; Fiscal Year: 2000..continuation application, the primary goal is to evaluate the antidepressant effects of testosterone compared to fluoxetine in a double-blind randomized placebo controlled clinical trial for HIV-positive patients with major depression ..
- SEROTONIN AND IMPULSIVE AGGRESSION--TREATMENT CORRELATESEMIL COCCARO; Fiscal Year: 2000..period, the applicant conducted an experimental clinical trial in which the selective 5-HT uptake inhibitor, Fluoxetine, was found to significantly reduce the frequency and severity of impulsive aggressive behaviors in a 12-week ..
- EFFECT OF SRIs ON GONADAL STEROIDSMargaret Altemus; Fiscal Year: 2006..determine whether this effect is a specific characteristic of SRIs, the effect of chronic treatment with an SRI, fluoxetine, on the gonadal steroid precursor hormone 17a-OH pregnenolone will be compared to the effect of a non-SRI, ..