- Polyamines and cancer: old molecules, new understanding
Eugene W Gerner
University of Arizona, Tucson, Arizona 85724, USA
Nat Rev Cancer 4:781-92. 2004
The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism...
- Polyamines are required for virulence in Salmonella enterica serovar Typhimurium
Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
PLoS ONE 7:e36149. 2012
..Here we identify polyamines as novel environmental signals essential for virulence of Salmonella enterica serovar Typhimurium, a major ..
- Modulation of cellular function by polyamines
Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
Int J Biochem Cell Biol 42:39-51. 2010
b>Polyamines (putrescine, spermidine and spermine) are essential for normal cell growth. The polyamine levels in cells are regulated by biosynthesis, degradation, and transport...
- Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease
Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York, USA
Clin J Am Soc Nephrol 7:934-42. 2012
- Polyamine catabolism and disease
Robert A Casero
Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Biochem J 421:323-38. 2009
..The goal of the present review is to cover those aspects of polyamine catabolism that have an impact on disease aetiology or treatment and to provide a solid background in this ever more exciting aspect of polyamine biology...
- Polyamines in aging and disease
University of St Andrews, School of Biology, St Andrews, Fife, UK
Aging (Albany NY) 3:716-32. 2011
b>Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation...
- Polyamines in microorganisms
C W Tabor
Microbiol Rev 49:81-99. 1985
- Polyamines are required for the expression of key Hms proteins important for Yersinia pestis biofilm formation
Brian W Wortham
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
Environ Microbiol 12:2034-47. 2010
..In this article we show that polyamines are necessary to maintain the levels of key Hms proteins...
- Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients
Juan F Navarro-González
Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Clin J Am Soc Nephrol 6:2272-9. 2011
..We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and sCD14 levels in HD patients...
- Polyamines: essential factors for growth and survival
Graduate School of Life Sciences, Tohoku University, 2 1 1 Karahira, Aoba, Sendai, Miyagi, 980 8577, Japan
Planta 228:367-81. 2008
b>Polyamines are low molecular weight, aliphatic polycations found in the cells of all living organisms. Due to their positive charges, polyamines bind to macromolecules such as DNA, RNA, and proteins...
- Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery
Dana J Gary
School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
J Control Release 121:64-73. 2007
- Polyamines: mysterious modulators of cellular functions
Faculty of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba, 263 8522, Japan
Biochem Biophys Res Commun 271:559-64. 2000
In recent years the functions of polyamines (putrescine, spermidine, and spermine) have been studied at the molecular level...
- The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer
Department of Nephrology, University Federico II, Naples, Italy
Kidney Int 72:1255-61. 2007
..Our study shows that sevelamer treatment should not be restricted to dialysis patients; however, a larger study should be undertaken to confirm these results...
- Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick 08903, USA
Cell Mol Life Sci 58:244-58. 2001
b>Polyamines are aliphatic cations with multiple functions and are essential for life...
- Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
Varun K Gupta
1 Institute for Biology Genetics, Freie Universitat Berlin, Berlin, Germany 2 NeuroCure, Charite, Berlin, Germany
Nat Neurosci 16:1453-60. 2013
..b>Polyamines are among the substances found to decrease with age in the human brain...
- Polyamines are present in mast cell secretory granules and are important for granule homeostasis
Department of Molecular Biology and Biochemistry, and CIBER de Enfermedades Raras CIBER ER, Faculty of Sciences, University of Malaga, Malaga, Spain
PLoS ONE 5:e15071. 2010
..b>Polyamines (putrescine, spermidine and spermine) are absolutely required for the survival of the vast majority of living ..
- Endogenous polyamines regulate cortical neuronal excitability by blocking voltage-gated Na+ channels
Ilya A Fleidervish
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 105:18994-9. 2008
..we report on a novel neuromodulatory mechanism that links the availability of Na(+) channels to metabolism of polyamines (PAs) in the cerebral cortex...
- Polyamines: metabolism and implications in human diseases
Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, 4, avenue de l Observatoire, 75270 Paris Cedex 06, France
Clin Nutr 24:184-97. 2005
Classically, polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process...
- Effect of salt and osmotic stress on changes in polyamine content and arginine decarboxylase activity in Lupinus luteus seedlings
Department of Plant Physiology, Faculty of Biology, Adam Mickiewicz University, Al Niepodległości 14, 61 713 Poznan, Poland
J Plant Physiol 162:662-8. 2005
..in the roots and leaves of lupin growing under the stress condition (NaCl or sorbitol), a higher level of polyamines (PAs) bound to microsomal membranes was observed...
- Polyamine metabolic canalization in response to drought stress in Arabidopsis and the resurrection plant Craterostigma plantagineum
Max Planck Institute for Plant Breeding Research, Cologne, Germany
Plant Signal Behav 6:243-50. 2011
..Our results provide a new insight to the polyamine homeostasis mechanisms during drought stress acclimation in Arabidopsis and resurrection plants...
- Sevelamer decreases systemic inflammation in parallel to a reduction in endotoxemia
A E M Stinghen
Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Curitiba, PR, Brazil
Blood Purif 29:352-6. 2010
..In the present study, we investigated the impact of sevelamer hydrochloride treatment in reducing endotoxemia and inflammation in a group of hemodialysis (HD) patients...
- Nuclear aggregates of polyamines are supramolecular structures that play a crucial role in genomic DNA protection and conformation
Department of Clinical and Experimental Medicine, Federico II University of Naples, Italy
FEBS J 272:3777-87. 2005
In a previous study we showed that natural polyamines interact in the nuclear environment with phosphate groups to form molecular aggregates [nuclear aggregates of polyamines (NAPs)] with estimated molecular mass values of 8000, 4800 and ..
- Polyamines, polyamine oxidases and nitric oxide in development, abiotic and biotic stresses
Leibniz University of Hannover, Institute of Floriculture and Wood Science, Section of Molecular Developmental Physiology, Herrenhauser Str 2, D 30419 Hannover, Germany
Plant Sci 181:593-603. 2011
Nitric oxide (NO), polyamines (PAs), diamine oxidases (DAO) and polyamine oxidases (PAO) play important roles in wide spectrum of physiological processes such as germination, root development, flowering and senescence and in defence ..
- A multifaceted role for polyamines in bacterial pathogens
Department of Microbiology, University of Mississippi Medical Center, 2500 N State Street Jackson, MS 39216, USA
Mol Microbiol 68:4-16. 2008
b>Polyamines are polycationic molecules with a hydrocarbon backbone and multiple amino groups. Descriptions of the physiological roles of polyamines have often been limited to their interaction with negatively charged nucleic acids...
- A perspective of polyamine metabolism
Heather M Wallace
Department of Medicine and Therapeutics, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Biochem J 376:1-14. 2003
b>Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both electrostatically and covalently and, as a consequence, have a variety of cellular effects...
- Polyamines: molecules with regulatory functions in plant abiotic stress tolerance
Max Planck Institut fur Zuchtungsforschung, Carl von Linne Weg 10, 50829 Cologne, Germany
Planta 231:1237-49. 2010
..last few years, genetic, transcriptomic and metabolomic approaches have unravelled key functions of different polyamines in the regulation of abiotic stress tolerance...
- Polyamines and abiotic stress: recent advances
M D Groppa
Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
Amino Acids 34:35-45. 2008
In this review we will concentrate in the results published the last years regarding the involvement of polyamines in the plant responses to abiotic stresses, most remarkably on salt and drought stress...
- Polyamines induce rapid biosynthesis of nitric oxide (NO) in Arabidopsis thaliana seedlings
Ni Ni Tun
Universitat Hannover, Institut für Zierpflanzenbau, AG Molekulare Ertragsphysiologie, Germany
Plant Cell Physiol 47:346-54. 2006
..method employing the cell-impermeable NO-binding dye diaminorhodamine-4M (DAR-4M), we observed that the polyamines (PAs) spermidine and spermine greatly increased NO release in the seedlings, whereas arginine and putrescine had ..
- Regulation of ornithine decarboxylase
Anthony E Pegg
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Biol Chem 281:14529-32. 2006
..This review describes key factors that contribute to the regulation of ODC levels, which can occur at the levels of transcription, translation, and protein turnover...
- Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
W N Suki
Renal Section, Department of Medicine, The Kidney Institute, Baylor College of Medicine, Houston, Texas 77054, USA
Kidney Int 72:1130-7. 2007
..There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings...
- Polyamines: natural and engineered abiotic and biotic stress tolerance in plants
Syed Sarfraz Hussain
Australian Centre for Plant Functional Genomics ACPFG, University of Adelaide, PMB1, Glen Osmond, SA5064, Australia
Biotechnol Adv 29:300-11. 2011
b>Polyamines (PAs) are ubiquitous biogenic amines that have been implicated in diverse cellular functions in widely distributed organisms...
- Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
N D Sonawane
Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
J Biol Chem 278:44826-31. 2003
..postulates enhanced transgene delivery by cationic polymer-DNA complexes (polyplexes) containing H+ buffering polyamines by enhanced endosomal Cl- accumulation and osmotic swelling/lysis...
- Polyamine-rich food decreases age-associated pathology and mortality in aged mice
Department of Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, Saitama, Japan
Exp Gerontol 44:727-32. 2009
The purpose of this study was to test whether oral intake of foods rich in polyamines (spermine and spermidine) suppresses age-associated pathology in aged mice...
- Polyamines: fundamental characters in chemistry and biology
Department of Biochemical Sciences, Biology and Molecular Pathology Institutes, SAPIENZA University of Rome and CNR, Piazzale Aldo Moro 5, 00185, Rome, Italy
Amino Acids 38:393-403. 2010
b>Polyamines are small cationic molecules required for cellular proliferation and are detected at higher concentrations in most tumour tissues, compared to normal tissues...
- Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro
Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10024, USA
Neuron 35:711-9. 2002
..We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis...
- Long-term comparison of a calcium-free phosphate binder and calcium carbonate--phosphorus metabolism and cardiovascular calcification
KfH Dialysezentrum Nürnberg, Germany
Clin Nephrol 62:104-15. 2004
..Calcium carbonate used as a phosphate binder may contribute to cardiovascular calcification. Long-term comparisons of sevelamer, a non-calcium polymeric phosphate binder, and calcium carbonate (CC) are lacking...
- Modulation of the polyamine biosynthetic pathway in transgenic rice confers tolerance to drought stress
Department of Crop Genetics and Biotechnology, Fraunhofer IME, Auf dem Aberg 1, D 57392 Schmallenberg, Germany
Proc Natl Acad Sci U S A 101:9909-14. 2004
..We demonstrate clearly that the manipulation of polyamine biosynthesis in plants can produce drought-tolerant germplasm, and we propose a model consistent with the role of polyamines in the protection of plants against abiotic stress.
- Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy?
Rodrigo B Oliveira
Nephrology Department, Universidade de Sao Paulo, Sao Paulo, Brazil
Clin J Am Soc Nephrol 5:286-91. 2010
..This short-term 6-wk dose titration study evaluated the effect of two phosphate binders on PTH and FGF23 levels in patients with CKD stages 3 to 4...
- Sevelamer hydrochloride use and circulating endotoxin in hemodialysis patients: a pilot cross-sectional study
Phyllis P Sun
Kidney and Dialysis Research Laboratory, Division of Nephrology, Department of Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
J Ren Nutr 19:432-8. 2009
..This study explores the hypothesis that sevelamer hydrochloride binds bacterial endotoxin in the intestinal tract, leading to lower circulating endotoxin levels, and offering a novel anti-inflammatory mechanism...
- Evaluation of calcium acetate/magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: a controlled randomized study (CALMAG study) assessing efficacy and tolerability
Angel L M de Francisco
Hospital Marques de Valdecilla, Universidad de Cantabria, Santander, Spain
Nephrol Dial Transplant 25:3707-17. 2010
..Phosphate binders are required to control serum phosphorus in dialysis patients. A phosphate binder combining calcium and magnesium offers an interesting therapeutic option...
- Independent roles of eIF5A and polyamines in cell proliferation
Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
Biochem J 385:779-85. 2005
To examine the roles of active hypusinated eIF5A (eukaryotic translation initiation factor 5A) and polyamines in cell proliferation, mouse mammary carcinoma FM3A cells were treated with an inhibitor of deoxyhypusine synthase, GC7 (N1-..
- Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats
Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
Kidney Int 64:441-50. 2003
..This study examined the efficacy of sevelamer in preventing ectopic calcification of soft tissues and ROD in adenine-induced renal failure rats...
- Complex inhibition of OmpF and OmpC bacterial porins by polyamines
Department of Biology, University of Houston, Houston, Texas 77204 5513, USA
J Biol Chem 272:18595-601. 1997
The effects of four polyamines (putrescine, cadaverine, spermidine, and spermine) on the activity of bacterial porins OmpC and OmpF were investigated by electrophysiology...
- Polyamines on the reproductive landscape
Pavine L C Lefèvre
Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, Saint Hyacinthe, Canada QC J2S 2M2
Endocr Rev 32:694-712. 2011
The polyamines are ubiquitous polycationic compounds...
- Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
Am J Kidney Dis 57:422-31. 2011
..Effects of phosphate binders on circulating advanced glycation end products (AGEs) are unknown...
- Involvement of polyamines in plant response to abiotic stress
Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
Biotechnol Lett 28:1867-76. 2006
Environmental stresses are the major cause of crop loss worldwide. Polyamines are involved in plant stress responses. However, the precise role(s) of polyamine metabolism in these processes remain ill-defined...
- Overexpression of arginase in Arabidopsis thaliana influences defence responses against Botrytis cinerea
Laboratory of Plant Genetics, Institute for Molecular Biology and Biotechnology, Vrije Universiteit Brussel VUB, Brussels, Belgium
Plant Biol (Stuttg) 14:39-45. 2012
..cinerea, whereas silencing lines remained as susceptible as the wild type. We discuss how arginase might interact with plant defence mechanisms. These results provide new insights into amino acid metabolic changes under stress...
- Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
J Biol Chem 281:19387-94. 2006
b>Polyamines are essential for maintaining normal intestinal epithelial integrity, an effect that relies, at least in part, on their ability to keep low levels of nucleophosmin (NPM) and p53 mRNAs...
- Montmorillonite-supramolecular hydrogel hybrid for fluorocolorimetric sensing of polyamines
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto, 615 8510, Japan
J Am Chem Soc 133:1670-3. 2011
Fluorescent sensor materials for rapidly and conveniently detecting polyamines in biological fluids are highly desirable for cancer diagnosis...
- Effects of sevelamer and calcium-based phosphate binders on lipid and inflammatory markers in hemodialysis patients
Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, Calif 90502, USA
Am J Nephrol 28:275-9. 2008
..A combination of lipid-lowering and anti-inflammatory effects along with avoidance of hypercalcemia should be taken into account when choosing phosphorus binders for maintenance hemodialysis (MHD) patients...
- Detection of prostate cancer with MR spectroscopic imaging: an expanded paradigm incorporating polyamines
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
Radiology 245:499-506. 2007
- Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines
Jin Young Kim
Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 84:70-8. 2011
..lumen is an essential substrate for the synthesis of nitric oxide (NO), by nitric oxide synthase (NOS), and polyamines, via arginase and ornithine decarboxylase, that are required for survival and development of ovine conceptuses (..
- Plant amine oxidases "on the move": an update
Dipartimento di Biologia, Universita degli Studi Roma Tre, Viale Guglielmo Marconi 446, 00146 Rome, Italy
Plant Physiol Biochem 48:560-4. 2010
Amine oxidases (AOs) catalyse the oxidative de-amination of polyamines, ubiquitous polycationic compounds involved in important events of cell life. They include the copper-containing amine oxidases (CuAOs; EC 1.4.3...
- Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
J Biol Chem 282:8404-13. 2007
..characterized by increased N1-acetyltransferase activity, a marked elevation in tissue and urinary acetylated polyamines, a compensatory increase in polyamine biosynthetic enzyme activity, and an increase in metabolic flux through ..
- DNA interaction with antitumor polyamine analogues: a comparison with biogenic polyamines
C N N'soukpoé-Kossi
Departement de Chimie Biologie, Universite du Quebec a Trois Rivieres, C P 500, Trois Rivieres Quebec, G9A 5H7, Canada
Biomacromolecules 9:2712-8. 2008
Biogenic polyamines, putrescine, spermidine, and spermine, are ubiquitous cellular cations and exert multiple biological functions...
- Delivery of RNA interference therapeutics using polycation-based nanoparticles
Kenneth Alan Howard
Interdisciplinary Nanoscience Center iNANO, Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Denmark
Adv Drug Deliv Rev 61:710-20. 2009
..This work highlights the versatile nature of polycation-based nanoparticles to fulfil the delivery requirements for RNA molecules with flexibility in design to evolve alongside an expanding repertoire of RNAi-based drugs...
- Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Am Chem Soc 125:5316-23. 2003
..This work highlights the value of parallel synthesis and screening approaches for the discovery of new polymers for gene delivery and the elucidation of structure/function relationships for this important class of materials...
- Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods
Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK
Mol Microbiol 74:529-40. 2009
..The synthetase function of TRYS is thus unequivocally validated as a drug target by both chemical and genetic methods...
- Epibrassinolide induces changes in indole-3-acetic acid, abscisic acid and polyamine concentrations and enhances antioxidant potential of radish seedlings under copper stress
Sikander Pal Choudhary
Department of Botany, University of Jammu, Jammu 180001, India
Physiol Plant 140:280-96. 2010
- Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines
Institut de Biologie de l Ecole Normale Supérieure IBENS, Ecole Normale Superieure, CNRS UMR 8197, Inserm U1024, Paris, France
EMBO J 30:3134-46. 2011
..Here, we show that polyamines, naturally occurring polycations that selectively enhance NMDARs containing the GluN2B subunit, bind at a dimer ..
- COPPER AMINE OXIDASE1 (CuAO1) of Arabidopsis thaliana contributes to abscisic acid- and polyamine-induced nitric oxide biosynthesis and abscisic acid signal transduction
Leibniz Universitat Hannover, Institute of Floriculture and Wood Science, Section of Applied Molecular Physiology, Herrenhauser Strasse 2, D 30419 Hannover, Germany
Mol Plant 4:663-78. 2011
b>Polyamines (PA), polyamine oxidases, copper amine oxidases, and nitric oxide (NO) play important roles in physiology and stress responses in plants...
- Sevelamer hydrochloride, a phosphate binder, protects against deterioration of renal function in rats with progressive chronic renal insufficiency
Pharmaceutical Development Laboratories, Kirin Brewery Co, Ltd, 3 Miyahara cho, Takasaki shi, Gunma 370 1295, Japan
Nephrol Dial Transplant 18:2014-23. 2003
..This study examined whether sevelamer hydrochloride (Renagel(R); 'sevelamer' hereafter), a non-calcaemic phosphate binder could slow deterioration of renal function in rats with progressive renal insufficiency...
- Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles
Derek W Bartlett
Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Bioconjug Chem 18:456-68. 2007
..The analysis of the CDP delivery vehicle provides insights that can be applied to the design of targeted nucleic acid delivery vehicles in general...
- Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase
A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
J Invest Dermatol 116:801-5. 2001
..Hair follicles were replaced by dermal cysts and epidermal utriculi. Analysis of skin polyamines revealed that the transgenic animals continuously overaccumulated putrescine...
- Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
John V W Becker
CSIR Biosciences, PO Box 395, Pretoria, 0001, South Africa
BMC Genomics 11:235. 2010
..falciparum spermidine synthase (PfSpdSyn) were examined on a morphological, transcriptomic, proteomic and metabolic level...
- The antizyme family: polyamines and beyond
Program in Vascular Biology, Department of Surgery, Children s Hospital, Boston, MA 02115, USA
IUBMB Life 57:671-6. 2005
- The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations
D L Jack
Department of Biology, University of California at San Diego, La Jolla, CA 92093 0116, USA
Microbiology 146:1797-814. 2000
..Altogether, the APC superfamily probably includes 12 currently recognized families with members that exhibit exclusive specificity for amino acids and their derivatives but which can possess 10, 11, 12 or 14 TMSs per polypeptide chain...
- Dendrimers in biomedical applications--reflections on the field
Dendritic NanoTechnologies, Inc, 2625 Denison Drive, Mount Pleasant, MI 48858, USA
Adv Drug Deliv Rev 57:2106-29. 2005
..The reflections on biomedical applications of dendrimers given in this review clearly demonstrate the potential of this new fourth major class of polymer architecture and indeed substantiate the high hopes for the future of dendrimers...
- Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3' untranslated region to HuR and AUF1
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Mol Cell Biol 30:5021-32. 2010
b>Polyamines critically regulate all mammalian cell growth and proliferation by mechanisms such as the repression of growth-inhibitory proteins, including JunD...
- Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21224, USA
Nucleic Acids Res 37:7623-37. 2009
..Ectopic HuR overexpression or elevated cytoplasmic levels of endogenous HuR by decreasing cellular polyamines increased [HuR/XIAP mRNA] complexes, in turn promoting XIAP mRNA stability and increasing XIAP protein abundance...
- Phenolamides: bridging polyamines to the phenolic metabolism
Jean Etienne Bassard
Institute of Plant Molecular Biology, CNRS UPR 2357, University of Strasbourg, 28 rue Goethe, 67000 Strasbourg, France
Phytochemistry 71:1808-24. 2010
..and quantitatively major group of secondary metabolites resulting from the conjugation of a phenolic moiety with polyamines or with deaminated aromatic aminoacids...
- Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation
Cell Biology Group, Department of Surgery, and Department of Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
Mol Biol Cell 20:4885-98. 2009
All mammalian cells depend on polyamines for normal growth and proliferation, but the exact roles of polyamines at the molecular level remain largely unknown...
- Involvement of potD in Streptococcus pneumoniae polyamine transport and pathogenesis
Mississippi Department of Health, Public Health Laboratory, 570 East Woodrow Wilson Drive, Jackson, MS 39216, USA
Infect Immun 74:352-61. 2006
b>Polyamines such as putrescine, spermidine, and cadaverine are small, polycationic molecules that are required for optimal growth in all cells...
- Polyamines and abiotic stress tolerance in plants
Sarvajeet Singh Gill
International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
Plant Signal Behav 5:26-33. 2010
..crop yields under adverse environmental stresses is probably the major challenge facing modern agriculture where polyamines can play important role...
- Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA
IC Vec Ltd, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom
Biochemistry 43:13348-56. 2004
..By contrast, LsiR particles formulated from lipofectAMINE2000 accumulate in fewer larger intracellular vesicles...
- NO signal at the crossroads: polyamine-induced nitric oxide synthesis in plants?
Faculty of Science, University of the Ryukyus, Okinawa 903 0213, Japan
Trends Plant Sci 11:522-4. 2006
b>Polyamines, such as spermine, spermidine and putrescine, are ubiquitous polycationic compounds that are produced by almost all living organisms, including plants, animals, fungi and bacteria...
- Polyamine metabolism and cancer
Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
J Cell Mol Med 7:113-26. 2003
b>Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are intricately controlled by biosynthetic and catabolic enzymes...
- Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis
Panagiotis N Moschou
Department of Biology, University of Crete, 71409 Heraklion, Greece
Plant Physiol 147:1845-57. 2008
..The overall data reinforce the view that plants and mammals possess a similar PA oxidation system, concerning both the subcellular localization and the mode of its action...
- Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding
J J Almrud
Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA
J Mol Biol 295:7-16. 2000
The polyamines spermidine and spermine are ubiquitous and required for cell growth and differentiation in eukaryotes. Ornithine decarboxylase (ODC, EC 4.1.1...
- Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis
Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
Clin J Am Soc Nephrol 3:1125-30. 2008
..This study investigated the ability of sevelamer carbonate to control serum phosphorous in hyperphosphatemic patients who had chronic kidney disease and were not on dialysis...
- Functions of amine oxidases in plant development and defence
Dipartimento di Biologia, Universita degli Studi Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
Trends Plant Sci 11:80-8. 2006
Copper amine oxidases and flavin-containing amine oxidases catalyse the oxidative de-amination of polyamines, which are ubiquitous compounds essential for cell growth and proliferation...
- An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae
Departments of Pharmacology, Microbiology, and Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
J Biol Chem 284:9899-907. 2009
b>Polyamines are small organic cations found in all cells, and the biosynthetic pathway is well described in eukaryotes and Escherichia coli...
- Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy
Renal Division, Department of Pediatrics, Washington University School of Medicien, St Louis, Missouri 63110, USA
J Am Soc Nephrol 18:122-30. 2007
..These results suggest that sevelamer may have important actions in decreasing diabetic and uremic vasculopathy and that sevelamer carbonate may be capable of increasing bone formation rates that are suppressed by diabetic nephropathy...
- Effects of polyamines on the thermal stability and formation kinetics of DNA duplexes with abnormal structure
M H Hou
Institute of Chemistry, Academia Sinica, Taipei, 115 Taiwan
Nucleic Acids Res 29:5121-8. 2001
The effects of ions (i.e. Na+, Mg2+ and polyamines including spermidine and spermine) on the stability of various DNA oligonucleotides in solution were studied...
- In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis
Department of Pharmaceutics and Biopharmacy, University of Marburg, Ketzerbach 63, 35032, Marburg, Germany
Biomaterials 24:1121-31. 2003
..fmk did not inhibit poly(ethylenimine)-induced cell damage. Insights into the structure-toxicity relationship are necessary to optimize the cytotoxicity and biocompatibility of non-viral gene delivery systems...
- Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer
Arizona Cancer Center, and Biochemistry, Molecular and Cellular Biology Graduate Program, The University of Arizona, Tucson, 85724, USA
J Biol Chem 278:47762-75. 2003
..These data suggest that apoptosis induced by sulindac sulfone is mediated, in part, by the COX-independent, PPAR-dependent transcriptional activation of SSAT, leading to reduced tissue polyamine contents in human colon cancer cells...
- Relative in vitro efficacy of the phosphate binders lanthanum carbonate and sevelamer hydrochloride
School of Natural Sciences Chemistry, University of Newcastle, Newcastle upon Tyne, UK
J Pharm Sci 96:2818-27. 2007
..These findings indicate that LC binds phosphate more effectively than SH across the pH range encountered in the gastrointestinal tract, and has a lower propensity for bound phosphate to be displaced by competing anions in the intestine...
- Positive charges of polyamines protect PSII in isolated thylakoid membranes during photoinhibitory conditions
Groupe de Recherche en Biologie Végétale, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada G9A 5H7
Plant Cell Physiol 52:866-73. 2011
..This protection was probably provided by the polycationic nature of SPM (four positive charges at physiological pH), which can stabilize surface-exposed proteins of PSII through electrostatic interaction...
- Enhanced susceptibility of photosynthesis to low-temperature photoinhibition due to interruption of chill-induced increase of S-adenosylmethionine decarboxylase activity in leaves of spinach (Spinacia oleracea L.)
Department of Life Science, Faculty of Bioresources, Mie University, Tsu, 514 8507 Japan
Plant Cell Physiol 43:196-206. 2002
The possible involvement of polyamines in the chilling tolerance of spinach (Spinacia oleracea L.) was investigated focusing on photosynthesis...
- Lanthanum carbonate, like sevelamer-HCl, retards the progression of vascular calcification and atherosclerosis in uremic apolipoprotein E-deficient mice
Igor G Nikolov
INSERM ERI 12, UFR de Médecine Pharmacie, University of Picardie, Amiens, France
Nephrol Dial Transplant 27:505-13. 2012
..We compared the effect of phosphate binder lanthanum (La) carbonate with sevelamer-HCl on atherosclerosis, VC and bone structure and function in mice with chronic renal failure (CRF)...
- Heterogeneous distribution of polyamines in temporal lobe epilepsy
Laboratory of Neurosciences, School of Medicine, University of Rennes, France
Epilepsy Res 35:161-72. 1999
..The opposite was observed for spermine. The heterogeneous distribution of polyamines was compared to abnormal electrical activities recorded by SEEG: SPD/SPM index and spermidine levels were ..
- Self-assembly of highly phosphorylated silaffins and their function in biosilica morphogenesis
Lehrstuhl Biochemie I, Institut fur Biophysik und Physikalische Biochemie, Universitat Regensburg, 93053 Regensburg, Germany
Science 298:584-6. 2002
..Time-resolved analysis of silica morphogenesis in vitro detected a plastic silaffin-silica phase, which may represent a building material for diatom biosilica...
- Managing chronic inflammation in the aging diabetic patient with CKD by diet or sevelamer carbonate: a modern paradigm shift
Division of Experimental Diabetes and Aging, Department of Geriatrics and Palliative Care, Mount Sinai School of Medicine, 1 Gustave Levy Place, NY 10029, USA
J Gerontol A Biol Sci Med Sci 67:1410-6. 2012
..If larger and longer studies confirm the hypothesis that one or both of these interventions reduce progression of CKD, it could represent a new paradigm in the management of complications in the type 2 diabetes patient with CKD...
- Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients
Nephrology Department, Hospital Curry Cabral, Lisboa, Portugal
J Am Soc Nephrol 19:405-12. 2008
..Further studies are required to assess whether these changes affect clinical outcomes, such as rates of fracture...
- Determination of polyamine metabolome in plasma and urine by ultrahigh performance liquid chromatography-tandem mass spectrometry method: application to identify potential markers for human hepatic cancer
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
Anal Chim Acta 791:36-45. 2013
..a UHPLC-MS/MS method has been developed and validated for simultaneous determination of polyamine precursors, polyamines, polyamine catabolite in human plasma and urine...
- A novel multidomain polyketide synthase is essential for zeamine production and the virulence of Dickeya zeae
Department of Plant Pathology, South China Agricultural University, Guangzhou 51642, People s Republich of China
Mol Plant Microbe Interact 24:1156-64. 2011
..e., zeamine and zeamine II, that were phytotoxins and potent antibiotics. These results have established the essential role of ZmsA in zeamine biosynthesis and presented a new insight on the molecular mechanisms of D. zeae pathogenicity...
- Interaction of brassinosteroids and polyamines enhances copper stress tolerance in raphanus sativus
Sikander Pal Choudhary
Department of Horticulture, Zhejiang University Hangzhou 310058, Zhejiang China
J Exp Bot 63:5659-75. 2012
Brassinosteroids (BRs) and polyamines (PAs) regulate various responses to abiotic stress, but their involvement in the regulation of copper (Cu) homeostasis in plants exposed to toxic levels of Cu is poorly understood...
- Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers
School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, People s Republic of China
Eur J Med Chem 40:1188-92. 2005
..Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of NSAIDs...
- Targeting cancer cells with dendrimers
Srinivasa Gopalan Sampathkumar
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
Chem Biol 12:5-6. 2005
- Disruption of gene YlODC reveals absolute requirement of polyamines for mycelial development in Yarrowia lipolytica
J F Jiménez-Bremont
Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Gto, Mexico
FEMS Yeast Res 1:195-204. 2001
b>Polyamines are required for cellular growth and differentiation. In mammals and fungi they are synthesized via a pathway involving ornithine decarboxylase (ODC), which transforms ornithine into putrescine...
- Enhancement of the synthesis of RpoE and StpA by polyamines at the level of translation in escherichia coli under heat shock conditions
Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288 0025, Japan
J Bacteriol 191:5348-57. 2009
Proteins whose synthesis is enhanced by polyamines at the level of translation were identified with a polyamine-requiring mutant cultured in the presence of 0.1% glucose and 0.02% glutamate at 42 degrees C...