Top Publications

  1. ncbi Polyamines and cancer: old molecules, new understanding
    Eugene W Gerner
    University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Cancer 4:781-92. 2004
  2. pmc Polyamines are required for virulence in Salmonella enterica serovar Typhimurium
    Lotte Jelsbak
    Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    PLoS ONE 7:e36149. 2012
  3. ncbi Modulation of cellular function by polyamines
    Kazuei Igarashi
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Int J Biochem Cell Biol 42:39-51. 2010
  4. pmc Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease
    Helen Vlassara
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York, USA
    Clin J Am Soc Nephrol 7:934-42. 2012
  5. pmc Polyamine catabolism and disease
    Robert A Casero
    Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Biochem J 421:323-38. 2009
  6. pmc Polyamines in aging and disease
    Nadege Minois
    University of St Andrews, School of Biology, St Andrews, Fife, UK
    Aging (Albany NY) 3:716-32. 2011
  7. pmc Polyamines in microorganisms
    C W Tabor
    Microbiol Rev 49:81-99. 1985
  8. pmc Polyamines are required for the expression of key Hms proteins important for Yersinia pestis biofilm formation
    Brian W Wortham
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Environ Microbiol 12:2034-47. 2010
  9. pmc Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients
    Juan F Navarro-González
    Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Clin J Am Soc Nephrol 6:2272-9. 2011
  10. ncbi Polyamines: essential factors for growth and survival
    T Kusano
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Karahira, Aoba, Sendai, Miyagi, 980 8577, Japan
    Planta 228:367-81. 2008

Research Grants

Detail Information

Publications354 found, 100 shown here

  1. ncbi Polyamines and cancer: old molecules, new understanding
    Eugene W Gerner
    University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Cancer 4:781-92. 2004
    The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism...
  2. pmc Polyamines are required for virulence in Salmonella enterica serovar Typhimurium
    Lotte Jelsbak
    Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    PLoS ONE 7:e36149. 2012
    ..Here we identify polyamines as novel environmental signals essential for virulence of Salmonella enterica serovar Typhimurium, a major ..
  3. ncbi Modulation of cellular function by polyamines
    Kazuei Igarashi
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Int J Biochem Cell Biol 42:39-51. 2010
    b>Polyamines (putrescine, spermidine and spermine) are essential for normal cell growth. The polyamine levels in cells are regulated by biosynthesis, degradation, and transport...
  4. pmc Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease
    Helen Vlassara
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York, USA
    Clin J Am Soc Nephrol 7:934-42. 2012
  5. pmc Polyamine catabolism and disease
    Robert A Casero
    Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Biochem J 421:323-38. 2009
    ..The goal of the present review is to cover those aspects of polyamine catabolism that have an impact on disease aetiology or treatment and to provide a solid background in this ever more exciting aspect of polyamine biology...
  6. pmc Polyamines in aging and disease
    Nadege Minois
    University of St Andrews, School of Biology, St Andrews, Fife, UK
    Aging (Albany NY) 3:716-32. 2011
    b>Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation...
  7. pmc Polyamines in microorganisms
    C W Tabor
    Microbiol Rev 49:81-99. 1985
  8. pmc Polyamines are required for the expression of key Hms proteins important for Yersinia pestis biofilm formation
    Brian W Wortham
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Environ Microbiol 12:2034-47. 2010
    ..In this article we show that polyamines are necessary to maintain the levels of key Hms proteins...
  9. pmc Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients
    Juan F Navarro-González
    Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Clin J Am Soc Nephrol 6:2272-9. 2011
    ..We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and sCD14 levels in HD patients...
  10. ncbi Polyamines: essential factors for growth and survival
    T Kusano
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Karahira, Aoba, Sendai, Miyagi, 980 8577, Japan
    Planta 228:367-81. 2008
    b>Polyamines are low molecular weight, aliphatic polycations found in the cells of all living organisms. Due to their positive charges, polyamines bind to macromolecules such as DNA, RNA, and proteins...
  11. ncbi Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery
    Dana J Gary
    School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Control Release 121:64-73. 2007
  12. ncbi Polyamines: mysterious modulators of cellular functions
    K Igarashi
    Faculty of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba, 263 8522, Japan
    Biochem Biophys Res Commun 271:559-64. 2000
    In recent years the functions of polyamines (putrescine, spermidine, and spermine) have been studied at the molecular level...
  13. ncbi The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer
    D Russo
    Department of Nephrology, University Federico II, Naples, Italy
    Kidney Int 72:1255-61. 2007
    ..Our study shows that sevelamer treatment should not be restricted to dialysis patients; however, a larger study should be undertaken to confirm these results...
  14. ncbi Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
    T Thomas
    Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick 08903, USA
    Cell Mol Life Sci 58:244-58. 2001
    b>Polyamines are aliphatic cations with multiple functions and are essential for life...
  15. ncbi Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
    Varun K Gupta
    1 Institute for Biology Genetics, Freie Universitat Berlin, Berlin, Germany 2 NeuroCure, Charite, Berlin, Germany
    Nat Neurosci 16:1453-60. 2013
    ..b>Polyamines are among the substances found to decrease with age in the human brain...
  16. pmc Polyamines are present in mast cell secretory granules and are important for granule homeostasis
    Gianni García-Faroldi
    Department of Molecular Biology and Biochemistry, and CIBER de Enfermedades Raras CIBER ER, Faculty of Sciences, University of Malaga, Malaga, Spain
    PLoS ONE 5:e15071. 2010
    ..b>Polyamines (putrescine, spermidine and spermine) are absolutely required for the survival of the vast majority of living ..
  17. pmc Endogenous polyamines regulate cortical neuronal excitability by blocking voltage-gated Na+ channels
    Ilya A Fleidervish
    Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 105:18994-9. 2008
    ..we report on a novel neuromodulatory mechanism that links the availability of Na(+) channels to metabolism of polyamines (PAs) in the cerebral cortex...
  18. ncbi Polyamines: metabolism and implications in human diseases
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, 4, avenue de l Observatoire, 75270 Paris Cedex 06, France
    Clin Nutr 24:184-97. 2005
    Classically, polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process...
  19. ncbi Effect of salt and osmotic stress on changes in polyamine content and arginine decarboxylase activity in Lupinus luteus seedlings
    Jolanta Legocka
    Department of Plant Physiology, Faculty of Biology, Adam Mickiewicz University, Al Niepodległości 14, 61 713 Poznan, Poland
    J Plant Physiol 162:662-8. 2005
    ..in the roots and leaves of lupin growing under the stress condition (NaCl or sorbitol), a higher level of polyamines (PAs) bound to microsomal membranes was observed...
  20. pmc Polyamine metabolic canalization in response to drought stress in Arabidopsis and the resurrection plant Craterostigma plantagineum
    Rubén Alcázar
    Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Plant Signal Behav 6:243-50. 2011
    ..Our results provide a new insight to the polyamine homeostasis mechanisms during drought stress acclimation in Arabidopsis and resurrection plants...
  21. ncbi Sevelamer decreases systemic inflammation in parallel to a reduction in endotoxemia
    A E M Stinghen
    Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Curitiba, PR, Brazil
    Blood Purif 29:352-6. 2010
    ..In the present study, we investigated the impact of sevelamer hydrochloride treatment in reducing endotoxemia and inflammation in a group of hemodialysis (HD) patients...
  22. ncbi Nuclear aggregates of polyamines are supramolecular structures that play a crucial role in genomic DNA protection and conformation
    Luciano D'Agostino
    Department of Clinical and Experimental Medicine, Federico II University of Naples, Italy
    FEBS J 272:3777-87. 2005
    In a previous study we showed that natural polyamines interact in the nuclear environment with phosphate groups to form molecular aggregates [nuclear aggregates of polyamines (NAPs)] with estimated molecular mass values of 8000, 4800 and ..
  23. ncbi Polyamines, polyamine oxidases and nitric oxide in development, abiotic and biotic stresses
    Rinukshi Wimalasekera
    Leibniz University of Hannover, Institute of Floriculture and Wood Science, Section of Molecular Developmental Physiology, Herrenhauser Str 2, D 30419 Hannover, Germany
    Plant Sci 181:593-603. 2011
    Nitric oxide (NO), polyamines (PAs), diamine oxidases (DAO) and polyamine oxidases (PAO) play important roles in wide spectrum of physiological processes such as germination, root development, flowering and senescence and in defence ..
  24. ncbi A multifaceted role for polyamines in bacterial pathogens
    Pratik Shah
    Department of Microbiology, University of Mississippi Medical Center, 2500 N State Street Jackson, MS 39216, USA
    Mol Microbiol 68:4-16. 2008
    b>Polyamines are polycationic molecules with a hydrocarbon backbone and multiple amino groups. Descriptions of the physiological roles of polyamines have often been limited to their interaction with negatively charged nucleic acids...
  25. pmc A perspective of polyamine metabolism
    Heather M Wallace
    Department of Medicine and Therapeutics, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Biochem J 376:1-14. 2003
    b>Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both electrostatically and covalently and, as a consequence, have a variety of cellular effects...
  26. ncbi Polyamines: molecules with regulatory functions in plant abiotic stress tolerance
    Rubén Alcázar
    Max Planck Institut fur Zuchtungsforschung, Carl von Linne Weg 10, 50829 Cologne, Germany
    Planta 231:1237-49. 2010
    ..last few years, genetic, transcriptomic and metabolomic approaches have unravelled key functions of different polyamines in the regulation of abiotic stress tolerance...
  27. ncbi Polyamines and abiotic stress: recent advances
    M D Groppa
    Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Amino Acids 34:35-45. 2008
    In this review we will concentrate in the results published the last years regarding the involvement of polyamines in the plant responses to abiotic stresses, most remarkably on salt and drought stress...
  28. ncbi Polyamines induce rapid biosynthesis of nitric oxide (NO) in Arabidopsis thaliana seedlings
    Ni Ni Tun
    Universitat Hannover, Institut für Zierpflanzenbau, AG Molekulare Ertragsphysiologie, Germany
    Plant Cell Physiol 47:346-54. 2006
    ..method employing the cell-impermeable NO-binding dye diaminorhodamine-4M (DAR-4M), we observed that the polyamines (PAs) spermidine and spermine greatly increased NO release in the seedlings, whereas arginine and putrescine had ..
  29. ncbi Regulation of ornithine decarboxylase
    Anthony E Pegg
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Biol Chem 281:14529-32. 2006
    ..This review describes key factors that contribute to the regulation of ODC levels, which can occur at the levels of transcription, translation, and protein turnover...
  30. ncbi Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
    W N Suki
    Renal Section, Department of Medicine, The Kidney Institute, Baylor College of Medicine, Houston, Texas 77054, USA
    Kidney Int 72:1130-7. 2007
    ..There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings...
  31. ncbi Polyamines: natural and engineered abiotic and biotic stress tolerance in plants
    Syed Sarfraz Hussain
    Australian Centre for Plant Functional Genomics ACPFG, University of Adelaide, PMB1, Glen Osmond, SA5064, Australia
    Biotechnol Adv 29:300-11. 2011
    b>Polyamines (PAs) are ubiquitous biogenic amines that have been implicated in diverse cellular functions in widely distributed organisms...
  32. ncbi Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
    N D Sonawane
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 278:44826-31. 2003
    ..postulates enhanced transgene delivery by cationic polymer-DNA complexes (polyplexes) containing H+ buffering polyamines by enhanced endosomal Cl- accumulation and osmotic swelling/lysis...
  33. ncbi Polyamine-rich food decreases age-associated pathology and mortality in aged mice
    Kuniyasu Soda
    Department of Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Exp Gerontol 44:727-32. 2009
    The purpose of this study was to test whether oral intake of foods rich in polyamines (spermine and spermidine) suppresses age-associated pathology in aged mice...
  34. ncbi Polyamines: fundamental characters in chemistry and biology
    E Agostinelli
    Department of Biochemical Sciences, Biology and Molecular Pathology Institutes, SAPIENZA University of Rome and CNR, Piazzale Aldo Moro 5, 00185, Rome, Italy
    Amino Acids 38:393-403. 2010
    b>Polyamines are small cationic molecules required for cellular proliferation and are detected at higher concentrations in most tumour tissues, compared to normal tissues...
  35. ncbi Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro
    Dongming Cai
    Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10024, USA
    Neuron 35:711-9. 2002
    ..We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis...
  36. ncbi Long-term comparison of a calcium-free phosphate binder and calcium carbonate--phosphorus metabolism and cardiovascular calcification
    J Braun
    KfH Dialysezentrum Nürnberg, Germany
    Clin Nephrol 62:104-15. 2004
    ..Calcium carbonate used as a phosphate binder may contribute to cardiovascular calcification. Long-term comparisons of sevelamer, a non-calcium polymeric phosphate binder, and calcium carbonate (CC) are lacking...
  37. pmc Modulation of the polyamine biosynthetic pathway in transgenic rice confers tolerance to drought stress
    Teresa Capell
    Department of Crop Genetics and Biotechnology, Fraunhofer IME, Auf dem Aberg 1, D 57392 Schmallenberg, Germany
    Proc Natl Acad Sci U S A 101:9909-14. 2004
    ..We demonstrate clearly that the manipulation of polyamine biosynthesis in plants can produce drought-tolerant germplasm, and we propose a model consistent with the role of polyamines in the protection of plants against abiotic stress.
  38. pmc Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy?
    Rodrigo B Oliveira
    Nephrology Department, Universidade de Sao Paulo, Sao Paulo, Brazil
    Clin J Am Soc Nephrol 5:286-91. 2010
    ..This short-term 6-wk dose titration study evaluated the effect of two phosphate binders on PTH and FGF23 levels in patients with CKD stages 3 to 4...
  39. ncbi Sevelamer hydrochloride use and circulating endotoxin in hemodialysis patients: a pilot cross-sectional study
    Phyllis P Sun
    Kidney and Dialysis Research Laboratory, Division of Nephrology, Department of Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Ren Nutr 19:432-8. 2009
    ..This study explores the hypothesis that sevelamer hydrochloride binds bacterial endotoxin in the intestinal tract, leading to lower circulating endotoxin levels, and offering a novel anti-inflammatory mechanism...
  40. pmc Evaluation of calcium acetate/magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: a controlled randomized study (CALMAG study) assessing efficacy and tolerability
    Angel L M de Francisco
    Hospital Marques de Valdecilla, Universidad de Cantabria, Santander, Spain
    Nephrol Dial Transplant 25:3707-17. 2010
    ..Phosphate binders are required to control serum phosphorus in dialysis patients. A phosphate binder combining calcium and magnesium offers an interesting therapeutic option...
  41. pmc Independent roles of eIF5A and polyamines in cell proliferation
    Kazuhiro Nishimura
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Biochem J 385:779-85. 2005
    To examine the roles of active hypusinated eIF5A (eukaryotic translation initiation factor 5A) and polyamines in cell proliferation, mouse mammary carcinoma FM3A cells were treated with an inhibitor of deoxyhypusine synthase, GC7 (N1-..
  42. ncbi Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats
    Kyoko Katsumata
    Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
    Kidney Int 64:441-50. 2003
    ..This study examined the efficacy of sevelamer in preventing ectopic calcification of soft tissues and ROD in adenine-induced renal failure rats...
  43. ncbi Complex inhibition of OmpF and OmpC bacterial porins by polyamines
    R Iyer
    Department of Biology, University of Houston, Houston, Texas 77204 5513, USA
    J Biol Chem 272:18595-601. 1997
    The effects of four polyamines (putrescine, cadaverine, spermidine, and spermine) on the activity of bacterial porins OmpC and OmpF were investigated by electrophysiology...
  44. ncbi Polyamines on the reproductive landscape
    Pavine L C Lefèvre
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, Saint Hyacinthe, Canada QC J2S 2M2
    Endocr Rev 32:694-712. 2011
    The polyamines are ubiquitous polycationic compounds...
  45. ncbi Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients
    Takatoshi Kakuta
    Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Am J Kidney Dis 57:422-31. 2011
    ..Effects of phosphate binders on circulating advanced glycation end products (AGEs) are unknown...
  46. ncbi Involvement of polyamines in plant response to abiotic stress
    Rubén Alcázar
    Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Biotechnol Lett 28:1867-76. 2006
    Environmental stresses are the major cause of crop loss worldwide. Polyamines are involved in plant stress responses. However, the precise role(s) of polyamine metabolism in these processes remain ill-defined...
  47. ncbi Overexpression of arginase in Arabidopsis thaliana influences defence responses against Botrytis cinerea
    S Brauc
    Laboratory of Plant Genetics, Institute for Molecular Biology and Biotechnology, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Plant Biol (Stuttg) 14:39-45. 2012
    ..cinerea, whereas silencing lines remained as susceptible as the wild type. We discuss how arginase might interact with plant defence mechanisms. These results provide new insights into amino acid metabolic changes under stress...
  48. ncbi Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs
    Tongtong Zou
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    J Biol Chem 281:19387-94. 2006
    b>Polyamines are essential for maintaining normal intestinal epithelial integrity, an effect that relies, at least in part, on their ability to keep low levels of nucleophosmin (NPM) and p53 mRNAs...
  49. ncbi Montmorillonite-supramolecular hydrogel hybrid for fluorocolorimetric sensing of polyamines
    Masato Ikeda
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto, 615 8510, Japan
    J Am Chem Soc 133:1670-3. 2011
    Fluorescent sensor materials for rapidly and conveniently detecting polyamines in biological fluids are highly desirable for cancer diagnosis...
  50. pmc Effects of sevelamer and calcium-based phosphate binders on lipid and inflammatory markers in hemodialysis patients
    Ronney Shantouf
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, Calif 90502, USA
    Am J Nephrol 28:275-9. 2008
    ..A combination of lipid-lowering and anti-inflammatory effects along with avoidance of hypercalcemia should be taken into account when choosing phosphorus binders for maintenance hemodialysis (MHD) patients...
  51. ncbi Detection of prostate cancer with MR spectroscopic imaging: an expanded paradigm incorporating polyamines
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    Radiology 245:499-506. 2007
  52. ncbi Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines
    Jin Young Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 84:70-8. 2011
    ..lumen is an essential substrate for the synthesis of nitric oxide (NO), by nitric oxide synthase (NOS), and polyamines, via arginase and ornithine decarboxylase, that are required for survival and development of ovine conceptuses (..
  53. ncbi Plant amine oxidases "on the move": an update
    Riccardo Angelini
    Dipartimento di Biologia, Universita degli Studi Roma Tre, Viale Guglielmo Marconi 446, 00146 Rome, Italy
    Plant Physiol Biochem 48:560-4. 2010
    Amine oxidases (AOs) catalyse the oxidative de-amination of polyamines, ubiquitous polycationic compounds involved in important events of cell life. They include the copper-containing amine oxidases (CuAOs; EC 1.4.3...
  54. ncbi Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA
    Jason Jell
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 282:8404-13. 2007
    ..characterized by increased N1-acetyltransferase activity, a marked elevation in tissue and urinary acetylated polyamines, a compensatory increase in polyamine biosynthetic enzyme activity, and an increase in metabolic flux through ..
  55. ncbi DNA interaction with antitumor polyamine analogues: a comparison with biogenic polyamines
    C N N'soukpoé-Kossi
    Departement de Chimie Biologie, Universite du Quebec a Trois Rivieres, C P 500, Trois Rivieres Quebec, G9A 5H7, Canada
    Biomacromolecules 9:2712-8. 2008
    Biogenic polyamines, putrescine, spermidine, and spermine, are ubiquitous cellular cations and exert multiple biological functions...
  56. ncbi Delivery of RNA interference therapeutics using polycation-based nanoparticles
    Kenneth Alan Howard
    Interdisciplinary Nanoscience Center iNANO, Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Denmark
    Adv Drug Deliv Rev 61:710-20. 2009
    ..This work highlights the versatile nature of polycation-based nanoparticles to fulfil the delivery requirements for RNA molecules with flexibility in design to evolve alongside an expanding repertoire of RNAi-based drugs...
  57. ncbi Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery
    Akin Akinc
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 125:5316-23. 2003
    ..This work highlights the value of parallel synthesis and screening approaches for the discovery of new polymers for gene delivery and the elucidation of structure/function relationships for this important class of materials...
  58. pmc Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods
    Susan Wyllie
    Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK
    Mol Microbiol 74:529-40. 2009
    ..The synthetase function of TRYS is thus unequivocally validated as a drug target by both chemical and genetic methods...
  59. ncbi Epibrassinolide induces changes in indole-3-acetic acid, abscisic acid and polyamine concentrations and enhances antioxidant potential of radish seedlings under copper stress
    Sikander Pal Choudhary
    Department of Botany, University of Jammu, Jammu 180001, India
    Physiol Plant 140:280-96. 2010
  60. pmc Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines
    Laetitia Mony
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Ecole Normale Superieure, CNRS UMR 8197, Inserm U1024, Paris, France
    EMBO J 30:3134-46. 2011
    ..Here, we show that polyamines, naturally occurring polycations that selectively enhance NMDARs containing the GluN2B subunit, bind at a dimer ..
  61. ncbi COPPER AMINE OXIDASE1 (CuAO1) of Arabidopsis thaliana contributes to abscisic acid- and polyamine-induced nitric oxide biosynthesis and abscisic acid signal transduction
    Rinukshi Wimalasekera
    Leibniz Universitat Hannover, Institute of Floriculture and Wood Science, Section of Applied Molecular Physiology, Herrenhauser Strasse 2, D 30419 Hannover, Germany
    Mol Plant 4:663-78. 2011
    b>Polyamines (PA), polyamine oxidases, copper amine oxidases, and nitric oxide (NO) play important roles in physiology and stress responses in plants...
  62. ncbi Sevelamer hydrochloride, a phosphate binder, protects against deterioration of renal function in rats with progressive chronic renal insufficiency
    Nobuo Nagano
    Pharmaceutical Development Laboratories, Kirin Brewery Co, Ltd, 3 Miyahara cho, Takasaki shi, Gunma 370 1295, Japan
    Nephrol Dial Transplant 18:2014-23. 2003
    ..This study examined whether sevelamer hydrochloride (Renagel(R); 'sevelamer' hereafter), a non-calcaemic phosphate binder could slow deterioration of renal function in rats with progressive renal insufficiency...
  63. pmc Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles
    Derek W Bartlett
    Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Bioconjug Chem 18:456-68. 2007
    ..The analysis of the CDP delivery vehicle provides insights that can be applied to the design of targeted nucleic acid delivery vehicles in general...
  64. ncbi Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase
    M Pietila
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    J Invest Dermatol 116:801-5. 2001
    ..Hair follicles were replaced by dermal cysts and epidermal utriculi. Analysis of skin polyamines revealed that the transgenic animals continuously overaccumulated putrescine...
  65. pmc Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
    John V W Becker
    CSIR Biosciences, PO Box 395, Pretoria, 0001, South Africa
    BMC Genomics 11:235. 2010
    ..falciparum spermidine synthase (PfSpdSyn) were examined on a morphological, transcriptomic, proteomic and metabolic level...
  66. ncbi The antizyme family: polyamines and beyond
    Ursula Mangold
    Program in Vascular Biology, Department of Surgery, Children s Hospital, Boston, MA 02115, USA
    IUBMB Life 57:671-6. 2005
  67. ncbi The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations
    D L Jack
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0116, USA
    Microbiology 146:1797-814. 2000
    ..Altogether, the APC superfamily probably includes 12 currently recognized families with members that exhibit exclusive specificity for amino acids and their derivatives but which can possess 10, 11, 12 or 14 TMSs per polypeptide chain...
  68. ncbi Dendrimers in biomedical applications--reflections on the field
    Sonke Svenson
    Dendritic NanoTechnologies, Inc, 2625 Denison Drive, Mount Pleasant, MI 48858, USA
    Adv Drug Deliv Rev 57:2106-29. 2005
    ..The reflections on biomedical applications of dendrimers given in this review clearly demonstrate the potential of this new fourth major class of polymer architecture and indeed substantiate the high hopes for the future of dendrimers...
  69. pmc Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3' untranslated region to HuR and AUF1
    Tongtong Zou
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Mol Cell Biol 30:5021-32. 2010
    b>Polyamines critically regulate all mammalian cell growth and proliferation by mechanisms such as the repression of growth-inhibitory proteins, including JunD...
  70. pmc Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines
    Xian Zhang
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21224, USA
    Nucleic Acids Res 37:7623-37. 2009
    ..Ectopic HuR overexpression or elevated cytoplasmic levels of endogenous HuR by decreasing cellular polyamines increased [HuR/XIAP mRNA] complexes, in turn promoting XIAP mRNA stability and increasing XIAP protein abundance...
  71. ncbi Phenolamides: bridging polyamines to the phenolic metabolism
    Jean Etienne Bassard
    Institute of Plant Molecular Biology, CNRS UPR 2357, University of Strasbourg, 28 rue Goethe, 67000 Strasbourg, France
    Phytochemistry 71:1808-24. 2010
    ..and quantitatively major group of secondary metabolites resulting from the conjugation of a phenolic moiety with polyamines or with deaminated aromatic aminoacids...
  72. pmc Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation
    Lan Liu
    Cell Biology Group, Department of Surgery, and Department of Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
    Mol Biol Cell 20:4885-98. 2009
    All mammalian cells depend on polyamines for normal growth and proliferation, but the exact roles of polyamines at the molecular level remain largely unknown...
  73. pmc Involvement of potD in Streptococcus pneumoniae polyamine transport and pathogenesis
    D Ware
    Mississippi Department of Health, Public Health Laboratory, 570 East Woodrow Wilson Drive, Jackson, MS 39216, USA
    Infect Immun 74:352-61. 2006
    b>Polyamines such as putrescine, spermidine, and cadaverine are small, polycationic molecules that are required for optimal growth in all cells...
  74. pmc Polyamines and abiotic stress tolerance in plants
    Sarvajeet Singh Gill
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Plant Signal Behav 5:26-33. 2010
    ..crop yields under adverse environmental stresses is probably the major challenge facing modern agriculture where polyamines can play important role...
  75. ncbi Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA
    Sebastien Spagnou
    IC Vec Ltd, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom
    Biochemistry 43:13348-56. 2004
    ..By contrast, LsiR particles formulated from lipofectAMINE2000 accumulate in fewer larger intracellular vesicles...
  76. ncbi NO signal at the crossroads: polyamine-induced nitric oxide synthesis in plants?
    Hideo Yamasaki
    Faculty of Science, University of the Ryukyus, Okinawa 903 0213, Japan
    Trends Plant Sci 11:522-4. 2006
    b>Polyamines, such as spermine, spermidine and putrescine, are ubiquitous polycationic compounds that are produced by almost all living organisms, including plants, animals, fungi and bacteria...
  77. ncbi Polyamine metabolism and cancer
    Thresia Thomas
    Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    J Cell Mol Med 7:113-26. 2003
    b>Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are intricately controlled by biosynthetic and catabolic enzymes...
  78. pmc Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis
    Panagiotis N Moschou
    Department of Biology, University of Crete, 71409 Heraklion, Greece
    Plant Physiol 147:1845-57. 2008
    ..The overall data reinforce the view that plants and mammals possess a similar PA oxidation system, concerning both the subcellular localization and the mode of its action...
  79. ncbi Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding
    J J Almrud
    Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA
    J Mol Biol 295:7-16. 2000
    The polyamines spermidine and spermine are ubiquitous and required for cell growth and differentiation in eukaryotes. Ornithine decarboxylase (ODC, EC 4.1.1...
  80. pmc Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis
    Markus Ketteler
    Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
    Clin J Am Soc Nephrol 3:1125-30. 2008
    ..This study investigated the ability of sevelamer carbonate to control serum phosphorous in hyperphosphatemic patients who had chronic kidney disease and were not on dialysis...
  81. ncbi Functions of amine oxidases in plant development and defence
    Alessandra Cona
    Dipartimento di Biologia, Universita degli Studi Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
    Trends Plant Sci 11:80-8. 2006
    Copper amine oxidases and flavin-containing amine oxidases catalyse the oxidative de-amination of polyamines, which are ubiquitous compounds essential for cell growth and proliferation...
  82. pmc An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae
    Jeongmi Lee
    Departments of Pharmacology, Microbiology, and Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 284:9899-907. 2009
    b>Polyamines are small organic cations found in all cells, and the biosynthetic pathway is well described in eukaryotes and Escherichia coli...
  83. ncbi Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy
    Suresh Mathew
    Renal Division, Department of Pediatrics, Washington University School of Medicien, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 18:122-30. 2007
    ..These results suggest that sevelamer may have important actions in decreasing diabetic and uremic vasculopathy and that sevelamer carbonate may be capable of increasing bone formation rates that are suppressed by diabetic nephropathy...
  84. pmc Effects of polyamines on the thermal stability and formation kinetics of DNA duplexes with abnormal structure
    M H Hou
    Institute of Chemistry, Academia Sinica, Taipei, 115 Taiwan
    Nucleic Acids Res 29:5121-8. 2001
    The effects of ions (i.e. Na+, Mg2+ and polyamines including spermidine and spermine) on the stability of various DNA oligonucleotides in solution were studied...
  85. ncbi In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis
    Dagmar Fischer
    Department of Pharmaceutics and Biopharmacy, University of Marburg, Ketzerbach 63, 35032, Marburg, Germany
    Biomaterials 24:1121-31. 2003
    ..fmk did not inhibit poly(ethylenimine)-induced cell damage. Insights into the structure-toxicity relationship are necessary to optimize the cytotoxicity and biocompatibility of non-viral gene delivery systems...
  86. ncbi Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer
    Naveen Babbar
    Arizona Cancer Center, and Biochemistry, Molecular and Cellular Biology Graduate Program, The University of Arizona, Tucson, 85724, USA
    J Biol Chem 278:47762-75. 2003
    ..These data suggest that apoptosis induced by sulindac sulfone is mediated, in part, by the COX-independent, PPAR-dependent transcriptional activation of SSAT, leading to reduced tissue polyamine contents in human colon cancer cells...
  87. ncbi Relative in vitro efficacy of the phosphate binders lanthanum carbonate and sevelamer hydrochloride
    Valerie Autissier
    School of Natural Sciences Chemistry, University of Newcastle, Newcastle upon Tyne, UK
    J Pharm Sci 96:2818-27. 2007
    ..These findings indicate that LC binds phosphate more effectively than SH across the pH range encountered in the gastrointestinal tract, and has a lower propensity for bound phosphate to be displaced by competing anions in the intestine...
  88. ncbi Positive charges of polyamines protect PSII in isolated thylakoid membranes during photoinhibitory conditions
    Saber Hamdani
    Groupe de Recherche en Biologie Végétale, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada G9A 5H7
    Plant Cell Physiol 52:866-73. 2011
    ..This protection was probably provided by the polycationic nature of SPM (four positive charges at physiological pH), which can stabilize surface-exposed proteins of PSII through electrostatic interaction...
  89. ncbi Enhanced susceptibility of photosynthesis to low-temperature photoinhibition due to interruption of chill-induced increase of S-adenosylmethionine decarboxylase activity in leaves of spinach (Spinacia oleracea L.)
    Lixiong He
    Department of Life Science, Faculty of Bioresources, Mie University, Tsu, 514 8507 Japan
    Plant Cell Physiol 43:196-206. 2002
    The possible involvement of polyamines in the chilling tolerance of spinach (Spinacia oleracea L.) was investigated focusing on photosynthesis...
  90. ncbi Lanthanum carbonate, like sevelamer-HCl, retards the progression of vascular calcification and atherosclerosis in uremic apolipoprotein E-deficient mice
    Igor G Nikolov
    INSERM ERI 12, UFR de Médecine Pharmacie, University of Picardie, Amiens, France
    Nephrol Dial Transplant 27:505-13. 2012
    ..We compared the effect of phosphate binder lanthanum (La) carbonate with sevelamer-HCl on atherosclerosis, VC and bone structure and function in mice with chronic renal failure (CRF)...
  91. ncbi Heterogeneous distribution of polyamines in temporal lobe epilepsy
    J Laschet
    Laboratory of Neurosciences, School of Medicine, University of Rennes, France
    Epilepsy Res 35:161-72. 1999
    ..The opposite was observed for spermine. The heterogeneous distribution of polyamines was compared to abnormal electrical activities recorded by SEEG: SPD/SPM index and spermidine levels were ..
  92. ncbi Self-assembly of highly phosphorylated silaffins and their function in biosilica morphogenesis
    Nils Kröger
    Lehrstuhl Biochemie I, Institut fur Biophysik und Physikalische Biochemie, Universitat Regensburg, 93053 Regensburg, Germany
    Science 298:584-6. 2002
    ..Time-resolved analysis of silica morphogenesis in vitro detected a plastic silaffin-silica phase, which may represent a building material for diatom biosilica...
  93. pmc Managing chronic inflammation in the aging diabetic patient with CKD by diet or sevelamer carbonate: a modern paradigm shift
    H Vlassara
    Division of Experimental Diabetes and Aging, Department of Geriatrics and Palliative Care, Mount Sinai School of Medicine, 1 Gustave Levy Place, NY 10029, USA
    J Gerontol A Biol Sci Med Sci 67:1410-6. 2012
    ..If larger and longer studies confirm the hypothesis that one or both of these interventions reduce progression of CKD, it could represent a new paradigm in the management of complications in the type 2 diabetes patient with CKD...
  94. pmc Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients
    Anibal Ferreira
    Nephrology Department, Hospital Curry Cabral, Lisboa, Portugal
    J Am Soc Nephrol 19:405-12. 2008
    ..Further studies are required to assess whether these changes affect clinical outcomes, such as rates of fracture...
  95. ncbi Determination of polyamine metabolome in plasma and urine by ultrahigh performance liquid chromatography-tandem mass spectrometry method: application to identify potential markers for human hepatic cancer
    Ran Liu
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Anal Chim Acta 791:36-45. 2013
    ..a UHPLC-MS/MS method has been developed and validated for simultaneous determination of polyamine precursors, polyamines, polyamine catabolite in human plasma and urine...
  96. ncbi A novel multidomain polyketide synthase is essential for zeamine production and the virulence of Dickeya zeae
    Jianuan Zhou
    Department of Plant Pathology, South China Agricultural University, Guangzhou 51642, People s Republich of China
    Mol Plant Microbe Interact 24:1156-64. 2011
    ..e., zeamine and zeamine II, that were phytotoxins and potent antibiotics. These results have established the essential role of ZmsA in zeamine biosynthesis and presented a new insight on the molecular mechanisms of D. zeae pathogenicity...
  97. pmc Interaction of brassinosteroids and polyamines enhances copper stress tolerance in raphanus sativus
    Sikander Pal Choudhary
    Department of Horticulture, Zhejiang University Hangzhou 310058, Zhejiang China
    J Exp Bot 63:5659-75. 2012
    Brassinosteroids (BRs) and polyamines (PAs) regulate various responses to abiotic stress, but their involvement in the regulation of copper (Cu) homeostasis in plants exposed to toxic levels of Cu is poorly understood...
  98. ncbi Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers
    Cheng Yiyun
    School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, People s Republic of China
    Eur J Med Chem 40:1188-92. 2005
    ..Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of NSAIDs...
  99. ncbi Targeting cancer cells with dendrimers
    Srinivasa Gopalan Sampathkumar
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Chem Biol 12:5-6. 2005
  100. ncbi Disruption of gene YlODC reveals absolute requirement of polyamines for mycelial development in Yarrowia lipolytica
    J F Jiménez-Bremont
    Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Gto, Mexico
    FEMS Yeast Res 1:195-204. 2001
    b>Polyamines are required for cellular growth and differentiation. In mammals and fungi they are synthesized via a pathway involving ornithine decarboxylase (ODC), which transforms ornithine into putrescine...
  101. pmc Enhancement of the synthesis of RpoE and StpA by polyamines at the level of translation in escherichia coli under heat shock conditions
    Yusuke Terui
    Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288 0025, Japan
    J Bacteriol 191:5348-57. 2009
    Proteins whose synthesis is enhanced by polyamines at the level of translation were identified with a polyamine-requiring mutant cultured in the presence of 0.1% glucose and 0.02% glutamate at 42 degrees C...

Research Grants70

  1. Epigenetic mechanisms relevant to the pathogenesis of ALS
    Neil W Kowall; Fiscal Year: 2013
    ..neuroprotective effect is not known but one possible mechanism may involve the production of neuroprotective polyamines that are potential substrates for LSD1, a key enzyme regulating protein methylation that shares considerable ..
  2. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..Since MYCN has been shown to activate ODC gene expression, we hypothesized that ODC and polyamines might play a role in MYCN-amplified NB tumorigenesis...
  3. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..AAMF selectively express arginases (isoforms I and II) to metabolize L-arginine into polyamines and proline, implicating AAMF as regulators of cellular proliferation and fibrosis during the wound healing ..
  4. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..acid transporter-2 (CAT2), is required for protein expression of iNOS and that its function is inhibited by polyamines in a process that restricts NO generation and leads to sustained bacterial colonization and inflammation...
    SHELLY CHI LOO LU; Fiscal Year: 2012
    ..provided by applicant): S-adenosylmethionine (SAMe) is the principal biological methyl donor, precursor for polyamines and glutathione (GSH). SAMe biosynthesis is catalyzed by methionine adenosyltransferase (MAT)...
  6. Regulation of Lung Fibrosis by Alternatively Activated Macrophages and Arginase-1
    ROBERT MATTHEW TIGHE; Fiscal Year: 2013
    ..Arginase-1 is responsible for the conversion of L-arginine to proline and polyamines. Polyamines are involved in cell proliferation while proline is a direct precursor of collagen...
  7. H. pylori induced DNA Damage and Immune Dysregulation
    Keith T Wilson; Fiscal Year: 2013
    ..pylori infection results in failure of antimicrobial and immunoregulatory NO generation and overproduction of polyamines and H2O2, leading to dysregulation of immune responses and survival of gastric epithelial cells with DNA damage...
    David J Feith; Fiscal Year: 2013
    ..Our long-term research goal is to understand the role of polyamines in the promotion and progression of epithelial cancers in order to develop novel prevention and treatment ..
  9. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..exhibit significantly increased sensitivity to modulation by a variety of endogenous agents, including protons, polyamines and zinc...
  10. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2013
    ..The parasite can also salvage host polyamines and their precursors via uptake mechanisms, one of which is the POT1 putrescine-spermidine transporter...
  11. Plague biofilm formation--regulation and function
    ROBERT DONALD PERRY; Fiscal Year: 2013
    ..b>Polyamines also play a role in the creation of a Y. pestis biofilm...
  12. Role of Polyamine Oxidase in Apoptosis Studies with RNA Interference
    GLENN KUEHN; Fiscal Year: 2009
    A voluminous literature documents studies that correlate the catabolism of the polyamines, spermidine and spermine, in plant and animal cells with the process of programmed cell death (apoptosis)...
  13. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2013
    ..that generates L-ornithine (L-Orn), which can be metabolized by either ornithine decarboxylase (ODC) to generate polyamines, or ornithine aminotransferase (OAT) to generate L-proline (L-Pro)...
  14. Encapsidation of the poxvirus genome
    Paula Traktman; Fiscal Year: 2012
    ..We are hypothesizing that the genome is condensed by association with polyamines, that I6 marks mature genomes for encapsidation by binding to their telomeres, and that subsequent interactions ..
  15. pH Regulation in Bacillus subtilis (AREA R15)
    JOAN SLONCZEWSKI; Fiscal Year: 2009
    ..pH-dependent metabolism in the gut generates acids as well as polyamines, permeant bases whose uptake promotes tumorigenesis...
  16. Epidermal stem cell properties in mice with altered polyamines
    Lisa M Shantz; Fiscal Year: 2010
    ..Information obtained from the proposed work will lead to future studies that address the broader question of what pathways are altered in follicular stem cells upon ODC downregulation. ..
  17. Preventing Human Prion Diseases - Inactivation of Prions
    Stanley B Prusiner; Fiscal Year: 2010
    ..Previous studies showed that prions become protease-sensitive after exposure to branched polyamines in the presence of a weak acid...
  18. Risk reduction through polyamine inhibition among colorectal carcinoma patients
    JASON ZELL; Fiscal Year: 2012
    ..RELEVANCE (See instructions): Polyamines are naturally occurring substances derived from arginine that, in excess, promote colon tumor formation...
  19. Engineering and Evaluation of Human L-Methionase for Cancer Therapy
    Everett Stone; Fiscal Year: 2013
    ..not only for protein synthesis but also as the precursor for methylation reductions and for the biosynthesis of polyamines. Tumors have a much greater requirement for L-Met than normal tissues and become apoptotic when its availability ..
  20. Polyamine-dependent regulation of Vibrio cholerae biofilm formation
    Ece Karatan; Fiscal Year: 2011
    ..cholerae. In this proposal, we focus our attention on a specific signaling system that responds to the polyamines norspermidine and spermidine...
  21. CNS Delivery of Activated Antiviral Drugs with Reduced Neurotoxicity (Nano-NRTIs)
    Serguei V Vinogradov; Fiscal Year: 2013
    ..Modification with brain receptor-specific peptides or polyamines is proposed in order to enhance the cooperativity of Nano-NRTI binding with the BBB following drug ..
  22. DNA - DNA interactions with atomic detail
    Lois Pollack; Fiscal Year: 2013
    ..from the spherical trivalen inorganic ion, cobalt hexa-amine, through the more rod-like, less charge-dense polyamines found in living cell;e.g., spermine and spermidine...
  23. Polyamine and trypanothione metabolism in Trypanosoma brucei
    Margaret A Phillips; Fiscal Year: 2013
    ..b>Polyamines are essential metabolites that are required for cell growth...
  24. Cellular Mapping of Small Molecule/Nucleic Acid Interactions
    Micah J Bodner; Fiscal Year: 2012
    ..b>Polyamines levels are elevated in neoplastic cells and polyamine biosynthesis is a target of chemotherapeutic agents, but ..
  25. Inhibiting Multiple Molecular Targets for Preventing Non-Melanoma Skin Cancer
    Mohammad Athar; Fiscal Year: 2013
    ..ODC is the rate limiting enzyme for synthesis of polyamines, which are essential for the growth and differentiation of all cells...
  26. Surgical Studies of Gut Permeability
    Jian Ying Wang; Fiscal Year: 2013
    ..intestinal epithelial paracellular permeability, and have identified a novel mechanism through which cellular polyamines regulate transcription of the genes encoding these intercellular junctional proteins...
  27. HMG-CoA Reductase and Polyamine Inhibitors for Prevention of Colorectal Cancer
    Chinthalapally V Rao; Fiscal Year: 2013
    ..Colon tumor cells produce high levels of polyamines endogenously through the activation of ornithine decarboxylase (ODC)...
  28. TAS::75 0849::TAS
    Wenlin Deng; Fiscal Year: 2011
    ..irreversible inhibitor of ornithine decarboxylase (ODC, the primary rate-limiting enzyme in the production of polyamines) significantly protects the gastrointestinal (GI) tract from whole-body radiation exposure...
  29. In vitro screening of novel therapeutic agents for the treatment of alcohol abuse
    S John Mihic; Fiscal Year: 2010
    ..b>polyamines, metals and benzodiazepines) there is a strong rationale to support the idea that small compounds can be ..
  30. Role of Arginase in Inflammation and Trauma
    SIDNEY MACHEN MORRIS; Fiscal Year: 2012
    ..The arginases are of particular interest because they can affect the synthesis not only of NO but also of polyamines and proline, which are essential for cell proliferation and collagen synthesis, respectively...
  31. Mechanisms controlling AMPA receptor subunit composition
    Steven J Tavalin; Fiscal Year: 2013
    ..including Ca2+ permeability, single channel conductance, receptor kinetics, and sensitivity to intracellular polyamines. Thus, alterations in subunit composition have a dramatic impact on the quality and strength of synaptic ..
  32. The Use of Polyamines in Treatment of Multidrug-Resistant Gram-Negative Pathogens
    Dong Hyeon Kwon; Fiscal Year: 2013
    ..PI discovered that exogenous polyamines (spermine, spermidine, and putrescine) in combination with 2-lactams sensitized 2- lactam resistance (become 4- ..
  33. Metallothioneins and polyamines in major depression and suicide
    Adolfo Sequeira; Fiscal Year: 2013
    ..observed specific gene expression alterations in two stress response molecular mechanisms, metallothioneins and polyamines, in brains of MDD suicide victims, with opposite effects however in MDD patients who died of other causes...
  34. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
    ..assess in flat and polypoid rectal-ileal mucosa markers of epithelial proliferation (ornithine decarboxylase, polyamines and immunohistochemistry for proliferating cell nuclear antigen), apoptosis (apoptotic index by morphologic ..
  35. Structure and Function of NMDA Receptors
    Hiroyasu Furukawa; Fiscal Year: 2013
    ..domain (S1S2) and are allosterically modulated by binding of modulator compounds including phenylethanolamines, polyamines, protons, and Zn2+ to the amino terminal domain (ATD)...
  36. Identification of transamidated proteins involved in cell death induction
    BASSAM M FRAIJ; Fiscal Year: 2012
    ..levels on induction of apoptosis independently of transamidation will be tested by a) specific TG inhibitors (polyamines, such as cystamine), b) antisense transfection and siRNA to block transglutaminase expression, and c) Site-..
  37. Integrin-mediated Regulation of Airway Smooth Muscle
    Dean Sheppard; Fiscal Year: 2013
    ..the enzyme spermine/spermidine acetyltransferase (SSAT), the rate limiting step in catabolism of higher order polyamines, and that this association and polyamine catabolism are important modulators of [unreadable]9[unreadable]1 ..
  38. Targeting S-adenosylmethionine decarboxylase for HAT drug discovery
    Margaret A Phillips; Fiscal Year: 2013
    ..b>Polyamines are essential metabolites that are required for cell growth...
  39. 2013 Polyamines Gordon Research Conference and Gordon Research Seminar
    John L Cleveland; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Polyamines Gordon Research Conference (GRC) has continuously run since 1975, where it provides a multidisciplinary forum that brings together top polyamine researchers as well as young and ..
  40. Role of Myelin in Spinal Cord Regeneration
    Marie T Filbin; Fiscal Year: 2013
    ..and one gen that is up-regulated is for the enzyme Arginase I (Arg I), which is key in the synthesis of polyamines. The polyamine, spermidine, can overcome inhibition by MAG in culture and promotes optic nerve regeneration in ..
    Ivan Rayment; Fiscal Year: 2013
    ..2. Polyamine Oxidase (PAO) is an amine oxidase that catalyzes the conversion of the acetylated polyamines, N1-acetylspermine and N1-acetylspermidine, back to their non-acetylated physiologically active forms...
  42. 7th Biennial Symposium on Polyamines in Parasites
    DESCRIPTION (provided by applicant): The 7th Biennial Symposium on Polyamines in Parasites will be held at Pacific University, Forest Grove, Oregon, on July 10-13, 2012...
  43. Colon Cancer Prevention with Phospho-Sulindac
    Basil Rigas; Fiscal Year: 2013
    ..key early mediators of the effect of chemopreventive agents, and on dependent signaling pathways including polyamines. 3) Determine in animal models of colon cancer (Min mice and xenografts) the effect of phosphosulindac plus DFMO ..
  44. Cellular Mechanisms of Retinopathy: Role of Arginase
    Ruth B Caldwell; Fiscal Year: 2013
    ..Arginase metabolizes L-arginine to form proline, polyamines and glutamate...
    Jenny J Yang; Fiscal Year: 2013
    ..NT) domain residues make to the formation of the cytoplasmic pore and its blockade by endogenous intracellular polyamines. Many of these loci have been associated with disease-causing connexin mutations such as oculodigitodental ..
  46. Validating novel drug targets in Trypanosoma cruzi polyamine biosynthesis
    Michael C Gretes; Fiscal Year: 2013
    ..2) evaluate the effects of these deletions by measuring levels of polyamines and trypanothione (a metabolite immediately downstream of polyamine pathway) as well as parasite growth rates in ..
  47. Univ of Maryland Baltimore Interdisciplinary Research Center in Benign Urology
    SUSAN F KEAY; Fiscal Year: 2011
    ..The three phenotypes of BUC that will be measured are expression of intracellular polyamines, expression of tight junction proteins, and cellular mechanosensitivity measured by adenosine triphosphate (ATP) ..
  48. Structure and Mechanism of a Virtual Proton Pump
    Christopher Miller; Fiscal Year: 2013
    ..APC proteins, nearly ubiquitous in the biological world, are used to move amino acids, polyamines, and a variey of organic cations across cell membranes for a multitude of physiological purposes...
  49. Staphylococcus aureus exploitation of autophagy promotes latent infection
    Alice S Prince; Fiscal Year: 2013
    ..have adapted to the conditions of oxidative stress within these cells and tolerate local concentrations of toxic polyamines. In the R21 phase of this project, we will fully characterize the intracellular compartment associated with SA ..
    YURIY KUCHERYAVYKH; Fiscal Year: 2013
    ..glioma cells express low levels of functional connexin (Cx) hemichannel/gap junction protein and high levels of polyamines (PA)...
  51. Hippocamppal neurotoxicity induced by ethanol withdrawal
    Mark A Prendergast; Fiscal Year: 2013
    ..neurotoxic effects of alcoholism, particularly during alcohol withdrawal, when excess release of glutamate and polyamines occurs...
  52. G-quadruplex in Translational Regulation and Cancer Therapy
    Hong Lu; Fiscal Year: 2013
    ..The working hypothesis is that TMPYP4, polyamines, and protoporphyrin IX inhibits, whereas certain G4 DNA oligos increase protein expression of these TFs in ..
  53. Intestinal Mucosal Growth in Health &Surgical Diseases
    Jian Ying Wang; Fiscal Year: 2013
    ..its target mRNAs encoding growth-regulatory proteins and its effect is regulated by given microRNAs and cellular polyamines. Three specific aims are proposed to test the hypothesis...
  54. Mucosal Repair in Gut Surgical Disorders
    Jian Ying Wang; Fiscal Year: 2012
    ..role in epithelial cell renewal during mucosal healing and have identified a novel mechanism through which polyamines modulate c-myc expression in critical surgical conditions...
  55. Calcium sensing receptor and scaffolds
    GERDA BREITWIESER; Fiscal Year: 2009
    ..calcium sensing receptor (CaR) transduces local changes in extracellular calcium and metabolites (anrtino acids, polyamines) into intracellular signals, which include acute alterations in cell metabolism and secretion, and long term ..
    RAO N JALADANKI; Fiscal Year: 2013
    ..also represses cell migration in cells overexpressing TRPC1;and c) Cav1 level is tightly regulated by cellular polyamines. Based on these exciting observations, we HYPOTHESIZE that Cav1 plays an important role in promoting gut ..
  57. Polyamines and Brain Signaling
    Serguei N Skatchkov; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The polyamines (PA), spermine (SPM) and spermidine (SPD), are reported to be neuroprotective and increase longevity...
  58. Novel Oligonucleotide Delivery Vehicles for Gene Tharapy
    TJ THOMAS; Fiscal Year: 2009
    ..The effects of polyamine analogues and ODNs on natural polyamines will be quantified by HPLC...
  59. The Effect of Single Nucleotide Polymorphisms on Protein Structure and Interactio
    EMIL GEORGIEV ALEXOV; Fiscal Year: 2010
    ..Specifically, in this proposal we focus on XLMR caused by a defect in spearmine synthase (SMS). Polyamines are ubiquitous molecules that interact with variety of other molecules in the cell and are essential for normal ..
  60. GI Hormones and Other Factors in Growth of Mucosa
    Leonard R Johnson; Fiscal Year: 2013
    ..This objective is unaltered in the current proposal, which focuses on elucidating the mechanism by which polyamines are required for apoptosis of intestinal epithelial cells...
    Murray Wittner; Fiscal Year: 2007
    ..we examined polyamine metabolism in the human pathogen Encephalitozoon cuniculi, and found the major natural polyamines putrescine, spermidine and spermine that are ubiquitous in cells and necessary for growth and division...
  62. Site-Selective Catalysis for Organic Synthesis
    Scott J Miller; Fiscal Year: 2013
    ..displacement reactions, deoxygenations, inter alia). Catalytic, site-selective amine functionalization within polyamines is virtually unknown, and we have initiated first steps for the development of these processes with a ..
  63. Aveolar Macrophage Apoptosis and Pneumocystis
    Chao Hung Lee; Fiscal Year: 2009
    ..BAL) fluids from animals with Pep are able to induce apoptosis in normal alveolar macrophages, and depletion of polyamines from these BAL fluids abrogates their ability to induce apoptosis...
  64. H.pylori arginase modulation of ulcers and cancer
    David McGee; Fiscal Year: 2007
    ..b>Polyamines (produced from ornithine) and arginase are elevated in the gastric mucosa of gastric cancer patients...
    Charles Henley; Fiscal Year: 1993
    ..Normal cell growth and differentiation require polyamines, concentrations of which are highly regulated by the enzyme ODC...
  66. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
    ..of Spermidine/Spermine N-1 acetyltransferase (SSAT), the rate limiting enzyme involved in the catabolism of polyamines, in IRI...
    JACK OLSON; Fiscal Year: 1999
    ..encoding sense or antisense RNA will increase or inhibit ODC activity sufficient to alter fibronectin, PCNA, polyamines, vascular structure and neovascularization in a manner similar to MCT, or if antisense will prevent these MCT-..
  68. Rational Design of Inhibitors of Polyamine Synthesis
    Steven Ealick; Fiscal Year: 2007
    ..b>Polyamines are ubiquitous cellular components and are necessary for normal cell growth...
    Eva Csuhai; Fiscal Year: 2000
    ..RD convertase is sensitive to inhibition by the polyamines spermine and spermidine...
  70. Improved Zwitterions for Proteomics
    LEO RODKEY; Fiscal Year: 2005
    ..Recent data show that simple hydration of the polyamines used to synthesize ampholytes can yield >95% pure linear forms of the molecules while eliminating branched ..