hydroxylamines

Summary

Summary: Organic compounds that contain the (-NH2OH) radical.

Top Publications

  1. ncbi A prodrug system for hydroxylamines based on esterase catalysis
    Ana Conejo-Garcia
    Department of Chemistry and Oxford Centre for Molecular Sciences, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK
    Bioorg Med Chem Lett 15:4004-9. 2005
  2. pmc Identification of sulfation sites of metabolites and prediction of the compounds' biological effects
    Lin Yi
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA
    Anal Bioanal Chem 386:666-74. 2006
  3. pmc Nitroxyl radical plus hydroxylamine pseudo self-exchange reactions: tunneling in hydrogen atom transfer
    Adam Wu
    Department of Chemistry, Campus Box 351700, University of Washington, Seattle, Washington 98195 1700, USA
    J Am Chem Soc 131:11985-97. 2009
  4. ncbi Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS
    Bernadett Kalmar
    Institute of Neurology, University College London, Queen Square, London, UK
    J Neurochem 107:339-50. 2008
  5. pmc X-linked gene transcription patterns in female and male in vivo, in vitro and cloned porcine individual blastocysts
    Chi Hun Park
    SooAm Biotech Research Foundation, Seoul, Republic of Korea
    PLoS ONE 7:e51398. 2012
  6. pmc EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines
    Sergey I Dikalov
    FRIMCORE, Emory University School of Medicine, Atlanta, GA, USA
    Free Radic Res 45:417-30. 2011
  7. pmc Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer
    Jianguo Zhao
    National Swine Resource and Research Center, Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Biol Reprod 81:525-30. 2009
  8. ncbi Scriptaid corrects gene expression of a few aberrantly reprogrammed transcripts in nuclear transfer pig blastocyst stage embryos
    Kristin M Whitworth
    Division of Animal Sciences, University of Missouri, E125 Animal Science Research Center, Columbia, USA
    Cell Reprogram 13:191-204. 2011
  9. ncbi Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 13:260-7. 2007
  10. pmc Plant cells oxidize hydroxylamines to NO
    Stefan Rümer
    Julius von Sachs Institut fur Biowissenschaften, Julius von Sachs Platz 2, D 97082 Wurzburg, Germany
    J Exp Bot 60:2065-72. 2009

Research Grants

  1. Nitogen reduction and xenobiotic response
    Lauren A Trepanier; Fiscal Year: 2010
  2. New Reactions for Direct, Native Peptide Ligations
    JEFFREY WILLIAM BODE; Fiscal Year: 2010
  3. SULFOTRANSFERASE INACTIVATION BY CARCINOGENS
    BONNIE MANGOLD; Fiscal Year: 1990
  4. NHLBI MINORITY INSTITUTION FACULTY MENTORED RESEARCH
    Harpal Singh; Fiscal Year: 2001
  5. Amine N-Oxygenation by FMO3 and FMO4
    John Cashman; Fiscal Year: 2005
  6. ELECTRON TRANSFER REACTIONS OF AMINO NITROGEN COMPOUNDS
    STEPHEN NELSEN; Fiscal Year: 1993
  7. CARCINOGEN ACTIVATION VIA ACYL TRANSFER
    PATRICK HANNA; Fiscal Year: 1980
  8. EARDA Transition: Further Enhance Faculty and Student R*
    Harpal Singh; Fiscal Year: 2005
  9. Honors Undergraduate Research Training at SSU
    Harpal Singh; Fiscal Year: 2006
  10. Comparative Glycomics of the HIV Protein gp 120
    Heather Desaire; Fiscal Year: 2009

Detail Information

Publications231 found, 100 shown here

  1. ncbi A prodrug system for hydroxylamines based on esterase catalysis
    Ana Conejo-Garcia
    Department of Chemistry and Oxford Centre for Molecular Sciences, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK
    Bioorg Med Chem Lett 15:4004-9. 2005
    ..Gamma-hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis...
  2. pmc Identification of sulfation sites of metabolites and prediction of the compounds' biological effects
    Lin Yi
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA
    Anal Bioanal Chem 386:666-74. 2006
    ..This work represents the first example of a high-throughput analysis that can identify the structure of sulfated metabolites and predict their biological effects...
  3. pmc Nitroxyl radical plus hydroxylamine pseudo self-exchange reactions: tunneling in hydrogen atom transfer
    Adam Wu
    Department of Chemistry, Campus Box 351700, University of Washington, Seattle, Washington 98195 1700, USA
    J Am Chem Soc 131:11985-97. 2009
    Bimolecular rate constants have been measured for reactions that involve hydrogen atom transfer (HAT) from hydroxylamines to nitroxyl radicals, using the stable radicals TEMPO(*) (2,2,6,6-tetramethylpiperidine-1-oxyl radical), 4-oxo-TEMPO(..
  4. ncbi Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS
    Bernadett Kalmar
    Institute of Neurology, University College London, Queen Square, London, UK
    J Neurochem 107:339-50. 2008
    ....
  5. pmc X-linked gene transcription patterns in female and male in vivo, in vitro and cloned porcine individual blastocysts
    Chi Hun Park
    SooAm Biotech Research Foundation, Seoul, Republic of Korea
    PLoS ONE 7:e51398. 2012
    ....
  6. pmc EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines
    Sergey I Dikalov
    FRIMCORE, Emory University School of Medicine, Atlanta, GA, USA
    Free Radic Res 45:417-30. 2011
    ..Cyclic hydroxylamines rapidly react with O₂ⁱ⁻, producing stable nitroxides and allowing site-specific cO₂ⁱ⁻ detection in ..
  7. pmc Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer
    Jianguo Zhao
    National Swine Resource and Research Center, Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Biol Reprod 81:525-30. 2009
    ..05). In conclusion, the extremely low cloning efficiency in the NIH miniature pig may be caused by its inbred genetic background and can be improved by alteration of genomic histone acetylation patterns...
  8. ncbi Scriptaid corrects gene expression of a few aberrantly reprogrammed transcripts in nuclear transfer pig blastocyst stage embryos
    Kristin M Whitworth
    Division of Animal Sciences, University of Missouri, E125 Animal Science Research Center, Columbia, USA
    Cell Reprogram 13:191-204. 2011
    ..0003). Scriptaid treatment significantly affected gene expression in 7 of the 14 transcripts evaluated and returned 3 genes to BLIVV levels...
  9. ncbi Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 13:260-7. 2007
    ....
  10. pmc Plant cells oxidize hydroxylamines to NO
    Stefan Rümer
    Julius von Sachs Institut fur Biowissenschaften, Julius von Sachs Platz 2, D 97082 Wurzburg, Germany
    J Exp Bot 60:2065-72. 2009
    ..Unexpectedly, the addition of superoxide dismutase (SOD) to cell suspensions stimulated NO formation from hydroxylamines, and SOD alone (without cells) also catalysed the production of NO from HA or SHAM...
  11. ncbi Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
    Dairin Kieran
    The Graham Watts Laboratory, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London WC1N 3BG, UK
    Nat Med 10:402-5. 2004
    ..Pharmacological activation of the heat shock response may therefore be a successful therapeutic approach to treating ALS, and possibly other neurodegenerative diseases...
  12. ncbi Neurotoxicity of reactive aldehydes: the concept of "aldehyde load" as demonstrated by neuroprotection with hydroxylamines
    Paul L Wood
    Department of Biomedical Engineering, The Falk Center for Molecular Therapeutics, McCormick School of Engineering and Applied Sciences, Northwestern University, 1801 Maple Avenue, Suite 4306, Evanston, IL 60201, USA
    Brain Res 1095:190-9. 2006
    ..To this end, we evaluated hydroxylamines as aldehyde-trapping agents in an in vitro model of neurodegeneration induced by the reactive aldehyde, 3-..
  13. pmc Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem
    Kelsey L Hanson
    Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
    Drug Metab Dispos 38:963-72. 2010
    ..S)-fluoxetine [(S)-FLX], and N-desmethyldiltiazem (MA) undergo N-hydroxylation to the corresponding secondary hydroxylamines [N-hydroxydesipramine, (S)-N-hydroxyfluoxetine, and N-hydroxy-N-desmethyldiltiazem] by cytochromes P450 2C11, ..
  14. ncbi N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro
    H Atamna
    Department of Molecular and Cell Biology, University of California, Berkeley/CHORI, Oakland, California 94609, USA
    FASEB J 15:2196-204. 2001
    ..NtBHA is an antioxidant that is recycled by mitochondrial electron transport chain and prevents radical-induced toxicity to mitochondria...
  15. ncbi 2,2,2-trifluoroethyl formate: a versatile and selective reagent for the formylation of alcohols, amines, and N-hydroxylamines
    David R Hill
    Abbott Laboratories, Global Pharmaceutical R and D, 1401 Sheridan Road, D R450, Bldg R8, North Chicago, Illinois 60064 4000, USA
    Org Lett 4:111-3. 2002
    reaction: see text] Treatment of a variety of alcohols, amines, and N-hydroxylamines with 2,2,2-trifluoroethyl formate gave the corresponding formylated adducts in high yields.
  16. pmc Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase
    J Y Lu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8593, USA
    Proc Natl Acad Sci U S A 93:10046-50. 1996
    ..These data support a role for palmitoyl-protein thioesterase in the lysosomal degradation of S-acylated proteins and define a major new pathway for the catabolism of acylated proteins in the lysosome...
  17. ncbi Kinetics and mechanism of hydroxyl radical and OH-adduct radical reactions with nitroxides and with their hydroxylamines
    Amram Samuni
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Chem Soc 124:8719-24. 2002
    ..Surprisingly, the reduced forms of cyclic nitroxides, cyclic hydroxylamines, are better reductants yet have no radioprotective activity...
  18. ncbi Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha
    Ling Yan
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Cancer Res 13:1532-9. 2007
    ..When located within topoisomerase IIalpha (topo II) cleavage sites in DNA, MX-AP sites act as dual lethal targets, not only functionally disrupting the base excision repair (BER) pathway but also potentially poisoning topo II...
  19. ncbi Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells
    Mikael Rinne
    Herman B Wells Center for Pediatric Research, 1044 West Walnut, Building R4, Room 302C, Indianapolis, IN 46202, USA
    Mol Cancer Ther 3:955-67. 2004
    ..These data establish transient MPG overexpression as a potential therapeutic approach for increasing cellular sensitivity to alkylating agent chemotherapy...
  20. ncbi Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization
    Pietro Taverna
    Department of Radiation Oncology and the Ireland Cancer Center, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106 4937, USA
    Cancer Res 63:838-46. 2003
    ..Thus, a genetic or biochemical impairment of BER results in increased IdUrd-induced cytotoxicity and radiosensitization in mammalian cells...
  21. ncbi Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis
    Merit E Cudkowicz
    Neurology Clinical Trials Unit, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Muscle Nerve 38:837-44. 2008
    ..Arimoclomol CSF levels increased with dose. Arimoclomol was shown to be safe, and it crosses the blood-brain barrier. Serum pharmacokinetic profiles support dosing of three times per day. An efficacy study in ALS is planned...
  22. ncbi Copper-catalyzed coupling of hydroxylamines with aryl iodides
    Kerri L Jones
    School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, United Kingdom
    Org Lett 10:797-800. 2008
    An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described...
  23. ncbi Palladium-catalyzed coupling of hydroxylamines with aryl bromides, chlorides, and iodides
    Achim Porzelle
    School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff CF10 3AT, UK
    Org Lett 11:233-6. 2009
    The bis-pyrazole phosphine ligand BippyPhos is effective for the palladium-catalyzed cross-coupling of hydroxylamines with aryl bromides, chlorides, and iodides...
  24. ncbi Base excision repair as a therapeutic target in colon cancer
    Lili Liu
    Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Cancer Res 8:2985-91. 2002
    ..DNA BER may be a useful pharmacological target through which tumor cells can be sensitized to alkylating therapeutic agents...
  25. ncbi Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage
    Sandhya Xavier
    Radiation Biology Branch, National Cancer Institute, Bldg 10, Room B3 B69, 9000 Rockville Pike, Bethesda, MD 20892 1002, USA
    Biochim Biophys Acta 1573:109-20. 2002
    ..damage using plasmid DNA, genomic DNA, and cell survival, by three nitroxides and their corresponding hydroxylamines, were examined...
  26. ncbi The products of the reduction of doxyl stearates in cells are hydroxylamines as shown by oxidation by 15N-perdeuterated Tempone
    K Chen
    Department of Physiology and Biophysics College of Medicine, University of Illinois, Urbana
    Biochim Biophys Acta 992:131-3. 1989
    ..paper presents data indicating the value of 15N-perdeuterated Tempone specifically to indicate the amount of hydroxylamines that are present in a cellular system...
  27. pmc Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione
    Andrey A Bobko
    Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Free Radic Biol Med 42:404-12. 2007
    ..The rapid reduction of NR in biological samples into hydroxylamines (HA) significantly limits their application...
  28. ncbi NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans
    Joseph R Kurian
    Department of Medical Sciences, University of Wisconsin Madison, School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, USA
    J Pharmacol Exp Ther 311:1171-8. 2004
    ..These results indicate a novel direct role for NADH cytochrome b5 reductase and cytochrome b5 in xenobiotic metabolism and suggest that pharmacogenetic variability in either of these proteins may effect drug reduction capacity...
  29. ncbi Aldehydic lipid peroxidation products derived from linoleic acid
    P Spiteller
    Lehrstuhl Organische Chemie I, , , 95440 Bayreuth, Germany
    Biochim Biophys Acta 1531:188-208. 2001
    ..Addition of m-chloroperbenzoic acid transforms 2,4-decadienal to 4-hydroxy-2-nonenal. 4,5-Epoxy-2-decenal, synthetically available by treatment of 2,4-decadienal with dimethyldioxirane, is hydrolyzed to 4,5-dihydroxy-2-decenal...
  30. ncbi Mild tagging procedures for the structural analysis of glycans
    S L Ramsay
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    Carbohydr Res 333:59-71. 2001
    ..Both procedures are suitable for the labeling of carbohydrates and oligosaccharide fragments from glycosaminoglycan structures, such as heparin and heparan sulfate...
  31. ncbi Mild and efficient Lewis acid-promoted detritylation in the synthesis of N-hydroxy amides: a concise synthesis of (-)-Cobactin T
    Shyh Ming Yang
    Johnson and Johnson Pharmaceutical Research and Development, L L C 8 Clarke Drive, Cranbury, New Jersey 08512, USA
    J Org Chem 72:8123-6. 2007
    ..An application of this methodology for a concise synthesis of (-)-Cobactin T (18) is also demonstrated...
  32. ncbi Catechol oxidase-like oxidation chemistry of the 1-20 and 1-16 fragments of Alzheimer's disease-related beta-amyloid peptide: their structure-activity correlation and the fate of hydrogen peroxide
    Giordano F Z da Silva
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, Tampa, Florida 33620 5250, USA
    J Biol Chem 280:16601-9. 2005
    ..The results presented here are expected to add further insight into the chemistry of metallo-Abeta, which may assist better understanding of the neuropathology of Alzheimer's disease...
  33. ncbi Electron spin resonance study of phosphorus-nitroxides from 1,3-additions of silicon-phosphorus reagents to nitrones
    D Lawrence Haire
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Magn Reson Chem 42:835-43. 2004
    ..Acidic hydrolysis provides the corresponding hydroxylamines that are easily oxidized to the title beta-phosphorus-nitroxides...
  34. ncbi Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
    Gang Ming Zou
    Department of Pediatrics Section of Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1917-22. 2007
    ..In summary, these data indicate Ape1 is required in normal embryonic hematopoiesis and that the redox function, but not the repair endonuclease activity, of Ape1 is critical in normal embryonic hematopoietic development...
  35. ncbi The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target
    Melissa L Fishel
    Department of Pediatrics Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Mol Aspects Med 28:375-95. 2007
    ..In this review, we will provide an overview of Ape1/Ref-1's activities and explore the potential of this protein as a target in cancer treatment as well as its role in chemoprevention...
  36. ncbi Sequential enzymatic oxidation of aminoarenes to nitroarenes via hydroxylamines
    Robert Winkler
    Leibniz Institute for Natural Products Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
    Angew Chem Int Ed Engl 44:4083-7. 2005
  37. ncbi Solvents inducing oxidation of hydroxylamines
    Shizuyo Horiyama
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 50:996-1000. 2002
    b>Hydroxylamines gradually undergo oxidation to their oximes on being dissolved in organic solvent (e.g. methanol). This phenomenon was followed by (1)H-NMR and liquid chromatography-mass spectrometry (LC-MS)...
  38. ncbi Molecular diversity of hydroxamic acids: part I. Solution- and solid-phase synthesis
    Kexin Yang
    Advanced SynTech, 9800 Bluegrass Parkway, Louisville, KY 40299, USA
    Mini Rev Med Chem 3:349-60. 2003
    ..This mini-review covers the most recent publications that highlight current strategies and syntheses of bioactive molecules containing the hydroxamate moiety in both solution- and solid-phase...
  39. ncbi Substituent effects on 15N NMR chemical shifts in selected N-alkylthiohydroxamic acids. A comparative study
    Witold Przychodzeń
    Faculty of Chemistry, Gdansk University of Technology, 80 952 Gdansk, Poland
    Magn Reson Chem 43:27-30. 2005
    ..acids (3) were measured and compared with appropriate spectra of structurally similar hydroxylamines (1), benzohydroxamic acids (4), benzamides (5) and thiobenzamides (6)...
  40. ncbi Kinetics and mechanism of the comproportionation reaction between oxoammonium cation and hydroxylamine derived from cyclic nitroxides
    Avner Israeli
    Department of Pharmaceutics, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
    Free Radic Biol Med 38:317-24. 2005
    ..From the pH dependence of the reaction rate constants we determined the pK(1) of the respective hydroxylamines to be 7.5 and 6.9, respectively...
  41. ncbi Hemolytic potential of structurally related aniline halogenated hydroxylamines
    Harpal Singh
    Department of Natural Sciences and Mathematics, College of Sciences and Technology, Savannah State University, Savannah, Georgia 31404, USA
    J Environ Pathol Toxicol Oncol 24:67-76. 2005
    ..The stability of some selected halogenated aniline analogs was also determined in blood. All four tested hydroxylamines produced dose-dependent reduction in the circulating labeled red blood cells indicating their destruction and ..
  42. ncbi 5'-(2-Nitrophenylalkanoyl)-2'-deoxy-5-fluorouridines as potential prodrugs of FUDR for reductive activation
    Bin Liu
    Department of Pharmaceutical Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Bioorg Med Chem 11:3889-99. 2003
    ..The fact that the amino intermediates cyclized easily to release the incorporated drug FUDR suggests the feasibility of using peptide-linked acyl 2-aminophenylalkanoic acid esters as potential prodrugs for proteolytic activation...
  43. ncbi The use of N-t-butyl hydroxylamine for radioprotection in cultured cells and mice
    Jin Hyup Lee
    Department of Biochemistry, College of Natural Sciences and College of Medicine, Kyungpook National University, Taegu 702 701, Korea
    Carcinogenesis 25:1435-42. 2004
    ..These data indicate that NtBHA may have great application potential as a new class of in vivo, non-sulfur containing radiation protector...
  44. ncbi Docking studies of nickel-peptide deformylase (PDF) inhibitors: exploring the new binding pockets
    Qiang Wang
    Institute of Theoretical Chemistry, Shandong University, Jinan 250100, China
    Biophys Chem 122:43-9. 2006
    ..Moreover, a new binding pocket is also explored. All these may provide something useful for designing the potent inhibitors...
  45. ncbi N-t-Butyl hydroxylamine regulates ionizing radiation-induced apoptosis in U937 cells
    Jin Hyup Lee
    School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Republic of Korea
    Biochimie 89:1509-16. 2007
    ..This study indicates that NtBHA may play an important role in regulating the apoptosis induced by ionizing radiation presumably through scavenging of reactive oxygen species...
  46. ncbi Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes
    A K Ho
    Department of Physiology, 7 26 Medical Sciences Building, Edmonton, Alberta, Canada
    Endocrinology 148:4592-600. 2007
    ..Moreover, both inhibitory and enhancing effects appear to be mediated through specific modification of promoter-bound histones during gene transcription...
  47. pmc Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy
    Yongli Kong
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Circulation 113:2579-88. 2006
    ..Thus, HDAC inhibitors hold promise as potential therapeutic agents in hypertrophic heart disease...
  48. ncbi Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid
    J Johnson
    Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, TX 75083, USA
    Cell Mol Biol (Noisy-le-grand) 51:229-38. 2005
    ..8-fold increase in gamma-globin mRNA transcripts. The potential for scriptaid as a treatment option for sickle cell disease will be discussed...
  49. ncbi Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro
    Jeannine S Strobl
    Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Blacksburg, Virginia 24060, USA
    J Parasitol 93:694-700. 2007
    ..gondii in our in vitro assays. We conclude that the hydroxamic acid class of histone deacetylase inhibitors exhibit potent anti-T. gondii activity in vitro...
  50. ncbi Reaction between N-alkylhydroxylamines and chiral enoate esters: more experimental evidence for a cycloaddition-like process, a rationale based on DFT theoretical calculations, and stereoselective synthesis of new enantiopure beta-amino acids
    Albertina G Moglioni
    Departament de Quimica, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Org Chem 67:2402-10. 2002
    ..As an application of these reactions, new beta-amino acids have been synthesized in a highly efficient and stereocontrolled manner...
  51. ncbi Combinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors
    Ahmed El Zoeiby
    Centre de Recherche sur la Fonction, Structure et Ingénierie des Protéines, Faculte de Medecine, Pavillon Charles Eugène Marchand, Universite Laval, Sainte Foy, Quebec, G1K 7P4, Canada
    Bioorg Med Chem 11:1583-92. 2003
    ..This approach yielded interesting lead compounds for the development of novel antibacterial agents...
  52. pmc Induction of human gamma globin gene expression by histone deacetylase inhibitors
    Hua Cao
    Medical Genetics, Box 357720, University of Washington, Seattle, WA 98195, USA
    Blood 103:701-9. 2004
    ....
  53. ncbi [Ring cleavage of N-arylpyridinium salts by nucleophiles--regioselectivity and stereochemistry of the products. 2]
    H Möhrle
    Institut fur Pharmazeutische Chemie, Heinrich Heine Universitat, Dusseldorf, Germany
    Pharmazie 56:448-57. 2001
    ..This is proved by dehydration to uniform nitriles and the synthesis from the corresponding aldehydes by oximation...
  54. ncbi Escherichia coli glycerol kinase: role of a tetramer interface in regulation by fructose 1,6-bisphosphate and phosphotransferase system regulatory protein IIIglc
    W Z Liu
    Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128
    Biochemistry 33:10120-6. 1994
    ..abstract truncated at 250 words)..
  55. ncbi In situ preparation of beta-D-1-O-hydroxylamino carbohydrate polymers mediated by galactose oxidase
    Peter R Andreana
    Department of Chemistry, Wayne State University, Detroit, Michigan 48202 3489, USA
    Org Lett 4:1863-6. 2002
    reaction: see text] Galactose oxidase produced a C-6 aldehyde in various terminal-containing galactose hydroxylamines for the simultaneous in situ generation of an A-B type condensation for the construction of unique oxime polymers...
  56. ncbi Kinetics and mechanism of peroxyl radical reactions with nitroxides
    Sara Goldstein
    Department of Physical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Phys Chem A 111:1066-72. 2007
    ..The results demonstrate a clear correlation between the kinetic features of the nitroxides and their ability to inhibit biological damage inflicted by peroxyl radicals...
  57. ncbi NMR spin trapping: detection of free radical reactions with a new fluorinated DMPO analog
    V V Khramtsov
    Dorothy M. Davis Heart and Lung Research Institute, Department of Internal Medicine, Pulmonary and Critical Care Medicine, Ohio State University, Columbus, OH, USA
    Free Radic Biol Med 30:1099-107. 2001
    ..CH(2)OH. In each case, these peaks were assigned to the two stereoisomers of their respective, reduced hydroxylamines. The identification of the hydroxylamines for FDMPO/ ...
  58. ncbi Hydrogen abstraction ability of different aromatic nitroxides
    Elisabetta Damiani
    Dipartimento di Scienze dei Materiali e della Terra, Universita Politecnica delle Marche, Via Brecce Bianchi, I 60131 Ancona, Italy
    Free Radic Res 38:67-72. 2004
    ....
  59. ncbi Formation of TEMPOL-hydroxylamine during reaction between TEMPOL and hydroxyl radical: HPLC/ECD study
    Wataru Kudo
    Department REDOX Medicinal Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Free Radic Res 42:505-12. 2008
    ..Finally, it was clarified that TEMPOL-H was generated during dopamine metabolism, which is believed to be one of the (*)OH sources in pathological processes such as Parkinson's disease...
  60. ncbi UV-induced free radicals in the skin detected by ESR spectroscopy and imaging using nitroxides
    T Herrling
    Privatinstitut Galenus GmbH, Volmerstrasse 7A, D 12489 Berlin, Germany
    Free Radic Biol Med 35:59-67. 2003
    ..This reduction was shown to be caused mainly by UVA radiation (320-400 nm)...
  61. ncbi Detection and removal of contaminating hydroxylamines from the spin trap DEPMPO, and re-evaluation of its use to indicate nitrone radical cation formation and S(N)1 reactions
    Simon K Jackson
    Department of Medical Microbiology, University of Wales College of Medicine, Cardiff, Wales, UK
    Free Radic Biol Med 32:228-32. 2002
    ..As a result, techniques for the detection and elimination of such hydroxylamine impurities from DEPMPO solutions were developed and are described; these should prove to be of general use in EPR spin trapping experiments...
  62. ncbi Acyl-protected hydroxylamines as spin label generators for EPR brain imaging
    Alexander T Yordanov
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 45:2283-8. 2002
    ..paramagnetic resonance (EPR) brain imaging agents, we have designed and synthesized the acyl-protected hydroxylamines 1-acetoxy-4-methoxycarbonyl-2,2,6,6-tetramethylpiperidine (AMCPe), 1-acetoxy-3-methoxycarbonyl-2,2,5,5-..
  63. ncbi Bovine erythrocyte superoxide dismutase. Complete amino acid sequence
    H M Steinman
    J Biol Chem 249:7326-38. 1974
  64. ncbi Two mechanisms for toxic effects of hydroxylamines in human erythrocytes: involvement of free radicals and risk of potentiation
    C T Evelo
    Department of Pharmacology, Universiteit Maastricht, The Netherlands
    Blood Cells Mol Dis 24:280-95. 1998
    The toxic potency of three industrially used hydroxylamines was studied in human blood cells in vitro. The parent compound hydroxylamine and the O-ethyl derivative gave very similar results...
  65. ncbi Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties
    Kyung Mi Kim
    Department of Chemistry, Yonsei University, 120 749, Seoul, South Korea
    Bioorg Med Chem Lett 13:2273-5. 2003
    ....
  66. ncbi Malyl-CoA formation in the NAD-, CoASH-, and alpha-ketoglutarate dehydrogenase-dependent oxidation of 2-keto-4-hydroxyglutarate. Possible coupled role of this reaction with 2-keto-4-hydroxyglutarate aldolase activity in a pyruvate-catalyzed cyclic oxidati
    S C Gupta
    J Biol Chem 259:10012-9. 1984
    ..coli is coupled with the oxidative decarboxylation of this substrate, as reported here, and other enzymes in a multistep pyruvate-catalyzed cyclic oxidation of glyoxylate...
  67. ncbi Spectrophotometric method for the determination of nifedipine with 4-(methylamino)phenol and potassium dichromate
    Nafisur Rahman
    Department of Chemistry, Aligarh Muslim University, India
    Farmaco 57:435-41. 2002
    ..9 x 10(3) l mol(-1) cm(-1), 1.1 microg ml(-1), 99.7-100.5% and 0.3-0.8%, respectively. The proposed method was compared favourably with the official B.P. method...
  68. ncbi Thermodynamic analysis of the binding of aromatic hydroxamic acid analogues to ferric horseradish peroxidase
    S M Aitken
    Department of Chemistry and Biochemistry, Concordia University, 1455 de Maisonneuve Boulevard West, Montreal, Quebec, Canada
    Biochemistry 40:13980-9. 2001
    ..Examination of the thermodynamics of binding of ring-substituted hyrazides to HRPC reveals that the binding affinities of aromatic donors are highly sensitive to the position and nature of the ring substituent...
  69. ncbi Effect of hydroxylamine on photosystem II: reinvestigation of electron paramagnetic resonance characteristics reveals possible S state intermediates
    Jonathan H A Nugent
    Department of Biology, Darwin Building, University College London, UK
    Biochemistry 42:5500-7. 2003
    ..The evidence is presented that they do represent intermediate states in S state turnover. Further work is now needed to identify these radicals...
  70. ncbi Analysis of 3'-phosphoglycolaldehyde residues in oxidized DNA by gas chromatography/negative chemical ionization/mass spectrometry
    Christiane Collins
    Biological Engineering Division, NE47 277, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 16:1560-6. 2003
    ....
  71. ncbi The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 8:1363-71. 2006
    ..In this review, we discuss the biochemistry of such reactions in the context of their pharmacologic and biologic implications...
  72. pmc Attachment site(s) of retinal in bacteriorhodopsin
    N V Katre
    Proc Natl Acad Sci U S A 78:4068-72. 1981
    ..This last point severely limits the possible arrangements of the amino acid sequence in the bacteriorhodopsin tertiary structure and clearly distinguishes two models that are consistent with all criteria...
  73. pmc Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5
    Joseph R Kurian
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706 1102, USA
    Chem Res Toxicol 19:1366-73. 2006
    ..We found that reduction of the carcinogenic hydroxylamines of the aromatic amine 4-aminobiphenyl (4-ABP; found in cigarette smoke) and the heterocyclic amine 2-amino-1-..
  74. ncbi Aromatic substrate specificity of horseradish peroxidase C studied by a combined fluorescence line narrowing/energy minimization approach: the effect of localized side-chain reorganization
    M LaBerge
    Institute of Biophysics and Radiation Biology, Semmelweis University, Puskin u. 9, Hungary H-1088
    Biochemistry 40:9226-37. 2001
    ....
  75. ncbi Arraying glycomics: a novel bi-functional spacer for one-step microscale derivatization of free reducing glycans
    Ognian Bohorov
    Glycan Array Synthesis Core D, Consortium for Functional Glycomics, Department of Molecular Biology, The Scripps Research Institute, CB 248A 10550 N, Torrey Pines Road, La Jolla, CA 92037, USA
    Glycobiology 16:21C-27C. 2006
    ..Our study results revealed that glycans conjugated with this bi-functional linker were effectively printed and detected with various lectins and antibodies...
  76. ncbi Transition metal coordination chemistry ofN,N-bis(2-{pyrid-2-ylethyl})hydroxylamine
    Christopher W Belock
    Department of Chemistry, Knight Chemical Laboratory, University of Akron, Akron, Ohio 44325 3601, USA
    Inorg Chem 47:7114-20. 2008
    ..mediated biological nitrification as well as the coordination chemistry of peroxide, the metal complexes of hydroxylamines and their functionalized variants remain largely unexplored...
  77. ncbi Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes
    Bernd Clement
    Pharmazeutisches Institut, Christian Albrechts Universitat, Gutenbergstr 76, D 24118 Kiel, Germany
    Life Sci 77:205-19. 2005
    ..25 +/- 0.15 nmol DDS/min/mg protein. Cytochrome b5, NADH-cytochrome b5 reductase are therefore involved in the detoxification of these reactive hydroxylamines and CYP2D increased the N-reduction.
  78. ncbi Decomposition of energetic chemicals contaminated with iron or stainless steel
    Sima Chervin
    Eastman Kodak Company, Rochester, NY 14652 6270, USA
    J Hazard Mater 130:48-52. 2006
    ..The following classes of energetic chemicals were investigated: nitrobenzenes, tetrazoles, hydrazines, hydroxylamines and oximes, sulfonic acid derivatives and monomers...
  79. ncbi Anti-inflammatory and anti-allergic activities of hydroxylamine and related compounds
    Hiromi Kataoka
    School of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Biol Pharm Bull 25:1436-41. 2002
    ..ethane (M-HA) were synthesized from the corresponding oximes with sodium cyanoborohydride, and N,O-diacetyl hydroxylamines (P-HA-Ac and M-HA-Ac) were prepared from these hydroxylamines using acetyl chloride...
  80. ncbi Hemoglobin binding of bicyclic aromatic amines
    G Sabbioni
    Walther Straub Institut für Pharmakologie und Toxikologie, Ludwig Maximilians Universitat Munchen, Nussbaumstrasse 26, D 80336 MUnchen, Germany
    Chem Res Toxicol 11:471-83. 1998
    ..We investigated the biological availability of the N-hydroxylamines of ortho-substituted diamines and of known carcinogenic diamines in female Wistar rats, by determining ..
  81. ncbi Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonance
    S Dikalov
    Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia
    Nitric Oxide 1:423-31. 1997
    The reactions of two hydroxylamines, 1-hydroxy-3-carboxy-pyrrolidine (CP-H) and 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine (TEMPONE-H), with superoxide radicals and peroxynitrite were studied...
  82. ncbi Peculiar properties of photoinduced hydroxylaminolysis in different bacteriorhodopsin-based media using O-substituted hydroxylamines
    Tatyana V Dyukova
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
    Photochem Photobiol 86:1255-8. 2010
    ..hydroxylaminolysis has been re-examined in different bacteriorhodopsin (BR)-based media using O-substituted hydroxylamines, in particular, O-(4-nitrobenzyl) hydroxylamine hydrochloride (NBHA), O-(2,3,4,5,6-pentafluorobenzyl) ..
  83. ncbi Discovery and characterization of a cytochrome b5 variant in humans with impaired hydroxylamine reduction capacity
    Joseph R Kurian
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Pharmacogenet Genomics 17:597-603. 2007
    ..We hypothesized that functionally significant genetic variability in cyt b5 could be found in healthy individuals...
  84. ncbi Conversion of the 2,2,6,6-tetramethylpiperidine moiety to a 2,2-dimethylpyrrolidine by cytochrome P450: evidence for a mechanism involving nitroxide radicals and heme iron
    Wenji Yin
    Department of Drug Metabolism, Merck Research Laboratories, P O Box 2000, Rahway, New Jersey 07065, USA
    Biochemistry 43:5455-66. 2004
    ..Dispos. 31, 215-223]. In the current report, evidence is provided for the involvement of 2,2,6,6-TMPi hydroxylamines and their one-electron oxidation products, the nitroxide radicals, as intermediates in this pathway...
  85. ncbi Covalent interaction of 5-nitroimidazoles with DNA and protein in vitro: mechanism of reductive activation
    G L Kedderis
    Department of Animal Drug Metabolism, Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065
    Chem Res Toxicol 2:146-9. 1989
    ..These results suggest that the reductive activation of 5-nitroimidazoles generally proceeds via four-electron reduction to form hydroxylamines followed by nucleophilic attack at C4.
  86. ncbi The novel ketoprofen amides--synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents
    Zrinka Rajic
    Department of Medicinal Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, HR 10000 Zagreb, Croatia
    Chem Biol Drug Des 75:641-52. 2010
    ..amides of ketoprofen and its reduced derivatives (5a-f, 4a-n, 6a-g) with aromatic and cycloalkyl amines or hydroxylamines were prepared and screened for their reducing and cytostatic activity as well as for their ability to inhibit ..
  87. ncbi Regio- and stereoselectivity in the decatungstate photocatalyzed alkylation of alkenes by alkylcyclohexanes
    Daniele Dondi
    Department of General Chemistry v Taramelli 12, 27100 Pavia, Italy
    Chemistry 15:7949-57. 2009
    ..trapping by the nitroxide TEMPO (TEMPO = 2,2,6,6-tetramethylpiperidine N-oxide) gives O-(tert-butylcyclohexyl)hydroxylamines, again as only the 3- and the 4-substituted isomers...
  88. ncbi Synthesis of small glycopeptides by decarboxylative condensation and insight into the reaction mechanism
    Aditya K Sanki
    Department of Chemistry, The University of Toledo, 2801 W Bancroft Street, Toledo, Ohio 43606, USA
    J Org Chem 74:1886-96. 2009
    ..to the expected tripeptide product, 2,5-substituted oxazoles were isolated when O-tert-butyl protected N-hydroxylamines of glycine were employed in the reaction...
  89. ncbi Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases
    Alexia Chandor
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université R Descartes, UMR 8601 CNRS, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Chem Res Toxicol 21:836-43. 2008
    ..CB1954) is a dinitroaromatic compound tested as an antitumor prodrug that requires reduction to the 2- and 4-hydroxylamines to be cytotoxic. Here, we studied the interaction of neuronal, inducible, and endothelial NOSs with CB1954...
  90. ncbi On the distinction between nitroxyl and nitric oxide using nitronyl nitroxides
    Uri Samuni
    Department of Chemistry and Biochemistry, Queens College, City University of New York, Flushing, New York 11367, USA
    J Am Chem Soc 132:8428-32. 2010
    ..HNO readily reacts with nitronyl nitroxides, leading to the formation of the respective imino nitroxides and hydroxylamines via a complex mechanism...
  91. pmc Pathways for intracellular generation of oxidants and tyrosine nitration by a macrophage cell line
    Amy M Palazzolo-Ballance
    Department of Chemistry, Washington State University, Pullman, Washington 99164 4630, USA
    Biochemistry 46:7536-48. 2007
    ..cell, as was demonstrated by using phagocytosable dichlorodihydrofluorescein-conjugated latex beads and cyclic hydroxylamines with differing membrane permeabilities...
  92. ncbi Mode of action of poly(vinylpyridine-N-oxide) in preventing silicosis: effective scavenging of carbonate anion radical
    Sara Goldstein
    Department of Physical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Chem Res Toxicol 19:86-91. 2006
    ..physiological pH have abstractable hydrogen atoms and are expected to react rapidly with CO3*-, just as cyclic hydroxylamines do. It is also shown that PVPNO inhibits tyrosine nitration by peroxynitrite at pH 7...
  93. pmc Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide
    M C Krishna
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:5537-41. 1992
    ..O2- and reducing agents such as NADH and NADPH, the nitroxides underwent reduction to their respective hydroxylamines. The reaction of 4-hydroxy-2,2,6,6-tetramethyl-1-hydroxypiperidine (Tempol-H) with ...
  94. ncbi DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
    I L Steffensen
    Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway
    Pharmacol Toxicol 86:257-63. 2000
    ..3.1.5) activate carcinogenic heterocyclic amines found in the crust of fried meat via O-acetylation of their N-hydroxylamines to reactive intermediates that bind covalently to DNA and produce mutations...
  95. pmc 2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT
    N A Helsby
    Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Br J Cancer 90:1084-92. 2004
    ..four cytotoxic extracellular metabolites of CB 1954 in cultures of NTR-expressing tumour cells (the 2- and 4-hydroxylamines and their corresponding amines)...
  96. ncbi Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines. XI. Peroxygenase versus monooxygenase function of cytochrome P-450 in rat liver microsomes
    K H Jönsson
    Department of Organic Pharmaceutical Chemistry, Uppsala University, Sweden
    Chem Biol Interact 75:267-79. 1990
    ..With the hydroxylamines the ability to form complexes was greater than with any of the amines but no definite difference was seen ..
  97. ncbi Reaction of cyclic nitroxides with nitrogen dioxide: the intermediacy of the oxoammonium cations
    Sara Goldstein
    Department of Physical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Am Chem Soc 125:8364-70. 2003
    ..NO2 and are close to that of the reaction of .NO2 with .NO, that is, 1.1 x 10(9) M(-1) s(-1). The hydroxylamines TPO-H and 4-OH-TPO-H are less reactive toward ...
  98. pmc Influence of hydroxylamine conformation on stereocontrol in Pd-catalyzed isoxazolidine-forming reactions
    Georgia S Lemen
    Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109 1055, USA
    J Org Chem 74:2533-40. 2009
    ..the stereocontrol in the C-N bond-forming Pd-catalyzed carboamination reactions of N-Boc-O-(but-3-enyl)hydroxylamines is significantly higher than that of related C-O bond-forming carboetherification reactions of N-benzyl-N-(but-..
  99. ncbi Reactions of nitric oxide, peroxynitrite, and carbonate radicals with nitroxides and their corresponding oxoammonium cations
    Sara Goldstein
    Department of Physical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Chem Res Toxicol 17:250-7. 2004
    ..M(-1) s(-1), which are about 3-4 times higher than those determined for H-abstraction from the corresponding hydroxylamines TPO-H and 4-OH-TPO-H...
  100. ncbi The effect of acetylation and deacetylation on the disposition of dapsone and monoacetyl dapsone hydroxylamines in human erythrocytes in-vitro
    M D Coleman
    Department of Pharmaceutical Sciences, Aston University, Birmingham, UK
    J Pharm Pharmacol 48:401-6. 1996
    ..Within the erythrocytes, both dapsone and monoacetyl hydroxylamines were found to undergo acetylation, deacetylation and diacetylation...
  101. ncbi Modulation of oxidative damage by nitroxide free radicals
    Ileana Dragutan
    Institute of Organic Chemistry, Romanian Academy P O B 35 108, Bucharest, 060023 Romania
    Free Radic Res 41:303-15. 2007
    ..In biological environments, they undergo mostly reduction to stable hydroxylamines but can also undergo oxidation to reactive oxoammonium compounds...

Research Grants28

  1. Nitogen reduction and xenobiotic response
    Lauren A Trepanier; Fiscal Year: 2010
    ..b>Hydroxylamines spontaneously oxidize to reactive nitroso metabolites, which, in the case of SMX, can trigger delayed-type ..
  2. New Reactions for Direct, Native Peptide Ligations
    JEFFREY WILLIAM BODE; Fiscal Year: 2010
    ..of fragments containing the requisite functional groups, namely C-terminal alpha-ketoacids and N-terminal hydroxylamines. The ketoacids are prepared by a mild two step protocol based on a new solid phase linker...
  3. SULFOTRANSFERASE INACTIVATION BY CARCINOGENS
    BONNIE MANGOLD; Fiscal Year: 1990
    ..it also participates in the bioactivation of several types of chemical carcinogens including safrole, aromatic hydroxylamines and hydroxamic acids, and hydroxyxanthines...
  4. NHLBI MINORITY INSTITUTION FACULTY MENTORED RESEARCH
    Harpal Singh; Fiscal Year: 2001
    ..Specifically, a series of structurally related aryl hydroxylamines (selected on the basis of varying arylhydronitroxide stability), will be compared with respect to aryl ..
  5. Amine N-Oxygenation by FMO3 and FMO4
    John Cashman; Fiscal Year: 2005
    ..The overall goal of our work is to understand the details of FMO-mediated N-oxygenation of amines and hydroxylamines. Accumulation of hydroxylamines in the CNS may lead to cytotoxicity or apoptosis...
  6. ELECTRON TRANSFER REACTIONS OF AMINO NITROGEN COMPOUNDS
    STEPHEN NELSEN; Fiscal Year: 1993
    ..Acylated hydroxylamines and diacylhydrazines provide compounds of intermediate importance of geometry reorganization, which will allow ..
  7. CARCINOGEN ACTIVATION VIA ACYL TRANSFER
    PATRICK HANNA; Fiscal Year: 1980
    ..other than N-arylacetohydroxamic acids can serve as acyl donors in the metabolic conversion of aromatic hydroxylamines to N-acyloxyarylamines...
  8. EARDA Transition: Further Enhance Faculty and Student R*
    Harpal Singh; Fiscal Year: 2005
    ..The administration enthusiastically supports, and is committed to the continuation of research development capability of faculty and students when EARDA funding concludes. ..
  9. Honors Undergraduate Research Training at SSU
    Harpal Singh; Fiscal Year: 2006
    ..A mandatory Bioethics course is proposed for MARC participants. The SSU MARC program is a concerted approach to enlarge the pool of minority biomedical scientists. ..
  10. Comparative Glycomics of the HIV Protein gp 120
    Heather Desaire; Fiscal Year: 2009
    ..Collaborators on the project include Dr. George Bousfield, a glycobiologist from Wichita State University, and Drs. Mike Alterman and Todd Williams, Co-Directors of the University of Kansas Proteomics Facility. ..
  11. DOUBLE BLIND STUDY OF MINOCYCLINE IN HD
    Merit Cudkowicz; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  12. Structural Basis for Sporulation in Bacillus
    Seth A Darst; Fiscal Year: 2010
    ..4. Structurally characterize the ?F regulatory system (?F/SpollAA/SpollAB/SpollE) controlling the initiation of Bacillus sporulation. ..
  13. Structure/Function of the Bacterial TRCF
    Seth Darst; Fiscal Year: 2008
    ..3. Determine the structural basis for the specific transcription termination activity of TRCF through structural studies of an RNAP ternary elongation complex (RNAP/DNA/RNA) with TRCF. ..
  14. TGF-beta 1-regulated IL-8 expression in prostate cancer
    Zhongyun Dong; Fiscal Year: 2007
    ..TGF-beta1-stimulated IL-8 expression and IL-8 gene promoter activation in cells lacking the three TGF-beta signaling pathways as well as transcription factors involved will be determined. ..
  15. Coenzyme Q10 in Huntington's Disease
    Merit Cudkowicz; Fiscal Year: 2007
    ..abstract_text> ..
  16. X-RAY CRYSTALLOGRAPHIC STUDIES OF TAQ RNA POLYMERASE
    Seth Darst; Fiscal Year: 2008
    ..Determine the crystal structure of RNAP with the transcription elongation factor GreA/B; 5. Determine the crystal structure of T. thermophilus sigma (E) holoenzyme. ..
  17. Upgrade of in-house X-ray diffraction equipment
    Seth Darst; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  18. STRUCTURAL PARAMETERS OF E COLI RNA POLYMERASE
    Seth Darst; Fiscal Year: 2001
    ....
  19. HPLC DETECTION OF RADICAL INTERMEDIATES
    Detcho Stoyanovsky; Fiscal Year: 2002
    ..that a major metabolic transformation of the nitroxides is their reduction to the corresponding ESR-silent hydroxylamines. The proposed combination of the ESR spin trapping and EC-HPLC techniques may overcome this experimental ..
  20. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2002
    ....
  21. CHEMISTRY AND BIOLOGY OF INSULIN-LIKE VANADIUM COMPOUNDS
    DEBBIE CRANS; Fiscal Year: 2003
    ..The proposed studies will lead to an in-depth understanding of both the chemical and pharmacological properties of known and new vanadium compounds inducing insulin-like action. ..
  22. CLINICAL TRIAL OF TOPIRAMATE IN ALS
    Merit Cudkowicz; Fiscal Year: 2003
    ..Secondary outcome measures include grip strength, forced vital capacity, the ALS functional rating scale, and the safety and tolerability of topiramate in this population. ..
  23. Clinical Trial of Ceftriaxone in ALS
    Merit Cudkowicz; Fiscal Year: 2004
    ..Secondary outcome measures will include ALSFRS-R, vital capacity, strength, and the long-term safety and tolerability of ceftriaxone in this population. ..
  24. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 2010
    ..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
  25. Xenobiotics, Lipid Peroxidation and Autoimmunity
    M Firoze Khan; Fiscal Year: 2006
    ..abstract_text> ..
  26. Metabolomic Signatures in ALS
    Merit Cudkowicz; Fiscal Year: 2005
    ..abstract_text> ..
  27. Novel therapeutics for chronic pain
    Paul Wood; Fiscal Year: 2005
    ....