methamphetamine

Summary

Summary: A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.

Top Publications

  1. pmc Methamphetamine enhances HIV infection of macrophages
    Hao Liang
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Pathol 172:1617-24. 2008
  2. pmc Methamphetamine toxicity and messengers of death
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, Baltimore, MD 21224, USA
    Brain Res Rev 60:379-407. 2009
  3. ncbi Single-trials analyses demonstrate that increases in clock speed contribute to the methamphetamine-induced horizontal shifts in peak-interval timing functions
    Matthew S Matell
    Department of Psychology, Villanova University, 800 Lancaster Avenue, Villanova, PA, 19085, USA
    Psychopharmacology (Berl) 188:201-12. 2006
  4. pmc Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5
    Carmela M Reichel
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 36:782-92. 2011
  5. pmc Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
    Buyean Lee
    Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024, USA
    J Neurosci 29:14734-40. 2009
  6. ncbi Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, NIH, NIDA, Intramural Research Program, Department of Health and Human Services, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
    FASEB J 17:1775-88. 2003
  7. ncbi A role for mGluR5 receptors in intravenous methamphetamine self-administration
    Megan P H Osborne
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Ann N Y Acad Sci 1139:206-11. 2008
  8. pmc FosB null mutant mice show enhanced methamphetamine neurotoxicity: potential involvement of FosB in intracellular feedback signaling and astroglial function
    Kumi O Kuroda
    Unit for Affiliative Social Behavior, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 35:641-55. 2010
  9. pmc Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys
    Maria Cecilia Garibaldi Marcondes
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    Am J Pathol 177:355-61. 2010
  10. ncbi Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
    Mol Pharmacol 65:1293-301. 2004

Detail Information

Publications367 found, 100 shown here

  1. pmc Methamphetamine enhances HIV infection of macrophages
    Hao Liang
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Pathol 172:1617-24. 2008
    Epidemiological studies have demonstrated that the use of methamphetamine (meth), a sympathomimetic stimulant, is particularly common among patients infected with HIV...
  2. pmc Methamphetamine toxicity and messengers of death
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, Baltimore, MD 21224, USA
    Brain Res Rev 60:379-407. 2009
    b>Methamphetamine (METH) is an illicit psychostimulant that is widely abused in the world. Several lines of evidence suggest that chronic METH abuse leads to neurodegenerative changes in the human brain...
  3. ncbi Single-trials analyses demonstrate that increases in clock speed contribute to the methamphetamine-induced horizontal shifts in peak-interval timing functions
    Matthew S Matell
    Department of Psychology, Villanova University, 800 Lancaster Avenue, Villanova, PA, 19085, USA
    Psychopharmacology (Berl) 188:201-12. 2006
    ..However, the generality of these results has been inconsistent in the literature...
  4. pmc Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5
    Carmela M Reichel
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 36:782-92. 2011
    Chronic methamphetamine (meth) abuse can lead to persisting cognitive deficits...
  5. pmc Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
    Buyean Lee
    Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024, USA
    J Neurosci 29:14734-40. 2009
    While methamphetamine addiction has been associated with both impulsivity and striatal dopamine D(2)/D(3) receptor deficits, human studies have not directly linked the latter two entities...
  6. ncbi Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, NIH, NIDA, Intramural Research Program, Department of Health and Human Services, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
    FASEB J 17:1775-88. 2003
    b>Methamphetamine (METH) is a drug of abuse that has long been known to damage monoaminergic systems in the mammalian brain...
  7. ncbi A role for mGluR5 receptors in intravenous methamphetamine self-administration
    Megan P H Osborne
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Ann N Y Acad Sci 1139:206-11. 2008
    ..However, the ability of mGluR5 antagonists to alter the reinforcing effects of methamphetamine has not yet been explored...
  8. pmc FosB null mutant mice show enhanced methamphetamine neurotoxicity: potential involvement of FosB in intracellular feedback signaling and astroglial function
    Kumi O Kuroda
    Unit for Affiliative Social Behavior, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 35:641-55. 2010
    ..1) two members of fos family transcription factors, c-Fos and FosB, are induced in frontal brain regions by methamphetamine; (2) null mutation of c-Fos exacerbates methamphetamine-induced neurotoxicity; and (3) null mutation of FosB ..
  9. pmc Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys
    Maria Cecilia Garibaldi Marcondes
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    Am J Pathol 177:355-61. 2010
    b>Methamphetamine (Meth) abuse increases risky behaviors that contribute to the spread of HIV infection...
  10. ncbi Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
    Mol Pharmacol 65:1293-301. 2004
    ..Little is known about molecular mechanisms for long-lasting neuroadaptation related to the rewarding effects of methamphetamine (MAP)...
  11. pmc Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling
    David M Thomas
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
    J Neurochem 106:696-705. 2008
    b>Methamphetamine (METH) damages dopamine (DA) nerve endings by a process that has been linked to microglial activation but the signaling pathways that mediate this response have not yet been delineated. Cardona et al. [Nat. Neurosci...
  12. ncbi Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurochem 100:1579-88. 2007
    ..Here, we investigated whether MMP-2 and MMP-9 are involved in the rewarding effects of and sensitization to methamphetamine (METH) in animals, in which the remodelling of neural circuits may play a crucial role...
  13. ncbi Effects of methamphetamine dependence and HIV infection on cerebral morphology
    Terry L Jernigan
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 9151B, USA
    Am J Psychiatry 162:1461-72. 2005
    The authors examined the separate and combined effects of methamphetamine dependence and HIV infection on brain morphology.
  14. pmc Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, 301 Multi Research Building, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    Brain Res 1203:133-48. 2008
    ..Neuropathogenesis of HIV-1 is exacerbated by drugs of abuse such as methamphetamine (Meth) which are capable of dysregulating BBB function...
  15. pmc Methamphetamine inhibits antigen processing, presentation, and phagocytosis
    Zsolt Talloczy
    Department of Neurology, Columbia University, New York, New York, United States of America
    PLoS Pathog 4:e28. 2008
    b>Methamphetamine (Meth) is abused by over 35 million people worldwide...
  16. ncbi Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Neurochem 96:706-18. 2006
    ..we showed that administration of a single low dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or methamphetamine (METH), a paradigm that causes selective degeneration of striatal dopaminergic nerve terminals without ..
  17. pmc Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse
    Eric C Peterson
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    J Pharmacol Exp Ther 322:30-9. 2007
    ..This is especially important when attempting to discover therapeutic mAb against the drugs of abuse (+)-methamphetamine [(+)-METH], (+)-amphetamine [(+)-AMP], and the related compound (+)-3,4-methylenedioxymethamphetamine [(+)-..
  18. pmc Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes
    Ankit Shah
    Division of Pharmacology, UMKC School of Pharmacy, Kansas City, MO 64108, USA
    J Neuroinflammation 9:52. 2012
    b>Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated...
  19. ncbi Major physical and psychological harms of methamphetamine use
    Shane Darke
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia
    Drug Alcohol Rev 27:253-62. 2008
    The major physical and psychological health effects of methamphetamine use, and the factors associated with such harms.
  20. ncbi Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses
    Ju Wang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Mol Neurobiol 44:269-86. 2011
    ..protein expression patterns in animal or human brain tissues after the administration of alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine/heroin/butorphanol, or nicotine...
  21. pmc Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study
    Isabelle Boileau
    Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 32:1353-9. 2012
    ..We tested the hypothesis that D3 receptor binding is above normal in methamphetamine (MA) polydrug users, using PET and the D3-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin ([11C]-(..
  22. ncbi Effects of murine-derived anti-methamphetamine monoclonal antibodies on (+)-methamphetamine self-administration in the rat
    D E McMillan
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72204, USA
    J Pharmacol Exp Ther 309:1248-55. 2004
    Two murine-derived anti-methamphetamine monoclonal antibodies were studied as potential pharmacokinetic antagonists of (+)-methamphetamine self-administration by rats...
  23. pmc Methamphetamine toxicity and its implications during HIV-1 infection
    Peter S Silverstein
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Neurovirol 17:401-15. 2011
    Over the past two decades methamphetamine (MA) abuse has seen a dramatic increase. The abuse of MA is particularly high in groups that are at higher risk for HIV-1 infection, especially men who have sex with men (MSM)...
  24. ncbi Methamphetamine use and schizophrenia: a population-based cohort study in California
    Russell C Callaghan
    Centre for Addiction and Mental Health, Toronto
    Am J Psychiatry 169:389-96. 2012
    Clinical investigators in Japan have long suggested that exposure to methamphetamine might cause a persistent schizophrenia-like psychosis. This possibility is discounted in the Western literature...
  25. ncbi Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Ann N Y Acad Sci 1141:96-104. 2008
    ..In vitro treatment of cortical neuron/glia cocultures with either methamphetamine or morphine caused activation of astrocytes via protein kinase C (PKC)...
  26. pmc Pharmacological approaches to methamphetamine dependence: a focused review
    Laurent Karila
    Addiction Research and Treatment Center, Paul Brousse Hospital, Paris XI University, AP HP, CEA INSERM U1000, Villejuif, France
    Br J Clin Pharmacol 69:578-92. 2010
    b>Methamphetamine dependence is a serious worldwide public health problem with major medical, psychiatric, socioeconomic and legal consequences...
  27. ncbi Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity
    Matthew J LaVoie
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Neurol 187:47-57. 2004
    Previous studies have demonstrated methamphetamine (METH)-induced toxicity to dopaminergic and serotonergic axons in rat striatum...
  28. pmc Methamphetamine-induced dopamine-independent alterations in striatal gene expression in the 6-hydroxydopamine hemiparkinsonian rats
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 5:e15643. 2010
    ..We also examined whether a single injection of methamphetamine (METH) (2...
  29. pmc Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells
    Servio H Ramirez
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cereb Blood Flow Metab 29:1933-45. 2009
    b>Methamphetamine (METH), a potent stimulant with strong euphoric properties, has a high abuse liability and long-lasting neurotoxic effects...
  30. ncbi Syphilis and methamphetamine use among female sex workers in Shandong Province, China
    Meizhen Liao
    Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, Shandong Province 250012, People s Republic of China
    Sex Transm Dis 38:57-62. 2011
    A study of female sex workers in China, found alarmingly high prevalence of methamphetamine use. Methamphetamine users were more likely to be single, younger, inconsistent condom users, and have syphilis.
  31. ncbi Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Synapse 62:91-100. 2008
    Studies in abstinent methamphetamine (METH) users have demonstrated reductions in brain dopamine transporter (DAT) binding potential (BP), as well as cognitive and motor deficits, but it is not yet clear whether cognitive deficits and ..
  32. ncbi Methamphetamine-induced structural plasticity in the dorsal striatum
    Jakub P Jedynak
    Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA
    Eur J Neurosci 25:847-53. 2007
    ..We hypothesized therefore that repeated exposure to methamphetamine would differentially alter the density of dendritic spines on medium spiny neurons (MSNs) in the dorsolateral ..
  33. ncbi Methamphetamine-induced inhibition of mitochondrial complex II: roles of glutamate and peroxynitrite
    Jeffrey M Brown
    Department of Pharmacology and Experimental Therapeutics, Laboratory of Neurochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 95:429-36. 2005
    High-dose methamphetamine (METH) is associated with long-term deficits in dopaminergic systems. Although the mechanism(s) which contributes to these deficits is not known, glutamate and peroxynitrite are likely to play a role...
  34. ncbi Habit formation and the loss of control of an internal clock: inverse relationship between the level of baseline training and the clock-speed enhancing effects of methamphetamine
    Ruey Kuang Cheng
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Psychopharmacology (Berl) 193:351-62. 2007
    ..How this relationship changes as a function of repeated experience with the reinforcement contingencies and the gradual adaptation of the underlying neural circuits remains unclear...
  35. pmc Acute methamphetamine intoxication: brain hyperthermia, blood-brain barrier, brain edema, and morphological cell abnormalities
    Eugene A Kiyatkin
    Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Int Rev Neurobiol 88:65-100. 2009
    b>Methamphetamine (METH) is a powerful and often abused stimulant with potent addictive and neurotoxic properties...
  36. ncbi Methamphetamine induces apoptosis in an immortalized rat striatal cell line by activating the mitochondrial cell death pathway
    Xiaolin Deng
    Molecular Neuropsychiatry Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 42:837-45. 2002
    b>Methamphetamine is a neurotoxic drug of abuse known to cause cell death both in vitro and in vivo. Nevertheless, the molecular and cellular mechanisms involved in this process remain to be clarified...
  37. ncbi Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neuropharmacology 58:452-6. 2010
    ..making 5-HT1A receptor gene (HTR1A) an adequate candidate gene for the pathophysiology of schizophrenia and methamphetamine (METH)-induced psychosis...
  38. pmc Methamphetamine causes microglial activation in the brains of human abusers
    Yoshimoto Sekine
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 28:5756-61. 2008
    b>Methamphetamine is a popular addictive drug whose use is associated with multiple neuropsychiatric adverse events and toxic to the dopaminergic and serotonergic systems of the brain...
  39. pmc Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis
    Thomas S Guillot
    Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia, USA
    J Neurochem 106:2205-17. 2008
    ..and that this production of oxidative stress is thought to be a critical factor in DA terminal loss after methamphetamine (METH) exposure...
  40. ncbi Meth/amphetamine use and associated HIV: Implications for global policy and public health
    Louisa Degenhardt
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    Int J Drug Policy 21:347-58. 2010
    ..Amphetamine or methamphetamine (meth/amphetamine, M/A) use was documented in 110 countries, and injection in 60 of those...
  41. pmc Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration : early loss of TH in striosomes after methamphetamine
    Noelia Granado
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Avda Dr Arce 37, 28002, Madrid, Spain
    Neurotox Res 18:48-58. 2010
    b>Methamphetamine (METH), a commonly abused psychostimulant, causes dopamine neurotoxicity in humans, rodents, and nonhuman primates...
  42. ncbi Current research on methamphetamine-induced neurotoxicity: animal models of monoamine disruption
    Taizo Kita
    Department of Pharmacology, Nara Medical University, Nara, Japan
    J Pharmacol Sci 92:178-95. 2003
    b>Methamphetamine (METH)-induced neurotoxicity is characterized by a long-lasting depletion of striatal dopamine (DA) and serotonin as well as damage to striatal dopaminergic and serotonergic nerve terminals...
  43. ncbi Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers.
  44. pmc Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis
    Subramaniam Jayanthi
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 102:868-73. 2005
    b>Methamphetamine [METH ("speed")] is an abused psychostimulant that can cause psychotic, cognitive, and psychomotor impairment in humans...
  45. ncbi Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:9414-8. 2001
    b>Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals...
  46. ncbi Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: role of tight junction proteins and matrix metalloproteinase-9
    Tânia Martins
    Laboratory of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, 3004 548 Coimbra, Portugal
    Brain Res 1411:28-40. 2011
    b>Methamphetamine (METH) is a powerful stimulant drug of abuse that has steadily gained popularity worldwide...
  47. ncbi The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy
    Chutikorn Nopparat
    Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakornpathom, Thailand
    J Pineal Res 49:382-9. 2010
    b>Methamphetamine (METH) is a common drug of abuse that induces toxicity in the central nervous system and is connected to neurological disorders such as Parkinson's disease...
  48. ncbi Brain edema and breakdown of the blood-brain barrier during methamphetamine intoxication: critical role of brain hyperthermia
    Eugene A Kiyatkin
    Behavioural Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 26:1242-53. 2007
    ..the role of brain temperature in permeability of the blood-brain barrier (BBB), rats were injected with methamphetamine (METH 9 mg/kg) at normal (23 degrees C) and warm (29 degrees C) environmental conditions and internal ..
  49. pmc The need for speed: an update on methamphetamine addiction
    Alasdair M Barr
    Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Psychiatry Neurosci 31:301-13. 2006
    The psychostimulant methamphetamine (MA) is a highly addictive drug that has surged in popularity over the last decade in North America...
  50. ncbi Methamphetamine enhances histoplasmosis by immunosuppression of the host
    Luis R Martinez
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:131-41. 2009
    The effect of methamphetamine on the host response to an opportunistic pathogen has not been extensively described. Methamphetamine is a major public health and safety problem in the United States...
  51. ncbi Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain
    Joana Gonçalves
    Institute of Pharmacology and Therapeutics, and Biomedical Institute for Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Ann N Y Acad Sci 1139:103-11. 2008
    The mechanisms by which methamphetamine (METH) causes neurotoxicity are not well understood...
  52. ncbi Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines
    Jiraporn Tocharus
    Department of Biochemistry, Naresuan University, Phitsanulok, Thailand
    J Pineal Res 48:347-52. 2010
    b>Methamphetamine (METH), the most commonly abused drug, has long been known to induce neurotoxicity...
  53. ncbi Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascades
    Subramaniam Jayanthi
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institute of Health, DHHS, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    FASEB J 18:238-51. 2004
    b>Methamphetamine (METH) is an illicit drug that causes neurodegenerative effects in humans. In rodents, METH induces apoptosis of striatal glutamic acid decarboxylase (GAD) -containing neurons...
  54. ncbi Molecular bases of methamphetamine-induced neurodegeneration
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, NIDA Intramural Research Program, NIH DHHS, Baltimore, Maryland 21224, USA
    Int Rev Neurobiol 88:101-19. 2009
    b>Methamphetamine (METH) is a highly addictive psychostimulant drug, whose abuse has reached epidemic proportions worldwide...
  55. ncbi Neurocognitive effects of methamphetamine: a critical review and meta-analysis
    J Cobb Scott
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA 92120, USA
    Neuropsychol Rev 17:275-97. 2007
    This review provides a critical analysis of the central nervous system effects of acute and chronic methamphetamine (MA) use, which is linked to numerous adverse psychosocial, neuropsychiatric, and medical problems...
  56. ncbi Methamphetamine causes widespread apoptosis in the mouse brain: evidence from using an improved TUNEL histochemical method
    X Deng
    NIH/NIDA-IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Mol Brain Res 93:64-9. 2001
    ..Thereafter, methamphetamine (METH)-induced neuronal death was investigated in mice brains...
  57. pmc Amphetamine toxicities: classical and emerging mechanisms
    Bryan K Yamamoto
    Department of Neurosciences, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    Ann N Y Acad Sci 1187:101-21. 2010
    The drugs of abuse, methamphetamine and MDMA, produce long-term decreases in markers of biogenic amine neurotransmission...
  58. pmc Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells
    Emily S Wires
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Neurovirol 18:400-10. 2012
    ..Recent evidence suggests that HIV-infected individuals who abuse drugs such as methamphetamine (METH) have higher viral loads and experience more severe neurological complications than HIV-infected ..
  59. ncbi Nonmedical use of prescription stimulants in the United States
    Larry A Kroutil
    RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA
    Drug Alcohol Depend 84:135-43. 2006
    ..This study estimated prevalences and correlates of stimulant diversion in the United States and examined relationships between diversion and measures of abuse or dependence...
  60. ncbi Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats
    Kelly A Byrnes-Blake
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Eur J Pharmacol 521:86-94. 2005
    The roles of monoclonal antibody affinity and treatment time of (+)-methamphetamine-induced pharmacological effects in rats were studied using two anti-(+)-methamphetamine monoclonal antibodies...
  61. pmc Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s)
    Julie S Pendergast
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235 1634, USA
    Proc Natl Acad Sci U S A 109:14218-23. 2012
    ..In mammals, two circadian clocks, the food-entrainable oscillator (FEO) and methamphetamine-sensitive circadian oscillator (MASCO), are "black box" mysteries because their anatomical loci are unknown ..
  62. ncbi Text messaging reduces HIV risk behaviors among methamphetamine-using men who have sex with men
    Cathy J Reback
    Friends Research Institute, Inc, 1419 N La Brea Avenue, Los Angeles, CA 90028, USA
    AIDS Behav 16:1993-2002. 2012
    ..was an open label pilot study testing the feasibility and utility of a text-messaging intervention to reduce methamphetamine use and high-risk sexual behaviors among out-of-treatment MSM...
  63. pmc Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens
    Tracey A Martin
    Molecular Neuropsychiatry Research Branch, NIH NIDA Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 7:e34236. 2012
    b>Methamphetamine (METH) addiction is associated with several neuropsychiatric symptoms. Little is known about the effects of METH on gene expression and epigenetic modifications in the rat nucleus accumbens (NAC)...
  64. pmc HIV-1 gp120 and drugs of abuse: interactions in the central nervous system
    Peter S Silverstein
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Curr HIV Res 10:369-83. 2012
    ..In many patients, the use of drugs of abuse (DOA) exacerbates the neurotoxic effects of gp120. Cocaine, methamphetamine and morphine are three DOAs that are commonly used by those infected with HIV-1...
  65. ncbi Treatment with low-dose methamphetamine improves behavioral and cognitive function after severe traumatic brain injury
    Thomas F Rau
    Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USA
    J Trauma Acute Care Surg 73:S165-72. 2012
    b>Methamphetamine increases the release and blocks the reuptake of dopamine. The moderate activation of dopamine receptors may elicit neuroprotective effects...
  66. ncbi Methamphetamine-induced neurotoxicity: the road to Parkinson's disease
    Bessy Thrash
    Department of Pharmacological Sciences, Harrison School of Pharmacy, Auburn University, 4306 Walker building, Auburn, AL 36849, USA
    Pharmacol Rep 61:966-77. 2009
    Studies have implicated methamphetamine exposure as a contributor to the development of Parkinson's disease...
  67. ncbi Differential responses of circadian Per2 expression rhythms in discrete brain areas to daily injection of methamphetamine and restricted feeding in rats
    Akiyo Natsubori
    Department of Chronomedicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Neurosci 37:251-8. 2013
    Behavioral rhythms induced by methamphetamine (MAP) and daily restricted feeding (RF) in rats are independent of the circadian pacemaker in the suprachiasmatic nucleus (SCN), and have been regarded to share a common oscillatory mechanism...
  68. pmc Methamphetamine use and neuropsychiatric factors are associated with antiretroviral non-adherence
    David J Moore
    Department of Psychiatry, University of California, San Diego, San Diego, CA, USA
    AIDS Care 24:1504-13. 2012
    The present study assesses the impact of methamphetamine (METH) on antiretroviral therapy (ART) adherence among HIV+ persons, as well as examines the contribution of neurocognitive impairment and other neuropsychiatric factors [i.e...
  69. pmc Methamphetamine increases LPS-mediated expression of IL-8, TNF-α and IL-1β in human macrophages through common signaling pathways
    Xun Liu
    Division of Pharmacology and Toxicology, School of Pharmacy, School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America
    PLoS ONE 7:e33822. 2012
    The use of methamphetamine (MA) has increased in recent years, and is a major health concern throughout the world...
  70. ncbi Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine
    Wayne A Cass
    Department of Anatomy and Neurobiology, MN 225 Chandler Medical Center, University of KY, Lexington, KY 40536 0298, USA
    Ann N Y Acad Sci 1074:261-71. 2006
    Repeated methamphetamine (METH) administration to animals can result in long-lasting decreases in brain dopamine (DA) and serotonin (5-HT) content...
  71. pmc Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells
    M Lin
    Parkinson s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA
    Neuroscience 210:308-32. 2012
    A compromised protein degradation machinery has been implicated in methamphetamine (MA)-induced neurodegeneration...
  72. pmc Genome-wide association for methamphetamine sensitivity in an advanced intercross mouse line
    C C Parker
    Department of Human Genetics, The University of Chicago, IL 60637, USA
    Genes Brain Behav 11:52-61. 2012
    Sensitivity to the locomotor stimulant effects of methamphetamine (MA) is a heritable trait that utilizes neurocircuitry also associated with the rewarding effects of drugs...
  73. pmc The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue
    Michael H Baumann
    Translational Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 37:1192-203. 2012
    ..with those produced by the structurally related compounds, 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine. In vitro release assays using rat brain synaptosomes revealed that mephedrone and methylone are nonselective ..
  74. pmc Crystal methamphetamine use and sexual risk behaviors among HIV-positive and HIV-negative men who have sex with men in South Florida
    David W Forrest
    Department of Epidemiology and Public Health, University of Miami School of Medicine, 1120 N W 14th Street, Suite 915, Miami, FL 33136, USA
    J Urban Health 87:480-5. 2010
    ..National HIV Behavioral Surveillance Among Men Who Have Sex with Men, we estimate the prevalence of crystal methamphetamine use and its association with high-risk sexual behaviors among a large and diverse sample of men who have sex ..
  75. ncbi Feasibility and promise of a couple-based HIV/STI preventive intervention for methamphetamine-using, black men who have sex with men
    Elwin Wu
    Social Intervention Group, Columbia University School of Social Work, New York, NY, USA
    AIDS Behav 15:1745-54. 2011
    ..have sex with men (MSM) from populations with elevated rates of HIV/STI transmission, such as black MSM and methamphetamine-involved MSM...
  76. ncbi Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats
    Kelly A Byrnes-Blake
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 611, Little Rock, AR 72205, USA
    Eur J Pharmacol 461:119-28. 2003
    ..mechanisms involved in high-affinity (K(d) approximately 11 nM) monoclonal antibody-based antagonism of (+)-methamphetamine-induced locomotor effects. Male rats received (+)-methamphetamine (0.3, 1, or 3 mg/kg i.v...
  77. ncbi Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum
    Noelia Granado
    Instituto Cajal, CSIC, Madrid, Spain
    Glia 59:1850-63. 2011
    ..with damage to nigrostriatal dopaminergic neurons and reactive gliosis in the basal ganglia is a hallmark of methamphetamine (METH) toxicity...
  78. pmc Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes
    Ankit Shah
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, USA
    PLoS ONE 7:e52060. 2012
    ..Recently we have shown that methamphetamine (MA) also increases expression of proinflammatory cytokines in astrocytes...
  79. ncbi Common transcriptional effects in the mouse striatum following chronic treatment with heroin and methamphetamine
    M Piechota
    Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Smetna 12, Krakow, Poland
    Genes Brain Behav 11:404-14. 2012
    ..of transcriptional alterations in the mouse striatum during chronic treatment with heroin (HER) and methamphetamine (METH) and after period of spontaneous withdrawal...
  80. ncbi Sensitized increase of period gene expression in the mouse caudate/putamen caused by repeated injection of methamphetamine
    T Nikaido
    Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan
    Mol Pharmacol 59:894-900. 2001
    b>Methamphetamine (MAP) causes the sensitization phenomena not only in MAP-induced locomotor activity, dopamine release, and Fos expression, but also in MAP-induced circadian rhythm...
  81. ncbi Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings
    William J Panenka
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Drug Alcohol Depend 129:167-79. 2013
    b>Methamphetamine (MA) is a highly addictive psychostimulant drug that principally affects the monoamine neurotransmitter systems of the brain and results in feelings of alertness, increased energy and euphoria...
  82. ncbi Psychosocial and behavioral correlates of depressed mood among female methamphetamine users
    Shirley J Semple
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, USA
    J Psychoactive Drugs . 2007
    Female methamphetamine (meth) users report more depressive symptoms than do males. This study examined psychosocial and behavioral correlates of depressed mood in 146 heterosexual, meth-using women in San Diego, CA...
  83. pmc Withdrawal symptoms in abstinent methamphetamine-dependent subjects
    Todd Zorick
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Addiction 105:1809-18. 2010
    ..Inasmuch as this association applies to methamphetamine (MA) abuse, an understanding of the course of MA withdrawal symptoms may help to direct treatment for MA ..
  84. ncbi The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease
    Scott L Letendre
    Department of Medicine, University of California San Diego, CA 92103, USA
    AIDS 19:S72-8. 2005
    ..To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance...
  85. pmc Increased drug use and STI risk with injection drug use among HIV-seronegative heterosexual methamphetamine users
    W Susan Cheng
    Native American Alliance for Emergency Preparedness NAAEP, California Department of Health Care Services, Davis, CA, USA
    J Psychoactive Drugs 42:11-8. 2010
    b>Methamphetamine (MA) use has been found to be associated with increased risk of HIV and sexually transmitted infections (STI) among men having sex with men, but it is unknown whether those who inject MA are at greater risk for these ..
  86. ncbi Chronic stress enhances methamphetamine-induced extracellular glutamate and excitotoxicity in the rat striatum
    Despina A Tata
    Laboratory of Neurochemistry, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Synapse 62:325-36. 2008
    Striking parallels exist between the neurochemical and toxic effects of stress and methamphetamine. Despite these similarities, no studies have examined how stress may promote the toxic effects of methamphetamine (METH)...
  87. ncbi Psychiatric comorbidity and gender differences of persons incarcerated for methamphetamine abuse in Taiwan
    Shih Ku Lin
    Department of Addiction Science, Taipei City Psychiatric Center, Taipei, Taiwan
    Psychiatry Clin Neurosci 58:206-12. 2004
    b>Methamphetamine (MAP) abuse has been common in Taiwan for the past decade. The purpose of the present study was to investigate MAP abuse in Taiwan, with specific attention to psychiatric comorbidity and gender differences...
  88. pmc A comparison of amphetamine- and methamphetamine-induced locomotor activity in rats: evidence for qualitative differences in behavior
    Darien A Hall
    Department of Psychology and Neuroscience Program, University of Illinois at Urbana Champaign, 731 Psychology Bldg MC 716, 603 E Daniel St, Champaign, IL 61820, USA
    Psychopharmacology (Berl) 195:469-78. 2008
    b>Methamphetamine (METH) is typically characterized as a more potent psychostimulant than amphetamine (AMPH), but few studies have directly compared the effects of these drugs at low, behaviorally activating doses that tend not to produce ..
  89. ncbi The rise of methamphetamine in Southeast and East Asia
    Rebecca McKetin
    National Drug and Alcohol Research Centre, University of New South Wales, Australia
    Drug Alcohol Rev 27:220-8. 2008
    Southeast and East Asia has become a global hub for methamphetamine production and trafficking over the past decade. This paper describes the rise of methamphetamine supply and to what extent use of the drug is occurring in the region.
  90. pmc Effects of oral methamphetamine on cocaine use: a randomized, double-blind, placebo-controlled trial
    Marc E Mooney
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55414, USA
    Drug Alcohol Depend 101:34-41. 2009
    ..g., amphetamine analogues, may be a productive strategy for medication development...
  91. ncbi Increased risk of Parkinson's disease in individuals hospitalized with conditions related to the use of methamphetamine or other amphetamine-type drugs
    Russell C Callaghan
    Centre for Addiction and Mental Health, 33 Russell St, Toronto, ON M5S 2S1, Canada
    Drug Alcohol Depend 120:35-40. 2012
    Since methamphetamine and other amphetamine-type stimulants (meth/amphetamine) can damage dopaminergic neurons, researchers have long speculated that these drugs may predispose users to develop Parkinson's disease (PD), a dopamine ..
  92. pmc Chronic methamphetamine exposure suppresses the striatal expression of members of multiple families of immediate early genes (IEGs) in the rat: normalization by an acute methamphetamine injection
    Michael T McCoy
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, NIDA NIH, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 215:353-65. 2011
    ..Repeated injections of cocaine cause blunted responses to acute cocaine challenge-induced increases in the expression of immediate early genes (IEGs)...
  93. ncbi Neonatal exposure to MK-801, an N-methyl-D-aspartate receptor antagonist, enhances methamphetamine-induced locomotion and disrupts sensorimotor gating in pre- and postpubertal rats
    Takashi Uehara
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Sugitani, Toyama, Japan
    Brain Res 1352:223-30. 2010
    ..For this purpose, we examined methamphetamine (MAP; 1.0mg/kg, i.p...
  94. ncbi Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels
    Sandra Vergo
    Department of Molecular Biology, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    Brain Res 1185:18-32. 2007
    ..potassium-induced dopamine release and attenuates cell death induced by the cytosolic dopamine enhancer, methamphetamine, suggesting an enhancement in vesicular dopamine storage...
  95. ncbi Mephedrone (4-methylmethcathinone, 'meow'): acute behavioural effects and distribution of Fos expression in adolescent rats
    Craig P Motbey
    School of Psychology, University of Sydney, NSW 2006, Australia
    Addict Biol 17:409-22. 2012
    ..Users report mephedrone as having the stimulant-like qualities of methamphetamine and cocaine, combined with the prosocial, entactogenic effects of 3,4-methylenedioxymethamphetamine (MDMA)...
  96. ncbi Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers
    Norikazu Ezaki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Ann N Y Acad Sci 1139:49-56. 2008
    Accumulating evidence suggests that genetic factors contribute to the vulnerability to methamphetamine (MAP) abuse and associated psychiatric symptoms. Chronic MAP abuse leads to psychosis, which may be of a transient or a prolonged type...
  97. pmc Modulation of the proteome of peripheral blood mononuclear cells from HIV-1-infected patients by drugs of abuse
    Jessica L Reynolds
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, Buffalo General Hospital, University at Buffalo, State University of New York at Buffalo, 311 MultiLab Research Building, Buffalo, NY, 14203, USA
    J Clin Immunol 29:646-56. 2009
    ..We used proteomic analyses to assess how drug abuse modulates immunologic responses to infections with the human immunodeficiency virus type 1 (HIV-1)...
  98. ncbi Decision making by methamphetamine-dependent subjects is associated with error-rate-independent decrease in prefrontal and parietal activation
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine and Department of Psychiatry, University of California at San Diego, La Jolla, 92093 0603, USA
    Biol Psychiatry 53:65-74. 2003
    ..In a previous investigation, methamphetamine-dependent subjects (MD) selected win-stay/lose-shift consistent responses than normal comparison subjects (NC)..
  99. pmc Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae
    Minseon Park
    Department of Neurosurgery, University of Kentucky, KY 40536, USA
    J Cell Mol Med 16:362-75. 2012
    b>Methamphetamine (METH) is a drug of abuse with neurotoxic and vascular effects that may be mediated by reactive oxygen species (ROS). However, potential sources of METH-induced generation of ROS are not fully understood...
  100. ncbi Comparison of ELISAs for opiates, methamphetamine, cocaine metabolite, benzodiazepines, phencyclidine, and cannabinoids in whole blood and urine
    S Kerrigan
    California Department of Justice, Bureau of Forensic Services, Toxicology Laboratory, 4949 Broadway, Sacramento, CA 95820, USA
    Clin Chem 47:540-7. 2001
    ..ELISAs are widely utilized in forensic drug analysis. A comparative assessment of microtiter plate assays for the detection of six common classes of drug in blood and urine is described...
  101. pmc Methamphetamine causes sustained depression in cerebral blood flow
    Oksana Polesskaya
    Department of Microbiology and Immunology, The University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Brain Res 1373:91-100. 2011
    The use prevalence of the highly addictive psychostimulant methamphetamine (MA) has been steadily increasing over the past decade...

Research Grants70

  1. Epigenetic Regulation of Serotonin:Relevance to HIV and Methamphetamine Abuse
    GREGORY MICHAEL MILLER; Fiscal Year: 2012
    ..provided by applicant): Project Summary Understanding the biological mechanisms that link HIV infection, methamphetamine dependence and consequent changes in the serotonin system that correlate to depression, stress and disruption ..
  2. Glial-neuronal interactions underlying the molecular feedback between HIV viral p
    Sulie L Chang; Fiscal Year: 2013
    ..this research is to delineate the possible mechanisms underlying the increased abuse of substances, such as methamphetamine (METH), by individuals who are human immunodeficiency virus-1 (HIV)-positive...
  3. Developing Immunotherapeutics for Methamphetamine Abuse
    THOMAS RICHARD KOSTEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Immunization against methamphetamine (MA) is potentially valuable in assisting patients in stopping their abuse...
  4. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The proposed project will carry out a detailed study of how morphine, methamphetamine, alcohol each affect sulfur metabolism and antioxidant status in cultured human neuroblastoma cells and ..
  5. A novel and powerful C. elegans behavioral model of addiction
    Eric A Engleman; Fiscal Year: 2013
    ..movement toward, and concentration- dependent self-exposure to, various psychoactive drugs including cocaine, methamphetamine, ethanol and caffeine...
  6. Free Radicals and Methamphetamine Abuse
    Maria Cecilia Garibaldi Marcondes; Fiscal Year: 2010
    b>Methamphetamine is one of the most growing drugs of abuse, causing neurological impairments, and associated with behaviors that favor exposure to HIV, a virus that penetrates the CNS leading to neuroAIDS...
  7. New Inactivators of GABA Aminotransferase for Addiction
    Richard B Silverman; Fiscal Year: 2013
    ..Increasing GABA levels blocks cocaine, nicotine, methamphetamine, alcohol, and heroin addiction in rats and cocaine addiction in humans without affecting the craving for food...
  8. In vivo mechanisms of methamphetamine-induced neuronal necrosis
    Denson G Fujikawa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our overall objective is to understand how methamphetamine (METH) kills neurons, and whether this can be ameliorated or eliminated with pharmacologic intervention...
  9. MAGNETIZATION TRANSFER MRS IN METHAMPHETAMINE USERS RESUBMISSION
    Young Hoon Sung; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Methamphetamine (METH) users have compromised frontal-striatal brain systems, which include brain areas associated with inhibitory control, decision-making, working memory, and impulse control...
  10. Impact CYP2D6 Phenotype on Response to Methamphetamine in Humans
    Alison Oliveto; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Methamphetamine (METH) dependence is prevalent in several regions of the US and has serious medical and social consequences...
  11. mGluR5 antagonists for methamphetamine addiction
    M Foster Olive; Fiscal Year: 2012
    b>Methamphetamine addiction is growing national public health problem, yet to date there are no approved pharmacological treatments for this disorder...
  12. DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM
    Reese T Jones; Fiscal Year: 2013
    ..of interest to participating projects and assays available include nicotine and its metabolites, cocaine, methamphetamine and other phenethylamines, alcohol, MDMA, ephedra alkaloids, caffeine, gamma hydroxybutyrate (GHB), ..
  13. Mechanisms and Interventions for Methamphetamine and HIV-1 Induced CNS Injury
    Yuri Persidsky; Fiscal Year: 2013
    ABSTRACT: Methamphetamine (METH), an addictive stimulant has long lasting toxic effects on the central nervous system (CNS)...
  14. Dopamine Exacerbates NeuroAIDS by Activation of Macrophage Dopaminergic System
    PETER JESSE GASKILL; Fiscal Year: 2013
    ..HIV infected individuals who abuse methamphetamine and cocaine show a significant increase in the incidence and severity of neuropathology and in the ..
  15. Drug tourism to Mexico: Impact of Mexicos new drug law on HIV-HCV-TB in US IDUs
    Richard S Garfein; Fiscal Year: 2013
    ..controversial law decriminalizing possession of personal-sized quantities of drugs including heroin, cocaine, methamphetamine and cannabis...
  16. Methamphetamine and Immune Cells in NeuroAIDS
    Maria Cecilia Garibaldi Marcondes; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Methamphetamine (Meth) abuse leads to behaviors that increase the risk of exposure to HIV1-3...
  17. Identification of Biomarkers for BBB Injury-Induced by Drugs and HIV-1 Proteins
    Sheng He Huang; Fiscal Year: 2013
    ..g., methamphetamine (METH), marijuana, opiates] and legal substances such as alcohol and nicotine (NT), a major component of ..
  18. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John P Capitanio; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Worldwide, stimulants such as methamphetamine rank second only to cannabis in number of users, and in North America, the prevalence of amphetamine abuse is double the global rate...
  19. Citicoline Treatment of Methamphetamine Dependence
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2010
    b>Methamphetamine (MA) dependence is a highly disabling and refractory condition, which results in serious impairment in social and occupational functioning...
  20. Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1
    JOAN WEINBERGER BERMAN; Fiscal Year: 2012
    ..Many drugs of abuse, including cocaine and methamphetamine, elevate extracellular dopamine levels in the CNS...
  21. Neurobehavioral and fMRI Research in HIV Infection and Cocaine Dependence
    Christina S Meade; Fiscal Year: 2013
    ..Stimulant abuse, primarily cocaine and methamphetamine, is common among HIV-infected adults and is associated with continued sexual risk taking, poor treatment ..
  22. Prevenitng HIV/STIs in Central Indian High Risk Women: A Pilot Intervention
    Thomas L Patterson; Fiscal Year: 2010
    ..S. (methamphetamine users) and Mexico (female sex workers) to the needs and circumstances of female sex workers in Nagpur, India, ..
  23. Role of Neuroinflammation in Behavioral Deficits Resulting from Chronic Alcohol
    Clare J Wilhelm; Fiscal Year: 2013
    ..The research environments of these venues are particularly strong, with alcohol-, methamphetamine-, and Alzheimer's disease research centers and the availability of numerous potential collaborators and ..
  24. PROTEASOME AND PARKIN AS DRUG TARGETS AGAINST METHAMPHETAMINE TOXICITY
    Anna Moszczynska; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Methamphetamine (METH) is a highly addictive psychostimulant drug that is neurotoxic when taken at high doses chronically or acutely...
  25. Drugs of abuse and the epigenetic and signaling pathways controlling HIV latency
    Richard M Ransohoff; Fiscal Year: 2013
    ..Consumption of drugs of abuse such as methamphetamine (METH) aggravates the symptoms of HAND, but the cellular and molecular mechanisms by which these drugs impact ..
  26. Convergent Versus Parallel Striatal Afferents
    Daniel S Zahm; Fiscal Year: 2013
    ..In contrast, locomotion elicited by injection of methamphetamine (1 mg/kg, s.c.) was blocked by an LPO infusion of the GABA A agonist muscimol...
  27. Prenatal Methamphetamine Exposure and School Aged Outcome
    Barry M Lester; Fiscal Year: 2013
    The rapidly escalating abuse of methamphetamine (METH) in the United States, places a sense of urgency on understanding the consequences of METH use during pregnancy for the developing child...
  28. Transdermal Naltrexone for Opiate Addiction and Alcoholism
    Audra L Stinchcomb; Fiscal Year: 2012
    ..trial data has also been observed in amphetamine-dependent individuals, which is especially important as methamphetamine dependence has no FDA-approved treatment options...
  29. Vulnerability to Drug Abuse and Treatment Efficacy: Animal Models
    Marilyn E Carroll; Fiscal Year: 2010
    ..COC), and that work will be extended to new areas;however, new proposed studies will also be conducted with methamphetamine (METH), a drug that has become an enormous health concern and for which prevention and treatment models are ..
  30. Novel RTL treatment to promote brain repair and cognitive recovery following meth
    JENNIFER M contact LOFTIS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Methamphetamine (MA) dependence is associated with neuropsychiatric side effects that make the addiction extremely challenging to treat...
  31. HIV-Induced Dopamnergic Changes and Methamphetamine Toxicity Mediated through Mic
    ERICK THOMAS TATRO; Fiscal Year: 2012
    ..The goal of the project is to understand how HIV-infected macrophages combine with methamphetamine (Meth) to cause alterations in dopaminergic neural cells and determine whether targeting a microRN (miR) can ..
  32. The role of dendrodendritic dopamine neurotransmission in methamphetamine abuse
    Michael J Beckstead; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Methamphetamine (METH) addiction currently presents an enormous public health issue, and yet no therapeutic agent is currently approved for its treatment...
  33. Modeling Neural Injury Effects of Methamphetamine Metabolism by CYP2D6 in HIV
    Mariana Cherner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite being the primary enzyme involved in methamphetamine (meth) metabolism, cytochrome P450-2D6 (CYP2D6) has not been studied (outside of our own work) with regard to its role in meth-related ..
  34. Investigation of Neoclerodanes as Novel Opioid Ligands
    THOMAS EDWARD PRISINZANO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Addiction to cocaine and methamphetamine, highly addictive psychostimulants, is associated with substantial neuropsychiatric morbidity, as well as enhancing transmission of HIV-1, hepatitis B and C, ..
  35. Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/Disorder
    Drake Morgan; Fiscal Year: 2013
    ..as functionally-selective serotonin 5HT2 receptor-based drug development candidates to treat amphetamine and methamphetamine addiction and drug-induced psychotic disorders...
  36. Drug Abuse-related Neurobiology and Genetic Variance Modeled in Rhesus Monkeys
    GREGORY MICHAEL MILLER; Fiscal Year: 2013
    ..for the development of novel therapeutics for neuropsychiatric and addiction disorders and particularly, for methamphetamine addiction...
  37. CYP2D6 Genotype and Cognitive Deficits in Methamphetamine Users with/without HIV
    Mariana Cherner; Fiscal Year: 2013
    ..provided by applicant): Although cytochrome P450-2D6 (CYP2D6) is the primary enzyme responsible for methamphetamine (meth) metabolism, no work has been conducted outside of our group on its role in meth-related brain ..
  38. mechanisms of HIV and drug abuse pathogenesis in CNS
    Lena Al-Harthi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Methamphetamine (Meth) is a psychostimulant that has exceeded cocaine use in the US. Drug abuse in general and Meth use in particular is a risk factor for HIV acquisition and disease progression...
  39. Methamphetamine and neurodevelopment in adolescent and adult mice
    Bertha K Madras; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Among psychostimulants, methamphetamine (METH) has one of the highest risks for progression to addiction...
  40. Chimeric anti-Methamphetamine Monoclonal Antibody for Treating Stimulant Toxicity
    R BARRY contact HOLTZ; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Overdose and abuse of methamphetamine ((+)-METH), (+)-amphetamine ((+)-AMP), or (1)- methylenedioxymethamphetamine ((1)-MDMA) exact significant medical and social costs in the USA and abroad...
  41. Neonatal Methamphetamine Effects on Adult Cholinergic and Cognitive Function
    Jessica A Siegel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The number of pregnant women using methamphetamine (MA) is increasing. Exposure to MA in utero leads to neurological and cognitive deficits in infants that persist into adulthood...
  42. METHAMPHETAMINE TOXICITY AND CORTICOSTRIATAL GLUTAMATE
    Bryan K Yamamoto; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The adverse effects of methamphetamine (METH) are of international and national concern (SAMSHA, 2010;UNODC, 2010). It is now clear the METH has toxic effects on the human brain...
  43. Impact of Violence and Power on a HIV Behavioral Intervention for Female MA Users
    JAMILA KINSHASA STOCKMAN; Fiscal Year: 2013
    ..IPV and sexual relationship power differentials on the sexual risk behaviors of HIV-negative heterosexual methamphetamine (MA)-using women enrolled in the intervention arm of an HIV behavioral intervention;2) examine whether ..
  44. PSYCHOSTIMULANT RECOGNITION BY SEROTONIN TRANSPORTERS
    Eric L Barker; Fiscal Year: 2010
    ..Abused stimulants such as cocaine and amphetamine (including methamphetamine ("Meth") and MDMA or 'ecstasy') are of great societal concern...
  45. Impact of Drug Policy Reform on the HIV Risk Environment among IDUs in Tijuana
    Steffanie A Strathdee; Fiscal Year: 2013
    ..Mexico approved a law that partially deregulates possession of small, specified amounts of cocaine, heroin, methamphetamine and marijuana for personal use...
  46. An ACE Inhibitor as a Treatment for Methamphetamine Dependence
    THOMAS FREDERICK NEWTON; Fiscal Year: 2012
    ..the effects of medications affecting angiotensin II on behaviors related to other drugs of abuse, such as methamphetamine (MA)...
  47. Dopamine Transporter Palmitoylation
    JAMES DARREN FOSTER; Fiscal Year: 2011
    ..disorders such as schizophrenia, attention deficit disorder, Parkinson's disease, and cocaine and methamphetamine addiction...
  48. Exercise as a novel strategy to target methamphetamine-induced cerebrovascular to
    Michal Toborek; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Current strategies aimed at combating methamphetamine (METH) abuse do not appear to be effective and it is likely that METH abuse will continue to increase in the future...
  49. Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)
    STEPHEN JOHN CUTLER; Fiscal Year: 2013
    ..treatment, glaucoma, and the development of sigma receptor agonists in the treatment of cocaine and methamphetamine abuse...
  50. TAAR1 polymorphisms in rhesus monkeys
    Gregory M Miller; Fiscal Year: 2010
    ..amines dopamine, norepinephrine and serotonin), as well as amphetamine-like psychostimulants, including methamphetamine. In rhesus monkey brain, we have shown that TAAR1 mRNA is expressed in monoaminergic regions, and that TAAR1 ..
  51. Human methamphetamine vaccine: Translational Avante Garde Award
    THOMAS RICHARD KOSTEN; Fiscal Year: 2013
    Item Number 7. Project Summary/Abstract: Research Plan PROJECT SUMMARY/ABSTRACT Four factors make this methamphetamine (MA) vaccine ready for clinical translation: 1. Our candidate vaccine has optimal adjuvant and antibody responses;2...
  52. Amphetamine Acts as a Molecular Stent in the Dopamine Transporter
    Louis J De Felice; Fiscal Year: 2010
    ..this term to frame another approach to the molecular explanation of how amphetamine and its close relative, methamphetamine, might work...
  53. Interaction of HIV-Tat and methamphetamine: Role of ion channels and epigenetics
    Marilou A Andres; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Methamphetamine (METH) is an illicit drug commonly used (and abused) by HIV-infected patients. METH exacerbates HIV-related neurological impairments and brain injury...
  54. Cerebrovascular mechanisms in methamphetamine-mediated exacerbation of neuroAIDS
    Stephen Dewhurst; Fiscal Year: 2012
    b>Methamphetamine (MA) use is associated with accelerated progression of HIV-associated neurocognitive disorders (HAND), through poorly understood mechanisms...
  55. RGR-based motion tracking for real-time adaptive MR imaging and spectroscopy
    THOMAS M ERNST; Fiscal Year: 2012
    ..in three target populations that are prone to motion: 1) children (3-7 years old) who were exposed to methamphetamine in utero, 2) hospitalized in- patients who require repeat MRI scans due to excessive motion, and 3) patients ..
  56. A Mechanistic Study of Methamphetamine Neurotoxicity: Involvement of HO-1 & MnSO
    MELINDA LEA ASBURY; Fiscal Year: 2010
    Project Summary: The goal of this research is to help bridge the gap between methamphetamine (MA) neurotoxicity and effective therapeutic intervention...
  57. COMT Genotype and Executive Function in HIV Infection and Methamphetamine Use
    Ian Paul Everall; Fiscal Year: 2010
    ..and the protection against the development of HIV related impaired executive function, which is lost when methamphetamine (METH) is used by the affected individuals...
  58. Neuroinflammation and Glial ROS in Methamphetamine Neurotoxicity
    Lisa A Opanashuk; Fiscal Year: 2010
    Neurological symptoms with methamphetamine (METH) toxicity of the nigrostriatal system, both in rodent models and in drug abusers, are associated with neuroinflammation, a fundamental reaction to brain injury characterized by activated ..
  59. Community-based Methamphetamine Use & HIV Risk in China
    Brian C Kelly; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The use of methamphetamine has increased dramatically in recent years in the United States, Europe, Canada, Australia, and Asia...
  60. Development of a flagellin-cocaine conjugate vaccine
    Steven B Mizel; Fiscal Year: 2010
    ..in reducing addictions to smoking and opiate abuse, there are currently no such treatments for cocaine or methamphetamine addiction...
  61. Reducing HIV risk among episodic substance-using MSM
    Phillip O Coffin; Fiscal Year: 2011
    ..We will focus on use of methamphetamine, powder or crack cocaine, poppers, and binge drinking (>5 drinks) during sex because these substances are ..
  62. Mechanism-based Changes in Anti-METH Monoclonal Antibody Therapy During Pregnancy
    WILLIAM THOMAS ATCHLEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): (+)-Methamphetamine (METH) is one of the most addictive and heavily abused drugs among pregnant women, yet there are no approved medications for protecting the vulnerable fetus or mother from its ..
  63. A New Antioxidant Prevents Toxicity of HIV Proteins with Methamphetamine
    Nuran Ercal; Fiscal Year: 2007
    ..Furthermore, many AIDs/HIV-positive patients use addictive drugs such as methamphetamine (METH). Among these addictive drugs, METH, in particular, induces free radicals in various cells...
  64. Development of Novel Therapies or Methamphetamine Abuse
    Linda Dwoskin; Fiscal Year: 2009
    ..as a competitive supplement to our current R01 grant DA 13519, titled "Development of Novel Therapies for Methamphetamine Abuse" (FOA is PA07070). Currently, there is no treatment available for methamphetamine abuse...
  65. Neural mechanisms of the methamphetamine-sensitive circadian oscillator
    DAVID ALEXANDER WOOD; Fiscal Year: 2010
    ..Additional studies have suggested the presence of a Methamphetamine-Sensitive Circadian Oscillator (MASCO) that is also independent of the SCN but whose location in the brain ..
  66. Pilot Trial of Bupropion versus Placebo for Methamphetamine Abuse in Adolescents
    KEITH GREGORY HEINZERLING; Fiscal Year: 2010
    b>Methamphetamine (MA) abuse among adolescents is a significant public health problem that is associated with psychological distress, depressive symptoms, auditory hallucinations, suicidal ideation, and high rates of violent behavior and ..
  67. The Dynamics of Methamphetamine Markets: A Systematic Approach to the Process
    HENRY BROWNSTEIN; Fiscal Year: 2009
    ..by applicant): The explicit purpose of this research is to contribute to our knowledge and understanding of methamphetamine markets in terms of their organization and operation. The specific aim is to study market dynamics...
  68. New Dopamine Transporter MRI Nanoprobes for Addiction Research
    Gordana Vitaliano; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Methamphetamine (METH) abuse and dependence represent major mental health and law enforcement problems in the US and abroad...
  69. SLEEP HOMEOSTASIS AND STIMULANT DRUGS OF ABUSE
    Emmanuel Mignot; Fiscal Year: 2002
    DESCRIPTION (Adapted from applicant's abstract): Methamphetamine and cocaine are powerful stimulant drugs of abuse that act, in large part, by increasing dopaminergic transmission in the brain...
  70. Lipid biosignatures of drug addiction
    Daniele Piomelli; Fiscal Year: 2010
    ..through an unbiased evaluation of the lipidome, abnormalities in lipid function that might be involved in methamphetamine self-administration in rats (a model for human addiction) and identify peripheral biomarker candidates that ..