amphetamines

Summary

Summary: Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.

Top Publications

  1. ncbi Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey
    Sean Esteban McCabe
    University of Michigan, Substance Abuse Research Center, Ann Arbor, MI 48105, USA
    Addiction 100:96-106. 2005
  2. ncbi Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry
    Markus R Meyer
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421 Homburg Saar, Germany
    Anal Bioanal Chem 397:1225-33. 2010
  3. ncbi Mechanisms of neurotransmitter release by amphetamines: a review
    David Sulzer
    Department of Psychiatry, Neurology and Pharmacology, New York State Psychiatric Institute, Columbia University, 650 W 168th Street, Black Building Room 309, New York, NY 10032, USA
    Prog Neurobiol 75:406-33. 2005
  4. pmc The N terminus of monoamine transporters is a lever required for the action of amphetamines
    Sonja Sucic
    Center of Biomolecular Medicine and Pharmacology, Institute of Pharmacology, Medical University Vienna, A 1090 Vienna, Austria
    J Biol Chem 285:10924-38. 2010
  5. ncbi The pharmacology and clinical outcomes of amphetamines to treat ADHD: does composition matter?
    Paul Hodgkins
    Shire Pharmaceuticals, Wayne, PA, USA
    CNS Drugs 26:245-68. 2012
  6. ncbi Comparison of immune functional parameters following in vitro exposure to natural and synthetic amphetamines
    R V House
    IIT Research Institute, Chicago, IL 60616
    Immunopharmacol Immunotoxicol 16:1-21. 1994
  7. ncbi Methcathinone: a new postindustrial drug
    Hafid Belhadj-Tahar
    Groupe Santé Recherche, 35 rue Bernard de Ventadour, 31300 Toulouse, France
    Forensic Sci Int 153:99-101. 2005
  8. ncbi New insights into the mechanism of action of amphetamines
    Annette E Fleckenstein
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA
    Annu Rev Pharmacol Toxicol 47:681-98. 2007
  9. ncbi The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine
    Thomas Steinkellner
    Centre for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Wahringerstrasse 13A, A 1090 Vienna, Austria
    Biol Chem 392:103-15. 2011
  10. ncbi Effects of 5-HT2A receptor stimulation and blocking on immune response
    S M Davydova
    Laboratory of Neurochemical Modulation Mechanisms, Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia
    Bull Exp Biol Med 150:219-21. 2010

Detail Information

Publications240 found, 100 shown here

  1. ncbi Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey
    Sean Esteban McCabe
    University of Michigan, Substance Abuse Research Center, Ann Arbor, MI 48105, USA
    Addiction 100:96-106. 2005
    ..To examine the prevalence rates and correlates of non-medical use of prescription stimulants (Ritalin, Dexedrine or Adderall) among US college students in terms of student and college characteristics...
  2. ncbi Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry
    Markus R Meyer
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421 Homburg Saar, Germany
    Anal Bioanal Chem 397:1225-33. 2010
    ..and their metabolites in urine of rats treated with doses corresponding to those reported for abuse of amphetamines. Besides macro-based data evaluation, an automated evaluation using the automated mass spectral deconvolution ..
  3. ncbi Mechanisms of neurotransmitter release by amphetamines: a review
    David Sulzer
    Department of Psychiatry, Neurology and Pharmacology, New York State Psychiatric Institute, Columbia University, 650 W 168th Street, Black Building Room 309, New York, NY 10032, USA
    Prog Neurobiol 75:406-33. 2005
    Amphetamine and substituted amphetamines, including methamphetamine, methylphenidate (Ritalin), methylenedioxymethamphetamine (ecstasy), and the herbs khat and ephedra, encompass the only widely administered class of drugs that ..
  4. pmc The N terminus of monoamine transporters is a lever required for the action of amphetamines
    Sonja Sucic
    Center of Biomolecular Medicine and Pharmacology, Institute of Pharmacology, Medical University Vienna, A 1090 Vienna, Austria
    J Biol Chem 285:10924-38. 2010
    ..In addition, it is the site of action of antidepressants (which block the transporter) and of amphetamines (which induce substrate efflux)...
  5. ncbi The pharmacology and clinical outcomes of amphetamines to treat ADHD: does composition matter?
    Paul Hodgkins
    Shire Pharmaceuticals, Wayne, PA, USA
    CNS Drugs 26:245-68. 2012
    ....
  6. ncbi Comparison of immune functional parameters following in vitro exposure to natural and synthetic amphetamines
    R V House
    IIT Research Institute, Chicago, IL 60616
    Immunopharmacol Immunotoxicol 16:1-21. 1994
    The potential of synthetic and natural amphetamines to modulate cellular immune effector and regulatory mechanisms was evaluated in an in vitro exposure system...
  7. ncbi Methcathinone: a new postindustrial drug
    Hafid Belhadj-Tahar
    Groupe Santé Recherche, 35 rue Bernard de Ventadour, 31300 Toulouse, France
    Forensic Sci Int 153:99-101. 2005
    ..167 g/dL. Urinalysis revealed the presence of benzodiazepines and a high concentration of amphetamines (methcathinone: 17.24 mg/L, ephedrine: 11.60 mg/L and methylephedrine: 11.10 mg/L)...
  8. ncbi New insights into the mechanism of action of amphetamines
    Annette E Fleckenstein
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA
    Annu Rev Pharmacol Toxicol 47:681-98. 2007
    ..All of these mechanisms have potential implications for both amphetamine- and methamphetamine-induced neurotoxicity, as well as dopaminergic neurodegenerative diseases...
  9. ncbi The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine
    Thomas Steinkellner
    Centre for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Wahringerstrasse 13A, A 1090 Vienna, Austria
    Biol Chem 392:103-15. 2011
    ..Here, we attempt to review amphetamine toxicity and in particular MDMA toxicity in the pathogenesis of exemplary human pathologies, independently of confounding environmental factors such as poly-drug use and drug purity...
  10. ncbi Effects of 5-HT2A receptor stimulation and blocking on immune response
    S M Davydova
    Laboratory of Neurochemical Modulation Mechanisms, Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia
    Bull Exp Biol Med 150:219-21. 2010
    ..These data indicate the involvement of 2A serotonin receptors in immunosuppressive mechanisms of serotoninergic system...
  11. pmc Neurotoxicity of drugs of abuse--the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Dialogues Clin Neurosci 11:305-17. 2009
    ..When given in high doses both MDMA and the stimulant amphetamines are clearly neurotoxic in laboratory animals...
  12. ncbi Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency
    Bangning Yu
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA, USA
    J Pharmacol Exp Ther 327:316-23. 2008
    ....
  13. ncbi The non-competitive NMDA receptor blocker dizocilpine potentiates serotonergic function
    R Dall'olio
    Department of Pharmacology, University of Bologna, Italy
    Behav Pharmacol 10:63-71. 1999
    ....
  14. ncbi Myocardial infarction in an adolescent taking Adderall
    Pritesh J Gandhi
    Massachusetts College of Pharmacy and Health Sciences MCPHS, Cambridge, USA
    Am J Health Syst Pharm 62:1494-7. 2005
  15. pmc Stimulants and cardiovascular events in youth with attention-deficit/hyperactivity disorder
    Mark Olfson
    New York State Psychiatric Institute, New York, NY 10032, USA
    J Am Acad Child Adolesc Psychiatry 51:147-56. 2012
    This study examined associations between stimulant use and risk of cardiovascular events and symptoms in youth with attention-deficit/hyperactivity disorder and compared the risks associated with methylphenidate and amphetamines.
  16. ncbi Illicit use of prescription ADHD medications on a college campus: a multimethodological approach
    Alan D DeSantis
    The Department of Communication, The University of Kentucky, Lexington, KY 40506, USA
    J Am Coll Health 57:315-24. 2008
    ..The authors used quantitative and qualitative methodologies to investigate college students' perceptions and use of illegal Attention Deficit Hyperactivity Disorder (ADHD) stimulants during spring and summer 2006...
  17. ncbi Brain injury associated with widely abused amphetamines: neuroinflammation, neurogenesis and blood-brain barrier
    Ana P Silva
    Laboratory of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Portugal
    Curr Drug Abuse Rev 3:239-54. 2010
    ..This review goes beyond the previously well-documented evidence demonstrating that amphetamines cause neuronal injury...
  18. ncbi Amphetamine neurotoxicity: cause and consequence of oxidative stress
    Bryan K Yamamoto
    Department of Pharmacology, Laboratory of Neurochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Crit Rev Neurobiol 17:87-117. 2005
    Oxidative stress has been demonstrated to occur in response to high doses of substituted amphetamines such as methamphetamine (METH) and 3,4-methlyene-dioxymethamphetamine (MDMA)...
  19. ncbi The use of prescription stimulants to enhance academic performance among college students in health care programs
    Lawrence Herman
    Department of Physician Assistant Studies, New York Institute of Technology, Old Westbury, NY 11568, USA
    J Physician Assist Educ 22:15-22. 2011
    ..The study investigated the specific stimulants being used and the frequency of usage. It also examined the rates of nicotine, alcohol, and drug abuse versus dependence...
  20. ncbi The role of the seventh transmembrane region in high affinity binding of a beta 2-selective agonist TA-2005
    H Kikkawa
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Mol Pharmacol 53:128-34. 1998
    ..These results indicate that Tyr308 is an essential amino acid for high affinity binding of the beta 2-selective agonist TA-2005...
  21. ncbi Peripheral administration of group III mGlu receptor agonist ACPT-I exerts potential antipsychotic effects in rodents
    A Pałucha-Poniewiera
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 55:517-24. 2008
    ..These data demonstrate that ACPT-I is a brain-penetrating compound and illustrates its promising therapeutic role for the treatment of schizophrenia...
  22. ncbi Review article: amphetamines and related drugs of abuse
    Shaun L Greene
    Department of Emergency Medicine, Austin Health and Victorian Poisons Information Service, Melbourne, Victoria, Australia
    Emerg Med Australas 20:391-402. 2008
    ..Discharge of non-admitted patients from the emergency department should only occur once physiological parameters and mental state have returned to normal. All patients should receive education regarding the dangers of amphetamine use...
  23. ncbi Associations between use of cocaine, amphetamines, or psychedelics and psychotic symptoms in a community sample
    N Kuzenko
    Department of Psychiatry, University of Manitoba, Winnipeg, MB, Canada
    Acta Psychiatr Scand 123:466-74. 2011
    To investigate the association between use of cocaine, amphetamines, or psychedelics and psychotic symptoms.
  24. ncbi Evaluation of ephedrine, pseudoephedrine and phenylpropanolamine concentrations in human urine samples and a comparison of the specificity of DRI amphetamines and Abuscreen online (KIMS) amphetamines screening immunoassays
    Peter R Stout
    Aegis Sciences Corporation, 345 Hill Ave, Nashville, TN 37210, USA
    J Forensic Sci 49:160-4. 2004
    ..randomly collected human urine samples from Navy and Marine Corps members were simultaneously screened for amphetamines using the DRI and Abuscreen online immunoassays at a cutoff concentration of 500 ng/mL...
  25. ncbi Simultaneous determination of HFBA-derivatized amphetamines and ketamines in urine by gas chromatography-mass spectrometry
    Hei Hwa Lee
    Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
    J Anal Toxicol 35:162-9. 2011
    ..Upper limits of quantitation were 8000 ng/mL for all amphetamines and 6000 ng/mL for ketamine and norketamine...
  26. pmc Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression
    Erin S Calipari
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Commun 4:2720. 2013
    ....
  27. ncbi Amphetamine, cocaine and cannabinoids use among truck drivers on the roads in the State of Sao Paulo, Brazil
    V Leyton
    University of Sao Paulo, Av Dr Arnaldo, 455, Cerqueira Cesar, 01246 903 Sao Paulo, SP, Brazil
    Forensic Sci Int 215:25-7. 2012
    Drugs are important risk factors for traffic accidents. In Brazil, truck drivers report using amphetamines to maintain their extensive work schedule and stay awake...
  28. ncbi The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons
    João Paulo Capela
    REQUIMTE Rede de Química e Tecnologia, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050 313 Porto, Portugal
    Neurotoxicology 34:254-63. 2013
    ..MDMA or "Ecstasy") and 2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) are hallucinogenic amphetamines with addictive properties...
  29. ncbi Prevalence of psychoactive substances in truck drivers in the Nord-Pas-de-Calais region (France)
    Laurence Labat
    Laboratoire Toxicologie et Génopathies, CHRU de Lille, Av Professeur J Leclercq, 59037 Lille Cedex, France
    Forensic Sci Int 174:90-4. 2008
    ..One thousand truck drivers were studied. Urines were tested for amphetamines, cannabinoids, cocaine, opiates, benzodiazepines, buprenorphine and methadone by immunoassay...
  30. pmc N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux
    Habibeh Khoshbouei
    Department of Molecular Physiology and Biophysics and Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee, USA
    PLoS Biol 2:E78. 2004
    ..These data raise the therapeutic possibility of interfering selectively with AMPH-induced DA efflux without altering physiological DA uptake...
  31. ncbi Blockade of the serotonergic system counteracts the dizocilpine-induced changes in dopaminergic function
    R Dall'olio
    Department of Pharmacology, University of Bologna, Italy
    Behav Pharmacol 11:29-36. 2000
    ..The results suggest that the functional integrity of the serotonergic system is fundamental for the occurrence of dopaminergic changes resulting from non-competitive NMDA blockade...
  32. ncbi Cardiovascular safety of ADHD medications: rationale for and design of an investigator-initiated observational study
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 19:934-41. 2010
    ..of an investigator-initiated observational study to examine the cardiovascular safety of the following commonly-used medications to treat attention deficit hyperactivity disorder (ADHD): amphetamines, methylphenidate, and atomoxetine.
  33. pmc Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 220:481-94. 2012
    ..Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity...
  34. ncbi Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry
    Paul D Callaghan
    Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, 78229 3900, USA
    Neurochem Int 47:350-61. 2005
    ..To study the effect of these amphetamines on clearance of 5-HT mediated specifically by the SERT, clearance of exogenously applied 5-HT was measured in ..
  35. ncbi The nonmedical use of prescription stimulants among dental and dental hygiene students
    Amanda D McNiel
    Baylor College of Dentistry, Texas A and M Health Science Center, 3302 Gaston Avenue, Dallas, TX 75246, USA
    J Dent Educ 75:365-76. 2011
    ..These results may help administrators and faculty members become aware of potential problems with the misuse of ADD stimulant medication...
  36. ncbi Amphetamine-induced movement disorder
    Michael A Downes
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, and University of Newcastle, New South Wales, Australia
    Emerg Med Australas 17:277-80. 2005
    Recreational use of amphetamines is common in Australia and New Zealand when compared with other developed nations...
  37. ncbi Evaluating the separation of amphetamines by electrospray ionization ion mobility spectrometry/MS and charge competition within the ESI process
    Laura M Matz
    Department of Chemistry, Washington State University, Pullman 99164 4630, USA
    Anal Chem 74:420-7. 2002
    ..For the first time, we show the separation of six amphetamines by ESI-IMS/MS...
  38. ncbi 24-hour ambulatory blood pressure monitoring in male children receiving stimulant therapy
    Cindy D Stowe
    Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Ann Pharmacother 36:1142-9. 2002
    ..To determine whether cardiac indices are altered as assessed by 24-hour ambulatory blood pressure monitoring (ABPM) in male children receiving either chronic methylphenidate or dextroamphetamine/levoamphetamine (Adderall) therapy...
  39. pmc Identification of prenatal amphetamines exposure by maternal interview and meconium toxicology in the Infant Development, Environment and Lifestyle (IDEAL) study
    Teresa R Gray
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Ther Drug Monit 31:769-75. 2009
    ..Interviews regarding maternal drug use were collected shortly after birth; meconium specimens were screened for amphetamines, cannabis, and cotinine by immunoassay and confirmed by gas chromatography mass spectrometry...
  40. ncbi Use of drugs of abuse in less than 30-year-old drivers killed in a road crash in France: a spectacular increase for cannabis, cocaine and amphetamines
    P Mura
    Laboratoire de Biochimie et Toxicologie, Centre Hospitalier Universitaire, BP 577, 86021 Poitiers, France
    Forensic Sci Int 160:168-72. 2006
    ..was conducted in France in order to determine the prevalence of cannabinoids, opiates, cocaine metabolites and amphetamines in blood samples from drivers killed in road accidents in 2003 and 2004 and to compare these values with those ..
  41. ncbi Do functional relationships exist between 5-HT1A and 5-HT2 receptors?
    N A Darmani
    Department of Pharmacology Toxicology, Virginia Commonwealth University Medical College of Virginia, Richmond 23298
    Pharmacol Biochem Behav 36:901-6. 1990
    ..Taken together with previously published literature data, we propose a 5-HT1A inhibitory action on the 5-HT2 receptor-mediated response when induced by its selective agonist (+/-)-DOI...
  42. ncbi m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors
    S D Gleason
    The Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis 46285, USA
    Behav Pharmacol 12:613-20. 2001
    ....
  43. ncbi Cardiovascular effects of methylphenidate, amphetamines and atomoxetine in the treatment of attention-deficit hyperactivity disorder
    Gary Stiefel
    St Mary s Hospital, London, UK
    Drug Saf 33:821-42. 2010
    ..Drugs such as methylphenidate, amphetamines and atomoxetine are frequently prescribed as part of management...
  44. pmc Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes
    VSEVOLOD KATRITCH
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Mol Recognit 22:307-18. 2009
    ....
  45. ncbi Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons
    G Stumm
    Department of Neuropathology, Institute of Forensic Medicine and Department of Psychiatry, Philipps University, Marburg, Germany
    FASEB J 13:1065-72. 1999
    ..These data support that the neurotoxic effects of different amphetamines are extended to rat neocortical neurons and that apoptotic pathways are involved in amphetamine-induced ..
  46. ncbi Dimethylamylamine: a drug causing positive immunoassay results for amphetamines
    Shawn P Vorce
    Division of Forensic Toxicology, Armed Forces Medical Examiner System, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 102, Rockville, Maryland 20850, USA
    J Anal Toxicol 35:183-7. 2011
    ..DoD) operates six forensic urine drug-testing laboratories that screen close to 5 million urine samples for amphetamines yearly...
  47. ncbi Short-term cardiovascular effects of methylphenidate and adderall
    R L Findling
    Department of Psychiatry and Pediatrics, University Hospitals of Cleveland, Case Western Reserve University, OH 44106-5080, USA
    J Am Acad Child Adolesc Psychiatry 40:525-9. 2001
    ..In addition, under similar conditions, using similar methods, both medication treatments led to changes in blood pressure and pulse that were clinically insignificant...
  48. pmc Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
    Jean Martin Beaulieu
    Howard Hughes Medical Institute, Department of Cell Biology and Center for Models of Human Disease, Institute of Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:5099-104. 2004
    ....
  49. ncbi Stimulating a normal adjustment: misbehavior, amphetamines, and the electroencephalogram at the Bradley Home for children
    Elizabeth Bromley
    Department of Anthropology, University of California, Los Angeles, USA
    J Hist Behav Sci 42:379-98. 2006
    ..The use of amphetamines and the electroencephalogram reorganized concepts of maladjustment along neurological lines, even as the ..
  50. ncbi Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex
    P A Pierce
    Department of Neurology, Stanford University Medical Center, CA 94305
    Psychopharmacology (Berl) 97:118-22. 1989
    ..These rank-order differences in affinities are likely to account for the differing effects of these agents in various biochemical and physiological assays...
  51. ncbi Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism
    R Martin-Ruiz
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    J Neurosci 21:9856-66. 2001
    ..Because pyramidal neurons coexpress 5-HT(1A) and 5-HT(2A) receptors, DOI disrupts the balance between excitatory and inhibitory inputs and leads to an increased activity that may mediate its hallucinogenic action...
  52. ncbi Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:253-9. 2005
    ..To evaluate the effects of medications used in the treatment of adults with attention-deficit/hyperactivity disorder (ADHD) on blood pressure and pulse...
  53. ncbi Selective dopamine D(3) receptor antagonist SB-277011-A potentiates phMRI response to acute amphetamine challenge in the rat brain
    Adam Schwarz
    Department of Neuroimaging, Centre of Excellence for Drug Discovery, Psychiatry, GlaxoSmithKline Medicines Research Centre, 37135 Verona, Italy
    Synapse 54:1-10. 2004
    ..The increased response following D(3) receptor antagonism is consistent with this receptor mediating an inhibitory action on brain activity following a dopaminergic stimulus...
  54. ncbi Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate: a microdialysis study
    Bobby Gough
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 965:410-20. 2002
    ..In the present study, we evaluated the comparative neurotoxicity of substituted amphetamines in rats...
  55. ncbi Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 53:439-52. 2007
    ..These studies identify the long-elusive neural and signaling mechanisms responsible for the unique effects of hallucinogens...
  56. ncbi Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation
    Rob Hameleers
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 185:65-7. 2007
    ..p.) reduced the behavioural activity of the animals and that STN HFS reversed these effects. This study provides the first evidence that the therapeutic effect of STN HFS may also be mediated by a 5-HT-dependent mechanism...
  57. ncbi Performance enhancing, non-prescription use of Ritalin: a comparison with amphetamines and cocaine
    Stanislay I Svetlov
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA
    J Addict Dis 26:1-6. 2007
    ..effects and pharmacological pathways evoked by MPH are similar, but not identical to those produced by amphetamines and cocaine...
  58. ncbi Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses
    Malgorzata Filip
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Pharmacol Exp Ther 310:1246-54. 2004
    ..The present study implies that 5-HT2AR and 5-HT2CR exert oppositional influence upon hyperactivity evoked by acute administration of cocaine; this balance is altered following repeated cocaine administration...
  59. ncbi Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives
    Thomas Kraemer
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, D 66421 Homburg Saar, Germany
    Ther Drug Monit 24:277-89. 2002
    This paper reviews the toxicokinetics of amphetamines. The designer drugs MDA (methylenedioxy-amphetamine, R,S-1-(3;,4;-methylenedioxyphenyl)2-propanamine), MDMA (R,S-methylenedioxymethamphetamine), and MDE (R,S-..
  60. ncbi Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release
    Mahinda Kommalage
    Department of Neuroscience, Division of Comparative Medicine, BMC, Uppsala University, Box 572, S 75123, Uppsala, Sweden
    Eur J Pharmacol 509:127-34. 2005
    ..The results suggest that 5-HT1A and the 5-HT2A receptors are involved in the regulation of acetylcholine release in the spinal cord...
  61. ncbi Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Maebashi, Gunma 371 5811, Japan
    Pain 108:163-9. 2004
    ....
  62. ncbi Effects of amphetamines and small related molecules on recovery after stroke in animals and man
    L B Goldstein
    Box 3651, Duke University Medical Center, Durham, NC 27710, USA
    Neuropharmacology 39:852-9. 2000
    ..The impact of drugs affecting norepinephrine and gamma-aminobutyric acid have been among the most extensively studied in the laboratory, and preliminary clinical data suggest similar effects in humans...
  63. ncbi Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults
    Laurence L Greenhill
    J Am Acad Child Adolesc Psychiatry 41:26S-49S. 2002
    ..Stimulant medications in clinical use include methylphenidate, dextroamphetamine, mixed-salts amphetamine, and pemoline. It carries FDA indications for treatment of attention-deficit/hyperactivity disorder and narcolepsy...
  64. ncbi Neurotransmitter transporters as molecular targets for addictive drugs
    S G Amara
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Drug Alcohol Depend 51:87-96. 1998
    ..Accordingly, it is not surprising that cocaine and amphetamines--some of the most widely used illicit drugs--elevate extraneuronal dopamine concentrations through their ..
  65. ncbi Decreased social behaviour following 3,4-methylenedioxymethamphetamine (MDMA) is accompanied by changes in 5-HT2A receptor responsivity
    Eleanor J Bull
    Institute of Neuroscience, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 46:202-10. 2004
    ....
  66. ncbi A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback control
    Laura J Boothman
    University Department of Pharmacology, Mansfield Road, Oxford, OX1 3QT, UK
    Neuroreport 16:891-6. 2005
    ..These findings suggest that activated local GABA neurons may play an important role in 5-HT2 receptor-mediated feedback control of DRN 5-HT neurons...
  67. ncbi Activation of spinal serotonin(2A/2C) receptors augments nociceptive responses in the rat
    A Kjørsvik
    Department of Physiology and Locus on Neuroscience, University of Bergen, Arstadveien 19, N 5009, Bergen, Norway
    Brain Res 910:179-81. 2001
    ..The findings support the hypothesis that spinal 5-HT(2A/2C) receptors augment the spinal afferent nociceptive impulses induced by peripheral inflammation...
  68. ncbi 3,4-Methylenedioxy analogues of amphetamine: defining the risks to humans
    K M Hegadoren
    Faculty of Nursing, Department of Psychiatry, University of Alberta, Edmonton, Canada
    Neurosci Biobehav Rev 23:539-53. 1999
    ....
  69. ncbi Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test
    M Sasaki
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, 3 39 22 Shouwa machi, Gunma, 371 8511, Maebashi, Japan
    Eur J Pharmacol 424:45-52. 2001
    ..These results suggest that 5-HT2 and 5-HT3 receptors in the spinal cord mediate antinociception to chemical stimuli...
  70. ncbi Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, DHHS NIH NIDA, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Neurotox Res 11:183-202. 2007
    The amphetamines, including amphetamine (AMPH), methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA), are among abused drugs in the US and throughout the world...
  71. ncbi Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport
    Jacob U Fog
    Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Pharmacology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Neuron 51:417-29. 2006
    Efflux of dopamine through the dopamine transporter (DAT) is critical for the psychostimulatory properties of amphetamines, but the underlying mechanism is unclear...
  72. pmc Abuse of amphetamines and structural abnormalities in the brain
    Steven Berman
    Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    Ann N Y Acad Sci 1141:195-220. 2008
    We review evidence that structural brain abnormalities are associated with abuse of amphetamines. A brief history of amphetamine use/abuse and evidence for toxicity is followed by a summary of findings from structural magnetic resonance ..
  73. pmc Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease
    Tatyana D Sotnikova
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 3:e271. 2005
    ..Identification of dopamine transporter- and dopamine-independent locomotor actions of amphetamines suggests a novel paradigm in the search for prospective anti-Parkinsonian drugs.
  74. ncbi Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators
    Mark D Berry
    ALviva Biopharmaceuticals Inc, Saskatoon, Saskatchewan, Canada
    J Neurochem 90:257-71. 2004
    ..These effects are seen as an altered neuronal sensitivity to monoamine neurotransmitters, with no change in neuronal excitability in the absence of neurotransmitter...
  75. ncbi The functioning neuronal transporter for dopamine: kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate
    James O Schenk
    Department of Chemistry, School of Molecular Biosciences, and Program in Pharmacology Toxicology, Washington State University, Pullman, WA 99164 4630, USA
    Prog Drug Res 59:111-31. 2002
    ....
  76. ncbi The role of zinc ions in reverse transport mediated by monoamine transporters
    Petra Scholze
    Institute of Pharmacology, University of Vienna, Wahringerstrasse 13A, A 1090 Vienna, Austria
    J Biol Chem 277:21505-13. 2002
    ..In addition, they indicate a physiological role of Zn2+, because Zn2+ also facilitated transport reversal of DAT in rat striatal slices...
  77. ncbi Simultaneous analysis of six amphetamines and analogues in hair, blood and urine by LC-ESI-MS/MS. Application to the determination of MDMA after low ecstasy intake
    Marjorie Chèze
    Laboratoire TOXLAB, Paris, France
    Forensic Sci Int 170:100-4. 2007
    ..A first sample of urine was collected a few hours after (T+12h) and tested positive to amphetamines by immunoassay by a clinical laboratory...
  78. ncbi Performance characteristics of DRI, CEDIA, and REMEDi systems for preliminary tests of amphetamines and opiates in human urine
    Min Kun Huang
    National Bureau of Controlled Drugs, Department of Health Taiwan, 6 Linsen South Road, Taipei 10050, Taiwan, ROC
    J Anal Toxicol 30:61-4. 2006
    Arrestee urine specimens (930) were tested with DRI, CEDIA, and REMEDi; those that tested positive for amphetamines and opiates (616 and 414, respectively) were then confirmed by gas chromatography-mass spectrometry...
  79. ncbi Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy
    Tatiana Sorkina
    Department of Pharmacology and Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:28274-83. 2003
    ..These data suggest that DAT oligomers are formed in the ER and then are constitutively maintained both at the cell surface and during trafficking between the plasma membrane and endosomes...
  80. ncbi N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents
    Marco Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Italy
    J Neurochem 105:1770-80. 2008
    ..It is worth noting that only those amphetamine derivatives with high efficiency in inducing 5-HT release and currents in vitro have neurotoxic properties...
  81. ncbi Effects of amphetamines on mitochondrial function: role of free radicals and oxidative stress
    Jeffrey M Brown
    Department of Pharmacology and Experimental Therapeutics, L 613, School of Medicine, Boston University, 715 Albany Street, Boston, MA 02118, USA
    Pharmacol Ther 99:45-53. 2003
    ..b>Amphetamines also inhibit mitochondrial function, although the mechanism involved in the inhibition is uncertain...
  82. pmc Effects of clozapine and 2,5-dimethoxy-4-methylamphetamine [DOM] on 5-HT2A receptor expression in discrete brain areas
    M M Doat-Meyerhoefer
    Department of Pharmacology and Toxicology, 102 Farber Hall, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA
    Pharmacol Biochem Behav 81:750-7. 2005
    ..Both chronic treatment with DOM and clozapine decreased the stimulus effects of DOM. The present findings suggest a role for the olfactory nucleus in producing the stimulus effects of DOM...
  83. ncbi Unexpected inhibitory regulation of glutamate release from rat cerebrocortical nerve terminals by presynaptic 5-hydroxytryptamine-2A receptors
    Su Jane Wang
    School of Medicine, Fu Jen Catholic University, Taipei Hsien, Taiwan
    J Neurosci Res 84:1528-42. 2006
    ..These observations invoke presynaptic inhibitory 5-HT(2A) receptor function as a potential target for drugs to mitigate the effects of excessive glutamatergic transmission...
  84. ncbi Recent paramethoxymethamphetamine (PMMA) deaths in Taiwan
    Dong Liang Lin
    Institute of Forensic Medicine, Ministry of Justice, Taipei, Taiwan
    J Anal Toxicol 31:109-13. 2007
    ..from these cases were initially identified by an AxSYM fluorescence polarization immunoassay screening test for amphetamines with a 300 ng/mL cutoff...
  85. ncbi [Behavioral and pharmacological characteristics of mice lacking the dopamine transporter]
    Grazyna Biala
    Katedra Farmakologii z Farmakodynamika Akademii Medycznej im prof F Skubiszewskiego w Lublinie
    Postepy Hig Med Dosw (Online) 58:560-4. 2004
    ..The reinforcing potency of amphetamines, cocaine, and morphine maintained in the absence of the DAT may suggest that other neurotransmitter systems in ..
  86. ncbi Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine
    Jeffrey W Dalley
    Department of Experimental Psychology and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:1195-206. 2007
    ..The demonstration of residual deficits in rats chronically exposed to MDMA raises some concern about the potential harm caused by this drug in human ecstasy users...
  87. ncbi alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons
    Laura Grandoso
    Departamento de Farmacologia, Universidad del Pais Vasco, E 48940 Leioa, Vizcaya, Spain
    Eur J Pharmacol 517:51-8. 2005
    ..alpha(2)-adrenoceptor activation may underlie this effect as a result of elevated levels of noradrenaline in the synaptic cleft...
  88. ncbi Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats
    A Blokland
    Faculty of Psychology, Brain am Behaviour Institute and European Graduate School of Neurosciences, Maastricht University, The Netherlands
    Behav Pharmacol 16:93-100. 2005
    ..Eticlopride did not affect impulsive responding. The present data suggest that 5-HT2A receptors and dopamine (but not D2 receptors) are associated with motor impulsivity...
  89. pmc Cocaine-mediated supersensitivity of 5-HT2A receptors in hypothalamic paraventricular nucleus is a withdrawal-induced phenomenon
    G A Carrasco
    Department of Pharmacology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Neuroscience 143:7-13. 2006
    ....
  90. ncbi Adderall abuse in Texas, 1998-2004
    Mathias B Forrester
    Epidemiology and Disease Surveillance Unit, Texas Department of State Health Services, Austin, Texas 78756, USA
    J Toxicol Environ Health A 70:658-64. 2007
    ..48%). Adderall abusers are more likely to be adolescents. Adderall abuse as compared to other exposures is more likely to occur outside of the person's home and involve more serious medical outcomes...
  91. ncbi Microarray studies of psychostimulant-induced changes in gene expression
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Addict Biol 10:101-18. 2005
    ....
  92. ncbi New risks for pulmonary hypertension: need for a large epidemiologic study
    Elisabeth D Willers
    Chest 130:1633-5. 2006
  93. ncbi Rapid simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine in urine by fast gas chromatography-mass spectrometry
    Kevin L Klette
    Navy Drug Screening Laboratory, 320B B Street, Great Lakes, Illinois 60088 2815, USA
    J Anal Toxicol 29:669-74. 2005
    ....
  94. ncbi Date-rape drugs scene in Poland
    Piotr Adamowicz
    Department of Forensic Toxicology, The Prof Dr J Sehn Institute of Forensic Research, Krakow, Poland
    Przegl Lek 62:572-5. 2005
    ..36-1.4 ng/ml). Alcohol (0.27-2.3% per hundred), MDMA (8-201 ng/ml), benzodiazepines (oxazepam, nordazepam, estazolam), propranolol and lidocaine were also found in blood and urine specimens...
  95. ncbi From attention-deficit/hyperactivity disorder to medical stimulant use to the diversion of prescribed stimulants to non-medical stimulant use: connecting the dots
    Christiane Poulin
    Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Addiction 102:740-51. 2007
    ....
  96. ncbi Roadside oral fluid testing: comparison of the results of drugwipe 5 and drugwipe benzodiazepines on-site tests with laboratory confirmation results of oral fluid and whole blood
    Anna Pehrsson
    National Public Health Institute, Drug Research Unit, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Forensic Sci Int 175:140-8. 2008
    ..The results of the performance evaluations were: for oral fluid (sensitivity; specificity; accuracy) amphetamines (95.5%; 92.9%; 95.3%), cannabis (52.2%; 91.2%; 85.1%), cocaine (50.0%; 99.3%; 98.6%), opiates (100%; 95.8%; 95...
  97. ncbi Results of hair analyses for drugs of abuse and comparison with self-reports and urine tests
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 156:118-23. 2006
    ..well as head and pubic hair samples from drug abusers were analysed for opiates, cocaine and its metabolites, amphetamines, methadone and cannabinoids...
  98. ncbi Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex
    Elizabeth A Pehek
    Department of Psychiatry, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Neuropsychopharmacology 31:265-77. 2006
    ..These findings may have implications for the pharmacological treatment of disorders resulting from or exacerbated by stress...
  99. ncbi Discriminative stimulus and reinforcing effects of p-fluoro-L-deprenyl in monkeys
    Sevil Yasar
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 182:95-103. 2005
    ..para-Fluoro-L-deprenyl (Fludepryl), a halogenated derivative of L-deprenyl, shares structural similarities with amphetamine and may have potential as a medication for psychostimulant abuse...
  100. ncbi Differentiation between drug use and environmental contamination when testing for drugs in hair
    Lolita Tsanaclis
    TrichoTech, No 1 Pentwyn Business Centre, Cardiff CF23 7HB, United Kingdom
    Forensic Sci Int 176:19-22. 2008
    ....
  101. ncbi Pharmacological and behavioral determinants of cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, and para-methoxyamphetamine-induced hyperthermia
    Emily Joy Jaehne
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Level 5 Medical School North, Adelaide, South Australia 5005, Australia
    Psychopharmacology (Berl) 194:41-52. 2007
    ..Harm minimization advice on how to prevent overheating depends on appropriate thermoregulatory behavior by drug users...

Research Grants63

  1. Dopamine Transporter Structure and Function
    Christopher K Surratt; Fiscal Year: 2010
    ..that the DAT is the brain receptor chiefly responsible for the reward/reinforcing properties of cocaine and the amphetamines. The protein is further implicated in a host of CNS disorders...
  2. CNS circuitry and receptors mediating the effects of MDMA
    Daniel E Rusyniak; Fiscal Year: 2013
    ..the central pathways and mechanisms responsible for toxicity associated with the use of substituted amphetamines provides the necessary framework for rational treatment and prevention strategies...
  3. MONOAMINE AND HALLUCINOGEN EFFECTS ON RODENT BEHAVIOR
    Mark A Geyer; Fiscal Year: 2013
    ..underlying the behavioral effects of synthetic hallucinogenic drugs of abuse, including LSD and substituted amphetamines, and hallucinogenic natural products used in recreational, ritual, or religious contexts, including psilocybin ..
  4. Ethanol-induced conditioned partner preference in mice
    Ruth I Wood; Fiscal Year: 2013
    ..Aim 2 will expand the conditioned partner preference model to test the effects of other drugs of abuse (amphetamines, morphine) on social bonding...
  5. Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/Disorder
    Drake Morgan; Fiscal Year: 2013
    ..abstract_text> ..
  6. Cardiovascular Risks of Prescription Amphetamine Use in a National Veterans Study
    ARTHUR WESTOVER; Fiscal Year: 2013
    ..provided by applicant): Currently there are tremendous gaps in our knowledge of who is being prescribed amphetamines, for what indications, and their long term cardiovascular safety...
  7. Non-Tropane Irreversible Dopamine Transporter Ligands
    DAVID JOHN LAPINSKY; Fiscal Year: 2010
    ..indicate is the brain receptor chiefly responsible for the reinforcing / reward properties associated with amphetamines and cocaine...
  8. Amphetamine Acts as a Molecular Stent in the Dopamine Transporter
    Louis J De Felice; Fiscal Year: 2010
    ..addiction as a basis for drug discovery, we propose a new concept suggested by new experimental evidence that amphetamines lodge in transporter and open a pathway for ions that is not ordinarily there, and that the currents thus ..
  9. Small Molecule Libraries Targeted to CBP and Attenuation AfosB Expression
    Ming Ming Zhou; Fiscal Year: 2013
    ..Thus exposure to drugs of abuse such cocaine and amphetamines have been shown to lead to increase FosB protein expression in cells of the nucleus accumbens...
  10. Community Vulnerability and Responses to Drug-User-Related HIV/AIDS
    Samuel R Friedman; Fiscal Year: 2013
    ..as others have shown, HIV has spread widely among NIDUs (non-injecting users of heroin, cocaine, crack, amphetamines or methamphetamine) in some metropolitan areas...
  11. Intermittent Naltrexone among Polysubstance Users
    Glenn Milo Santos; Fiscal Year: 2013
    ..Naltrexone has shown efficacy in reducing relapse to amphetamines and is FDA-approved for alcohol dependence...
  12. Neural and Cognitive Correlates of Methamphetamine Use in Schizophrenia
    RUTH EILEEN SALO; Fiscal Year: 2012
    ..the use of the stimulant methamphetamine (MA) has increased in the general population, with worldwide abuse of amphetamines surpassing that of cocaine and opiates combined...
  13. The Role of the Activity-Regulated GTPase Rem2 in Dendrite Development
    AMY ELIZABETH GHIRETTI; Fiscal Year: 2013
    ..the changes in neuronal activity that occur in response to the administration of drugs such as cocaine, amphetamines, nicotine, and opiates...
  14. Physiological Implications of Serotonin Receptor Regulation
    Laura M Bohn; Fiscal Year: 2013
    ..Other drugs of abuse that indirectly act at the 2A receptor are amphetamines, particularly MDMA or "ecstacy"...
  15. Methamphetamine &Amphetamine Differentially Affect Dopamine Transporter Activity
    Habibeh Khoshbouei; Fiscal Year: 2013
    ..similarities regulation of dopamine transporter (DAT) is generally inferred from studies characterizing other amphetamines. Our proposed studies 1) will clarify the molecular mechanisms of methamphetamine-induced dopamine efflux via ..
  16. METHAMPHETAMINE ABUSE AND CORTICAL CELL INJURY
    JOHN FOSTER MARSHALL; Fiscal Year: 2012
    ..by applicant): Although psychostimulant drug abuse poses several potential health risks, the chronic abuse of amphetamines carries the danger of permanent brain injury...
  17. Hepatic Metabolism and Susceptibility to Ecstasy Toxicity
    Terrence J Monks; Fiscal Year: 2012
    ..the brain fails to reproduce the neurotoxicity following peripheral administration, indicating that the parent amphetamines are unlikely to be solely responsible for the neurotoxic effect...
  18. Discovery of Bifunctional NOP/Opioid Receptor Ligands for Drug Abuse Therapy
    Nurulain T Zaveri; Fiscal Year: 2013
    ..acquisition of conditioned place preference (CPP) to several drugs of abuse;in particular, morphine, cocaine, amphetamines, and alcohol...
  19. Pharmacogenetics of Natlrexone for Methamphetamine Use Disorder
    Lara Ray; Fiscal Year: 2013
    ..for MA dependence remain elusive despite extensive research on the neurobiology of the effects of amphetamines. Naltrexone (NTX) is an opioid receptor antagonist with empirically supported efficacy and FDA-approval for the ..
  20. Synthetic cathinones: a new class of illicit drugs affecting DAT &SERT
    SIDNEY S NEGUS; Fiscal Year: 2013
    ..One of our objectives, therefore, is to codify structural varians of the [unreadable]-keto amphetamines (synthetic cathinones) that will predict their effects and speed societal and scientific responses to compounds ..
  21. Naltrexone for the treatment of Actively-Using Met-Dependent MSM with High-Risk B
    Susan Buchbinder; Fiscal Year: 2013
    ..Globally, use of amphetamines is more common than heroin and opioids, with an estimated 16 to 51 million users worldwide and 1...
  22. Preventing Drug Use in Low Income Clinic Populations
    LILLIAN GELBERG GELBERG; Fiscal Year: 2011
    ..For this small trial, we will sample patients with `at risk'use of stimulants (cocaine or amphetamines), the most commonly used serious drugs among patients at our clinic sites...
  23. Structure and Function of Neurotransmitter Transporters
    James E Gouaux; Fiscal Year: 2013
    ..a wide array of illicit compounds that modulate transporter function, including antidepressants, cocaine and amphetamines. At most chemical synapses, the removal of transmitter is accomplished by integral membrane proteins called ..
  24. Non-invasive Blood Alcohol Sensor for Emergency Room Applications
    MANAL BESHAY; Fiscal Year: 2013
    ..levels, introduce a method for quantitative (high/mid/low) measurement of six drugs of abuse (opiates, cocaine, amphetamines, THC, benzodiazepines, barbiturates), and develop the portable readout system...
  25. Pawhuskins: Potential Treatments for Stimulant Abuse.
    Jeffrey D Neighbors; Fiscal Year: 2010
    Stimulant abuse (including both cocaine and amphetamines) is a serious public health problem...
  26. Gestational Age Variation in Human Placental Transport Mechanisms
    Sammanda Ramamoorthy; Fiscal Year: 2013
    ..From our clinical population, paired maternal/fetal samples will be collected in women using amphetamines and escitalopram across gestation to assess exposure to our model substrates (Specific Aim #3)...
  27. Imaging Individual Differences in Amphetamine Effects
    Tara L White; Fiscal Year: 2010
    ..Response to amphetamines, which tends to be stable over time, appears to be modulated by personality and gender...
  28. Does amphetamine use impair brain systems in OEF/OIF veterans with PTSD?
    Martin P Paulus; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Amphetamines are among the most widely used illicit drugs worldwide and in the U.S...
  29. Career Development Award
    ANNETTE FLECKENSTEIN; Fiscal Year: 2013
    ..transporter-2 (\/MAT-2) regulation and function, especially as related to the neurotoxic effects of the amphetamines. The applicant is a current K02 recipient, and this has permitted the applicant to dramatically decrease her ..
  30. Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine Abuse
    Craig R Rush; Fiscal Year: 2013
    ..g., oxazepam [OXP]) and opioid antagonists (e.g., naltrexone [NTX]) attenuate the abuse-related effects of amphetamines. The attenuation of the abuse-related effects of amphetamine by GABAA receptor modulators or opioid antagonists,..
  31. MECHANISMS OF ACTIVE NEUROTRANSMITTER TRANSPORT
    Shimon Schuldiner; Fiscal Year: 2013
    ..for their central role is that they are the targets of many psychoactive drugs, such as Prozac, Cocaine and Amphetamines, and that their malfunctioning leads to severe pathological conditions...
  32. MyStudentBody-Community College: A Health Website for Students
    ELIZABETH ANNA DONOVAN; Fiscal Year: 2010
    ..many students binge drink, and there are particularly high rates of smoking, and use of marijuana, cocaine and amphetamines. Consequences for students include increased disease risk as well as an even more difficult learning experience...
  33. Neural Sensitivity to Stress During Drug Withdrawal
    Gina L Forster; Fiscal Year: 2013
    ..methamphetamine as the second most widely abused illicit drug after marijuana, and abuse of prescription amphetamines in the US is increasing...
  34. Ion and Biogenic Amine Transport Mechanism
    GARY W RUDNICK; Fiscal Year: 2013
    ..Within the family containing neurotransmitter transporters that are targets of cocaine and amphetamines, a bacterial protein (LeuT) has been crystallized in complex with several substrates and drugs...
  35. Negative reinforcement and interoceptive dysfunction in stimulant dependence.
    Martin P Paulus; Fiscal Year: 2013
    Abstract After marijuana, amphetamines are the most widely used illicit drug class worldwide. A recent report estimates that methamphetamine causes about 895 deaths per year in the U.S...
  36. Imaging Dopamine Mediated Neurovascular Coupling
    Bruce Jenkins; Fiscal Year: 2010
    ..dopamine receptor sub-types will have on the hemodynamic changes elicited by drugs of abuse such as cocaine and amphetamines. Then we will assay how these receptor sub-types change in two different models of dopaminergic modulation...
  37. Early Drug Exposure and Drug Reward Mechanisms
    Susan L Andersen; Fiscal Year: 2013
    ..g. methylphenidate (MPH), amphetamines) lies in their ability to reduce abnormalities in prefrontal dopamine function...
  38. Monoamine Transporter Structure-Function Studies
    CHRISTOPHER SURRATT; Fiscal Year: 2007
    ..DAT) is the brain receptor chiefly responsible for the reward/reinforcing properties of cocaine and the amphetamines. The serotonin transporter protein (SERT) also plays a key role in the mood-altering effects of these drugs, ..
  39. MECHANISMS OF DRUG DEPOSITION IN HAIR
    JAMES RUTH; Fiscal Year: 2002
    ..with possible covalent incorporation into hair matrix; (4) studies with fentanyl (as opposed to [H-3]-d-amphetamines and a benzoyl esterified amino alcohol, a model of cocaine) demonstrated that systemic delivery was not dose ..
  40. Clinical Efficacy of Lisdexamfetamine for Methamphetamine Dependence
    Michael J Mancino; Fiscal Year: 2013
    ..including the potential for abuse, psychosis and neurotoxic effects associated with prolonged exposure to amphetamines. Thus, given the potential for alleviating withdrawal utilizing a short term agonist therapy, this proposal ..
  41. DIAGNOSTIC VIABILITY OF UMBILICAL CORD SPECIMENS
    Charles Plate; Fiscal Year: 2007
    ..During the Phase I study we screened 118 matched meconium/umbilical cord samples with immunoassays specific for amphetamines, opiates, cocaine metabolites, cannabinoids, and phencyclidine (PCP) (NIDA-5 panel)...
  42. Clinical Pharmacology of 3,4-Methylenedioxy Amphetamines
    John E Mendelson; Fiscal Year: 2010
    ..This experiment will investigate the role of alpha-1 adrenergic receptors in the action of MDMA and will provide preliminary data on the possible use of prazosin in the treatment of acute MDMA toxicity. ..
  43. PSYCHOMOTOR STIMULANTS AND ADRENERGIC NERVE FUNCTION
    Charles Smith; Fiscal Year: 1991
    ..pharmacological actions of psychotropic drugs, especially those psychomotor stimulants such as cocaine and the amphetamines which are known to release catecholamines from neurons and block neurotransmitter reuptake; 2) long-term ..
  44. TAS::75 0893::TAS SYNTHESIS AND DISTRIBUTION OF OPIOID AND RELATED PEPTIDES
    JEANICK PASCAL; Fiscal Year: 2011
    ..and chemicals include marijuana and marijuana cigarettes, various cannabinoids, known hallucinogens, heroin, amphetamines, and many others that are essential for pre-clinicla and clinical research...
  45. Structure and Function of Neurotransmitter Transporters
    JAMES GOUAUX; Fiscal Year: 2009
    ..a wide array of illicit compounds that modulate transporter function, including antidepressants, cocaine and amphetamines. At most chemical synapses, the removal of transmitter is accomplished by integral membrane proteins called ..
  46. 38th Annual International Narcotics Research Conference
    Jean Bidlack; Fiscal Year: 2007
    ..still opiate drugs and abuse, there is increasing discussion of other abused drugs, such as marijuana, cocaine, amphetamines, and alcohol, since extensively interactions between these drugs and the endogenous opioid system has been ..
  47. COCAINE, MARIHUANA AND PHENCYCLIDINE INTERACTIONS
    Syed Husain; Fiscal Year: 1990
    ..has been accompanied by a corresponding increase in the use of drugs such as marihuana, phencyclidine (PCP), amphetamines, methaqualones and others...
  48. CATECHOLAMINES, ANTIOXIDANTS AND OXIDATIVE STRESS
    Kandatege Wimalasena; Fiscal Year: 2003
    ..and central nervous system diseases such as Parkinson's Disease, as well as in the use of illicit drugs such as amphetamines have been attributed to the catecholamine mediated excessive production of oxygen free radicals and/or H2O2 in ..
  49. ISOQUINOLINE B3 AR AGONISTS AS ANTIOBESITY AGENTS
    DENNIS FELLER; Fiscal Year: 1999
    ..In the 1960's and 1970's amphetamines were the drug of choice, but they caused many problems including addiction...
  50. METABOLISM AS A FACTOR IN DRUG-INDUCED NEUROTOXICITY
    TERRENCE MONKS; Fiscal Year: 1999
    ..Both drugs are ring-substituted amphetamine derivatives structurally related to psychomotor stimulant amphetamines and the hallucinogen mescaline...
  51. Cocaine-Induced Epigenetic Changes in CD4+ T cells and HIV-1 Replication
    Chandravanu Dash; Fiscal Year: 2011
    ..Illicit drugs such as amphetamines, cocaine, marijuana, and opiates serve as cofactors for susceptibility to HIV infection and disease progression...
  52. Translational Genetics and Dopamine Signaling in Sensitivity to Amphetamines
    CAMRON BRYANT; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Abuse of amphetamines is a major public health problem that warrants the identification of genetic risk factors which could lead to addiction prevention and novel treatments...
  53. K OPIOIDS AND DOPAMINE--MECHANISMS OF STIMULANT ABUSE
    Sari Izenwasser; Fiscal Year: 2001
    ..dopamine transporter, cocaine by inhibiting dopamine uptake (the inward flow of dopamine into the neuron), and amphetamines by stimulating dopamine release via reversal of the transporter...
  54. SLEEP HOMEOSTASIS AND STIMULANT DRUGS OF ABUSE
    Emmanuel Mignot; Fiscal Year: 2002
    ..cocaine, produce no CSR, suggesting interactions with sleep homeostatic mechanisms that are distinct from amphetamines. Cholinergic neurons in the nucleus basalis (NBM), nucleus accumbens, and adjacent regions receive dopaminergic ..
  55. SYNTHETIC PEPTIDES PURITY DETERMINATION, STABILITY TEST
    KANTHI HETTIARACHCHI; Fiscal Year: 2000
    ..These include known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory research studies...
  56. DRUG ABUSE BY PREGNANT WOMEN & NEW FATHERS-NATL ANALYSIS
    TONI RICHARDS; Fiscal Year: 1990
    ..the periods 1979-84 and 1986-88 (for marijuana use), 1983-84 and 1986-88 (for cocaine use), and 1983-84 (for amphetamines and other drugs)...
  57. NOVEL ANTI-PCP AGENTS WITH NEUROPROTECTIVE PROPERTIES
    TIEN HUANG; Fiscal Year: 2001
    ..For instance, AIDS dementia and abuse of stimulants (e.g. amphetamines and cocaine) are associated with neurotoxicity presumably caused by activation of the N-methyl-D-aspartate (..
  58. SYNTHETIC PEPTIDES AS STRUCTURAL PROBES FOR PRECLINICAL
    GEORGE BRINE; Fiscal Year: 2000
    ..These include marijuana cigarettes, known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory research studies...
  59. CB1 receptor in medium spiny neurons in amphetamine sensitization
    BRIAN ROBERT HAAS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Drug addiction, including to amphetamines and their derivatives, cost the United States approximately $181 billion each year...
  60. SYNTHESIS AND DISTRIBUTION OF OPIOID & RELATED PEPTIDES
    Richard Houghten; Fiscal Year: 2000
    ..These include marijuana cigarettes, known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory -research studies...
  61. CELLULAR TARGETS FOR ABUSABLE DRUGS IN HUMAN PLACENTA
    Vadivel Ganapathy; Fiscal Year: 1999
    ..is to investigate the role of placenta in the pathogenesis of complications arising from abuse of cocaine and amphetamines during pregnancy and to establish that placenta is a direct target for these drugs...
  62. DRUGS OF ABUSE IN SEROTONIN RECEPTORS KNOCKOUT MICE
    Rene Hen; Fiscal Year: 2003
    ..neural circuits to the rewarding and stimulating effects of two families of drugs of abuse: substituted amphetamines (MDMA) and psychostimulants (cocaine)...
  63. SUBSTITUTED AMPHETAMINE NEUROTOXICITY
    George Ricaurte; Fiscal Year: 2003
    ..Additionally, this research seeks to identify the mechanism by which substituted amphetamines damage brain aminergic neurons, as this information may yield insight into the processes underlying neuronal ..