histamine

Summary

Summary: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Top Publications

  1. doi Histamine in the nervous system
    Helmut L Haas
    Institute of Neurophysiology, Heinrich Heine University, Duesseldorf, Germany
    Physiol Rev 88:1183-241. 2008
  2. doi Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs
    Andrea Strasser
    Department of Pharmaceutical Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
    Trends Pharmacol Sci 34:13-32. 2013
  3. pmc Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:4687-92. 2006
  4. ncbi The role of histamine and the tuberomamillary nucleus in the nervous system
    Helmut Haas
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Nat Rev Neurosci 4:121-30. 2003
  5. pmc Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling
    Carissa M Thomas
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e31951. 2012
  6. pmc Sensory responses to injection and punctate application of capsaicin and histamine to the skin
    Parul Sikand
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Pain 152:2485-94. 2011
  7. pmc Arousal effect of orexin A depends on activation of the histaminergic system
    Z L Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    Proc Natl Acad Sci U S A 98:9965-70. 2001
  8. pmc Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent
    Jianfeng Dai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    PLoS Pathog 6:e1001205. 2010
  9. doi The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish
    Maria Sundvik
    Neuroscience Center and Institute of Biomedicine, Anatomy, Faculty of Medicine, P O B 63, 00014 University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
    FASEB J 25:4338-47. 2011
  10. doi Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice
    Saara Nuutinen
    Neuroscience Center, Institute of Biomedicine Anatomy, Biomedicum Helsinki, University of Helsinki, P O Box 63, Haartmaninkatu 8, Helsinki, FIN 00014, Finland
    Psychopharmacology (Berl) 208:75-86. 2010

Detail Information

Publications367 found, 100 shown here

  1. doi Histamine in the nervous system
    Helmut L Haas
    Institute of Neurophysiology, Heinrich Heine University, Duesseldorf, Germany
    Physiol Rev 88:1183-241. 2008
    b>Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the skin, and the immune system...
  2. doi Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs
    Andrea Strasser
    Department of Pharmaceutical Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
    Trends Pharmacol Sci 34:13-32. 2013
    b>Histamine is a biogenic amine that exerts its biological effects as a neurotransmitter and local mediator via four histamine receptor (HR) subtypes (H(x)Rs) - H(1)R, H(2)R, H(3)R, and H(4)R - belonging to the superfamily of G-protein-..
  3. pmc Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:4687-92. 2006
    Histaminergic neurons play an important role in the regulation of sleep-wake behavior through histamine H(1) receptors (H(1)R)...
  4. ncbi The role of histamine and the tuberomamillary nucleus in the nervous system
    Helmut Haas
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Nat Rev Neurosci 4:121-30. 2003
  5. pmc Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling
    Carissa M Thomas
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e31951. 2012
    ..b>Histamine was identified and quantified in TNF-inhibitory HILIC-HPLC fractions...
  6. pmc Sensory responses to injection and punctate application of capsaicin and histamine to the skin
    Parul Sikand
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Pain 152:2485-94. 2011
    A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis)...
  7. pmc Arousal effect of orexin A depends on activation of the histaminergic system
    Z L Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    Proc Natl Acad Sci U S A 98:9965-70. 2001
    ..Here we provide several lines of evidence that orexin A induces wakefulness by means of the TMN and histamine H(1) receptor (H1R)...
  8. pmc Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent
    Jianfeng Dai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    PLoS Pathog 6:e1001205. 2010
    ..In this study, we characterized a tick histamine release factor (tHRF) from Ixodes scapularis and addressed the vaccine potential of this antigen in the context ..
  9. doi The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish
    Maria Sundvik
    Neuroscience Center and Institute of Biomedicine, Anatomy, Faculty of Medicine, P O B 63, 00014 University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
    FASEB J 25:4338-47. 2011
    ..We elucidated the role of histamine in wakefulness and the interaction of the histamine and hcrt systems in larval zebrafish...
  10. doi Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice
    Saara Nuutinen
    Neuroscience Center, Institute of Biomedicine Anatomy, Biomedicum Helsinki, University of Helsinki, P O Box 63, Haartmaninkatu 8, Helsinki, FIN 00014, Finland
    Psychopharmacology (Berl) 208:75-86. 2010
    Neuronal histamine has a prominent role in sleep-wake control and body homeostasis, but a number of studies suggest that histamine has also a role in higher brain functions including drug reward.
  11. pmc In vivo electrochemical evidence for simultaneous 5-HT and histamine release in the rat substantia nigra pars reticulata following medial forebrain bundle stimulation
    Parastoo Hashemi
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurochem 118:749-59. 2011
    ..methods and describe physiological, anatomical and independent chemical analyses to identify this species as histamine. We also show pharmacologically that increasing the lifetime of extracellular histamine significantly decreases ..
  12. doi Expression of toll-like receptor 2, NOD2 and dectin-1 and stimulatory effects of their ligands and histamine in normal human keratinocytes
    M Kobayashi
    Department of Dermatology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Br J Dermatol 160:297-304. 2009
    ..However, few studies have examined the function and expression of innate immune proteins in keratinocytes. Histamine, which is well known for itch and allergy, is closely associated with innate immunity, but its influence on ..
  13. pmc Histamine-producing pathway encoded on an unstable plasmid in Lactobacillus hilgardii 0006
    Patrick M Lucas
    Faculté d Oenologie, UMR 1219, INRA Université Victor Segalen Bordeaux 2, 351, Cours de la Liberation, 33405 Talence, France
    Appl Environ Microbiol 71:1417-24. 2005
    b>Histamine production from histidine in fermented food products by lactic acid bacteria results in food spoilage and is harmful to consumers...
  14. pmc Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway
    Estefania Moreno
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Biol Chem 286:5846-54. 2011
    ..artificial cell systems, we identified receptor heteromers between the dopamine D(1) or D(2) receptors and the histamine H(3) receptor...
  15. ncbi Evidence for activation of histamine H3 autoreceptors during handling stress in the prefrontal cortex of the rat
    Ben H C Westerink
    Department of Biomonitoring and Sensoring, University Center for Pharmacy, University of Groningen, Groningen 9713AV, The Netherlands
    Synapse 43:238-43. 2002
    On-line microdialysis of histamine in 10-min samples of the prefrontal cortex of the conscious rat is described...
  16. doi Histamine, histamine receptors and their role in immune pathology
    M Jutel
    Department of Clinical Immunology, Wroclaw University of Medicine, Wroclaw, Poland
    Clin Exp Allergy 39:1786-800. 2009
    The important roles of histamine in body physiology and various pathologic events have been well established, whereas new and exciting findings are still being uncovered...
  17. ncbi Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Germany
    J Neurophysiol 89:2441-8. 2003
    ..b>Histamine always provoked itching and rarely pain, capsaicin always pain but never itching...
  18. ncbi Cloning and functional expression of the human histamine H3 receptor
    T W Lovenberg
    R W Johnson Pharmaceutical Research Institute, San Diego, California, USA
    Mol Pharmacol 55:1101-7. 1999
    b>Histamine regulates neurotransmitter release in the central and peripheral nervous systems through H3 presynaptic receptors...
  19. pmc Rate, extent and concentration dependence of histamine-evoked Weibel-Palade body exocytosis determined from individual fusion events in human endothelial cells
    M Erent
    Medical Research Councils National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Physiol 583:195-212. 2007
    The rate, concentration dependence and extent of histamine-evoked Weibel-Palade body (WPB) exocytosis were investigated with time-resolved fluorescence microscopy in cultured human umbilical vein endothelial cells expressing WPB-targeted ..
  20. pmc Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells
    Anne McIlroy
    Immunology and Allergology Laboratory, University Hospital of Angers, University of Angers, Angers, France
    Immunology 117:507-16. 2006
    ..In mucosa, at the sites of allergen entry, immature dendritic cells (DC) are in close contact with mast cells. Histamine and prostaglandin E2 (PGE2) are two mediators released by allergen-activated mast cells that favour the ..
  21. pmc Cellular basis of itch sensation
    Yan Gang Sun
    Departments of Anesthesiology, Psychiatry, and Developmental Biology, Washington University School of Medicine Pain Center, St Louis, MO 63110, USA
    Science 325:1531-4. 2009
    ..scratching deficits in response to all of the itching (pruritogenic) stimuli tested, irrespective of their histamine dependence. In contrast, pain behaviors were unaffected...
  22. doi Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine
    Tommas J Ellender
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, OX1 3TH, Oxford, United Kingdom
    J Neurosci 31:15340-51. 2011
    ..In view of the fact that the striatum also expresses a high density of histamine receptors, we hypothesized that released histamine will affect striatal function...
  23. pmc Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation
    Ana Rita Pinheiro
    From the Laboratório de Farmacologia e Neurobiologia, Unidade Multidisciplinar de Investigação Biomédica UMIB, and
    J Biol Chem 288:27571-83. 2013
    ..It has been demonstrated that mast cell-derived histamine plays an important role in painful fibrotic diseases...
  24. doi Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages
    Kazuya Masuda
    Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int Immunol 23:637-45. 2011
    ..Here, we show that Ahr also negatively regulates production of the pro-inflammatory cytokine IL-6 by suppressing histamine production in macrophages stimulated by LPS...
  25. ncbi Histamine in the immune regulation of allergic inflammation
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos
    J Allergy Clin Immunol 112:15-22. 2003
    b>Histamine was the first mediator implicated in mechanisms of allergy, asthma, and anaphylactic shock because it has been discovered to mimic several features of these diseases...
  26. doi Histamine facilitates consolidation of fear extinction
    Juliana Sartori Bonini
    Centro de Memoria, Instituto do Cérebro, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Int J Neuropsychopharmacol 14:1209-17. 2011
    ..b>Histamine modulates memory and anxiety but its role on fear extinction has not yet been evaluated...
  27. pmc Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase Cdelta-dependent ERK activation pathway
    Feng Hao
    Department of Pathobiology, The University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37996, USA
    J Biol Chem 283:26928-36. 2008
    b>Histamine, a potent inflammatory mediator, has multiple effects on the pathogenesis of atherosclerosis...
  28. pmc Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch
    Kush N Patel
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e20559. 2011
    ..Our findings demonstrate that the function of Pirt extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways...
  29. ncbi Mapping of serotonin, dopamine, and histamine in relation to different clock neurons in the brain of Drosophila
    Yasutaka Hamasaka
    Department of Zoology, Stockholm University, SE 10691, Sweden
    J Comp Neurol 494:314-30. 2006
    ..green fluorescent protein (GFP) expression, combined with immunocytochemistry with antisera against serotonin, histamine, and tyrosine hydroxylase (for dopamine)...
  30. pmc Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch
    T Akiyama
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
    Pain 151:378-83. 2010
    ..by acute intradermal injections of a protease-activated receptor (PAR)-2 agonist and serotonin (5-HT), but not histamine. We additionally investigated if pruritogen-evoked activity of dorsal root ganglion (DRG) neurons is enhanced in ..
  31. ncbi Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats
    Esmaeal Tamaddonfard
    Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia 57153 1177, Iran
    Pharmacol Rep 63:423-32. 2011
    ..systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine, pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), ..
  32. pmc Facial injections of pruritogens and algogens excite partly overlapping populations of primary and second-order trigeminal neurons in mice
    T Akiyama
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
    J Neurophysiol 104:2442-50. 2010
    ..Calcium imaging of primary sensory trigeminal ganglion (TG) cells showed that 15.4% responded to histamine, 5.8% to the protease-activated receptor (PAR)-2 agonist, 13.4% to allyl isothiocyanate (AITC), and 36...
  33. pmc Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch
    Alexandru D P Papoiu
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 6:e17786. 2011
    b>Histamine is the prototypical pruritogen used in experimental itch induction. However, in most chronic pruritic diseases, itch is not predominantly mediated by histamine...
  34. pmc In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans
    C Ma
    Dept of Anesthesiology, Yale Univ School of Medicine, New Haven, CT 06510, USA
    J Neurophysiol 107:357-63. 2012
    Native cowhage spicules, and heat-inactivated spicules containing histamine or capsaicin, evoke similar sensations of itch and nociceptive sensations in humans...
  35. ncbi Identification of Bphs, an autoimmune disease locus, as histamine receptor H1
    Runlin Z Ma
    Laboratory Animal Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China 100101
    Science 297:620-3. 2002
    Bphs controls Bordetella pertussis toxin (PTX)-induced vasoactive amine sensitization elicited by histamine (VAASH) and has an established role in autoimmunity...
  36. ncbi A high affinity serotonin- and histamine-binding lipocalin from tick saliva
    S Sangamnatdej
    CEH Oxford, Mansfield Road, Oxford, OX1 3SR, UK
    Insect Mol Biol 11:79-86. 2002
    To overcome the inflammatory response in its host, the cattle-feeding, brown ear tick secretes histamine-binding proteins into the feeding site...
  37. pmc Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors
    Eva Breunig
    Department of Human Biology, Technische Universitat Munchen, Hochfeldweg 2, Freising Weihenstephan, Germany
    J Physiol 583:731-42. 2007
    b>Histamine is a major mast cell mediator of immunoneural signalling in the gut and mast cells play a role in the pathophysiology of functional and inflammatory bowel diseases...
  38. doi Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses
    Arunesh Saras
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstrasse 150, D 44780 Bochum, Germany
    J Biol Chem 283:10470-5. 2008
    b>Histamine is not only a crucial cytokine in the periphery but also an important neurotransmitter and neuromodulator in the brain...
  39. doi Effects of histamine and diamine oxidase activities on pregnancy: a critical review
    Laura Maintz
    Department of Dermatology and Allergology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Hum Reprod Update 14:485-95. 2008
    b>Histamine has been assumed to contribute to embryo-uterine interactions due to its vasoactive, differentiation and growth-promoting properties. However, its exact functions in pregnancy are unclear...
  40. ncbi A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain
    C Pillot
    Laboratoire de Physiologie, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, 75006 Paris, France
    Neuroscience 114:173-93. 2002
    The detailed distribution of histamine H(3) receptor mRNAs in rat brain was analyzed by in situ hybridization using a 33P-labelled riboprobe and was combined for the first time with the detailed autoradiographic distribution of the ..
  41. doi Involvement of nitric oxide synthase in the mechanism of histamine-induced inhibition of Leydig cell steroidogenesis via histamine receptor subtypes in Sprague-Dawley rats
    Carolina Mondillo
    Laboratory of Molecular Endocrinology and Signal Transduction, Institute of Biology and Experimental Medicine Consejo Nacional de Investigaciones Científicas y Técnicas CONICET, CP 1428, Buenos Aires, Argentina
    Biol Reprod 80:144-52. 2009
    ..the so far unexplored intracellular mechanisms underlying negative modulation of Leydig cell steroidogenesis by histamine (HA)...
  42. pmc L-Dopa activates histaminergic neurons
    Yevgenij Yanovsky
    Department of Neurophysiology, Heinrich Heine University, D 40001, Dusseldorf, Germany
    J Physiol 589:1349-66. 2011
    ..This is delayed by lower dosage at early stages, made possible by additional treatment with histamine antagonists...
  43. pmc Sequencing and transcriptional analysis of the Streptococcus thermophilus histamine biosynthesis gene cluster: factors that affect differential hdcA expression
    Marina Calles-Enríquez
    Instituto de Productos Lacteos de Asturias, CSIC, 33300 Villaviciosa, Asturias, Spain
    Appl Environ Microbiol 76:6231-8. 2010
    b>Histamine, a toxic compound that is formed by the decarboxylation of histidine through the action of microbial decarboxylases, can accumulate in fermented food products...
  44. pmc Histamine receptors and cancer pharmacology
    Vanina A Medina
    Laboratory of Radioisotopes, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Br J Pharmacol 161:755-67. 2010
    Considerable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells...
  45. pmc Histamine-immunoreactive local neurons in the antennal lobes of the hymenoptera
    Andrew M Dacks
    Department of Neuroscience, The University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 518:2917-33. 2010
    ..For instance, the antennal lobes (ALs) of bumblebees possess both gamma-aminobutyric acid (GABA)- and histamine-immunoreactive (HA-ir) LNs, and both are neurotransmitters associated with fast forms of inhibition...
  46. doi Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis
    Farhad Jadidi-Niaragh
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Box 6446, Tehran 14155, Iran
    Neuropharmacology 59:180-9. 2010
    ..Experimental autoimmune encephalomyelitis (EAE) is the preferential experimental rodent model for MS. Histamine [2-(4-imidazole) ethylamine] is a ubiquitous inflammatory mediator of diverse physiological processes including ..
  47. doi Histamine regulates autoreactive T cell activation and adhesiveness in inflamed brain microcirculation
    Marilena Lapilla
    Neurological Institute Foundation, IRCCS Carlo Besta, 20133 Milan, Italy
    J Leukoc Biol 89:259-67. 2011
    b>Histamine may contribute to the pathology of MS and its animal model EAE. We explored the effects of histamine and specific HR agonists on activation and migratory capacity of myelin-autoreactive T cells...
  48. doi The role of cortical and hypothalamic histamine-3 receptors in the modulation of central histamine neurotransmission: an in vivo electrophysiology and microdialysis study
    Gunnar Flik
    Department of Biomonitoring and Sensoring, Groningen Research Institute of Pharmacy GRIP, University of Groningen, Groningen, The Netherlands
    Eur J Neurosci 34:1747-55. 2011
    The current study aimed to investigate the effect of histamine-3 (H(3)) receptors, expressed in the tuberomammillary nucleus (TMN) of the hypothalamus and in the prefrontal cortex (PFC), on histamine neurotransmission in the rat brain...
  49. ncbi Childhood factors that predict asthma in young adulthood
    B G Toelle
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    Eur Respir J 23:66-70. 2004
    ..At baseline, information about symptoms, spirometry, histamine challenge and skin-prick tests were collected...
  50. ncbi Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients
    M H Platzer
    National University Hospital, Allergy Clinic, Laboratory of Medical Allergology, Copenhagen, Denmark
    Allergy 60:1152-6. 2005
    Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU)...
  51. pmc VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch
    Malin C Lagerström
    Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden
    Neuron 68:529-42. 2010
    ..This study establishes that VGLUT2 is a major player in TRPV1 thermal nociception and also serves to regulate a normal itch response...
  52. pmc TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch
    Sarah R Wilson
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA
    Nat Neurosci 14:595-602. 2011
    ..the Mas-related G protein-coupled receptor (Mrgpr) family that are activated by mast cell mediators and promote histamine-independent itch...
  53. ncbi Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses
    R Rizzuto
    Department of Biomedical Sciences and the National Research Council Center for the Study of Biomembranes, University of Padova, Via Colombo 3, 35121 Padova, Italy
    Science 280:1763-6. 1998
    ..These results emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca2+ signaling...
  54. pmc Mast cell-derived histamine mediates cystitis pain
    Charles N Rudick
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 3:e2096. 2008
    ..We hypothesized that mast cells mediate pelvic pain directly and examined pain behavior using a murine model that recapitulates key aspects of IC...
  55. ncbi Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline)
    Ritchie E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Neurosci 22:8850-9. 2002
    ..Agonists of three arousal-related systems impinging on the dorsal raphe (orexin/hypocretin, histamine and the noradrenaline systems) caused an inward current and increase in current noise in whole-cell patch-clamp ..
  56. pmc Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:12911-6. 2003
    ..In hybridoma-transplanted mice, mucosal mast cell numbers correlate with serum IgE levels. Therefore, survival effects of IgE could contribute to the pathogenesis of allergic disease...
  57. doi Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFalpha release from canine skin mast cells
    S Cerrato
    UNIVET, Universitat Autonoma de Barcelona, Barcelona, Spain
    Vet Immunol Immunopathol 133:9-15. 2010
    ..b>Histamine, prostaglandin D(2) (PGD(2)) and tumour necrosis factor-alpha (TNFalpha) release was measured in the presence ..
  58. pmc Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models
    Christelle Anaclet
    INSERM U628, Integrated Physiology of Brain Arousal Systems, IFR19, 69373 Lyon, France
    J Neurosci 29:14423-38. 2009
    To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in maintaining wakefulness (W), we characterized the behavioral and sleep-wake phenotypes of orexin (Ox) knock-out (-/-) mice and compared them with ..
  59. pmc Separate peripheral pathways for pruritus in man
    Barbara Namer
    Department of Physiology and Pathophysiology, University of Erlangen Nurnberg, Germany
    J Neurophysiol 100:2062-9. 2008
    Recent findings suggest that itch produced by intradermal insertion of cowhage spicules in human is histamine independent. Neuronal mechanisms underlying nonhistaminergic itch are poorly understood...
  60. ncbi Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: results of a randomized phase 3 trial
    Mats Brune
    Department of Hematology, University of Goteborg, Goteborg, Sweden
    Blood 108:88-96. 2006
    ..of this phase 3 study was to determine whether postconsolidation immunotherapy with interleukin-2 (IL-2) and histamine dihydrochloride (HDC) improved the leukemia-free survival (LFS) of adult patients with acute myeloid leukemia (..
  61. ncbi Small- and intermediate-conductance Ca2+-activated K+ channels directly control agonist-evoked nitric oxide synthesis in human vascular endothelial cells
    Jian zhong Sheng
    Department of Pharmacology and Therapeutics, University of Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Cell Physiol 293:C458-67. 2007
    ..ATP or histamine evoked reproducible elevations in NO synthesis and cytosolic Ca(2+), as judged by 4-amino-5-methylamino-2',7'-..
  62. doi Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens
    Anne Dudeck
    Institute for Immunology, University of Technology Dresden, Medical Faculty Carl Gustav Carus, 01307 Dresden, Germany
    Immunity 34:973-84. 2011
    ..intravital imaging and showed that these adjuvant effects of contact allergens are mediated by mast cells and histamine. Mast cell deficiency resulted in impaired emigration of skin DCs to the lymph node and contact hypersensitivity ..
  63. pmc Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus
    Qin Liu
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Cell 139:1353-65. 2009
    The cellular and molecular mechanisms mediating histamine-independent itch in primary sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side effect of this widely used antimalarial drug...
  64. ncbi Immune regulation by histamine
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 14:735-40. 2002
    b>Histamine is a potent bioamine with multiple activities in various pathological and physiological conditions...
  65. ncbi A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice
    Silvia Musio
    Immunology and Muscular Pathology Unit, National Neurological Institute C Besta, Milan, Italy
    J Immunol 176:17-26. 2006
    b>Histamine can modulate the cytokine network and influence Th1 and Th2 balance and Ab-isotype switching...
  66. pmc Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    J Clin Invest 117:3507-18. 2007
    b>Histamine receptor H1 (H1R) is a susceptibility gene in both experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune orchitis (EAO), 2 classical T cell-mediated models of organ-specific autoimmune disease...
  67. pmc Remission maintenance in acute myeloid leukemia: impact of functional histamine H2 receptors expressed by leukemic cells
    Johan Aurelius
    Department of Sahlgrenska Cancer Center, University of Gothenburg, Sweden
    Haematologica 97:1904-8. 2012
    Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial...
  68. pmc Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway
    Heather Francis
    Central Texas Veterans Health Care System, Scott and White and Texas A and M Health Science Center College of Medicine, Medical Research Bldg, 702 SW H K Dodgen Loop, Temple, TX, 76504, USA
    Am J Physiol Cell Physiol 295:C499-513. 2008
    ..Four histamine receptors exist (HRH1, HRH2, HRH3, and HRH4)...
  69. pmc Involvement of protein kinase Cdelta/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 (PARP-1) signaling pathway in histamine-induced up-regulation of histamine H1 receptor gene expression in HeLa cells
    Hiroyuki Mizuguchi
    Department of Molecular Pharmacology, University of Tokushima Graduate School, Tokushima 770 8505, Japan
    J Biol Chem 286:30542-51. 2011
    The histamine H(1) receptor (H1R) gene is up-regulated in patients with allergic rhinitis. However, the mechanism and reason underlying this up-regulation are still unknown...
  70. doi Histamine and H1-antihistamines: celebrating a century of progress
    F Estelle R Simons
    Department of Pediatrics and Child Health and the Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Allergy Clin Immunol 128:1139-1150.e4. 2011
    ..we celebrate a century of progress since the initial description of the physiologic and pathologic roles of histamine and 70 years of progress since the introduction of H(1)-antihistamines for clinical use...
  71. pmc Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion
    Catherine S Chew
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 3175, USA
    Am J Physiol Gastrointest Liver Physiol 295:G37-G44. 2008
    ..b>Histamine-induced elevation of parietal cell [cAMP]i increases Lasp-1 phosphorylation, which is correlated with activation ..
  72. doi Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors
    Herman D Lim
    Leiden Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Pharmacol Exp Ther 327:88-96. 2008
    Using the natural variation in histamine H(4) receptor protein sequence, we tried to identify amino acids involved in the binding of H(4) receptor agonists...
  73. doi High constitutive activity and a G-protein-independent high-affinity state of the human histamine H(4)-receptor
    Erich H Schneider
    Department of Pharmacology and Toxicology, University of Regensburg, Universitatsstrasse 31, D 93040 Regensburg, Germany
    Biochemistry 48:1424-38. 2009
    The human histamine H(4)-receptor (hH(4)R) is expressed in mast cells and eosinophils and mediates histamine (HA)-induced chemotaxis via G(i)-proteins...
  74. doi Synergistic effect of histamine and TNF-α on monocyte adhesion to vascular endothelial cells
    Chong Chen
    Department of Biomedical Engineering, Tulane University, Lindy Boggs Center, Suite 500, New Orleans, LA 70118, USA
    Inflammation 36:309-19. 2013
    The histamine level is high during allergic attacks, and patients with allergy may have chronic inflammatory conditions at which tumor necrosis factor (TNF)-α is extensively released by macrophages...
  75. ncbi Histamine-mediated signaling processes in human malignant mammary cells
    Vanina Medina
    Radioisotopes Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Cancer Biol Ther 5:1462-71. 2006
    b>Histamine is a biogenic amine responsible for multiple biological actions including regulation of physiological functions of mammary gland...
  76. ncbi Histamine network in atherosclerosis
    Akihide Tanimoto
    Department of Pathology and Cell Biology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Trends Cardiovasc Med 16:280-4. 2006
    b>Histamine is a low-molecular-weight amine, synthesized from l-histidine by histidine decarboxylase...
  77. pmc Pharmacological characterization of GSK1004723, a novel, long-acting antagonist at histamine H(1) and H(3) receptors
    R J Slack
    Respiratory Biology, Respiratory CEDD, GlaxoSmithKline, Stevenage, UK
    Br J Pharmacol 164:1627-41. 2011
    Preclinical pharmacological characterization of GSK1004723, a novel, dual histamine H(1) and H(3) receptor antagonist.
  78. ncbi Role of macrophage-derived histamine in atherosclerosis-- chronic participation in the inflammatory response --
    Yasuyuki Sasaguri
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health
    J Atheroscler Thromb 11:122-30. 2004
    ..contains endothelial cells, smooth muscle cells, monocytes/macrophages and T lymphocytes, which constitute a histamine-cytokine network that participates in chronic inflammatory responses...
  79. pmc Histamine elevates free intracellular calcium in mouse retinal dopaminergic cells via H1-receptors
    Renata Frazao
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, Texas, USA
    Invest Ophthalmol Vis Sci 52:3083-8. 2011
    Previously, retinopetal axons containing histamine and dopaminergic neurons expressing histamine H(1)-receptor had been localized in mouse retinas using anatomic techniques...
  80. doi Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia
    Anna Martner
    University of Gothenburg, Guldhedsgatan 10B, 413 46 Goteborg, Sweden
    Expert Rev Hematol 3:381-91. 2010
    ..b>Histamine dihydrochloride (HDC) in combination with the T-cell-derived cytokine IL-2 was recently approved within the EU ..
  81. ncbi Preventive effect of acupuncture on histamine-induced itch: a blinded, randomized, placebo-controlled, crossover trial
    Florian Pfab
    J Allergy Clin Immunol 116:1386-8. 2005
  82. doi Greatly increased numbers of histamine cells in human narcolepsy with cataplexy
    Joshi John
    Neurobiology Research, Veterans Administration Greater Los Angeles Healthcare System, Neuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA
    Ann Neurol 74:786-93. 2013
    To determine whether histamine cells are altered in human narcolepsy with cataplexy and in animal models of this disease.
  83. ncbi Two cDNAs coding for histamine-gated ion channels in D. melanogaster
    Gunter Gisselmann
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstrasse 150, D 44780 Bochum, Germany
    Nat Neurosci 5:11-2. 2002
    b>Histamine, a neurotransmitter and neuroregulatory compound in diverse species, serves as the neurotransmitter of photoreceptors in insects and other arthropods by directly activating a chloride channel...
  84. doi Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis
    Peter Vadas
    Division of Allergy and Clinical Immunology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Allergy Clin Immunol 131:144-9. 2013
    Platelet-activating factor (PAF) is an important mediator and correlates with anaphylaxis severity. How well PAF correlates with severity relative to histamine or tryptase is not known.
  85. ncbi Cerebral ischemia and brain histamine
    Naoto Adachi
    Department of Anesthesiology and Resuscitology, Ehime University School of Medicine, Shitsukawa, Touon shi, Ehime 791 0295, Japan
    Brain Res Brain Res Rev 50:275-86. 2005
    ..b>Histamine plays a role as a neurotransmitter in the mammalian brain, and histamine release from nerve endings is enhanced ..
  86. ncbi Selective histamine uptake rescues photo- and mechanoreceptor function of histidine decarboxylase-deficient Drosophila mutant
    J Melzig
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Universitat Wurzburg, D 97074 Wurzburg, Germany
    J Neurosci 18:7160-6. 1998
    In insects, histamine is found both in the peripheral nervous system (PNS) and in the CNS and is known to function as a fast neurotransmitter in photoreceptors that have been shown to express selectively the hdc gene...
  87. pmc Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties
    Philippe de Medina
    INSERM UMR 1037, Team Sterol Metabolism and Therapeutic Innovations in Oncology, Cancer Research Center of Toulouse, F 31052 Toulouse, France
    Nat Commun 4:1840. 2013
    ..in mammalian tissues and normal cells as an enzymatic product of the conjugation of 5,6α-epoxy-cholesterol and histamine. Dendrogenin A was not detected in cancer cell lines and was fivefold lower in human breast tumours compared ..
  88. doi Microinjection of histamine into the cerebellar vermis impairs emotional memory consolidation in mice
    A C L Gianlorenço
    Laboratory of Neuroscience, Physiotherapy Department, Center of Biological Sciences and Health, Federal University of Sao Carlos, Brazil
    Brain Res Bull 86:134-8. 2011
    The biogenic amine histamine is an important neurotransmitter in the central nervous system that has been implicated in learning and memory processes...
  89. doi Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level
    Ke Yong Wang
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Arterioscler Thromb Vasc Biol 31:800-7. 2011
    b>Histamine and histamine receptors are found in atherosclerotic lesions, and their signaling and subsequent proatherogenic or proinflammatory gene expression are involved in atherogenesis...
  90. ncbi High constitutive activity of native H3 receptors regulates histamine neurons in brain
    S Morisset
    Unité de Neurobiologie et Pharmacologie Moléculaire U 109 de l INSERM, Centre Paul Broca, Paris, France
    Nature 408:860-4. 2000
    ..Inverse agonists may therefore find therapeutic applications, even in the case of diseases involving non-mutated receptors expressed at normal levels...
  91. pmc Histamine reduces flash sensitivity of on ganglion cells in the primate retina
    Nikolay P Akimov
    Departments of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, USA
    Invest Ophthalmol Vis Sci 51:3825-34. 2010
    ..The contribution of these neurons to vision, was examined by applying histamine to a dark-adapted, superfused baboon eye cup preparation while making extracellular recordings from peripheral ..
  92. doi Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function
    Tao Luo
    Department of Cardiology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, 510515, Guangzhou, China
    Basic Res Cardiol 108:342. 2013
    ..b>Histamine is known to increase vascular permeability and induce apoptosis, and these effects are closely associated with ..
  93. doi The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines
    Robin L Thurmond
    Johnson and Johnson Pharmaceutical Research and Development, L L C San Diego, California 92121, USA
    Nat Rev Drug Discov 7:41-53. 2008
    b>Histamine has a key role in allergic inflammatory conditions...
  94. doi Pilosulin 5, a novel histamine-releasing peptide of the Australian ant, Myrmecia pilosula (Jack Jumper Ant)
    Hidetoshi Inagaki
    Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Arch Biochem Biophys 477:411-6. 2008
    ..Synthetic pilosulin 5 peptide caused a significant histamine release in a dose-dependent manner, and the mastoparan homologous region of pilosulin 5 was responsible for the ..
  95. ncbi Histamine-induced chloride secretion is mediated via H2-receptors in the pig proximal colon
    F Ahrens
    Institute for Animal Welfare, Ethology and Animal Hygiene, Ludwig Maximilians University, Munich, Schwere Reiter Strasse 9, D 80797 Munich, Germany
    Inflamm Res 52:79-85. 2003
    The aim of this study was to investigate the action of histamine on function of epithelia in the pig proximal colon.
  96. pmc Cross-sensitization of histamine-independent itch in mouse primary sensory neurons
    T Akiyama
    University of California, Davis, Department of Neurobiology, Physiology and Behavior, 1 Shields Avenue, Davis, CA 95616, USA
    Neuroscience 226:305-12. 2012
    Overexpression of pruritogens and their precursors may contribute to the sensitization of histamine-dependent and -independent itch-signaling pathways in chronic itch...
  97. pmc Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model
    M Gschwandtner
    Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria
    Allergy 68:37-47. 2013
    ..Mast cells and their main mediator histamine are abundant in inflamed skin and thus may contribute to disease pathogenesis.
  98. ncbi The human histamine H2-receptor couples more efficiently to Sf9 insect cell Gs-proteins than to insect cell Gq-proteins: limitations of Sf9 cells for the analysis of receptor/Gq-protein coupling
    Christine Houston
    Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, USA
    J Neurochem 80:678-96. 2002
    The human histamine H2-receptor (hH2R) couples to Gs-proteins to activate adenylyl cyclase and to Gq-proteins to activate phospholipase C, but phospholipase C activation has not consistently been observed...
  99. doi Cough reflex sensitivity and airway inflammation in patients with chronic cough due to non-acid gastro-oesophageal reflux
    Zhihong Qiu
    Departments of Respiratory Medicine Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
    Respirology 16:645-52. 2011
    ..The aim of this study was to explore the pathogenesis of chronic cough caused by non-acid reflux...
  100. ncbi Brain activation by histamine prick test-induced itch
    B Walter
    J Invest Dermatol 125:380-2. 2005
  101. ncbi IL-3-induced coexpression of histidine decarboxylase, IL-4 and IL-6 mRNA by murine basophil precursors
    E Schneider
    CNRS URA 1461, Universite Rene Descartes Paris V, Hopital Necker, France
    Exp Hematol 27:1010-8. 1999
    ..from the blast cell window on the basis of high rhodamine-123 retention (Rh-bright), are highly enriched in histamine-, IL-4-, and IL-6-producing cells...

Research Grants71

  1. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..When these receptors are crosslinked by polyvalent allergens, the cells release inflammatory mediators such as histamine and leukotrienes...
  2. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Histamine is a potent mediator of inflammation and regulator of innate and adaptive immune responses, and autoimmune diseases such as experimental allergic encephalomyelitis (EAE), the principal ..
  3. Histamine modulation of biliary proliferation and damage
    Heather L Francis; Fiscal Year: 2013
    ..of biliary histidine decarboxylase (HDC, the enzyme, also expressed by cholangiocytes in the liver, regulating histamine synthesis), histamine synthesis and histamine receptor interaction on cholangiocyte proliferation and/or damage...
  4. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..Unlike first generation antipsychotics (FGAs), SGAs bind multiple receptors including dopamine, serotonin, histamine and alpha-adrenergic receptors and could therefore affect multiple tissues and organ systems...
  5. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..Mice will be evaluated for the magnitude of allergic response via IgE, histamine, IL-4, and IL-13 levels, airway resistance, inflammatory pulmonary infiltrates, and airway remodeling...
  6. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..Prominent examples include serotonin, histamine, adrenergic, muscarinic and calcitonin receptors which are targets of current and potentially new drugs...
  7. Pharmacology of Risperidone Effects on Bone Remodeling and Energy Metabolism
    Karen L Houseknecht; Fiscal Year: 2013
    ..antagonize multiple G protein coupled receptors (GPCRs) including dopamine, serotonin, alpha- adrenergic and histamine receptors...
  8. Organic Cation Transporter PMAT: Physiological Function and Role in Drug Disposit
    Joanne Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Many drugs (e.g. biguanide antihyperglycemics, histamine H2 receptor blockers, platinum-based chemotherapeutics etc.) and toxins (e.g...
  9. THE FUNCTION AND REGULATION OF HISTIDINE DECARBOXYLASE IN GUT INFLAMMATION
    TIMOTHY CRAGIN WANG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The enzyme histidine decarboxylase (HDC) converts L-histidine to histamine, a biogenic amine that functions in numerous physiologic processes, but has increasingly been linked to immune regulation...
  10. Preoptic histamine signaling in thermoregulation and energy expenditure
    IUSTIN VIRGIL TABAREAN; Fiscal Year: 2012
    b>Histamine signaling in the hypothalamus controls energy expenditure, thermoregulation, sleep and feeding. Transgenic animals in which histamine signaling is disrupted (the H1 receptor k.o., the H3 receptor k.o...
  11. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    ..While many forms of itch are mediated by histamine signaling, recent work by us and others makes clear that additional key neural pathways are at play...
  12. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..afferents at their synapses with individually identified ENS neurons and the transmitters that evoke release of histamine and mast cell proteases form intramural mast cells in response to electrical or chemical activation of the ..
  13. Mechanism and functional role of AKAP79/150 in M current control
    Mark S Shapiro; Fiscal Year: 2012
    ..variety of Gq/11-linked receptor types that are critical to pain and inflammation, including bradykinin, PAR-2, histamine, angiotensin II and purinergic receptors...
  14. Tie2 Activation for the Treatment of Chemical-Induced Acute Lung Injury
    Christopher D Kontos; Fiscal Year: 2013
    ..k.a., vascular permeability factor), serotonin, and histamine, suggesting that this pathway non-specifically inhibits vascular permeability...
  15. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    FRANCES ANN WALKER; Fiscal Year: 2012
    ..The NPs are novel ferriheme proteins that are reversible carriers of nitric oxide (NO) and tight binders of histamine. They are the only known heme proteins with the heme inside a ?-barrel (lipocalin fold)...
  16. Mechanisms of Cardiac Afferents and CNS Reflex Processing
    John C Longhurst; Fiscal Year: 2013
    ..These include bradykinin (BK), reactive oxygen species, protons, cyclooxygenase metabolites, serotonin (5HT), histamine, and most recently thromboxane A2 and endothelin...
  17. Histamine Receptor Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2013
    ..provided by applicant): Our preliminary studies have identified two original cardioprotective effects of histamine H3-receptor activation...
  18. The Role of IgE in Autoimmune Skin Diseases
    Janet A Fairley; Fiscal Year: 2013
    ..These IgE autoantibodies predominantly target the same region of the BP antigen as IgG (NC16A), trigger histamine release from basophils and produce lesions that mimic the early stage of lesion development in BP in a xenograft ..
  19. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..We will examine effects of alfentanil on ex vivo dural MC degranulation and histamine release and granuloma formation after 28 days of infusion. Hypothesis 4...
  20. Gut L-Histidine Metabolism and Histamine Signaling in Colonic Neoplasia
    James Versalovic; Fiscal Year: 2013
    ..recent findings, intestinal bacteria can convert amino acids, such as L-histidine, into biogenic amines, such as histamine, that suppress pro-inflammatory cytokine production by impeding MAP kinase signaling...
  21. Mast cell dependent inflammatory cascade during influenza A virus infection
    Joshua J Obar; Fiscal Year: 2013
    ..Furthermore, others have reported that during IAV infection of humans significantly elevated levels of histamine can be detected coincident with IAV induced symptoms...
  22. Effect of Atypical Antipsychotics on Fructose Metabolism and Weight Gain
    CAROLINE PALAVICINO-MAGGIO; Fiscal Year: 2012
    ..on the following observations- (1) The target receptors for antipsychotics including dopamine, serotonin and histamine receptors are expressed in the intestine;(2) our preliminary result that chronic clozapine treatment increases ..
  23. G-Protein Coupled Receptor Kinase-2 on IgE Signaling in Mast Cells
    Hydar Ali; Fiscal Year: 2012
    ..Thus, aggregation of high affinity IgE receptor (Fc5RI) by allergen on mast cells results in rapid histamine release and the generation of lipids and cytokines, which are responsible for the manifestations of allergic ..
  24. A Tissue Implantable Microbiosensor
    Peter A Petillo; Fiscal Year: 2012
    ..neurologically relevant analytes, including, but not limited to, glucose, glutamate, lactate, choline, histamine, D-serine, and ethanol...
  25. Synaptic Mechanisms of Hypothalamic Control of Vigilance and Cognitive Function
    ALEXANDER CHOI JACKSON; Fiscal Year: 2013
    ..One such circuit in the brain, which releases the neurotransmitter histamine, is thought to have an important role in mediating wakefulness and enhancing higher brain function but, until ..
  26. Interplay between LTE4/LTE4 receptors and IFN-y with mast cells and eosinophils i
    Larry C Borish; Fiscal Year: 2013
    ..These cells preserve relevant features of mast cells including possessing secretory granules containing histamine and surface expression of Fc5RI1...
  27. 7th World Congress on Itch (WCI)
    Ethan A Lerner; Fiscal Year: 2013
    ..measures, that distinct but overlapping populations of sensory neurons mediate itch from different stimuli, that histamine-independent itch drives most itches, the identification transient receptor potential (TRP) channels and mas-..
  28. Bronchodilator Effects of Toll-Like Receptor-7 Agonists.
    David B Jacoby; Fiscal Year: 2011
    ..airways, namely that they are potent bronchodilators, and prevent bronchoconstriction caused by methacholine, histamine, stimulation of parasympathetic nerves, and depolarization of smooth muscle by potassium chloride...
  29. Exercise, histamine receptors, and vascular function
    Steven A Romero; Fiscal Year: 2012
    ..provided by applicant): The long-term goal of this project is explore the relationship between exercise and histamine receptor activation in order to improve overall health and cardiovascular wellness...
  30. MAINTENANCE AND OPERATION OF A SYNTHETIC PEPTIDE FACILITY
    JEANICK PASCAL; Fiscal Year: 2010
    ..of substititon at CllB-4-aryl and C17&a;2) steroid haptens linked to bovine serum a1bumin as well as to histamine conjugates for the development of radioimmunoassay (RIA...
  31. MAINTENANCE AND OPERATION OF A SYNTHETIC PEPTIDE FACILITY
    JEANICK PASCAL; Fiscal Year: 2009
    ..of substititon at CllB-4-aryl and C17&a;2) steroid haptens linked to bovine serum a1bumin as well as to histamine conjugates for the development of radioimmunoassay (RIA...
  32. Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its Resolution
    Darlene A Dartt; Fiscal Year: 2012
    ..The chronic stimulation could arise from mediators of conjunctival inflammation, such as leukotrienes and histamine, stimulating goblet cell secretion...
  33. Oxidized lipids and UV immunosuppression
    Jeffrey B Travers; Fiscal Year: 2013
    ..of cell types and cytokines including mast cells, cyclooxygenase-2-produced eicosanoids, interleukin-10 and histamine. Two specific aims are planned to mechanistically characterize the complex pathway of UVB-mediated systemic ..
  34. Orphan nuclear receptor Nur77 and intestinal inflammmation
    Dezheng Zhao; Fiscal Year: 2010
    ..tumor necrosis factor-1 (TNF1), vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) and histamine are two potent microvascular permeability factors that are involved in dysfunction of microvascular endothelium...
  35. Functional Analysis of Mrgpr Family in Itch Sensation
    Xinzhong Dong; Fiscal Year: 2013
    ..provided by applicant): The goal of our research is to understand the cellular and molecular mechanisms of histamine-independent itch...
  36. Plasma Serum Based Biomarkers in Sublingual Oral Immunotherapy for Milk Allergy
    John T Schroeder; Fiscal Year: 2013
    ..specimens from CMA subjects will be tested in flow-based assays for their ability to induce basophil spontaneous histamine release (SHR), the expression of markers (CD63/CD203c) linked to IgE-dependent activation as well as those (syk ..
  37. Neural Mechanisms of Itch
    Earl E Carstens; Fiscal Year: 2013
    ..of the itch mediators serotonin, agonists of protease-activated receptor (PAR) subtypes 2 and 4, and histamine, elicit scratching behavior in mice in a manner that is consistent with itch sensation in humans...
  38. Assembly Line Biosynthesis of Bacterial Siderophores
    FRED L HEFFRON; Fiscal Year: 2012
    ..acid (DHBA) and cyclization to generate dihydroxyphenylthiazolyn (DHPT);the transfer of DHPT to N-hydroxy- histamine by the C domain of AngM. 2...
  39. Characterization of the Role of Histamine in Children with Asthma
    Bridgette L Jones; Fiscal Year: 2013
    ..have shown that there may be a beneficial effect of antihistamines in patients with allergic asthma where histamine likely plays a large role in disease and treatment response...
  40. Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Wayne G Shreffler; Fiscal Year: 2009
    ..IgE is bound by receptors on immune cells, such as basophils, and can lead to the release of histamine and other substances when it comes into contact with peanut allergen...
  41. Fetal Ethanol Effects on Histaminergic Regulation of Neurotransmission
    DANIEL DEXTER SAVAGE; Fiscal Year: 2013
    ..We have observed that the histamine H3 receptor antagonist ABT-239 ameliorates fetal ethanol-induced deficits in dentate gyrus long-term ..
  42. Sphingosine-1-Phosphate, A Novel Mediator of Human Skin Mass Cell Functions
    Carole A Oskeritzian; Fiscal Year: 2010
    ..of the high affinity receptor for IgE (FcepsilonRI) on mast cells causes their degranulation, release of histamine and other preformed mediators, as well as several proinflammatory cytokines and chemokines...
  43. Mechanism and pathophysiological significance of mast cell regulated exocytosis
    Roberto Adachi; Fiscal Year: 2013
    ..It is accepted that mast cell degranulation should be important in the early allergic response because histamine and serotonin are secreted through this mechanism...
  44. Mast Cell S1P Receptor2 in the initiation and progression of chronic inflammation
    Carole A Oskeritzian; Fiscal Year: 2013
    ..in inflammation by releasing pre-formed as well as de novo synthesized various inflammatory mediators, including histamine, cytokines, and chemokines upon allergen cross-linking of high affinity receptors for IgE (Fc?RI)...
  45. Sphingolipid Signaling in Endothelial Function
    Menq Jer Lee; Fiscal Year: 2012
    ..Moreover, the S1P1-transduced signaling inhibits the histamine-induced vessel leakage in the Sprague Dawley (SD) rat...
  46. Basophils in Modulating Th2 Responses in Human Allergic Disease
    John T Schroeder; Fiscal Year: 2011
    ..In humans, these rare granulocytes release inflammatory mediators (histamine and LTC4) and cytokines (IL-4 and IL-13) central in the pathogenesis of allergic disease...
  47. Structural Studies of Vesicular Monoamine Transporters
    SATINDER KAUR SINGH; Fiscal Year: 2013
    ..Substrates include serotonin, dopamine, norepinephrine, epinephrine, and histamine. The significance of VMAT2 is underscored by the phenomenal levels (~500 mM) to which it concentrates its ..
  48. Mechanisms of Allergic Transfusion Reactions
    William Savage; Fiscal Year: 2013
    ..Products of basophil activation such as histamine and cysteinyl leukotrienes will be measured...
  49. Molecular basis of atypical antipsychotic drugs-induced weight gain
    Sangwon F Kim; Fiscal Year: 2013
    ..This activation occurs secondary to the drugs'blocking the histamine H1 receptor for histamine, which, besides its roles in allergy, is a neurotransmitter in the feeding centers of ..
  50. Interaction Between the Epithelium and Mast Cells in Severe Asthma
    MERRITT LYNN FAJT; Fiscal Year: 2012
    ..2) Determine the presence and relative concentration of activation markers for mast cells including tryptase, histamine, and prostaglandin D2 in lavage fluid and sputum...
  51. Regulation of Effector CD4 T Cells During Infection
    Ralph C Budd; Fiscal Year: 2010
    ..Project 1 (Dr. Cory Teuscher) studies newly discovered roles for histamine and the four histamine receptors expressed by CD4 T cells during the transition from naive to effector to memory ..
  52. Itch, proteases and protease-activated receptors
    Ethan A Lerner; Fiscal Year: 2013
    ..Although most experimental studies of itch use histamine as the pruritic stimulus, most cases of clinical pruritus are considered to be histamine independent...
  53. IgE to carbohydrates causes delayed anaphylaxis
    SCOTT PALMER COMMINS; Fiscal Year: 2013
    ..Using histamine release and basophil activation studies, we will determine whether IgE to alpha-gal can be functionally ..
  54. Measurement of physiological secretory vesicle-plasma membrane tethering forces o
    Manfred Lindau; Fiscal Year: 2011
    ..This mechanism mediates release of neurotransmitters, hormones as well as many other compounds including histamine from mast cells or cytotoxic proteins from eosinophilic granulocytes...
  55. Exercise, Histamine Receptors, &Vascular Health In Aging
    John R Halliwill; Fiscal Year: 2013
    ..The long- term goal of this proposal is to understand the link between exercise, histamine receptors, and alterations in endothelial and vascular function so that we can exploit this link to generate ..
  56. Histamine and Neutrophil Influx in the Pathogenesis of Acute Lung Injury
    CRAIG ALEXANDER SMUDA; Fiscal Year: 2013
    ..Our preliminary studies have suggested that receptors for the biogenic amine histamine, produced by mast cells in peripheral tissues, is important to recruitment immune cells to the lung...
  57. Targeting sphingosine kinases in FceRI-mediated allergic responses
    Sarah Spiegel; Fiscal Year: 2012
    ..perpetuate allergic responses through their ability to release a wide array of inflammatory mediators, including histamine and other preformed mediators, de novo synthesized arachidonic acid metabolites (leukotrienes and prostaglandins)..
  58. Visual system synapses and circuits
    Ian A Meinertzhagen; Fiscal Year: 2013
    ..phenotype of photoreceptors, or the targeting of their terminals, as well as the recycling of neurotransmitter, histamine, through a beta-alanyl conjugation pathway...
  59. Neural Mechanisms of Itch
    ROBERT H LA MOTTE; Fiscal Year: 2013
    ..of nociceptive primary neurons and nociceptive spinothalamic tract (STT) neurons, some responsive to histamine, and others to the spicules of cowhage that evoked a histamine independent itch via a novel cysteine protease ..
  60. Quetiapine Pharmacotherapy for Cannabis Dependence
    John J Mariani; Fiscal Year: 2013
    ..Quetiapine, an effective atypical antipsychotic that acts by blocking serotonin type 2A, dopamine type 2, histamine type 1, and adrenergic receptors, is a promising treatment for substance use disorders...
  61. Histamine Receptor Signaling in CNS Autoimmune Disease
    Cory Teuscher; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Histamine, a mediator of inflammation and regulator of innate and adaptive immune responses, plays a significant role in the pathogenesis of experimental allergic encephalomyelitis (EAE), the ..
  62. MOLECULAR IMAGING OF BIOMATERIALS - SINGLE CELLS
    Nicholas Winograd; Fiscal Year: 2012
    ..of phospholipid membrane layers and the temporal behavior of small molecules such as dopamine, seratonin, and histamine involved in the process of exocytosis...
  63. Betahistine: Novel Therapeutic in Attention Deficit Hyperactivity Disorder
    CHARLES PIERCE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Satiety Solutions, is developing a novel histamine agonist, betahistine, as a treatment for attention-deficit, hyperactivity disorder (ADHD)...
  64. MAST CELL MEMBRANE GLYCOLIPID EXPRESSION AND FUNCTION
    Michael Raizman; Fiscal Year: 1991
    ..of interleukin 3- dependent, mouse bone marrow culture-derived mast cells induces an increase in both the histamine content and the DNA synthesis of these cells...
  65. PATHOGENESIS OF ALLERGIC DISEASES OF THE SKIN & LUNGS
    Allen Kaplan; Fiscal Year: 1992
    ..We will study molecular mechanisms of histamine release from basophils and mast cells, activation of the classical complement pathway, and activation of the ..
  66. Identification Of Proteins Responsible For Peanut Allergenicity
    Fred Finkelman; Fiscal Year: 2009
    ..cells but is accompanied by mast cell activation;3) platelet activating factor (PAF) and, to a lesser extent, histamine contribute to PE-induced shock;4) TLR2, TLR4, MyD88, and the adaptive immune system are not required for PE-..
  67. NON-GASTRIN SECRETAGOGUE PEPTIDE IN ISLET CELL TUMORS
    William Chey; Fiscal Year: 1999
    ..bioactivity of the extract potentiated mutually with gastrin to stimulate gastric acid secretion and stimulated histamine release from isolated rat enterochromaffin-like (ECL) cells that was independent of gastrin/CCK-B receptor...
  68. PROSTAGLANDINS AND LOCAL CONTROL OF THE CIRCULATION
    ALAN NIES; Fiscal Year: 1990
    ..The gastric studies will examine the factors controlling histamine release from the gastric mucosa since both the prostaglandins and H2-histamine blockers specifically act by ..
  69. GAMMA GLOBULIN STRUCTURE AND HYPERSENSITIVITY
    Kimishige Ishizaka; Fiscal Year: 1992
    ..study whether guanidine- nucleotide binding protein(s) is involved in the IgE-mediated activation of PLC and histamine release...
  70. GASTRIC H+ ION TRANSPORT--CELLULAR CONTROL MECHANISMS
    CATHERINE CHEW; Fiscal Year: 1999
    ..A better understanding of the mechanisms by which the major acid secretory agonists, histamine, acetylcholine and gastrin, and other factors control parietal cell acid secretion will allow for development of ..
  71. HISTAMINE CONTAINING CENTRIFUGAL AXONS IN THE RETINA
    David Marshak; Fiscal Year: 2000
    ..The long-term goal of the proposed research is to understand the role of histamine released from centrifugal axons in the etiology of small vessel damage to the retina of diabetic patients...