deoxyepinephrine

Summary

Summary: Sympathomimetic, vasoconstrictor agent.

Top Publications

  1. ncbi Effect of ibopamine on aqueous humor production in normotensive humans
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 44:4853-8. 2003
  2. ncbi The comparison of topical ibopamine 2% with tonography to identify the outflow resistance in eyes with ocular hypertension
    Ibrahim F Hepsen
    Department of Ophthalmology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey
    Ophthalmic Res 37:17-22. 2005
  3. pmc Validated liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxym
    Melanie Mueller
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D 66421 Homburg Saar, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 855:262-70. 2007
  4. ncbi Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity
    Helena Carmo
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Pharmacogenet Genomics 16:789-99. 2006
  5. ncbi Correlation between the ibopamine provocative test and the diurnal tension curve in glaucoma patients
    Leopoldo Magacho
    Setor de Glaucoma, Centro de Referência em Oftalmologia, Universidade Federal de Goias, Goiania, GO, Brasil
    Arq Bras Oftalmol 69:477-80. 2006
  6. ncbi Neurotoxicity mechanisms of thioether ecstasy metabolites
    J P Capela
    REQUIMTE Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    Neuroscience 146:1743-57. 2007
  7. ncbi Ibopamine provocative test and glaucoma: consideration of factors that may influence the examination
    Leopoldo Magacho
    Ophthalmology Department CEROF, Federal University of Goias, Goiania, Brazil
    Curr Eye Res 28:189-93. 2004
  8. ncbi Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates
    Márcia Carvalho
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4050 047 Porto, Portugal
    Arch Toxicol 78:16-24. 2004
  9. ncbi Ibopamine test and frequency doubling perimetry in early glaucoma diagnosis
    M Virno
    Institute of Ophthalmology, La Sapienza, University Rome
    Acta Ophthalmol Scand Suppl 236:31. 2002
  10. ncbi Comparative study of the effects of 2% ibopamine, 10% phenylephrine, and 1% tropicamide on the anterior segment
    Giorgio Marchini
    University Eye Clinic, Department of Neurological and Visual Sciences, University of Verona, Ospedale di Borgo Trento, I 37126 Verona, Italy
    Invest Ophthalmol Vis Sci 44:281-9. 2003

Research Grants

  1. SAFETY ASSESSMENT OF FENFLURAMINE/PHENTERMINE
    George Ricaurte; Fiscal Year: 2001
  2. GENE EXPRESSION AND METHAMPHETAMINE NEUROTOXICITY
    George Ricaurte; Fiscal Year: 2002
  3. MDMA Neurotoxicity in Nonhuman Primates
    George Ricaurte; Fiscal Year: 2005
  4. MDMA Neurotoxicity in Humans: Occurence & Consequences
    George Ricaurte; Fiscal Year: 2006
  5. Methamphetamine Neurotoxicity in Nonhuman Primates
    George Ricaurte; Fiscal Year: 2006
  6. ADHD Treatment & Amphetamine Neurotoxicity
    George Ricaurte; Fiscal Year: 2007
  7. Metabolism and Pharmacogenetics in MDMA-Induced Toxicity
    Rafael de la Torre; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. ncbi Effect of ibopamine on aqueous humor production in normotensive humans
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 44:4853-8. 2003
    Ibopamine is a prodrug of epinine (deoxyepinephrine) that exhibits activity at dopaminergic and adrenergic receptors...
  2. ncbi The comparison of topical ibopamine 2% with tonography to identify the outflow resistance in eyes with ocular hypertension
    Ibrahim F Hepsen
    Department of Ophthalmology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey
    Ophthalmic Res 37:17-22. 2005
    ..To evaluate the ability of topical ibopamine 2% to detect outflow resistance by comparing it with the tonography test in eyes with ocular hypertension (OHT)...
  3. pmc Validated liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxym
    Melanie Mueller
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D 66421 Homburg Saar, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 855:262-70. 2007
    ..The present method should prove useful for acquiring pharmacokinetic and toxicokinetic data in squirrel monkeys...
  4. ncbi Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity
    Helena Carmo
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Pharmacogenet Genomics 16:789-99. 2006
    ..Therefore, we tested whether CYP2D6 or its variant alleles as well as CYP3A4 influence the susceptibility to 3,4-methylenedioxymethamphetamine...
  5. ncbi Correlation between the ibopamine provocative test and the diurnal tension curve in glaucoma patients
    Leopoldo Magacho
    Setor de Glaucoma, Centro de Referência em Oftalmologia, Universidade Federal de Goias, Goiania, GO, Brasil
    Arq Bras Oftalmol 69:477-80. 2006
    ..To correlate the ibopamine provocative test with the diurnal tension curve (highest intraocular pressure-IOP and range) in glaucoma...
  6. ncbi Neurotoxicity mechanisms of thioether ecstasy metabolites
    J P Capela
    REQUIMTE Rede de Química e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    Neuroscience 146:1743-57. 2007
    ..This study provides new insights into the neurotoxicity mechanisms of thioether MDMA metabolites and highlights their importance in "ecstasy" neurotoxicity...
  7. ncbi Ibopamine provocative test and glaucoma: consideration of factors that may influence the examination
    Leopoldo Magacho
    Ophthalmology Department CEROF, Federal University of Goias, Goiania, Brazil
    Curr Eye Res 28:189-93. 2004
    ..To evaluate factors that may influence the ibopamine provocative test for the diagnosis of glaucoma...
  8. ncbi Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates
    Márcia Carvalho
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4050 047 Porto, Portugal
    Arch Toxicol 78:16-24. 2004
    ..The results provide evidence that one of the early consequences of MDMA metabolism is a disruption of thiol homeostasis, which may result in loss of protein function and the initiation of a cascade of events leading to cellular damage...
  9. ncbi Ibopamine test and frequency doubling perimetry in early glaucoma diagnosis
    M Virno
    Institute of Ophthalmology, La Sapienza, University Rome
    Acta Ophthalmol Scand Suppl 236:31. 2002
  10. ncbi Comparative study of the effects of 2% ibopamine, 10% phenylephrine, and 1% tropicamide on the anterior segment
    Giorgio Marchini
    University Eye Clinic, Department of Neurological and Visual Sciences, University of Verona, Ospedale di Borgo Trento, I 37126 Verona, Italy
    Invest Ophthalmol Vis Sci 44:281-9. 2003
    ..To assess in normal and glaucomatous eyes the effect of the dopaminergic drug 2% ibopamine on visual acuity, IOP, pupil size and anterior segment geometry, compared with 10% phenylephrine and 1% tropicamide...
  11. ncbi [Prostaglandin analogues reduce the ibopamine provocative test specificity in glaucoma]
    Leopoldo Magacho
    Centro de Referência em Oftalmologia, Universidade Federal de Goias, Goiania, GO, Brazil
    Arq Bras Oftalmol 69:193-6. 2006
    ..To evaluate the ibopamine provocative test for the diagnosis of glaucoma in glaucoma patients using antiglaucomatous drugs...
  12. ncbi Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro
    Márcia Carvalho
    REQUIMTE, Serviço de Toxicologia, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    Chem Res Toxicol 17:623-32. 2004
    ....
  13. ncbi Epinephrine synthesis by rat arteries
    B Kennedy
    Department of Medicine, University of California San Diego Medical Center 92103
    Am J Hypertens 4:45-50. 1991
    ..This enzyme differs from adrenal PNMT in substrate and inhibitor specificity and its activity is enhanced by catecholamine depletion and by glucocorticoid treatment...
  14. ncbi Interactions of epinephrine, norepinephrine, dopamine and their corresponding alpha-methyl-substituted derivatives with alpha and beta adrenoceptors in the pithed rat
    R R Ruffolo
    J Pharmacol Exp Ther 230:595-600. 1984
    ..Furthermore, the results show that alpha-methylepinephrine is a potent beta adrenoceptor agonist, with an apparent 500-fold selectivity for beta-2 adrenoceptors over beta-1 adrenoceptors...
  15. pmc A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice
    Isabel Escobedo
    Departamento Farmacologia, Facultad Medicina, Universidad Complutense, 28040 Madrid, Spain
    Br J Pharmacol 144:231-41. 2005
    ..6. The fact that the acute changes induced by i.p. or intrastriatal HHMA administration differed indicates that HHMA is metabolised to other compounds which are responsible for changes observed after i.p. administration...
  16. ncbi Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy
    O E Brodde
    Department of Internal Medicine, University of Essen, Germany
    J Cardiovasc Pharmacol 31:585-94. 1998
    ..The extent of reduction was not different for each agonist in ICM and DCM. We conclude that in DCM and ICM, functional responsiveness of all cardiac Gs-coupled receptors is similarly reduced...
  17. ncbi Epinephrine induced platelet aggregation in rat platelet-rich plasma
    H S Yun-Choi
    Natural Products Research Institute, Seoul National University, 110 460, Seoul, Republic of Korea
    Thromb Res 100:511-8. 2000
    ..These results suggested that the epinephrine-induced rat platelet aggregation is occurring through alpha2-adrenergic receptors as is the case with human platelets...
  18. ncbi High-performance liquid chromatography with electrochemical detection applied to the analysis of 3,4-dihydroxymethamphetamine in human plasma and urine
    M Segura
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    J Chromatogr B Analyt Technol Biomed Life Sci 769:313-21. 2002
    ..Intermediate precision and inter-day accuracy were within 3.9-6.5% and 7.4-15.3% for urine and 5.0-10.8% and 9.2-13.4% for plasma...
  19. ncbi Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its major metabolites in squirrel monkeys at plasma concentrations of MDMA that develop after typical psychoactive doses
    Melanie Mueller
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 327:38-44. 2008
    ..By raising MDMA concentrations and prolonging its action, nonlinear pharmacokinetics and T(1/2) prolongation, respectively, may influence the likelihood and severity of MDMA toxicities (including brain serotonin neurotoxicity)...
  20. ncbi Dopaminergic control of aldosterone secretion is not mediated by atrial natriuretic factor in patients with essential hypertension
    C Sala
    Istituto di Clinica Medica Generale, Universita di Milano, Italy
    J Hypertens Suppl 6:S336-8. 1988
    ..Thus, it appears that the suppressive effect exerted by the dopaminergic tone on aldosterone secretion is independent of ANF both before and after dopaminergic stimulation...
  21. ncbi The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6)
    G T Tucker
    Department of Medicine and Pharmacology, University of Sheffield, Royal Hallamshire Hospital, U K
    Biochem Pharmacol 47:1151-6. 1994
    ..Thus, MDMA is converted to the catecholamine DHMA by CYP2D6, and this may give rise to genetically-determined differences in toxicity...
  22. ncbi [Endothelium-protective effects of epinine (N-methyldopamine) in myocardial ischemia-reperfusion in the isolated working rat heart]
    P Di Napoli
    Istituto di Clinica Cardiovascolare, Universita degli Studi G D Annunzio, Chieti
    Cardiologia 42:1173-8. 1997
    ..The importance of dopaminergic receptors is also suggested by the evidence that at higher doses, when alpha and beta-adrenoceptors stimulation occurs, this cardioprotective effect is significantly reduced or lost...
  23. ncbi The effects of ibopamine on glomerular filtration rate and plasma norepinephrine remain preserved during prolonged treatment in patients with congestive heart failure
    A G Lieverse
    Department of Internal Medicine, University Hospital Groningen, Netherlands
    Eur Heart J 16:937-42. 1995
    ..Subsequently the patients continued to take ibopamine 100 mg three times daily for one month, at which time the chronic effects were measured on the third study day...
  24. ncbi Cardiovascular and renal action of dopaminergic prodrugs
    C Casagrande
    Simes Cardiovascular Research Centre, Zambon Group, Cormano, Milan, Italy
    J Cardiovasc Pharmacol 14:S40-59. 1989
    ..e., epinine-4-O-phosphate. The latter is shown to act as a selective renal vasodilator on oral administration in dogs and it is therefore proposed for clinical investigation in renal failure and in essential hypertension...
  25. ncbi High activity of semicarbazide-sensitive amine oxidase (SSAO): an important source of errors in the determination of the concentration of dopamine in pig plasma
    F Boomsma
    Department of Internal Medicine I, Erasmus University University Hospital Dijkzigt, Rotterdam, The Netherlands
    J Cardiovasc Pharmacol 22:198-202. 1993
    ..The possibility of similarly high plasma SSAO activity in other species should be investigated further...
  26. ncbi Pharmacotherapeutic profile of ibopamine in heart failure
    S H Taylor
    Department of Cardiovascular Studies, University of Leeds, U K
    J Cardiovasc Pharmacol 14:S118-23. 1989
    ..The unique pharmacotherapeutic profile of ibopamine affords a new pharmacologic vista for the treatment of patients with chronic heart failure...
  27. ncbi Progression of mild untreated heart failure during six months follow-up and clinical and neurohumoral effects of ibopamine and digoxin as monotherapy. DIMT Study Group. Dutch Ibopamine Multicenter Trial
    D J van Veldhuisen
    Department of Cardiology Thoraxcenter, University Hospital Groningen, The Netherlands
    Am J Cardiol 75:796-800. 1995
    ..Plasma renin and aldosterone levels were unchanged after 6 months in the placebo group, but digoxin therapy slightly reduced plasma renin concentration (-5 microU/ml; p < 0.05 vs placebo).(ABSTRACT TRUNCATED AT 250 WORDS)..
  28. pmc Early cardiovascular changes with ibopamine: evidence for a biphasic haemodynamic action
    K J Hogg
    Department of Materia Medica, University of Glasgow, Stobhill General Hospital
    Br J Clin Pharmacol 24:435-42. 1987
    ..4. These results support a biphasic mode of action for ibopamine which may be explained by a time phase difference in alpha- and beta-adrenoceptor stimulatory effects...
  29. ncbi Can drug effects on mortality in heart failure be predicted by any surrogate measure?
    K M Yee
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK
    Eur Heart J 18:1860-4. 1997
    ..The most promising surrogates are heart rate variability, QT dispersion and plasma neurohormones, the first two for sudden death and the last one for death from progressive disease...
  30. ncbi Ibopamine. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy
    J M Henwood
    ADIS Drug Information Services, Manchester, England
    Drugs 36:11-31. 1988
    ..Should the results of long term comparative studies confirm these encouraging findings, ibopamine will be a useful addition to the drugs available or as an alternative to digoxin for the treatment of congestive heart failure...
  31. ncbi Effect of beta-alkyl substitution on D-1 dopamine agonist activity: absolute configuration of beta-methyldopamine
    R M Riggs
    Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907
    J Med Chem 30:1914-8. 1987
    ..The absolute configuration of beta-methyldopamine was determined to be R-(+) and S-(-). Evaluation of (R)-(+)- and (S)-(-)-beta-methyldopamine revealed no enantioselectivity for stimulation of adenylate cyclase...
  32. ncbi New inotropic concepts: rationale for and differences between calcium sensitizers and phosphodiesterase inhibitors
    C Holubarsch
    Department of Cardiology and Angiology, University of Freiburg, Germany
    Cardiology 88:12-20. 1997
    ....
  33. ncbi The effects of oral ibopamine in patients with mild heart failure--a double blind placebo controlled comparison to furosemide. The Ibopamine Study Group
    J O Parker
    Cardiovascular Laboratory, Kingston General Hospital, Ontario, Canada
    Int J Cardiol 40:221-7. 1993
    ..The results of this study show the usefulness of both ibopamine and furosemide as monotherapy in patients with mild congestive heart failure...
  34. pmc Comparison of captopril and ibopamine in mild to moderate heart failure
    H J Dohmen
    Department of Cardiology, Bosch Medicentrum, s Hertogenbosch, The Netherlands
    Heart 78:285-90. 1997
    ..To determine the effects of ibopamine 100 mg three times daily compared with captopril 25 mg three times daily on exercise capacity in patients with chronic heart failure...
  35. ncbi Pharmacokinetics and pharmacodynamics of single oral doses of ibopamine, quinidine and their combination in normal man
    C de Mey
    SK and F Institute for Applied Clinical Pharmacology, Gottingen, Federal Republic of Germany
    Eur J Clin Pharmacol 34:415-8. 1988
    ..min-1) and mean QTc (+30 ms). These changes were sustained up to 8 h after dosing, and were not affected by concurrent ibopamine...
  36. ncbi Systemic and coronary hemodynamic actions of the novel inotropic agent, ibopamine, and the de-esterified metabolite and active form, epinine: relationship to left ventricular performance in the dog
    G A Kopia
    Department of Pharmacology, Smith Kline and French Laboratories, Swedeland, Pennsylvania
    J Pharmacol Exp Ther 246:434-40. 1988
    ..However, neither drug increased myocardial work, myocardial oxygen consumption or contractility to a greater extent than the increase in coronary blood flow.(ABSTRACT TRUNCATED AT 250 WORDS)..
  37. pmc Pharmacological evidence for the presence of a peripheral postjunctional D2-like dopamine receptor in rabbit splenic artery
    D Zanzottera
    Zambon Group S p A, R and D Division, Bresso Milan, Italy
    Br J Pharmacol 123:730-6. 1998
    ....
  38. ncbi Increase in aqueous humor production following D1 receptors activation by means of ibopamine
    M Virno
    Department of Ocular Physio Pharmacology, Eye Clinic, University La Sapienza, Rome, Italy
    Int Ophthalmol 20:141-6. 1996
    ..In normal eyes, ibopamine has no effect on IOP...
  39. ncbi Confounding by contraindication in a nationwide cohort study of risk for death in patients taking ibopamine
    H Feenstra
    Department of Internal Medicine, Albert Schweitzer Hospital, Box 444, 3300 AK Dordrecht, The Netherlands
    Ann Intern Med 134:569-72. 2001
    ..Outcomes may differ in treated and untreated patients because of a contraindication for treatment in the latter that is independently associated with the outcome of interest...
  40. ncbi Dynamic evaluation by TV-pupillometry of the mydriatic effect of ibopamine solution. Controlled studies
    G Micieli
    Department of Neurology, C Mondino Foundation, University of Pavia, Italy
    Arzneimittelforschung 40:150-6. 1990
    ..The effect of ibopamine 1% on the pupillary reflex to near vision is slight, while on the reflex to light stimulus it is essentially comparable to that of tropicamide...
  41. ncbi [Ibopamine--clinical results]
    F X Kleber
    Abteilung für Kardiologie und Pneumologie, Krankenhaus München Schwabing
    Z Kardiol 80:71-6. 1991
    ..Historically, controls of patients with heart failure of similar severity do not suggest any unfavorable effect of this drug on prognosis...
  42. ncbi [Positive ibopamine provocative test in normal-tension glaucoma suspects]
    C Kniestedt
    Augenklinik, Kantonspital Winterthur, Winterthur, Schweiz
    Klin Monbl Augenheilkd 224:255-9. 2007
    ..Ibopamine is an alpha-adrenergic agent and causes an elevation of intraocular pressure in eyes with increased outflow resistance. It has been proposed as a test substance for the detection of early ocular hydrodynamic disorders...
  43. ncbi Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants
    Irene Antolino-Lobo
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
    Toxicology 289:175-84. 2011
    ..However, SFN supplementation should be considered with care because of the indications of possible drug-drug interactions...
  44. ncbi 3-O-methyldopamine (3-O-methoxytyramine) interferes with the internal standard 3,4-dihydroxybenzylamine in a plasma catecholamine HPLC method
    Albrecht Pfäfflin
    Clin Chem 53:1976-7. 2007
  45. ncbi Simultaneous determination of free catecholamines and epinine and estimation of total epinine and dopamine in plasma and urine by high-performance liquid chromatography with fluorimetric detection
    F Boomsma
    Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam, Netherlands
    J Chromatogr 574:109-17. 1992
    ..This method, in which deconjugation is accomplished by acid hydrolysis at 95 degrees C, also shows good sensitivity and reproducibility...
  46. ncbi [2% ibopamine vs. water-drinking test as a provocative test for glaucoma]
    Leopoldo Magacho
    Setor de Glaucoma, CEROF, Universidade Federal de Goiânia, Goiania GO, Brasil
    Arq Bras Oftalmol 71:499-503. 2008
    ..To compare the 2% ibopamine provocative test with the water drinking test as a provocative test for glaucoma...
  47. ncbi Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes
    Vera Marisa Costa
    REQUIMTE Rede de Qumica e Tecnologia, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Chem Res Toxicol 22:129-135. 2009
    ..In the present experimental conditions, P-gp activity is absent in the isolated cardiomyocytes...
  48. ncbi [Effects of 2% ibopamine eye drops on the results of computerized visual field]
    Mara Agi Pigini
    Universidade Federal de Goias, Goiania, GO, Brasil
    Arq Bras Oftalmol 72:365-9. 2009
    ..To evaluate the influence of 2% ibopamine eye drops on the results of computerized visual field exams...
  49. pmc Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity
    Melanie Mueller
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 21224, USA
    Synapse 65:983-90. 2011
    ..A large (greater than 70%) decrease in HHMA formation had no effect on the magnitude of MDMA neurotoxicity. These results cast doubt on the role of HHMA-derived catechol-thioether metabolites in the mechanism of MDMA neurotoxicity...
  50. ncbi The oral dopamine agonist, ibopamine, in normal man: effects on rhythm, heart rate, blood pressure and catecholamines
    D J van Veldhuisen
    Department of Cardiology Thoraxcenter, University Hospital Groningen, The Netherlands
    Int J Clin Pharmacol Res 11:159-65. 1991
    ..In conclusion, in healthy subjects ibopamine appears to be a safe drug and causes neither proarrhythmia, nor changes in heart rate, blood pressure, ECG-parameters, or plasma catecholamines...
  51. ncbi Treatment of mild chronic congestive heart failure with ibopamine, hydrochlorothiazide, ibopamine plus hydrochlorothiazide or placebo. A double-blind comparative study
    F X Kleber
    Academic Teaching Hospital, Munich, FRG
    Cardiology 77:67-74. 1990
    ..All active treatments were well tolerated. There was a trend towards a higher incidence of hypokalemia in patients treated with HCTZ, alone or in combination, compared to those receiving ibopamine alone or placebo...
  52. ncbi Lung epinephrine synthesis
    B Kennedy
    Department of Medicine, University of California Medical Center, San Diego 92103
    Am J Physiol 258:L227-31. 1990
    ..We used the rate of E formation from NE as an index of PNMT-like activity and deoxyepinephrine synthesis from DA as an index of NMT-like activity...
  53. ncbi Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites in human samples including the catechol-type metabolite (3,4-dihydroxymethamphetamine)
    Nieves Pizarro
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Universitat Autonoma de Barcelona, Spain
    Drug Metab Dispos 32:1001-7. 2004
    ..8 h) correlates with mood and cognitive effects experienced on the next days after MDMA use...
  54. ncbi Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct
    M Hiramatsu
    Department of Pharmacology, University of California, Los Angeles School of Medicine
    J Pharmacol Exp Ther 254:521-7. 1990
    ..The formation of this quinone and its thiol adducts may account for some of the irreversible actions of this compound on serotonergic neurons...
  55. ncbi Endogenous synthesis of N-methylnorsalsolinol in rat brain during in vivo microdialysis with epinine
    M Kajita
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    J Chromatogr B Biomed Appl 654:263-9. 1994
    ..We demonstrated that NMNSAL could be synthesized from epinine with an aldehyde by the Piclet-Spengler condensation reaction in the rat brain...
  56. ncbi Comparison between the 1% and 2% ibopamine provocative test in primary open-angle glaucoma patients: sensitivity, specificity and tolerability
    Leopoldo Magacho
    Sector de Glaucoma do Centro de Referência em Oftalmologia da Universidade Federal de Goiânia GO, Brasil
    Arq Bras Oftalmol 69:695-9. 2006
    ..To compare intraocular pressure (IOP) rise in normal individuals and primary open-angle glaucoma patients and the safety and efficacy of ibopamine eye drops in different concentrations as a provocative test for glaucoma...
  57. ncbi A comparison of the inotropic effects of dopamine and epinine in human isolated cardiac preparations
    G Bravo
    Laboratoire de Pharmacologie, Universite Catholique de Louvain, Bruxelles, Belgium
    J Pharmacol Exp Ther 257:439-43. 1991
    ..The results indicate that, compared to dopamine in isolated human heart preparations, epinine was more potent at beta-2 relative to beta-1 adrenoceptors...
  58. ncbi Ibopamine versus digoxin in the treatment of mild congestive heart failure. A double-blind, randomized, placebo-controlled trial
    F X Kleber
    Academic Teaching Hospital, Munich, FRG
    Cardiology 77:75-80. 1990
    ..We conclude that ibopamine monotherapy over 4 weeks has favourable effects on body weight and signs and symptoms of mild congestive heart failure without exerting major side effects. The efficacy is comparable to digoxin therapy...
  59. pmc Failure of "effective" treatment for heart failure to improve normal customary activity
    J T Walsh
    University Hospital, Nottingham
    Br Heart J 74:373-6. 1995
    ..To examine the effects of drug treatment on laboratory exercise tests in relation to measures of daily activity in patients with chronic heart failure...
  60. ncbi The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine
    Márcia Carvalho
    REQUIMTE, Serviço de Toxicologia, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha 164, 4099 030, Portugal
    Toxicology 200:193-203. 2004
    ..Oxidative stress may play a major role in N-Me-alpha-MeDA-induced hepatic toxicity since antioxidant defense systems are impaired and administration of antioxidants prevented N-Me-alpha-MeDA toxicity...
  61. ncbi Relation between myocardial beta-adrenoceptor density and hemodynamic and neurohumoral changes in a rat model of chronic myocardial infarction: effects of ibopamine and captopril
    D J van Veldhuisen
    Department of Cardiology Thorax Center, University Hospital Groningen, Netherlands
    Cardiovasc Res 30:386-93. 1995
    ..In addition, we examined the effects of 8 weeks treatment with ibopamine and captopril...
  62. ncbi Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column
    Y Deng
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Chromatogr B Biomed Appl 670:47-54. 1995
    ..Preliminary results indicate that the (R)-enantiomer of both isoquinoline derivatives predominate in the human brain...
  63. ncbi [Treatment of uveitis-associated refractory ocular hypotony with topical ibopamine]
    B K Windisch
    Universitats Augenklinik, Inselspital Bern, Schweiz
    Klin Monbl Augenheilkd 223:422-4. 2006
    ..This novel drug can be used as a mydriatic agent, as a provocative test in open-angle glaucoma, and for the treatment of persisting ocular hypotony...
  64. ncbi Comparative effects of long-term therapy with captopril and ibopamine in chronic congestive heart failure in old patients
    A Barabino
    Department of Internal Medicine, University of Genova, Italy
    Cardiology 78:243-56. 1991
    ..The study provides evidence of the clinical usefulness of both captopril or ibopamine in the long-term treatment of CHF in old patients. The safety profile of each drug will suggest the preferred therapeutic application...
  65. ncbi Endothelium dependent relaxation in two different models of chronic heart failure and the effect of ibopamine
    H Buikema
    Department of Pharmacology Clinical Pharmacology, University of Groningen, The Netherlands
    Cardiovasc Res 27:2118-24. 1993
    ..The purpose was to relate endothelium dependent relaxation to neurohumoral and haemodynamic changes in rats with chronic heart failure...
  66. ncbi Low-dosage ibopamine treatment in progressive renal failure: a long-term multicentre trial
    S Stefoni
    Chair of Nephrology, University of Bologna, Italy
    Am J Nephrol 16:489-99. 1996
    ..The trial suggests that low-dosage ibopamine administration may be used as a valid and safe pharmacological adjunct for retarding the progression of renal failure in patients with mild or moderate chronic renal impairment...
  67. pmc A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system
    Fouad El-Shehabi
    Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada
    PLoS Negl Trop Dis 6:e1523. 2012
    ..This investigation has identified potentially important differences between SmGPR-3 and host dopamine receptors that could be exploited to develop new, parasite-selective anti-schistosomal drugs...
  68. ncbi Ibopamine: long-term safety study in patients with congestive heart failure. The Italian Ibopamine Working Group
    E Riva
    Smith Kline and French, Clinical Research and Development, Milan, Italy
    Int J Clin Pharmacol Res 9:21-8. 1989
    ..This trial suggests that ibopamine is well tolerated in patients with congestive heart failure, NYHA class II and III, at the dose of 100 mg thrice daily for up to one year...
  69. ncbi Ethnic differences in the renal sodium dopamine relationship. A possible explanation for regional variations in the prevalence of hypertension?
    M R Lee
    University Department of Clinical Pharmacology, Royal Infirmary, Edinburgh, Scotland
    Am J Hypertens 3:100S-103S. 1990
    ....
  70. ncbi Effects of ibopamine on renal haemodynamics in patients with severe congestive heart failure
    A R Girbes
    Department of Surgery, University Hospital Groningen, Netherlands
    Eur Heart J 14:279-83. 1993
    ..Ibopamine caused no clinically significant natriuresis in these salt-depleted patients. No changes in PRA, aldosterone and catecholamines were found...
  71. ncbi Positive inotropism and myocardial energetics: influence of beta receptor agonist stimulation, phosphodiesterase inhibition, and ouabain
    C Holubarsch
    Department of Physiology and Biophysics, University of Vermont, Burlington
    Cardiovasc Res 28:994-1002. 1994
    ..The aim was to study the effect of three positive inotropic interventions on myocardial force development and heat production in guinea pig papillary muscles in order to investigate the energetic consequences...
  72. ncbi Electrophysiologic profile of ibopamine in patients with congestive heart failure and ventricular tachycardia and relation to its effects on hemodynamics and plasma catecholamines
    D J van Veldhuisen
    Department of Cardiology, University Hospital Groningen, The Netherlands
    Am J Cardiol 68:1194-202. 1991
    ..Plasma norepinephrine decreased significantly after ibopamine (p = 0.02) but plasma epinephrine was unaffected.(ABSTRACT TRUNCATED AT 250 WORDS)..
  73. ncbi Hemodynamic and neurohumoral effects of ibopamine in patients with chronic congestive heart failure
    J Lopez-Sendon
    Servicio de Coronariopatias, Hospital La Paz, Madrid, Spain
    Cardiology 77:9-21. 1990
    ....
  74. ncbi Efficacy of ibopamine treatment in patients with advanced heart failure: purpose of a new therapeutic scheme with multiple daily administrations
    L Dei Cas
    Cattedra di Cardiologia, Universita degli Studi di Brescia, Italy
    J Cardiovasc Pharmacol 14:S111-7. 1989
    ..8 +/- 32.4 pmol/ml; after acute and repeated administration of ibopamine, free epinine plasma concentrations averaged 45.1 +/- 14.5 and 62.2 +/- 12.7 pmol/ml, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)..
  75. ncbi Major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons
    U D McCann
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, D C
    Brain Res 545:279-82. 1991
    ..These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved...
  76. ncbi Effect of ibopamine on the failing heart at rest and during isometric exercise: a noninvasive study
    J Partanen
    First Department of Medicine, University Central Hospital, Helsinki, Finland
    Clin Cardiol 11:15-22. 1988
    ..Neither urine volume nor body weight changed. Side effects were mild except for tachycardia of one patient.(ABSTRACT TRUNCATED AT 250 WORDS)..
  77. ncbi Effect of methyl derivatives of dopamine on tumor necrosis factor alpha and lipid peroxidation
    Mary C Perianayagam
    Division of Nephrology, Department of Medicine, Caritas St Elizabeth s Medical Center, 736 Cambridge St, Boston, MA 01235, USA
    Ann N Y Acad Sci 1122:253-9. 2007
    ..Our results indicated that the inhibitory effect of NAS, NAD, NMD, or 4-O-MD on LPS-induced TNF-alpha production and FeCl(2)-stimulated lipid peroxidation is robust and dose dependent...
  78. ncbi Comparative effects of ibopamine and captopril in mild congestive heart failure. Focus on the long-term effects of inodilation on ventricular arrhythmias
    M Cocchieri
    Divisione di Cardiologia di Perugia, Italia
    Cardiology 77:36-42. 1990
    ..Our results show that ibopamine exerts no significant effects on either heart rate or ventricular arrhythmias and that indexes of left ventricular function are not modified by any treatment in mild congestive heart failure...
  79. ncbi Long-term therapy of chronic congestive heart failure with ibopamine: a multicenter trial
    E Rolandi
    ISMI, Universita degli Studi di Genova, Italy
    J Cardiovasc Pharmacol 14:S93-103. 1989
    ..No tolerance to ibopamine seems to be observed during this long-term therapeutic trial...
  80. ncbi Chiral CE separation of dopamine-derived neurotoxins
    Zhe Quan
    Department of Chemistry, Jackson State University, 1400 Lynch St, Jackson, MS 39217, USA
    Anal Sci 21:115-9. 2005
    ..The later is known to induce Parkinsonism in rats...
  81. ncbi The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure
    D J van Veldhuisen
    Department of Cardiology Thoraxcentre, University Hospital Groningen, P O Box 30001, 9700 RB, Groningen, The Netherlands
    Int J Cardiol 80:19-27. 2001
    ..In this article we will discuss some of these trials that were conducted in the last 10 years, since we believe they may provide insight into the pathophysiology and treatment options in CHF...
  82. ncbi Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis
    Nieves Pizarro
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    J Anal Toxicol 26:157-65. 2002
    ..Stereoselective disposition of MDMA and MDA was confirmed. HMMA disposition seems to be in apparent contradiction with MDMA findings as the enantiomer ratio is close to 1 and constant over the time...
  83. ncbi [Comparison between kinetics of positive inotropism of ibopamine and ouabain]
    J Huang
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing, China
    Zhongguo Yao Li Xue Bao 17:66-8. 1996
    ..To compare the kinetics of positive inotropism between ibopamine (Ibo) and ouabain (Oua)...
  84. ncbi Clinical efficacy of ibopamine in patients with chronic heart failure
    M Metra
    Cattedra di Cardiologia, Universita di Brescia, Italy
    Clin Cardiol 18:I22-31. 1995
    ..It is also possible that ibopamine will improve survival in these patients. Large-scale trials are needed to assess the effects on morbidity and mortality when ibopamine is added to ACE inhibitors, diuretics, and possibly digitalis...
  85. ncbi [Metabolites of ecstasy and cytotoxicity effects]
    M B Fleury
    UMR 8638, Faculte des Sciences Pharmaceutiques et Biologiques, CNRS Universite Paris Descartes, 4, avenue de l Observatoire, 75270 Paris Cedex 06, France
    Ann Pharm Fr 67:91-6. 2009
    ..The second one is an assay of cellular viability, performed on rat hippocampal pyramidal neurons. It confirms that some of these metabolites exhibit a noticeable cytotoxicity by markedly eliciting both necrosis and apoptosis markers...
  86. pmc Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes
    Daniel José Barbosa
    REQUIMTE Rede de Química e Tecnologia, Laboratorio de Toxicologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Br J Pharmacol 165:1017-33. 2012
    ....
  87. ncbi Effects of ibopamine on exercise-induced increase in norepinephrine in normal men
    A R Girbes
    Department of Surgery, University Hospital Groningen, The Netherlands
    J Cardiovasc Pharmacol 19:371-4. 1992
    ..In conclusion, ibopamine blunts the increase of plasma NE during graded exercise in healthy men...
  88. ncbi Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma
    Luana Cahya Ugahary
    The Rotterdam Eye Hospital, PO Box 70030, 3000 LM Rotterdam, The Netherlands
    Am J Ophthalmol 141:571-3. 2006
    ..To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma...
  89. ncbi Effects of acute and chronic ibopamine administration on resting and exercise hemodynamics, plasma catecholamines and functional capacity of patients with chronic congestive heart failure
    L Dei Cas
    Cattedra di Cardiologia, Universita di Brescia, Italy
    Am J Cardiol 70:629-34. 1992
    ..Thus, the hemodynamic and neurohumoral effects of ibopamine make this drug potentially useful for the chronic treatment of congestive heart failure...
  90. pmc Development and validation of LC-HRMS and GC-NICI-MS methods for stereoselective determination of MDMA and its phase I and II metabolites in human urine
    Andrea E Schwaninger
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D 66421 Homburg Saar, Germany
    J Mass Spectrom 46:603-14. 2011
    ....
  91. ncbi Effects of ibopamine eye drops on intraocular pressure and aqueous humor flow in healthy volunteers and patients with open-angle glaucoma
    H Azevedo
    AIBILI, Clinical Trial Centre, Azinhaga St Comba, Celas, Coimbra, Portugal
    Eur J Ophthalmol 13:370-6. 2003
    ..On the basis of intraocular pressure measurements and fluorophotometry we assessed the effects of 2% ibopamine eye drops on aqueous humor production in normal and glaucomatous eyes...
  92. ncbi The effects of 2% ibopamine eye drops on the intraocular pressure and pupil motility of patients with open-angle glaucoma
    I Giuffre
    Neurosciences Department, La Sapienza University, Roma Italy
    Eur J Ophthalmol 14:508-13. 2004
    ....
  93. ncbi Renal and humoral effects of ibopamine, a dopamine agonist, in patients with liver cirrhosis
    F Salerno
    Institute of Internal Medicine, University of Milan Medical School, Italy
    Arch Intern Med 150:65-9. 1990
    ..However, these properties of dopaminergic agents are apparently lost in patients with avid sodium retention...
  94. ncbi Development of dopaminergic drugs for the chronic treatment of congestive heart failure
    C Casagrande
    Simes Cardiovascular Research Centre, Cormano, Milan, Italy
    J Auton Pharmacol 10:s85-93. 1990
    ....
  95. ncbi The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver
    M Strolin Benedetti
    Department of Preclinical Development and Human Pharmacology, Zambon Group, Bresso, Italy
    J Neural Transm Suppl 52:233-8. 1998
    ..The results of this study show that epinine is a substrate for both forms of MAO in rat liver, although the contribution of MAO A to the deamination of this secondary amine appears to be slightly more important than that of MAO B...
  96. ncbi Stereostructure activity relationships of catecholamines on human platelet function
    C H Ahn
    Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus 43210
    Proc Soc Exp Biol Med 194:149-56. 1990
    ....
  97. ncbi How to select a drug for the long-term treatment of chronic heart failure
    A J Man in 't Veld
    Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University Rotterdam, The Netherlands
    Am Heart J 120:1572-8. 1990
    ..None of the currently available drugs satisfies all these criteria. Diuretics, digitalis, converting-enzyme inhibitors, and ibopamine come close to the described ideal...
  98. ncbi Safety of ibopamine therapy in congestive heart failure. Ibopamine cohort study: baseline and 1-year results
    D Sher
    Zambon Group Scientific Department, Bresso Milan, Italy
    Arzneimittelforschung 41:402-9. 1991
    ....
  99. ncbi [Changes in the cardio-thoracic index during the treatment with ibopamine]
    L Piccini
    Istituto di Clinica Medica Generale e Terapia Medica III, Universita degli Studi di Firenze
    Clin Ter 138:83-6. 1991
    ..561 +/- 0.058 to an average of 0.538 +/- 0.052, (p less than 0.01). This finding, together with the disappearance of dyspnea and edema, confirms that there was a change in disease pattern and that treatment with this drug was effective...
  100. pmc Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity
    Melanie Mueller
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
    Drug Metab Dispos 37:2079-86. 2009
    ....
  101. ncbi Hemodynamic effects of ibopamine on the pulmonary circulation and right ventricular performance in patients with chronic obstructive pulmonary disease
    K Skwarski
    Department of Medicine, City Hospital, Edinburgh, UK
    Cardiology 80:349-55. 1992
    ....

Research Grants7

  1. SAFETY ASSESSMENT OF FENFLURAMINE/PHENTERMINE
    George Ricaurte; Fiscal Year: 2001
    ....
  2. GENE EXPRESSION AND METHAMPHETAMINE NEUROTOXICITY
    George Ricaurte; Fiscal Year: 2002
    ..abstract_text> ..
  3. MDMA Neurotoxicity in Nonhuman Primates
    George Ricaurte; Fiscal Year: 2005
    ..abstract_text> ..
  4. MDMA Neurotoxicity in Humans: Occurence & Consequences
    George Ricaurte; Fiscal Year: 2006
    ....
  5. Methamphetamine Neurotoxicity in Nonhuman Primates
    George Ricaurte; Fiscal Year: 2006
    ....
  6. ADHD Treatment & Amphetamine Neurotoxicity
    George Ricaurte; Fiscal Year: 2007
    ....
  7. Metabolism and Pharmacogenetics in MDMA-Induced Toxicity
    Rafael de la Torre; Fiscal Year: 2009
    ..A study will compare MDMA toxicity when co-adminsitered with the MRP1 inhibitor probenecid. ..