Genomes and Genes
Summary: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
Publications278 found, 100 shown here
- CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injuryT Schallert
Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
Neuropharmacology 39:777-87. 2000..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
- Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity researchYuen Ting Cheung
Laboratory of Neurodegenerative Diseases, Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Neurotoxicology 30:127-35. 2009..As a result, the real toxicity cannot be revealed in RA-differentiated cells. Therefore, undifferentiated SH-SY5Y is more appropriate for studying neurotoxicity or neuroprotection in experimental Parkinson's disease research...
- Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathwayRonald Deumens
Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, 6200 MD Maastricht, The Netherlands
Exp Neurol 175:303-17. 2002..The choice of the behavioral parameters determines the use of unilateral or bilateral lesions, although it is obvious that the bilateral model mimics the human situation more closely...
- Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's diseaseRuben K Dagda
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Autophagy 4:770-82. 2008..These data indicate that mitochondrial localization of ERK2 activity is sufficient to recapitulate the effects of 6-OHDA on mitophagy and autophagic cell death...
- Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's diseaseElizabeth J Ryu
Department of Pathology, Center for Neurobiology and Behavior, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Neurosci 22:10690-8. 2002..Our findings, coupled with evidence from familial forms of Parkinson's disease, raise the possibility of widespread involvement of endoplasmic reticulum stress and the unfolded protein response in the pathophysiology of this disease...
- Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTPAndreas Schober
Department of Neuroanatomy and IZN, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
Cell Tissue Res 318:215-24. 2004..The new genetic and environmental toxin models of PD (e.show $132#g. rotenone, paraquat, maneb) are discussed elsewhere in this "special issue."..
- Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neuronsWilliam Andrew Holtz
Anatomy and Neurobiology Department, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 278:19367-77. 2003..The involvement of UPR in these widely used neurotoxin models supports the role of ubiquitin-proteasome pathway dysfunction in PD...
- Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studiesFernanda Martins Lopes
Department of Biochemistry, ICBS UFRGS, Porto Alegre RS, Brazil
Brain Res 1337:85-94. 2010..Our data suggest that SH-SY5Y cells differentiated by 7 days with the protocol described here represent a more suitable experimental model for studying the molecular and cellular mechanisms underlying the pathophysiology of PD...
- Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus networkP J Magill
Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
Neuroscience 106:313-30. 2001..Furthermore, the relative contribution of rate and pattern to aberrant information coding is intimately related to the state of activation of the cerebral cortex...
- Therapeutic benefit of TH-engineered mesenchymal stem cells for Parkinson's diseaseLingling Lu
Beijing Institute for Neuroscience, The Beijing Center of Neural Regeneration and Repairing, Capital University of Medical Sciences, 10 You anMen Wai Xitoutiao, Beijing 100054, P R China
Brain Res Brain Res Protoc 15:46-51. 2005..05). All the data demonstrated that MSCs could readily be genetically engineered. Therefore, MSCs could be useful gene delivery vehicles of gene therapy for Parkinson's disease...
- 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase CdeltaKatharine Hanrott
Department of Biology and Biochemistry, University of Bath, 4 South, Claverton Down, Bath BA2 7AY, United Kingdom
J Biol Chem 281:5373-82. 2006....
- Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's diseaseM Lundblad
Department of Physiological Sciences, Wallenberg Neuroscience Centre, Neurobiology Division, Lund University, BMC A11, S 221 84 Lund, Sweden
Eur J Neurosci 15:120-32. 2002..Such deficits can be quantified using novel and relatively simple testing procedures, whereas rotometry cannot discriminate between dyskinetic and antiakinetic effects of antiparkinsonian treatments...
- Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activityNicolas Mallet
Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, UK
J Neurosci 28:14245-58. 2008....
- Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the ratD Kirik
Department of Physiology and Neuroscience, Lund University, Solvegatan 17, Lund, 223 62, Sweden
Exp Neurol 152:259-77. 1998....
- Nonhuman primate models of Parkinson's diseaseMarina E Emborg
Preclinical Parkinson s Research Program, Wisconsin National Primate Research Center, University of Wisconsin Madison, 1223 Capitol Court, Madison, WI 53715, USA
ILAR J 48:339-55. 2007..Adequate experimental designs, with multiple outcome measures of clinical relevance and an appropriate number of animals, are essential to minimize the limitations of models and increase their predictive clinical validity...
- Astroglial and microglial reaction after a partial nigrostriatal degeneration induced by the striatal injection of different doses of 6-hydroxydopamineR W Rodrigues
Laboratory of Neuroregeneration, Department of Anatomy, Institute of Biomedical Sciences, , Av. Prof. Lineu Prestes, , Brazil
Int J Neurosci 109:91-126. 2001..The interaction between activated glial cells may be involved in the wounding and repair events in the partial lesioned nigrostriatal system as well as in the paracrine responses to surviving dopamine neurons...
- Contribution of pre-synaptic mechanisms to L-DOPA-induced dyskinesiaM Carta
Neurobiology Unit, Department of Experimental Medical Science, Lund University, BMC A11, Solvegatan 17, 22184 Lund, Sweden
Neuroscience 198:245-51. 2011....
- Liver growth factor promotes the survival of grafted neural stem cells in a rat model of Parkinson's diseaseDiana Reimers
Servicio de Neurobiologia, Hospital Ramon y Cajal, Madrid, Spain
Curr Stem Cell Res Ther 7:15-25. 2012....
- Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's diseaseD Kirik
Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84 Lund, Sweden
Eur J Neurosci 13:1589-99. 2001....
- 6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's diseaseH Elkon
Felsenstein Medical Research Center and the Department of Neurology, Rabin Medical Center, Tel Aviv University, Petah Tikva, Israel
Cell Mol Neurobiol 21:771-81. 2001..In conclusion, our findings suggest that 6-OHDA toxicity is associated with protein degradation and ubiquitin-proteasome system activation...
- Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson diseaseTakao Yasuhara
Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
J Neurosurg 102:80-9. 2005..The authors investigated the effects of GDNF on 6-hydroxydopamine (6-OHDA)-treated dopaminergic neurons in vitro and in vivo...
- Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's diseaseY Q Xue
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Neuroscience 146:1245-58. 2007..Anti-inflammation may be one of mechanisms responsible for rhEPO neuroprotection...
- Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generationBrian P Dranka
Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI, USA
J Neurochem 122:941-51. 2012..Together these data indicate that MPP(+), rotenone, and 6-OHDA dramatically shift bioenergetic function away from the mitochondria and towards glycolysis in N27 cells...
- Isoliquiritigenin isolated from licorice Glycyrrhiza uralensis prevents 6-hydroxydopamine-induced apoptosis in dopaminergic neuronsCheol Kyu Hwang
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Biosci Biotechnol Biochem 76:536-43. 2012..These results provide the first evidence that ISL can protect dopaminergic cells under oxidative stress conditions by regulating the apoptotic process...
- Comparative effects of acute or chronic administration of levodopa to 6-OHDA-lesioned rats on the expression and phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in the striatumMin Kong
Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092 Shanghai, People s Republic of China
Neurochem Res 34:1513-21. 2009..Activated NMDA receptor NR1-mediated mechanisms are involved in the persistent expression of the motor response alterations that appear during chronic levodopa therapy of parkinsonian rats and continue after treatment withdrawal...
- Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's diseaseR K Chaturvedi
Developmental Toxicology Division, Industrial Toxicology Research Centre, Post Box 80, M G Marg Lucknow 226001, India
Neurobiol Dis 22:421-34. 2006....
- Systemic administration of an mGluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesias in a rodent model of Parkinson's diseaseGiovanna Levandis
Laboratory of Functional Neurochemistry, Interdepartmental Research Center for Parkinsons s Disease CRIMP, IRCCS C Mondino, Pavia, Italy
Neurobiol Dis 29:161-8. 2008..Our data confirm the role of glutamatergic neurotransmission in the pathogenesis of dyskinesias and the potential of mGluR5 antagonists in the treatment of l-DOPA-induced dyskinesias...
- Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the ratS Walsh
Department of Pharmacology and Therapeutics, National University of Ireland, Galway, Ireland
Neuroscience 175:251-61. 2011....
- Protective effect of hydrogen sulphide against 6-OHDA-induced cell injury in SH-SY5Y cells involves PKC/PI3K/Akt pathwayChi Xin Tiong
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Br J Pharmacol 161:467-80. 2010....
- Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegenerationA Hurtado-Lorenzo
Gene Therapeutics Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048 USA
Mol Ther 10:507-24. 2004..Differentiation and transcription factors can thus be used for the treatment of neurodegeneration by gene therapy...
- Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat modelsLi Fang Hu
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Aging Cell 9:135-46. 2010....
- Subthalamic GAD gene therapy in a Parkinson's disease rat modelJia Luo
Functional Genomics and Translational Neuroscience Laboratory, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Science 298:425-9. 2002..This strategy suggests that there is plasticity between excitatory and inhibitory neurotransmission in the mammalian brain that could be exploited for therapeutic benefit...
- Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's diseaseJames B Koprich
Center for Neuroregeneration Research, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
J Neuroinflammation 5:8. 2008..It is more likely that multiple factors converge to give rise to PD than any single cause. Here we report that inflammation can trigger degeneration of dopamine (DA) neurons in an animal model of Parkinson's disease...
- Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat modelLars M Bjorklund
Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 99:2344-9. 2002..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...
- Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine lossBonnie G Garcia
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Cereb Cortex 20:2423-32. 2010..These studies provide the first evidence to show that MSN spine loss associated with parkinsonism can be reversed and point to suppression of corticostriatal glutamate release as a means of slowing progression in Parkinson's disease...
- Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned ratsE K Y Chung
Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
J Comp Neurol 511:421-37. 2008..These results indicate that there are differential and distinct modulations of glutamate transporters after dopamine denervation in the 6-hydroxydopamine-lesioned rat...
- MK801 suppresses the L-DOPA-induced increase of glutamate in striatum of hemi-Parkinson ratsNadine Jonkers
Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
Brain Res 926:149-55. 2002..The suppression of this increase by prior administration of MK801 could represent a neuroprotective effect...
- Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic ratsVéronique Sgambato-Faure
INSERM U318, Laboratoire de Neurosciences Précliniques, CHU Pavillon B, Grenoble, France
J Neuropathol Exp Neurol 64:936-47. 2005....
- Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulbBeate Winner
Department of Neurology, University of Regensburg, Regensburg, Germany
Exp Neurol 197:113-21. 2006..This study supports the accumulating evidence that neurotransmitters play a crucial role in determining survival and differentiation of newly generated neurons...
- Dopamine depletion impairs precursor cell proliferation in Parkinson diseaseGünter U Höglinger
INSERM U289 Hôpital de la Salpetrière, F 75651 Paris, France
Nat Neurosci 7:726-35. 2004..These observations suggest that the generation of neural precursor cells is impaired in Parkinson disease as a consequence of dopaminergic denervation...
- "Passive stabilization" of striatal extracellular dopamine across the lesion spectrum encompassing the presymptomatic phase of Parkinson's disease: a voltammetric study in the 6-OHDA-lesioned ratBrian P Bergstrom
Department of Biology, Muskingum College, New Concord, Ohio, USA
J Neurochem 87:1224-36. 2003....
- Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterationsMarcelo Machado Ferro
Departamento de Farmacologia, Universidade Federal do Parana, Curitiba, Brazil
J Neurosci Methods 148:78-87. 2005..The picture of mild motor effects and robust impairment of habit learning and spatial working memory observed in MPTP-lesioned rats models the early phase of Parkinson's disease...
- Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatumY He
Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Brain Res 909:187-93. 2001..All these results suggest that microglial activation may be involved in the nigral cell degeneration in 6-OHDA induced parkinsonian mice...
- 6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolismA Storch
Department of Neurology, University of Ulm Medical School, Federal Republic of Germany
J Neural Transm 107:281-93. 2000..These results suggest that cell death induced by 6-OHDA is not due to an inhibition of mitochondrial energy supply, but probably involves production of free radicals...
- Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in ratsChristine Winter
Department of Psychiatry and Psychotherapy, Charite Campus Mitte, Germany
Behav Brain Res 184:133-41. 2007..The effects of citalopram administration on depressive behavior induced by lesions of dopaminergic brain regions furthermore suggest an involvement of serotonergic pathways in dopaminergic cell loss-induced depression...
- Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's diseaseEmma Thornton
Adelaide Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, Adelaide, South Australia
PLoS ONE 7:e34138. 2012..We propose that neurogenic inflammation contributes to dopaminergic degeneration in early experimental PD and demonstrate that an NK1 receptor antagonist may represent a novel neuroprotective therapy...
- Intrastriatal botulinum toxin abolishes pathologic rotational behaviour and induces axonal varicosities in the 6-OHDA rat model of Parkinson's diseaseAndreas Wree
Department of Anatomy, University of Rostock, Gertrudenstr 9, 18057 Rostock, Germany
Neurobiol Dis 41:291-8. 2011..Intrastriatal application of BoNT-A may antagonize localized relative functional disinhibited hypercholinergic activity in neurodegenerative diseases such as PD avoiding side effects of systemic anti-cholinergic treatment...
- C-terminal mechano-growth factor induces heme oxygenase-1-mediated neuroprotection of SH-SY5Y cells via the protein kinase Cϵ/Nrf2 pathwayArnulfo Quesada
Department of Neurobiology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, California, USA
J Neurosci Res 89:394-405. 2011....
- Arylpiperazine-mediated activation of Akt protects SH-SY5Y neuroblastoma cells from 6-hydroxydopamine-induced apoptotic and autophagic deathGordana Tovilovic
Institute for Biological Research, University of Belgrade, Despota Stefana Blvd 142, 11000 Belgrade, Serbia
Neuropharmacology 72:224-35. 2013..Because of the ability to prevent 6-OHDA induced apoptotic/autophagic cell death through activation of Akt, the investigated arylpiperazines could be potential candidates for treatment of neurodegenerative diseases...
- Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neuronsJ Rodriguez-Pallares
Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
J Neurochem 103:145-56. 2007....
- Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brainsJason Callio
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 280:18536-42. 2005..Antioxidant therapies that target this subcellular compartment may prove promising...
- Autophagy-dependent and -independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cellsKatarina Arsikin
Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia
Biochim Biophys Acta 1822:1826-36. 2012..These data suggest that oxidative stress-mediated AMPK/mTOR-dependent autophagy and AMPK/p38-dependent apoptosis could be valid therapeutic targets for neuroprotection...
- Serotonin 1B receptor stimulation reduces D1 receptor agonist-induced dyskinesiaKaren L Eskow Jaunarajs
Department of Psychology, Binghamton University, State University of New York, Binghamton, New York 13902, USA
Neuroreport 20:1265-9. 2009..These findings suggest that 5-HT1B receptor stimulation directly diminishes D1 receptor-mediated dyskinesia, implicating an important target for the treatment of L-DOPA-induced dyskinesia...
- 6-Hydroxydopamine induces mitochondrial ERK activationScott M Kulich
Department of Pathology, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
Free Radic Biol Med 43:372-83. 2007....
- Calcium-permeable AMPA receptors are involved in the induction and expression of l-DOPA-induced dyskinesia in Parkinson's diseaseChristopher Kobylecki
Faculty of Life Sciences, University of Manchester, Manchester, UK
J Neurochem 114:499-511. 2010..These data suggest that Ca(2+)-permeable AMPA receptors are critically involved in both the induction and subsequent expression of LID, and represent a potential target for anti-dyskinetic therapies...
- Partial lesion of the dopaminergic innervation of the ventral striatum induces "depressive-like" behavior of ratsKatarzyna Kuter
Department of Neuro Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
Pharmacol Rep 63:1383-92. 2011..The present study indicates that a relatively small lesion of dopaminergic terminals in the ventral striatum, which does not produce any motor disturbances, may induce "depressive-like" symptoms...
- Gene expression profiles of reactive astrocytes in dopamine-depleted striatumTakao Nakagawa
Neurotrophic Factors Section, National Institute of Neurological Disorders and Stroke, NIH, DHHS, Bethesda, MD, USA
Brain Pathol 14:275-80. 2004..Understanding these gene differences that occur in astrocytes in response to dopamine depletion should enhance our ability to promote recovery from the injury...
- Survival and early functional integration of dopaminergic progenitor cells following transplantation in a rat model of Parkinson's diseaseMichaela Hahn
Department of Stereotactic and Functional Neurosurgery, Albert Ludwigs University, Freiburg, Germany
J Neurosci Res 87:2006-19. 2009..These data highlight the complexity of graft-host interactions and provide novel insights into the dynamics of DA progenitor graft-mediated functional recovery in animal models of Parkinson's disease...
- Bilateral regulation of glutamate tissue and extracellular levels in caudate-putamen by midbrain dopamine neuronsN Lindefors
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
Neurosci Lett 115:248-52. 1990..The results indicate that mesencephalic dopamine neurons regulate neuronal glutamate in ipsilateral as well as contralateral caudate-putamen...
- Differential astroglial activation in 6-hydroxydopamine models of Parkinson's diseaseJeannette Henning
Department of Neurology, University of Rostock, Germany
Neurosci Res 62:246-53. 2008....
- BN82451 attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's diseaseBrigitte Spinnewyn
Ipsen Innovation, Neurology, Les Ulis, France
Neuropharmacology 60:692-700. 2011..The data demonstrate that BN82451 effectively attenuates LID and the associated molecular alterations in an animal model of PD and may represent a treatment option for managing dyskinesia...
- Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's diseaseIsabel Lastres-Becker
Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
Neurobiol Dis 19:96-107. 2005....
- Evaluation of the neurotoxic/neuroprotective role of organoselenides using differentiated human neuroblastoma SH-SY5Y cell line challenged with 6-hydroxydopamineFernanda Martins Lopes
Departamento de Bioquimica, Laboratório 24, ICBS Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS 90035 003, Brazil
Neurotox Res 22:138-49. 2012....
- Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's diseaseEunju Shin
Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
Neurobiol Dis 47:393-406. 2012..Together, these results point to a critical role of both 5-HT(1) and D(2) receptors in the modulation of GID, and suggest that 5-HT neurons exert a modulatory role in the development of this side effect of neuronal transplantation...
- Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: motor impairments identify extent of dopamine depletion at three different lesion sitesAndreas Heuer
Brain Repair Group, School of Bioscience, Cardiff University, Cardiff, Wales, UK
Behav Brain Res 228:30-43. 2012....
- Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamineRonise M Santiago
Laboratorio de Fisiologia e Farmacologia do Sistema Nervoso Central, Departamento de Farmacologia, Universidade Federal do Parana, Curitiba, PR, Brasil
Prog Neuropsychopharmacol Biol Psychiatry 34:1104-14. 2010..Moreover, DA and 5-HT strongly correlated with "emotional" impairments suggesting an important participation of these neurotransmitters in anhedonia and behavioral despair after nigral lesions promoted by the neurotoxins...
- Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonismBarbara Picconi
Dipartimento di Neuroscienze, Clinica Neurologica, Universita di Roma Tor Vergata, Rome, Italy
Brain 127:1661-9. 2004....
- Neuroprotection of the nigrostriatal dopaminergic neurons by melatonin in hemiparkinsonium ratS Singh
Department of Physiology, Maulana Azad Medical College, New Delhi, India
Indian J Med Res 124:419-26. 2006..Therefore in the present study the effect of neuroprotectory melatonin was tested against 6-hydroxydopamine (6-OHDA) neurotoxicity for striatal dopaminergic neurons in the rat...
- Dopamine D3 receptor stimulation underlies the development of L-DOPA-induced dyskinesia in animal models of Parkinson's diseaseNaomi P Visanji
Toronto Western Research Institute, 399 Bathurst Street, MC11 419, Toronto, Ontario M5T 2S8, Canada
Neurobiol Dis 35:184-92. 2009..Our data suggest a role for D3 receptors in the development of LID and suggest that initiating L-DOPA treatment with a D3 antagonist may reduce the development of LID in PD...
- High-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated ratsEmilie Lacombe
Institut National de la Sante et de la Recherche Medicale, Unite 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement, Grenoble, France
Eur J Neurosci 26:1670-80. 2007..These new neurochemical data suggest that STN-HFS interferes with L-DOPA effects, probably synergically, by stabilizing dopamine levels in the striatum and shed light on the mechanisms of STN-HFS in PD...
- Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brainLachlan H Thompson
Division of Neurobiology, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, S 22184 Lund, Sweden
Exp Neurol 213:220-8. 2008....
- Functional reorganization of the presynaptic dopaminergic terminal in parkinsonismB P Bergstrom
Department of Biology, Neuroscience Program, Muskingum University, New Concord, OH 43762, USA
Neuroscience 193:310-22. 2011..This novel neuroadaptation may contribute to early preclinical normalization of function and help resolve discrepant findings regarding compensatory changes in DA release during progression of the parkinsonian state...
- Impaired acquisition of skilled behavior in rotarod task by moderate depletion of striatal dopamine in a pre-symptomatic stage model of Parkinson's diseaseTaichi Ogura
Division of Brain Science, Graduate School of Medical Science, Kitasato University, Sagamihara 228 8555, Japan
Neurosci Res 51:299-308. 2005..Based on these results, we concluded that the striatum-based function underlying the acquisition of skilled behaviors or sensorimotor learning may be more vulnerable to dopamine depletion than the motor control...
- Developing a preclinical model of Parkinson's disease: a study of behaviour in rats with graded 6-OHDA lesionsL Truong
Department of Pharmacology, Institute for Biochemical Research, Bosch Building, School of Medical Sciences, University of Sydney, NSW 2006, Australia
Behav Brain Res 169:1-9. 2006..This graded model can be useful for testing potential neuroprotective compounds for PD...
- Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson's diseaseRanjita Betarbet
Department of Neurology and the Center for Neurodegenerative Disease, Emory University, Atlanta GA 30322, USA
Exp Neurol 187:76-85. 2004..Furthermore, the alterations observed in protein kinase A-dependent phosphorylation of NR1 are suggestive of receptor internalization and subcellular trafficking of NR1 in response to increased striatal glutamatergic activity...
- Early inhibition of TNFalpha increases 6-hydroxydopamine-induced striatal degenerationCarmelina Gemma
James A Haley Veterans Administration Hospital, Tampa, FL, USA
Brain Res 1147:240-7. 2007..These findings suggest that TNF release is neuroprotective in the early stages of injury but becomes neurotoxic when chronically induced...
- Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: effects of subthalamotomy and levodopa treatmentGaizka Bilbao
Department of Neurosurgery, Cruces Hospital E 48903, Bizkaia, Spain
Brain Res 1084:175-84. 2006..In this model, subthalamotomy does not modify the firing pattern while levodopa treatment efficiently restores normal firing of SNpc neurons and does not appear to be toxic to them...
- Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's diseaseMarie Therese Armentero
Laboratory of Functional Neurochemistry, IRCCS Neurological Institute C Mondino, Via Mondino, 2, 27100 Pavia, Italy
Neurobiol Dis 22:1-9. 2006..Specific modulation of STN hyperactivity obtained with mGluR5 blockade may, therefore, open interesting perspectives for the use of this class of compounds in the treatment of Parkinson's disease...
- Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced deathBarbara Monti
Department of Biology, University of Bologna, Bologna, Italy
J Neurochem 103:518-30. 2007..These results are relevant to more precisely define the role of alpha-synuclein in neuronal cells and to better understand its putative involvement in neurodegeneration...
- Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and placeAndrew J D Nelson
School of Psychology, University of Nottingham, Nottingham, England
Behav Neurosci 124:789-99. 2010..These results suggest that dopamine function within distinct subregions of the NAc plays dissociable roles in the modulation of memory for objects and place...
- Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's diseaseM T Tadaiesky
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Campus Universitario, Trindade, Florianopolis, SC, Brazil
Neuroscience 156:830-40. 2008....
- Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's diseaseGaëlle Bouchez
INSERM U930, Laboratory Biophysique médicale and pharmaceutique, UFR Pharmacie, 31 Avenue Monge, Tours, France
Neurochem Int 52:1332-42. 2008..This cellular approach might be a restorative therapy in Parkinson's disease...
- Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEKSusana D Ugarte
Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci Res 73:105-12. 2003..These studies suggest that GDNF can protect dopaminergic cells against some but not all aspects of 6-OHDA-induced toxicity by acting through both PI3K and MAPK signaling pathways...
- Intrastriatal infusion of liver growth factor stimulates dopamine terminal sprouting and partially restores motor function in 6-hydroxydopamine-lesioned ratsDiana Reimers
Servicio de Neurobiologia, Hospital Ramon y Cajal, 28034 Madrid, Spain
J Histochem Cytochem 54:457-65. 2006..As apomorphine-induced rotational behavior was also reduced in these animals, we propose LGF as a novel factor that, when delivered to the striatum, may be useful in the treatment of Parkinson's disease...
- Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult micePeng Yang
Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville, Louisville, Kentucky 40292, USA
J Neurosci 28:2231-41. 2008..Because CNTF is predominantly expressed in the nervous system, this mechanism and the ability to pharmacologically modulate it have implications for Parkinson's disease and cell-replacement therapies for other disorders...
- Serotonergic neurons mediate ectopic release of dopamine induced by L-DOPA in a rat model of Parkinson's diseaseSylvia Navailles
Universite de Bordeaux, Unité Mixte de Recherche Centre National de la Recherche Scientifique 5227, Centre Hospitalier Universitaire de Bordeaux, 33076 Bordeaux Cedex, France
Neurobiol Dis 38:136-43. 2010..These data demonstrate that l-DOPA induces an ectopic release of dopamine due to serotonergic neurons. The new pattern of dopamine transmission created by l-DOPA may contribute to the benefit and side effects of l-DOPA...
- Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in miceRuxandra Iancu
Neuronal Survival Unit, Wallenberg Neuroscience Centre, Department of Experimental Medical Sciences, Lunds University, BMC A10, 22184 Lund, Sweden
Behav Brain Res 162:1-10. 2005..This mouse model offers the opportunity to use transgenic mouse strains and study the interactions between genes of interest and toxins in relation to Parkinson's disease etiology in the future...
- Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson's diseaseLilia Marinova-Mutafchieva
Parkinson s Disease Research Group, Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London, UK
J Neurochem 110:966-75. 2009..This study suggests that activation of microglia precedes DA neuronal cell loss and neurons undergoing degeneration may be phagocytosed prematurely by phagocytic microglia...
- Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's diseaseMerja H Voutilainen
Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
J Neurosci 29:9651-9. 2009..Our results suggest that MANF is readily distributed throughout the striatum and has significant therapeutic potential for the treatment of PD...
- Mobilization of neural stem cells and generation of new neurons in 6-OHDA-lesioned rats by intracerebroventricular infusion of liver growth factorRafael Gonzalo-Gobernado
Servicio de Neurobiologia, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, 28034 Madrid, Spain
J Histochem Cytochem 57:491-502. 2009..Considering that this factor also promotes neuronal migration into damaged tissue, we propose LGF as a novel factor useful for neuronal replacement in neurodegenerative diseases...
- Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cellsElisabeth M Chalovich
Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Biol Chem 281:17870-81. 2006....
- Combined toxicity of prenatal bacterial endotoxin exposure and postnatal 6-hydroxydopamine in the adult rat midbrainZ D Ling
Department of Pharmacology, 1735 West Harrison Street, Room 410, Rush University Medical Center, Chicago, IL 60612, USA
Neuroscience 124:619-28. 2004..The results suggest that individuals exposed to LPS prenatally, as might occur had their mother had bacterial vaginosis, would be at increased risk for Parkinson's disease...
- 6-Hydroxydopamine lesion of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial mazeM Bubser
Universitat Tubingen, Abteilung Neuropharmakologie, F R G
Behav Brain Res 37:157-68. 1990....
- Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's diseaseHong Yuan
Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
J Neurosci Methods 144:35-45. 2005..However, the partial denervation renders its quite suitable for mimicking early stage Parkinson's disease, and is thus suitable for testing possible neuroprotective and neurotrophic drugs...
- Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivoAnthony C Vernon
Department of Cellular and Molecular Neuroscience, Faculty of Medicine, Imperial College London, Charing Cross Campus, London, UK
J Neurochem 103:1075-91. 2007....
- Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imagingF Cicchetti
Neuroregeneration Laboratory, MRC119, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Eur J Neurosci 15:991-8. 2002..These data support the hypothesis that inflammation is a significant component of progressive dopaminergic degeneration that can be monitored by PET imaging...
- Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptorsMaria Grazia Morgese
Department of Biomedical Sciences, University of Foggia, Viale Luigi Pinto 1, 71100 Foggia, Italy
Exp Neurol 208:110-9. 2007..Our data indicate that pharmacological blockade of TRPV1 receptors unmasks the anti-dyskinetic effects of FAAH inhibitors and that CB(1) and TRPV1 receptors play opposite roles in levodopa-induced dyskinesias...
- Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson diseaseOfer Sadan
Laboratory of Neurosciences, Felsenstein Medical Research Center, Department of Neurology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Stem Cells Dev 18:1179-90. 2009..We therefore conclude that the induced MSC have a therapeutic potential for neurodegenerative processes and diseases, both by the NTFs secretion and by the migratory trait toward the diseased tissue...
- Timecourse of striatal re-innervation following lesions of dopaminergic SNpc neurons of the ratD Stanic
Department of Medicine, Monash University, Monash Medical Centre, Clayton, Australia
Eur J Neurosci 18:1175-88. 2003..These studies provide insights into the processes that regulate sprouting responses in the central nervous system following injury...
- Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine systemIngrid Stromberg
Department of Integrative Medical Biology, Umea University, S 901 87 Umea, Sweden
Exp Neurol 196:298-307. 2005..In conclusion, enhanced striatal dopamine recovery appeared in animals treated with diet enriched in antioxidants and anti-inflammatory phytochemicals and coincided with an early, transient increase in OX-6-positive microglia...
- Time-course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6-hydroxydopamine in the rat: new clues from an old modelFabio Blandini
Laboratory of Functional Neurochemistry, IRCCS Neurological Institute C Mondino, Pavia, Italy
Eur J Neurosci 25:397-405. 2007....
- Dopamine D4 Receptor in Sustained AttentionKehong Zhang; Fiscal Year: 2003..The findings may also provide a pharmacological basis for innovative treatment for ADHD to replace stimulant therapy. ..
- Effects of Stress on Pathology of Parkinson's DiseaseGERLINDE METZ; Fiscal Year: 2004..These approaches will provide the opportunity to understand factors involved in the pathology of PD and to develop novel therapeutic strategies for neurodegenerative motor disorders. ..
- Molecular Basis of D1 and D2 PrimingAlexia Pollack; Fiscal Year: 2003..Elucidation of this mechanism could lead to treatment strategies aimed to prevent these dyskinesias, which would, in turn, lengthen the time that dopamine replacement therapy is effective to treat patients with PD. ..
- BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSIONDavid Wirtshafter; Fiscal Year: 2003..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
- TRAINING FACULTY TO TEACH SURVIVAL SKILLS AND ETHICSMichael Zigmond; Fiscal Year: 2005..Efforts will be made to promote diversity with regard to the demographics of both the workshop participants and those they serve. Instruction will be provided by the PI's together with a highly qualified group of trainers. ..
- Lateral Hypothalamus, Dopamine and Ingestive BehaviorDavid Wirtshafter; Fiscal Year: 2007..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
- Developmental Stress and Vulnerability to Brain InjuryMichael Zigmond; Fiscal Year: 2004..Moreover, the methods and reagents that we develop will be made available to others in the field. ..
- AGING AND 6 HYDROXYDOPAMINE NEUROTOXICITYWayne Cass; Fiscal Year: 2005....
- Calcitriol and Methamphetamine NeurotoxicityWayne Cass; Fiscal Year: 2008..Furthermore, if calcitriol is effective, it could have therapeutic applications in other disease processes where there is a loss of monoamine neurons, such as in Parkinson's disease. [unreadable] [unreadable] [unreadable]..
- Development Stress, Exercise, and Vulnerability to Neuronal InjuryMichael J Zigmond; Fiscal Year: 2010....
- Calcitriol-Induced Restoration of Dopamine in a Model of Parkinson's DiseaseWayne Cass; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ADAPTIVE BEHAVIOR AND BRAIN MONOAMINESMichael Zigmond; Fiscal Year: 2002..The longer-term objectives of this project are to provide new insights into the basic neurobiology of LC neurons and the psychopathology that develops from chronic stress. ..
- Environmental Toxicants and NeurodegenerationKim Tieu; Fiscal Year: 2010..In addition, these studies may provide significant insights into a novel mechanism that contributes to the pattern of cell death as seen in neurodegenerative disorders such as sporadic Parkinson's disease. ..
- Mechanisms underlying reward-related synaptogenesisGloria E Meredith; Fiscal Year: 2010..abstract_text> ..
- Flumazenil on Multiple Stress and Withdrawal AnxietyGeorge Breese; Fiscal Year: 2007....
- Imaging stem cell implants in neurodegenerative diseaseLorraine Iacovitti; Fiscal Year: 2007..This will provide vital information in the animal model of PD, allow us to longitudinally follow DA neuron regeneration, and, most importantly, will be translatable to clinical human studies using similar techniques. ..
- Mitochondrial respiratory uncoupling and the pathogenes*William Sivitz; Fiscal Year: 2006..This is mediated by one or more UCP subtype. 4. Altered mitochondrial coupling and consequent changes in mitochondrial ROS formation alter endothelial cell generation of nitric oxide. ..
- The Rochester Center for Mind-Body ResearchJan Moynihan; Fiscal Year: 2006..By the end of the award period, we will be a mature, established Center with a submitted program project or Center grant application. ..
- Using Stem Cells in Animal Models of Parkinson's DiseaseLorraine Iacovitti; Fiscal Year: 2006..abstract_text> ..
- NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIESNeal Swerdlow; Fiscal Year: 2006....
- Blood Brain Barrier Dysfunction in Parkinson's DiseasesPaul M Carvey; Fiscal Year: 2010..These findings would provide an entirely new hypothesis for progression pa hogenesis and identify new targets for therapeutic intervention in PD designed arou d affecting BBB integrity. ..
- TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENESKAREN O MALLEY; Fiscal Year: 2007..Knowledge gained from these studies may offer new routes for therapeutic intervention. ..
- STUDIES OF PURIFIED DOPAMINE NEURONSLorraine Iacovitti; Fiscal Year: 2007..This work will hopefully lay the foundation for the development of therapeutic treatments for Parkinson's and other diseases involving compromised DA systems. ..
- MODULATION OF DOPAMINE AUTORECEPTOR FUNCTION BY COCAINEKAREN O MALLEY; Fiscal Year: 2001..Taken together these studies will significantly extend our ongoing efforts to understand the complex receptor/presynaptic effector interactions involved in the reinforcing and behavioral sensitization effects of cocaine. ..
- Mindfulness to Improve Elders' Immune and Health StatusJan Moynihan; Fiscal Year: 2008..The findings of this RCT will have implications for the conceptualization, refinement, and dissemination of psychosocial interventions aimed at slowing the rate of immunosenescence. ..
- Stress Sensitization of CRF-Induced Withdrawal BehaviorsGeorge Breese; Fiscal Year: 2009..New treatment strategies could emerge from such knowledge ..
- Functional Consequences of Nuclear mGlu5 Receptor ActivationKAREN O MALLEY; Fiscal Year: 2008..unreadable] [unreadable]..
- Neurophysiology and Biomechanics of Urethra in Stress Urinary IncontinenceNaoki Yoshimura; Fiscal Year: 2008..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
- Hybrid Drugs: Novel Pharmacotherapy for ADHDFRANK TARAZI; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- NEUROPROTECTIVE STRATEGIES AGAINST OXIDATIVE DAMAGEAnumantha Kanthasamy; Fiscal Year: 2009....
- Neurotrophic factors and HIV-mediated neuronal injuryItalo Mocchetti; Fiscal Year: 2008....
- APOPTOSIS IN SUBSTANTIA NIGRARobert E Burke; Fiscal Year: 2010..abstract_text> ..
- Chronic Alcohol & AIDS Impact on Muscle WastingPatricia Molina; Fiscal Year: 2006..abstract_text> ..
- Cytokine and MAP Kinase Involvement in Neuropathic PainLinda Sorkin; Fiscal Year: 2008..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
- Zebrafish Screen for Neuroprotective Anti-oxidantsChuenlei Parng; Fiscal Year: 2005..Assessment of drug effects in a convenient vertebrate model, prior to evaluation in a complex system, such as mouse, can potentially streamline the drug development process and dramatically reduce costs. ..
- NOVEL USE OF ZEBRAFISH FOR APOPTOSIS ASSAYChuenlei Parng; Fiscal Year: 2004..Complementary visual and flow cytometry based assays will also be developed to provide comprehensive analysis of apoptosis in zebrafish. ..
- SCIENCE PARTNERSHIPS FOR HANDS-ON LEARNING -PHASE IIJan Moynihan; Fiscal Year: 2003..Teachers will have use of a "lending library" of science equipment and supplies to perform activities in their classrooms. ..
- Chronic Ethanol Effects on CNS Opiate ReceptorsLinda Saland; Fiscal Year: 2003..It will also be possible to study the functional changes that may occur in the receptors after withdrawal from consumption. A future potential may be then to target delta receptors for treating chronic alcoholism. ..
- Lower urinary tract dysfunction in Parkinson's diseaseNaoki Yoshimura; Fiscal Year: 2003..This is a high priority in the urologic care of patients with Parkinson's disease. ..
- NEUROTOXINS, NEURAL INJURY AND OBESITYPushpa Kalra; Fiscal Year: 2003..abstract_text> ..
- MOLECULAR BIOLOGY OF ETHANOL ACTION ON RECEPTORSGeorge Breese; Fiscal Year: 2002..Further, based upon structural analysis of ethanol's action on protein-protein inter-actions for the receptors, results may ultimately allow us to predict other protein-protein interactions influenced by ethanol. ..
- FACTORS REGULATING TYROSINE HYDROXYLASE GENE EXPRESSIONLorraine Iacovitti; Fiscal Year: 2002..abstract_text> ..
- Alcoholism and Disease: Immune /Pathological MechanismsPatricia Molina; Fiscal Year: 2002..The proceedings of these symposia will be published and a summary report to the NIAAA will be prepared. ..
- Novel CRF antagonists for inflammation and painMARK LINDNER; Fiscal Year: 2002..Orally active forms of a small molecule CRF receptor would provide a novel therapeutic strategy for indications of acute and chronic inflammation and inflamatory pain. ..
- Immunoregulation by Endogenous OpioidsJan Moynihan; Fiscal Year: 2004..Specific Aim 4: To determine if C57B1/6 mice, which do not have altered immune responses to KLH following stress odor exposure, have evidence of elevated endogenous opioids following odor exposure. ..
- Signaling By Nuclear G-Protein Coupled ReceptorsKAREN O MALLEY; Fiscal Year: 2005..Direct nuclear calcium regulation represents a novel signaling strategy by which intracellular receptors such as mGlu5 may play a pivotal role in generating and shaping intracellular Ca2+ signals ..
- ASSAY FOR DETERMINING DRUG TOXICITYChuenlei Parng; Fiscal Year: 2004..abstract_text> ..
- Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNANaoki Yoshimura; Fiscal Year: 2004..This research project is important to provide a solid basis for potential future clinical application. ..
- Gene Therapy, Neural Grafts & Parkinson's DiseaseDAVID YUREK; Fiscal Year: 2005..These studies will also determine if combinations of viral vectors expressing different neurotrophic factors can be used to improve the therapeutic effects of dopamine grafts. ..
- Cardiotoxicity Drug Screening Using ZebrafishChuenlei Parng; Fiscal Year: 2004..Zebrafish drug screens can serve as an intermediate step between cell-based and mammalian testing, streamlining the drug development timeline. ..
- Ca permeable non-NMDAr: New spinal sensitization pathwayLinda Sorkin; Fiscal Year: 2005..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
- MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODELCLARA SANUDO PENA; Fiscal Year: 2002..Behavioral, biochemical, and physiological studies will be conducted in parallel to test this possibility. It will also help integrate the cannabinergic system with the current knowledge of basal ganglia physiology. ..
- EFECTS OF STRESS IN IMMUNOCOMPROMISED HOSTSJan Moynihan; Fiscal Year: 2003..In turn, this will result in prolonged allograft survival. In contrast, the immunocompromised animal will have poorer immune responses to an opportunistic pathogen (HSV-1). ..
- Fetal & Adolescent Nicotine Effects on CNS 5HT SystemsTheodore Slotkin; Fiscal Year: 2003..abstract_text> ..
- ALPHA-1 ADRENERGIC SYSTEM IN ACTIVITY AND DEPRESSIONEric A Stone; Fiscal Year: 2010..The research will likely identify the EPI/alpha-1 system as a new and important target for antidepressant and antistress medications ..
- Basal ganglia modulation of trigeminal intralaminar nuclei thalamic activityEric Chudler; Fiscal Year: 2007..These studies will help explain the complex sensory symptoms exhibited by patients with PD and may suggest new treatment strategies to alleviate such pain. [unreadable] [unreadable] [unreadable]..
- Estrogenic LXR Alpha Response /Cholesterol HomeostasisPhillip Kramer; Fiscal Year: 2003..abstract_text> ..
- LENTIVIRAL DELIVERY OF GDNF AND BCL-2 IN PD MODELMarina Emborg; Fiscal Year: 2003..These studies will serve as the preclinical foundation to determine whether this in vivo method to deliver these potent trophic factor and antiapoptotic genes will be suitable for testing in patients with PD. ..
- Estrogenic Regulation of Inflammation Related to TMJDPhillip Kramer; Fiscal Year: 2006..The function of estrogen receptors ER alpha and/or ER beta will be directly addressed pharmacologically (e.g., antiestrogen) and through mutation studies of the Fc gamma RIIIA promoter. ..
- Antidepressants and Fibroblast Growth FactorItalo Mocchetti; Fiscal Year: 2006..Data from this proposal may help elucidate the therapeutic efficacy of antidepressants in affective disorders. [unreadable] [unreadable]..
- Neuronal transport of gp120Italo Mocchetti; Fiscal Year: 2005..abstract_text> ..
- DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEMTheodore Slotkin; Fiscal Year: 2003....
- INTERNET NEUROSCIENCE RESOURCE - PHASE IIEric Chudler; Fiscal Year: 2002..An Internet version of the Neuroscience Resource will continue to be available. An on-line survey and analysis of daily use log files will determine how the Internet Neuroscience Resource is utilized. ..
- MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITYTheodore Slotkin; Fiscal Year: 2004..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..