dopamine

Summary

Summary: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from tyrosine and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

Top Publications

  1. pmc Modulation of striatal projection systems by dopamine
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 34:441-66. 2011
  2. ncbi A neural substrate of prediction and reward
    W Schultz
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 275:1593-9. 1997
  3. pmc The dopamine hypothesis of schizophrenia: version III--the final common pathway
    Oliver D Howes
    Positron Emission Tomography PET Psychiatry Group, Medical Research Council MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK
    Schizophr Bull 35:549-62. 2009
  4. pmc A MicroRNA feedback circuit in midbrain dopamine neurons
    Jongpil Kim
    Departments of Pathology and Neurology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons 15 403, 630 West 168th Street, New York, NY 10032, USA
    Science 317:1220-4. 2007
  5. ncbi By carrot or by stick: cognitive reinforcement learning in parkinsonism
    Michael J Frank
    Department of Psychology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309 0345, USA
    Science 306:1940-3. 2004
  6. ncbi Dopamine, learning and motivation
    Roy A Wise
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 5:483-94. 2004
  7. doi Neuroinflammation in Parkinson's disease: a target for neuroprotection?
    Etienne C Hirsch
    INSERM, UMRS 975, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Experimental Therapeutics of Neurodegeneration, Paris, France
    Lancet Neurol 8:382-97. 2009
  8. pmc Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    Venu M Nemani
    Departments of Neurology and Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 65:66-79. 2010
  9. pmc Dopamine in motivational control: rewarding, aversive, and alerting
    Ethan S Bromberg-Martin
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuron 68:815-34. 2010
  10. pmc Inverted-U-shaped dopamine actions on human working memory and cognitive control
    Roshan Cools
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biol Psychiatry 69:e113-25. 2011

Research Grants

Detail Information

Publications372 found, 100 shown here

  1. pmc Modulation of striatal projection systems by dopamine
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 34:441-66. 2011
    ..Twenty years ago, investigators proposed that the striatum's ability to use dopamine (DA) rise and fall to control action selection was due to the segregation of D(1) and D(2) DA receptors in direct-..
  2. ncbi A neural substrate of prediction and reward
    W Schultz
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 275:1593-9. 1997
    ..Taken together, these findings can be understood through quantitative theories of adaptive optimizing control...
  3. pmc The dopamine hypothesis of schizophrenia: version III--the final common pathway
    Oliver D Howes
    Positron Emission Tomography PET Psychiatry Group, Medical Research Council MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK
    Schizophr Bull 35:549-62. 2009
    The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry...
  4. pmc A MicroRNA feedback circuit in midbrain dopamine neurons
    Jongpil Kim
    Departments of Pathology and Neurology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons 15 403, 630 West 168th Street, New York, NY 10032, USA
    Science 317:1220-4. 2007
    ..We propose a role for this feedback circuit in the fine-tuning of dopaminergic behaviors such as locomotion...
  5. ncbi By carrot or by stick: cognitive reinforcement learning in parkinsonism
    Michael J Frank
    Department of Psychology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309 0345, USA
    Science 306:1940-3. 2004
    To what extent do we learn from the positive versus negative outcomes of our decisions? The neuromodulator dopamine plays a key role in these reinforcement learning processes...
  6. ncbi Dopamine, learning and motivation
    Roy A Wise
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 5:483-94. 2004
  7. doi Neuroinflammation in Parkinson's disease: a target for neuroprotection?
    Etienne C Hirsch
    INSERM, UMRS 975, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Experimental Therapeutics of Neurodegeneration, Paris, France
    Lancet Neurol 8:382-97. 2009
    ....
  8. pmc Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    Venu M Nemani
    Departments of Neurology and Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 65:66-79. 2010
    ..Increased levels of alpha-synuclein thus produce a specific, physiological defect in synaptic vesicle recycling that precedes detectable neuropathology...
  9. pmc Dopamine in motivational control: rewarding, aversive, and alerting
    Ethan S Bromberg-Martin
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuron 68:815-34. 2010
    Midbrain dopamine neurons are well known for their strong responses to rewards and their critical role in positive motivation...
  10. pmc Inverted-U-shaped dopamine actions on human working memory and cognitive control
    Roshan Cools
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biol Psychiatry 69:e113-25. 2011
    Brain dopamine (DA) has long been implicated in cognitive control processes, including working memory...
  11. ncbi Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:533-42. 2005
    ..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity...
  12. pmc The nature of dopamine dysfunction in schizophrenia and what this means for treatment
    Oliver D Howes
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, Camberwell, UK
    Arch Gen Psychiatry 69:776-86. 2012
    ..for many patients, and despite 5 decades of drug discovery, all of the treatments rely on the same mechanism: dopamine D(2) receptor blockade...
  13. pmc Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli
    Stephan Lammel
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Lokey Stem Cell Research Building, 265 Campus Drive, Room G1021, Stanford, CA 94305 5453, USA
    Neuron 70:855-62. 2011
    Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli...
  14. ncbi Transplantation of embryonic dopamine neurons for severe Parkinson's disease
    C R Freed
    Division of Clinical Pharmacology, University of Colorado School of Medicine, Denver 80262, USA
    N Engl J Med 344:710-9. 2001
    BACKGROUND: Transplantation of human embryonic dopamine neurons into the brains of patients with Parkinson's disease has proved beneficial in open clinical trials...
  15. ncbi The mesolimbic dopamine reward circuit in depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 59:1151-9. 2006
    ..ventral striatum) and its dopaminergic input from the ventral tegmental area (VTA), which form the mesolimbic dopamine system, in depression...
  16. ncbi Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor
    Jubao Duan
    Schizophrenia Genetics Research Program, Department of Psychiatry, The University of Chicago, Jules F Knapp Medical Research Center, Chicago, IL 60637, USA
    Hum Mol Genet 12:205-16. 2003
    ..altered the predicted mRNA folding, led to a decrease in mRNA stability and translation, and dramatically changed dopamine-induced up-regulation of DRD2 expression...
  17. ncbi Discrete coding of reward probability and uncertainty by dopamine neurons
    Christopher D Fiorillo
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 299:1898-902. 2003
    ..Using distinct stimuli to indicate the probability of reward, we found that the phasic activation of dopamine neurons varied monotonically across the full range of probabilities, supporting past claims that this response ..
  18. ncbi Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    B Giros
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 379:606-12. 1996
    Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels...
  19. pmc Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
    Yanping Li
    Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA
    Nat Neurosci 12:826-8. 2009
    ..features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection...
  20. ncbi What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
    K C Berridge
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109
    Brain Res Brain Res Rev 28:309-69. 1998
    What roles do mesolimbic and neostriatal dopamine systems play in reward? Do they mediate the hedonic impact of rewarding stimuli? Do they mediate hedonic reward learning and associative prediction? Our review of the literature, together ..
  21. ncbi The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity
    Clay B Holroyd
    Neuroscience Program, University of Illinois at Urbana Champaign, USA
    Psychol Rev 109:679-709. 2002
    ..account of 2 neural systems concerned with the development and expression of adaptive behaviors: a mesencephalic dopamine system for reinforcement learning and a "generic" error-processing system associated with the anterior cingulate ..
  22. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
    Anatomical and functional refinements of the meso-limbic dopamine system of the rat are discussed...
  23. ncbi C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
    E R Sawin
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 26:619-31. 2000
    ..This basal slowing response is mediated by a dopamine-containing neural circuit that senses a mechanical attribute of bacteria and may be an adaptive mechanism that ..
  24. pmc Two types of dopamine neuron distinctly convey positive and negative motivational signals
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 459:837-41. 2009
    Midbrain dopamine neurons are activated by reward or sensory stimuli predicting reward. These excitatory responses increase as the reward value increases...
  25. pmc A selective role for dopamine in stimulus-reward learning
    Shelly B Flagel
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Michigan, USA
    Nature 469:53-7. 2011
    ..in the incentive motivational properties they attribute to food cues to probe the role of the neurotransmitter dopamine in stimulus-reward learning...
  26. ncbi Oxidative stress in Parkinson's disease
    Peter Jenner
    Neurodegenerative Diseases Research Centre, GKT School of Biomedical Sciences, King s College, London, United Kingdom
    Ann Neurol 53:S26-36; discussion S36-8. 2003
    Oxidative stress contributes to the cascade leading to dopamine cell degeneration in Parkinson's disease (PD)...
  27. doi Influence of phasic and tonic dopamine release on receptor activation
    Jakob K Dreyer
    Department for Neuroscience and Pharmacology, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Neurosci 30:14273-83. 2010
    Tonic and phasic dopamine release is implicated in learning, motivation, and motor functions...
  28. doi New insights into the relationship between dopamine, beta oscillations and motor function
    Ned Jenkinson
    Nuffield Department of Clinical Neuroscience, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Trends Neurosci 34:611-8. 2011
    ..Oscillatory beta activity is in turn modulated by net dopamine levels at sites of cortical input to the basal ganglia...
  29. pmc PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
    Joo Ho Shin
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 144:689-702. 2011
    A hallmark of Parkinson's disease (PD) is the preferential loss of substantia nigra dopamine neurons...
  30. doi Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
    Massimiliano Caiazzo
    Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy
    Nature 476:224-7. 2011
    ..dopaminergic neurons has been shown to be efficient in restoring motor symptoms in conditions of dopamine deficiency...
  31. pmc Writing memories with light-addressable reinforcement circuitry
    Adam Claridge-Chang
    Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Cell 139:405-15. 2009
    ..Olfactory conditioning in Drosophila requires direct dopamine action on intrinsic mushroom body neurons, the likely storage sites of olfactory memories...
  32. doi Anatomically distinct dopamine release during anticipation and experience of peak emotion to music
    Valorie N Salimpoor
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Nat Neurosci 14:257-62. 2011
    ..scanning, combined with psychophysiological measures of autonomic nervous system activity, we found endogenous dopamine release in the striatum at peak emotional arousal during music listening...
  33. pmc TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
    Mickael Decressac
    Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 110:E1817-26. 2013
    ..that defects in the autophagy-mediated clearance of α-synuclein contribute to the progressive loss of nigral dopamine neurons...
  34. pmc Start/stop signals emerge in nigrostriatal circuits during sequence learning
    Xin Jin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892 9412, USA
    Nature 466:457-62. 2010
    ..These results have important implications for understanding the functional organization of actions and the sequence initiation and termination impairments observed in basal ganglia disorders...
  35. doi Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons
    Sarah Threlfell
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK
    Neuron 75:58-64. 2012
    Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns...
  36. pmc Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model
    Won Seok Choi
    Department of Environmental and Occupational Health Sciences, Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98195, USA
    J Cell Biol 192:873-82. 2011
    Mitochondrial complex I dysfunction is regarded as underlying dopamine neuron death in Parkinson's disease models...
  37. pmc Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
    Adriana Sánchez-Danés
    Institute for Biomedicine IBUB, University of Barcelona, Barcelona, Spain
    EMBO Mol Med 4:380-95. 2012
    ..Our study provides an iPSC-based in vitro model that captures the patients' genetic complexity and allows investigation of the pathogenesis of both sporadic and familial PD cases in a disease-relevant cell type...
  38. ncbi A neuropsychological theory of positive affect and its influence on cognition
    F G Ashby
    Department of Psychology, University of California, Santa Barbara 93106, USA
    Psychol Rev 106:529-50. 1999
    ..that accounts for many of these effects by assuming that positive affect is associated with increased brain dopamine levels...
  39. ncbi Lateral habenula as a source of negative reward signals in dopamine neurons
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 447:1111-5. 2007
    Midbrain dopamine neurons are key components of the brain's reward system, which is thought to guide reward-seeking behaviours...
  40. pmc The mysterious motivational functions of mesolimbic dopamine
    John D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuron 76:470-85. 2012
    Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse...
  41. ncbi The principal features and mechanisms of dopamine modulation in the prefrontal cortex
    Jeremy K Seamans
    Department of Physiology, MUSC, 173 Ashley Avenue, Suite 403, Charleston, SC 29425, USA
    Prog Neurobiol 74:1-58. 2004
    Mesocortical [corrected] dopamine (DA) inputs to the prefrontal cortex (PFC) play a critical role in normal cognitive process and neuropsychiatic pathologies...
  42. ncbi 'Rejuvenation' protects neurons in mouse models of Parkinson's disease
    C Savio Chan
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nature 447:1081-6. 2007
    Why dopamine-containing neurons of the brain's substantia nigra pars compacta die in Parkinson's disease has been an enduring mystery. Our studies suggest that the unusual reliance of these neurons on L-type Ca(v)1...
  43. ncbi Multiple dopamine functions at different time courses
    Wolfram Schultz
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Annu Rev Neurosci 30:259-88. 2007
    ..behavioral functions that cannot possibly be encoded in great detail by the relatively small number of midbrain dopamine neurons...
  44. pmc Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
    Frank Soldner
    The Whitehead Institute, Cambridge Center, MA 02142, USA
    Cell 136:964-77. 2009
    ..Our results indicate that residual transgene expression in virus-carrying hiPSCs can affect their molecular characteristics and that factor-free hiPSCs therefore represent a more suitable source of cells for modeling of human disease...
  45. pmc Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    Stephan Gehrke
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 466:637-41. 2010
    ..Our results implicate deregulated synthesis of E2F1/DP caused by the miRNA pathway impairment as a key event in LRRK2 pathogenesis and suggest novel miRNA-based therapeutic strategies...
  46. pmc Neuron-type-specific signals for reward and punishment in the ventral tegmental area
    Jeremiah Y Cohen
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 482:85-8. 2012
    b>Dopamine has a central role in motivation and reward...
  47. ncbi Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain
    N D Volkow
    Departments of Medical and Chemistry, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:RC121. 2001
    ..Whereas methylphenidate blocks the dopamine transporter (main mechanism for removal of extracellular dopamine), it is unclear whether at doses used ..
  48. pmc Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:9879-84. 2010
    ..dopaminergic system of LRRK2(-/-) mice appears normal, and numbers of dopaminergic neurons and levels of striatal dopamine are unchanged...
  49. pmc Dopamine signals for reward value and risk: basic and recent data
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    Behav Brain Funct 6:24. 2010
    Previous lesion, electrical self-stimulation and drug addiction studies suggest that the midbrain dopamine systems are parts of the reward system of the brain...
  50. pmc Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
    Vanessa Brochard
    INSERM, UMR S679, Experimental Neurology and Therapeutics, Hopital de la Salpetriere, Paris, France
    J Clin Invest 119:182-92. 2009
    Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system...
  51. pmc Inflammation as a causative factor in the aetiology of Parkinson's disease
    P S Whitton
    1Department of Pharmacology, The School of Pharmacy, London, UK
    Br J Pharmacol 150:963-76. 2007
    ..These factors are examined in this review along with a consideration of the possible use of anti-inflammatory drugs in PD...
  52. ncbi Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
    J D Salamone
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
    Psychopharmacology (Berl) 191:461-82. 2007
    ..Over the last several years, it has become apparent that there are critical problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational ..
  53. ncbi The short-latency dopamine signal: a role in discovering novel actions?
    Peter Redgrave
    Neuroscience Research Unit, Department of Psychology, University of Sheffield, Sheffield, S10 2TP, UK
    Nat Rev Neurosci 7:967-75. 2006
    ....
  54. ncbi Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia
    Shitij Kapur
    Clarke Division of the Centre for Addiction and Mental Health, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 160:13-23. 2003
    ..The objective of this overview is to link the neurobiology (brain), the phenomenological experience (mind), and pharmacological aspects of psychosis-in-schizophrenia into a unitary framework...
  55. pmc Neuroanatomical study of the A11 diencephalospinal pathway in the non-human primate
    Quentin Barraud
    Universite Victor Segalen Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France
    PLoS ONE 5:e13306. 2010
    ..Its anatomical organization, however, remains largely unknown in the non-human primate (NHP). We therefore characterized the anatomy of this pathway in the NHP...
  56. ncbi Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
    M A Ungless
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California 94110, USA
    Nature 411:583-7. 2001
    ..alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid)-receptor-mediated currents at excitatory synapses onto dopamine cells in the ventral tegmental area...
  57. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
    b>Dopamine plays an important role in the etiology of schizophrenia, and D2 class dopamine receptors are the best-established target of antipsychotic drugs...
  58. ncbi Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 304:1-7. 2003
    ..In addition, we also discuss novel approaches to potential therapeutic strategies...
  59. ncbi Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease
    Roshan Cools
    Helen Wills Neuroscience Institute, University of California, 132 Barker Hall, Berkeley, USA
    Neurosci Biobehav Rev 30:1-23. 2006
    ..It is suggested that beneficial or detrimental effects of L-DOPA are observed depending on task demands and basal dopamine levels in distinct parts of the striatum...
  60. pmc Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons
    Reuben Saba
    Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Universitat Heidelberg, and Institut für Neuroanatomie, Universitatsklinikum, Heidelberg, Heidelberg, Germany
    Mol Cell Biol 32:619-32. 2012
    ..Moreover, miR-181a expression was induced by dopamine signaling in primary neurons, as well as by cocaine and amphetamines, in a mouse model of chronic drug treatment...
  61. pmc Dopamine, affordance and active inference
    Karl J Friston
    The Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London, United Kingdom
    PLoS Comput Biol 8:e1002327. 2012
    The role of dopamine in behaviour and decision-making is often cast in terms of reinforcement learning and optimal decision theory...
  62. pmc Opponency revisited: competition and cooperation between dopamine and serotonin
    Y Lan Boureau
    The Courant Institute of Mathematical Sciences, New York University, New York, NY, USA
    Neuropsychopharmacology 36:74-97. 2011
    ..There is ample evidence for the role of dopamine in the appetitive half of this spectrum, but little agreement about the existence, nature, or role of putative ..
  63. pmc Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
    Marta Martinez-Vicente
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, New York, New York 10461, USA
    J Clin Invest 118:777-88. 2008
    ..b>Dopamine-modified alpha-syn, however, is not only poorly degraded by CMA but also blocks degradation of other substrates ..
  64. pmc Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method
    A Breier
    Experimental Therapeutics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:2569-74. 1997
    A major line of evidence that supports the hypothesis of dopamine overactivity in schizophrenia is the psychomimetic potential of agents such as amphetamine that stimulate dopamine outflow...
  65. ncbi Tonic dopamine: opportunity costs and the control of response vigor
    Yael Niv
    Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel
    Psychopharmacology (Berl) 191:507-20. 2007
    b>Dopamine neurotransmission has long been known to exert a powerful influence over the vigor, strength, or rate of responding...
  66. doi Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
    A long-standing version of the dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic transmission at D(2) receptors in the limbic striatum is associated with the illness and that blockade of mesolimbic D(2) ..
  67. doi Changes in cortical dopamine D1 receptor binding associated with cognitive training
    Fiona McNab
    Neuropediatric Unit, Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
    Science 323:800-2. 2009
    Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission...
  68. ncbi Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
    K A Conway
    Center for Neurologic Diseases, Brigham and Women s Hospital, Department of Neurology, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Science 294:1346-9. 2001
    ..All but one of 15 fibril inhibitors were catecholamines related to dopamine. The inhibitory activity of dopamine depended on its oxidative ligation to alpha-synuclein and was selective for ..
  69. ncbi Behavioral theories and the neurophysiology of reward
    Wolfram Schultz
    Department of Anatomy, University of Cambridge, CB2 3DY United Kingdom
    Annu Rev Psychol 57:87-115. 2006
    ..Individual neurons can be studied in the reward systems of the brain, including dopamine neurons, orbitofrontal cortex, and striatum...
  70. ncbi D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA lt j
    Trends Neurosci 30:228-35. 2007
    b>Dopamine shapes a wide variety of psychomotor functions. This is mainly accomplished by modulating cortical and thalamic glutamatergic signals impinging upon principal medium spiny neurons (MSNs) of the striatum...
  71. ncbi Coupled temporal memories in Parkinson's disease: a dopamine-related dysfunction
    C Malapani
    Columbia University Department of Psychology New York NY 10027, USA
    J Cogn Neurosci 10:316-31. 1998
    ..We examined PD patients when brain dopamine (DA) transmission was impaired (OFF state) and when DA transmission was reestablished, at the time of maximal ..
  72. ncbi Dopamine neuron systems in the brain: an update
    Anders Bjorklund
    Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund SE 22184, Sweden
    Trends Neurosci 30:194-202. 2007
    ..of highly sensitive tract-tracing techniques, has provided a progressively more detailed picture, making the dopamine system one of the best known, and most completely mapped, neurotransmitter systems in the brain...
  73. pmc Layered reward signalling through octopamine and dopamine in Drosophila
    Christopher J Burke
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 492:433-7. 2012
    b>Dopamine is synonymous with reward and motivation in mammals. However, only recently has dopamine been linked to motivated behaviour and rewarding reinforcement in fruitflies...
  74. ncbi DARPP-32: an integrator of neurotransmission
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Annu Rev Pharmacol Toxicol 44:269-96. 2004
    b>Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified initially as a major target for dopamine and protein kinase A (PKA) in striatum...
  75. ncbi Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
    Jong Hoon Kim
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 418:50-6. 2002
    ..disease is a widespread condition caused by the loss of midbrain neurons that synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify the course of the disease, but they are an inadequate source of ..
  76. pmc Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    H L Melrose
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:503-17. 2010
    ..In vivo analysis of the dopaminergic system revealed abnormal dopamine neurotransmission in both hWT and G2019S transgenic mice evidenced by a decrease in extra-cellular dopamine ..
  77. ncbi The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes
    Robert M Bilder
    Department of Psychiatry, David Geffen School of Medicine and Psychology, UCLA Neuropsychiatric Institute, University of California at Los Angeles, Los Angeles, CA, USA
    Neuropsychopharmacology 29:1943-61. 2004
    ..that some of the complex effects of this polymorphism be understood from the perspective of the tonic-phasic dopamine (DA) hypothesis...
  78. ncbi Genetically determined differences in learning from errors
    Tilmann A Klein
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Science 318:1642-5. 2007
    The role of dopamine in monitoring negative action outcomes and feedback-based learning was tested in a neuroimaging study in humans grouped according to the dopamine D2 receptor gene polymorphism DRD2-TAQ-IA...
  79. ncbi Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
    R B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
    Synapse 39:32-41. 2001
    A large body of evidence supports the hypothesis that mesolimbic dopamine (DA) mediates, in animal models, the reinforcing effects of central nervous system stimulants such as cocaine and amphetamine...
  80. pmc Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
    Xianting Li
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 30:1788-97. 2010
    ..Transgenic LRRK2-Wt mice had elevated striatal dopamine (DA) release with unaltered DA uptake or tissue content...
  81. pmc Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum
    Emmanuel Valjent
    Institut National de la Santé et de la Recherche Médicale and Université Pierre et Marie Curie U536, Signal Transduction and Plasticity in the Nervous System, Institut du Fer a Moulin, 17 Rue du Fer a Moulin, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:491-6. 2005
    Many drugs of abuse exert their addictive effects by increasing extracellular dopamine in the nucleus accumbens, where they likely alter the plasticity of corticostriatal glutamatergic transmission...
  82. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
    ..b>Dopamine projections ascending from the midbrain provide important modulatory input to these striatal subregions...
  83. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
    ..in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine (DA) function before drug exposure...
  84. doi Brain serotonin and dopamine transporter bindings in adults with high-functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Arch Gen Psychiatry 67:59-68. 2010
    ..Although its neurobiological underpinnings are postulated to lie in abnormalities of the serotoninergic and dopaminergic systems, the details remain unknown...
  85. doi A subset of dopamine neurons signals reward for odour memory in Drosophila
    Chang Liu
    Max Planck Institut fur Neurobiologie, Martinsried 82152, Germany
    Nature 488:512-6. 2012
    ..Here we show that a group of dopamine neurons in the protocerebral anterior medial (PAM) cluster signals sugar reward by transient activation and ..
  86. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    ..Using viral-mediated, mesolimbic dopamine pathway-specific knockdown of brain-derived neurotrophic factor (BDNF), we showed that BDNF is required for the ..
  87. ncbi Neuromodulation of the locomotor network by dopamine in the isolated spinal cord of newborn rat
    Grégory Barrière
    CNRS UMR 5543, Physiologie et Physiopathologie de la Signalisation Cellulaire, Universite Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Eur J Neurosci 19:1325-35. 2004
    We have analysed the action of the neuromodulatory catecholamine, dopamine (DA), on the lumbar locomotor network using an isolated in vitro newborn rat spinal cord preparation...
  88. ncbi Coincident but distinct messages of midbrain dopamine and striatal tonically active neurons
    Genela Morris
    Department of Physiology, Hadassah Medical School, The Interdisciplinary Center for Neural Computation, The Hebrew University, Jerusalem 91120, Israel
    Neuron 43:133-43. 2004
    Midbrain dopamine and striatal tonically active neurons (TANs, presumed acetylcholine interneurons) signal behavioral significance of environmental events...
  89. pmc Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons
    Martin Lundblad
    Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, Lund 221 84, Sweden
    Proc Natl Acad Sci U S A 109:3213-9. 2012
    We used in vivo amperometry to monitor changes in synaptic dopamine (DA) release in the striatum induced by overexpression of human wild-type α-synuclein in nigral DA neurons, induced by injection of an adeno-associated virus type 6 (..
  90. pmc Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing
    Roger Cachope
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cell Rep 2:33-41. 2012
    b>Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, and its release dynamics have traditionally been linked to changes in midbrain dopamine neuron activity...
  91. pmc How dopamine enhances an optimism bias in humans
    Tali Sharot
    Department of Cognitive, Perceptual and Brain Sciences, University College London, 26 Bedford Way, London WC1H 0AP, UK
    Curr Biol 22:1477-81. 2012
    ..These findings provide the first evidence that the neuromodulator dopamine impacts on belief formation by reducing negative expectations regarding the future.
  92. doi Dopamine and adaptive memory
    Daphna Shohamy
    Department of Psychology, Columbia University, New York, NY 10025, USA
    Trends Cogn Sci 14:464-72. 2010
    ..Emerging findings indicate that the neurotransmitter dopamine, which signals motivationally important events, also modulates the hippocampus, a crucial brain system for long-..
  93. doi Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson's disease
    Shen Yang Lim
    Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    J Clin Neurosci 16:1148-52. 2009
    Data regarding the effect of deep brain stimulation (DBS) surgery on the dopamine dysregulation syndrome (DDS), impulse control disorders (ICDs) and punding in Parkinson's disease (PD) are limited...
  94. ncbi The role of dopamine in the pathophysiology of depression
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 64:327-37. 2007
  95. pmc Reward, dopamine and the control of food intake: implications for obesity
    Nora D Volkow
    National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cogn Sci 15:37-46. 2011
    ..that regulate energy balance (homeostatic processes) through the hypothalamus also modulate the activity of dopamine cells and their projections into regions involved in the rewarding processes underlying food intake...
  96. ncbi Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
    J D Jentsch
    Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208001, New Haven, CT 06520 8001, USA
    Psychopharmacology (Berl) 146:373-90. 1999
    ..These phenomena have been linked with dopamine function within the ventral striatum and amygdala and have been described specifically in terms of motivational ..
  97. ncbi What is reinforced by phasic dopamine signals?
    Peter Redgrave
    Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK
    Brain Res Rev 58:322-39. 2008
    ..A strong line of supporting evidence comes from the recording of dopamine (DA) neurones in behaving monkeys...
  98. ncbi DARPP-32: regulator of the efficacy of dopaminergic neurotransmission
    A A Fienberg
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Science 281:838-42. 1998
    Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is ..
  99. ncbi Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models
    Anatol C Kreitzer
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 445:643-7. 2007
    ..indirect-pathway MSNs selectively express endocannabinoid-mediated long-term depression (eCB-LTD), which requires dopamine D2 receptor activation...
  100. pmc R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
    Youren Tong
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:14622-7. 2009
    ..normal and exhibit no dopaminergic (DA) neurodegeneration or alterations in steady-state levels of striatal dopamine up to 2 years of age...
  101. pmc Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
    E Stice
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    Science 322:449-52. 2008
    The dorsal striatum plays a role in consummatory food reward, and striatal dopamine receptors are reduced in obese individuals, relative to lean individuals, which suggests that the striatum and dopaminergic signaling in the striatum may ..

Research Grants76

  1. K OPIOIDS AND DOPAMINE--MECHANISMS OF STIMULANT ABUSE
    Sari Izenwasser; Fiscal Year: 2001
    ..These psychostimulant drugs produce their reinforcing effects via interactions with the dopamine transporter, cocaine by inhibiting dopamine uptake (the inward flow of dopamine into the neuron), and ..
  2. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..While many brain-based processes are thought to be disordered in schizophrenia, the neurotransmitter dopamine has been most strongly implicated...
  3. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..The core working hypothesis is that response and non-response are regulated by the coherence level of the dopamine D2 receptor (Drd2) gene network. The research plan contains four specific aims...
  4. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
    ..R01 grant submissions during the independent phase may focus on other nAChR subunits and signaling mechanisms (dopamine, serotonin, enkephalin, etc...
  5. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..is characterized by progressive loss of neurons that control movement via the action of the neurotransmitter dopamine. The neurons are lost through deterioration of their antioxidant defense mechanisms and the adverse effects of ..
  6. Sex Steroid Hormone Regulation of Drug Reinforcement
    Diane Lebesgue; Fiscal Year: 2012
    ..observation that the newly discovered estrogen receptor GPR30, which is a GPCR, is specifically expressed in dopamine cells of the ventral tegmental area (VTA) that project to the nucleus accumbens prompted me to examine the ..
  7. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..in mice whereas half-lives of 1-2 min are the norm for chemically similar biogenic amines such as seratonin and dopamine. In addition, we have found that 2-week daily dosing of T1AM with doses approaching the 5g/kg range lead to ..
  8. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..use transgenic mice (designated Dbh- EGFP) that express EGFP under the control of the regulatory elements of the dopamine 2-hydroxylase (Dbh) gene - a marker of noradrenergic neurons...
  9. Exome re-sequencing candidate loci for familial essential tremor
    Barry E Kosofsky; Fiscal Year: 2012
    ..Polymorphic ETM1 loci in 16 Icelandic families and a variant in the dopamine receptor D3 gene in 23 French families are associated with an ET phenotype...
  10. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..This region contains the dendrites of dopamine neurons and is involved in the regulation of locomotor activity...
  11. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..Unlike first generation antipsychotics (FGAs), SGAs bind multiple receptors including dopamine, serotonin, histamine and alpha-adrenergic receptors and could therefore affect multiple tissues and organ ..
  12. Therapeutic Approaches for Extinction of Conditioned Drug Reward
    Gary B Kaplan; Fiscal Year: 2013
    ..COR is hypothesized to involve increases in brain derived neurotrophic factor (BDNF) in mesocorticolimbic dopamine neurons such as prefrontal cortex (PFC) and basolateral amygdala (BLA)...
  13. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben-Jonathan; Fiscal Year: 2013
    ..We discovered expression of dopamine receptors (DAR) in breast tissue, adipocytes and BCC...
  14. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..applicant): Project summary/abstract Parkinson's disease (PD) is the prototypic degenerative disease of the dopamine (DA) neuronal system...
  15. Cell stress, development, and stimulant-induced behavior: Regulation by GSK3
    Marjelo A Mines; Fiscal Year: 2012
    ..Specific Aim 2 will test in mouse brain the developmental changes in GSK3 and its regulation by stimulants. Dopamine-mediated hyperactivity induced by amphetamine treatment is completely blocked by GSK3 inhibitors, signifying that ..
  16. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013
    ..In 2009 I joined the laboratory of Dr. Robert Greene, a recognized leader in the field of dopamine mediated alterations in hippocampal circuit and functional output, to focus my attention on dopamine dependent ..
  17. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..GluR2 subunit and the metabotropic group I glutamate receptor mGluR1 or 5 subunit, or the dopamine D1 receptor may contribute to NMDA neurotransmission deficiency...
  18. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..in mice whereas half-lives of 1-2 min are the norm for chemically similar biogenic amines such as serotonin and dopamine. In addition, the volume of distribution of T1AM is very high suggesting that T1AM distributes widely from ..
  19. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..2,3 dioxygenase including kynurenine, quinolinic acid and kynurenic acid, which has been shown to reduce dopamine release in the basal ganglia...
  20. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..neuroimaging studies involving pharmacological challenge with amphetamine and methylphenidate support the role of dopamine (DA) release in reward-related ventral striatal (VS) functioning...
  21. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2013
    ..relevant odors may act as natural rewards, the routes through which odors are conveyed to the mesolimbic dopamine system that mediates reinforcement have yet to be identified...
  22. Testing the efficacy of PGC-1alpha as a therapeutic target for Parkinson's diseas
    HANS BUELER; Fiscal Year: 2010
    Parkinson's disease (PD), the most frequent movement disorder, is caused by the progressive loss of the dopamine neurons within the substantia nigra pars compacta (SNc) and the associated deficiency of the neurotransmitter dopamine ..
  23. Early social stress, novelty seeking, and impulsive behavior
    David M Lyons; Fiscal Year: 2013
    ..preliminary evidence further suggests that early exposure to social stress induces long-lasting downregulation of dopamine D2 receptor (DRD2) gene expression in ventral but not dorsal striatum...
  24. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    ..Current animal models include 6-hydroxydopamine-lesioned rodents, iron deficiency mice, and dopamine receptor 3 knockout mice...
  25. Dopamine D1 Receptor in mouse models of primary dystonia
    Laurie J Ozelius; Fiscal Year: 2013
    ..G?olf is a G protein that couples striatal dopamine D1 (D1R) and adenosine A2a (A2AR) receptors to adenylyl cyclase V...
  26. Glial-neuronal interactions underlying the molecular feedback between HIV viral p
    Sulie L Chang; Fiscal Year: 2013
    ..We have also demonstrated that there is elevated dopamine D1 receptor (D1R) expression in the prefrontal cortex of HIV-1Tg rats, and that these animals have greater METH-..
  27. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..of voluntary movement and habitual behavior, and is also under the control of a chemical messenger known as dopamine. A key protein in these signaling pathways in striatum is the G-protein gamma type 7 subunit...
  28. Glucocorticoids, Stress and Blood Pressure Regulation
    Deborah A Scheuer; Fiscal Year: 2013
    ..The synthetic dopamine-ss-hydroxylase promoter PRSx8 will be used to drive expression of the transgenes selectively in catecholaminergic ..
  29. PERIPHERAL AND CENTRAL INTERACTIONS IN ENERGY BALANCE
    Barbara B Kahn; Fiscal Year: 2010
    ..expenditure through effects on sympathetic activity and resting energy expenditure and through effects on the dopamine system locomotor activity...
  30. Role in Myopia Development of Retinal Pigment Epithelium - A New Therapeutic Targ
    Yan Zhang; Fiscal Year: 2013
    ..role of RPE-derived bone morphogenetic proteins (BMPs) in eye growth regulation;(2) to investigate the effects of dopamine (DA) on RPE-BMP expression and secretion;(3) to investigate over-expression of BMPs in RPE as a potential gene ..
  31. Therapeutic Strategies for Neonatal Hypoxic-Ischemic Encephalopathy
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2012
    ..Striatonigral neurons are enriched with dopamine D1 receptors, and striatopallidal neurons are enriched with adenosine A2A receptors, both of which act via PKA ..
  32. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..metabolism (HFE, transferrin, DMT-1), cholesterol metabolism (apolipoprotein E), neurotransmitter metabolism (dopamine transporter, dopamine D4 receptor, norepinephrine transporter, monoamine oxidase, catechol O-methyltransferase, ..
  33. Neuronal mRNA PET Imaging
    Eric Wickstrom; Fiscal Year: 2010
    ..Cocaine, which binds to the dopamine receptor 2 (D2R), is the most widely abused drug...
  34. DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAIN
    Ralph A Nixon; Fiscal Year: 2013
    ..Based on new findings that NFM and the D1 dopamine receptor (D1R) interact functionally to modulate D1R -mediated behaviors in vivo, we will test the hypothesis ..
  35. Presynaptic Mechanisms Regulating the Dopamine Transporter
    JAMES A HARDAWAY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The catecholamine neurotransmitter dopamine (DA) functions in neural circuits across phylogeny to modulate both simple and complex behaviors...
  36. Inducible recombination and gene expression in specific neurotransmitter systems
    Steven A Thomas; Fiscal Year: 2012
    ..genes that uniquely define these neurotransmitter systems will be utilized: for the adrenergic system - dopamine 2- hydroxylase, for the dopaminergic system - dopamine transporter, for the serotonergic system - tryptophan ..
  37. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
    ..EAAT3-mediated cysteine transport is stimulated by dopamine, involving the D4 dopamine receptor, which has been linked to the frequency of drug abuse...
  38. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2012
    ..mechanism for this sex difference in dopaminergic function is sex-specific trophic actions which maintain dopamine neurons...
  39. In utero programming of the dopamine system: behavior, neuroanatomy &epigenetics
    Teresa M Reyes; Fiscal Year: 2013
    ..These behaviors involve dopamine (DA), and in both animal models of and human patients with ADHD, alterations in DA signaling have been documented...
  40. Novel therapy for monoamine neurotransmitter deficiency in PKU
    Cary O Harding; Fiscal Year: 2013
    ..Deficiency of the monoamine neurotransmitters, dopamine and serotonin, in brain has been implicated as a probable proximal cause of neurobehavioral difficulties in PKU...
  41. Pharmacology of Risperidone Effects on Bone Remodeling and Energy Metabolism
    Karen L Houseknecht; Fiscal Year: 2013
    ..pharmacology of SGAs is complex: they potently antagonize multiple G protein coupled receptors (GPCRs) including dopamine, serotonin, alpha- adrenergic and histamine receptors...
  42. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..Alterations of serotonin (5-HT) and dopamine (DA) activity may contribute to extremes of appetitive behaviors in anorexia nervosa (AN) and bulimia nervosa (BN)..
  43. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..b>Dopamine D2/D3 receptor expression have recently been demonstrated on rodent and human [unreadable]-cells using isolated ..
  44. Cannabinoid regulation of glycogen synthase kinase-3
    Cecilia J Hillard; Fiscal Year: 2013
    ..These preliminary data, together with data in the literature regarding D2 dopamine receptor signaling, were used to formulate the hypothesis that prolonged CB1R activation results in recruitment ..
  45. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..Nevertheless, the mechanisms involved have yet to be established. One possibility includes cytokine effects on dopamine (DA) metabolism in the basal ganglia...
  46. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    ..NSS include the transporters for dopamine, serotonin and norepinephrine-targets for amphetamine, cocaine, and antidepressant drugs-as well as the ..
  47. Protein Phosphatase Regulation of the Principal Renal Sodium Transporter NHE3
    Ion Alexandru Bobulescu; Fiscal Year: 2013
    ..of the principal renal sodium transporter NHE3, with special emphasis on the regulation of NHE3 by intra-renal dopamine. If the proposed hypotheses are correct, PP2A will be established as a major regulator of intrarenal dopamine ..
  48. NHERF-1 and dopamine-mediated regulation of renal phosphate transport.
    Edward J Weinman; Fiscal Year: 2013
    ..phosphorylation of NHERF-1 is regulated by other hormones, we propose studies to examine the mechanism by which dopamine inhibits renal phosphate transport...
  49. Neuroplasticity with alcohol dependence
    Scott C Steffensen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The prevailing view is that enhancement of dopamine transmission in the mesocorticolimbic system underlies the rewarding properties of alcohol...
  50. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    Virginia M Pickel; Fiscal Year: 2012
    ..sites include the prefrontal cortex (PFC), the nucleus accumbens (Acb) and other forebrain regions that receive dopamine input from mesolimbic dopaminergic neurons within the ventral tegmental area (VTA)...
  51. ALCOHOL AND HYPERPROLACTINEMIA
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    ..Recent studies in animals have identified a role for dopamine receptor 2 (D2R) in mediating the inhibitory control of hypothalamic dopamine on prolactin-secreting lactotropes ..
  52. Understanding the Role of COMT Variants in Sensorimotor Gating
    XIANJIN ZHOU; Fiscal Year: 2010
    ..This decrease in enzymatic activity can reduce dopamine clearance in the cortex and enhance dopamine signaling...
  53. Diet, Insulin, Dopamine, and Reward.
    Margaret E Rice; Fiscal Year: 2013
    ..preliminary data obtained using in vitro voltammetry show that nM levels of insulin increase evoked extracellular dopamine (DA) concentration ([DA]o) in caudate/putamen (CPu) and nucleus accumbens (NAc)...
  54. Sex and Stress Mechanisms of Vulnerability to Addiction
    Rajita Sinha; Fiscal Year: 2011
    ..and cocaine converge within the ventral tegmental area (VTA) having similar, and potentially additive, effects on dopamine (DA) signaling. Ultimately, this leads to altered signal transduction within cortico-limbic-striatal regions...
  55. How do Amine Neurons Work?
    Edward A Kravitz; Fiscal Year: 2013
    ..Included are motor system disorders like Parkinson's Disease in which subsets of the dopamine neurons selectively die, and psychiatric disorders including mood disorders, schizophrenia, attention-deficit ..
  56. A Phase II Trial of Levodopa in Angelman Syndrome
    Wen Hann Tan; Fiscal Year: 2013
    ..Levodopa (LD) is a prodrug that "delivers" dopamine to the brain...
  57. Analysis of PTH and Dopamine Receptor Signaling in Proximal Tubules
    Eleanor D Lederer; Fiscal Year: 2013
    ..Thus understanding how the kidney regulates phosphate homeostasis has significant relevance to the health of Veterans of all ages. ..
  58. Anabolic-androgenic steroids enhance motivation
    Ruth I Wood; Fiscal Year: 2013
    ..We will determine if testosterone is a permissive signal to enhance dopamine activity in the nucleus accumbens in response to sexual stimuli (Aim 2A)...
  59. MOLECULAR NEUROBIOLOGY OF DRUG ADDICTION
    Eric J Nestler; Fiscal Year: 2013
    ..of a productive and collaborative effort among several laboratories to study the role of CREB in the mesolimbic dopamine reward circuit, comprised of dopamine neurons in the ventral tegmental area (VTA) and their projection regions, ..
  60. Persistent Attenuation of Cocaine-Reinforced Behavior
    KENNETH W GRASING; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Background Reinforcing effects of cocaine arise through release of dopamine (DA) in the nucleus accumbens by neurons that project from the ventral tegmental area (VTA)...
  61. Neural Actions of Toluene
    John J Woodward; Fiscal Year: 2013
    ..Whole-cell patch-clamp electrophysiology will be used to study the effects of toluene on dopamine neurons of the ventral tegmental area (VTA), medium spiny neurons of the nucleus accumbens (NAcc) and deep-layer ..
  62. Pharmacological Management of Delirium
    Malaz Boustani; Fiscal Year: 2013
    ..Disturbances in several neurotransmitters, such as acetylcholine, dopamine, glutamate, serotonin, norepinephrine, and gamma-aminobutyric acid (GABA), have been suggested to be involved in ..
  63. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher L Cunningham; Fiscal Year: 2012
    ..Neurotransmitters of interest include: dopamine, gamma-aminobutyric acid, glutamate, serotonin, and opioid peptides...
  64. Multigenerational Epigenetic Effects of Cannabis Exposure
    Yasmin L Hurd; Fiscal Year: 2013
    ..male and female F1 offspring show decreased striatal expression of genes that encode several components of the dopamine, opioid and glutamate neurotransmitter systems...
  65. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..Two patients died of causes unrelated to the transplant. Both showed substantial survival of transplanted dopamine neurons as assessed by counts of hydroxylase positive neurons in the striatum...
  66. AUTORECEPTOR REGULATION OF DOPAMINE RELEASE
    Greg Gerhardt; Fiscal Year: 1991
    ..The chronic intake of amphetamine, a dopamine releasing drug, can produce clinical symptoms similar to paranoid schizophrenia, whereas the drugs that are used ..
  67. Molecular biology of mesocortical and mesoaccumbens dopamine neurons
    JEFFREY EELLS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Aberrant dopamine neurotransmission has been implicated in schizophrenia with elevated mesoaccumbens (or subcortical) dopamine neurotransmission contributing to positive symptoms of schizophrenia (..
  68. Subtype Specific Agonists for D1-D5 Dopamine Receptors
    William Goddard; Fiscal Year: 2007
    ..It is implicated in such diseases as schizophrenia (excess of dopamine), Parkinson's disease (lack of dopamine), drug abuse, and alcoholism, all of which involve imbalances in the ..
  69. Regulation and function of Nurr1 in adult nigrostriatal dopamine neurons
    JEFFREY EELLS; Fiscal Year: 2009
    ..disease is a common neurological disorder, the symptoms of which are caused primarily by a loss of dopamine neurons in the substantia nigra and reduced dopamine in the striatum...
  70. DOPAMINE IN NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY
    Francis Filloux; Fiscal Year: 1992
    The hypothesis of this proposal for a CIA is that excessive dopamine release in the neostriatum may contribute to the cerebral damage incurred in neonatal hypoxic-ischemic encephalopathy...
  71. Amphetamine Acts as a Molecular Stent in the Dopamine Transporter
    Louis J De Felice; Fiscal Year: 2010
    ..Amphetamine acts as a Molecular Stent in the Dopamine Transporter By introducing the term 'molecular stent'in connection with amphetamine and the dopamine ..
  72. SIGNALING MECHANISMS IN DOPAMINE RECEPTOR SYNERGISM
    Yuan Luo; Fiscal Year: 2007
    b>Dopamine plays important roles in the neural regulation of movement, motivation, memory, cognition, mood, and neuroendocrine integration...
  73. D1-like dopamine receptors in learning and behavior
    JULIE MUSTARD; Fiscal Year: 2005
    b>Dopamine has been implicated in many roles in behavioral and cognitive functions. For example, changes in dopamine levels regulate important components of reward pathways in the brain...
  74. Functional characterization of D3 dopamine receptor in Drd3-EGFP transgenic mice
    Eldo V Kuzhikandathil; Fiscal Year: 2010
    DESCRIPTION (provided by the applicant): The neurotransmitter dopamine activates two major classes of dopamine receptors. These include the D1-like (D1 and D5) and the D2-like dopamine receptors (D2, D3 and D4)...
  75. Dopaminergic modulation of cost/benefit decision making during aging
    Paul Phillips; Fiscal Year: 2009
    ..b>Dopamine plays an important role in dealing with these costs: antagonism of dopamine is sufficient to lower the physical ..
  76. PURINE-DOPAMINE RELATIONSHIPS IN LESCH-NYHAN DISEASE
    HYDER JINNAH; Fiscal Year: 2001
    ..studies of LND have revealed marked increases in de novo purine synthesis as well as depletion of basal ganglia dopamine. However, the relationship between these two abnormalities and the mechanisms by which HPRT deficiency causes ..