dobutamine

Summary

Summary: A beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.

Top Publications

  1. ncbi Experimental validation of circumferential, longitudinal, and radial 2-dimensional strain during dobutamine stress echocardiography in ischemic conditions
    Patricia Reant
    INSERM U828 and IFR4, University of Bordeaux 2, Bordeaux, France
    J Am Coll Cardiol 51:149-57. 2008
  2. ncbi Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease
    Philip A Read
    Department of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Heart 98:408-13. 2012
  3. ncbi Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics
    Jean Luc Monin
    Department of Cardiology, Henri Mondor Hospital, 51 avenue de Lattre de Tassigny, 94010 Creteil, France
    Circulation 108:319-24. 2003
  4. ncbi Impact of individual and cumulative coronary risk factors on coronary flow reserve assessed by dobutamine stress echocardiography
    Saeed A L Ahmari
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 101:1694-9. 2008
  5. pmc Low-dose dobutamine tissue-tagged magnetic resonance imaging with 3-dimensional strain analysis allows assessment of myocardial viability in patients with ischemic cardiomyopathy
    Douglas Bree
    Department of Cardiovascular Medicine, Washington University, St Louis, MO, USA
    Circulation 114:I33-6. 2006
  6. ncbi Lowered B-type natriuretic peptide in response to levosimendan or dobutamine treatment is associated with improved survival in patients with severe acutely decompensated heart failure
    Alain Cohen-Solal
    Hospital Lariboisiere, Assistance Publique Hopitaux de Paris, and Faculté de Médecine Denis Diderot, INSERM U 942, Paris, France
    J Am Coll Cardiol 53:2343-8. 2009
  7. ncbi Quantitative myocardial perfusion and coronary reserve in rats with 13N-ammonia and small animal PET: impact of anesthesia and pharmacologic stress agents
    Etienne Croteau
    Departement de Medecine Nucleaire et Radiobiologie, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Nucl Med 45:1924-30. 2004
  8. ncbi Safety of dobutamine-atropine stress echocardiography: A prospective experience of 4,033 consecutive studies
    W Mathias
    Echocardiography Laboratories of Paulista School of Medicine UNIFESP and Exata Diagnostics, Sao Paulo, Brazil
    J Am Soc Echocardiogr 12:785-91. 1999
  9. ncbi Dobutamine improves liver function after hemorrhagic shock through induction of heme oxygenase-1
    Alexander Raddatz
    Klinik für Anaesthesiologie und Intensivmedizin, Universitat des Saarlandes, D 66421 Homburg Saar, Germany
    Am J Respir Crit Care Med 174:198-207. 2006
  10. ncbi Incremental value of strain rate imaging to wall motion analysis for prediction of outcome in patients undergoing dobutamine stress echocardiography
    Charlotte Bjork Ingul
    University of Queensland, Brisbane, Australia
    Circulation 115:1252-9. 2007

Detail Information

Publications326 found, 100 shown here

  1. ncbi Experimental validation of circumferential, longitudinal, and radial 2-dimensional strain during dobutamine stress echocardiography in ischemic conditions
    Patricia Reant
    INSERM U828 and IFR4, University of Bordeaux 2, Bordeaux, France
    J Am Coll Cardiol 51:149-57. 2008
    The aim of this study was to assess and validate 2-dimensional (2D) strain for the detection of ischemia during dobutamine stress echocardiography (DSE).
  2. ncbi Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease
    Philip A Read
    Department of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Heart 98:408-13. 2012
    ..Its pharmacological properties as a cardioprotective agent are attractive because it has a short half-life and there is minimal risk of hypoglycaemia...
  3. ncbi Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics
    Jean Luc Monin
    Department of Cardiology, Henri Mondor Hospital, 51 avenue de Lattre de Tassigny, 94010 Creteil, France
    Circulation 108:319-24. 2003
    The prognostic value of dobutamine stress hemodynamic data in the setting of low-gradient aortic stenosis has been addressed in small, single-center studies...
  4. ncbi Impact of individual and cumulative coronary risk factors on coronary flow reserve assessed by dobutamine stress echocardiography
    Saeed A L Ahmari
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 101:1694-9. 2008
    ..Most studies that have evaluated microcirculation rely on invasive measurement tools. We used dobutamine stress echocardiography, a validated method to measure coronary flow velocity (CFV) and coronary flow reserve (..
  5. pmc Low-dose dobutamine tissue-tagged magnetic resonance imaging with 3-dimensional strain analysis allows assessment of myocardial viability in patients with ischemic cardiomyopathy
    Douglas Bree
    Department of Cardiovascular Medicine, Washington University, St Louis, MO, USA
    Circulation 114:I33-6. 2006
    ..We assessed the hypothesis that 3D strain determination at rest and with low-dose dobutamine would discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy (ICM).
  6. ncbi Lowered B-type natriuretic peptide in response to levosimendan or dobutamine treatment is associated with improved survival in patients with severe acutely decompensated heart failure
    Alain Cohen-Solal
    Hospital Lariboisiere, Assistance Publique Hopitaux de Paris, and Faculté de Médecine Denis Diderot, INSERM U 942, Paris, France
    J Am Coll Cardiol 53:2343-8. 2009
    ....
  7. ncbi Quantitative myocardial perfusion and coronary reserve in rats with 13N-ammonia and small animal PET: impact of anesthesia and pharmacologic stress agents
    Etienne Croteau
    Departement de Medecine Nucleaire et Radiobiologie, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Nucl Med 45:1924-30. 2004
    ..The purpose of this study was to evaluate the effects of 2 anesthetic agents on myocardial perfusion and coronary reserve in rats under resting and stress conditions with small animal PET...
  8. ncbi Safety of dobutamine-atropine stress echocardiography: A prospective experience of 4,033 consecutive studies
    W Mathias
    Echocardiography Laboratories of Paulista School of Medicine UNIFESP and Exata Diagnostics, Sao Paulo, Brazil
    J Am Soc Echocardiogr 12:785-91. 1999
    b>Dobutamine-atropine stress echocardiography (DASE) is an established method and has been shown to be accurate for the detection of coronary artery disease...
  9. ncbi Dobutamine improves liver function after hemorrhagic shock through induction of heme oxygenase-1
    Alexander Raddatz
    Klinik für Anaesthesiologie und Intensivmedizin, Universitat des Saarlandes, D 66421 Homburg Saar, Germany
    Am J Respir Crit Care Med 174:198-207. 2006
    Induction of heme oxygenase-1 (HO-1) protects the liver against reperfusion injury after hemorrhagic shock. Previous data suggest that the beta(1)-adrenoceptor agonist dobutamine induces HO-1 in hepatocytes.
  10. ncbi Incremental value of strain rate imaging to wall motion analysis for prediction of outcome in patients undergoing dobutamine stress echocardiography
    Charlotte Bjork Ingul
    University of Queensland, Brisbane, Australia
    Circulation 115:1252-9. 2007
    Wall motion score at dobutamine stress echocardiography is an independent predictor of mortality. We sought to determine whether quantification of DSE by strain rate imaging was incremental to wall motion score for predicting outcome.
  11. ncbi The additive prognostic value of end-systolic pressure-volume relation in patients with diabetes mellitus having negative dobutamine stress echocardiography by wall motion criteria
    L Cortigiani
    Division of Cardiology, Campo di Marte Hospital, Lucca, Italy
    Heart 95:1429-35. 2009
    ..The aim of the study was to assess the prognostic value of ESPVR in patients with diabetes mellitus having negative dobutamine stress echocardiography by wall motion criteria.
  12. ncbi Pulmonary vascular resistance, collateral flow, and ventricular function in patients with a Fontan circulation at rest and during dobutamine stress
    Boris Schmitt
    Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Berlin and The Charité, Medical University Berlin, Berlin, Germany
    Circ Cardiovasc Imaging 3:623-31. 2010
    ..The role, interplay, and relative importance of the multifactorial hemodynamic and myocardial mechanisms causing dysfunction of the Fontan circulation remain incompletely understood...
  13. pmc Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension
    C D Vizza
    Department of Cardiovascular and Respiratory Sciences, University of Rome 'La Sapienza, Rome, Italy
    Crit Care 5:355-61. 2001
    INTRODUCTION: The use of low-dose dobutamine to maintain hemodynamic stability in pulmonary hypertension may have a detrimental effect on gas exchange...
  14. pmc The effects of dobutamine and dopamine on intrapulmonary shunt and gas exchange in healthy humans
    Tracey L Bryan
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    J Appl Physiol (1985) 113:541-8. 2012
    ..b>Dobutamine and dopamine are inotropes commonly used to augment cardiac output; however, both can increase venous admixture/..
  15. ncbi Effect of nesiritide versus dobutamine on short-term outcomes in the treatment of patients with acutely decompensated heart failure
    Marc A Silver
    Heart Failure Institute, Advocate Christ Medical Center, Oak Lawn, Illinois 60453, USA
    J Am Coll Cardiol 39:798-803. 2002
    ..was designed to determine whether nesiritide, administered for acute decompensated congestive heart failure (CHF), affects healthcare costs by hospital length of stay (LOS), readmissions and short-term mortality, compared to dobutamine.
  16. ncbi Relation of myocardial histomorphometric features and left ventricular contractile reserve assessed by high-dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy
    Petar Otasevic
    Dr Aleksandar D Popovic Cardiovascular Research Center, Dedinje Cardiovascular Institute, Belgrade University Medical School, Milana Tepica 1, 11040 Belgrade, Serbia and Montenegro, Yugoslavia
    Eur J Heart Fail 7:49-56. 2005
    This study was designed to determine the relationship between histomorphometric features and contractile reserve assessed by high-dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy.
  17. ncbi Comparison of two-dimensional speckle and tissue Doppler strain measurement during dobutamine stress echocardiography: an angiographic correlation
    Lizelle Hanekom
    Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Eur Heart J 28:1765-72. 2007
    ..We compared their feasibility and accuracy in 150 patients undergoing dobutamine stress echocardiography (DSE) and coronary angiography.
  18. ncbi Influence of preload and afterload on stroke volume response to low-dose dobutamine stress in patients with non-ischemic heart failure: a cardiac MR study
    Alessandro Pingitore
    CNR Institute of Clinical Physiology, Pisa, Italy
    Int J Cardiol 166:475-81. 2013
    Lack of increase in left ventricular (LV) stroke volume (SV) during low-dose dobutamine stress (LDD) is attributed to exhausted cardiac contractile reserve in failing heart...
  19. ncbi Validation of the myocardial performance index by echocardiography in mice: a noninvasive measure of left ventricular function
    Craig S Broberg
    Divisions of Cardiology, Oregon Health and Science University, Portland, Oregon 97221, USA
    J Am Soc Echocardiogr 16:814-23. 2003
    ..The myocardial performance index (MPI) is a Doppler-based measure of left ventricular (LV) function. It is noninvasive, independent of LV shape, and does not require dimensional measurements. However, it has never been validated in mice...
  20. ncbi Development of cardiovascular disease due to renal insufficiency in male sheep following fetal unilateral nephrectomy
    Reetu R Singh
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    J Hypertens 27:386-96. 2009
    ..Renal insufficiency is associated with the development of cardiovascular disease...
  21. ncbi Increased systemic oxygen consumption offsets improved oxygen delivery during dobutamine infusion in newborn lambs
    D J Penny
    Centre for Heart and Chest Research, Monash University Department of Medicine, Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, Victoria, Australia, 3168
    Intensive Care Med 27:1518-25. 2001
    OBJECTIVE: To determine: 1) if dobutamine elicited a thermogenic response during postnatal development; and 2) if this response impacted on the balance between systemic O(2) delivery (DO(2)) and O(2) consumption (VO(2)), and involved one ..
  22. pmc The role of dobutamine stress cardiovascular magnetic resonance in the clinical management of patients with suspected and known coronary artery disease
    Rolf Gebker
    German Heart Institute Berlin, Germany
    J Cardiovasc Magn Reson 13:46. 2011
    Recent studies have demonstrated the consistently high diagnostic and prognostic value of dobutamine stress cardiovascular magnetic resonance (DCMR). The value of DCMR for clinical decision making still needs to be defined...
  23. ncbi Management of scorpion sting: prazosin or dobutamine
    B D Gupta
    Department of Pediatrics, Umaid Hospital for Women and Children, Regional Institute of Maternal and Child Health, Dr Sampurnanand Medical College, Jodhpur, India
    J Trop Pediatr 56:115-8. 2010
    To compare the efficacy of Dobutamine and Prazosin in the management of cases with scorpion sting.
  24. ncbi Long-term prognostic value of dobutamine stress CMR
    Sebastian Kelle
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    JACC Cardiovasc Imaging 4:161-72. 2011
    The aim of this study was to assess the long-term value of high-dose dobutamine cardiac magnetic resonance (DCMR) for the prediction of cardiac events in a large cohort of patients with known or suspected coronary artery disease.
  25. ncbi Quantitation of myocardial borderzone using reconstructive 3-D echocardiography after chronic infarction in rats: incremental value of low-dose dobutamine
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Ultrasound Med Biol 34:559-66. 2008
    ..in scar and myocardial borderzone size assessment and (ii) to investigate the incremental value of low-dose dobutamine stress...
  26. ncbi Incremental value of strain rate analysis as an adjunct to wall-motion scoring for assessment of myocardial viability by dobutamine echocardiography: a follow-up study after revascularization
    Lizelle Hanekom
    Princess Alexandra Hospital, Department of Medicine, University of Queensland, Brisbane, Australia
    Circulation 112:3892-900. 2005
    Assessment of myocardial viability based on wall-motion scoring (WMS) during dobutamine echocardiography (DbE) is difficult and subjective...
  27. ncbi Myocardial viability during dobutamine echocardiography predicts survival in patients with coronary artery disease and severe left ventricular systolic dysfunction
    I Afridi
    Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, USA
    J Am Coll Cardiol 32:921-6. 1998
    The purpose of this study was to assess whether the presence or absence of myocardial viability during dobutamine echocardiography (DE) predicts survival in patients with coronary artery disease (CAD) and severe left ventricular (LV) ..
  28. ncbi Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure
    DeWayne Townsend
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
    Mol Ther 15:1086-92. 2007
    ..the baseline end-diastolic volume defect in the mdx mouse heart and prevented cardiac pump failure induced by dobutamine stress testing in vivo, although several parameters of systolic function were not corrected...
  29. ncbi Dobutamine stress echocardiography in women with systemic lupus erythematosus: increased occurrence of left ventricular outflow gradient
    S Codish
    Department of Internal Medicine D, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Lupus 13:101-4. 2004
    b>Dobutamine stress echocardiography (DSE) is an accurate noninvasive test used for the diagnosis and evaluation of patients with known or suspected coronary artery disease (CAD)...
  30. ncbi The Ca2+-sensitizer levosimendan improves oxidative damage, BNP and pro-inflammatory cytokine levels in patients with advanced decompensated heart failure in comparison to dobutamine
    Catherine Avgeropoulou
    State Cardiology Department, Hippokration Hospital, 114 Vassilissis Sophias, Athens, Greece
    Eur J Heart Fail 7:882-7. 2005
    To investigate the effect of a new inotropic drug, levosimendan compared with dobutamine on levels of brain natriuretic peptide (BNP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and malondialdehyde (MDA) in patients ..
  31. ncbi Randomized trial of dobutamine versus dopamine in preterm infants with low systemic blood flow
    David Osborn
    Department of Neonatal Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    J Pediatr 140:183-91. 2002
    Our purpose was to determine if dobutamine or dopamine results in greater improvements in systemic blood flow in very preterm infants with low flow during the first 24 hours of life.
  32. ncbi Impaired cardiac functional reserve and left ventricular hypertrophy in adult sheep after prenatal dexamethasone exposure
    M Dodic
    Howard Florey Institute, University of Melbourne, Department of Cardiology, Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia
    Circ Res 89:623-9. 2001
    ..The wedge pressure was held constant during an infusion of dobutamine at incremental doses (0.4 to 12 microgram/kg/min) while blood pressure and cardiac output were measured...
  33. ncbi Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiography
    E Nagel
    Department of Internal Medicine Cardiology, German Heart Institute and Charité Campus Virchow, Humboldt University, Berlin, Germany
    Circulation 99:763-70. 1999
    The analysis of wall motion abnormalities with dobutamine stress echocardiography (DSE) is an established method for the detection of myocardial ischemia...
  34. ncbi Effects of dobutamine on gut mucosal nitric oxide production during endotoxic shock in rabbits
    Suzana M Lobo
    Department of Medicine, Division of Intensive Care Medicine, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Paulo, Brazil
    Med Sci Monit 15:BR37-42. 2009
    b>Dobutamine is the agent of choice for increasing cardiac output during myocardial depression in humans with septic shock...
  35. ncbi Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats
    Takehisa Abe
    Department of Physiology II, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Am J Physiol Heart Circ Physiol 282:H138-48. 2002
    ..001) lower in severe DM rats. We conclude that the only lusitropic dysfunction due to the depressed expression of SERCA2 is related to generating diabetic cardiomyopathy even in the present type 2 diabetic rats...
  36. ncbi Prognostic value of cardiac magnetic resonance stress tests: adenosine stress perfusion and dobutamine stress wall motion imaging
    Cosima Jahnke
    Department of Internal Medicine Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Circulation 115:1769-76. 2007
    Adenosine stress magnetic resonance perfusion (MRP) and dobutamine stress magnetic resonance (DSMR) wall motion analyses are highly accurate for the detection of myocardial ischemia...
  37. ncbi Comparison of norepinephrine-dobutamine to epinephrine for hemodynamics, lactate metabolism, and organ function variables in cardiogenic shock. A prospective, randomized pilot study
    Bruno Levy
    Service de Reanimation Medicale, CHU Nancy Brabois, Vandoeuvre les Nancy, France
    Crit Care Med 39:450-5. 2011
    ..Hence, the present study was designed to compare epinephrine and norepinephrine-dobutamine in dopamine-resistant cardiogenic shock.
  38. ncbi Importance of diastolic fractional flow reserve and dobutamine challenge in physiologic assessment of myocardial bridging
    Javier Escaned
    Interventional Cardiology Service, Cardiovascular Institute, Hospital Clinico San Carlos, Madrid, Spain
    J Am Coll Cardiol 42:226-33. 2003
    ..This study reports a comparative assessment of the hemodynamic relevance of myocardial bridges (MB) using two modalities of fractional flow reserve (FFR), with and without concomitant inotropic challenge...
  39. pmc Left ventricular hypertrophy influences cardiac prognosis in patients undergoing dobutamine cardiac stress testing
    Charaslak Charoenpanichkit
    Departments of Internal Medicine Cardiology Section, Public Health Sciences, Biomedical Engineering, and Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Circ Cardiovasc Imaging 3:392-7. 2010
    This study was performed to determine the utility of dobutamine stress test results for predicting myocardial infarction (MI) and cardiac death in patients with chest pain and left ventricular hypertrophy (LVH).
  40. ncbi Single Tc99m Sestamibi injection, double acquisition gated SPECT after stress and during low-dose dobutamine infusion: a new suggested protocol for evaluation of myocardial perfusion
    Babak Fallahi
    Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran
    Int J Cardiovasc Imaging 24:825-35. 2008
    The ability of low dose dobutamine (LDD) has been established in exploiting the reserved contractility of ischemic myocardium...
  41. ncbi Levosimendan improves renal function in patients with acute decompensated heart failure: comparison with dobutamine
    Mehmet Birhan Yilmaz
    Department of Cardiology, Cumhuriyet University Faculty of Medicine, 584140, Sivas, Turkey
    Cardiovasc Drugs Ther 21:431-5. 2007
    ..This study was conducted to investigate the effects of levosimendan (L) and dobutamine (D) on renal function in patients hospitalized with decompensated heart failure (HF).
  42. ncbi Myocardial viability assessment in patients with highly impaired left ventricular function: comparison of delayed enhancement, dobutamine stress MRI, end-diastolic wall thickness, and TI201-SPECT with functional recovery after revascularization
    M Gutberlet
    Charite, Campus Virchow Klinikum, Klinik fur Strahlenheilkunde, Diagnostic Radiology and Nuclear Medicine, Berlin, Germany
    Eur Radiol 15:872-80. 2005
    ..Wall-motion abnormalities were assessed by stress cine MRI using low-dose dobutamine. A segment with a nonreversible defect in Tl(201)-SPECT and a delayed enhancement (DE) in an area >50% of the ..
  43. ncbi The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis
    M Ryden
    Department of Medicine, Karolinska Institutet at Huddinge Hospital, Huddinge, Sweden
    Int J Obes Relat Metab Disord 25:1599-603. 2001
    ..The beta1-adrenoceptor is a candidate gene for obesity because of its role in catecholamine-induced energy homeostasis. A common Arg 389 Gly variant polymorphism has been shown in recombinant cells to influence its-coupling properties...
  44. ncbi Strain-encoded CMR for the detection of inducible ischemia during intermediate stress
    Grigorios Korosoglou
    University of Heidelberg, Department of Cardiology, Heidelberg, Germany
    JACC Cardiovasc Imaging 3:361-71. 2010
    ..This study sought to evaluate the diagnostic accuracy of strain-encoded cardiac magnetic resonance (SENC) for the detection of inducible ischemia during intermediate stress...
  45. ncbi Magnetic resonance stress tagging in ischemic heart disease
    Ingo Paetsch
    German Heart Institute Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Am J Physiol Heart Circ Physiol 288:H2708-14. 2005
    High-dose dobutamine magnetic resonance stress testing has been shown to be superior to dobutamine stress echocardiography for diagnosis of coronary artery disease (CAD)...
  46. ncbi The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a dose-response study in newborn pigs
    Zakariya Al-Salam
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Shock 28:317-25. 2007
    ..A randomized controlled study was designed to examine the dose-response effect of dobutamine (5-20 microg x kg(-1) x min(-1)) on systemic and regional circulations and oxygen metabolism in a neonatal swine ..
  47. ncbi Left ventricular outflow tract obstruction provoked during dobutamine stress echocardiography predicts future chest pain, syncope, and near syncope
    Buddhadeb Dawn
    Division of Cardiology, Department of Medicine, University of Louisville, and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    Am Heart J 149:908-16. 2005
    Although dobutamine stress echocardiography (DSE) is associated with dynamic left ventricular (LV) obstruction, it is unknown whether such obstructive event, in general, and the specific site of obstruction, in particular, have unique ..
  48. ncbi [Dobutamine stress echocardiography; a monocentric experience on 600 consecutive patients. Effect of age]
    N Lamisse
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 90:1455-61. 1997
    The increasing indications of dobutamine stress echo in the investigation of myocardial ischaemia, viability and evaluation of the prognosis of coronary artery disease has made this technique a tool of everyday clinical practice...
  49. ncbi Impact of beta-myosin heavy chain expression on cardiac function during stress
    Maike Krenz
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Am Coll Cardiol 44:2390-7. 2004
    ..Therefore, using transgenic (TG) mice, we tested how a pre-existing shift from alpha- to beta-MHC affects cardiac function under chronic mechanical or pharmacologic cardiovascular stress...
  50. ncbi Incremental value of 2-dimensional speckle tracking strain imaging to wall motion analysis for detection of coronary artery disease in patients undergoing dobutamine stress echocardiography
    Arnold C T Ng
    Department of Cardiology, Liverpool Hospital, University of New South Wales, Sydney, NSW, Australia
    Am Heart J 158:836-44. 2009
    Interpretation of dobutamine stress echocardiogram (DSE) is often subjective and requires expert training...
  51. ncbi Pressure-volume relationship during dobutamine stress echocardiography predicts exercise tolerance in patients with congestive heart failure
    Quirino Ciampi
    Division of Cardiology, Fatebenefratelli Hospital, Benevento, Italy
    J Am Soc Echocardiogr 23:71-8. 2010
    ..relationship (PVR) is a useful method for evaluating left ventricular (LV) myocardial contractility during dobutamine stress echocardiography (DSE)...
  52. ncbi Dobutamine for patients with severe heart failure: a systematic review and meta-analysis of randomised controlled trials
    Catherine L Tacon
    Intensive Care Unit, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia
    Intensive Care Med 38:359-67. 2012
    b>Dobutamine is recommended for patients with severe heart failure; however uncertainty exists as to its effect on mortality...
  53. ncbi Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs
    Lothar A Schwarte
    Department of Anesthesiology, University Hospital of Dusseldorf, Germany
    Crit Care Med 33:135-42; discussion 246-7. 2005
    ..We compared systemic and regional effects of levosimendan with those of established inotropes, milrinone and dobutamine.
  54. pmc Cardiovascular magnetic resonance myocardial feature tracking detects quantitative wall motion during dobutamine stress
    Andreas Schuster
    King s College London British Heart Foundation Centre of Excellence, London, UK
    J Cardiovasc Magn Reson 13:58. 2011
    b>Dobutamine stress cardiovascular magnetic resonance (DS-CMR) is an established tool to assess hibernating myocardium and ischemia. Analysis is typically based on visual assessment with considerable operator dependency...
  55. ncbi Evaluation of left anterior descending coronary artery stenosis of intermediate severity using transthoracic coronary flow reserve and dobutamine stress echocardiography
    Patrick Meimoun
    Compiègne Hospital, Compiegne, France
    J Am Soc Echocardiogr 18:1233-40. 2005
    ..Assessment of coronary flow reserve (CFR) by Doppler transthoracic echocardiography (TTE) is a new tool and could allow rapid, noninvasive evaluation of stenosis severity in this setting...
  56. ncbi Quantitative analysis of function and perfusion during dobutamine stress in the detection of coronary stenoses: two-dimensional strain and contrast echocardiography investigations
    Patricia Reant
    INSERM U828, IFR4, Pessac, France
    J Am Soc Echocardiogr 23:95-103. 2010
    The recent development of accurate methods to measure two-dimensional strain during dobutamine stress echocardiography has reactivated the debate as to the respective value of myocardial perfusion versus myocardial function assessment in ..
  57. ncbi A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription
    Yijun Bao
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Biochem 150:199-208. 2011
    ..Using this method, we found that dobutamine inhibits the YAP-dependent gene transcription...
  58. ncbi Usefulness of low-dose dobutamine echocardiography to predict response and outcome in patients undergoing cardiac resynchronization therapy
    Robert K Altman
    Cardiac Arrhythmia Service, Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Am J Cardiol 108:252-7. 2011
    ..The present study prospectively evaluated the effect of contractile reserve and dobutamine-induced changes in LV synchrony, in relation to the LV lead location, as predictors of the response to CRT...
  59. pmc Left atrial passive emptying function during dobutamine stress MR imaging is a predictor of cardiac events in patients with suspected myocardial ischemia
    Afshin Farzaneh-Far
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    JACC Cardiovasc Imaging 4:378-88. 2011
    The aim of this study was to determine the prognostic value of assessing left atrial function during dobutamine stress testing.
  60. pmc Target heart rate to determine the normal value of coronary flow reserve during dobutamine stress echocardiography
    Ezequiel H Forte
    Investigaciones Médicas, Buenos Aires, Argentina
    Cardiovasc Ultrasound 9:10. 2011
    ..There are several direct and indirect tests to evaluate this parameter. In this sense, dobutamine stress echocardiography is one of the pharmacological method most commonly used worldwide...
  61. ncbi Effect of tissue Doppler on the accuracy of novice and expert interpreters of dobutamine echocardiography
    R Fathi
    University of Queensland, Brisbane, Australia
    Am J Cardiol 88:400-5. 2001
    The subjective interpretation of dobutamine echocardiography (DBE) makes the accuracy of this technique dependent on the experience of the observer, and also poses problems of concordance between observers...
  62. ncbi Dobutamine enhances alveolar fluid clearance in a rat model of acute lung injury
    Xing Mao Wu
    Intensive Care Unit, Shengjing Hospital, China Medical University, Liaoning, China
    Lung 187:225-31. 2009
    ..The present study was designed to determine whether the administration of dobutamine decreases pulmonary edema and stimulates AFC in a rat model of lipopolysaccharide-induced lung injury...
  63. ncbi Differences in need for hemodynamic support in horses anesthetized with sevoflurane as compared to isoflurane
    Bernd Driessen
    Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, Section of Critical Care Anesthesia, University of Pennsylvania, PA 19348, USA
    Vet Anaesth Analg 33:356-67. 2006
    ..To study whether hemodynamic function in horses, particularly mean arterial blood pressure (MAP), is better maintained with sevoflurane than isoflurane, thus requiring less pharmacological support...
  64. ncbi The effects of dobutamine on renal sympathetic activity in human heart failure
    Abdul Al-Hesayen
    Department of Medicine, Division of Cardiology, St Michael s Hospital, Canada
    J Cardiovasc Pharmacol 51:434-6. 2008
    ..b>Dobutamine is commonly used in the treatment of decompensated heart failure...
  65. pmc Right ventricular pressure and dilation during pressure overload determine dysfunction after pressure overload
    C Greyson
    Cardiology Section, Department of Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    Am J Physiol Heart Circ Physiol 278:H1414-20. 2000
    ..closing or opening the pericardium (to simulate volume expansion) and by administering or not administering dobutamine. The severity of RV free wall dysfunction 1 h after RV pressure overload was strongly and directly correlated ..
  66. ncbi Recombinant human matrix metalloproteinase-2 impairs cardiovascular β-adrenergic responses
    Karina C Ferraz
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Basic Clin Pharmacol Toxicol 112:103-9. 2013
    ..to anaesthetized lambs at baseline conditions and during β(1) -adrenergic cardiac stimulation with dobutamine. We used 26 anaesthetized male lambs in two study protocols. First, rhMMP-2 (220 ng/kg/min. over 60 min...
  67. pmc Early detection of left ventricular dysfunction in patients with beta thalassaemia major by dobutamine stress echocardiography
    L Hui
    Heart 89:669-70. 2003
  68. ncbi Effects of dobutamine on cardiac index and arterial blood pressure in isoflurane-anaesthetized horses under clinical conditions
    A de Vries
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    J Vet Pharmacol Ther 32:353-8. 2009
    Volatile agent-induced hypotension may contribute to anaesthetic-related morbidity and mortality in horses. Dobutamine is commonly used to support arterial blood pressure (ABP) but little is known about its cardiovascular effects under ..
  69. ncbi [Catecholamines use in patients with heart failure]
    Kenji Iino
    The Internal Medicine Cardiology and Respiratory, Akita University School of Medicine
    Nihon Rinsho 65:30-3. 2007
  70. ncbi [Catecholamines--characteristics, mechanisms of action, pharmacokinetics, indications, contraindications, clinical trials, and side effects]
    Yutaka Kagaya
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
    Nihon Rinsho 65:25-9. 2007
  71. ncbi Ephedrine, dopamine, or dobutamine to treat hypotension with propofol during epidural anesthesia
    T Kasaba
    Department of Anesthesiology, Miyazaki Medical College, Japan
    Can J Anaesth 47:237-41. 2000
    To compare the efficacy of ephedrine, dopamine and dobutamine for circulatory support during thoracic epidural anesthesia after anesthetic induction with propofol.
  72. ncbi Effects of dopamine, dobutamine, amrinone and milrinone on regional blood flow in isoflurane anesthetized dogs
    Denji Tobata
    Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 66:1097-105. 2004
    The effects of cyclic AMP increasing cardiotonics (dopamine, dobutamine, amrinone and milrinone) on the blood flow in most organs were compared using colored microsphere technique in isoflurane-anesthetized dogs...
  73. ncbi Gender-specific differences in myocardial deformation and aortic stiffness at rest and dobutamine stress
    Valentina O Puntmann
    Department of Cardiology and Internal Medicine, German Heart Institute Berlin, Berlin, Germany
    Hypertension 59:712-8. 2012
    ..years) were assessed for aortic stiffness by pulse wave velocity and ventricular deformation at rest and during dobutamine stress using magnetic resonance...
  74. ncbi Cardiac remodeling and contractile function in acid alpha-glucosidase knockout mice
    J H Kamphoven
    Department of Clinical Genetics, Experimental Cardiology, Thoraxcenter, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Physiol Genomics 5:171-9. 2001
    ..4,440 +/- 440 mmHg/s) and during dobutamine infusion (6,220 +/- 800 vs. 8,730 +/- 790 mmHg/s, both P < 0.05)...
  75. ncbi Catecholamines, parasympathetic stimuli, or cortisol for overwhelming sepsis?
    A B Johan Groeneveld
    Crit Care Med 34:1549-50. 2006
  76. ncbi Effects of dopexamine, dobutamine or dopamine on prolactin and thyreotropin serum concentrations in high-risk surgical patients
    Thomas Schilling
    Department of Anaesthesiology and Intensive Care Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Intensive Care Med 30:1127-33. 2004
    ..The objective was to compare endocrine effects of equipotent inotropic doses of dopexamine, dobutamine and dopamine on prolactin and thyreotropin release perioperatively.
  77. ncbi Longitudinal Doppler strain measurement for assessment of damaged and/or hibernating myocardium by dobutamine stress echocardiography in patients with old myocardial infarction
    Hiroyuki Fujimoto
    Department of Internal Medicine, Division of Cardiology, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Cardiol 55:309-16. 2010
    ..We hypothesized that measuring the postsystolic index (PSI) and the L/TS ratio during dobutamine stress echocardiography (DSE) could quantitatively identify viable myocardium with the potential for regional ..
  78. ncbi Patients after atrial switch operation for transposition of the great arteries can not increase stroke volume under dobutamine stress as opposed to patients with congenitally corrected transposition
    Sohrab Fratz
    Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Munchen, Klinik an der Technischen Universität München, Lazarettstrasse 36, 80636 Munich, Germany
    Circ J 72:1130-5. 2008
    ..Therefore the aim of this study was to test the impact of atrial baffles by comparing 12 atrial switch patients with 11 ccTGA patients...
  79. ncbi Placebo or trimetazidine (99m)Tc tetrofosmin myocardial SPECT and low-dose dobutamine echocardiography in hibernating myocardium
    Mauro Feola
    Department of Cardiovascular Diseases, Nuclear Medicine Service, Ospedale Santa Croce e Carle Cuneo, Cuneo, Italy
    Arch Med Res 37:117-22. 2006
    ..This study compared TMZ (99m)Tc tetrofosmin SPECT and low-dose dobutamine echocardiography (LDDE) as predictors of functional recovery of hibernating myocardium after coronary ..
  80. ncbi Behavioral effects of beta adrenergic agonists and antidepressant drugs after down-regulation of beta-2 adrenergic receptors by clenbuterol
    J M O'Donnell
    Life Sciences Division, Los Alamos National Laboratory, New Mexico
    J Pharmacol Exp Ther 254:147-57. 1990
    ..By contrast, the effects of the beta-1 selective agonists dobutamine and prenalterol and the antidepressants desipramine, phenelzine and fluoxetine on DRL behavior were unaltered ..
  81. ncbi Arterial baroreflex control of the sinus node during dobutamine exercise stress testing
    P van de Borne
    Hypertension Clinic, Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Hypertension 33:987-91. 1999
    ..We used a dobutamine infusion to induce hemodynamic changes comparable to those of moderate physical exercise in the absence of ..
  82. pmc Activation of β-adrenoceptors by dobutamine may induce a higher expression of peroxisome proliferator-activated receptors δ (PPARδ) in neonatal rat cardiomyocytes
    Ming Ting Chou
    Department of Cardiology and Department of Medical Research, Chi Mei Medical Center, Yong Kang, Tainan 73101, Taiwan
    ScientificWorldJournal 2012:248320. 2012
    ..Because dobutamine is an agent widely used to treat heart failure in emergency setting, this study is aimed to investigate the ..
  83. ncbi Tissue velocity imaging with dobutamine stress echocardiography--a quantitative technique for identification of coronary artery disease in patients with left bundle branch block
    Hala Mahfouz Badran
    Cardiology Department, Faculty of Medicine, Menoufiya University, Shebin Elkom, and Cardiology Department, Tanta University, Tanta, Egypt
    J Am Soc Echocardiogr 20:820-31. 2007
    ..Patients with left bundle branch block (LBBB) exhibit abnormal septal motion that may limit the interpretation of stress echocardiograms and persuade the results of myocardial scintigraphy...
  84. ncbi Assessment of the functional status of heart failure in non ischemic dilated cardiomyopathy: an echo-dobutamine study
    I A Paraskevaidis
    2nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
    Cardiovasc Res 43:58-66. 1999
    ..b>Dobutamine echocardiography can be used to evaluate myocardial reserve...
  85. pmc Alteration of left ventricular function with dobutamine challenge in patients with myocardial bridge
    Joon Hyung Jhi
    Division of Cardiology, Department of Internal Medicine, Maryknoll Medical Center, Busan, Korea
    Korean J Intern Med 26:410-20. 2011
    ..The aim of this study was to identify changes in left ventricular (LV) performance in patients with a myocardial bridge (MB) in the left anterior descending coronary artery during resting and in an inotropic state...
  86. ncbi Comparison of terbutaline and dobutamine in rats with endotoxemia
    Jeng Yuan Wu
    Division of Thoracic Surgery, Taichung Army General Hospital, Taichung, Taiwan, ROC
    Chin J Physiol 45:155-62. 2002
    ..Terbutaline (an agonist of beta2-adrenoceptor) and dobutamine (an agonist of beta1-adrenoceptor), both are able to increase intracellular cAMP via activation of adenylate ..
  87. ncbi Usefulness of dobutamine stress echocardiography with Tissue Doppler imaging for the evaluation and follow-up of patients with repaired tetralogy of Fallot
    Stella Brili
    First Department of Cardiology, Athens Medical School, Hippokratio Hospital, Athens, Greece
    J Am Soc Echocardiogr 21:1093-8. 2008
    ..b>Dobutamine stress echocardiography (DSE) in low doses detects the contractility reserve of cardiac myocytes...
  88. ncbi Safety and predictors of complications with a new accelerated dobutamine stress echocardiography protocol
    Jose Alberto San Roman
    Institute of Heart Sciences ICICOR, Clinic University Hospital of Valladolid, Valladolid, Spain
    J Am Soc Echocardiogr 21:53-7. 2008
    This study sought to document the safety of a new accelerated dobutamine-atropine stress echocardiography protocol and to analyze its complications.
  89. ncbi Noradrenaline for management of septic shock refractory to fluid loading and dopamine or dobutamine in full-term newborn infants
    Pierre Tourneux
    Clinique de Médecine Néonatale, Hopital Jeanne de Flandre, CHRU de Lille, France
    Acta Paediatr 97:177-80. 2008
    ..To determine the effects of noradrenaline in full-term newborns with refractory septic shock...
  90. ncbi Influence of wall stress and left ventricular geometry on the accuracy of dobutamine stress echocardiography
    Satoshi Yuda
    University of Queensland, Brisbane, Australia
    J Am Coll Cardiol 40:1311-9. 2002
    The goal of this study was to determine whether wall stress at rest and during stress could explain the influence of left ventricular (LV) morphology on the accuracy of dobutamine stress echocardiography (DSE).
  91. ncbi The haemodynamic effects of propranolol and atenolol medication on dobutamine infusion in patients with coronary artery obstructive disease
    Y J Oh
    Department of Anaesthesiology and Pain Medicine, Yonsei University School of Medicine, Seoul, Korea
    J Int Med Res 33:329-36. 2005
    We compared the haemodynamic effects of beta-blockers on dobutamine infusion in 60 patients undergoing coronary artery bypass graft surgery...
  92. ncbi Postoperative sublingual microcirculatory derangement following esophagectomy is prevented with dobutamine
    Michel van Genderen
    Department of Intensive Care, Erasmus MC, Rotterdam, The Netherlands
    Clin Hemorheol Microcirc 48:275-83. 2011
    ..Similar observations in severely septic patients could be treated with dobutamine, independent of cardiac output...
  93. ncbi Treatment of impaired perfusion in septic shock
    Esko Ruokonen
    Department of Intensive Care, Kuopio University Hospital, PO Box 1777, FI 70210 KUOPIO, Finland
    Ann Med 34:590-7. 2002
    ..low vascular resistance is norepinephrine, while insufficient myocardial contractility is commonly treated with dobutamine. The use of norepinephrine seems to be associated with better prognosis as compared to results from the use of ..
  94. ncbi Identification of hibernating myocardium with quantitative intravenous myocardial contrast echocardiography: comparison with dobutamine echocardiography and thallium-201 scintigraphy
    Sarah Shimoni
    Section of Cardiology, Department of Medicine, Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Tex 77030, USA
    Circulation 107:538-44. 2003
    ..no data on the accuracy of intravenous myocardial contrast echocardiography (MCE) in detecting myocardial hibernation in man and its comparative accuracy to dobutamine echocardiography (DE) or thallium 201 (Tl(201)) scintigraphy.
  95. ncbi Role of norepinephrine in development of short-term myocardial hibernation
    Zuo lin Fu
    The Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Acta Pharmacol Sin 27:158-64. 2006
    ..To investigate the role of norepinephrine in the development of short-term myocardial hibernation...
  96. ncbi Dobutamine does not influence inflammatory pathways during human endotoxemia
    Lucienne C Lemaire
    Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care Med 34:1365-71. 2006
    Catecholamines have anti-inflammatory and anticoagulant properties. Dobutamine is a synthetic catecholamine frequently used in patients with septic myocardial dysfunction...
  97. ncbi Prognostic value of combined assessment of regional left ventricular function and myocardial perfusion by dobutamine and rest gated SPECT in patients with uncomplicated acute myocardial infarction
    Letizia Spinelli
    Institute of Internal Medicine, Cardiology and Heart Surgery, University Federico II, Naples, Italy
    J Nucl Med 44:1023-9. 2003
    ..The aim of this study was to address the prognostic value of gated SPECT performed during dobutamine stress testing and during rest on patients with acute myocardial infarction treated with thrombolysis.
  98. ncbi The feasibility of ultrasonic regional strain and strain rate imaging in quantifying dobutamine stress echocardiography
    M Kowalski
    University Hospital Gasthuisberg, Department of Cardiology, Leuven, Belgium
    Eur J Echocardiogr 4:81-91. 2003
    ..In theory, these deformation indices could be used to quantify normal or abnormal regional function during a dobutamine stress echo test.
  99. ncbi Myocardial metabolism of 123I-BMIPP under low-dose dobutamine infusion: implications for clinical SPECT imaging of ischemic heart disease
    Ryohei Hosokawa
    Department of Cardiovascular Medicine, and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Eur J Nucl Med Mol Imaging 32:75-83. 2005
    ..Low-dose dobutamine infusion has been reported to improve BMIPP uptake in the stunned myocardium, but the mechanism underlying this ..
  100. ncbi The correlation between expression of apoptosis-related proteins and myocardial functional reserve evaluated by dobutamine stress echocardiography in patients with dilated cardiomyopathy
    Yi Lwun Ho
    Department of Internal Medicine, National Taiwan University Hospital, Taipei
    J Am Soc Echocardiogr 16:931-6. 2003
    ..The purpose of this study was to assess this issue through the use of dobutamine stress echocardiography...
  101. pmc Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats
    Yoshitaka Iwanaga
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0613B, USA
    J Clin Invest 113:727-36. 2004
    ..Thus, PLN inhibition by in vivo rAAV gene transfer is an effective strategy for the chronic treatment of an acquired form of established heart failure...

Research Grants62

  1. Surgical Revascularization's Impact on Mitochondria in Hibernating Myocardium
    ROSEMARY FRANCES KELLY; Fiscal Year: 2013
    ..evaluate whether surgical revascularization normalizes regional blood flow at rest and with increased work load (dobutamine stress) by measuring blood flow (microsphere analysis) and cardiac function (2D ECHO, MDCT)...
  2. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2012
    ..The impact of microrevascularization on ischemic myocardial contractility will be determined with dobutamine stress echocardiography and myocardial tissue properties will be studied utilizing atomic force microscopy and ..
  3. Reduced contractile reserve: a therapeutic target in heart failure with normal EF
    Nancy K Sweitzer; Fiscal Year: 2012
    ..HFpEF by investigating the change in ejection fraction before and after 2-adrenergic stimulation with low-dose dobutamine in HFpEF compared to other groups important to distinguish clinically, specifically patients with shortness of ..
  4. Molecular Imaging of Ischemic Memory with Ultrasound - Transition to Humans
    Jonathan R Lindner; Fiscal Year: 2010
    ..ischemia in patients referred for non-invasive evaluation for coronary artery disease with stress or dobutamine echocardiography...
  5. Cardiac Imaging of Thoracic Fat and Aortic Stiffness in Older High Risk Patients
    Tina E Brinkley; Fiscal Year: 2013
    ..study to the Vascular Stiffness and Pulmonary Edema Study, a prospective study examining the association between dobutamine stress-induced changes in aortic stiffness and flash pulmonary edema warranting hospital admission in older high ..
  6. Acute and Chronic Regulation of 20S Proteasome Function by cAMP-Dependent Kinase
    SARAH SCRUGGS; Fiscal Year: 2012
    ..Cardiomyocytes will be treated with dobutamine and kinetics of 20S phosphorylation, subunit association, and PKA translocation to the 20S complex will be ..
  7. 3D Myocardial Strain Vectors in Ischemic Heart Disease
    Brian P Cupps; Fiscal Year: 2010
    ..Research Design and Methods. We will use MRI-based multiparametric strain analysis dobutamine provocation to study patients with akinetic LV regions that are served by atherosclerotic coronary arteries upon ..
  8. Mid Atlantic Heart Failure Network
    KENNETH BER MARGULIES; Fiscal Year: 2013
    ..recurrent hospitalization and several secondary endpoints including myocardial contractile reserve assessed via dobutamine stress echocardiography, 6-minute walk distance, quality of life...
  9. Washington D.C. Collaborative PPRU
    John van den Anker; Fiscal Year: 2009
    ..models for optimizing the treatment of neonatal pain (morphine), and the use of off-patent drugs (dopamine and dobutamine)...
  10. Model-Based Design of Wall Motion Measures for 4-Dimensional Cardiac Imaging
    Jeffrey W Holmes; Fiscal Year: 2012
    ..cardiologists;(2) to test the hypothesis that reduced three-dimensional fractional shortening (3DFS) during dobutamine stress detects and localizes regions of angiographically confirmed coronary artery disease with better accuracy ..
  11. QUANTITATIVE ULTRASONIC IMAGING FOR MYOCARDIAL VIABILITY
    Julio Perez; Fiscal Year: 1999
    ..conventional echocardiography, ultrasonic integrated backscatter imaging, frequency dependence of backscatter, dobutamine stress echocardiography and myocardial contrast echocardiography...
  12. PARADIGM SHIFTS IN CLINICAL ISCHEMIA DETECTION
    Philip Binkley; Fiscal Year: 2002
    ..Patients with ischemic cardiomyopathy will each be evaluated by dobutamine thallium perfusion studies, adenosine sestaMIBI studies, contrast echocardiography, and endocardial catheter ..
  13. Central betal adrenergic receptors and behavior
    Han Ting Zhang; Fiscal Year: 2004
    ..the non-selective beta adrenergic receptor agonist isoproterenol, selective beta-1and beta-2 adrenergic agonists dobutamine and clenbuterol, respectively, and the antidepressants desipramine and fluoxetine on forced-swim behavior in the ..
  14. PARADIGM SHIFTS IN CLINICAL ISCHEMIA DETECTION
    Philip Binkley; Fiscal Year: 2004
    ..Patients with ischemic cardiomyopathy will each be evaluated by dobutamine thallium perfusion studies, adenosine sestaMIBI studies, contrast echocardiography, and endocardial catheter ..
  15. DETERMINANTS OF VASODILATOR RESPONSE IN HEART FAILURE
    Milton Packer; Fiscal Year: 1992
    ..binding proteins) and correlated with the responsiveness of patients of cyclic A MP-dependent inotropic drugs (dobutamine, glucagon and amrinone)...
  16. Imaging and Laser Revascularization in Hibernation
    Lynne Johnson; Fiscal Year: 2003
    ..Perfusion imaging and dobutamine echocardiography are being used clinically to identify dysfunctional viable myocardium and assess results of ..
  17. Diaphragm Fatigue Prevention in Emphysema
    NANCY SMITH BLAIR; Fiscal Year: 2006
    ..exercise conditioning and pharmacological improvement of diaphragm muscle function with intravenous infusions of dobutamine (DOB) are effective in abating the development of DF in EMP...
  18. Development of Poloxamer-188 for the Treatment of Muscular Dystrophy Associated H
    BRUCE MARKHAM; Fiscal Year: 2009
    ..from contraction-induced damage as dramatically evidenced by significantly improved survival of mice during a dobutamine challenge...
  19. BEDSIDE SYSTEM FOR COMBINED RNA AND PACIN HEART FAILURE
    Jeffrey Lacy; Fiscal Year: 2001
    ..evaluation of such patients, including quantitative examination of the effects of interventions, such as dobutamine and IV diuretics, as well as assessments of response to therapeutic dose levels...
  20. VASOACTIVE DRUGS AND NEONATAL CEREBROVASCULAR REACTIVITY
    DANILYN ANGELES; Fiscal Year: 2004
    ..basic science strategies to examine the effects of vasoactive pharmaceuticals such as indomethacin, dopamine and dobutamine on neonatal cerebrovascular reactivity...
  21. DECIPHER STICH
    JULIO PANZA; Fiscal Year: 2006
    The Dobutamine Echocardiography in Patients with Ischemic Heart failure Evaluated for Revascularization Study, as part of the Surgical Treatment for Ischemic Heart Failure Trial (DECIPHER-STICH), is designed to address the hypothesis that ..
  22. ELGAVIST, AN MRI CONTRAST AGENT FOR DIAGNOSIS OF IHD
    PAL SURANYI; Fiscal Year: 2000
    ..efficacy in the in vivo dog model of acute myocardial ischemia followed by reperfusion, with and without dobutamine-induced pharmacologic stress...
  23. CARDIAC ENERGY METABOLISM IN HEART FAILURE
    William Stanley; Fiscal Year: 2003
    ..heart in vivo in healthy and heart failure dogs under normal conditions and when cardiac work is increased with dobutamine. 2) Determine if cardiac mitochondria from dogs with heart failure have accelerated rates of fatty acid ..
  24. DECIPHER STICH
    JULIO PANZA; Fiscal Year: 2003
    The Dobutamine Echocardiography in Patients with Ischemic Heart failure Evaluated for Revascularization Study, as part of the Surgical Treatment for Ischemic Heart Failure Trial (DECIPHER-STICH), is designed to address the hypothesis that ..
  25. A NEW METHOD FOR ANALYSIS OF CORONARY ARTERY BEHAVIOR
    Thomas Williams; Fiscal Year: 1980
    ..g., epinephrine, nitroprusside, isoprotereral, dobutamine). The above studies will be repeated in the chronically collateralized coronary bed...
  26. PERFUSION AND METABOLISM IN COLLATERALIZED MYOCARDIUM
    ROBERT BACHE; Fiscal Year: 2001
    ..the ATP and PCr content in the collateral-dependent region during basal conditions, and examine the response to dobutamine. If contractile function fails to improve or deteriorates during a dobutamine, 31 P NMR spectroscopy will ..
  27. Beta-receptors and cardiovascular pharmacogenomics
    Julie Johnson; Fiscal Year: 2006
    ..research studies that will be conducted as part of this research career award include a study of dobutamine pharmacogenetics, and associations between the PAR genes and obesity or coronary microvascular dysfunction...
  28. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
    ..performed to obtain quantitative data about global and regional wall motion and blood flow at rest and stress (dobutamine and adenosine)...
  29. PREDICTION OF MYOCARDIAL RECOVERABILITY WITH 3D MRI
    Thoralf Sundt; Fiscal Year: 2002
    ..we believe most accurately reflect systolic function at the cellular level, by characterizing the response to dobutamine on a regional basis before and after surgical revascularization...
  30. LEFT VENTRICULAR REMODELING IN AORTIC INSUFFICIENCY
    Michael Pasque; Fiscal Year: 2009
    ..Although resting systolic strain was normal before surgery, the strain response to dobutamine was blunted - and neither was normal postoperatively - despite the fact that they were referred for surgery ..
  31. LEFT VENTRICULAR TIME-VARYING ELASTANCE
    William Little; Fiscal Year: 1990
    ..LV pressure and volume will be varied by caval occlusions. Inotropic state will be altered by dobutamine infusion, while loading conditions will be varied by infusion of methoxamine and dextran and by transient ..
  32. 4-DIMENSIONAL LV TISSUE TRACKING IN CAD FROM TAGGED MRI
    AMIR AMINI; Fiscal Year: 2002
    ..of segmental function scores from 3D + t (short-axis and long-axis) tagged MRI at rest and under pharmacologic (dobutamine) stress in normal controls...
  33. SIMULTANEOUS MRI DETECTION OF CARDIAC PERFUSION/FUNCTION
    GABRIEL ELGAVISH; Fiscal Year: 2003
    ..wall abnormality delineation be obtained in a relevant model of acute myocardial ischemia with stress created by dobutamine-enhanced demand for myocardial perfusion in conjunction with the creation of critical stenosis or with stress ..
  34. MECHANICS OF DIASTOLIC SUCTION
    Martin LeWinter; Fiscal Year: 2001
    ..Preliminary data indicate that 1) both systemic and intra-coronary (left anterior descending artery) dobutamine increase RFs and suction flow; 2) anterior wall transmural deformation patterns are especially important as a ..
  35. CONTRACTILITY OF FAILING AND RECOVERING HUMAN MYOCYTES
    Steven Houser; Fiscal Year: 2006
    ..the changes in cardiac performance caused by increases in heart rate (pacing stress) and adrenergic agonists (dobutamine stress)...
  36. Analysis Software to Characterize Myocardial Mechanics
    RICARDO ACTIS; Fiscal Year: 2004
    ..minimum principal strain and minimum principal strain vector determination at baseline and during low dose Dobutamine (viability) and high dose Dobutamine (ischemia/myocardial infartation) infusion...
  37. DYNAMIC 3D TAGGED MRI OF THE CARDIAC CYCLE IN ISCHEMIA
    Elias Zerhouni; Fiscal Year: 1999
    ..territory using graded levels of pharmacologic stress and repeated 3D measures of strain? Using graded Dobutamine challenges we will establish quantitatively (and, to our knowledge, for the first time) the exact correlation ..
  38. VALIDATION OF A NOVEL SARCOMERIC HIGH THROUGHPUT ASSAY
    Fady Malik; Fiscal Year: 2001
    ..The sales of non-generic dobutamine (Eli Lilly), used for acute heart failure, amounted to $86 million in 1998 (Paine Webber)...
  39. IS PROGRESSIVE FIBROSIS FATE OF HIBERNATING MYOCARDIUM?
    Chunguang Chen; Fiscal Year: 2001
    ..Daily dobutamine infusions will be used to try to exacerbate the progression of cell death and fibrosis...
  40. Strain-Encoded MR For Direct Imaging of Cardiac Function
    Nael Osman; Fiscal Year: 2006
    ..The system will run continuously during a dobutamine stress test, providing real-time monitoring of changes in regional function, and automatically detect ischemic ..
  41. NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
    Michael Givertz; Fiscal Year: 2003
    ..in contractile state by measuring LV end-systolic elastance during atrial pacing tachycardia and intracoronary dobutamine infusion in patients with dilated cardiomyopathy...
  42. Analysis Software to Characterize Myocardial Mechanics
    RICARDO ACTIS; Fiscal Year: 2001
    ..principal strain and minimum principal strain vector determination at baseline (viability) and during low dose Dobutamine (viability) and high dose Dobutamine (ischemia) infusion...
  43. 9.4 Tesla MR Scanner for Murine Imaging
    STUART BERR; Fiscal Year: 2005
    ..evaluation of myocardial function at rest, but would also enable the evaluation of contractile reserve during dobutamine infusion...
  44. Comprehensive MR Imaging of Elderly Vascular Function
    WILLIAM HUNDLEY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  45. MRI Detection of Doxorubicin Induced Cardiotoxicity
    WILLIAM HUNDLEY; Fiscal Year: 2007
    ..In addition, further animal studies will be designed to identify treatment strategies for Doxorubicin induced cardiotoxicity. [unreadable] [unreadable]..
  46. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..in AIM #3, we will test the relationship between in vivo transmural energy and function during high dose dobutamine and ex vivo expression of UCP-2...
  47. Comprehensive Magnetic Resonance in PAD
    Christopher Kramer; Fiscal Year: 2008
    ..Improving the health outcomes and quality of life in patients with PAD is a major goal of this proposal. ..
  48. REGIONAL BETA ADRENERGIC DURING LV REMODELING
    Christopher Kramer; Fiscal Year: 2002
    ..Effects of beta-blockade on regional cell morphometry, collagen content, and blood flow will be assessed using isolated myocytes, quantitative histopathology, and fluorescent microspheres, respectively. ..
  49. MODULATING ENERGETIC EFFICIENCY OF THE INOTROPIC STATE
    Guy Macgowan; Fiscal Year: 2003
    ..In this submission, a program of didactic training, mentorship, and research development is proposed, structured to develop the candidate's research training to eventual full independent status. ..
  50. Zebrafish TPSTs and Tyrosine-sulfated Proteins
    Ming Cheh Liu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  51. Venoarterial ECMO and neonatal cerebrovascular injury
    Billie Short; Fiscal Year: 2004
    ..These studies will also improve our understanding of the underlying mechanisms of ECMO-induced injury of cerebral arterial endothelium, and impairment in CBF autoregulation. ..
  52. PROGESTOGENS VS PHYTOESTROGENS-- AN ADJUNCT TO ERT
    James Williams; Fiscal Year: 2004
    ....
  53. Decision Making in End-Stage Heart Failure
    Paul Hauptman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  54. Dystrophic Cardiomyopathies in mdx
    DeWayne Townsend; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  55. Expert Visual Guidance of Ultrasound for Telemedicine
    Florence Sheehan; Fiscal Year: 2006
    ..Specific Aim #4 is to make the guidance easily applicable to different organs. [unreadable] [unreadable]..
  56. Nanoscale approaches to allelic silencing in myocardial disease states
    Euan Ashley; Fiscal Year: 2009
    ..This familial condition where the heart grows too thick is the most common cause of sudden death in young people and athletes. ..
  57. Multi-Modality Patient-Specific Evaluation of Ischemia
    Randolph Setser; Fiscal Year: 2006
    ..If successful, this proposal could enhance visualization of the effects of coronary artery disease in individual patients, thus enabling optimized revascularization planning tailored to the individual's anatomy. ..
  58. STICH Trial Radionuclide Core Laboratory
    Robert Bonow; Fiscal Year: 2007
    ..abstract_text> ..
  59. ENDOTHELIAL PROGENITOR CELLS FOR ENGINEERING VESSELS
    James Williams; Fiscal Year: 2008
    ..As such, these studies are an exciting and unique direction of research for Dr. Williams in collaboration with his colleagues at WFIRM. [unreadable] [unreadable] [unreadable]..
  60. MYOCARDIAL ENERGY METABOLISM IN THE DYSFUNCTIONAL LV
    Jianyi Zhang; Fiscal Year: 2003
    ..contributes to the transition between stable remodeling and CHF and, iii. Whether a metabolic intervention can attenuate the remodeling response and the transition from stable remodeling to CHF. ..