Genomes and Genes
Summary: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.
Publications223 found, 100 shown here
- New approaches to antidepressant drug discovery: beyond monoaminesOlivier Berton
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
Nat Rev Neurosci 7:137-51. 2006..This review summarizes the obstacles that have hindered the development of non-monoamine-based antidepressants, and provides a progress report on some of the most promising current strategies...
- A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognitionLucas Lecourtier
Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
Neurosci Biobehav Rev 31:658-72. 2007..Electrophysiological studies indicate a role in metaplasticity, the modulation of neuroplasticity. These studies thus reveal important roles of the habenular complex in learning, memory and attention...
- Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in ratsHideaki Obata
Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
J Pharmacol Exp Ther 334:1059-65. 2010..Combined administration of an SNRI with morphine might be a promising treatment to suppress postoperative hypersensitivity...
- Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio)J Kaslin
Department of Biology, Abo Akademi University, BioCity, FIN-20520 Turku/Abo, Finland
J Comp Neurol 440:342-77. 2001..The results also provide evidence of homologies to mammalian systems and allow identification of several previously uncharacterized systems in zebrafish mutants...
- The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeysDiane T Stephenson
Pfizer Global Research and Development, Groton, CT 06340, USA
J Pharmacol Exp Ther 314:1257-66. 2005..These results suggest that sumanirole can exert antiparkinsonian effects similar to L-DOPA without the behavioral and morphological consequences of the latter...
- Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studiesH G Ruhé
Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Mol Psychiatry 12:331-59. 2007..They presumably clarify a vulnerability trait to become depressed. Directions for further investigation of this vulnerability trait are proposed...
- Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytesDamijana Mojca Juric
Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Korytkova 2, SI 1000 Ljubljana, Slovenia
Brain Res 1108:54-62. 2006....
- Cerebrospinal fluid monoamine and metabolite concentrations and aggression in ratsBea J van der Vegt
Department of Animal Physiology, Biology, University of Groningen, Haren, The Netherlands
Horm Behav 44:199-208. 2003..Interpretation of CSF metabolite levels in terms of activity of neural substrates requires a far more detailed knowledge of the dynamics and kinetics of a neurotransmitter after its release...
- A matter of focus: monoaminergic modulation of stimulus coding in mammalian sensory networksL M Hurley
1001 East Third Street, Jordan Hall Biology Department, Indiana University, Bloomington, Indiana 47405, USA
Curr Opin Neurobiol 14:488-95. 2004....
- Formalin-induced nociception activates a monoaminergic descending inhibitory systemK Omote
Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, Sapporo 060, Japan
Brain Res 814:194-8. 1998..These results suggest that the pain state produced by formalin-induced chemical and/or inflammatory nociception is under the modulation of the monoaminergic (noradrenergic and serotonergic) descending inhibitory system...
- Antidepressants increase glial cell line-derived neurotrophic factor production through monoamine-independent activation of protein tyrosine kinase and extracellular signal-regulated kinase in glial cellsKazue Hisaoka
Institute of Clinical Research, Kure Medical Center, 3 1 Aoyama, Kure 737 0023, Japan
J Pharmacol Exp Ther 321:148-57. 2007....
- Role of norepinephrine in depressionP L Delgado
Department of Psychiatry, University of Arizona Medical Center, Tucson, USA
J Clin Psychiatry 61:5-12. 2000..Research investigating the neurobiology of depression may be more informed if the focus is shifted to investigating areas of the brain modulated by monoamine systems rather than the monoamine systems themselves...
- From monoamines to genomic targets: a paradigm shift for drug discovery in depressionMa Li Wong
Center for Pharmacogenomics, Neuropsychiatric Institute and David Geffen School of Medicine at UCLA, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
Nat Rev Drug Discov 3:136-51. 2004..Yet such a drug is not on the horizon. Here, we cover the different phases of antidepressant drug discovery in the past, present and future, and comment on the challenges and opportunities for antidepressant research...
- Neuropharmacological profiles of antagonists of group II metabotropic glutamate receptorsNaoya Kawashima
Research Strategy Group, Pharmaceutical Business Division, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Kita ku, Saitama, Saitama 331 9530, Japan
Neurosci Lett 378:131-4. 2005..These findings suggest that modulation of serotonergic neuron might be, at least in part, responsible for the antidepressant-like effects of group II mGluR antagonists...
- Metabotropic glutamate receptors in the control of mood disordersJeffrey M Witkin
Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
CNS Neurol Disord Drug Targets 6:87-100. 2007....
- Behavioural analysis of the acute and chronic effects of MDMA treatment in the ratH M Marston
Fujisawa Institute of Neuroscience, Department of Pharmacology, University of Edinburgh, UK
Psychopharmacology (Berl) 144:67-76. 1999..The widespread recreational use of MDMA thus raises concerns over the long-term functional sequelae in humans...
- Correlates of sleep and waking in Drosophila melanogasterP J Shaw
The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
Science 287:1834-7. 2000..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
- Afferents to the ventrolateral preoptic nucleusThomas C Chou
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Neurosci 22:977-90. 2002..These robust pathways suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions...
- Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disordersDavid A Morilak
Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
Int J Neuropsychopharmacol 7:193-218. 2004....
- Antidepressants for the new millenniumP Skolnick
Neuroscience Discovery, Eli Lilly, Lilly Corporate Center, Indianapolis, IN 46285, USA
Eur J Pharmacol 375:31-40. 1999..The pathways leading to this convergence provide a rudimentary framework for discovering novel antidepressants...
- Tesofensine (NS 2330), a monoamine reuptake inhibitor, in patients with advanced Parkinson disease and motor fluctuations: the ADVANS StudyOlivier Rascol
Laboratoire de Pharmacologie Medicale et Clinique, Pole NeuroSciences, Centre d Investigations Cliniques, Institut National de la Sante et de la Recherche Medicale, Unité 825, University Hospital, Toulouse, France
Arch Neurol 65:577-83. 2008..To assess the safety and efficacy of tesofensine, a triple monoamine reuptake inhibitor, in patients with advanced Parkinson disease (PD)...
- Enhancement of antidepressant potency by a potentiator of AMPA receptorsXia Li
Neuroscience Discovery Research, Eli Lilly and Co, Lilly Research Laboratories, Corporate Center, Indianapolis, Indiana, USA
Cell Mol Neurobiol 23:419-30. 2003....
- Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseasesDiego J Walther
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
FEBS J 278:4740-55. 2011..Furthermore, the potential regulatory roles of protein monoaminylation in small GTPase, heterotrimeric G-protein and lipid signaling, as well as in modulating metabolic enzymes and nuclear processes, are critically assessed...
- The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nucleiM J Nirenberg
Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA
Proc Natl Acad Sci U S A 92:8773-7. 1995..The results provide direct evidence that a single VMAT is expressed in two morphologically distinct types of regulated secretory vesicles in central monoaminergic neurons...
- A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in miceIsabel Escobedo
Departamento Farmacologia, Facultad Medicina, Universidad Complutense, 28040 Madrid, Spain
Br J Pharmacol 144:231-41. 2005..6. The fact that the acute changes induced by i.p. or intrastriatal HHMA administration differed indicates that HHMA is metabolised to other compounds which are responsible for changes observed after i.p. administration...
- Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuseMichael T Williams
Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
Neuropsychopharmacology 32:1404-20. 2007..5-MEO-DIPT may have the potential to induce untoward effects in humans...
- Stimulant and reinforcing effects of cocaine in monoamine transporter knockout miceBeatriz A Rocha
Merck Research Laboratories, Department of Pharmacology, RY80Y 140, PO Box 2000, Rahway, NJ 07065, USA
Eur J Pharmacol 479:107-15. 2003..Overall, these studies provide evidence that cocaine dynamically acts at multiple sites through pathways that might be exchangeable under certain circumstances...
- Effects of long-term hormone treatment and of tibolone on monoamines and monoamine metabolites in the brains of ovariectomised, Cynomologous monkeysR B Gibbs
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, PA 15261, USA
J Neuroendocrinol 18:643-54. 2006....
- Effects of chronic variate stress on feeding behavior and on monoamine levels in different rat brain structuresG D Gamaro
Departamento de Bioquimica, Institute de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Brazil
Neurochem Int 42:107-14. 2003..Increased dopamine metabolite levels in the cortex and hippocampus were also observed and some of these modifications may be related to alterations in feeding behavior...
- Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the ratJean Christophe Cassel
Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521, CNRS Université Louis Pasteur, GDR 2905 CNRS, IFR 37 Neurosciences, 12 rue Goethe, F 67000 Strasbourg, France
Neuropsychopharmacology 30:1870-82. 2005..Thus, it is likely that the psycho(patho)logical problems reported by ecstasy users drinking alcohol are not solely due to the consumption of MDMA...
- Pineal melatonin and brain transmitter monoamines in CBA mice during chronic oral nicotine administrationHelena Gäddnäs
Department of Pharmacy, PO Box 56, Viikinkaari 5, FIN 00014, University of Helsinki, Finland
Brain Res 957:76-83. 2002..However, the results indicate that nicotinic receptors might be involved in the regulation of pineal function...
- Brain angiotensin and anxiety-related behavior: the transgenic rat TGR(ASrAOGEN)680Jörg Peter Voigt
Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universitat Berlin, Berlin, Germany
Brain Res 1046:145-56. 2005..5-1 mg/kg IP) was more pronounced in TGR(ASrAOGEN)680. The data suggest an anxious phenotype in rats with low brain angiotensinogen, possibly related to secondary dysfunctions of the brain serotonergic system...
- Effects of chronic cocaine on monoamine levels in discrete brain structures of lactating rat damsD A Lubin
Department of Psychiatry, University of North Carolina at Chapel Hill, 436 Taylor Hall, CB 7096, Chapel Hill, NC 27599 7096, USA
Pharmacol Biochem Behav 74:449-54. 2003..These dams also exhibited higher frequencies of defensive behavior toward an inanimate object compared to saline-treated controls. Potential mechanisms mediating cocaine-induced increases in responding are proposed...
- Influence of time of day on hypothalamic monoaminergic activity in early pregnancy: effect of a previous reproductive experienceLucia H Sider
Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Cidade Universitaria, Brazil
Psychoneuroendocrinology 28:195-206. 2003..These results suggest that a previous reproductive experience induces central functional changes during pregnancy which are expressed differently according to the time of day...
- Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatmentRiina Häidkind
Department of Psychology, University of Tartu, Tiigi 78, 50410 Tartu, Estonia
Neurochem Int 45:721-32. 2004....
- Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoaminesA Gonzalez-Quevedo
Instituto de Neurologia y Neurocirugia, Ciudad de La Habana, Cuba
Nutr Neurosci 6:253-61. 2003..On the other hand, in the hippocampus, Asp metabolism could be affected by Tau depletion with beta-Ala...
- Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortexZul Merali
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
Neuropsychopharmacology 29:1409-18. 2004..The activity of DA and 5-HT neurons, in contrast, is more closely aligned with the cognitive appraisal of predictor stimuli...
- [Effect of vitamin E on memory and brain monoaminergic neurotransmitter in chronic episodic hypoxia rat]Yan Xu
Department of Neurology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:333-6. 2003..To investigate the effect of Vitamin E (VitE) on memory and brain monoaminergic neurotransmitter level in chronic episodic hypoxia (EHYP) rat...
- Monoamine metabolism changes following the mouse forced swimming test but not the tail suspension testCaroline E Renard
EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
Fundam Clin Pharmacol 17:449-55. 2003..The same effect was observed after a TST of 8 min and onwards. This study confirms the fact that although these two tests are used to study depression, they involve different neuronal mechanisms...
- Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in ratsSusanne Koch
Lilly Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
Neuropharmacology 45:935-44. 2003..Chlorimipramine, duloxetine, and high dose venlafaxine acted as dual transporter inhibitors in rat PFC and increased extracellular concentrations of the monoamines, indicating functional dual transporter inhibition...
- [Effects of fluoxetine and its complexes with glycyrrizhinic acid on behavior and brain monoamine levels in rats]G T Shishkina
Zh Vyssh Nerv Deiat Im I P Pavlova 55:207-12. 2005....
- Effect of milnacipran on extracellular monoamine concentrations in the medial prefrontal cortex of rats pre-treated with lithiumYuji Kitaichi
Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
Eur J Pharmacol 516:219-26. 2005..Thus, lithium might augment the antidepressant effects of serotonin-noradrenaline reuptake inhibitors by augmenting serotonin release...
- Investigating the effects of distracting stimuli on nociceptive behaviour and associated alterations in brain monoamines in ratsGemma K Ford
Department of Pharmacology and Therapeutics, National University of Ireland, Galway, University Road, Galway, Ireland
Eur J Pain 12:970-9. 2008..These results indicate that exposure to a novel object or arena reduces nociceptive behaviour in rats, effects accompanied by discrete alterations in serotonin and dopamine metabolites in the medial prefrontal cortex...
- The effect of 1-(4,5-dihydro-1H-imidazol-2-yl) isoquinoline on monoamine release and turnover in the rat frontal cortexHaya Abu Ghazaleh
Psychopharmacology Unit, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
Neurosci Lett 422:109-13. 2007..In addition, BU98008 did not appear to affect serotonergic neurotransmission in the frontal cortex. In conclusion, the present study demonstrates that BU98008 shares some functional similarities with known selective I(2)-BS ligands...
- Dehydroepiandrosterone and monoamines in the limbic system of a genetic animal model of childhood depressionO Malkesman
Interdisciplinary Program in the Brain Sciences, Bar Ilan University, Israel
Eur Neuropsychopharmacol 18:255-61. 2008..The results from the current study may imply that treatment with DHEA could be a promising novel therapeutic option for depressed children and adolescents that fail to respond to common (monoaminergic) antidepressant treatments...
- Effects of oseltamivir phosphate (Tamiflu) and its metabolite (GS4071) on monoamine neurotransmission in the rat brainKanako Satoh
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, Shinjuku ku, Tokyo 169 0073, Japan
Biol Pharm Bull 30:1816-8. 2007..Neither Tamiflu nor GS4071 influenced the re-uptake/release of the 3 monoamines or GTP binding in postsynapses...
- Pharmaceutical agents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain monoaminesPetros N Karamanakos
Department of Pharmacology, Medical School, University of Ioannina, Ioannina, Greece
Int J Toxicol 26:423-32. 2007..Therefore, the ethanol intolerance produced by these agents, either aldehyde dehydrogenase is inhibited or not, could be the result of a "toxic serotonin syndrome," as in the case of the concomitant use of serotonin-active medications...
- Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic backgroundJudith A Siuciak
Neuroscience, Pfizer Global Research and Development, Groton, CT, USA
Neuropharmacology 54:417-27. 2008..Furthermore, the effects on the dopaminergic system appear to be background-dependent, with significant effects observed only in knockout mice on the C57BL6N genetic background...
- Long-term monoamine changes in the striatum and nucleus accumbens after acute chlorpyrifos exposureMargarita Moreno
Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almeria, Crta Sacramento s n, 04120 La Cañada de San Urbano, Almeria 04120, Spain
Toxicol Lett 176:162-7. 2008..The lack of correlation between regional AChE activity and neurochemical outcomes points to independent mechanisms...
- Effect of co-administration of a serotonin-noradrenaline reuptake inhibitor and a dopamine agonist on extracellular monoamine concentrations in ratsYuji Kitaichi
Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
Eur J Pharmacol 584:285-90. 2008....
- CNS depressive role of aqueous extract of Spinacia oleracea L. leaves in adult male albino ratsSutapa Das
S N Pradhan Centre for Neursciences, University of Calcutta, Kolkata, India
Indian J Exp Biol 46:185-90. 2008..Result suggests that SO exerts its CNS depressive effect in PTZ induced seizure by modulating the monoamines in different brain areas...
- [Toxicity of an alkaloid extracted from the plant Lobelia inflata: association with methamphetamine-induced behavioral abnormalities]Junichi Kitanaka
Chudoku Kenkyu 21:189-91. 2008
- Differential effects of adjunctive methylphenidate and citalopram on extracellular levels of serotonin, noradrenaline and dopamine in the rat brainPia Weikop
Neurosearch A S, 93 Pederstrupvej, DK 2750 Ballerup, Denmark
Eur Neuropsychopharmacol 17:658-71. 2007....
- The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brainFumiko Nagai
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, 24 1 Hyakunin cho 3 chome, Shinjuku ku, Tokyo, 169 0073 Japan
Eur J Pharmacol 559:132-7. 2007..The results suggest that some designer drugs strongly act on the central nerve system to the same extent as restricted drugs...
- Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouseShuhei Ide
Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8521, Japan
Neurosci Lett 386:14-7. 2005..This result suggested that the absence of Mecp2 does not impair the neurogenesis of monoaminergic and serotonergic neurons but causes succeeding impairment of those neuronal systems from 14 postnatal days...
- [The influence of chronic neurotization on the monoaminergic systems of various brain structures in rats with various typological characteristics]V N Chumakov
Zh Vyssh Nerv Deiat Im I P Pavlova 55:410-7. 2005..The results show a correlation between the typological of behavioral characteristics and the reaction to stress of monoaminergic systems of the hypothalamus, hippocampus, frontal cortex and amygdala...
- Effect of lamotrigine on the activities of monoamine oxidases A and B in vitro and on monoamine disposition in vivoEric Southam
Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park North, Harlow, Essex, CM19 5AW, UK
Eur J Pharmacol 519:237-45. 2005..Thus, altered monoamine metabolism in vivo is unlikely to account for the antidepressant action of the drug in bipolar depression...
- Neural monoaminergic mediation of the effect of St. John's wort extract on prepulse inhibition of the acoustic startle response in ratsAmani E Khalifa
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
J Psychopharmacol 19:467-72. 2005..Clinical investigations are therefore needed to determine whether St. John's wort extract may affect sensorimotor gating in both schizophrenia and Huntington's disease...
- Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in ratsRachel Maayan
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petah Tikva, Israel
Eur Neuropsychopharmacol 16:329-39. 2006..Such anti-craving activity is further enhanced by DHEA treatment before and during cocaine self-administration...
- Chronic ingestion of uranyl nitrate perturbs acetylcholinesterase activity and monoamine metabolism in male rat brainC Bussy
Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, BP166, 26702 Pierrelatte Cedex, France
Neurotoxicology 27:245-52. 2006....
- Both long and brief maternal separation produces persistent changes in tissue levels of brain monoamines in middle-aged female ratsL Arborelius
Department of Neuroscience, Section for Behavioural Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
Neuroscience 145:738-50. 2007..In addition, BMS affected brain monoaminergic levels mainly in the amygdala...
- Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized ratsJantarima Pandaranandaka
Interdepartment of Physiology, Graduate School, Chulalongkorn University, Henri Dunant Road, Bangkok 10330, Thailand
Physiol Behav 87:828-35. 2006..From these data, we concluded that, in fact, there is a relationship between estrogen and monoamines (i.e. serotonin, dopamine) in modulating the anxiety-like behaviors in female rats...
- Effect of morphine on locomotor activity and striatal monoamine metabolism in nicotine-withdrawn miceTanja Vihavainen
Division of Pharmacology and Toxicology, Faculty of Pharmacy, P O Box 56 Viikinkaari 5 E, University of Helsinki, FIN 00014 Helsinki, Finland
Behav Brain Res 173:85-93. 2006..Thus, the enhancement of morphine-induced locomotor activation in the nicotine-withdrawn mice could be related to nicotine-induced changes in the regulation of the nigrostriatal dopaminergic and serotonergic systems...
- Maternal factors and monoamine changes in stress-resilient and susceptible mice: cross-fostering effectsPriya Prakash
Institute of Neuroscience, Carleton University, Life Science Research Bldg, Ottawa, Ontario, Canada
Brain Res 1111:122-33. 2006..Although monoamine variations were largely determined by genetic factors, maternal influences contributed to stressor-elicited neurochemical changes in some regions, particularly dopamine activation within the prefrontal cortex...
- Nicotine-induced monoamine neurotransmitter changes in the brain of young ratsE Shearman
Nathan Kline Institute, Orangeburg, NY 10962, USA
Brain Res Bull 76:626-39. 2008..Developmental changes in receptor composition and distribution involving several transmitter systems and other components such as neuropeptides are also likely to play a role...
- Simultaneous HPLC quantification of monoamines and metabolites in the blood-free rat cochleaMaria Angeles Vicente-Torres
Center for Cell Culture CAI and Department of Surgery II ORL, Medicine Faculty, University Complutense of Madrid, 28040 Madrid, Spain
J Neurosci Methods 119:31-6. 2002..The present methodology may constitute a useful strategy to analyze monoamine turnover in the cochlea and other peripheral sensory receptors...
- Analysis of monoamines, adenosine and GABA in tissues of the land snail Helix lucorum and lizard Agama stellio stellio during hibernationBasile Michaelidis
Laboratory of Animal Physiology, Department of Zoology, Faculty of Biology, School of Science, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece
J Exp Biol 205:1135-43. 2002....
- Vesicular transport regulates monoamine storage and release but is not essential for amphetamine actionE A Fon
Department of Neurology, UCSF School of Medicine, University of California, San Francisco 94143, USA
Neuron 19:1271-83. 1997....
- Sensitization to the neuroendocrine, central monoamine and behavioural effects of murine tumor necrosis factor-alpha: peripheral and central mechanismsS Hayley
Institute of Neuroscience, Life Science Research Building, Carleton University, Ottawa, Ontario K1S 5B6, Canada
Eur J Neurosci 15:1061-76. 2002..Moreover, it appears that mTNF-alpha promotes central neurochemical plasticity through independent central and peripheral mechanisms...
- [Effect of cross-fostering on catalepsy and the brain monoamine level in rat offspring prone to catalepsy and in the control strain]V G Kolpakov
Institute of Cytology and Genetics, Russian Acad. Sci, Siberian Branch, Russia, 630090, Novosibirsk, Pr. Lavrentyeva, 10
Ross Fiziol Zh Im I M Sechenova 87:918-25. 2001..The cross-fostering diminished interstrain differences in the NA level in cortex, striatum, and hypothalamus...
- Dramatic brain aminergic deficit in a genetic mouse model of phenylketonuriaS Puglisi-Allegra
Dipartimento di Psicologia, Universita La Sapienza, Rome, Italy
Neuroreport 11:1361-4. 2000..NE content and metabolism were reduced in pFC, Cg, AMY and HIP. Finally, significantly reduced DA content and metabolism was observed in pFC, NAc, CP and AMY. In pFC, NAc and CP there was also a marked reduction of DA release...
- Nitroglycerin-induced activation of monoaminergic transmission in the ratC Tassorelli
IRCCS Neurological Institute, C Mondino Foundation, Pavia, Italy
Cephalalgia 22:226-32. 2002..These data might therefore help to clarify the mechanisms underlying the delayed migraine attack observed in migraine sufferers after systemic administration of nitroglycerin...
- Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brainRichard B Rothman
Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, 5500 Nathan Shock Drive, 21224, Baltimore, MD, USA
Eur J Pharmacol 447:51-7. 2002..The collective findings suggest that phendimetrazine is a "prodrug" that is converted to the active metabolite phenmetrazine, a potent substrate for norepinephrine and dopamine transporters...
- Effects of acute and chronic reboxetine treatment on stress-induced monoamine efflux in the rat frontal cortexMichelle E Page
Department of Psychiatry, University of Pennsylvania, 538 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Neuropsychopharmacology 27:237-47. 2002..Taken together, these data support the view that the noradrenergic and dopaminergic systems are modified by reboxetine treatment and may be important factors in the mechanism of action of antidepressant compounds...
- Neurochemical measurements in the brains of mice infected with Trypanosoma brucei brucei (TREU 667)B Amole
Faculty of Health Sciences, University Obafemi Awolowo, Ile Ife, Nigeria
Ann Trop Med Parasitol 83:225-32. 1989..These data may form the basis for the neuropsychiatric abnormalities that are associated with this disease...
- Effects of hokoei-to (pugongying-tang), a Kampo formula, on monoamine content in brain regions and mitogenic activity of splenic lymphocytes in ovariectomized miceQ H Song
The Research Division, Oriental Medicine Research Center, The Kitasato Institute, Tokyo, Japan
Am J Chin Med 29:433-43. 2001..The mitogenic activity of lymphocytes in the spleen was reduced after ovariectomy; a suppression of this reduced activity was observed in the group given hokoei-to...
- Effects of acetaminophen on monoaminergic systems in the rat central nervous systemJ P Courade
UPSA Laboratoires (Bristol-Myers Squibb group, Paris La Defense, France
Naunyn Schmiedebergs Arch Pharmacol 364:534-7. 2001..These results indicate that acetaminophen affects central monoaminergic neurotransmission, thereby suggesting that monoamines (especially 5-HT) might participate in its analgesic action...
- Changes in endogenous monoamines in aged ratsJ J Lee
Department of General Surgery, Mackay Memorial Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
Clin Exp Pharmacol Physiol 28:285-9. 2001..4. These data suggest that ageing may alter endogenous monoamines in both the brain and peripheral tissues...
- The effect of sumatriptan on brain monoamines in ratsD D Mitsikostas
Laboratory of Experimental Pharmacology, Athens University, School of Medicine, Greece
Headache 36:29-31. 1996..No dose-dependent effect of the drug was found. This subcortical antidopaminergic and antiserotoninergic effect of sumatriptan may be involved in its antimigraine action...
- Effects of neonatal handling on basal and stress-induced monoamine levels in the male and female rat brainA Papaioannou
Laboratory of Biology Biochemistry, School of Health Sciences, University of Athens, Papadiamantopoulou 123, Athens, GR 11527, Greece
Neuroscience 114:195-206. 2002..Exposure to either short- or long-term stress in adult life results in sex-dependent changes in brain monoamines, which are affected by handling thus making coping more efficient and rendering the stressful stimulus less noxious...
- Postsynaptic 5-HT(1A) receptors mediate an increase in locomotor activity in the monoamine-depleted ratLaurence Mignon
Department of Pharmacology and Experimental Therapeutics, Loyola University, Stritch School of Medicine, Maywood, IL 60153, USA
Psychopharmacology (Berl) 163:85-94. 2002..However, the exact mechanism remains unclear...
- Sleep deprivation in the rat: XVIII. Regional brain levels of monoamines and their metabolitesB M Bergmann
Department of Psychiatry, University of Chicago, Illionis
Sleep 17:583-9. 1994..The most common outlying values were for TSC rats. Thus, these results failed to demonstrate sleep loss-induced regional changes in levels of major brain monoamines or their metabolites.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Carotid labyrinth of amphibiansTatsumi Kusakabe
Laboratory for Anatomy and Physiology, Department of Sport and Medical Science, Kokushikan University, Tokyo 206 8515, Japan
Microsc Res Tech 59:207-26. 2002..In fluorescence histochemistry, the glomus cells emit intense fluorescence for biogenic monoamines. In fine structure, the glomus cells are characterized by a number of dense-cored vesicles in their ..
- Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats)V D Petkov
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia
Gen Pharmacol 21:71-5. 1990..5. An attempt is made to explain some similarities and differences in the behavioral effects of the drugs tested (and those observed in other studies) by the changes they induce in brain biogenic monoamines.
- Memory effects of the new derivative of the p-chlorophenoxyacetic acid adafenoxate compared to the effects of some cognition-enhancing drugs in ratsV D Petkov
Institute of Physiology, Bulgarian Academy of Sciences, Sofia
Arzneimittelforschung 39:1133-6. 1989..other data previously obtained about the effects of the drugs tested and of other nootropic drugs on brain biogenic monoamines, it is suggested that induced changes in biogenic monoamines are responsible for the similarities and the ..
- Up-regulation of circulating hemocyte population in response to bacterial challenge is mediated by octopamine and 5-hydroxytryptamine via Rac1 signal in Spodoptera exiguaGeun Seob Kim
Department of Bioresource Sciences, Andong National University, Andong 760 749, Republic of Korea
J Insect Physiol 56:559-66. 2010..This study analyzed the effects of both biogenic monoamines on mediating up-regulation of circulating hemocyte population in response to bacterial challenge...
- [Mechanism of action of antidepressants and therapeutic perspectives]M Bourin
Laboratoire de Neuropharmacologie UPRES EAD MENRT, Institut de signalisation et d innovation thérapeutique IFR75, Faculte de Pharmacie, Universite Paris Sud, Chatenay Malabry, France
Therapie 57:385-96. 2002..Depression is due to a deficiency in one or other biogenic monoamines (serotonin, 5-HT; noradrenaline, NA; dopamine, DA)...
- Reduced folate transport to the CNS in female Rett patientsV T Ramaekers
Division of Pediatric Neurology, Department of Pediatrics, University Hospital Aachen, Germany
Neurology 61:506-15. 2003Previous CSF studies in Rett syndrome suggest reduced turnover of the biogenic monoamines serotonin and dopamine...
- Octopamine and 5-hydroxytryptamine mediate hemocytic phagocytosis and nodule formation via eicosanoids in the beet armyworm, Spodoptera exiguaGeun Seob Kim
Department of Bioresource Sciences, Andong National University, Andong 760 749, Korea
Arch Insect Biochem Physiol 70:162-76. 2009..exigua. These effects of biogenic monoamines on the immune mediation were expressed through eicosanoids because the inhibitory effects of both ..
- HPLC analysis of serotonin, tryptamine, tyramine, and the hydroxycinnamic acid amides of serotonin and tyramine in food vegetablesDalin Ly
Department of Biotechnology BK21 Program, Environmental Friendly Agricultural Research Center, Biotechnology Research Institute, Chonnam National University, Gwangju, Republic of Korea
J Med Food 11:385-9. 2008b>Biogenic monoamines such as serotonin, tryptamine, and tyramine function as neurotransmitters and mitogenic factors in animals and are involved in flowering, morphogenesis, and protection from and adaptation to environmental changes in ..
- Effects of the nootropic agents adafenoxate and meclofenoxate on brain biogenic monoamines in aged ratsS L Stancheva
Institute of Physiology, Bulgarian Academy of Sciences
Acta Physiol Pharmacol Bulg 14:14-21. 1988The effect of the nootropic agents meclofenoxate (Mf) and adafenoxate (Adf) on the content of biogenic monoamines in the frontal cerebral cortex, striatum, hypothalamus, and hippocampus of 22-month-old rats was studied...
- Monoamine oxidase in amphistomes and its role in worm motilityS M Abidi
Section of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh, 202 002
J Helminthol 74:283-8. 2000..amphistomes, further indicating the involvement of different forms of MAO in the oxidative deamination of biogenic monoamines which might be partly responsible for neuromuscular coordination in amphistomes...
- Psychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: a novel neurometabolic condition responding to folinic acid substitutionV T Ramaekers
Division of Paediatric Neurology, Department of Paediatrics, University Hospital Aachen, Aachen, Germany
Neuropediatrics 33:301-8. 2002..The folate receptor-1 (FR 1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5-MTHF)...
- Biogenic amines, metabolites and monoamine oxidase in the filarial worm Setaria cerviA Agarwal
Division of Biochemistry, Central Drug Research Institute, Lucknow, India
Int J Parasitol 20:873-81. 1990Analysis of biogenic monoamines and their metabolites in Setaria cervi adults by reverse phase high performance liquid chromatography (HPLC) revealed dopamine as the major monoamine followed by norepinephrine and 5-hydroxytryptamine (5-..
- The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the level of brain biogenic monoamines in rats with angiotensin II-induced increase of water intakeS Stancheva
Radioisotope Laboratory, Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
Methods Find Exp Clin Pharmacol 24:287-90. 2002..II (Ang II)-receptor antagonists (losartan, EXP-3174, saralasin and sarmesin) on the levels of the biogenic monoamines dopamine, noradrenaline and serotonin in the frontal cortex, striatum, hypothalamus and hippocampus of rats ..
- Involvement of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine in Wistar rats: implication of postsynaptic 5-HT1A receptorsPetros N Karamanakos
Department of Pharmacology, Medical School, University of Ioannina, University Campus, 45110 Ioannina, Greece
Behav Brain Res 148:199-208. 2004..investigate the influence of CPA on the locomotor activity of the rat in relation to its effects on brain biogenic monoamines. Wistar rats were given CPA (40 mg/kg, i.p.) and locomotor activity was measured in a photocell cage...
- Early postnatal effects of prenatal exposure to glucocorticoids on testosterone metabolism and biogenic monoamines in discrete neuroendocrine regions of the rat brainA G Reznikov
Department of Endocrinology of Reproduction and Adaptation, VP Komissarenko Institute of Endocrinology and Metabolism, 69, Vyshgorodskaya St, Kiev 04114, Ukraine
Comp Biochem Physiol C Toxicol Pharmacol 138:169-75. 2004....
- Effects of chronic diazepam and medazepam treatment on the level of biogenic monoamines in different rat brain areasS Stancheva
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia
Acta Physiol Pharmacol Bulg 14:26-31. 1988..kg-1, i.p.) and medazepam (5 mg.kg-1, i.p.) on the level of biogenic monoamines in different rat brain areas: cerebral cortex, striatum, hippocampus, and hypothalamus...
- Comparative studies on the central effects of the angiotensin II analogue (Sar1 azaVal3 Ile8) AT IIV P Georgiev
Institute of Physiology, Bulgarian Academy of Sciences, Sofia
Acta Physiol Pharmacol Bulg 14:22-9. 1988..AT II, using intracerebroventricular administration, with respect to the following parameters: the level of biogenic monoamines (DA, NA and 5-HT) and the metabolites HVA and 5-HIAA in mouse forebrain; the behaviour of the animals--..
- Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1M Essand
Division of Clinical Immunology, Uppsala University, Sweden
J Mol Endocrinol 35:489-501. 2005..in the membrane of secretory vesicles of neuroendocrine and endocrine cells that allows the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles...
- A transporter for phenolamine uptake in the arthropod CNSB Cameron Donly
Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, London, Ontario, Canada
Arch Insect Biochem Physiol 59:172-83. 2005b>Biogenic monoamines play central roles in the nervous control of physiological processes in both vertebrates and invertebrates, each using a suite of neurotransmitters tailored through evolution...
- GENETIC AND BIOCHEMICAL DISSECTION OF PROLACTIN ACTIONSNELSON HORSEMAN; Fiscal Year: 2006..These discoveries imply that biogenic monoamines (esp. 5-HT) are important mammary-derived signaling molecules...
- SLEEP DEPRIVATION AND 5-HT AUTOREGULATORY PROCESSESRUSSELL POLAND; Fiscal Year: 2005..to supplement his background in electrophysiology with techniques in neurochemistry (microdialysis of biogenic monoamines in behaving animals and high performance liquid chromatography) and molecular biology, which he plans to ..
- ELECTROCHEMISTRY-EPR OF BIOLOGICAL ELECTRON TRANSFERRalph Adams; Fiscal Year: 1992This research is of a twofold nature--to study both the static and dynamic properties of the biogenic monoamines. Detailed three-dimensional maps of the concentrations of norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT) and ..
- COCAINE: A STUDY OF THE BIOCHEMICAL MECHANISM OF ACTIONFrank Carroll; Fiscal Year: 2007..abstract_text> ..
- MONOAMINERGIC CONTROL OF SPINAL INTERNEURONSCHARLES HECKMAN; Fiscal Year: 2004..These studies are likely to lead to novel pharmacological strategies to help restore normal function in spinal cord injury and stroke. ..
- Increased persistent sodium current in SOD1 motoneuronsCHARLES HECKMAN; Fiscal Year: 2009..These studies will play an essential role in determining if NaP makes an important contribution to motoneuron degeneration in ALS. Moreover, the results may prove invaluable in establishing new therapeutic strategies ..
- NOVEL PHARMACOTHERAPIES FOR COCAINE DEPENDENCEFrank Carroll; Fiscal Year: 2001..An ideal candidate compound would not only have efficacy in the preclinical models but would be safe, orally active, and potent, would not show tolerance or sensitization, and if abusable, would be less so than cocaine. ..
- Design and Development of Pharmacotherapies for Treating Stimulant AbuseFrank Ivy Carroll; Fiscal Year: 2010..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
- NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTIONFrank Carroll; Fiscal Year: 2008..abstract_text> ..
- Conference on the Diagnosis of Multiple System AtrophySid Gilman; Fiscal Year: 2006..This conference will assist with early diagnosis by developing new guidelines for diagnosis using newly available imaging and neuropathological criteria. [unreadable] [unreadable] [unreadable]..
- MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITYTheodore Slotkin; Fiscal Year: 2004..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
- Fetal & Adolescent Nicotine Effects on CNS 5HT SystemsTheodore Slotkin; Fiscal Year: 2003..abstract_text> ..
- DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEMTheodore Slotkin; Fiscal Year: 2003....
- IRON DEFICIENCY AND DOPAMINEJohn Beard; Fiscal Year: 2004..This expansion of study to other neurotransmitters will significantly contribute to our knowledge of the effects of iron deficiency on brain functioning in early life. ..
- Evaluating Striatal Function in a Murine HD ModelRoger Albin; Fiscal Year: 2007..Validation of these methods will provide new and useful behavioral tools for evaluating murine disease models. [unreadable] [unreadable] [unreadable]..
- DIENCEPHALIC MECHANISMS OF DRUG ABUSESTANLEY GLICK; Fiscal Year: 2008..The work proposed here may ultimately result in new kinds of treatments for drug abuse. ..
- Age at First Sex, Genes, Religion, and Other Social and Demographic ContextGuang Guo; Fiscal Year: 2007....
- Arousal and Attention in Cocaine-Exposed ChildrenLinda Mayes; Fiscal Year: 2007..Such interactions place cocaine-exposed children at higher risk for externalizing forms of psychopathology. ..
- Transdermal Nicotine Treatment of MCIPaul Newhouse; Fiscal Year: 2007..If nicotine proves successful in alleviating cognitive symptoms and in improving global outcomes along with reasonable safety, we will propose a large multicenter clinical trial. ..
- Adolescence: A Sensitive Period for Nicotine AddictionEdward Levin; Fiscal Year: 2008..unreadable] [unreadable]..
- Lateral Hypothalamus, Dopamine and Ingestive BehaviorDavid Wirtshafter; Fiscal Year: 2007..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
- Homer proteins, glutamate and alcoholismKAREN SZUMLINSKI; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- mGluR-Homer interactions in excessive drinkingKAREN SZUMLINSKI; Fiscal Year: 2008..abstract_text> ..
- PSYCHOBIOLOGY OF CORTICOTROPIN-RELEASING FACTORMichael Owens; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- REGULATION OF SEROTONIN TRANSPORTERSRandy D Blakely; Fiscal Year: 2010....
- Transgenic Mouse Model to Address Heterogeneity in Autism Spectrum DisordersRANDY DEAN BLAKELY; Fiscal Year: 2010..Based on exciting preliminary evidence that mice expressing Ala56 SERT exhibit multiple behavioral and biochemical phenotypes, we propose a two-year project to extend our studies and dissect the impact of SERT hyperfunction in vivo. ..
- Functional effects of mGluR potentiators in the CNSP Jeffrey Conn; Fiscal Year: 2010....
- Effect of Biomechanical Force Exposure on Cognition & Brain Activation in StudentThomas McAllister; Fiscal Year: 2009..Impact parameters will be directly measured using helmet-based accelerometer units. ..
- Estrogen Effects on Cholinergic Function in Older WomenPaul Newhouse; Fiscal Year: 2008..abstract_text> ..
- NICOTINE ADDICTION IN MICE LACKING THE NEURONAL NACHRMARINA PICCIOTTO; Fiscal Year: 2009..We propose that this mouse model may have implications for the development of psychiatric disorders in subjects exposed to nicotine in utero. ..
- Cocaine-Exposed Children & ERP Studies of NeurocognitionLinda Mayes; Fiscal Year: 2008..Such information may then lead to better definition and treatment of these developmental problems. ..
- Antidepressants - same effect on mesolimbic DA activity?JAY WEISS; Fiscal Year: 2009....
- PB-Environmental Stress Interactions: Re-evaluating RiskDeborah Cory Slechta; Fiscal Year: 2009..If Pb alters corticosterone and stress responsiveness, it could also modulate susceptibility to disease and dysfunction. ..
- SOY, LIFE STAGE, STRESS AND ATHEROSCLEROSIS IN FEMALESJAY KAPLAN; Fiscal Year: 2009....
- Modular Abnormalities of Brain Organization in AutismManuel Casanova; Fiscal Year: 2007..Treatment modalities, especially neuropharmaceutical agents, will prove more specific as their targets are better understood. ..
- STEROID HORMONES--BRAIN AND BEHAVIORANNE ETGEN; Fiscal Year: 2007..These studies will provide novel[unreadable] insights into the cellular and molecular mechanisms by which ovarian[unreadable] sterioids act in the brain and to produce predictable behavioral[unreadable] changes. ..
- mGluR4 Potentiators as a Treatment for Parkinson's DiseaseP Conn; Fiscal Year: 2007..This high throughput screen will provide the basis for future studies aimed at developing allosteric potentiators of mGluR4 that are suitable for clinical testing. [unreadable] [unreadable]..
- Throughput Assay:Allosteric Potentiator of GluR (RMI)P Conn; Fiscal Year: 2004..This will provide the characterization needed to allow us to optimize this assay for use in future screens of larger compound libraries. ..
- BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSIONDavid Wirtshafter; Fiscal Year: 2003..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
- Reduced Interneuronal Space in Schizophrenic BrainsManuel Casanova; Fiscal Year: 2005..If our preliminary findings are corroborated, the smaller than normal minicolumns will demonstrate a reorganization of brain circuitry most probably defined during development. ..
- AROUSAL REGULATORY FUNCTIONS IN COCAINE-EXPOSED CHILDRENLinda Mayes; Fiscal Year: 2004..Early disruption of the developmental ontogeny of arousal and attentional regulatory capacities may have effects that extend well into the school-aged years and alter the normal trajectory of cognitive and social-emotional development. ..
- New Perspectives in Transporter Biology-FASEB conferenceRobert Edwards; Fiscal Year: 2003..Each oral session will be followed by a panel discussion of the topic. To promote the advancement of junior faculty, the most exciting poster submissions will be selected for short oral presentations during the regular oral sessions. ..
- A Neurogenomic Model for Dopamine Transporter RegulationRandy Blakely; Fiscal Year: 2002..elegans DAT (CeDAT) expression in cultured DA neurons and 2) to develop a system where a combination of transgenic and proteomic approaches can be applied to permit the evaluation of hypothesized and novel DAT regulators. ..
- CORTICOLIMBIC SYSTEM AND SCHIZOPHRENIAFrancine Benes; Fiscal Year: 2002....
- Behavioral Genetics and Toxic ResponseEdward Levin; Fiscal Year: 2002....
- CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL ATheoharis Theoharides; Fiscal Year: 2001..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
- Controllability of Stress--Effects on Tumor DevelopmentJAY WEISS; Fiscal Year: 2004..Finally, these approaches will be combined by assessing how control vs. non-control affects lymphocyte-tumor cell interaction assessed by histological analysis. ..
- NEUROBEHAVIORAL MECHANISMS OF DRUG ADDICTIONSTANLEY GLICK; Fiscal Year: 2001..This research may result in novel treatments for addictive disorders in humans. ..
- RUPP-PIChristopher McDougle; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] ..
- GENETIC ANALYSIS OF DOPAMINERGIC REWARD MECHANISMSMarc Caron; Fiscal Year: 2005..This should allow identification of genes involved in stable alterations of the CNS associated with chronic drug exposure. ..
- DOPAMINE TRANSPORTER AGENTS AGAINST COCAINE DEPENDENCEALOKE DUTTA; Fiscal Year: 2007..Compounds selected based on their in vitro activity will be tested for effects on locomotor activity and drug discrimination and self-administration studies to assess their potential in replacement therapy. ..
- Social Information Processing: Assessment DevelopmentEMIL COCCARO; Fiscal Year: 2007..Development of such measures is critical for the further scientific study of SIP and for its integration in neurobiologhical research. [unreadable] [unreadable]..
- Nicotinic-Antipsychotic Drug Interactions and CognitionEdward Levin; Fiscal Year: 2006..abstract_text> ..
- NEUROENDOCRINE BASES OF REPRODUCTIVE BEHAVIORANNE ETGEN; Fiscal Year: 2006..Specific Aim 4 will determine how IGF-1 acutely potentiates a1-adrenoceptor signaling in the HYP-POA of E2-treated females and whether this is important for reproductive behavior. ..
- TRANSPORT OF NEUROTRANSMITTERS INTO SYNAPTIC VESICLESRobert Edwards; Fiscal Year: 2005..Third, we will manipulate the expression, localization and regulation of the transporters in vivo to assess the role of these mechanisms in synaptic transmission and behavior. ..
- Dopamine Receptors: Characterization and RegulationMarc Caron; Fiscal Year: 2007..abstract_text> ..
- Environmental Risk Factors and Canine Malignant LymphomaElizabeth Bertone Johnson; Fiscal Year: 2005..Because dogs and their human owners share a common environment within the household, results from this study will have direct relevance to the on-going effort to identify factors that may increase risk of human NHL. ..
- Novel Pharmacological Strategies in AutismChristopher McDougle; Fiscal Year: 2009..Phase II (following 6 months of aripiprazole monotherapy). ..
- Evoked potentials and vulnerability to ketamine in mice.Steven Siegel; Fiscal Year: 2004..abstract_text> ..
- Effects of self-administered MDMA on brain and behavior in rhesus monkeysWilliam Fantegrossi; Fiscal Year: 2007..Thus, these studies are likely to be more relevant to the potential human condition of MDMA-induced lasting neurochemical alterations and behavioral changes [unreadable] [unreadable]..
- Paradoxical Antidepressant Action in Locus Coeruleus during DevelopmentJAY WEISS; Fiscal Year: 2009....
- Restraint stress-induced neurogenic bladder inflammationTheoharis Theoharides; Fiscal Year: 2006..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
- Methamphetamine, procedural learning, and plasticityDAVID DABERKOW; Fiscal Year: 2005..abstract_text> ..