biogenic monoamines

Summary

Summary: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.

Top Publications

  1. ncbi New approaches to antidepressant drug discovery: beyond monoamines
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Rev Neurosci 7:137-51. 2006
  2. ncbi A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition
    Lucas Lecourtier
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Neurosci Biobehav Rev 31:658-72. 2007
  3. ncbi Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    J Pharmacol Exp Ther 334:1059-65. 2010
  4. ncbi Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio)
    J Kaslin
    Department of Biology, Abo Akademi University, BioCity, FIN-20520 Turku/Abo, Finland
    J Comp Neurol 440:342-77. 2001
  5. ncbi The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys
    Diane T Stephenson
    Pfizer Global Research and Development, Groton, CT 06340, USA
    J Pharmacol Exp Ther 314:1257-66. 2005
  6. ncbi Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies
    H G Ruhé
    Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Psychiatry 12:331-59. 2007
  7. ncbi Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes
    Damijana Mojca Juric
    Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Korytkova 2, SI 1000 Ljubljana, Slovenia
    Brain Res 1108:54-62. 2006
  8. ncbi Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats
    Bea J van der Vegt
    Department of Animal Physiology, Biology, University of Groningen, Haren, The Netherlands
    Horm Behav 44:199-208. 2003
  9. ncbi A matter of focus: monoaminergic modulation of stimulus coding in mammalian sensory networks
    L M Hurley
    1001 East Third Street, Jordan Hall Biology Department, Indiana University, Bloomington, Indiana 47405, USA
    Curr Opin Neurobiol 14:488-95. 2004
  10. ncbi Formalin-induced nociception activates a monoaminergic descending inhibitory system
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, Sapporo 060, Japan
    Brain Res 814:194-8. 1998

Detail Information

Publications223 found, 100 shown here

  1. ncbi New approaches to antidepressant drug discovery: beyond monoamines
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Rev Neurosci 7:137-51. 2006
    ..This review summarizes the obstacles that have hindered the development of non-monoamine-based antidepressants, and provides a progress report on some of the most promising current strategies...
  2. ncbi A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition
    Lucas Lecourtier
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Neurosci Biobehav Rev 31:658-72. 2007
    ..Electrophysiological studies indicate a role in metaplasticity, the modulation of neuroplasticity. These studies thus reveal important roles of the habenular complex in learning, memory and attention...
  3. ncbi Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    J Pharmacol Exp Ther 334:1059-65. 2010
    ..Combined administration of an SNRI with morphine might be a promising treatment to suppress postoperative hypersensitivity...
  4. ncbi Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio)
    J Kaslin
    Department of Biology, Abo Akademi University, BioCity, FIN-20520 Turku/Abo, Finland
    J Comp Neurol 440:342-77. 2001
    ..The results also provide evidence of homologies to mammalian systems and allow identification of several previously uncharacterized systems in zebrafish mutants...
  5. ncbi The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys
    Diane T Stephenson
    Pfizer Global Research and Development, Groton, CT 06340, USA
    J Pharmacol Exp Ther 314:1257-66. 2005
    ..These results suggest that sumanirole can exert antiparkinsonian effects similar to L-DOPA without the behavioral and morphological consequences of the latter...
  6. ncbi Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies
    H G Ruhé
    Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Psychiatry 12:331-59. 2007
    ..They presumably clarify a vulnerability trait to become depressed. Directions for further investigation of this vulnerability trait are proposed...
  7. ncbi Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes
    Damijana Mojca Juric
    Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Korytkova 2, SI 1000 Ljubljana, Slovenia
    Brain Res 1108:54-62. 2006
    ....
  8. ncbi Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats
    Bea J van der Vegt
    Department of Animal Physiology, Biology, University of Groningen, Haren, The Netherlands
    Horm Behav 44:199-208. 2003
    ..Interpretation of CSF metabolite levels in terms of activity of neural substrates requires a far more detailed knowledge of the dynamics and kinetics of a neurotransmitter after its release...
  9. ncbi A matter of focus: monoaminergic modulation of stimulus coding in mammalian sensory networks
    L M Hurley
    1001 East Third Street, Jordan Hall Biology Department, Indiana University, Bloomington, Indiana 47405, USA
    Curr Opin Neurobiol 14:488-95. 2004
    ....
  10. ncbi Formalin-induced nociception activates a monoaminergic descending inhibitory system
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, Sapporo 060, Japan
    Brain Res 814:194-8. 1998
    ..These results suggest that the pain state produced by formalin-induced chemical and/or inflammatory nociception is under the modulation of the monoaminergic (noradrenergic and serotonergic) descending inhibitory system...
  11. ncbi Antidepressants increase glial cell line-derived neurotrophic factor production through monoamine-independent activation of protein tyrosine kinase and extracellular signal-regulated kinase in glial cells
    Kazue Hisaoka
    Institute of Clinical Research, Kure Medical Center, 3 1 Aoyama, Kure 737 0023, Japan
    J Pharmacol Exp Ther 321:148-57. 2007
    ....
  12. ncbi Role of norepinephrine in depression
    P L Delgado
    Department of Psychiatry, University of Arizona Medical Center, Tucson, USA
    J Clin Psychiatry 61:5-12. 2000
    ..Research investigating the neurobiology of depression may be more informed if the focus is shifted to investigating areas of the brain modulated by monoamine systems rather than the monoamine systems themselves...
  13. ncbi From monoamines to genomic targets: a paradigm shift for drug discovery in depression
    Ma Li Wong
    Center for Pharmacogenomics, Neuropsychiatric Institute and David Geffen School of Medicine at UCLA, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
    Nat Rev Drug Discov 3:136-51. 2004
    ..Yet such a drug is not on the horizon. Here, we cover the different phases of antidepressant drug discovery in the past, present and future, and comment on the challenges and opportunities for antidepressant research...
  14. ncbi Neuropharmacological profiles of antagonists of group II metabotropic glutamate receptors
    Naoya Kawashima
    Research Strategy Group, Pharmaceutical Business Division, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Kita ku, Saitama, Saitama 331 9530, Japan
    Neurosci Lett 378:131-4. 2005
    ..These findings suggest that modulation of serotonergic neuron might be, at least in part, responsible for the antidepressant-like effects of group II mGluR antagonists...
  15. ncbi Metabotropic glutamate receptors in the control of mood disorders
    Jeffrey M Witkin
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    CNS Neurol Disord Drug Targets 6:87-100. 2007
    ....
  16. ncbi Behavioural analysis of the acute and chronic effects of MDMA treatment in the rat
    H M Marston
    Fujisawa Institute of Neuroscience, Department of Pharmacology, University of Edinburgh, UK
    Psychopharmacology (Berl) 144:67-76. 1999
    ..The widespread recreational use of MDMA thus raises concerns over the long-term functional sequelae in humans...
  17. ncbi Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000
    ..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
  18. ncbi Afferents to the ventrolateral preoptic nucleus
    Thomas C Chou
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:977-90. 2002
    ..These robust pathways suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions...
  19. ncbi Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders
    David A Morilak
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Int J Neuropsychopharmacol 7:193-218. 2004
    ....
  20. ncbi Antidepressants for the new millennium
    P Skolnick
    Neuroscience Discovery, Eli Lilly, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Eur J Pharmacol 375:31-40. 1999
    ..The pathways leading to this convergence provide a rudimentary framework for discovering novel antidepressants...
  21. ncbi Tesofensine (NS 2330), a monoamine reuptake inhibitor, in patients with advanced Parkinson disease and motor fluctuations: the ADVANS Study
    Olivier Rascol
    Laboratoire de Pharmacologie Medicale et Clinique, Pole NeuroSciences, Centre d Investigations Cliniques, Institut National de la Sante et de la Recherche Medicale, Unité 825, University Hospital, Toulouse, France
    Arch Neurol 65:577-83. 2008
    ..To assess the safety and efficacy of tesofensine, a triple monoamine reuptake inhibitor, in patients with advanced Parkinson disease (PD)...
  22. ncbi Enhancement of antidepressant potency by a potentiator of AMPA receptors
    Xia Li
    Neuroscience Discovery Research, Eli Lilly and Co, Lilly Research Laboratories, Corporate Center, Indianapolis, Indiana, USA
    Cell Mol Neurobiol 23:419-30. 2003
    ....
  23. ncbi Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseases
    Diego J Walther
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    FEBS J 278:4740-55. 2011
    ..Furthermore, the potential regulatory roles of protein monoaminylation in small GTPase, heterotrimeric G-protein and lipid signaling, as well as in modulating metabolic enzymes and nuclear processes, are critically assessed...
  24. pmc The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nuclei
    M J Nirenberg
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 92:8773-7. 1995
    ..The results provide direct evidence that a single VMAT is expressed in two morphologically distinct types of regulated secretory vesicles in central monoaminergic neurons...
  25. pmc A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice
    Isabel Escobedo
    Departamento Farmacologia, Facultad Medicina, Universidad Complutense, 28040 Madrid, Spain
    Br J Pharmacol 144:231-41. 2005
    ..6. The fact that the acute changes induced by i.p. or intrastriatal HHMA administration differed indicates that HHMA is metabolised to other compounds which are responsible for changes observed after i.p. administration...
  26. pmc Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse
    Michael T Williams
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
    Neuropsychopharmacology 32:1404-20. 2007
    ..5-MEO-DIPT may have the potential to induce untoward effects in humans...
  27. ncbi Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice
    Beatriz A Rocha
    Merck Research Laboratories, Department of Pharmacology, RY80Y 140, PO Box 2000, Rahway, NJ 07065, USA
    Eur J Pharmacol 479:107-15. 2003
    ..Overall, these studies provide evidence that cocaine dynamically acts at multiple sites through pathways that might be exchangeable under certain circumstances...
  28. ncbi Effects of long-term hormone treatment and of tibolone on monoamines and monoamine metabolites in the brains of ovariectomised, Cynomologous monkeys
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, PA 15261, USA
    J Neuroendocrinol 18:643-54. 2006
    ....
  29. ncbi Effects of chronic variate stress on feeding behavior and on monoamine levels in different rat brain structures
    G D Gamaro
    Departamento de Bioquimica, Institute de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Brazil
    Neurochem Int 42:107-14. 2003
    ..Increased dopamine metabolite levels in the cortex and hippocampus were also observed and some of these modifications may be related to alterations in feeding behavior...
  30. ncbi Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat
    Jean Christophe Cassel
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521, CNRS Université Louis Pasteur, GDR 2905 CNRS, IFR 37 Neurosciences, 12 rue Goethe, F 67000 Strasbourg, France
    Neuropsychopharmacology 30:1870-82. 2005
    ..Thus, it is likely that the psycho(patho)logical problems reported by ecstasy users drinking alcohol are not solely due to the consumption of MDMA...
  31. ncbi Pineal melatonin and brain transmitter monoamines in CBA mice during chronic oral nicotine administration
    Helena Gäddnäs
    Department of Pharmacy, PO Box 56, Viikinkaari 5, FIN 00014, University of Helsinki, Finland
    Brain Res 957:76-83. 2002
    ..However, the results indicate that nicotinic receptors might be involved in the regulation of pineal function...
  32. ncbi Brain angiotensin and anxiety-related behavior: the transgenic rat TGR(ASrAOGEN)680
    Jörg Peter Voigt
    Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universitat Berlin, Berlin, Germany
    Brain Res 1046:145-56. 2005
    ..5-1 mg/kg IP) was more pronounced in TGR(ASrAOGEN)680. The data suggest an anxious phenotype in rats with low brain angiotensinogen, possibly related to secondary dysfunctions of the brain serotonergic system...
  33. pmc Effects of chronic cocaine on monoamine levels in discrete brain structures of lactating rat dams
    D A Lubin
    Department of Psychiatry, University of North Carolina at Chapel Hill, 436 Taylor Hall, CB 7096, Chapel Hill, NC 27599 7096, USA
    Pharmacol Biochem Behav 74:449-54. 2003
    ..These dams also exhibited higher frequencies of defensive behavior toward an inanimate object compared to saline-treated controls. Potential mechanisms mediating cocaine-induced increases in responding are proposed...
  34. ncbi Influence of time of day on hypothalamic monoaminergic activity in early pregnancy: effect of a previous reproductive experience
    Lucia H Sider
    Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Cidade Universitaria, Brazil
    Psychoneuroendocrinology 28:195-206. 2003
    ..These results suggest that a previous reproductive experience induces central functional changes during pregnancy which are expressed differently according to the time of day...
  35. ncbi Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatment
    Riina Häidkind
    Department of Psychology, University of Tartu, Tiigi 78, 50410 Tartu, Estonia
    Neurochem Int 45:721-32. 2004
    ....
  36. ncbi Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoamines
    A Gonzalez-Quevedo
    Instituto de Neurologia y Neurocirugia, Ciudad de La Habana, Cuba
    Nutr Neurosci 6:253-61. 2003
    ..On the other hand, in the hippocampus, Asp metabolism could be affected by Tau depletion with beta-Ala...
  37. ncbi Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortex
    Zul Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Neuropsychopharmacology 29:1409-18. 2004
    ..The activity of DA and 5-HT neurons, in contrast, is more closely aligned with the cognitive appraisal of predictor stimuli...
  38. ncbi [Effect of vitamin E on memory and brain monoaminergic neurotransmitter in chronic episodic hypoxia rat]
    Yan Xu
    Department of Neurology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:333-6. 2003
    ..To investigate the effect of Vitamin E (VitE) on memory and brain monoaminergic neurotransmitter level in chronic episodic hypoxia (EHYP) rat...
  39. ncbi Monoamine metabolism changes following the mouse forced swimming test but not the tail suspension test
    Caroline E Renard
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Fundam Clin Pharmacol 17:449-55. 2003
    ..The same effect was observed after a TST of 8 min and onwards. This study confirms the fact that although these two tests are used to study depression, they involve different neuronal mechanisms...
  40. ncbi Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in rats
    Susanne Koch
    Lilly Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 45:935-44. 2003
    ..Chlorimipramine, duloxetine, and high dose venlafaxine acted as dual transporter inhibitors in rat PFC and increased extracellular concentrations of the monoamines, indicating functional dual transporter inhibition...
  41. ncbi [Effects of fluoxetine and its complexes with glycyrrizhinic acid on behavior and brain monoamine levels in rats]
    G T Shishkina
    Zh Vyssh Nerv Deiat Im I P Pavlova 55:207-12. 2005
    ....
  42. ncbi Effect of milnacipran on extracellular monoamine concentrations in the medial prefrontal cortex of rats pre-treated with lithium
    Yuji Kitaichi
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 516:219-26. 2005
    ..Thus, lithium might augment the antidepressant effects of serotonin-noradrenaline reuptake inhibitors by augmenting serotonin release...
  43. ncbi Investigating the effects of distracting stimuli on nociceptive behaviour and associated alterations in brain monoamines in rats
    Gemma K Ford
    Department of Pharmacology and Therapeutics, National University of Ireland, Galway, University Road, Galway, Ireland
    Eur J Pain 12:970-9. 2008
    ..These results indicate that exposure to a novel object or arena reduces nociceptive behaviour in rats, effects accompanied by discrete alterations in serotonin and dopamine metabolites in the medial prefrontal cortex...
  44. ncbi The effect of 1-(4,5-dihydro-1H-imidazol-2-yl) isoquinoline on monoamine release and turnover in the rat frontal cortex
    Haya Abu Ghazaleh
    Psychopharmacology Unit, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    Neurosci Lett 422:109-13. 2007
    ..In addition, BU98008 did not appear to affect serotonergic neurotransmission in the frontal cortex. In conclusion, the present study demonstrates that BU98008 shares some functional similarities with known selective I(2)-BS ligands...
  45. ncbi Dehydroepiandrosterone and monoamines in the limbic system of a genetic animal model of childhood depression
    O Malkesman
    Interdisciplinary Program in the Brain Sciences, Bar Ilan University, Israel
    Eur Neuropsychopharmacol 18:255-61. 2008
    ..The results from the current study may imply that treatment with DHEA could be a promising novel therapeutic option for depressed children and adolescents that fail to respond to common (monoaminergic) antidepressant treatments...
  46. ncbi Effects of oseltamivir phosphate (Tamiflu) and its metabolite (GS4071) on monoamine neurotransmission in the rat brain
    Kanako Satoh
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, Shinjuku ku, Tokyo 169 0073, Japan
    Biol Pharm Bull 30:1816-8. 2007
    ..Neither Tamiflu nor GS4071 influenced the re-uptake/release of the 3 monoamines or GTP binding in postsynapses...
  47. ncbi Pharmaceutical agents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain monoamines
    Petros N Karamanakos
    Department of Pharmacology, Medical School, University of Ioannina, Ioannina, Greece
    Int J Toxicol 26:423-32. 2007
    ..Therefore, the ethanol intolerance produced by these agents, either aldehyde dehydrogenase is inhibited or not, could be the result of a "toxic serotonin syndrome," as in the case of the concomitant use of serotonin-active medications...
  48. ncbi Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic background
    Judith A Siuciak
    Neuroscience, Pfizer Global Research and Development, Groton, CT, USA
    Neuropharmacology 54:417-27. 2008
    ..Furthermore, the effects on the dopaminergic system appear to be background-dependent, with significant effects observed only in knockout mice on the C57BL6N genetic background...
  49. ncbi Long-term monoamine changes in the striatum and nucleus accumbens after acute chlorpyrifos exposure
    Margarita Moreno
    Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almeria, Crta Sacramento s n, 04120 La Cañada de San Urbano, Almeria 04120, Spain
    Toxicol Lett 176:162-7. 2008
    ..The lack of correlation between regional AChE activity and neurochemical outcomes points to independent mechanisms...
  50. ncbi Effect of co-administration of a serotonin-noradrenaline reuptake inhibitor and a dopamine agonist on extracellular monoamine concentrations in rats
    Yuji Kitaichi
    Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Pharmacol 584:285-90. 2008
    ....
  51. ncbi CNS depressive role of aqueous extract of Spinacia oleracea L. leaves in adult male albino rats
    Sutapa Das
    S N Pradhan Centre for Neursciences, University of Calcutta, Kolkata, India
    Indian J Exp Biol 46:185-90. 2008
    ..Result suggests that SO exerts its CNS depressive effect in PTZ induced seizure by modulating the monoamines in different brain areas...
  52. ncbi [Toxicity of an alkaloid extracted from the plant Lobelia inflata: association with methamphetamine-induced behavioral abnormalities]
    Junichi Kitanaka
    Chudoku Kenkyu 21:189-91. 2008
  53. ncbi Differential effects of adjunctive methylphenidate and citalopram on extracellular levels of serotonin, noradrenaline and dopamine in the rat brain
    Pia Weikop
    Neurosearch A S, 93 Pederstrupvej, DK 2750 Ballerup, Denmark
    Eur Neuropsychopharmacol 17:658-71. 2007
    ....
  54. ncbi The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain
    Fumiko Nagai
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, 24 1 Hyakunin cho 3 chome, Shinjuku ku, Tokyo, 169 0073 Japan
    Eur J Pharmacol 559:132-7. 2007
    ..The results suggest that some designer drugs strongly act on the central nerve system to the same extent as restricted drugs...
  55. ncbi Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse
    Shuhei Ide
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8521, Japan
    Neurosci Lett 386:14-7. 2005
    ..This result suggested that the absence of Mecp2 does not impair the neurogenesis of monoaminergic and serotonergic neurons but causes succeeding impairment of those neuronal systems from 14 postnatal days...
  56. ncbi [The influence of chronic neurotization on the monoaminergic systems of various brain structures in rats with various typological characteristics]
    V N Chumakov
    Zh Vyssh Nerv Deiat Im I P Pavlova 55:410-7. 2005
    ..The results show a correlation between the typological of behavioral characteristics and the reaction to stress of monoaminergic systems of the hypothalamus, hippocampus, frontal cortex and amygdala...
  57. ncbi Effect of lamotrigine on the activities of monoamine oxidases A and B in vitro and on monoamine disposition in vivo
    Eric Southam
    Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park North, Harlow, Essex, CM19 5AW, UK
    Eur J Pharmacol 519:237-45. 2005
    ..Thus, altered monoamine metabolism in vivo is unlikely to account for the antidepressant action of the drug in bipolar depression...
  58. ncbi Neural monoaminergic mediation of the effect of St. John's wort extract on prepulse inhibition of the acoustic startle response in rats
    Amani E Khalifa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    J Psychopharmacol 19:467-72. 2005
    ..Clinical investigations are therefore needed to determine whether St. John's wort extract may affect sensorimotor gating in both schizophrenia and Huntington's disease...
  59. ncbi Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats
    Rachel Maayan
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petah Tikva, Israel
    Eur Neuropsychopharmacol 16:329-39. 2006
    ..Such anti-craving activity is further enhanced by DHEA treatment before and during cocaine self-administration...
  60. ncbi Chronic ingestion of uranyl nitrate perturbs acetylcholinesterase activity and monoamine metabolism in male rat brain
    C Bussy
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, BP166, 26702 Pierrelatte Cedex, France
    Neurotoxicology 27:245-52. 2006
    ....
  61. ncbi Both long and brief maternal separation produces persistent changes in tissue levels of brain monoamines in middle-aged female rats
    L Arborelius
    Department of Neuroscience, Section for Behavioural Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Neuroscience 145:738-50. 2007
    ..In addition, BMS affected brain monoaminergic levels mainly in the amygdala...
  62. ncbi Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats
    Jantarima Pandaranandaka
    Interdepartment of Physiology, Graduate School, Chulalongkorn University, Henri Dunant Road, Bangkok 10330, Thailand
    Physiol Behav 87:828-35. 2006
    ..From these data, we concluded that, in fact, there is a relationship between estrogen and monoamines (i.e. serotonin, dopamine) in modulating the anxiety-like behaviors in female rats...
  63. ncbi Effect of morphine on locomotor activity and striatal monoamine metabolism in nicotine-withdrawn mice
    Tanja Vihavainen
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, P O Box 56 Viikinkaari 5 E, University of Helsinki, FIN 00014 Helsinki, Finland
    Behav Brain Res 173:85-93. 2006
    ..Thus, the enhancement of morphine-induced locomotor activation in the nicotine-withdrawn mice could be related to nicotine-induced changes in the regulation of the nigrostriatal dopaminergic and serotonergic systems...
  64. ncbi Maternal factors and monoamine changes in stress-resilient and susceptible mice: cross-fostering effects
    Priya Prakash
    Institute of Neuroscience, Carleton University, Life Science Research Bldg, Ottawa, Ontario, Canada
    Brain Res 1111:122-33. 2006
    ..Although monoamine variations were largely determined by genetic factors, maternal influences contributed to stressor-elicited neurochemical changes in some regions, particularly dopamine activation within the prefrontal cortex...
  65. ncbi Nicotine-induced monoamine neurotransmitter changes in the brain of young rats
    E Shearman
    Nathan Kline Institute, Orangeburg, NY 10962, USA
    Brain Res Bull 76:626-39. 2008
    ..Developmental changes in receptor composition and distribution involving several transmitter systems and other components such as neuropeptides are also likely to play a role...
  66. ncbi Simultaneous HPLC quantification of monoamines and metabolites in the blood-free rat cochlea
    Maria Angeles Vicente-Torres
    Center for Cell Culture CAI and Department of Surgery II ORL, Medicine Faculty, University Complutense of Madrid, 28040 Madrid, Spain
    J Neurosci Methods 119:31-6. 2002
    ..The present methodology may constitute a useful strategy to analyze monoamine turnover in the cochlea and other peripheral sensory receptors...
  67. ncbi Analysis of monoamines, adenosine and GABA in tissues of the land snail Helix lucorum and lizard Agama stellio stellio during hibernation
    Basile Michaelidis
    Laboratory of Animal Physiology, Department of Zoology, Faculty of Biology, School of Science, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece
    J Exp Biol 205:1135-43. 2002
    ....
  68. ncbi Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action
    E A Fon
    Department of Neurology, UCSF School of Medicine, University of California, San Francisco 94143, USA
    Neuron 19:1271-83. 1997
    ....
  69. ncbi Sensitization to the neuroendocrine, central monoamine and behavioural effects of murine tumor necrosis factor-alpha: peripheral and central mechanisms
    S Hayley
    Institute of Neuroscience, Life Science Research Building, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Eur J Neurosci 15:1061-76. 2002
    ..Moreover, it appears that mTNF-alpha promotes central neurochemical plasticity through independent central and peripheral mechanisms...
  70. ncbi [Effect of cross-fostering on catalepsy and the brain monoamine level in rat offspring prone to catalepsy and in the control strain]
    V G Kolpakov
    Institute of Cytology and Genetics, Russian Acad. Sci, Siberian Branch, Russia, 630090, Novosibirsk, Pr. Lavrentyeva, 10
    Ross Fiziol Zh Im I M Sechenova 87:918-25. 2001
    ..The cross-fostering diminished interstrain differences in the NA level in cortex, striatum, and hypothalamus...
  71. ncbi Dramatic brain aminergic deficit in a genetic mouse model of phenylketonuria
    S Puglisi-Allegra
    Dipartimento di Psicologia, Universita La Sapienza, Rome, Italy
    Neuroreport 11:1361-4. 2000
    ..NE content and metabolism were reduced in pFC, Cg, AMY and HIP. Finally, significantly reduced DA content and metabolism was observed in pFC, NAc, CP and AMY. In pFC, NAc and CP there was also a marked reduction of DA release...
  72. ncbi Nitroglycerin-induced activation of monoaminergic transmission in the rat
    C Tassorelli
    IRCCS Neurological Institute, C Mondino Foundation, Pavia, Italy
    Cephalalgia 22:226-32. 2002
    ..These data might therefore help to clarify the mechanisms underlying the delayed migraine attack observed in migraine sufferers after systemic administration of nitroglycerin...
  73. ncbi Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain
    Richard B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, 5500 Nathan Shock Drive, 21224, Baltimore, MD, USA
    Eur J Pharmacol 447:51-7. 2002
    ..The collective findings suggest that phendimetrazine is a "prodrug" that is converted to the active metabolite phenmetrazine, a potent substrate for norepinephrine and dopamine transporters...
  74. ncbi Effects of acute and chronic reboxetine treatment on stress-induced monoamine efflux in the rat frontal cortex
    Michelle E Page
    Department of Psychiatry, University of Pennsylvania, 538 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 27:237-47. 2002
    ..Taken together, these data support the view that the noradrenergic and dopaminergic systems are modified by reboxetine treatment and may be important factors in the mechanism of action of antidepressant compounds...
  75. ncbi Neurochemical measurements in the brains of mice infected with Trypanosoma brucei brucei (TREU 667)
    B Amole
    Faculty of Health Sciences, University Obafemi Awolowo, Ile Ife, Nigeria
    Ann Trop Med Parasitol 83:225-32. 1989
    ..These data may form the basis for the neuropsychiatric abnormalities that are associated with this disease...
  76. ncbi Effects of hokoei-to (pugongying-tang), a Kampo formula, on monoamine content in brain regions and mitogenic activity of splenic lymphocytes in ovariectomized mice
    Q H Song
    The Research Division, Oriental Medicine Research Center, The Kitasato Institute, Tokyo, Japan
    Am J Chin Med 29:433-43. 2001
    ..The mitogenic activity of lymphocytes in the spleen was reduced after ovariectomy; a suppression of this reduced activity was observed in the group given hokoei-to...
  77. ncbi Effects of acetaminophen on monoaminergic systems in the rat central nervous system
    J P Courade
    UPSA Laboratoires (Bristol-Myers Squibb group, Paris La Defense, France
    Naunyn Schmiedebergs Arch Pharmacol 364:534-7. 2001
    ..These results indicate that acetaminophen affects central monoaminergic neurotransmission, thereby suggesting that monoamines (especially 5-HT) might participate in its analgesic action...
  78. ncbi Changes in endogenous monoamines in aged rats
    J J Lee
    Department of General Surgery, Mackay Memorial Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
    Clin Exp Pharmacol Physiol 28:285-9. 2001
    ..4. These data suggest that ageing may alter endogenous monoamines in both the brain and peripheral tissues...
  79. ncbi The effect of sumatriptan on brain monoamines in rats
    D D Mitsikostas
    Laboratory of Experimental Pharmacology, Athens University, School of Medicine, Greece
    Headache 36:29-31. 1996
    ..No dose-dependent effect of the drug was found. This subcortical antidopaminergic and antiserotoninergic effect of sumatriptan may be involved in its antimigraine action...
  80. ncbi Effects of neonatal handling on basal and stress-induced monoamine levels in the male and female rat brain
    A Papaioannou
    Laboratory of Biology Biochemistry, School of Health Sciences, University of Athens, Papadiamantopoulou 123, Athens, GR 11527, Greece
    Neuroscience 114:195-206. 2002
    ..Exposure to either short- or long-term stress in adult life results in sex-dependent changes in brain monoamines, which are affected by handling thus making coping more efficient and rendering the stressful stimulus less noxious...
  81. ncbi Postsynaptic 5-HT(1A) receptors mediate an increase in locomotor activity in the monoamine-depleted rat
    Laurence Mignon
    Department of Pharmacology and Experimental Therapeutics, Loyola University, Stritch School of Medicine, Maywood, IL 60153, USA
    Psychopharmacology (Berl) 163:85-94. 2002
    ..However, the exact mechanism remains unclear...
  82. ncbi Sleep deprivation in the rat: XVIII. Regional brain levels of monoamines and their metabolites
    B M Bergmann
    Department of Psychiatry, University of Chicago, Illionis
    Sleep 17:583-9. 1994
    ..The most common outlying values were for TSC rats. Thus, these results failed to demonstrate sleep loss-induced regional changes in levels of major brain monoamines or their metabolites.(ABSTRACT TRUNCATED AT 250 WORDS)..
  83. ncbi Carotid labyrinth of amphibians
    Tatsumi Kusakabe
    Laboratory for Anatomy and Physiology, Department of Sport and Medical Science, Kokushikan University, Tokyo 206 8515, Japan
    Microsc Res Tech 59:207-26. 2002
    ..In fluorescence histochemistry, the glomus cells emit intense fluorescence for biogenic monoamines. In fine structure, the glomus cells are characterized by a number of dense-cored vesicles in their ..
  84. ncbi Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats)
    V D Petkov
    Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia
    Gen Pharmacol 21:71-5. 1990
    ..5. An attempt is made to explain some similarities and differences in the behavioral effects of the drugs tested (and those observed in other studies) by the changes they induce in brain biogenic monoamines.
  85. ncbi Memory effects of the new derivative of the p-chlorophenoxyacetic acid adafenoxate compared to the effects of some cognition-enhancing drugs in rats
    V D Petkov
    Institute of Physiology, Bulgarian Academy of Sciences, Sofia
    Arzneimittelforschung 39:1133-6. 1989
    ..other data previously obtained about the effects of the drugs tested and of other nootropic drugs on brain biogenic monoamines, it is suggested that induced changes in biogenic monoamines are responsible for the similarities and the ..
  86. ncbi Up-regulation of circulating hemocyte population in response to bacterial challenge is mediated by octopamine and 5-hydroxytryptamine via Rac1 signal in Spodoptera exigua
    Geun Seob Kim
    Department of Bioresource Sciences, Andong National University, Andong 760 749, Republic of Korea
    J Insect Physiol 56:559-66. 2010
    ..This study analyzed the effects of both biogenic monoamines on mediating up-regulation of circulating hemocyte population in response to bacterial challenge...
  87. ncbi [Mechanism of action of antidepressants and therapeutic perspectives]
    M Bourin
    Laboratoire de Neuropharmacologie UPRES EAD MENRT, Institut de signalisation et d innovation thérapeutique IFR75, Faculte de Pharmacie, Universite Paris Sud, Chatenay Malabry, France
    Therapie 57:385-96. 2002
    ..Depression is due to a deficiency in one or other biogenic monoamines (serotonin, 5-HT; noradrenaline, NA; dopamine, DA)...
  88. ncbi Reduced folate transport to the CNS in female Rett patients
    V T Ramaekers
    Division of Pediatric Neurology, Department of Pediatrics, University Hospital Aachen, Germany
    Neurology 61:506-15. 2003
    Previous CSF studies in Rett syndrome suggest reduced turnover of the biogenic monoamines serotonin and dopamine...
  89. ncbi Octopamine and 5-hydroxytryptamine mediate hemocytic phagocytosis and nodule formation via eicosanoids in the beet armyworm, Spodoptera exigua
    Geun Seob Kim
    Department of Bioresource Sciences, Andong National University, Andong 760 749, Korea
    Arch Insect Biochem Physiol 70:162-76. 2009
    ..exigua. These effects of biogenic monoamines on the immune mediation were expressed through eicosanoids because the inhibitory effects of both ..
  90. ncbi HPLC analysis of serotonin, tryptamine, tyramine, and the hydroxycinnamic acid amides of serotonin and tyramine in food vegetables
    Dalin Ly
    Department of Biotechnology BK21 Program, Environmental Friendly Agricultural Research Center, Biotechnology Research Institute, Chonnam National University, Gwangju, Republic of Korea
    J Med Food 11:385-9. 2008
    b>Biogenic monoamines such as serotonin, tryptamine, and tyramine function as neurotransmitters and mitogenic factors in animals and are involved in flowering, morphogenesis, and protection from and adaptation to environmental changes in ..
  91. ncbi Effects of the nootropic agents adafenoxate and meclofenoxate on brain biogenic monoamines in aged rats
    S L Stancheva
    Institute of Physiology, Bulgarian Academy of Sciences
    Acta Physiol Pharmacol Bulg 14:14-21. 1988
    The effect of the nootropic agents meclofenoxate (Mf) and adafenoxate (Adf) on the content of biogenic monoamines in the frontal cerebral cortex, striatum, hypothalamus, and hippocampus of 22-month-old rats was studied...
  92. ncbi Monoamine oxidase in amphistomes and its role in worm motility
    S M Abidi
    Section of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh, 202 002
    J Helminthol 74:283-8. 2000
    ..amphistomes, further indicating the involvement of different forms of MAO in the oxidative deamination of biogenic monoamines which might be partly responsible for neuromuscular coordination in amphistomes...
  93. ncbi Psychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: a novel neurometabolic condition responding to folinic acid substitution
    V T Ramaekers
    Division of Paediatric Neurology, Department of Paediatrics, University Hospital Aachen, Aachen, Germany
    Neuropediatrics 33:301-8. 2002
    ..The folate receptor-1 (FR 1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5-MTHF)...
  94. ncbi Biogenic amines, metabolites and monoamine oxidase in the filarial worm Setaria cervi
    A Agarwal
    Division of Biochemistry, Central Drug Research Institute, Lucknow, India
    Int J Parasitol 20:873-81. 1990
    Analysis of biogenic monoamines and their metabolites in Setaria cervi adults by reverse phase high performance liquid chromatography (HPLC) revealed dopamine as the major monoamine followed by norepinephrine and 5-hydroxytryptamine (5-..
  95. ncbi The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the level of brain biogenic monoamines in rats with angiotensin II-induced increase of water intake
    S Stancheva
    Radioisotope Laboratory, Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Methods Find Exp Clin Pharmacol 24:287-90. 2002
    ..II (Ang II)-receptor antagonists (losartan, EXP-3174, saralasin and sarmesin) on the levels of the biogenic monoamines dopamine, noradrenaline and serotonin in the frontal cortex, striatum, hypothalamus and hippocampus of rats ..
  96. ncbi Involvement of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine in Wistar rats: implication of postsynaptic 5-HT1A receptors
    Petros N Karamanakos
    Department of Pharmacology, Medical School, University of Ioannina, University Campus, 45110 Ioannina, Greece
    Behav Brain Res 148:199-208. 2004
    ..investigate the influence of CPA on the locomotor activity of the rat in relation to its effects on brain biogenic monoamines. Wistar rats were given CPA (40 mg/kg, i.p.) and locomotor activity was measured in a photocell cage...
  97. ncbi Early postnatal effects of prenatal exposure to glucocorticoids on testosterone metabolism and biogenic monoamines in discrete neuroendocrine regions of the rat brain
    A G Reznikov
    Department of Endocrinology of Reproduction and Adaptation, VP Komissarenko Institute of Endocrinology and Metabolism, 69, Vyshgorodskaya St, Kiev 04114, Ukraine
    Comp Biochem Physiol C Toxicol Pharmacol 138:169-75. 2004
    ....
  98. ncbi Effects of chronic diazepam and medazepam treatment on the level of biogenic monoamines in different rat brain areas
    S Stancheva
    Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia
    Acta Physiol Pharmacol Bulg 14:26-31. 1988
    ..kg-1, i.p.) and medazepam (5 mg.kg-1, i.p.) on the level of biogenic monoamines in different rat brain areas: cerebral cortex, striatum, hippocampus, and hypothalamus...
  99. ncbi Comparative studies on the central effects of the angiotensin II analogue (Sar1 azaVal3 Ile8) AT II
    V P Georgiev
    Institute of Physiology, Bulgarian Academy of Sciences, Sofia
    Acta Physiol Pharmacol Bulg 14:22-9. 1988
    ..AT II, using intracerebroventricular administration, with respect to the following parameters: the level of biogenic monoamines (DA, NA and 5-HT) and the metabolites HVA and 5-HIAA in mouse forebrain; the behaviour of the animals--..
  100. ncbi Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1
    M Essand
    Division of Clinical Immunology, Uppsala University, Sweden
    J Mol Endocrinol 35:489-501. 2005
    ..in the membrane of secretory vesicles of neuroendocrine and endocrine cells that allows the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles...
  101. ncbi A transporter for phenolamine uptake in the arthropod CNS
    B Cameron Donly
    Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, London, Ontario, Canada
    Arch Insect Biochem Physiol 59:172-83. 2005
    b>Biogenic monoamines play central roles in the nervous control of physiological processes in both vertebrates and invertebrates, each using a suite of neurotransmitters tailored through evolution...

Research Grants64

  1. GENETIC AND BIOCHEMICAL DISSECTION OF PROLACTIN ACTIONS
    NELSON HORSEMAN; Fiscal Year: 2006
    ..These discoveries imply that biogenic monoamines (esp. 5-HT) are important mammary-derived signaling molecules...
  2. SLEEP DEPRIVATION AND 5-HT AUTOREGULATORY PROCESSES
    RUSSELL POLAND; Fiscal Year: 2005
    ..to supplement his background in electrophysiology with techniques in neurochemistry (microdialysis of biogenic monoamines in behaving animals and high performance liquid chromatography) and molecular biology, which he plans to ..
  3. ELECTROCHEMISTRY-EPR OF BIOLOGICAL ELECTRON TRANSFER
    Ralph Adams; Fiscal Year: 1992
    This research is of a twofold nature--to study both the static and dynamic properties of the biogenic monoamines. Detailed three-dimensional maps of the concentrations of norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT) and ..
  4. COCAINE: A STUDY OF THE BIOCHEMICAL MECHANISM OF ACTION
    Frank Carroll; Fiscal Year: 2007
    ..abstract_text> ..
  5. MONOAMINERGIC CONTROL OF SPINAL INTERNEURONS
    CHARLES HECKMAN; Fiscal Year: 2004
    ..These studies are likely to lead to novel pharmacological strategies to help restore normal function in spinal cord injury and stroke. ..
  6. Increased persistent sodium current in SOD1 motoneurons
    CHARLES HECKMAN; Fiscal Year: 2009
    ..These studies will play an essential role in determining if NaP makes an important contribution to motoneuron degeneration in ALS. Moreover, the results may prove invaluable in establishing new therapeutic strategies ..
  7. NOVEL PHARMACOTHERAPIES FOR COCAINE DEPENDENCE
    Frank Carroll; Fiscal Year: 2001
    ..An ideal candidate compound would not only have efficacy in the preclinical models but would be safe, orally active, and potent, would not show tolerance or sensitization, and if abusable, would be less so than cocaine. ..
  8. Design and Development of Pharmacotherapies for Treating Stimulant Abuse
    Frank Ivy Carroll; Fiscal Year: 2010
    ..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
  9. NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTION
    Frank Carroll; Fiscal Year: 2008
    ..abstract_text> ..
  10. Conference on the Diagnosis of Multiple System Atrophy
    Sid Gilman; Fiscal Year: 2006
    ..This conference will assist with early diagnosis by developing new guidelines for diagnosis using newly available imaging and neuropathological criteria. [unreadable] [unreadable] [unreadable]..
  11. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  12. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  13. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  14. IRON DEFICIENCY AND DOPAMINE
    John Beard; Fiscal Year: 2004
    ..This expansion of study to other neurotransmitters will significantly contribute to our knowledge of the effects of iron deficiency on brain functioning in early life. ..
  15. Evaluating Striatal Function in a Murine HD Model
    Roger Albin; Fiscal Year: 2007
    ..Validation of these methods will provide new and useful behavioral tools for evaluating murine disease models. [unreadable] [unreadable] [unreadable]..
  16. DIENCEPHALIC MECHANISMS OF DRUG ABUSE
    STANLEY GLICK; Fiscal Year: 2008
    ..The work proposed here may ultimately result in new kinds of treatments for drug abuse. ..
  17. Age at First Sex, Genes, Religion, and Other Social and Demographic Context
    Guang Guo; Fiscal Year: 2007
    ....
  18. Arousal and Attention in Cocaine-Exposed Children
    Linda Mayes; Fiscal Year: 2007
    ..Such interactions place cocaine-exposed children at higher risk for externalizing forms of psychopathology. ..
  19. Transdermal Nicotine Treatment of MCI
    Paul Newhouse; Fiscal Year: 2007
    ..If nicotine proves successful in alleviating cognitive symptoms and in improving global outcomes along with reasonable safety, we will propose a large multicenter clinical trial. ..
  20. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  21. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
    ..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
  22. Homer proteins, glutamate and alcoholism
    KAREN SZUMLINSKI; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. mGluR-Homer interactions in excessive drinking
    KAREN SZUMLINSKI; Fiscal Year: 2008
    ..abstract_text> ..
  24. PSYCHOBIOLOGY OF CORTICOTROPIN-RELEASING FACTOR
    Michael Owens; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. REGULATION OF SEROTONIN TRANSPORTERS
    Randy D Blakely; Fiscal Year: 2010
    ....
  26. Transgenic Mouse Model to Address Heterogeneity in Autism Spectrum Disorders
    RANDY DEAN BLAKELY; Fiscal Year: 2010
    ..Based on exciting preliminary evidence that mice expressing Ala56 SERT exhibit multiple behavioral and biochemical phenotypes, we propose a two-year project to extend our studies and dissect the impact of SERT hyperfunction in vivo. ..
  27. Functional effects of mGluR potentiators in the CNS
    P Jeffrey Conn; Fiscal Year: 2010
    ....
  28. Effect of Biomechanical Force Exposure on Cognition & Brain Activation in Student
    Thomas McAllister; Fiscal Year: 2009
    ..Impact parameters will be directly measured using helmet-based accelerometer units. ..
  29. Estrogen Effects on Cholinergic Function in Older Women
    Paul Newhouse; Fiscal Year: 2008
    ..abstract_text> ..
  30. NICOTINE ADDICTION IN MICE LACKING THE NEURONAL NACHR
    MARINA PICCIOTTO; Fiscal Year: 2009
    ..We propose that this mouse model may have implications for the development of psychiatric disorders in subjects exposed to nicotine in utero. ..
  31. Cocaine-Exposed Children & ERP Studies of Neurocognition
    Linda Mayes; Fiscal Year: 2008
    ..Such information may then lead to better definition and treatment of these developmental problems. ..
  32. Antidepressants - same effect on mesolimbic DA activity?
    JAY WEISS; Fiscal Year: 2009
    ....
  33. PB-Environmental Stress Interactions: Re-evaluating Risk
    Deborah Cory Slechta; Fiscal Year: 2009
    ..If Pb alters corticosterone and stress responsiveness, it could also modulate susceptibility to disease and dysfunction. ..
  34. SOY, LIFE STAGE, STRESS AND ATHEROSCLEROSIS IN FEMALES
    JAY KAPLAN; Fiscal Year: 2009
    ....
  35. Modular Abnormalities of Brain Organization in Autism
    Manuel Casanova; Fiscal Year: 2007
    ..Treatment modalities, especially neuropharmaceutical agents, will prove more specific as their targets are better understood. ..
  36. STEROID HORMONES--BRAIN AND BEHAVIOR
    ANNE ETGEN; Fiscal Year: 2007
    ..These studies will provide novel[unreadable] insights into the cellular and molecular mechanisms by which ovarian[unreadable] sterioids act in the brain and to produce predictable behavioral[unreadable] changes. ..
  37. mGluR4 Potentiators as a Treatment for Parkinson's Disease
    P Conn; Fiscal Year: 2007
    ..This high throughput screen will provide the basis for future studies aimed at developing allosteric potentiators of mGluR4 that are suitable for clinical testing. [unreadable] [unreadable]..
  38. Throughput Assay:Allosteric Potentiator of GluR (RMI)
    P Conn; Fiscal Year: 2004
    ..This will provide the characterization needed to allow us to optimize this assay for use in future screens of larger compound libraries. ..
  39. BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSION
    David Wirtshafter; Fiscal Year: 2003
    ..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
  40. Reduced Interneuronal Space in Schizophrenic Brains
    Manuel Casanova; Fiscal Year: 2005
    ..If our preliminary findings are corroborated, the smaller than normal minicolumns will demonstrate a reorganization of brain circuitry most probably defined during development. ..
  41. AROUSAL REGULATORY FUNCTIONS IN COCAINE-EXPOSED CHILDREN
    Linda Mayes; Fiscal Year: 2004
    ..Early disruption of the developmental ontogeny of arousal and attentional regulatory capacities may have effects that extend well into the school-aged years and alter the normal trajectory of cognitive and social-emotional development. ..
  42. New Perspectives in Transporter Biology-FASEB conference
    Robert Edwards; Fiscal Year: 2003
    ..Each oral session will be followed by a panel discussion of the topic. To promote the advancement of junior faculty, the most exciting poster submissions will be selected for short oral presentations during the regular oral sessions. ..
  43. A Neurogenomic Model for Dopamine Transporter Regulation
    Randy Blakely; Fiscal Year: 2002
    ..elegans DAT (CeDAT) expression in cultured DA neurons and 2) to develop a system where a combination of transgenic and proteomic approaches can be applied to permit the evaluation of hypothesized and novel DAT regulators. ..
  44. CORTICOLIMBIC SYSTEM AND SCHIZOPHRENIA
    Francine Benes; Fiscal Year: 2002
    ....
  45. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  46. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  47. Controllability of Stress--Effects on Tumor Development
    JAY WEISS; Fiscal Year: 2004
    ..Finally, these approaches will be combined by assessing how control vs. non-control affects lymphocyte-tumor cell interaction assessed by histological analysis. ..
  48. NEUROBEHAVIORAL MECHANISMS OF DRUG ADDICTION
    STANLEY GLICK; Fiscal Year: 2001
    ..This research may result in novel treatments for addictive disorders in humans. ..
  49. RUPP-PI
    Christopher McDougle; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] ..
  50. GENETIC ANALYSIS OF DOPAMINERGIC REWARD MECHANISMS
    Marc Caron; Fiscal Year: 2005
    ..This should allow identification of genes involved in stable alterations of the CNS associated with chronic drug exposure. ..
  51. DOPAMINE TRANSPORTER AGENTS AGAINST COCAINE DEPENDENCE
    ALOKE DUTTA; Fiscal Year: 2007
    ..Compounds selected based on their in vitro activity will be tested for effects on locomotor activity and drug discrimination and self-administration studies to assess their potential in replacement therapy. ..
  52. Social Information Processing: Assessment Development
    EMIL COCCARO; Fiscal Year: 2007
    ..Development of such measures is critical for the further scientific study of SIP and for its integration in neurobiologhical research. [unreadable] [unreadable]..
  53. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  54. NEUROENDOCRINE BASES OF REPRODUCTIVE BEHAVIOR
    ANNE ETGEN; Fiscal Year: 2006
    ..Specific Aim 4 will determine how IGF-1 acutely potentiates a1-adrenoceptor signaling in the HYP-POA of E2-treated females and whether this is important for reproductive behavior. ..
  55. TRANSPORT OF NEUROTRANSMITTERS INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2005
    ..Third, we will manipulate the expression, localization and regulation of the transporters in vivo to assess the role of these mechanisms in synaptic transmission and behavior. ..
  56. Dopamine Receptors: Characterization and Regulation
    Marc Caron; Fiscal Year: 2007
    ..abstract_text> ..
  57. Environmental Risk Factors and Canine Malignant Lymphoma
    Elizabeth Bertone Johnson; Fiscal Year: 2005
    ..Because dogs and their human owners share a common environment within the household, results from this study will have direct relevance to the on-going effort to identify factors that may increase risk of human NHL. ..
  58. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
    ..Phase II (following 6 months of aripiprazole monotherapy). ..
  59. Evoked potentials and vulnerability to ketamine in mice.
    Steven Siegel; Fiscal Year: 2004
    ..abstract_text> ..
  60. Effects of self-administered MDMA on brain and behavior in rhesus monkeys
    William Fantegrossi; Fiscal Year: 2007
    ..Thus, these studies are likely to be more relevant to the potential human condition of MDMA-induced lasting neurochemical alterations and behavioral changes [unreadable] [unreadable]..
  61. Paradoxical Antidepressant Action in Locus Coeruleus during Development
    JAY WEISS; Fiscal Year: 2009
    ....
  62. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  63. Methamphetamine, procedural learning, and plasticity
    DAVID DABERKOW; Fiscal Year: 2005
    ..abstract_text> ..