diphenylamine

Summary

Summary: In humans it may be irritating to mucous membranes. Methemoglobinemia has been produced experimentally. In veterinary use, it is one of active ingredients in topical agents for prevention and treatment of screwworm infestation. An indicator in tests for nitrate poisoning.

Top Publications

  1. ncbi In situ UV-visible spectroelectrochemical studies on the copolymerization of diphenylamine with ortho-methoxy aniline
    P Santhosh
    Department of Industrial Chemistry, Alagappa University, 630003, Karaikudi, India
    Spectrochim Acta A Mol Biomol Spectrosc 59:1427-39. 2003
  2. ncbi Relationship of superficial scald development and alpha-farnesene oxidation to reactions of diphenylamine and diphenylamine derivatives in Cv. Granny Smith apple peel
    David R Rudell
    Tree Fruit Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 1104 N Western Ave, Wenatchee, Washington 98801, USA
    J Agric Food Chem 53:8382-9. 2005
  3. ncbi UV-vis spectroscopy for following the kinetics of homogeneous polymerization of diphenylamine in p-toluene sulphonic acid
    S Nagarajan
    Department of Industrial Chemistry, Alagappa University, Karaikudi, 630003 Tamil Nadu, India
    Spectrochim Acta A Mol Biomol Spectrosc 62:420-30. 2005
  4. ncbi Characterization of three members of the electron-transfer series [Fe(pda)2]n (n=2-, 1-, 0) by spectroscopy and density functional theoretical calculations [pda=redox non-innocent derivatives of N,N'-bis(pentafluorophenyl)-o-phenylenediamide(2-, 1.-, 0)]
    Marat M Khusniyarov
    Max Planck Institut fur Bioanorganische Chemie, Stiftstrasse 34 36, 45470 Mulheim an der Ruhr, Germany
    Chemistry 14:7608-22. 2008
  5. pmc BRAF mutation predicts sensitivity to MEK inhibition
    David B Solit
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nature 439:358-62. 2006
  6. ncbi The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
    Stephen D Barrett
    Department of Chemistry, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Bioorg Med Chem Lett 18:6501-4. 2008
  7. ncbi A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer
    Eric B Haura
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Clin Cancer Res 16:2450-7. 2010
  8. ncbi Ketocarotenoid biosynthesis outside of plastids in the unicellular green alga Haematococcus pluvialis
    K Grunewald
    Institute of General Botany, Friedrich Schiller University Jena, Am Planetarium 1, D 07743 Jena, Germany
    J Biol Chem 276:6023-9. 2001
  9. ncbi RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer
    Cory Iverson
    Research and Development, Ardea Biosciences, Inc, San Diego, California 92121, USA
    Cancer Res 69:6839-47. 2009
  10. ncbi Population pharmacokinetic analysis of blood and joint synovial fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis
    Hanna E Silber
    Novartis Pharma AG, Modeling and Simulation Pharmacology, Postfach, Basel, Switzerland
    Pharm Res 27:2633-45. 2010

Research Grants

  1. CHLORIDE CHANNELS WITH PHOTOAFFINITY PROBES
    Bruce Branchini; Fiscal Year: 1990
  2. International Network and Registry for TMA
    Howard Trachtman; Fiscal Year: 2007
  3. Enhanced Drug Access to Eye Tissues
    John Tomich; Fiscal Year: 2004
  4. Antitumor Mechanisms of SRC Inhibitors in Lung Cancer
    Eric Haura; Fiscal Year: 2008
  5. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2006
  6. Osteoblast Derived Pathogenic Factors in Hyp Mice
    Norimoto Yanagawa; Fiscal Year: 2005
  7. Human monoclonal antibody therapy for HUS
    Howard Trachtman; Fiscal Year: 2004
  8. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
  9. Synthetic Peptide Modulators of Paracellular Conductance
    John Tomich; Fiscal Year: 2002
  10. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002

Detail Information

Publications224 found, 100 shown here

  1. ncbi In situ UV-visible spectroelectrochemical studies on the copolymerization of diphenylamine with ortho-methoxy aniline
    P Santhosh
    Department of Industrial Chemistry, Alagappa University, 630003, Karaikudi, India
    Spectrochim Acta A Mol Biomol Spectrosc 59:1427-39. 2003
    UV-visible spectroelectrochemical studies on copolymerization of diphenylamine (DPA) with ortho-methoxy aniline (OMA) were carried out for different feed ratios of DPA and OMA using indium tin oxide (ITO)-coated glass as working ..
  2. ncbi Relationship of superficial scald development and alpha-farnesene oxidation to reactions of diphenylamine and diphenylamine derivatives in Cv. Granny Smith apple peel
    David R Rudell
    Tree Fruit Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 1104 N Western Ave, Wenatchee, Washington 98801, USA
    J Agric Food Chem 53:8382-9. 2005
    Cv. Granny Smith apple fruit, treated at harvest with aqueous emulsions containing diphenylamine (DPA) and DPA derivatives, were evaluated for the peel disorder superficial scald (scald) after 6 months of cold storage at 1 degrees C plus ..
  3. ncbi UV-vis spectroscopy for following the kinetics of homogeneous polymerization of diphenylamine in p-toluene sulphonic acid
    S Nagarajan
    Department of Industrial Chemistry, Alagappa University, Karaikudi, 630003 Tamil Nadu, India
    Spectrochim Acta A Mol Biomol Spectrosc 62:420-30. 2005
    Kinetics of chemical oxidative polymerization of diphenylamine (DPA) was followed in aqueous 1M para-toluene sulphonic acid (p-TSA) using potassium peroxomonosulphate (PMS) or peroxodisulphate (PDS), independently as an oxidant...
  4. ncbi Characterization of three members of the electron-transfer series [Fe(pda)2]n (n=2-, 1-, 0) by spectroscopy and density functional theoretical calculations [pda=redox non-innocent derivatives of N,N'-bis(pentafluorophenyl)-o-phenylenediamide(2-, 1.-, 0)]
    Marat M Khusniyarov
    Max Planck Institut fur Bioanorganische Chemie, Stiftstrasse 34 36, 45470 Mulheim an der Ruhr, Germany
    Chemistry 14:7608-22. 2008
    ..The (57)Fe Mössbauer spectra of [Fe(pda)(2)](n) species in 1 and 3 show extremely large quadrupole splitting constants due to addition of the valence and covalence contributions that have been confirmed by DFT calculations...
  5. pmc BRAF mutation predicts sensitivity to MEK inhibition
    David B Solit
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nature 439:358-62. 2006
    ..These data suggest an exquisite dependency on MEK activity in BRAF mutant tumours, and offer a rational therapeutic strategy for this genetically defined tumour subtype...
  6. ncbi The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
    Stephen D Barrett
    Department of Chemistry, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Bioorg Med Chem Lett 18:6501-4. 2008
    ..Optimization of the diphenylamine core and modification of the hydroxamate side chain for cell potency, solubility, and exposure with oral ..
  7. ncbi A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer
    Eric B Haura
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Clin Cancer Res 16:2450-7. 2010
    ....
  8. ncbi Ketocarotenoid biosynthesis outside of plastids in the unicellular green alga Haematococcus pluvialis
    K Grunewald
    Institute of General Botany, Friedrich Schiller University Jena, Am Planetarium 1, D 07743 Jena, Germany
    J Biol Chem 276:6023-9. 2001
    ..and Hagen, C. (2000) Plant Physiol. 122, 1261-1268), a transport of intermediates from the site of early biosynthetic steps in the chloroplast to the site of oxygenation and accumulation in cytoplasmic lipid vesicles is proposed...
  9. ncbi RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer
    Cory Iverson
    Research and Development, Ardea Biosciences, Inc, San Diego, California 92121, USA
    Cancer Res 69:6839-47. 2009
    ..RDEA119/BAY 869766, an exquisitely selective, orally available MEK inhibitor, has been selected for clinical development because of its potency and favorable pharmacokinetic profile...
  10. ncbi Population pharmacokinetic analysis of blood and joint synovial fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis
    Hanna E Silber
    Novartis Pharma AG, Modeling and Simulation Pharmacology, Postfach, Basel, Switzerland
    Pharm Res 27:2633-45. 2010
    ..The purpose of this population analysis was to characterize the pharmacokinetic properties of robenacoxib in blood and stifle joint synovial fluid of dogs...
  11. pmc Pathway and evolutionary implications of diphenylamine biodegradation by Burkholderia sp. strain JS667
    Kwanghee A Shin
    School of Civil and Environmental Engineering, Georgia Institute of Technology, 311 Ferst Dr, Atlanta, GA 30332 0512, USA
    Appl Environ Microbiol 75:2694-704. 2009
    b>Diphenylamine (DPA) is a common contaminant at munitions-contaminated sites as well as at aniline manufacturing sites...
  12. pmc The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
    Eric W Joseph
    Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:14903-8. 2010
    ..This selectivity may lead to a broader therapeutic index and help explain the greater antitumor activity observed with this drug than with MEK inhibitors...
  13. ncbi Asymmetric Friedel-Crafts alkylation of indoles with 3-nitro-2H-chromenes catalyzed by diphenylamine-linked bis(oxazoline) and bis(thiazoline) Zn(II) complexes
    Yang Jia
    School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, People s Republic of China
    Org Biomol Chem 10:4739-46. 2012
    ..diastereo- and enantioselective Friedel-Crafts alkylation of indoles with 3-nitro-2H-chromenes catalyzed by diphenylamine-linked bis(oxazoline) and bis(thiazoline) Zn(II) complexes has been developed...
  14. pmc Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-kappaB pathways
    Dingxie Liu
    Division of Endocrinology and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, 1830 E Monument Street, Baltimore, MD 21287, USA
    Thyroid 18:853-64. 2008
    ..The objective of this study was to use a potent new-generation MEK inhibitor PD0325901 to further investigate the therapeutic potential of specifically targeting MEK in the MAP kinase pathway for thyroid cancer...
  15. ncbi Targeting mitogen-activated protein kinase kinase with the inhibitor PD0325901 decreases hepatocellular carcinoma growth in vitro and in mouse model systems
    Matthew Hennig
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Hepatology 51:1218-25. 2010
    ..These studies provide compelling preclinical evidence that targeting MEK in human clinical trials may be promising for the treatment of HCC...
  16. ncbi Orally active anti-proliferation agents: novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors
    Toshiyuki Shimizu
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, 3 Miyahara, Takasaki, Gunma, 370 1295, Japan
    Bioorg Med Chem Lett 14:875-9. 2004
    ..In this study, we achieved a remarkable improvement in the solubility and metabolic stability of the diphenylamine derivative...
  17. ncbi Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway
    Judith S Sebolt-Leopold
    Oncovera Therapeutics, Ann Arbor, Michigan 48103, USA
    Clin Cancer Res 14:3651-6. 2008
    ....
  18. ncbi Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression
    Marie Emmanuelle Legrier
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:11300-8. 2007
    ..These data (a) provide evidence that both pathways converge on factors that regulate translation initiation and (b) support therapeutic strategies in lung cancer that simultaneously suppress the RAS and AKT signaling network...
  19. ncbi Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers
    Patricia M LoRusso
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Clin Cancer Res 16:1924-37. 2010
    ..To determine tolerability, pharmacokinetics, and pharmacodynamics of PD-0325901, a highly potent, selective, oral mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase 1/2 inhibitor in advanced cancer patients...
  20. pmc A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives
    Asher Peretz
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 2:e1332. 2007
    ..2/3 K(+) channels underlying the neuronal M-current. Here we designed new derivatives of diphenylamine carboxylate to dissociate the M-channel opener property from COX inhibition...
  21. ncbi Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration
    Alan P Brown
    Drug Safety Research and Development, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Cancer Chemother Pharmacol 59:671-9. 2007
    ..Measurement of pMAPK in normal tissues served as a means for assessing the pharmacologic activity of PD0325901 and should be included in toxicity studies to evaluate toxicity-pharmacology relationships...
  22. ncbi The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury
    Yan Li
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Toxicol Lett 186:111-4. 2009
    Many nonsteroidal anti-inflammatory drugs (NSAIDs) with diphenylamine structure induce severe hepatotoxicities. We evaluated the role of diphenylamine structure in liver injuries induced by these NSAIDs.
  23. ncbi Syntheses and anti-inflammatory activity of diphenylamine-2,2'-dicarboxylic acid and its metal complexes
    Govind Mohan
    Department of Pharmacology, S N Medical College, Agra 282 002, India
    J Enzyme Inhib Med Chem 20:55-60. 2005
    b>Diphenylamine-2,2'-dicarboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic ..
  24. ncbi Facile synthesis and intrinsic conductivity of novel pyrrole copolymer nanoparticles with inherent self-stability
    Xin Gui Li
    Institute of Materials Chemistry, Key Laboratory of Advanced Civil Engineering Materials, College of Materials Science and Engineering, Tongji University, Shanghai, China
    J Phys Chem B 111:5829-36. 2007
    Intrinsically self-stabilized nanoparticles of a copolymer from 4-sulfonic diphenylamine (SD) and pyrrole (PY) were facilely synthesized in HCl solution at 10 degrees C by a chemically oxidative polymerization...
  25. ncbi Evaluation of diphenylamine derivatives in apple peel using gradient reversed-phase liquid chromatography with ultraviolet-visible absorption and atmospheric pressure chemical ionization mass selective detection
    David R Rudell
    Tree Fruit Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 1104 N Western Ave, Wenatchee, WA 98801, USA
    J Chromatogr A 1081:202-9. 2005
    A method was developed for extracting, identifying, and quantifying diphenylamine (DPA) derivatives in the peel of DPA-treated apples using gradient reversed-phase liquid chromatography with ultraviolet-visible absorption and atmospheric ..
  26. ncbi Current rectification in a Langmuir-Schaefer monolayer of fullerene-bis-[4-diphenylamino-4' '-(n-ethyl-n-2' ''-ethyl)amino-1,4-diphenyl-1,3-butadiene] malonate between Au electrodes
    Andrei Honciuc
    Laboratory for Molecular Electronics, Chemistry Department, University of Alabama, Tuscaloosa, Alabama 35487 0336, USA
    J Phys Chem B 109:857-71. 2005
    ..0 to +/-5.4 V, with rectification ratios up to 16.5. The rectification is ascribed to the asymmetric placement of the relevant molecular orbitals, with respect to the metallic electrodes...
  27. ncbi In situ UV-visible spectroelectrochemical evidences for conducting copolymer formation between diphenylamine and m-methoxyaniline
    M Thanneermalai
    Department of Industrial Chemistry, Alagappa University, Karaikudi 630003, India
    Spectrochim Acta A Mol Biomol Spectrosc 59:1937-50. 2003
    Electrochemical copolymerization of diphenylamine (DPA) with m-methoxy aniline (MA) was carried out in 4 M H(2)SO(4) by cyclic voltammetry (CV)...
  28. ncbi In situ UV-Vis spectroelectrochemical studies to identify electrochromic sites in poly(1-naphthylamine) modified by diphenylamine
    Chein Yie Chung
    Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan
    Spectrochim Acta A Mol Biomol Spectrosc 60:585-93. 2004
    Poly(1-napthylamine) (PNPA) was modified by incorporation of diphenylamine (DPA) to result copolymer film on the indium tin oxide (ITO) coated glass electrode using cyclic voltammetry...
  29. ncbi Thiophene-thiophene versus phenyl-phenyl coupling in 2-(Diphenylamino)-Thiophenes: an ESR-UV/Vis/NIR spectroelectrochemical study
    Peter Rapta
    IFW Dresden, Institute of Solid State Research, Department of Electrochemistry and Conducting Polymers, Helmholtzstrasse 20, 01069 Dresden, Germany
    Chemphyschem 7:863-70. 2006
    ..By in situ spectroelectrochemistry the influence of the substituents on the type of coupling reactions can be demonstrated and followed in detail...
  30. ncbi Effect of dual fullerenes on lifetimes of charge-separated States of subphthalocyanine-triphenylamine-fullerene molecular systems
    Mohamed E el-Khouly
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Sendai, 980 8577 Japan
    J Phys Chem B 112:3910-7. 2008
    ..Interestingly, further charge stabilization was achieved in the charge-separated state of SubPc-TPA-(C(60))(2), in which the tau(RIP) was found to be 1050 ns in benzonitrile...
  31. ncbi A comparative study between PCR and PLS in simultaneous spectrophotometric determination of diphenylamine, aniline, and phenol: Effect of wavelength selection
    Bahram Hemmateenejad
    Chemistry Department, Shiraz University, Shiraz 71454, Iran
    Spectrochim Acta A Mol Biomol Spectrosc 67:958-65. 2007
    ..was made between PCR and PLS methods by application those to simultaneous spectrophotometric determination of diphenylamine (DPA), a compound from the third European Union list of priority pollutants, and its environmentally related ..
  32. ncbi Micell-mediated extraction for the spectrophotometric determination of nitrite in water and biological samples based on its reaction with p-nitroaniline in the presence of diphenylamine
    Abbas Afkhami
    Department of Chemistry, Faculty of Sciences, Bu Ali Sina University, Hamadan 65174, Iran
    Anal Biochem 336:295-9. 2005
    ..The method is based on the color reaction of nitrite with p-nitroaniline in the presence of diphenylamine in acid media and micell-mediated extraction of an azo product...
  33. ncbi Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs
    Maria Victoria Gómez-Gaviro
    Servicio de Reumatologia, Hospital de la Princesa, Universidad Autonoma de Madrid, C Diego de Leon 62, Madrid 28006, Spain
    J Biol Chem 277:38212-21. 2002
    ..Only NSAIDs from the high releaser group shared diphenylamine in their chemical structure...
  34. ncbi Orally bioavailable competitive CCR5 antagonists
    Gebhard Thoma
    Novartis Institutes for BioMedical Research, Lichtstrasse 35, WSJ 507 4 12, CH 4056 Basel, Switzerland
    J Med Chem 47:1939-55. 2004
    ..One of these compounds, i.e., 26n, has good PK properties in cynos, and its overall favorable profile makes it a promising candidate for in vivo profiling in transplantation and other disease models...
  35. ncbi Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton
    Takuma Komatsu
    School of Biomedical Science, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Bioorg Med Chem 15:3115-26. 2007
    ..We designed and synthesized novel diphenylamine derivatives with a thiazolidinedione moiety as the terminal polar group as thyroid hormone receptor (TR) ..
  36. ncbi Asymmetric Friedel-Crafts alkylation of methoxyfuran with nitroalkenes catalyzed by diphenylamine-tethered bis(oxazoline)-Zn(II) complexes
    Han Liu
    Beijing National Laboratory for Molecular Sciences BNLMS, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, P R China
    Org Lett 9:4725-8. 2007
    ..asymmetric Friedel-Crafts reaction of 2-methoxyfuran with nitroalkenes was developed under the catalysis of diphenylamine-tethered bis(oxazoline)-Zn(OTf)2 complexes...
  37. ncbi Production of volatile compounds by Fuji apples following exposure to high CO2 or low O2
    Luiz C Argenta
    ARS Tree Fruit Research Laboratory, U S Department of Agriculture, 1104 North Western Avenue, Wenatchee, Washington 98801, USA
    J Agric Food Chem 52:5957-63. 2004
    ..Treatment with the antioxidant diphenylamine prior to storage prevented most of the high CO(2)-induced and ultralow O(2)-induced changes in volatile ..
  38. ncbi 1-Methylcyclopropene interactions with diphenylamine on diphenylamine degradation, alpha-farnesene and conjugated trienol concentrations, and polyphenol oxidase and peroxidase activities in apple fruit
    J M R Apollo Arquiza
    Department of Horticulture, Cornell University, Ithaca, New York 14853, USA
    J Agric Food Chem 53:7565-70. 2005
    ..to inhibit ethylene action in apple fruit, but its interactions with existing technologies such as diphenylamine (DPA) for control of superficial scald development in fruit during and after storage is unknown...
  39. ncbi Influence of ethylene action, storage atmosphere, and storage duration on diphenylamine and diphenylamine derivative content of Granny Smith apple peel
    David R Rudell
    Tree Fruit Research Laboratory, Agricultural Research Service, U S Department of Agriculture, 1104 North Western Avenue, Wenatchee, Washington 98801, USA
    J Agric Food Chem 54:2365-71. 2006
    The application of diphenylamine (DPA) to prevent the apple peel disorder superficial scald can result in accumulation of a number of DPA derivatives resulting from C-nitration, C-hydroxylation, O-methylation, and N-nitrosation during ..
  40. ncbi Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901
    Julius Leyton
    Molecular Therapy Group, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom
    Mol Cancer Ther 7:3112-21. 2008
    ..6; P > or = 0.003). In summary, [18F]FLT-PET is a sensitive imaging biomarker for detecting the antiproliferative effect of MEK1/2 inhibition by PD0325901...
  41. ncbi Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice
    Sabrina C Wentz
    Department of Surgery, Indiana University School of Medicine, 1044 W Walnut St R4 039, Indianapolis, IN 46202, USA
    J Gastrointest Surg 12:30-7. 2008
    ..Control and treated HCC demonstrated similar proliferation rates, but apoptosis appeared increased with treatment. MEK targeting is effective HCC chemoprevention, perhaps by lowering the apoptotic threshold...
  42. ncbi Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways
    Paolo Lunghi
    Department of Clinical Sciences, University of Parma, Italy
    Blood 112:2450-62. 2008
    ..These preclinical studies provide the framework for testing PD325901 and ATO combination therapy in clinical trials aimed to improve patient outcome in MM...
  43. pmc 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition
    David B Solit
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 67:11463-9. 2007
    ..The data suggest that [(18)F]FLT PET can effectively image induction of G(1) arrest by MEK inhibitors in mutant BRAF tumors and may be a useful noninvasive method for assessing the early biological response to this class of drugs...
  44. ncbi The ground state of embryonic stem cell self-renewal
    Qi Long Ying
    Center for Stem Cell and Regenerative Medicine, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, ZNI 529, Los Angeles, California 90033, USA
    Nature 453:519-23. 2008
    ..This property may account for their latent tumorigenicity. The delineation of minimal requirements for self-renewal now provides a defined platform for the precise description and dissection of the pluripotent state...
  45. ncbi The role of mitogen-activated ERK-kinase inhibitors in lung cancer therapy
    Alex A Adjei
    Division of Medical Oncology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Clin Lung Cancer 7:221-3. 2005
    ..The most promising approach to date appears to be the inhibition of mitogen-activated ERK kinase or MEK. In this review, the potential utility of MEK inhibitors in the therapy of lung cancer is discussed...
  46. ncbi Development and validation of HPLC methods for the determination of potential extractables from elastomeric stoppers in the presence of a complex surfactant vehicle used in the preparation of parenteral drug products
    Baiming Xiao
    Bristol Myers Squibb Company, Pharmaceutical Research Institute, P O Box 191, New Brunswick, NJ 08903 0191, USA
    J Pharm Biomed Anal 43:558-65. 2007
    ..and validated for potential extractables [zinc dithiocarbamate, 2,6-di-tert-butyl-para-cresol (BHT), octylated diphenylamine antioxidant, sulfur, pentylphenol, and tetrakis(methylene(3,5-di-tert-butyl-4-hydroxyhydro cinnamate))methane] ..
  47. ncbi Reconstitution of Okenone into light harvesting complexes from Allochromatium minutissimum
    O A Toropygina
    Institute of Basic Problems of Biology, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia
    Biochemistry (Mosc) 70:1231-7. 2005
    ..Suppression of this pathway by diphenylamine, an inhibitor of carotenogenesis, yielded nearly carotenoidless complexes preserving their native spectral ..
  48. ncbi Promising core structure for nuclear receptor ligands: design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton
    Kiminori Ohta
    Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Bioorg Med Chem Lett 18:5050-3. 2008
    Novel diphenylamine-type estrogen receptor ligands were designed and synthesized, and their biological activities were evaluated by means of binding assays for estrogen receptor-alpha and -beta and cell proliferation assay using MCF-7 ..
  49. ncbi Non-conjugated, phenyl assisted coupling in through bond electron transfer in a perylenemonoimide-triphenylamine system
    Toby D M Bell
    Department of Chemistry, Katholieke Universiteit Leuven, Insitute for Nanoscale Physics and Chemistry, Celestijnenlaan 200F, 3001, Heverlee, Belgium
    Photochem Photobiol Sci 6:406-15. 2007
    ..The calculations also indicate a strong angle dependence of the total coupling in both isomers. The experimental results are discussed in the context of the high temperature limit of Marcus's theory of non-adiabatic ET...
  50. ncbi Rapid determination of diphenylamine residues in apples and pears with a single multicommuted fluorometric optosensor
    Juan Francisco García-Reyes
    Department of Physical and Analytical Chemistry, Faculty of Experimental Sciences, University of Jaen, Paraje Las Lagunillas, E 23071 Jaén, Spain
    J Agric Food Chem 53:9874-8. 2005
    ..multicommuted system using solid-surface fluorescence spectroscopy has been explored for the determination of diphenylamine in apples and pears...
  51. ncbi Synthesis and characterization of processable multi-walled carbon nanotubes-sulfonated polydiphenylamine graft copolymers
    Kwang Pill Lee
    Department of Chemistry Graduate School, Kyungpook National University, Daegu 702 701, South Korea
    J Nanosci Nanotechnol 7:3386-93. 2007
    Water soluble and processable nanocomposites composed of multi-walled carbon nanotubes (MWNTs) and poly(diphenylamine sulfonic acid) (PDPASA) are synthesized and characterized. Two types of methodologies are adopted...
  52. ncbi Nanostructuring of poly(diphenylamine) inside the galleries of montmorillonite organo clay through self-assembly approach
    Anantha Iyengar Gopalan
    Department of Chemistry Graduate School, Kyungpook National University, Daegu 702 701, South Korea
    J Nanosci Nanotechnol 6:1594-601. 2006
    Hollow spheres of poly(diphenylamine) (PDPA) was prepared by confining PDPA in the galleries of montmorillonite organo clay modified with organoammonium cations (MMT)...
  53. ncbi Degradation of nitrocellulose by fungi
    Nadja Auer
    Fungal Biotechnology Group, University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UK
    Biodegradation 16:229-36. 2005
    ..The physical nature of the NC pellets may have reduced the rate of degradation in comparison with supplying NC in solution in the cultures...
  54. ncbi Thin-layer chromatography analysis of fructooligosaccharides in biological samples
    Katarína Reiffová
    University of P J Safarik, Faculty of Natural Sciences, Institute of Chemistry Sciences, Moyzesova 11, 040 01 Kosice, Slovak Republic
    J Chromatogr A 1110:214-21. 2006
    ..The visualisation of FOSs on chromatograms was performed with mixture of diphenylamine-aniline-phosphoric acid in acetone as primary detection reagent...
  55. ncbi Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter
    Jianjing Cao
    Medicinal Chemistry and Psychobiology Sections, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 47:6128-36. 2004
    ....
  56. ncbi Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum
    Jian Guan
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Med Chem 45:2741-8. 2002
    ..Four aromatic amine ring systems-phenothiazine, iminodibenzyl, iminostilbene, and diphenylamine-were examined...
  57. ncbi Enzymatic treatment of sulfonated aromatic amines generated from reductive degradation of reactive azo dyes
    Mousumi Mani Biswas
    Environmental Engineering, University of Windsor, Ontario, Canada
    Water Environ Res 79:351-6. 2007
    ..For better understanding of the process, enzymatic treatment of two model compounds, diphenylamine (DPA) and 2-amino-8-naphthol-3,6-disulfonic acid (ANDSA), were also studied...
  58. ncbi Functional complementation in Escherichia coli of different phytoene desaturase genes and analysis of accumulated carotenes
    H Linden
    , , Bundesrepublik Deutschland
    Z Naturforsch C 46:1045-51. 1991
    ..The I50 values for flurtamone and diphenylamine to inhibit phytoene desaturation were determined and differential inhibition was observed for diphenylamine.
  59. ncbi Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
    M D Green
    Department of Pharmacology, The University of Iowa, Iwo City, IA 52242, USA
    Drug Metab Dispos 26:507-12. 1998
    ..catalyzes the N-glucuronidation of primary, secondary, and tertiary amine substrates, such as 4-aminobiphenyl, diphenylamine, and cyproheptadine...
  60. ncbi Swelling-activated transport of taurine in cultured gill cells of sea bass: physiological adaptation and pavement cell plasticity
    Martine Avella
    Universite de Nice Sophia Antipolis, 06108 Nice Cedex 02, France
    Am J Physiol Regul Integr Comp Physiol 296:R1149-60. 2009
    ..the following efficiency: 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) > niflumic acid > DIDS = diphenylamine-2-carboxylic acid...
  61. ncbi Potential for bioremediation of agro-industrial effluents with high loads of pesticides by selected fungi
    Panagiotis A Karas
    Department of Biochemistry and Biotechnology, University of Thessaly, Larisa, Greece
    Biodegradation 22:215-28. 2011
    ..the pesticides thiabendazole (TBZ), imazalil (IMZ), thiophanate methyl (TM), ortho-phenylphenol (OPP), diphenylamine (DPA) and chlorpyrifos (CHL)...
  62. ncbi Plastoquinol as a singlet oxygen scavenger in photosystem II
    Jerzy Kruk
    Department of Plant Physiology and Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Biochim Biophys Acta 1777:154-62. 2008
    ..The degradation of both prenyllipids was partially reversed by diphenylamine, a singlet oxygen scavenger...
  63. ncbi Diphenylamine-2-carboxylic acid potentiates the cyclic nucleotides-mediated relaxation of porcine coronary artery: possible involvement of the inhibitory effect on the efflux of cyclic nucleotides
    Tsutomu Nakahara
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Vascul Pharmacol 41:21-5. 2004
    We examined the effect of diphenylamine-2-carboxylic acid (DPC), which has been shown to inhibit the efflux of cyclic nucleotides from vascular smooth-muscle cells, on the relaxant responses to forskolin, an adenylyl cyclase activator, ..
  64. ncbi Pasteurella haemolytica leukotoxin induced apoptosis of bovine lymphocytes involves DNA fragmentation
    Y Sun
    Department of Anatomy, Pathology and Pharmacology, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA
    Vet Microbiol 65:153-66. 1999
    ..After exposure, DNA fragmentation in lymphocytes was quantified colorimetrically by diphenylamine assay and visualized by agarose gel electrophoresis...
  65. ncbi Mutation in a gene encoding anti-sigma factor in A. brasilense confers tolerance to elevated temperature, antibacterial peptide and PEG-200 via carotenoid synthesis
    Mukti Nath Mishra
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, India
    FEMS Microbiol Lett 287:221-9. 2008
    ..Inhibition of carotenoid synthesis by diphenylamine inhibited the ability of the mutant to tolerate all the three stresses...
  66. ncbi Analysis of the headspace composition of smokeless powders using GC-MS, GC-μECD and ion mobility spectrometry
    Monica Joshi
    Department of Chemistry and Biochemistry, International Forensic Research Institute, Florida International University, Miami, FL 33199, United States
    Forensic Sci Int 208:29-36. 2011
    ..The detection of diphenylamine, ethyl and methyl centralite, 2,4-dinitrotoluene, diethyl and dibutyl phthalate by IMS is suggested as a ..
  67. pmc Cyclic AMP inhibits Cl-/HCO3- exchange at the apical membrane of Necturus gallbladder epithelium
    L Reuss
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77550
    J Gen Physiol 90:173-96. 1987
    ..mucosal [Cl-] and [HCO3-] or lowering [Cl-] alone in the presence of a blocker of anion exchange (diphenylamine-2-carboxylate), indicate that elevation of intracellular cAMP inhibited the anion exchanger by approximately ..
  68. ncbi Determination of N,N',N"-triethylenethiophosphoramide and its active metabolite N,N',N"-triethylenephosphoramide in plasma and urine using capillary gas chromatography
    R J van Maanen
    University of Utrecht, Department of Pharmaceutical Analysis, The Netherlands
    J Chromatogr B Biomed Sci Appl 719:103-12. 1998
    ..b>Diphenylamine was used as internal standard. The limit of detection was 1.5 ng/ml for thioTEPA and 2...
  69. ncbi The indirect detection of bleach (sodium hypochlorite) in beverages as evidence of product tampering
    David S Jackson
    Forensic Chemistry Center, U S Food and Drug Administration, Cincinnati, OH 45237, USA
    J Forensic Sci 51:827-31. 2006
    ..hypochlorite on these beverages over a 13-day study period was evaluated using the following techniques: diphenylamine spot test for oxidizing agents, potassium iodide-starch test paper for oxidizing agents, pH, iodometric ..
  70. ncbi Action of physalaemin on the ionic transport across the frog skin
    S Lobasso
    Institute of General Physiology, University of Bari, Italy
    Arch Physiol Biochem 105:329-36. 1998
    ..Furthermore diphenylamine-2-carboxylic acid (DPC, 0...
  71. ncbi Behavioral effects of rimcazole analogues alone and in combination with cocaine
    Jonathan L Katz
    Department of Health and Human Services, Medications Discovery Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Eur J Pharmacol 468:109-19. 2003
    ..and the N-propylphenyl analogues, SH 3-24 ([3-(cis-3,5-dimethyl-4-[3-phenylpropyl]-1-piperazinyl)-propyl]diphenylamine hydrochloride) and SH 3-28 (9-[3-(cis-3,5-dimethyl-4-[3-phenylpropyl]-1-piperazinyl)-propyl]carbazole ..
  72. pmc Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model
    Zi Huan Yang
    The School of Life Science, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 3:e3348. 2008
    ....
  73. ncbi Profiling of compounds and degradation products from the postharvest treatment of pears and apples by ultra-high pressure liquid chromatography quadrupole-time-of-flight mass spectrometry
    Yolanda Pico
    Laboratori de Nutrició i Bromatologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Talanta 81:281-93. 2010
    ..treatments were detected in this set of samples: imazalil (IMZ)/ethoxyquin (EQ) and thiabendazole (TBZ)/diphenylamine (DPA)...
  74. ncbi Ionic mechanism of forskolin-induced liquid secretion by porcine bronchi
    Stephen T Ballard
    Department of Physiology, College of Medicne, University of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Lung Cell Mol Physiol 290:L97-104. 2006
    ..Jv was significantly inhibited by the anion channel blockers 5-nitro-2-(3-phenylpropylamino)benzoic acid, diphenylamine-2-carboxylate, and glibenclamide...
  75. ncbi Involvement of cystic fibrosis transmembrane conductance regulator in mouse sperm capacitation
    Enrique O Hernández-González
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca Morelos 62210, Mexico
    J Biol Chem 282:24397-406. 2007
    ..Interestingly, the addition of a CFTR inhibitor (diphenylamine-2-carboxylic acid; 250 microM) inhibited the capacitation-associated hyperpolarization, prevented ENaC closure,..
  76. ncbi Novel chromogenic substrates with metal chelating properties for the histochemical detection of peroxidasic activity, derived from 3-amino-9-ethylcarbazole (AEC) and 3,6-diamino-9-ethylcarbazole
    R Krieg
    Institute of Anatomy Anatomy II, Friedrich Schiller University Jena, Germany
    Cell Mol Biol (Noisy-le-grand) 46:1191-212. 2000
    ..side-coupling reactions with aromatic amine or phenol-additives exemplified here by means of 4-amino-N,N-diphenylamine. The reagents 4 and 7 are obtainable in a simple in situ synthesis, too, offering in principle a 'chemical ..
  77. ncbi Reactivity of dioxoruthenium(VI) porphyrins toward amines. Synthesis and characterization of bis(arylamine)ruthenium(II), bis(arylamido)- and bis(diphenylamido)ruthenium(IV), and oxo(tert-butylimido)ruthenium(VI) porphyrins
    J S Huang
    Department of Chemistry, The University of Hong Kong, China
    Chemistry 6:334-44. 2000
    ..porphyrins, [Ru(VI)O2(Por)], with p-chloroaniline, trimethylamine, tert-butylamine, p-nitroaniline, and diphenylamine afforded bis(amine)ruthenium(II) porphyrins, [Ru(II)(Por)(L)2] (L-p-ClC6H4NH2, Me3N, Por=TTP, 4-Cl-TPP; L=..
  78. ncbi Absorption of taurocholic acid by the ileum of normal and transgenic DeltaF508 cystic fibrosis mice
    J Hardcastle
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    J Pharm Pharmacol 56:445-52. 2004
    ..by a low mucosal Na(+) concentration, but unaffected by Cl(-)-free conditions, serosal furosemide or mucosal diphenylamine-2-carboxylic acid (DPC)...
  79. ncbi Waste-free chemistry of diazonium salts and benign separation of coupling products in solid salt reactions
    Gerd Kaupp
    Universitat Oldenburg, FB Chemie, Organische Chemie I, Postfach 2503, 26111 Oldenburg, Germany
    Chemistry 8:1395-406. 2002
    ..Solid diazonium salts couple quantitatively with solid diphenylamine and anilines to give the triazenes...
  80. ncbi NaCl and fluid secretion by the intestine of the teleost Fundulus heteroclitus: involvement of CFTR
    W S Marshall
    Department of Biology, St Francis Xavier University, Antigonish, Nova Scotia, Canada B2G 2W5
    J Exp Biol 205:745-58. 2002
    ..22 microequiv cm(-2) h(-1), N=7, P<0.01). Mucosal application of the anion channel blocker 1 mmol l(-1) diphenylamine-2-carboxylate (DPC) after ionomycin + db-cAMP + IBMX treatment significantly reduced serosal-to-mucosal ..
  81. ncbi Ursodeoxycholic acid action on the transport function of the small intestine in normal and cystic fibrosis mice
    J Hardcastle
    Department of Biomedical Science, University of Sheffield, UK
    J Pharm Pharmacol 53:1457-67. 2001
    ..concentration, while the second phase was inhibited by (Cl-)-free conditions, serosal furosemide or mucosal diphenylamine-2-carboxylic acid (DPC), suggesting an initial Na+-dependent bile acid absorption followed by a stimulation of ..
  82. ncbi Diphenylamine-2-carboxylic acid (DPC), Usually an inhibitor of Cl- and non-selective cation channels, inhibits Cl-/HCO3- exchange and opens Cl- and cation conductances in rabbit gallbladder epithelium
    D Cremaschi
    Dipartimento di Fisiologia e Biochimica Generali, Universita degli Studi di Milano, Italy
    Pflugers Arch 442:409-19. 2001
    ..of apical Cl- influx, the anion exchange is shown here to be directly and immediately inhibited by diphenylamine-2-carboxylic acid (DPC) too...
  83. ncbi [Synthesis and photoluminescence of novel terbium(III) ternary complexes with carboxylic acid]
    Xiao ming Ren
    College of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China
    Guang Pu Xue Yu Guang Pu Fen Xi 31:436-9. 2011
    In the present paper, imidazo[5,6-f] phenanthroline(IP), 2-aniline carbonyl benzoic acid (HAB) and 2-diphenylamine carbonyl benzoic acid (HDPAB) were synthesized at room temperature...
  84. ncbi New protocol for the isolation of nitrocellulose from gunpowders: utility in their identification
    María López-López
    University Institute of Research in Police Sciences IUICP, Planta Piloto de Química Fina, Universidad de Alcala, Ctra Madrid Barcelona Km 33 600, Alcala De Henares Madrid, Spain
    Talanta 81:1742-9. 2010
    ..were selected: three extractions with methanol (to remove nitroglycerin, 2,4-dinitrotoluene, ethyl-centralite, diphenylamine, and diphenylamine derivatives); one extraction with dichloromethane (to remove colorants and plasticizers of ..
  85. ncbi Screening of agrochemicals in foodstuffs using low-temperature plasma (LTP) ambient ionization mass spectrometry
    Joshua S Wiley
    Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Analyst 135:971-9. 2010
    ..Thirteen multi-class agricultural chemicals were studied (ametryn, amitraz, atrazine, buprofezin, DEET, diphenylamine, ethoxyquin, imazalil, isofenphos-methyl, isoproturon, malathion, parathion-ethyl and terbuthylazine)...
  86. ncbi Pesticide residues in Italian Ready-Meals and dietary intake estimation
    Michele Lorenzin
    Provincial Agency for Environmental Protection, Trento, Italy
    J Environ Sci Health B 42:823-33. 2007
    ..20 times), procymidone (17), pyrimethanil (7), iprodione (7), cyprodinil (7), fenitrothion (6), diphenylamine (6), chlorpyrifos (6), metalaxyl (5) and chlorpyrifos-methyl (5)...
  87. ncbi A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells
    Céline Auzanneau
    Laboratoire des Biomembranes et Signalisation Cellulaire CNRS UMR 6558, Universite de Poitiers, 40 Avenue du Recteur Pineau, Poitiers, France
    J Biol Chem 278:19230-6. 2003
    ..b>Diphenylamine-2-carboxylic acid and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid blocked the induced currents, and its ..
  88. ncbi Analyses of pesticide residues in fruit-based baby food by liquid chromatography/electrospray ionization time-of-flight mass spectrometry
    Bienvenida Gilbert-López
    Department of Physical and Analytical Chemistry, University of Jaen, 23071 Jaen, Spain
    Rapid Commun Mass Spectrom 21:2059-71. 2007
    ..thiabendazole, imazalil, tridemorph, triadimefon, bitertanol, prochloraz, flutriafol, myclobutanil, iprodione, diphenylamine and procymidone) in fruit-based baby food (multi-fruit jars and juices intended for infant consumption)...
  89. ncbi Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries
    R Robert
    Institute of Cellular Physiology and Biology, UMR 6187, National Centre for Scientific Research, University of Poitiers, Poitiers, France
    Eur Respir J 30:857-64. 2007
    ..following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the ..
  90. ncbi [A new virus of rabbit. II. Study on morphological structure and some physicochemical properties of a strain of rabbit hemorrhagic disease virus]
    H Zheng
    Wuhan Institute of Virology, Academia Sinica
    Wei Sheng Wu Xue Bao 32:198-203. 1992
    ..Viral nucleic acid was extracted from purified virus by using SDS-proteinase K-phenol. Tests with diphenylamine, formaldehyde, and staining with acridine orange as well as the curves of thermal denaturation showed that ..
  91. pmc Synthesis of heterocycles via Pd-ligand controlled cyclization of 2-chloro-N-(2-vinyl)aniline: preparation of carbazoles, indoles, dibenzazepines, and acridines
    Dmitry Tsvelikhovsky
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 132:14048-51. 2010
    The Pd-catalyzed condensation of 2-bromostyrene and 2-chloroaniline derivatives yields stable diphenylamine intermediates, which are selectively converted to five-, six-, or seven-membered heteroaromatics (indoles, carbazoles, acridines, ..
  92. ncbi Oxidative phosphorylation supported by an alternative respiratory pathway in mitochondria from Euglena
    R Moreno-Sanchez
    Departamento de Bioquimica, Instituto Nacional de Cardiologia, Juan Badiano 1, Col Seccion XVI, Tlalpan, Mexico, Mexico
    Biochim Biophys Acta 1457:200-10. 2000
    ..The cyanide-resistant respiration was strongly inhibited by diphenylamine, n-propyl-gallate, salicylhydroxamic acid and disulfiram...
  93. ncbi Barakol extracted from Cassia siamea stimulates chloride secretion in rat colon
    Chatsri Deachapunya
    Department of Physiology, Faculty of Medicine, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand
    J Pharmacol Exp Ther 314:732-7. 2005
    ..4 mM. The barakol-stimulated increase in Isc was inhibited by subsequent treatment with 500 microM diphenylamine-2-carboxylic acid or 400 microM glibenclamide added to the apical solution and 200 microM bumetanide added to ..
  94. ncbi [Biology of two lysogenic phages from Bacillus thuringiensis MZ1]
    Wei Liao
    State Key Laboratory of Biocontrol, Sun Yat Sen Zhongshan University, Guangzhou 510275, China
    Wei Sheng Wu Xue Bao 47:92-7. 2007
    ..It was suggested that both phages DNA be linear dsDNA through the typical absorption curves, reaction with diphenylamine, DNase sensitivity and acridine orange staining...
  95. ncbi K+ current stimulation by Cl- in the midgut epithelium of tobacco hornworm (Manduca sexta). I. Kinetics and effect of Cl(-)-site-specific agents
    W Zeiske
    , , FRG
    J Comp Physiol B 162:331-9. 1992
    ..So-called "Cl(-)-specific" transport inhibitors (frusemide, 9-anthracene carboxylic acid, diphenylamine carboxylic acid and 4,4'-diisothiocyana-to-stilbene-2,2'-disulphonic acid) reduce IK when added to the ..
  96. ncbi Different physiological mechanisms control isovolumetric regulation and regulatory volume decrease in chick embryo cardiomyocytes
    M M Souza
    Department of Cell Biology, Division of Physiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell Biol Int 24:713-21. 2000
    ..Potassium channel blockers, quinidine and Ba(2+), and the chloride channel blocker, diphenylamine-2-carboxylate (DPC), compromise IVR in our model...
  97. ncbi Potentiation of oxidative damage to rat red blood cells by the concurrent presence of t-butyl hydroperoxide and bromotrichloromethane
    M Sano
    Laboratory of Health Science, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Toxicol Environ Health 43:339-50. 1994
    ..The inhibition of lipid peroxidation by diphenylamine (which reacts with alkoxyl radicals but not peroxyl radicals) suggests an important role of alkoxyl radicals...
  98. ncbi [Induced apoptosis and mechanism of endosulfan in mouse germ cells]
    Nan qi Ren
    College of Civil Environmental Engineering, Harbin University of Technology, Harbin 150090, China
    Huan Jing Ke Xue 29:386-90. 2008
    ..LCSM), DNA ladder detected by electricity swims, and increasing of DNA degeneration rate measured through diphenylamine (p < 0.01)...
  99. ncbi Development and validation of spectrophotometric methods for estimating amisulpride in pharmaceutical preparations
    Sangita Sharma
    Department of Chemistry, Hemchandracharya North Gujarat University, Patan 384265, Gujarat, India
    Anal Sci 26:485-9. 2010
    ..and hydrochloric acid, followed by coupling with N-(1-naphthyl)ethylenediamine dihydrochloride (Method A), diphenylamine (Method B), beta-naphthol in an alkaline medium (Method C), resorcinol in an alkaline medium (Method D) and ..
  100. ncbi Quantity of DNA in the organs of adult Swiss male mice after AET and MEA treatment
    J Manowska
    Department of Animal Physiology, Jagiellonian University, Cracow, Poland
    Acta Physiol Hung 74:315-9. 1989
    ..means of Burton's method, which is based on the estimation of deoxiribose content in the colour reaction with diphenylamine. The injection of AET and MEA did not distinctly influence the DNA content in the organs of mice...
  101. ncbi Enzymatic assay of gamma-cystathionase activity using pyruvate oxidase-peroxidase sequential reaction
    Yuki Ogasawara
    Department of Environmental Biology, Meiji Pharmaceutical University 2 522 1, Noshio, Kiyose, Tokyo 204 8588, Japan
    J Biochem Biophys Methods 51:139-50. 2002
    ..absorbance increases with the oxidized color of a leuco dye, N-(carboxymethylamino)-4,4'-bis (dimethylamino)-diphenylamine at 727 nm is proportional to the gamma-cystathionase activity...

Research Grants13

  1. CHLORIDE CHANNELS WITH PHOTOAFFINITY PROBES
    Bruce Branchini; Fiscal Year: 1990
    ..Compound I is an optimized version of the basic structure diphenylamine-2-carboxylate, an agent that blocks chloride ion transport at apical sites on bovine tracheal epithelia, the ..
  2. International Network and Registry for TMA
    Howard Trachtman; Fiscal Year: 2007
    ..These include essential hypertension, diabetes, hyperlipidemia, myocardial infarction, and chronic kidney disease. [unreadable] [unreadable]..
  3. Enhanced Drug Access to Eye Tissues
    John Tomich; Fiscal Year: 2004
    ..These proof-of-concept studies are directed toward the treatment of acute infections of the eye through the instillation of drugs in drops rather than the current approach using injections. ..
  4. Antitumor Mechanisms of SRC Inhibitors in Lung Cancer
    Eric Haura; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  5. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2006
    ..The infrastructure that is established for the performance of this R21/R33 project should prove useful for the efficient assessment of additional novel therapies that will be developed in the future for patients with primary FSGS. ..
  6. Osteoblast Derived Pathogenic Factors in Hyp Mice
    Norimoto Yanagawa; Fiscal Year: 2005
    ..abstract_text> ..
  7. Human monoclonal antibody therapy for HUS
    Howard Trachtman; Fiscal Year: 2004
    ..abstract_text> ..
  8. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  9. Synthetic Peptide Modulators of Paracellular Conductance
    John Tomich; Fiscal Year: 2002
    ..In a Phase II application drug uptake studies will be monitored using both in vitro and in vivo systems. ..
  10. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Our long-term goal is to delineate the multifunctional roles of CP in brain fluid homeostasis. ..
  11. ROLE OF ORDERED HELICAL SEGMENTS IN MEMBRANE PROTEINS
    John Tomich; Fiscal Year: 2002
    ....
  12. Channel Replacement Therapy for Cystic Fibrosis
    John Tomich; Fiscal Year: 2002
    ..Non-medical, modified-membrane applications in ion exchange and batteries may also be achievable. ..
  13. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Translation: Ap is an expedient marker to analyze aging effects on ISF-CSF relationships, and the compromised solute clearance by malfunctioning barrier systems. This sheds light on neurodegeneration. ..