- Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
William E Klunk
Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
Ann Neurol 55:306-19. 2004
..This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects...
- ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
Cancer Res 68:3421-8. 2008
..The oral efficacy of ABT-263 should provide dosing flexibility to maximize clinical utility both as a single agent and in combination regimens...
- Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
Milos D Ikonomovic
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Brain 131:1630-45. 2008
..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden...
- Frequent amyloid deposition without significant cognitive impairment among the elderly
Howard Jay Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Neurol 65:1509-17. 2008
- The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core
William J Jagust
Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA
Alzheimers Dement 6:221-9. 2010
..This is a progress report of the Alzheimer's Disease Neuroimaging Initiative (ADNI) positron emission tomography (PET) Core...
- Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
L L Remsing Rix
Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
Leukemia 23:477-85. 2009
..Finally, bosutinib is the first kinase inhibitor shown to target CAMK2G, recently implicated in myeloid leukemia cell proliferation...
- In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells
Department of Clinical Medicine, S Gerardo Hospital University of Milano Bicocca, Monza, Italy
Cancer Res 66:11314-22. 2006
..Modeling considerations attribute the superior activity of SKI-606 to its ability to bind a conformation of Bcr-Abl different from imatinib...
- Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib
Jorge E Cortes
M D Anderson Cancer Center, Houston, TX, USA
Blood 118:4567-76. 2011
..These data suggest bosutinib is effective and tolerable in patients with chronic phase imatinib-resistant or imatinib-intolerant CML. This trial was registered at http://www.clinicaltrials.gov as NCT00261846...
- Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
Clifford R Jack
Clifford R Jack, Mayo Clinic, Diagnostic Radiology, 200 First Street SW, Rochester, MN 55905, USA
Brain 132:1355-65. 2009
..This model implies a complimentary role for MRI and PIB imaging in Alzheimer's disease, with each reflecting one of the major pathologies, amyloid dysmetabolism and neurodegeneration...
- Performance characteristics of amyloid PET with florbetapir F 18 in patients with alzheimer's disease and cognitively normal subjects
Abhinay D Joshi
Avid Radiopharmaceuticals, Inc, Philadelphia, PA 19104, USA
J Nucl Med 53:378-84. 2012
..In a separate set of subjects (AD, n = 10; YHCs, n = 10), test-retest reliability was evaluated by comparing intrasubject visual read ratings and SUVrs for 2 PET images acquired within 4 wk of each other...
- Bax and Bcl-xL exert their regulation on different sites of the ceramide channel
Meenu N Perera
Department of Biology, University of Maryland, College Park, MD 20742, USA
Biochem J 445:81-91. 2012
..Molecular docking simulations of the lowest-energy binding poses of ceramides and Bcl-xL inhibitors to Bcl-xL were consistent with the results of our functional studies and propose potential binding modes...
- Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29425, USA
J Biol Chem 278:13775-83. 2003
..In conclusion, these results 1) show that nSMase2 is a structural gene for nSMase, 2) suggest that nSMase2 acts as a bona fide N-SMase in cells, and 3) implicate nSMase2 in the regulation of cell growth and cell signaling...
- Novel aspects of therapy with the dual Src and Abl kinase inhibitor bosutinib in chronic myeloid leukemia
Gunhild Keller-V Amsberg
Klinik für Hämatologie und Onkologie mit der Sektion Pneumologie, Onkologisches Zentrum, Universitäts Klinikum Hamburg Eppendorf, Hamburg, Germany
Expert Rev Anticancer Ther 12:1121-7. 2012
..This may be causative for its favorable hematologic toxicity profile. In this review, the authors give an overview on the mechanism of action and currently available preclinical and clinical data for bosutinib in CML...
- Degradation of aniline by newly isolated, extremely aniline-tolerant Delftia sp. AN3
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, P R China
Appl Microbiol Biotechnol 58:679-82. 2002
..Based on the results obtained, a pathway for the degradation of aniline by Delftiasp. AN3 was proposed. The importance of the strain to the operation of municipal wastewater treatment plants is discussed...
- 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
Juha O Rinne
Turku PET Centre and Clinical Research Services Turku, University of Turku and Turku University Hospital, Turku, Finland
Lancet Neurol 9:363-72. 2010
..We used (11)C-PiB PET to investigate whether bapineuzumab, a humanised anti-amyloid-beta monoclonal antibody, would reduce cortical fibrillar amyloid-beta load in patients with Alzheimer's disease...
- SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells
Molecular Medicine, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Mol Cancer Ther 7:1185-94. 2008
..Our findings indicate that SKI-606 inhibits signaling pathways involved in controlling tumor cell motility and invasion, suggesting that SKI-606 is a promising therapeutic for breast cancer...
- Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent--a pilot study
Kun Ju Lin
Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan
Nucl Med Biol 37:497-508. 2010
..This pilot study reports the safety, biodistribution, and radiation dosimetry of [(18)F]AV-45 in human subjects...
- Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging
V B Gupta
Centre of Excellence for Alzheimer s Disease Research and Care, School of Exercise Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Neurology 76:1091-8. 2011
..The major objective of this cross-sectional study was to investigate total plasma apoE as well as levels of the apoE4 form in a large, highly characterized cohort which included both healthy controls and participants with early-stage AD...
- A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth
Vita M Golubovskaya
Department of Surgery, UF Shands Cancer Center, Department of Pathology and Laboratory Medicine, University of Florida, Gainesville, Florida 32610 0245, USA
J Med Chem 51:7405-16. 2008
..Furthermore, 14 effectively caused breast tumor regression in vivo. Thus, targeting the Y397 site of FAK with 14 inhibitor can be effectively used in cancer therapy...
- Conducting polymers in electronic chemical sensors
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
Nat Mater 2:19-24. 2003
..Our aim here is to discuss the usability of conducting polymers in both types of electronic applications in light of these two parameters...
- SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models
Jennifer M Golas
Department of Oncology, Wyeth Research, Pearl River, New York 10965, USA
Cancer Res 65:5358-64. 2005
..These results support development of SKI-606 as a therapeutic agent for treatment of colorectal cancer...
- SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling
Addolorata Maria Luce Coluccia
Department of Experimental Oncology, National Cancer Institute, Milan, Italy
Cancer Res 66:2279-86. 2006
- Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
Keith A Johnson
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
Ann Neurol 62:229-34. 2007
- Degradation of 3,4-dichloro- and 3,4-difluoroaniline by Pseudomonas fluorescens 26-K
Vassili M Travkin
G K Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino, Moscow Region, Russia
J Environ Sci Health B 38:121-32. 2003
..08 micromol/min/mg of protein) was found in the cell-free extract of biomass grown on 3,4-DFA. 3-Fluoro-4-hydroxyaniline as intermediate was found in this cell-free extract...
- Biodegradation of 4-chloroaniline by bacteria enriched from soil
Alisa S Vangnai
Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
FEMS Microbiol Lett 268:209-16. 2007
..These results suggest that these isolates have a potential use for bioremediation of the site contaminated with 4-chloroaniline...
- Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases
M A Battistone
Instituto de Biologia y Medicina Experimental, IBYME CONICET, Ciudad Autonoma de Buenos Aires, C1428ADN Buenos Aires, Argentina
Mol Hum Reprod 19:570-80. 2013
- Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia
Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
J Pharmacol Exp Ther 331:827-35. 2009
..These data demonstrate that the novel Src kinase inhibitors provide effective treatment against ischemic conditions within a clinically relevant therapeutic window and may constitute a viable therapy for acute stroke...
- SEA0400, a novel Na+/Ca2+ exchanger inhibitor, reduces calcium overload induced by ischemia and reperfusion in mouse ventricular myocytes
Department of Physiology, Capital University of Medical Sciences, Beijing, China
Physiol Res 56:17-23. 2007
..The results suggested that SEA0400 is a potent NCX inhibitor, which can protect mouse cardiac myocytes from Ca2+ overload during I/R injuries...
- Pathway and evolutionary implications of diphenylamine biodegradation by Burkholderia sp. strain JS667
Kwanghee A Shin
School of Civil and Environmental Engineering, Georgia Institute of Technology, 311 Ferst Dr, Atlanta, GA 30332 0512, USA
Appl Environ Microbiol 75:2694-704. 2009
..Both the sequence similarity and the gene organization suggest that the DPA degradation pathway evolved recently by the recruitment of two gene clusters that encode the DPA dioxygenase and aniline degradation pathway...
- Biodegradation potential of pure and mixed bacterial cultures for removal of 4-nitroaniline from textile dye wastewater
Department of Environmental Sciences, PMAS Arid Agriculture University, Rawalpindi 46300, Pakistan
Water Res 43:1110-6. 2009
..Our findings show that enrichment cultures from activated sludge can be effective for the removal of dyes and their toxic intermediates, and that treatment may best be accomplished using an anaerobic-aerobic process...
- Prostaglandin E2 activates channel-mediated calcium entry in human erythrocytes: an indication for a blood clot formation supporting process
Institute for Molecular Cell Biology, Faculty of Medicine, Building 61, Saarland University, 66421 Homburg Saar, Germany
Thromb Haemost 92:1269-72. 2004
..Therefore, we conclude that the PGE(2) responses of red blood cells described here reveal a direct and active participation of erythrocytes in blood clot formation...
- Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action
Universite McGill, Departement de Psychiatrie, Bâtiment de Recherche et de Formation, Bureau 207, 1033 Avenue des Pins Ouest, Montreal, QC, H3A 1A1 Canada
Neuron 55:712-25. 2007
..These findings point out 5-HT(4) receptor agonists as a putative class of antidepressants with a rapid onset of action...
- Reduction by SEA0400 of myocardial ischemia-induced cytoplasmic and mitochondrial Ca2+ overload
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Miyama 2 2 1 Funabashi, Chiba 274 8510, Japan
Eur J Pharmacol 543:108-15. 2006
..SEA0400 significantly delayed these changes. These results suggest that SEA0400 maintains mitochondrial function and tissue ATP content during ischemia through the inhibition of cytoplasmic and mitochondrial Ca(2+) overload...
- Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease
Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Federal Republic of Germany
Biol Psychiatry 68:879-84. 2010
..Only few data have been published on in vivo longitudinal changes of amyloid load in Alzheimer's disease (AD) patients, with conflicting results. Therefore, little is known about the factors that influence these changes...
- Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy
Department of Medical Oncology, Centre Rene Gauducheau, Nantes Saint Herblain, France
Ann Oncol 23:610-7. 2012
..This phase II study evaluated single-agent bosutinib in pretreated patients with locally advanced or metastatic breast cancer...
- Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy
Program of Cell Death and Apoptosis, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
PLoS ONE 6:e24102. 2011
- Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells
Nicola Antonio Martino
Department of Animal Production, Faculty of Biotechnological Sciences, University of Bari, Valenzano, Bari, Italy
PLoS ONE 6:e17714. 2011
..The involvement of CaSR on observed cell response was analyzed at both the mRNA and protein level...
- Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer's disease
Victor L Villemagne
Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia
Eur J Nucl Med Mol Imaging 39:983-9. 2012
..The purpose of this analysis was to compare data on cortical Aβ deposition in subjects who had undergone both (11)C-PiB (PiB) and (18)F-florbetaben (FBB) PET imaging...
- Recent advances in polyaniline based biosensors
Department of Science and Technology Centre on Biomolecular Electronics, Biomedical Instrumentation Section, Materials Physics and Engineering Division, National Physical Laboratory, Council of Scientific and Industrial Research, Dr KS Krishnan Marg, New Delhi 110012, India
Biosens Bioelectron 26:2811-21. 2011
..Efforts have been made to discuss and explore various characteristics of PANI responsible for direct electron transfer leading towards fabrication of mediator-less biosensors...
- Metabolism of 2-chloro-4-nitroaniline via novel aerobic degradation pathway by Rhodococcus sp. strain MB-P1
Institute of Microbial Technology, Council of Scientific and Industrial Research, Chandigarh, India
PLoS ONE 8:e62178. 2013
..This is the first report showing 2-C-4-NA degradation and elucidation of corresponding metabolic pathway by an aerobic bacterium...
- ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
Global Pharmaceutical Research and Development, Abbott Laboratories, Building AP3 105, 100 Abbott Park Road, Abbott Park, IL 60064 6074, USA
Mol Cancer Ther 7:3265-74. 2008
..These data suggest that combination of ABT-263 and rapamycin or its analogues represents a promising therapeutic strategy for the treatment of lymphoma...
- Surface-enhanced Raman scattering on tunable plasmonic nanoparticle substrates
J B Jackson
Department of Physics and Astronomy, Laboratory of Nanophotonics, and Rice Quantum Institute, Rice University, Houston, TX 77005, USA
Proc Natl Acad Sci U S A 101:17930-5. 2004
..SERS enhancements as large as 2.5 x 10(10) on Ag nanoshell films for the nonresonant molecule p-mercaptoaniline are measured...
- Use of florbetapir-PET for imaging beta-amyloid pathology
Christopher M Clark
Avid Radiopharmaceuticals, Philadelphia, Pennsylvania, USA
JAMA 305:275-83. 2011
..The ability to identify and quantify brain β-amyloid could increase the accuracy of a clinical diagnosis of Alzheimer disease...
- Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines
Stephen K Tahir
Global Pharmaceutical Product Research Division, Abbott Laboratories, Abbott Park, Illinois 60064 6099, USA
Mol Cancer Ther 9:545-57. 2010
..This study leverages global expression data to identify key gene expression patterns for sensitivity to ABT-263 in SCLC and leukemia/lymphoma and may provide guidance in the selection of patients in future clinical trials...
- Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
Christopher C Rowe
Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, Victoria, Australia
Neurobiol Aging 31:1275-83. 2010
- A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats
Neuroscience Research, Abbott Laboratories, R4PM, AP9 1, 100 Abbott Park Rd, Abbott Park, IL 60064 6118, USA
J Pharmacol Exp Ther 324:1204-11. 2008
..However, Na(v)1.8 sodium channels on central terminals seem to be key to the modulation of spontaneous firing in SNL rats...
- Consequence of one-electron oxidation and one-electron reduction for aniline
Ewa D Raczyńska
Department of Chemistry, Warsaw University of Life Sciences SGGW, ul Nowoursynowska 159C, 02 776 Warszawa, Poland
J Mol Model 17:3229-39. 2011
..The change of the tautomeric preferences for reduced aniline may partially explain the origin of the CH tautomers for reduced nucleobases (cytosine, adenine, and guanine)...
- Imaging amyloid deposition in Lewy body diseases
S N Gomperts
Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 71:903-10. 2008
..In addition to widespread distribution of Lewy bodies, both diseases have variable burdens of neuritic plaques and neurofibrillary tangles characteristic of Alzheimer disease (AD)...
- Intercellular communication mediated by the extracellular calcium-sensing receptor
A M Hofer
Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massahusetts 02115, USA
Nat Cell Biol 2:392-8. 2000
..The CaR may therefore mediate a universal form of intercellular communication that allows cells to be informed of the Ca2+-signalling status of their neighbours...
- A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
Michael F Jarvis
Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
Proc Natl Acad Sci U S A 104:8520-5. 2007
..These data demonstrate that acute and selective pharmacological blockade of Na(v)1.8 sodium channels in vivo produces significant antinociception in animal models of neuropathic and inflammatory pain...
- Chromosome-encoded gene cluster for the metabolic pathway that converts aniline to TCA-cycle intermediates in Delftia tsuruhatensis AD9
Department of Microbiology, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie, Beijing 100081, P R China
Microbiology 151:3435-46. 2005
..The tad gene cluster showed significant similarity in nucleotide sequence and genetic organization to the plasmid-encoded aniline degradation gene cluster of Pseudomonas putida UCC22...
- The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
Cancer Chemother Pharmacol 66:869-80. 2010
..This study was designed to test the ability of the Bcl-2 family inhibitor ABT-263 to potentiate commonly used chemotherapeutic agents and regimens in hematologic tumor models...
- Genetic diversity among 3-chloroaniline- and aniline-degrading strains of the Comamonadaceae
Laboratory of Microbial Ecology and Technology, Ghent University, B-9000 Ghent, Belgium
Appl Environ Microbiol 67:1107-15. 2001
..1 and P. putida UCC22 were only about 83% identical to the other sequences. Northern hybridization revealed that the tdnQ gene is transcribed only in the presence of aniline and not when only 3-CA is present...
- Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias
Victor L Villemagne
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
J Nucl Med 52:1210-7. 2011
- High-rate biodegradation of 3- and 4-nitroaniline
Fraunhofer Management GmbH, Germany
Chemosphere 39:2325-46. 1999
..Partial nitrification, also occurred. After gradual adaptation, the bacteria also degraded 3-NA and 4-NA simultaneously in this system. Additional batch tests showed, that 3-NA can serve as the sole source of carbon, nitrogen and energy...
- Activity correlation imaging: visualizing function and structure of neuronal populations
Department of Neurophysiology and Cellular Biophysics, University of Gottingen, Gottingen, Germany
Biophys J 96:3801-9. 2009
..This method, yielding both functional and structural information of neuronal populations, will open up unprecedented possibilities for the investigation of neuronal networks...
- Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK channels
Zentrum für Physiologie und Pathophysiologie, Abteilung Neuro und Sinnesphysiologie, Georg August Universitat Gottingen, Gottingen, Germany
J Neurophysiol 94:1091-103. 2005
..Accordingly, ionic disregulation and the loss of membrane potential occur later or might even be prevented during short-term insults. Therefore well-directed oxidation of SH groups could mediate neuroprotection...
- In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia
M A Burack
Department of Neurology and Pediatrics, 601 Elmwood Avenue, Box 673, University of Rochester Medical Center, Rochester, NY 14642, USA
Neurology 74:77-84. 2010
..To investigate the specificity of in vivo amyloid imaging with [(11)C]-Pittsburgh Compound B (PIB) in Parkinson disease dementia (PDD)...
- Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia
Gil D Rabinovici
Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
Ann Neurol 64:388-401. 2008
- Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models
S K Joshi
Abbott Laboratories, Neuroscience Research, Abbott Park, Illinois, USA
J Pain 10:306-15. 2009
..Using such a combination strategy to produce analgesia may potentially provide an improved therapeutic separation from unwanted in vivo side effects associated with blockade of either Nav1.8 or TRPV1 alone...
- Calcium imaging of individual erythrocytes: problems and approaches
Institute for Molecular Cell Biology, Faculty of Medicine, Saarland University, 66421 Homburg Saar, Germany
Cell Calcium 39:13-9. 2006
..Our results emphasize that in erythrocytes measurements of intracellular calcium are reliably possible with Fluo-4 and that other indicators, especially those requiring UV-excitation, appear less favourable...
- Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells
Dept of Endocrinology, Metabolism, and Hematological Oncology, Shimane Univ School of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
Am J Physiol Endocrinol Metab 288:E608-16. 2005
..This suggests that the CaR may be involved in osteoblastic differentiation...
- Nerve-highlighting fluorescent contrast agents for image-guided surgery
Summer L Gibbs-Strauss
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
Mol Imaging 10:91-101. 2011
..These results lay the foundation for the development of ideal nerve-highlighting fluorophores for image-guided surgery...
- APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
John C Morris
Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
Ann Neurol 67:122-31. 2010
..To examine interactions of apolipoprotein E (APOE) genotype with age and with in vivo measures of preclinical Alzheimer disease (AD) in cognitively normal aging...
- Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
Clayton A Wiley
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Arch Neurol 66:60-7. 2009
..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood...
- Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
Neurobiol Dis 32:412-9. 2008
..MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage...
- Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line
Endocrine-Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Cell Physiol 280:C382-93. 2001
..5 microM), but not its less active stereoisomer NPS S-467 (0.5 microM), activate an outward K+ channel in MG-63 cells, strongly suggesting that the CaR in MG-63 cells is not only expressed but is functionally active...
- Constitutive expression of catABC genes in the aniline-assimilating bacterium Rhodococcus species AN-22: production, purification, characterization and gene analysis of CatA, CatB and CatC
Division of Life Science, Graduate School of Science and Technology, Kobe University, Rokko, Kobe 657 8501, Japan
Biochem J 393:219-26. 2006
..Based on these data, we concluded that the bacterium constitutively transcribed the catABC genes and translated its mRNA into CatA, CatB and CatC...
- Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
J Neurosci 27:10957-68. 2007
- An update on dual Src/Abl inhibitors
Dipartimento di Scienze Farmaceutiche, University of Genoa, Viale Benedetto XV 3, I 16132 Genova, Italy
Future Med Chem 4:799-822. 2012
..This review is an update on the most important dual inhibitors already in clinical trials and includes information regarding compounds that have appeared in the literature in recent years...
- Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor
GlaxoSmithKline R and D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
Bioorg Med Chem Lett 21:6188-94. 2011
..GSK143 is a potent and highly selective SYK inhibitor showing good efficacy in the rat Arthus model...
- Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells
Institute of Nephrology Department of Medicine, University G D Annunzio, Chieti Pescara, Italy
PLoS ONE 7:e30682. 2012
..Although it has been postulated that calcimimetics may have a direct effect on CaSR in the blood vessels, further studies are needed to elucidate their vascular CaSR-dependent versus CaSR-independent effects...
- Enzymatically synthesized polyaniline layer for extension of linear detection region of amperometric glucose biosensor
NanoTechnas Center of Nanotechnology and Material Science, Faculty of Chemistry, Vilnius University, Naugarduko 24, 03225 Vilnius, Lithuania
Biosens Bioelectron 26:790-7. 2010
..An increase in the upper detection limit, optimal pH region for operation and stability of GOx based electrode modified by PANI was detected when comparing that of an unmodified GOx-electrode...
- Biodegradation pathways of chloroanilines by Acinetobacter baylyi strain GFJ2
International Postgraduate Program in Environmental Management, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand
J Hazard Mater 186:1300-7. 2011
..baylyi strain GFJ2 in bioremediation and waste treatment, and the kinetic data provide the insights into the degradation mechanism, dynamics and possible limitations of the biodegradation which include substrate and product inhibitions...
- Superparamagnetic Fe3O4 nanoparticles as catalysts for the catalytic oxidation of phenolic and aniline compounds
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing, China
J Hazard Mater 167:560-6. 2009
..and reusability, also showed excellent catalysis ability to eliminate some substituted phenolic and aniline compounds from solution...
- Biological transformation pathways of 2,4-dinitro anisole and N-methyl paranitro aniline in anaerobic fluidized-bed bioreactors
William E Platten
Civil and Environmental Engineering Department, University of Cincinnati, Cincinnati, OH 45221, USA
Chemosphere 81:1131-6. 2010
..The AFBB technology was shown here to be an effective means of removing the new munitions, but produce secondary compounds that could potentially be just as harmful and require further study...
- Alcohol vapours sensor based on thin polyaniline salt film and quartz crystal microbalance
Mohamad M Ayad
Department of Chemistry, University of Tanta, Tanta, Egypt
Talanta 78:1280-5. 2009
..The sensor shows a good reproducibility and reversibility. The diffusion and diffusion coefficient (D) of different alcohols vapour were determined. It was found that the sensor follows Fickian kinetics...
- Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles
D H Boschelli
Chemical Sciences and Oncology, Wyeth Ayerst Research, 401 North Middletown Road, Pearl River, New York 10965, USA
J Med Chem 44:822-33. 2001
..Compound 25, which contains a 3-morpholinopropoxy group, had an IC(50) of 3.8 nM in the Src enzymatic assay and an IC(50) of 940 nM for the inhibition of Src-dependent cell proliferation...
- Persistence of chlorpyrifos, fenamiphos, chlorothalonil, and pendimethalin in soil and their effects on soil microbial characteristics
B Kumar Singh
Department of Biological Sciences, Imperial College at Silwood Park, Ascot, Berks SL5 7PY, United Kingdom
Bull Environ Contam Toxicol 69:181-8. 2002
- Polyaniline synthesis and its biosensor application
Zarini Muhammad Tahir
Biosystems Engineering, Michigan State University, East Lansing, MI 48824, USA
Biosens Bioelectron 20:1690-5. 2005
..Further modification could be implemented to evaluate the biosensor as a rapid diagnostic device to detect other infectious disease outbreaks in livestock population...
- Calcimimetic and calcilytic drugs: just for parathyroid cells?
E F Nemeth
NPS Pharmaceuticals, Inc, 30 College Street, Suite 301, Toronto, Ont, Canada
Cell Calcium 35:283-9. 2004
- Degradation of dichloroaniline isomers by a newly isolated strain, Bacillus megaterium IMT21
Xie Feng Yao
Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects, Ministry of Agriculture, Nanjing 210095, China
Microbiology 157:721-6. 2011
..These five DCA isomers were degraded via two different routes. 2,3-, 2,4- and 2,5-DCA were degraded via previously unknown dichloroaminophenol metabolites, whereas 3,4- and 3,5-DCA were degraded via dichloroacetanilide...
- SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
Jennifer M Golas
Departments of Oncology, Wyeth Research, Pearl River, New York 10965, USA
Cancer Res 63:375-81. 2003
..Once daily oral administration of this compound at 100 mg/kg for 5 days causes complete regression of large K562 xenografts in nude mice...
- Acidity of anilines: calculations vs experiment
Institute of Chemistry, University of Tartu, 14a Ravila St, 50411 Tartu, Estonia
J Phys Chem A 115:10335-44. 2011
..The method proved to be rather accurate for showing pK(a) trends (R(2)=0.980 in DMSO). However, the predicted absolute pK(a) values were all somewhat lower (rmsd=2.49 kcal·mol(-1)) than the respective experimental values...
- A kinetic study on the degradation of p-nitroaniline by Fenton oxidation process
Jian Hui Sun
College of Chemistry and Environmental Sciences, Henan Normal University, Henan Key Laboratory for Environmental Pollution Control, Xinxiang, Henan 453007, PR China
J Hazard Mater 148:172-7. 2007
..Based on the rate constants obtained at different temperatures, the empirical Arrhenius expression of PNA degradation was derived. The derived activation energy for PNA degradation by Fenton oxidation is 53.96 kJ mol(-1)...
- Simultaneous determination of five nitroaniline and dinitroaniline isomers in wastewaters by solid-phase extraction and high-performance liquid chromatography with ultraviolet detection
MOE Key Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China
Chemosphere 81:430-5. 2010
..5 x 10(-9)M for 4-nitroaniline and 2,4-dinitroaniline. The proposed method was applied to determine the five isomers in real samples of acidic wastewater and printing and dyeing wastewater...
- CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects
Department of Radiology, University of California, San Francisco, 94143, USA
Cereb Cortex 22:1993-2004. 2012
- Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid
Xiao Jia Yin
School of Pharmacy, Nanjing Medical University, Nanjing 210029, China
Molecules 15:4261-6. 2010
..The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC...
- Optimization of automated radiosynthesis of [18F]AV-45: a new PET imaging agent for Alzheimer's disease
Key Laboratory of Radiopharmaceuticals, Beijing Normal University, Ministry of Education, Beijing, 100875, PR China
Nucl Med Biol 37:917-25. 2010
..We report herein an optimal [(18)F]fluorination, de-protection condition and fully automated radiosynthesis of [(18)F]AV-45 ([(18)F]5) on a radiosynthesis module (BNU F-A2)...
- Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats
Department of Pediatrics, University of Heidelberg, Germany
J Am Soc Nephrol 17:655-62. 2006
..1+/-4 versus 32.5+/-1.4 mmol/kg; P=0.01). The calcimimetic R-568 causes an initial BP increase in sham-operated and uremic rats, which in uremic rats is followed by a marked and sustained antihypertensive effect...
- Calcimimetic NPS R-568 induces hypotensive effect in spontaneously hypertensive rats
Laboratory of Pathophysiology, Medical University of Gdansk, ul Tuwuma 15, 80 210 Gdansk, Poland
Am J Hypertens 18:364-71. 2005
..Parathyroidectomy decreases blood pressure in these rats and in patients. The present study determined whether phPTX induced by calcimimetics decreases mean arterial blood pressure (MAP) in hypertensive rats...
- Myeloperoxidase is a key regulator of oxidative stress mediated apoptosis in myeloid leukemic cells
Division of Hematology, Department of Internal Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Clin Cancer Res 13:5436-45. 2007
..This study aimed to further examine the mechanism of ROS-mediated apoptosis induced by EGCG and its relationship to the heme enzyme myeloperoxidase (MPO)...
- Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
Chester A Mathis
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Med Chem 46:2740-54. 2003
..The encouraging in vitro and in vivo properties of [(11)C]6-OH-BTA-1 support the choice of this derivative for further evaluation in human subject studies of brain Abeta deposition...
- Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study
INSERM, U1077, Caen 14000, France
Brain 135:2126-39. 2012
..Furthermore, this study identified the existence of Pittsburgh compound 'accumulators' and 'non-accumulators', notably within the Pittsburgh compound B-negative group, which may be a relevant concept for future studies...
- Retinoic acid induced suicidal erythrocyte death
Olivier M Niemoeller
Department of Physiology, University of Tuebingen, Tubingen, Germany
Cell Physiol Biochem 21:193-202. 2008
..The eryptosis could participate in the accelerated clearance of parasitized erythrocytes from circulating blood following treatment with retinoids...
- The influence of suspended particles on the acute toxicity of 2-chloro-4-nitro-aniline, cadmium, and pentachlorophenol on the valve movement response of the zebra mussel (Dreissena polymorpha)
Zoological Institute of the University of Cologne, Department of General Ecology and Limnology, , Germany
Arch Environ Contam Toxicol 40:497-504. 2001
..The results are discussed with respect to the physiology of the organisms and the bioavailability of toxicants, as well as to the consequences these results may have under field conditions...
- Signal transduction in red blood cells of the lizards Ameiva ameiva and Tupinambis merianae (Squamata, Teiidae)
F H Beraldo
Departamento de Fisiologia, , , , Brazil
Cell Calcium 29:439-45. 2001
..Finally, the purinergic agonist ATP triggers a rapid and transient increase of [Ca2+]c in the cells from both lizard species, mostly by mobilization of the cation from internal stores...
- The new role of calcimimetics as vasculotropic agents
Division of Nephrology, Saint Louis Veterans Affairs Medical Center, Saint Louis, Missouri, USA
Kidney Int 75:9-12. 2009
..Koleganova et al. describe a novel role for calcimimetics as vasculotropes, which provides the impetus for further studies to characterize their effects on vascular biology...
- Acute cardiovascular effects of the calcimimetic R-568 and its enantiomer S-568 in rats
Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany
Pediatr Nephrol 24:1385-9. 2009
..The calcimimetic R-568 exerts acute, CaSR-independent, hypotensive effects via vasodilation and negative chronotropy at concentrations exceeding those required for modulation of PTH secretion...
- Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes
C L Tu
Department of Medicine, University of California San Francisco and Endocrine Research Unit, Veterans Affairs Medical Center 94121, USA
J Invest Dermatol 113:340-5. 1999
..These results support the hypothesis that the calcium-sensing receptor expressed in keratinocytes mediates at least part of the intracellular calcium response to extracellular calcium and calcium-induced differentiation...
- L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites
Department of Medicine, Endocrine Hypertension Division, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
J Biol Chem 277:33736-41. 2002
..The two-site model is further supported by the observation that these two classes of modulators exert a synergistic effect on CaRs with inactivating mutations that are responsive to both modulators...