aniline compounds


Top Publications

  1. ncbi Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Ann Neurol 55:306-19. 2004
  2. ncbi ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
    Christin Tse
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
    Cancer Res 68:3421-8. 2008
  3. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
  4. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
  5. pmc The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core
    William J Jagust
    Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA
    Alzheimers Dement 6:221-9. 2010
  6. ncbi Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
    L L Remsing Rix
    Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Leukemia 23:477-85. 2009
  7. ncbi In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells
    Miriam Puttini
    Department of Clinical Medicine, S Gerardo Hospital University of Milano Bicocca, Monza, Italy
    Cancer Res 66:11314-22. 2006
  8. ncbi Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib
    Jorge E Cortes
    M D Anderson Cancer Center, Houston, TX, USA
    Blood 118:4567-76. 2011
  9. pmc Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
    Clifford R Jack
    Clifford R Jack, Mayo Clinic, Diagnostic Radiology, 200 First Street SW, Rochester, MN 55905, USA
    Brain 132:1355-65. 2009
  10. ncbi Performance characteristics of amyloid PET with florbetapir F 18 in patients with alzheimer's disease and cognitively normal subjects
    Abhinay D Joshi
    Avid Radiopharmaceuticals, Inc, Philadelphia, PA 19104, USA
    J Nucl Med 53:378-84. 2012

Detail Information

Publications295 found, 100 shown here

  1. ncbi Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Ann Neurol 55:306-19. 2004
    ..This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects...
  2. ncbi ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
    Christin Tse
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
    Cancer Res 68:3421-8. 2008
    ..The oral efficacy of ABT-263 should provide dosing flexibility to maximize clinical utility both as a single agent and in combination regimens...
  3. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
    ..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden...
  4. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
  5. pmc The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core
    William J Jagust
    Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA
    Alzheimers Dement 6:221-9. 2010
    ..This is a progress report of the Alzheimer's Disease Neuroimaging Initiative (ADNI) positron emission tomography (PET) Core...
  6. ncbi Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
    L L Remsing Rix
    Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Leukemia 23:477-85. 2009
    ..Finally, bosutinib is the first kinase inhibitor shown to target CAMK2G, recently implicated in myeloid leukemia cell proliferation...
  7. ncbi In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells
    Miriam Puttini
    Department of Clinical Medicine, S Gerardo Hospital University of Milano Bicocca, Monza, Italy
    Cancer Res 66:11314-22. 2006
    ..Modeling considerations attribute the superior activity of SKI-606 to its ability to bind a conformation of Bcr-Abl different from imatinib...
  8. ncbi Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib
    Jorge E Cortes
    M D Anderson Cancer Center, Houston, TX, USA
    Blood 118:4567-76. 2011
    ..These data suggest bosutinib is effective and tolerable in patients with chronic phase imatinib-resistant or imatinib-intolerant CML. This trial was registered at as NCT00261846...
  9. pmc Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
    Clifford R Jack
    Clifford R Jack, Mayo Clinic, Diagnostic Radiology, 200 First Street SW, Rochester, MN 55905, USA
    Brain 132:1355-65. 2009
    ..This model implies a complimentary role for MRI and PIB imaging in Alzheimer's disease, with each reflecting one of the major pathologies, amyloid dysmetabolism and neurodegeneration...
  10. ncbi Performance characteristics of amyloid PET with florbetapir F 18 in patients with alzheimer's disease and cognitively normal subjects
    Abhinay D Joshi
    Avid Radiopharmaceuticals, Inc, Philadelphia, PA 19104, USA
    J Nucl Med 53:378-84. 2012
    ..In a separate set of subjects (AD, n = 10; YHCs, n = 10), test-retest reliability was evaluated by comparing intrasubject visual read ratings and SUVrs for 2 PET images acquired within 4 wk of each other...
  11. ncbi Bax and Bcl-xL exert their regulation on different sites of the ceramide channel
    Meenu N Perera
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Biochem J 445:81-91. 2012
    ..Molecular docking simulations of the lowest-energy binding poses of ceramides and Bcl-xL inhibitors to Bcl-xL were consistent with the results of our functional studies and propose potential binding modes...
  12. ncbi Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism
    Norma Marchesini
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29425, USA
    J Biol Chem 278:13775-83. 2003
    ..In conclusion, these results 1) show that nSMase2 is a structural gene for nSMase, 2) suggest that nSMase2 acts as a bona fide N-SMase in cells, and 3) implicate nSMase2 in the regulation of cell growth and cell signaling...
  13. ncbi Novel aspects of therapy with the dual Src and Abl kinase inhibitor bosutinib in chronic myeloid leukemia
    Gunhild Keller-V Amsberg
    Klinik für Hämatologie und Onkologie mit der Sektion Pneumologie, Onkologisches Zentrum, Universitäts Klinikum Hamburg Eppendorf, Hamburg, Germany
    Expert Rev Anticancer Ther 12:1121-7. 2012
    ..This may be causative for its favorable hematologic toxicity profile. In this review, the authors give an overview on the mechanism of action and currently available preclinical and clinical data for bosutinib in CML...
  14. ncbi Degradation of aniline by newly isolated, extremely aniline-tolerant Delftia sp. AN3
    Z Liu
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, P R China
    Appl Microbiol Biotechnol 58:679-82. 2002
    ..Based on the results obtained, a pathway for the degradation of aniline by Delftiasp. AN3 was proposed. The importance of the strain to the operation of municipal wastewater treatment plants is discussed...
  15. ncbi 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
    Juha O Rinne
    Turku PET Centre and Clinical Research Services Turku, University of Turku and Turku University Hospital, Turku, Finland
    Lancet Neurol 9:363-72. 2010
    ..We used (11)C-PiB PET to investigate whether bapineuzumab, a humanised anti-amyloid-beta monoclonal antibody, would reduce cortical fibrillar amyloid-beta load in patients with Alzheimer's disease...
  16. pmc SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells
    Adina Vultur
    Molecular Medicine, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Mol Cancer Ther 7:1185-94. 2008
    ..Our findings indicate that SKI-606 inhibits signaling pathways involved in controlling tumor cell motility and invasion, suggesting that SKI-606 is a promising therapeutic for breast cancer...
  17. ncbi Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent--a pilot study
    Kun Ju Lin
    Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan
    Nucl Med Biol 37:497-508. 2010
    ..This pilot study reports the safety, biodistribution, and radiation dosimetry of [(18)F]AV-45 in human subjects...
  18. ncbi Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging
    V B Gupta
    Centre of Excellence for Alzheimer s Disease Research and Care, School of Exercise Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
    Neurology 76:1091-8. 2011
    ..The major objective of this cross-sectional study was to investigate total plasma apoE as well as levels of the apoE4 form in a large, highly characterized cohort which included both healthy controls and participants with early-stage AD...
  19. pmc A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth
    Vita M Golubovskaya
    Department of Surgery, UF Shands Cancer Center, Department of Pathology and Laboratory Medicine, University of Florida, Gainesville, Florida 32610 0245, USA
    J Med Chem 51:7405-16. 2008
    ..Furthermore, 14 effectively caused breast tumor regression in vivo. Thus, targeting the Y397 site of FAK with 14 inhibitor can be effectively used in cancer therapy...
  20. ncbi Conducting polymers in electronic chemical sensors
    Jiri Janata
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
    Nat Mater 2:19-24. 2003
    ..Our aim here is to discuss the usability of conducting polymers in both types of electronic applications in light of these two parameters...
  21. ncbi SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models
    Jennifer M Golas
    Department of Oncology, Wyeth Research, Pearl River, New York 10965, USA
    Cancer Res 65:5358-64. 2005
    ..These results support development of SKI-606 as a therapeutic agent for treatment of colorectal cancer...
  22. ncbi SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling
    Addolorata Maria Luce Coluccia
    Department of Experimental Oncology, National Cancer Institute, Milan, Italy
    Cancer Res 66:2279-86. 2006
  23. ncbi Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
  24. ncbi Degradation of 3,4-dichloro- and 3,4-difluoroaniline by Pseudomonas fluorescens 26-K
    Vassili M Travkin
    G K Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino, Moscow Region, Russia
    J Environ Sci Health B 38:121-32. 2003
    ..08 micromol/min/mg of protein) was found in the cell-free extract of biomass grown on 3,4-DFA. 3-Fluoro-4-hydroxyaniline as intermediate was found in this cell-free extract...
  25. ncbi Biodegradation of 4-chloroaniline by bacteria enriched from soil
    Alisa S Vangnai
    Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    FEMS Microbiol Lett 268:209-16. 2007
    ..These results suggest that these isolates have a potential use for bioremediation of the site contaminated with 4-chloroaniline...
  26. pmc Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases
    M A Battistone
    Instituto de Biologia y Medicina Experimental, IBYME CONICET, Ciudad Autonoma de Buenos Aires, C1428ADN Buenos Aires, Argentina
    Mol Hum Reprod 19:570-80. 2013
  27. ncbi Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia
    Shi Liang
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 331:827-35. 2009
    ..These data demonstrate that the novel Src kinase inhibitors provide effective treatment against ischemic conditions within a clinically relevant therapeutic window and may constitute a viable therapy for acute stroke...
  28. ncbi SEA0400, a novel Na+/Ca2+ exchanger inhibitor, reduces calcium overload induced by ischemia and reperfusion in mouse ventricular myocytes
    J Wang
    Department of Physiology, Capital University of Medical Sciences, Beijing, China
    Physiol Res 56:17-23. 2007
    ..The results suggested that SEA0400 is a potent NCX inhibitor, which can protect mouse cardiac myocytes from Ca2+ overload during I/R injuries...
  29. pmc Pathway and evolutionary implications of diphenylamine biodegradation by Burkholderia sp. strain JS667
    Kwanghee A Shin
    School of Civil and Environmental Engineering, Georgia Institute of Technology, 311 Ferst Dr, Atlanta, GA 30332 0512, USA
    Appl Environ Microbiol 75:2694-704. 2009
    ..Both the sequence similarity and the gene organization suggest that the DPA degradation pathway evolved recently by the recruitment of two gene clusters that encode the DPA dioxygenase and aniline degradation pathway...
  30. ncbi Biodegradation potential of pure and mixed bacterial cultures for removal of 4-nitroaniline from textile dye wastewater
    Azeem Khalid
    Department of Environmental Sciences, PMAS Arid Agriculture University, Rawalpindi 46300, Pakistan
    Water Res 43:1110-6. 2009
    ..Our findings show that enrichment cultures from activated sludge can be effective for the removal of dyes and their toxic intermediates, and that treatment may best be accomplished using an anaerobic-aerobic process...
  31. ncbi Prostaglandin E2 activates channel-mediated calcium entry in human erythrocytes: an indication for a blood clot formation supporting process
    Lars Kaestner
    Institute for Molecular Cell Biology, Faculty of Medicine, Building 61, Saarland University, 66421 Homburg Saar, Germany
    Thromb Haemost 92:1269-72. 2004
    ..Therefore, we conclude that the PGE(2) responses of red blood cells described here reveal a direct and active participation of erythrocytes in blood clot formation...
  32. ncbi Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action
    Guillaume Lucas
    Universite McGill, Departement de Psychiatrie, Bâtiment de Recherche et de Formation, Bureau 207, 1033 Avenue des Pins Ouest, Montreal, QC, H3A 1A1 Canada
    Neuron 55:712-25. 2007
    ..These findings point out 5-HT(4) receptor agonists as a putative class of antidepressants with a rapid onset of action...
  33. ncbi Reduction by SEA0400 of myocardial ischemia-induced cytoplasmic and mitochondrial Ca2+ overload
    Iyuki Namekata
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Miyama 2 2 1 Funabashi, Chiba 274 8510, Japan
    Eur J Pharmacol 543:108-15. 2006
    ..SEA0400 significantly delayed these changes. These results suggest that SEA0400 maintains mitochondrial function and tissue ATP content during ischemia through the inhibition of cytoplasmic and mitochondrial Ca(2+) overload...
  34. pmc Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Federal Republic of Germany
    Biol Psychiatry 68:879-84. 2010
    ..Only few data have been published on in vivo longitudinal changes of amyloid load in Alzheimer's disease (AD) patients, with conflicting results. Therefore, little is known about the factors that influence these changes...
  35. ncbi Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy
    M Campone
    Department of Medical Oncology, Centre Rene Gauducheau, Nantes Saint Herblain, France
    Ann Oncol 23:610-7. 2012
    ..This phase II study evaluated single-agent bosutinib in pretreated patients with locally advanced or metastatic breast cancer...
  36. pmc Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy
    Ryuji Yamaguchi
    Program of Cell Death and Apoptosis, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e24102. 2011
  37. pmc Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells
    Nicola Antonio Martino
    Department of Animal Production, Faculty of Biotechnological Sciences, University of Bari, Valenzano, Bari, Italy
    PLoS ONE 6:e17714. 2011
    ..The involvement of CaSR on observed cell response was analyzed at both the mRNA and protein level...
  38. ncbi Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer's disease
    Victor L Villemagne
    Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia
    Eur J Nucl Med Mol Imaging 39:983-9. 2012
    ..The purpose of this analysis was to compare data on cortical Aβ deposition in subjects who had undergone both (11)C-PiB (PiB) and (18)F-florbetaben (FBB) PET imaging...
  39. ncbi Recent advances in polyaniline based biosensors
    Chetna Dhand
    Department of Science and Technology Centre on Biomolecular Electronics, Biomedical Instrumentation Section, Materials Physics and Engineering Division, National Physical Laboratory, Council of Scientific and Industrial Research, Dr KS Krishnan Marg, New Delhi 110012, India
    Biosens Bioelectron 26:2811-21. 2011
    ..Efforts have been made to discuss and explore various characteristics of PANI responsible for direct electron transfer leading towards fabrication of mediator-less biosensors...
  40. pmc Metabolism of 2-chloro-4-nitroaniline via novel aerobic degradation pathway by Rhodococcus sp. strain MB-P1
    Fazlurrahman Khan
    Institute of Microbial Technology, Council of Scientific and Industrial Research, Chandigarh, India
    PLoS ONE 8:e62178. 2013
    ..This is the first report showing 2-C-4-NA degradation and elucidation of corresponding metabolic pathway by an aerobic bacterium...
  41. ncbi ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
    Scott Ackler
    Global Pharmaceutical Research and Development, Abbott Laboratories, Building AP3 105, 100 Abbott Park Road, Abbott Park, IL 60064 6074, USA
    Mol Cancer Ther 7:3265-74. 2008
    ..These data suggest that combination of ABT-263 and rapamycin or its analogues represents a promising therapeutic strategy for the treatment of lymphoma...
  42. pmc Surface-enhanced Raman scattering on tunable plasmonic nanoparticle substrates
    J B Jackson
    Department of Physics and Astronomy, Laboratory of Nanophotonics, and Rice Quantum Institute, Rice University, Houston, TX 77005, USA
    Proc Natl Acad Sci U S A 101:17930-5. 2004
    ..SERS enhancements as large as 2.5 x 10(10) on Ag nanoshell films for the nonresonant molecule p-mercaptoaniline are measured...
  43. ncbi Use of florbetapir-PET for imaging beta-amyloid pathology
    Christopher M Clark
    Avid Radiopharmaceuticals, Philadelphia, Pennsylvania, USA
    JAMA 305:275-83. 2011
    ..The ability to identify and quantify brain β-amyloid could increase the accuracy of a clinical diagnosis of Alzheimer disease...
  44. ncbi Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines
    Stephen K Tahir
    Global Pharmaceutical Product Research Division, Abbott Laboratories, Abbott Park, Illinois 60064 6099, USA
    Mol Cancer Ther 9:545-57. 2010
    ..This study leverages global expression data to identify key gene expression patterns for sensitivity to ABT-263 in SCLC and leukemia/lymphoma and may provide guidance in the selection of patients in future clinical trials...
  45. ncbi Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
    Christopher C Rowe
    Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, Victoria, Australia
    Neurobiol Aging 31:1275-83. 2010
  46. ncbi A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats
    Steve McGaraughty
    Neuroscience Research, Abbott Laboratories, R4PM, AP9 1, 100 Abbott Park Rd, Abbott Park, IL 60064 6118, USA
    J Pharmacol Exp Ther 324:1204-11. 2008
    ..However, Na(v)1.8 sodium channels on central terminals seem to be key to the modulation of spontaneous firing in SNL rats...
  47. pmc Consequence of one-electron oxidation and one-electron reduction for aniline
    Ewa D Raczyńska
    Department of Chemistry, Warsaw University of Life Sciences SGGW, ul Nowoursynowska 159C, 02 776 Warszawa, Poland
    J Mol Model 17:3229-39. 2011
    ..The change of the tautomeric preferences for reduced aniline may partially explain the origin of the CH tautomers for reduced nucleobases (cytosine, adenine, and guanine)...
  48. pmc Imaging amyloid deposition in Lewy body diseases
    S N Gomperts
    Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 71:903-10. 2008
    ..In addition to widespread distribution of Lewy bodies, both diseases have variable burdens of neuritic plaques and neurofibrillary tangles characteristic of Alzheimer disease (AD)...
  49. ncbi Intercellular communication mediated by the extracellular calcium-sensing receptor
    A M Hofer
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massahusetts 02115, USA
    Nat Cell Biol 2:392-8. 2000
    ..The CaR may therefore mediate a universal form of intercellular communication that allows cells to be informed of the Ca2+-signalling status of their neighbours...
  50. pmc A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
    Michael F Jarvis
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
    Proc Natl Acad Sci U S A 104:8520-5. 2007
    ..These data demonstrate that acute and selective pharmacological blockade of Na(v)1.8 sodium channels in vivo produces significant antinociception in animal models of neuropathic and inflammatory pain...
  51. ncbi Chromosome-encoded gene cluster for the metabolic pathway that converts aniline to TCA-cycle intermediates in Delftia tsuruhatensis AD9
    Quanfeng Liang
    Department of Microbiology, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie, Beijing 100081, P R China
    Microbiology 151:3435-46. 2005
    ..The tad gene cluster showed significant similarity in nucleotide sequence and genetic organization to the plasmid-encoded aniline degradation gene cluster of Pseudomonas putida UCC22...
  52. ncbi The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo
    Scott Ackler
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Cancer Chemother Pharmacol 66:869-80. 2010
    ..This study was designed to test the ability of the Bcl-2 family inhibitor ABT-263 to potentiate commonly used chemotherapeutic agents and regimens in hematologic tumor models...
  53. pmc Genetic diversity among 3-chloroaniline- and aniline-degrading strains of the Comamonadaceae
    N Boon
    Laboratory of Microbial Ecology and Technology, Ghent University, B-9000 Ghent, Belgium
    Appl Environ Microbiol 67:1107-15. 2001
    ..1 and P. putida UCC22 were only about 83% identical to the other sequences. Northern hybridization revealed that the tdnQ gene is transcribed only in the presence of aniline and not when only 3-CA is present...
  54. ncbi Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias
    Victor L Villemagne
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
    J Nucl Med 52:1210-7. 2011
  55. ncbi High-rate biodegradation of 3- and 4-nitroaniline
    A Saupe
    Fraunhofer Management GmbH, Germany
    Chemosphere 39:2325-46. 1999
    ..Partial nitrification, also occurred. After gradual adaptation, the bacteria also degraded 3-NA and 4-NA simultaneously in this system. Additional batch tests showed, that 3-NA can serve as the sole source of carbon, nitrogen and energy...
  56. pmc Activity correlation imaging: visualizing function and structure of neuronal populations
    Stephan Junek
    Department of Neurophysiology and Cellular Biophysics, University of Gottingen, Gottingen, Germany
    Biophys J 96:3801-9. 2009
    ..This method, yielding both functional and structural information of neuronal populations, will open up unprecedented possibilities for the investigation of neuronal networks...
  57. ncbi Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK channels
    Sebastian Hepp
    Zentrum für Physiologie und Pathophysiologie, Abteilung Neuro und Sinnesphysiologie, Georg August Universitat Gottingen, Gottingen, Germany
    J Neurophysiol 94:1091-103. 2005
    ..Accordingly, ionic disregulation and the loss of membrane potential occur later or might even be prevented during short-term insults. Therefore well-directed oxidation of SH groups could mediate neuroprotection...
  58. pmc In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia
    M A Burack
    Department of Neurology and Pediatrics, 601 Elmwood Avenue, Box 673, University of Rochester Medical Center, Rochester, NY 14642, USA
    Neurology 74:77-84. 2010
    ..To investigate the specificity of in vivo amyloid imaging with [(11)C]-Pittsburgh Compound B (PIB) in Parkinson disease dementia (PDD)...
  59. pmc Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia
    Gil D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 64:388-401. 2008
  60. ncbi Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models
    S K Joshi
    Abbott Laboratories, Neuroscience Research, Abbott Park, Illinois, USA
    J Pain 10:306-15. 2009
    ..Using such a combination strategy to produce analgesia may potentially provide an improved therapeutic separation from unwanted in vivo side effects associated with blockade of either Nav1.8 or TRPV1 alone...
  61. ncbi Calcium imaging of individual erythrocytes: problems and approaches
    Lars Kaestner
    Institute for Molecular Cell Biology, Faculty of Medicine, Saarland University, 66421 Homburg Saar, Germany
    Cell Calcium 39:13-9. 2006
    ..Our results emphasize that in erythrocytes measurements of intracellular calcium are reliably possible with Fluo-4 and that other indicators, especially those requiring UV-excitation, appear less favourable...
  62. ncbi Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells
    Mika Yamauchi
    Dept of Endocrinology, Metabolism, and Hematological Oncology, Shimane Univ School of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
    Am J Physiol Endocrinol Metab 288:E608-16. 2005
    ..This suggests that the CaR may be involved in osteoblastic differentiation...
  63. ncbi Nerve-highlighting fluorescent contrast agents for image-guided surgery
    Summer L Gibbs-Strauss
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Mol Imaging 10:91-101. 2011
    ..These results lay the foundation for the development of ideal nerve-highlighting fluorophores for image-guided surgery...
  64. pmc APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    John C Morris
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Ann Neurol 67:122-31. 2010
    ..To examine interactions of apolipoprotein E (APOE) genotype with age and with in vivo measures of preclinical Alzheimer disease (AD) in cognitively normal aging...
  65. pmc Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
    ..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood...
  66. ncbi Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
    ..MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage...
  67. ncbi Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line
    T Yamaguchi
    Endocrine-Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Cell Physiol 280:C382-93. 2001
    ..5 microM), but not its less active stereoisomer NPS S-467 (0.5 microM), activate an outward K+ channel in MG-63 cells, strongly suggesting that the CaR in MG-63 cells is not only expressed but is functionally active...
  68. pmc Constitutive expression of catABC genes in the aniline-assimilating bacterium Rhodococcus species AN-22: production, purification, characterization and gene analysis of CatA, CatB and CatC
    Eitaro Matsumura
    Division of Life Science, Graduate School of Science and Technology, Kobe University, Rokko, Kobe 657 8501, Japan
    Biochem J 393:219-26. 2006
    ..Based on these data, we concluded that the bacterium constitutively transcribed the catABC genes and translated its mRNA into CatA, CatB and CatC...
  69. ncbi Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
    Jun Maeda
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    J Neurosci 27:10957-68. 2007
  70. ncbi An update on dual Src/Abl inhibitors
    Francesca Musumeci
    Dipartimento di Scienze Farmaceutiche, University of Genoa, Viale Benedetto XV 3, I 16132 Genova, Italy
    Future Med Chem 4:799-822. 2012
    ..This review is an update on the most important dual inhibitors already in clinical trials and includes information regarding compounds that have appeared in the literature in recent years...
  71. ncbi Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor
    John Liddle
    GlaxoSmithKline R and D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
    Bioorg Med Chem Lett 21:6188-94. 2011
    ..GSK143 is a potent and highly selective SYK inhibitor showing good efficacy in the rat Arthus model...
  72. pmc Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells
    Mario Bonomini
    Institute of Nephrology Department of Medicine, University G D Annunzio, Chieti Pescara, Italy
    PLoS ONE 7:e30682. 2012
    ..Although it has been postulated that calcimimetics may have a direct effect on CaSR in the blood vessels, further studies are needed to elucidate their vascular CaSR-dependent versus CaSR-independent effects...
  73. ncbi Enzymatically synthesized polyaniline layer for extension of linear detection region of amperometric glucose biosensor
    Asta Kausaite-Minkstimiene
    NanoTechnas Center of Nanotechnology and Material Science, Faculty of Chemistry, Vilnius University, Naugarduko 24, 03225 Vilnius, Lithuania
    Biosens Bioelectron 26:790-7. 2010
    ..An increase in the upper detection limit, optimal pH region for operation and stability of GOx based electrode modified by PANI was detected when comparing that of an unmodified GOx-electrode...
  74. ncbi Biodegradation pathways of chloroanilines by Acinetobacter baylyi strain GFJ2
    Parnuch Hongsawat
    International Postgraduate Program in Environmental Management, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand
    J Hazard Mater 186:1300-7. 2011
    ..baylyi strain GFJ2 in bioremediation and waste treatment, and the kinetic data provide the insights into the degradation mechanism, dynamics and possible limitations of the biodegradation which include substrate and product inhibitions...
  75. ncbi Superparamagnetic Fe3O4 nanoparticles as catalysts for the catalytic oxidation of phenolic and aniline compounds
    Shengxiao Zhang
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing, China
    J Hazard Mater 167:560-6. 2009
    ..and reusability, also showed excellent catalysis ability to eliminate some substituted phenolic and aniline compounds from solution...
  76. ncbi Biological transformation pathways of 2,4-dinitro anisole and N-methyl paranitro aniline in anaerobic fluidized-bed bioreactors
    William E Platten
    Civil and Environmental Engineering Department, University of Cincinnati, Cincinnati, OH 45221, USA
    Chemosphere 81:1131-6. 2010
    ..The AFBB technology was shown here to be an effective means of removing the new munitions, but produce secondary compounds that could potentially be just as harmful and require further study...
  77. ncbi Alcohol vapours sensor based on thin polyaniline salt film and quartz crystal microbalance
    Mohamad M Ayad
    Department of Chemistry, University of Tanta, Tanta, Egypt
    Talanta 78:1280-5. 2009
    ..The sensor shows a good reproducibility and reversibility. The diffusion and diffusion coefficient (D) of different alcohols vapour were determined. It was found that the sensor follows Fickian kinetics...
  78. ncbi Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles
    D H Boschelli
    Chemical Sciences and Oncology, Wyeth Ayerst Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 44:822-33. 2001
    ..Compound 25, which contains a 3-morpholinopropoxy group, had an IC(50) of 3.8 nM in the Src enzymatic assay and an IC(50) of 940 nM for the inhibition of Src-dependent cell proliferation...
  79. ncbi Persistence of chlorpyrifos, fenamiphos, chlorothalonil, and pendimethalin in soil and their effects on soil microbial characteristics
    B Kumar Singh
    Department of Biological Sciences, Imperial College at Silwood Park, Ascot, Berks SL5 7PY, United Kingdom
    Bull Environ Contam Toxicol 69:181-8. 2002
  80. ncbi Polyaniline synthesis and its biosensor application
    Zarini Muhammad Tahir
    Biosystems Engineering, Michigan State University, East Lansing, MI 48824, USA
    Biosens Bioelectron 20:1690-5. 2005
    ..Further modification could be implemented to evaluate the biosensor as a rapid diagnostic device to detect other infectious disease outbreaks in livestock population...
  81. ncbi Calcimimetic and calcilytic drugs: just for parathyroid cells?
    E F Nemeth
    NPS Pharmaceuticals, Inc, 30 College Street, Suite 301, Toronto, Ont, Canada
    Cell Calcium 35:283-9. 2004
  82. ncbi Degradation of dichloroaniline isomers by a newly isolated strain, Bacillus megaterium IMT21
    Xie Feng Yao
    Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects, Ministry of Agriculture, Nanjing 210095, China
    Microbiology 157:721-6. 2011
    ..These five DCA isomers were degraded via two different routes. 2,3-, 2,4- and 2,5-DCA were degraded via previously unknown dichloroaminophenol metabolites, whereas 3,4- and 3,5-DCA were degraded via dichloroacetanilide...
  83. ncbi SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
    Jennifer M Golas
    Departments of Oncology, Wyeth Research, Pearl River, New York 10965, USA
    Cancer Res 63:375-81. 2003
    ..Once daily oral administration of this compound at 100 mg/kg for 5 days causes complete regression of large K562 xenografts in nude mice...
  84. ncbi Acidity of anilines: calculations vs experiment
    Lauri Lipping
    Institute of Chemistry, University of Tartu, 14a Ravila St, 50411 Tartu, Estonia
    J Phys Chem A 115:10335-44. 2011
    ..The method proved to be rather accurate for showing pK(a) trends (R(2)=0.980 in DMSO). However, the predicted absolute pK(a) values were all somewhat lower (rmsd=2.49 kcal·mol(-1)) than the respective experimental values...
  85. ncbi A kinetic study on the degradation of p-nitroaniline by Fenton oxidation process
    Jian Hui Sun
    College of Chemistry and Environmental Sciences, Henan Normal University, Henan Key Laboratory for Environmental Pollution Control, Xinxiang, Henan 453007, PR China
    J Hazard Mater 148:172-7. 2007
    ..Based on the rate constants obtained at different temperatures, the empirical Arrhenius expression of PNA degradation was derived. The derived activation energy for PNA degradation by Fenton oxidation is 53.96 kJ mol(-1)...
  86. ncbi Simultaneous determination of five nitroaniline and dinitroaniline isomers in wastewaters by solid-phase extraction and high-performance liquid chromatography with ultraviolet detection
    Changlun Tong
    MOE Key Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China
    Chemosphere 81:430-5. 2010
    ..5 x 10(-9)M for 4-nitroaniline and 2,4-dinitroaniline. The proposed method was applied to determine the five isomers in real samples of acidic wastewater and printing and dyeing wastewater...
  87. pmc CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects
    Michael Ewers
    Department of Radiology, University of California, San Francisco, 94143, USA
    Cereb Cortex 22:1993-2004. 2012
  88. ncbi Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid
    Xiao Jia Yin
    School of Pharmacy, Nanjing Medical University, Nanjing 210029, China
    Molecules 15:4261-6. 2010
    ..The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC...
  89. pmc Optimization of automated radiosynthesis of [18F]AV-45: a new PET imaging agent for Alzheimer's disease
    Yajing Liu
    Key Laboratory of Radiopharmaceuticals, Beijing Normal University, Ministry of Education, Beijing, 100875, PR China
    Nucl Med Biol 37:917-25. 2010
    ..We report herein an optimal [(18)F]fluorination, de-protection condition and fully automated radiosynthesis of [(18)F]AV-45 ([(18)F]5) on a radiosynthesis module (BNU F-A2)...
  90. ncbi Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats
    Tobias Odenwald
    Department of Pediatrics, University of Heidelberg, Germany
    J Am Soc Nephrol 17:655-62. 2006
    ..1+/-4 versus 32.5+/-1.4 mmol/kg; P=0.01). The calcimimetic R-568 causes an initial BP increase in sham-operated and uremic rats, which in uremic rats is followed by a marked and sustained antihypertensive effect...
  91. ncbi Calcimimetic NPS R-568 induces hypotensive effect in spontaneously hypertensive rats
    Apolonia Rybczynska
    Laboratory of Pathophysiology, Medical University of Gdansk, ul Tuwuma 15, 80 210 Gdansk, Poland
    Am J Hypertens 18:364-71. 2005
    ..Parathyroidectomy decreases blood pressure in these rats and in patients. The present study determined whether phPTX induced by calcimimetics decreases mean arterial blood pressure (MAP) in hypertensive rats...
  92. ncbi Myeloperoxidase is a key regulator of oxidative stress mediated apoptosis in myeloid leukemic cells
    Tomonori Nakazato
    Division of Hematology, Department of Internal Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Cancer Res 13:5436-45. 2007
    ..This study aimed to further examine the mechanism of ROS-mediated apoptosis induced by EGCG and its relationship to the heme enzyme myeloperoxidase (MPO)...
  93. ncbi Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    Chester A Mathis
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Med Chem 46:2740-54. 2003
    ..The encouraging in vitro and in vivo properties of [(11)C]6-OH-BTA-1 support the choice of this derivative for further evaluation in human subject studies of brain Abeta deposition...
  94. ncbi Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study
    Nicolas Villain
    INSERM, U1077, Caen 14000, France
    Brain 135:2126-39. 2012
    ..Furthermore, this study identified the existence of Pittsburgh compound 'accumulators' and 'non-accumulators', notably within the Pittsburgh compound B-negative group, which may be a relevant concept for future studies...
  95. ncbi Retinoic acid induced suicidal erythrocyte death
    Olivier M Niemoeller
    Department of Physiology, University of Tuebingen, Tubingen, Germany
    Cell Physiol Biochem 21:193-202. 2008
    ..The eryptosis could participate in the accelerated clearance of parasitized erythrocytes from circulating blood following treatment with retinoids...
  96. ncbi The influence of suspended particles on the acute toxicity of 2-chloro-4-nitro-aniline, cadmium, and pentachlorophenol on the valve movement response of the zebra mussel (Dreissena polymorpha)
    J Borcherding
    Zoological Institute of the University of Cologne, Department of General Ecology and Limnology, , Germany
    Arch Environ Contam Toxicol 40:497-504. 2001
    ..The results are discussed with respect to the physiology of the organisms and the bioavailability of toxicants, as well as to the consequences these results may have under field conditions...
  97. ncbi Signal transduction in red blood cells of the lizards Ameiva ameiva and Tupinambis merianae (Squamata, Teiidae)
    F H Beraldo
    Departamento de Fisiologia, , , , Brazil
    Cell Calcium 29:439-45. 2001
    ..Finally, the purinergic agonist ATP triggers a rapid and transient increase of [Ca2+]c in the cells from both lizard species, mostly by mobilization of the cation from internal stores...
  98. ncbi The new role of calcimimetics as vasculotropic agents
    Ziyad Al-Aly
    Division of Nephrology, Saint Louis Veterans Affairs Medical Center, Saint Louis, Missouri, USA
    Kidney Int 75:9-12. 2009
    ..Koleganova et al. describe a novel role for calcimimetics as vasculotropes, which provides the impetus for further studies to characterize their effects on vascular biology...
  99. ncbi Acute cardiovascular effects of the calcimimetic R-568 and its enantiomer S-568 in rats
    Kumiko Nakagawa
    Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany
    Pediatr Nephrol 24:1385-9. 2009
    ..The calcimimetic R-568 exerts acute, CaSR-independent, hypotensive effects via vasodilation and negative chronotropy at concentrations exceeding those required for modulation of PTH secretion...
  100. ncbi Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes
    C L Tu
    Department of Medicine, University of California San Francisco and Endocrine Research Unit, Veterans Affairs Medical Center 94121, USA
    J Invest Dermatol 113:340-5. 1999
    ..These results support the hypothesis that the calcium-sensing receptor expressed in keratinocytes mediates at least part of the intracellular calcium response to extracellular calcium and calcium-induced differentiation...
  101. ncbi L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites
    Zaixiang Zhang
    Department of Medicine, Endocrine Hypertension Division, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Biol Chem 277:33736-41. 2002
    ..The two-site model is further supported by the observation that these two classes of modulators exert a synergistic effect on CaRs with inactivating mutations that are responsive to both modulators...

Research Grants66

  1. Xenobiotics, Lipid Peroxidation and Autoimmunity
    M Firoze Khan; Fiscal Year: 2006
    ..abstract_text> ..
    M Firoze Khan; Fiscal Year: 2010
    ..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
  3. Alzheimer's Diagnosis by Real-Time Motion Corrected FMRI
    Clifford Jack; Fiscal Year: 2004
    ..Aim number 4: to assess motion corrected fMRI as a diagnostic test for early Alzheimer's disease. ..
  4. Molecular and Functional Imaging of Age Related Cognitive Decline
    William Jagust; Fiscal Year: 2009
  5. Amyloid Imaging in Frontotemporal Dementia and Alzheimer's Disease
    William Jagust; Fiscal Year: 2009
    ..PIB could become a diagnostic tool that is useful in diagnosing AD and FTLD during life. This will be especially important as new treatments for both disorders are developed. ..
  6. Effects of Chemotherapy on Brain Function
    William J Jagust; Fiscal Year: 2010
    ..They are also relevant to the overall mission of the NIH because of the negative impact that cognitive dysfunction has on quality of life. ..
  7. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  8. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  9. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  10. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  11. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
  12. Coronary calcification in hemodialysis patients
    William Goodman; Fiscal Year: 2005
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  14. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
    Aleem Gangjee; Fiscal Year: 2004
    William Goodman; Fiscal Year: 2001
  17. Honors Undergraduate Research Training at SSU
    Harpal Singh; Fiscal Year: 2006
    ..A mandatory Bioethics course is proposed for MARC participants. The SSU MARC program is a concerted approach to enlarge the pool of minority biomedical scientists. ..
  18. EARDA Transition: Further Enhance Faculty and Student R*
    Harpal Singh; Fiscal Year: 2005
    ..The administration enthusiastically supports, and is committed to the continuation of research development capability of faculty and students when EARDA funding concludes. ..
  19. Ruthenium Catalyzed Bond Activation Reactions
    CHAE YI; Fiscal Year: 2006
    ..The proposed research will provide new catalytic methods for the synthesis of anticancer drugs and anti-inflammatory agents. [unreadable] [unreadable] [unreadable]..
    DEAN WONG; Fiscal Year: 2003
    ..Testing of these hypotheses will provide novel and fundamental answers to craving mechanisms. ..
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  22. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  24. PET Amyloid Plaque Imaging in Late Life Depression
    Yvette Sheline; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  25. New PET radioligand for the serotonin transporter
    Yiyun Huang; Fiscal Year: 2007
    ..Introduction of [18F]AFM would constitute the first PET tracer for the SERT that can be prepared in a central facility and distributed to various sites for clinical imaging purposes. ..
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  30. Anti-oxidant therapy in Alzheimer's disease
    Brian J Bacskai; Fiscal Year: 2010
    ..abstract_text> ..
    DEAN WONG; Fiscal Year: 2003
    ..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
    William Klunk; Fiscal Year: 2005
  33. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  34. Dedicated High Performance Human Brain/Preclinical PET
    DEAN WONG; Fiscal Year: 2004
    ..abstract_text> ..
    William Klunk; Fiscal Year: 2005
  36. Treatment Outcome of Vascular Depression
    Yvette Sheline; Fiscal Year: 2005
    ..The proposed trial will provide information of value to the practitioner and also provide data to build a more comprehensive model of the prognostic impact of frontal-subcortical brain changes on the outcome of late-life depression. ..
    ANNE FAGAN NIVEN; Fiscal Year: 2005
    ..Support for the hypothesis would establish a role for age-dependent defects in A-beta clearance from the brain in the pathogenesis of AD and, importantly, provide a novel therapeutic target for treatment of the disease. ..
    DEAN WONG; Fiscal Year: 2004
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  39. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  41. Mechanisms of amyloid-beta clearance.
    Brian Bacskai; Fiscal Year: 2006
    ..The results will strongly impact the development of treatments aimed at removing senile plaques and the associated neurological damage in Alzheimer's disease. ..
  42. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2006
    ..abstract_text> ..
  43. Vascular Depression: Longitudinal Followup
    Yvette I Sheline; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  44. Non-invasive optical imaging of neuropathology in vivo
    Brian J Bacskai; Fiscal Year: 2010
    ..The combined efforts from this project will lead to a new arsenal of molecular imaging tools to exploit the newly emerging technology of NIR spectroscopy. ..
  45. Center For Aging
    John Morris; Fiscal Year: 2006
    ..Dr. Morris is firmly committed to accomplishing these aims and, with this award and with outstanding institutional support, to establishing a preeminent Center for Aging at Washington University. ..
  46. Amyloid Imaging Agents for Position Emission Tomography
    Chester A Mathis; Fiscal Year: 2010
  47. Sequence Effects of Arylamine-DNA Adducts: Repair and Replication
    BONGSUP CHO; Fiscal Year: 2008
    ..Such knowledge will also be of help in the development of sensible prevention and risk assessment strategies. ..
  48. Regulation of Bile Ductular Proliferation
    JONATHAN DRANOFF; Fiscal Year: 2009
    ..We anticipate that the results of these proposed experiments will lead to novel pharmacologic approaches for the regulation of bile ductular proliferation in biliary cirrhosis. ..
  49. Low-Level Prenatal Lead Exposure and Retinal Toxicity
    Donald Fox; Fiscal Year: 2009
    Jan Mead; Fiscal Year: 2009
    ..This will be accomplished by immunizing mice with a DNA construct of these antigens, assessing their ability to elicit immune responses, and challenging mice with C. parvum to determine the degree of protection achieved. ..
  51. Pathways Linking Late-Life Depression to MCI & Dementia
    Meryl Butters; Fiscal Year: 2009
  52. Auditory thalamocortical integration, in vitro
    Heather Rose; Fiscal Year: 2003
    ..By increasing the understanding of cortical mechanisms in processing, auditory stimuli researchers will be able to advance treatments for the hearing impaired. ..
  53. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  54. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  55. The effect of nonoxynol-9 on human endometrium
    John Jain; Fiscal Year: 2005
    ..The results of this study will provide important preliminary information on the role of microbicides on endometrial toxicity and may help guide future research priorities. ..
  56. Genetic Risks for Medication-Related Hemorrhagic Stroke
    Steven Greenberg; Fiscal Year: 2007
    ..This proposal is thus likely to form the foundation of a powerful, open-ended search for a panel of genetic tests to determine an individual's risk for Warfarin-related ICH. ..
    Michelle Butler; Fiscal Year: 2005
    ..The SAR development and in vitro and in vivo characterization studies are the subject of this Phase II application. ..
  58. Phase I/II Study of MS-275 and 5-Azacytidine in Patients with Advanced Non-Small
    CHARLES RUDIN; Fiscal Year: 2008
    ..If successful, this approach could alter the poor prognosis of individuals with this disease. [unreadable] [unreadable] [unreadable]..
  59. Ca2+ Waves and Arrhythmias
    PENELOPE BOYDEN; Fiscal Year: 2008
    ..abstract_text> ..
  60. Gender differences in the interactions between endocannabinoids and stress
    Cecilia Hillard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
    HANK KUNG; Fiscal Year: 2004
    ..The novel imaging agents may lead to simple and useful routine diagnostic procedures for various mental health diseases involving SERT in the brain. ..
    ROBERT BRUEGGEMEIER; Fiscal Year: 2006
    ..3) To measure cellular levels of aromatase expression and cyclooxygenases expression in human breast cancer specimens. ..
  63. Antipsychotic Discontinuation in Alzheimer s Disease
    Davangere Devanand; Fiscal Year: 2008
    ..The results will be of considerable value to the practicing clinician and have substantial implications for the regulatory oversight of elder care. ..
  64. Transgene Induced HIV-Associated Nephropathy
    Vincent Gattone; Fiscal Year: 2004
    ..By studying this HIV-transgenic rat, we should be able to identify additional factors that contribute to the HIV-induced phenotype in GECs and provide new information that will lead to a rational treatment for HIVAN. ..
  65. High Pressure Freezing and Processing Unit
    Vincent Gattone; Fiscal Year: 2005
    ..The research and physical environment, EM Center personnel and IU School of Medicine institutional support make the IU EM Center an excellent place for the appropriate use of the Leica HPF and Processor System. ..
  66. Pathogenesis of wpk-induced Renal and Cerebral Disease
    Vincent Gattone; Fiscal Year: 2008
    ..abstract_text> ..