4 aminopyridine

Summary

Summary: One of the POTASSIUM CHANNEL BLOCKERS, with secondary effect on calcium currents, which is used mainly as a research tool and to characterize channel subtypes.

Top Publications

  1. ncbi Multi-state, 4-aminopyridine-sensitive ion channels in human spermatozoa
    Y Gu
    MRC Clinical Sciences Centre, Division of Medicine, Hammersmith Campus, Imperial College School of Medicine, W12 0NN, London, UK
    Dev Biol 274:308-17. 2004
  2. ncbi Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro
    Massimo Avoli
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Prog Neurobiol 68:167-207. 2002
  3. ncbi Antiepileptic effect of carbenoxolone on seizures induced by 4-aminopyridine: a study in the rat hippocampus and entorhinal cortex
    Laura Medina-Ceja
    Departamento de Biologia Celular y Molecular, Centro Universitario de Ciencias Biologicas y Agropecuarias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
    Brain Res 1187:74-81. 2008
  4. ncbi Fatigue in progressive multiple sclerosis: results of a randomized, double-blind, placebo-controlled, crossover trial of oral 4-aminopyridine
    P M Rossini
    AFaR-Ospedale San Giovanni Calibita Fatebenefratelli, Rome, Italy
    Mult Scler 7:354-8. 2001
  5. ncbi Characterization of potassium channels involved in volume regulation of human spermatozoa
    J P Barfield
    Institute of Reproductive Medicine, University of Munster, Munster, Germany
    Mol Hum Reprod 11:891-7. 2005
  6. ncbi Generalization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat
    Péter Baracskay
    Institute of Biology, Faculty of Natural Sciences, Eotvos Lorand University, H 1117 Budapest, Hungary
    Brain Res 1228:217-28. 2008
  7. ncbi Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 25:2192-203. 2005
  8. ncbi A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels
    K McCormack
    Max Planck Institut fur experimentelle Medizin, Gottingen, Federal Republic of Germany
    Neuron 12:301-15. 1994
  9. ncbi Combination of variable frequency train stimulation and K+ channel blockade to augment skeletal muscle force
    Erik van Lunteren
    Department of Medicine Pulmonary, Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Neural Syst Rehabil Eng 12:288-94. 2004
  10. ncbi Wheel-running exercise alters rat diaphragm action potentials and their regulation by K+ channels
    Erik van Lunteren
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Appl Physiol (1985) 95:602-10. 2003

Detail Information

Publications229 found, 100 shown here

  1. ncbi Multi-state, 4-aminopyridine-sensitive ion channels in human spermatozoa
    Y Gu
    MRC Clinical Sciences Centre, Division of Medicine, Hammersmith Campus, Imperial College School of Medicine, W12 0NN, London, UK
    Dev Biol 274:308-17. 2004
    ..Combined application of patch clamp and pharmacological investigation of mature sperm cells and will permit rapid advances in our understanding the role of ion channels in sperm function...
  2. ncbi Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro
    Massimo Avoli
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Prog Neurobiol 68:167-207. 2002
    ....
  3. ncbi Antiepileptic effect of carbenoxolone on seizures induced by 4-aminopyridine: a study in the rat hippocampus and entorhinal cortex
    Laura Medina-Ceja
    Departamento de Biologia Celular y Molecular, Centro Universitario de Ciencias Biologicas y Agropecuarias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
    Brain Res 1187:74-81. 2008
    ..We conclude that Gap junctions participate in the generation and propagation of epileptiform activity induced by 4-AP in these regions, as well as blocking motor alterations...
  4. ncbi Fatigue in progressive multiple sclerosis: results of a randomized, double-blind, placebo-controlled, crossover trial of oral 4-aminopyridine
    P M Rossini
    AFaR-Ospedale San Giovanni Calibita Fatebenefratelli, Rome, Italy
    Mult Scler 7:354-8. 2001
    ..05). Synchronization of motor evoked potentials improved during 4-AP with respect to placebo (P=0.019) and this correlated positively with fatigue reduction (P=0.010). No relevant side effects were observed...
  5. ncbi Characterization of potassium channels involved in volume regulation of human spermatozoa
    J P Barfield
    Institute of Reproductive Medicine, University of Munster, Munster, Germany
    Mol Hum Reprod 11:891-7. 2005
    ..Although Kv1.4, Kv1.7, TASK2 and TASK3 channels may have important roles in human spermatozoa, Kv1.5 and minK appear to be the most likely candidates for human sperm RVD, serving as targets for non-hormonal contraception...
  6. ncbi Generalization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat
    Péter Baracskay
    Institute of Biology, Faculty of Natural Sciences, Eotvos Lorand University, H 1117 Budapest, Hungary
    Brain Res 1228:217-28. 2008
    ..The EEG analysis revealed the generalization of the epileptic seizures. We found that the formation of "dark" neurons in the hippocampus and the pontine reticular formation paralleled the generalization of the seizures...
  7. ncbi Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 25:2192-203. 2005
    ..Therefore, because astrocytes discriminate and integrate synaptic information, we propose that they can be considered as cellular elements involved in the information processing by the nervous system...
  8. ncbi A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels
    K McCormack
    Max Planck Institut fur experimentelle Medizin, Gottingen, Federal Republic of Germany
    Neuron 12:301-15. 1994
    ..The transition between the two quaternary states moves about 10% of the total gating charge, and it is selectively blocked by 4-aminopyridine...
  9. ncbi Combination of variable frequency train stimulation and K+ channel blockade to augment skeletal muscle force
    Erik van Lunteren
    Department of Medicine Pulmonary, Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Neural Syst Rehabil Eng 12:288-94. 2004
    ..The utility of the combined intervention for functional electrical stimulation may be greatest for mechanical tasks requiring high force levels early during the contraction...
  10. ncbi Wheel-running exercise alters rat diaphragm action potentials and their regulation by K+ channels
    Erik van Lunteren
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Appl Physiol (1985) 95:602-10. 2003
    ..These data indicate that voluntary running slows diaphragm action potential repolarization, most likely by modulating K+ channel number or function...
  11. pmc K+ channel block-induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation
    B Rouzaire-Dubois
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS, 91198 Gif sur Yvette Cedex, France
    J Physiol 510:93-102. 1998
    ..This could take into account the role in mitogenesis of K+ channels and of other ionic pathways involved in cell volume regulation...
  12. ncbi Electrophysiologic and inotropic effects of K+-channel blockade in aged diaphragm
    E van Lunteren
    Departments of Medicine Pulmonary and Neurosciences, Cleveland Veterans Administration Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
    Am J Respir Crit Care Med 158:820-6. 1998
    ..Although the inotropic effect of DAP was greater for young-adult than for old diaphragm muscle, the difference was sufficiently modest to show that DAP has substantial inotropic effects in old muscle...
  13. ncbi Effects of tetraethylammonium and 4-aminopyridine on the plateau potential of circular myometrium from the pregnant rat
    D W Wilde
    Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912
    Biol Reprod 38:836-45. 1988
    ..The plateau potential may result from an outwardly rectifying TEA-sensitive current combined with a slow inward current, the plateau magnitude being determined by the relative intensity of each current...
  14. pmc A model for 4-aminopyridine action on K channels: similarities to tetraethylammonium ion action
    C M Armstrong
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biophys J 81:895-904. 2001
    ..The model is qualitatively the same as the one used for many years to explain the action of quaternary ammonium ions...
  15. ncbi Effects of voltage-gated ion channel modulators on rat prostatic cancer cell proliferation: comparison of strongly and weakly metastatic cell lines
    S P Fraser
    Neurobiology Group, Department of Biology, Imperial College of Science, Technology and Medicine, London, UK
    Prostate 44:61-76. 2000
    ..In the present study, the possible contribution of voltage-gated ion channel activity to the proliferation of these cell lines was investigated, in a comparative approach...
  16. ncbi In vivo treatment with the K+ channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampus
    Kiyokazu Ogita
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neuropharmacology 48:810-21. 2005
    ..Taken together, in vivo activation of NMDA receptors is capable of protecting against kainate-induced neuronal damage through blockade of DNA fragmentation induced by deoxyribonuclease II in the murine hippocampus...
  17. ncbi Influence of ion channels on the proliferation of human chondrocytes
    David Wohlrab
    Department of Orthopaedics, Martin Luther University, Halle Wittenberg, Germany
    Biorheology 39:55-61. 2002
    ..To gain knowledge of the regulation of chondrocyte proliferation via ion channel modulators could serve the research of new osteoarthritis treatment concepts...
  18. ncbi Improvement of dy/dy dystrophic diaphragm by 3,4-diaminopyridine
    Erik van Lunteren
    Department of Medicine, Pulmonary Division, Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, Ohio 44106, USA
    Muscle Nerve 26:71-8. 2002
    ..It is possible that DAP may be useful for the clinical management of a variety of disorders causing muscle weakness...
  19. ncbi Inotropic effects of the K+ channel blocker 3,4-diaminopyridine: differential responses of rat soleus and extensor digitorum longus
    Erik van Lunteren
    Cleveland Department of Veterans Affairs Medical Center, Cleveland OH, USA
    IEEE Trans Neural Syst Rehabil Eng 14:419-26. 2006
    ..Thus, the K+ channel blocker DAP improves contractile performance of limb muscles, but the profile of improvement is distinct between the soleus and EDL muscles...
  20. ncbi Long-lasting in vivo inotropic effects of the K(+) channel blocker 3,4-diaminopyridine during fatigue-inducing stimulation
    Erik van Lunteren
    Department of Pulmonary Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Muscle Nerve 38:1616-22. 2008
    ..These data provide support for a potential role for aminopyridines as inotropic agents in applications such as functional electrical stimulation, in which low to medium stimulation frequencies are typically utilized...
  21. pmc Resolving the gating charge movement associated with late transitions in K channel activation
    A Loboda
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA
    Biophys J 81:905-16. 2001
    ..The effect of 4AP is well modeled as a selective block of the final gating transition, which opens the channel. The final transition contributes approximately 5% of the total gating charge...
  22. ncbi Randomized trial of 4-aminopyridine in patients with chronic incomplete spinal cord injury
    M A van der Bruggen
    Department of Rehabilitation Medicine, University Hospital Vrije Universiteit Amsterdam, The Netherlands
    J Neurol 248:665-71. 2001
    ..To test the efficacy of 4-aminopyridine (4-AP) on functional status, walking speed and vibration perception in patients with chronic, incomplete spinal cord injury...
  23. ncbi 4-aminopyridine influences heart rate variability in long-standing spinal cord injury
    Jack L Segal
    Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
    Am J Ther 9:29-33. 2002
    ..4-Aminopyridine appears to influence ANS function and LF HRV in humans with long-standing SCI...
  24. ncbi The effects of 4-aminopyridine on motor evoked potentials in multiple sclerosis
    K Fujihara
    Department of Neurology, Kyushu Rosai Hospital, Kitakyushu, Japan
    J Neurol Sci 159:102-6. 1998
    ....
  25. ncbi Neuroscience. Animal studies raise hopes for spinal cord repair
    Ingrid Wickelgren
    Science 297:178-81. 2002
  26. ncbi GDNF acutely modulates excitability and A-type K(+) channels in midbrain dopaminergic neurons
    F Yang
    Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China 200031
    Nat Neurosci 4:1071-8. 2001
    ..These results demonstrate an acute regulation of GDNF on ion channels and its underlying signaling mechanism, and reveal an unexpected role of GDNF in normal midbrain dopaminergic neurons...
  27. ncbi Regulation of backpropagating action potentials in mitral cell lateral dendrites by A-type potassium currents
    J M Christie
    Vollum Institute, Oregon Health and Science University, Portland 97201, USA
    J Neurophysiol 89:2466-72. 2003
    ..Our results suggest that I(A) may regulate inhibition in the olfactory bulb by controlling action potential amplitudes in lateral dendrites...
  28. ncbi Potassium currents during the action potential of hippocampal CA3 neurons
    Jörg Mitterdorfer
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 22:10106-15. 2002
    ....
  29. pmc Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine
    J M Ridley
    Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Physiol 549:667-72. 2003
    ..We conclude that by blocking the alpha-subunit of the IKr channel, millimolar concentrations of 4-AP can modulate ventricular repolarisation independently of any action on ITO,1...
  30. ncbi Modulation of Ca(2+) signaling by K(+) channels in a hypothalamic neuronal cell line (GT1-1)
    J L Costantin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-1769, USA
    J Neurophysiol 85:295-304. 2001
    ..K(+) current modulation of electrical activity and Ca(2+) signaling may be important in the generation of the patterns of cellular activity responsible for the pulsatile release of GnRH...
  31. ncbi Developmental changes in the functional characteristics and expression of voltage-gated K+ channel currents in rat aortic myocytes
    Andriy E Belevych
    Centre for Cardiovascular Biology and Medicine, King s College London, St Thomas s Campus, SE1 7EH, UK
    Cardiovasc Res 54:152-61. 2002
    ..We therefore investigated changes in the functional characteristics and expression of Kv channels in rat aortic myocytes (RAMs) during early postnatal development...
  32. ncbi Voltage-dependent K+ currents in rat cardiac dorsal root ganglion neurons
    R Rola
    The Medical University of Warsaw, The Faculty of Medicine, Department of Experimental and Clinical Physiology, Krakowskie Przedmiescie 26 28, 00 927, Warsaw, Poland
    Neuroscience 119:181-91. 2003
    ..At depolarised membrane potentials the I(Af) K(+) current, the reactivation of which is very slow, does not oppose the firing rate of cardiac DRG neurons...
  33. ncbi In vivo gene transfer of Kv1.5 normalizes action potential duration and shortens QT interval in mice with long QT phenotype
    Michael Brunner
    Bioelectricity Laboratory, Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 285:H194-203. 2003
    ..Each of these changes is consistent with a physiologically significant primary effect of adenoviral expression of Kv1.5 on ventricular repolarization of Kv1DN mice...
  34. ncbi Effects of static magnetic fields on the voltage-gated potassium channel currents in trigeminal root ganglion neurons
    Jie Fei Shen
    Department of Prosthodontics, West China College of Stomatology, Sichuan University, No 14, Section 3, People s South Road, Chengdu, Sichuan 610041, China
    Neurosci Lett 415:164-8. 2007
    ..The mechanism underlying the different effects of SMF on the I(K,A) and I(K,V) inactivation was also discussed...
  35. ncbi Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells
    Eun A Ko
    Div of Pulmonary and Critical Care Medicine, Dept of Medicine, Univ of California, San Diego, 9500 Gilman Dr, MC 0725, La Jolla, CA 92093 0725, USA
    Am J Physiol Cell Physiol 293:C928-37. 2007
    ..4 +/- 2.7, 79.8 +/- 2.8, 46.0 +/- 2.2, and 23.6 +/- 0.6 pS, respectively. These studies provide detailed electrophysiological and pharmacological profiles of the native K(V) currents in mouse PASMCs...
  36. ncbi Ultrarapid delayed rectifier K(+) current in H9c2 rat ventricular cell line: biophysical property and molecular identity
    Hong Shi
    Research Center, Montreal Heart Institute, Montreal, Canada
    Cell Physiol Biochem 12:215-26. 2002
    ..We conclude that the H9c2 cells at the myoblast stage express mainly I(Kur) and Kv3.1b may be a molecular component of the H9c2 I(Kur), and H9c2 cells provide a suitable system for studying I(Kur)...
  37. ncbi The functional difference between transient and sustained K+ currents on the action potentials in tetrodotoxin-resistant adult rat trigeminal ganglion neurons
    Shinki Yoshida
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
    Brain Res 1152:64-74. 2007
    ..These results suggested that I(A) and I(K) had independent effects regulating the intrinsic firing properties of the action potential number and timing, respectively, in adult rat TTX-R TG neurons...
  38. ncbi Presynaptic factors in the regulation of DSI expression in hippocampus
    Namita Varma
    University of Maryland School of Medicine, Department of Physiology, 655 W Baltimore St, 21201, USA
    Neuropharmacology 43:550-62. 2002
    ..Significant DSI of mIPSCs remained in omega-conotoxin, hence we infer that block of N-channels does not fully explain hippocampal DSI expression...
  39. pmc Tetraethylammonium (TEA) increases the inactivation time constant of the transient K+ current in suprachiasmatic nucleus neurons
    Ludovic Alvado
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Sciences University, Portland, OR 97239 3098, USA
    Brain Res 1221:24-9. 2008
    ..We conclude that TEA modulates, in a concentration dependent manner, tau(inact) but not I(A) amplitude in hamster SCN neurons...
  40. ncbi Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells
    S S McDaniel
    Department of Medicine, University of California School of Medicine, San Diego, California 92103, USA
    J Appl Physiol 91:2322-33. 2001
    ..The membrane depolarization-mediated increase in [Ca2+]cyt in MASMC and mesenteric vasoconstriction may inhibit transportation of absorbed nutrients via mesenteric circulation and limit weight gain...
  41. pmc Electrophysiological properties and gap junction coupling of striatal astrocytes
    Louise Adermark
    Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892, USA
    Neurochem Int 52:1365-72. 2008
    ..Our findings indicate that the prevalent gap junction coupling is vital for astrocyte function in the striatum, and that whole-cell recordings will be distorted by currents activated in neighboring cells...
  42. ncbi Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release
    H Hu
    Institute of Physiology, University of Oslo, Blindern, N 0317 Oslo, Norway
    J Neurosci 21:9585-97. 2001
    ..These results indicate that the functional role of BK channels depends on their subcellular localization...
  43. ncbi Differential expression of intrinsic membrane currents in defined cell types of the anterolateral bed nucleus of the stria terminalis
    Sayamwong E Hammack
    Department of Psychiatry and Behavioral Science, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA
    J Neurophysiol 98:638-56. 2007
    ..The functional relevance of each cell type is discussed in relation to prior anatomical studies, as well as how these currents may interact to modulate neuronal activity within the BNST(ALG)...
  44. ncbi Streptozotocin-diabetes alters action potentials in rat diaphragm
    Erik van Lunteren
    Department of Medicine Pulmonary, Pulmonary Section 111J W, Cleveland V A Medical Center, Case Western Reserve University, 10701 East Boulevard, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 135:9-16. 2003
    ..These data indicate that diabetes shortens diaphragm action potentials, which appears to be due to altered K(+) channels...
  45. ncbi Ionic currents determining the membrane characteristics of type I spiral ganglion neurons of the guinea pig
    Z S Szabó
    University of Debrecen, Medical and Health Science Centre, Medical School, Department of Otolaryngology and Head and Neck Surgery, PO Box 26, Debrecen, H 4012, Hungary
    Eur J Neurosci 16:1887-95. 2002
    ..However, inhibition of the highly 4-AP- or DTX-I-sensitive component did not alter the rapidly inactivating nature of the firing pattern of the cells...
  46. ncbi Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons
    Angel Nunez
    Departamento de Morfologia, Facultad de Medicina, Universidad, Autonoma de Madrid, 28029, Spain
    J Neurophysiol 89:3008-17. 2003
    ..In turn, these changes probably contribute to functional reorganization processes such as expansion of neuronal receptive fields...
  47. pmc Lamina-specific membrane and discharge properties of rat spinal dorsal horn neurones in vitro
    Ruth Ruscheweyh
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Physiol 541:231-44. 2002
    ..Most of the neurones showing an initial burst were found in lamina II. These differences in membrane and discharge properties probably contribute to lamina-specific processing of sensory, including nociceptive, information...
  48. ncbi Two distinct types of transient outward currents in area postrema neurons in rat brain slices
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 942:31-45. 2002
    ..We discuss the role of I(to) as the ionic current underlying neuronal excitability...
  49. ncbi Chronic carbon monoxide enhanced IbTx-sensitive currents in rat resistance pulmonary artery smooth muscle cells
    Eric Dubuis
    Laboratoire de Physiopathologie de la paroi arterielle, Faculte de Medecine, 37032 Tours, France
    Am J Physiol Lung Cell Mol Physiol 283:L120-9. 2002
    ..The present study provides initial evidence of an increase of Ca2+-activated K+ current in smooth muscle cells from PA of rats exposed to chronic CO...
  50. ncbi Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action?
    Michael Madeja
    Institute for Physiology, University Munster, Robert Koch Str 27a, 48149 Munster, Germany
    Neuropharmacology 45:661-71. 2003
    ..This suggests that a reduction of potassium currents may contribute to the antiepileptic effect(s) of levetiracetam...
  51. ncbi Modulation of the voltage-dependent K+ current by intracellular Mg2+ in rat aortic smooth muscle cells
    Paolo Tammaro
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, U K
    Cardiovasc Res 65:387-96. 2005
    ..However, potential targets and mechanisms of action of Mg2+i in the cardiovascular system remain poorly understood. We therefore investigated the effect of Mg2+i on the voltage-gated K+ (KV) channels in rat aortic myocytes (RAMs)...
  52. ncbi A-type voltage-gated K+ currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons
    Amaresh Vydyanathan
    Department of Anesthesiology, H187, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Neurophysiol 93:3401-9. 2005
    ..The difference in the density of A-type Kv currents contributes to the distinct electrophysiological properties of IB4-positive and -negative DRG neurons...
  53. ncbi Characterization of the ion channel currents in single myocytes of the guinea pig prostate
    Richard J Lang
    Department of Physiology, Monash University, Clayton 3800, Victoria, Australia
    J Urol 172:1179-87. 2004
    ..We characterized membrane ionic currents underlying the action potential in single myocytes freshly isolated from the stroma of the guinea pig prostate...
  54. ncbi Orexins cause depolarization via nonselective cationic and K+ channels in isolated locus coeruleus neurons
    Yoshinaka Murai
    Department of Oral Functional Science Physiology, Graduate School of Dental Medicine, Hokkaido University, Kita 13 Nishi 7, Kita ku, Sapporo 060 8586, Japan
    Neurosci Res 51:55-65. 2005
    ..These results suggest that ORX-A/B increase the firing frequency of LC neurons through the depolarization probably produced by both augmentation of the nonselective cationic conductance and inhibition of the sustained K+ conductance...
  55. ncbi Two opposing roles of 4-AP-sensitive K+ current in initiation and invasion of spikes in rat mesencephalic trigeminal neurons
    Mitsuru Saito
    Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Neurophysiol 96:1887-901. 2006
    ..Consistent with these findings, strong immunoreactivities for Kv1.1 and Kv1.6, among 4-AP-sensitive and low-voltage-activated Kv1 family examined, were detected in the soma but not in the stem axon of MTN neurons...
  56. ncbi A-type K+ current of dopamine and GABA neurons in the ventral tegmental area
    Susumu Koyama
    Department of Physiology and Biophysics, University of Illinois at Chicago, 60612 7342, USA
    J Neurophysiol 96:544-54. 2006
    ..We suggest that I(A) contributes more to the regulation of AP generation in DA VTA neurons than in GABA VTA neurons...
  57. ncbi Sodium-activated potassium conductance participates in the depolarizing afterpotential following a single action potential in rat hippocampal CA1 pyramidal cells
    Xinhuai Liu
    Department of Physiology, University of Western Ontario, London, ON, Canada
    Brain Res 1023:185-92. 2004
    ..It is suggested that Li(+) increased DAP by blocking an Na(+)-activated K(+) current. In summary, multiple K(+) conductances are normally active during the DAP following a single action potential...
  58. ncbi Adenosine stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodies
    Fenglian Xu
    Dept of Pharmacology and Center for Neurosciences, Univ of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Am J Physiol Cell Physiol 290:C1592-8. 2006
    ..This leads to depolarization and activation of Ca2+ entry via VGCC. This excitatory action of adenosine on type I cells may contribute to the chemosensitivity of the carotid body during hypoxia...
  59. ncbi Complex expression and localization of inactivating Kv channels in cultured hippocampal astrocytes
    Lane K Bekar
    Department of Physiology, University of Saskatchewan, Rm B39 Health Sciences Bldg, Saskatoon, SK, S7N 5E5, Canada
    J Neurophysiol 93:1699-709. 2005
    ..However, this study suggests that they enable astrocytes to respond rapidly with membrane voltage oscillations to high-frequency incoming signals, possibly synchronizing astrocyte function to neuronal activity...
  60. ncbi State-dependent enhancement of subthreshold A-type potassium current by 4-aminopyridine in tuberomammillary nucleus neurons
    Alexander C Jackson
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 27:10785-96. 2007
    ..Thus, the state dependence of 4-AP binding to the channels underlying I(A) can result in effects on firing patterns opposite to those expected from simple block of I(A)...
  61. ncbi Biophysical characterization of whole-cell currents in O2-sensitive neurons from the rat glossopharyngeal nerve
    V A Campanucci
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    Neuroscience 132:437-51. 2005
    ..These properties endow GPN neurons with an exquisite ability to regulate carotid body chemoreceptor function during hypoxia, via voltage-gated Ca2+-entry, activation of nNOS, and release of NO...
  62. ncbi Nuclear factor-kappaB activation by reactive oxygen species mediates voltage-gated K+ current enhancement by neurotoxic beta-amyloid peptides in nerve growth factor-differentiated PC-12 cells and hippocampal neurones
    Anna Pannaccione
    Division of Pharmacology, Department of Neuroscience, School of Medicine, Federico II University of Naples, Naples, Italy
    J Neurochem 94:572-86. 2005
    ....
  63. ncbi Direct evidence for mutual interactions between perineuronal astrocytes and interneurons in the CA1 region of the rat hippocampus
    Y Yamazaki
    Department of Neurophysiology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Neuroscience 134:791-802. 2005
    ..These results directly demonstrate the existence of bidirectional interactions between neurons and perineuronal astrocytes...
  64. ncbi Optical monitoring of progressive synchronization in dentate granule cells during population burst activities
    Masanori Murayama
    Laboratory of Cellular Neurobiology, School of Life Science, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Eur J Neurosci 21:3349-60. 2005
    ..This progressive synchronization may be a key feature in making self-organizing neuronal networks...
  65. ncbi Potassium currents in isolated statocyst neurons and RPeD1 in the pond snail, Lymnaea stagnalis
    Manabu Sakakibara
    Laboratory of Neurobiological Engineering, Department of Biological Science and Technology, School of High Technology for Human Welfare, Tokai University, Numazu, Shizuoka, Japan
    J Neurophysiol 94:3884-92. 2005
    ..I(A) in hair cells is also smaller in amplitude than in RPeD1 and is activated at more depolarized potentials. In like manner, I(KV) is smaller in hair cells and is activated at more depolarized potentials than in RPeD1...
  66. ncbi Ca2+-activated K+-current density is correlated with soma size in rat vestibular-afferent neurons in culture
    Agenor Limon
    Institute of Physiology, Autonomous University of Puebla, Mexico
    J Neurophysiol 94:3751-61. 2005
    ....
  67. pmc A-type potassium current in retinal arteriolar smooth muscle cells
    Mary K McGahon
    Centre of Vision Sciences, The Queen s University of Belfast, Institute of Clinical Sciences, The Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland
    Invest Ophthalmol Vis Sci 46:3281-7. 2005
    ..The goal of the present study was to identify and characterize the A-type K(+) current in retinal microvascular smooth muscle (MVSM) and to examine its role in modulating membrane potential and cellular contractility...
  68. ncbi Phasic stimuli evoke precisely timed spikes in intermittently discharging mitral cells
    Ramani Balu
    Dept of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Neurophysiol 92:743-53. 2004
    ..These intrinsic properties of mitral cells may be important for precisely timing spikes evoked by phasic stimuli that occur in response to odor presentation in vivo...
  69. ncbi Potassium channels in human umbilical artery cells
    Veronica Milesi
    Anatomía y Fisiología, Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina
    J Soc Gynecol Investig 10:339-46. 2003
    ..To identify K+ channels of smooth muscle of human umbilical artery using the patch-clamp technique and to study their effect on resting tone of umbilical artery rings...
  70. ncbi Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal
    Taro Ishikawa
    Department of Neurophysiology, University of Tokyo Graduate School of Medicine, Tokyo 113 0033, Japan
    J Neurosci 23:10445-53. 2003
    ..We conclude that both Kv3 and Kv1 channels contribute differentially to maintaining the fidelity of synaptic transmission at the calyx of Held...
  71. ncbi Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons
    K Dang
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 286:G573-9. 2004
    ..83.6 +/- 2.2 mV) associated with an acceleration of inactivation kinetics. These data suggest that a reduction in K(+) currents contributes, in part, to increased neuron excitability that may lead to development of dyspeptic symptoms...
  72. ncbi [Changes of potassium channel activity of hindlimb arterial smooth muscle cells in tail-suspended rats]
    Zhao Jun Fu
    Space Med Med Eng (Beijing) 16:253-6. 2003
    ....
  73. ncbi Biophysical properties and metabolic regulation of a TASK-like potassium channel in rat carotid body type 1 cells
    Beatrice A Williams
    University Laboratory of Physiology, Parks Rd, Oxford 0X1 3PT, UK
    Am J Physiol Lung Cell Mol Physiol 286:L221-30. 2004
    ....
  74. ncbi Altered outward K(+) currents in Drosophila larval neurons of memory mutants rutabaga and amnesiac
    D Yu
    Laboratory of Visual Information Processing, Department of Neurobiology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    J Neurobiol 40:158-70. 1999
    ..Arachidonic acid, a specifical inhibitor of Kv4 family (shal) K(+) channels, was found to inhibit K(+) currents in cultured Drosophila neurons, suggesting the presence of shal channels in these neurons...
  75. ncbi Potassium currents in primary cultured astrocytes from the rat corpus callosum
    Daniel Reyes-Haro
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro, 76230, Mexico
    J Neurocytol 34:411-20. 2005
    ..These results may help to understand better the roles of voltage-activated K(+)-currents in astrocytes from the rat CC in particular and glial cells in general...
  76. ncbi Amyloid beta-protein fragment 31-35 suppresses delayed rectifying potassium channels in membrane patches excised from hippocampal neurons in rats
    Jin Shun Qi
    Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China
    Synapse 51:165-72. 2004
    ....
  77. ncbi Transforming growth factor-alpha changes firing properties of developing neocortical GABAergic neurons by down-regulation of voltage-gated potassium currents
    H Namba
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Neuroscience 122:637-46. 2003
    ..Thus, chronic treatment with TGFalpha down-regulated slow delayed rectifier and transient voltage-gated potassium currents, and in parallel, suppressed repetitive generation of action potentials in the cortical GABAergic neurons...
  78. pmc Heterogeneous potassium conductances contribute to the diverse firing properties of postnatal mouse vestibular ganglion neurons
    Jessica R Risner
    Department of Neuroscience, University of Virginia, MR4, Room 5126, Box 801392, Charlottesville, VA 22908 1392, USA
    J Neurophysiol 96:2364-76. 2006
    ..The mean low-pass corner (about 29 Hz) was determined by the membrane time constant. Together these factors contributed to the sharply tuned, band-pass characteristics intrinsic to postnatal vestibular ganglion neurons...
  79. ncbi PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP
    Y A Mei
    Department of Physiology, School of Life Science, Fudan University, Shanghai 200433, China
    Eur J Neurosci 19:1446-58. 2004
    ....
  80. ncbi Demonstration of calcium-activated transient outward chloride current and delayed rectifier potassium currents in Swine atrial myocytes
    Gui Rong Li
    Department of Medicine Institute of Cardiovascular Science and Medicine, L8 01, Laboratory Block, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China
    J Mol Cell Cardiol 36:495-504. 2004
    ....
  81. ncbi Nitrergic relaxation in urethral smooth muscle: involvement of potassium channels and alternative redox forms of NO
    G Costa
    Departamento de Fisiologia, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Naunyn Schmiedebergs Arch Pharmacol 364:516-23. 2001
    ..In addition, the production and/or release of alternative redox forms of NO, such as NO-, may be involved in neurotransmission processes in the urethra...
  82. ncbi Calcium-dependent potentials with different sensitivities to calcium agonists and antagonists in guinea-pig hippocampal neurons
    H Higashi
    Department of Physiology, Kurume University School of Medicine, Japan
    Neuroscience 34:35-47. 1990
    ..abstract truncated at 400 words)..
  83. pmc Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 111:687-94. 1994
    ..Glibenclamide-sensitive K channels take part in determining action potential shape and duration in the guinea-pig ureter...
  84. ncbi Mechanisms involved in the relaxant action of the ethanolic extract of propolis in the guinea-pig trachea in-vitro
    Niraldo Paulino
    Grupo de Pesquisa e Desenvolvimento de Biofármacos, Universidade do Sul de Santa Catarina, Tubarao, Brasil
    J Pharm Pharmacol 54:845-52. 2002
    ..Furthermore, the stimulation of beta2-adrenergic and VIP receptors also seems to account for its relaxant action...
  85. ncbi Potassium channel blockade of atrial negative inotropic responses to P1-purinoceptor and muscarinic receptor agonists and to cromakalim
    R A Urquhart
    Department of Pharmacology, Welsh School of Pharmacy, University of Wales College of Cardiff
    J Cardiovasc Pharmacol 21:279-88. 1993
    ..These channels differ from the ATP-regulated potassium channels activated by cromakalim...
  86. pmc Subtype classification of the presynaptic alpha-adrenoceptors which regulate [3H]-noradrenaline secretion in guinea-pig isolated urethra
    P Alberts
    Department of Receptor Pharmacology, Urology and Gynaecology, Kabi Pharmacia Therapeutics, Stockholm, Sweden
    Br J Pharmacol 105:142-6. 1992
    ..The secretion is not influenced by compounds acting at beta-adrenoceptors, muscarinic cholinoceptors or adenosine receptors...
  87. ncbi Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels
    Ute Lindauer
    Experimental Neurology, Charite, Humboldt Universitat, Berlin, Germany
    J Cereb Blood Flow Metab 23:1227-38. 2003
    ....
  88. ncbi Role of K+ channels in augmented relaxations to sodium nitroprusside induced by mexiletine in rat aortas
    H Kinoshita
    Department of Anesthesia, Japanese Red Cross Society, Wakayama Medical Center, Japan
    Anesthesiology 92:813-20. 2000
    ....
  89. pmc Pharmacological characterization of muscarinic receptor-activated cation channels in guinea-pig ileum
    S Chen
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 109:793-801. 1993
    ..The mechanism of inhibition and the relevance to use of these drugs as blockers for the I cat channel are discussed...
  90. pmc Potassium channel blockers differentially affect carbachol and (-)-N6-phenylisopropyladenosine on guinea-pig atria
    M De Biasi
    Department of Pharmacology, University of Padua, Padova, Italy
    Br J Pharmacol 97:866-72. 1989
    ..In contrast, carbachol had no effect. 5. In agreement with our previous study, the data suggest that R-PIA acts on isolated atria by inhibiting Ca2+ influx through L-channels...
  91. pmc Calcium channel subtypes contributing to acetylcholine release from normal, 4-aminopyridine-treated and myasthenic syndrome auto-antibodies-affected neuromuscular junctions
    F Giovannini
    Neuroscience Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington OX3 9DU, UK
    Br J Pharmacol 136:1135-45. 2002
    ..4 Altogether, these data demonstrate that multiple VDCC subtypes are present at the mouse NMJ and that a resistant component can be identified under 'pharmacological' and/or 'pathological' conditions...
  92. ncbi Synaptic and nonsynaptic contributions to giant ipsps and ectopic spikes induced by 4-aminopyridine in the hippocampus in vitro
    R D Traub
    Department of Pharmacology, Division of Neuroscience, University of Birmingham School of Medicine, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Neurophysiol 85:1246-56. 2001
    ..We conclude that in 4-AP, axonal gap junctions could, at least in principle, account in part for both the large IPSPs, and for the antidromic activity in pyramidal neurons...
  93. pmc Control of glutamate release by calcium channels and kappa-opioid receptors in rodent and primate striatum
    M P Hill
    Manchester Movement Disorders Laboratory, Division of Neuroscience, School of Biological Sciences, University of Manchester
    Br J Pharmacol 127:275-83. 1999
    ..In conclusion, the results presented suggest that there are species differences in the control of glutamate release by kappa-opioid receptors and Ca2+ -channels...
  94. pmc Potassium currents in human freshly isolated bronchial smooth muscle cells
    V A Snetkov
    Respiratory Research Laboratories, Department of Allergy and Respiratory Medicine, UMDS, London
    Br J Pharmacol 115:1117-25. 1995
    ..The Ca2+- and voltage-dependency of this channel may well allow a sufficiently high open state probability for it to play a partin the regulation of the resting membrane potential...
  95. ncbi Hypoxic vasoconstriction of rat main pulmonary artery: role of endogenous nitric oxide, potassium channels, and phosphodiesterase inhibition
    M Bardou
    Laboratory of Cardiovascular Physiopathology and Pharmacology, Faculty of Medicine, Dijon, France
    J Cardiovasc Pharmacol 38:325-34. 2001
    ....
  96. ncbi Mechanisms of alpha,beta-methylene atp-induced inhibition in rat ileal smooth muscle: involvement of intracellular Ca2+ stores in purinergic inhibition
    M Storr
    Department of Internal Medicine, Technical University of Munich, Germany
    Clin Exp Pharmacol Physiol 27:771-9. 2000
    ....
  97. pmc Differential effects of K+ channel blockers on antinociception induced by alpha 2-adrenoceptor, GABAB and kappa-opioid receptor agonists
    M Ocana
    Department of Pharmacology, School of Medicine, University of Granada, Spain
    Br J Pharmacol 110:1049-54. 1993
    ..The K+ channels opened by alpha2-adrenoceptor agonists seem to be ATP-dependent channels, whereas those opened by GABAB receptor agonists are not...
  98. ncbi Effects of three different L-type Ca2+ entry blockers on airway constriction induced by muscarinic receptor stimulation
    K Hirota
    Department of Anesthesiology, University of Hirosaki, School of Medicine, Japan
    Br J Anaesth 90:671-5. 2003
    ..In this study, we examined the effects of the dihydropyridines nifedipine and nicardipine, the benzothiazepine diltiazem, and the phenylalkylamine verapamil on airway constriction...
  99. pmc Inhibitory effect of 4-aminopyridine on responses of the basilar artery to nitric oxide
    C G Sobey
    Department of Pharmacology, The University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 126:1437-43. 1999
    ..The most likely mechanism would appear to be activation of voltage-dependent K+ channels by NO/cyclic GMP...
  100. ncbi Antagonism of some cyclohexamine-based drug combinations used for chemical restraint of southern elephant seals (Mirounga leonina)
    R Woods
    School of Pharmacy, University of Tasmania
    Aust Vet J 72:165-71. 1995
    ..0 mg/kg, diazepam = 0.03 mg/kg) and ketamine and xylazine, and should be contraindicated. Doxapram (5.0 mg/kg) was the most useful general antagonist for all groups of drugs but shaking was seen and a lower dose is recommended...
  101. ncbi Anticonvulsive action of (+/-)-kavain estimated from its properties on stimulated synaptosomes and Na+ channel receptor sites
    J Gleitz
    University Clinics Ulm, Institute of Naturheilkunde, Germany
    Eur J Pharmacol 315:89-97. 1996
    ..The data suggest an interaction of (+/-)-kavain with voltage-dependent Na+ and Ca2+ channels, thereby suppressing the 4-aminopyridine-induced increase in [Na+]i, [Ca2+]i and the release of endogenous glutamate...

Research Grants59

  1. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ....
  2. O2 sensing in the human and rabbit ductus arteriosus.
    Stephen L Archer; Fiscal Year: 2013
    ..Since HOSK may have arisen independent of the canonical K+ channel family, exploring its structure-function relationship will extend our fundamental knowledge K+ channels. ..
  3. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    ....
  4. Femtosecond laser-produced sub-surface cuts to halt focal epileptic seizures
    Theodore H Schwartz; Fiscal Year: 2013
    ..This is particularly true because the patients who are not able to control their seizures well with medication tend to have the kind of focally-initiated seizures that the therapy we propose would be best to treat. ..
  5. Regulation of Kv Channels by Anorexigens
    Bruce Pitt; Fiscal Year: 2007
    ..1 proteins, inhibition of Kv1.5 gene transcription and blockade of Kv currents at plasma membrane. ..
  6. Drug-Induced Motor Recovery After Spinal Cord Injury
    Kwaku Nantwi; Fiscal Year: 2005
    ..abstract_text> ..
  7. Two-Photon Subpial Transections: Neocortical Epilepsy
    THEODORE SCHWARTZ; Fiscal Year: 2004
    ..abstract_text> ..
  8. EARLY RESPONSE OF CORNEAL EPITHELIUM TO UV-INDUCED DEATH
    Luo Lu; Fiscal Year: 2004
    ..Furthermore therapeutic measures may be identified which could reduce the incidence of UV-induced apoptotic corneal epithelial damage and increases in corneal epithelial susceptibility to infection and diseases. ..
  9. PERIPHERAL NEUROPATHY FOLLOWING THERMAL INJURY
    WILLIAM MONAFO; Fiscal Year: 1991
    ..Functional consultative associations have been developed with neurobiologists with relevant expertise...
  10. ION CHANNELS IN DEMYELINATING DISEASES
    Betty Soliven; Fiscal Year: 2003
    ..In addition, there may be ways to promote remyelination using the K+ channels of OP cells/OLGs as drug targets. ..
  11. SPINAL MOTOR CONDUCTION AND RECOVERY AFTER HUMAN SCI
    Blair Calancie; Fiscal Year: 2009
    ..A slow-release formulation the K-channel blocker 4-aminopyridine will be tested for its effects on conduction in some cases. ..
  12. MOLECULAR PHYSIOLOGY OF POTASSIUM CHANNEL GATING
    LINDA BOLAND; Fiscal Year: 2000
    ..This will be useful in understanding the molecular basis for excitation and signaling in nerve and muscle and may also have therapeutic use in the design of drugs that target certain functional regions of the channel protein. ..
  13. PLASTICITY AT A CRAYFISH NEUROMUSCULAR SYNAPSE
    Jen Wei Lin; Fiscal Year: 2003
    ....
  14. Transmitter Repletion: Key to Phrenic-Diaphragm Function
    Erik van Lunteren; Fiscal Year: 2005
    ..These studies may lead to novel therapeutic approaches to respiratory muscle impairment and resulting hypercapnic respiratory failure for conditions which produce neuromuscular junction dysfunction. ..
  15. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  16. PHYSIOLOGY OF APOPTOTIC NEURONAL INJURY IN VITRO
    Steven Rothman; Fiscal Year: 2001
    ..Most important, they will provide direct evidence for the recruitment of apoptotic pathways in ischemic human brain. ..
  17. NEW STRATEGIES FOR NEOCORTICAL EPILEPSY
    Steven Rothman; Fiscal Year: 2007
    ..If Peltier devices can control focal seizures in our models, they will be refined for future experiments to investigate their potential role in mapping and controlling epileptogenic neocortex in man. [unreadable] [unreadable]..
  18. Dissection of Ethanol Actions on Cholinergic Nerve Endings
    TIMOTHY SEARL; Fiscal Year: 2008
    ..Our preliminary data with botulinums toxins demonstrate that the synaptic vesicle protein synaptobrevin is an important target for the effects of ethanol. [unreadable] [unreadable] [unreadable] [unreadable]..
  19. IMAGING BETA CELL FUNCTION WITH BIOSENSORS
    Louis Philipson; Fiscal Year: 2007
    ..The studies will provide new understanding of islet cell biology that will benefit clinical strategies to preserve and maintain functional 13-cell mass. ..
  20. Role of NTS POMC neurons in energy homeostasis
    SUZANNE APPLEYARD; Fiscal Year: 2008
    ..abstract_text> ..
  21. Synaptic Integration in Radial Oblique dendrites
    Sonia Gasparini; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  22. Dopamine modulation of network activity in the prefrontal cortex.
    Sven Kroener; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Calcium Signaling in Suprachiasmatic Nucleus Neurons
    CHARLES ALLEN; Fiscal Year: 2008
    ..Together, these experiments will identify the early steps in the light-signaling pathway, thus contributing to a better understanding of the cellular basis of circadian rhythms. ..
  24. Neurotransmission at the vestibular calyx synapse
    KATHERINE RENNIE; Fiscal Year: 2007
    ..The combination of experimental & modeling approaches will elucidate how sensory information is transformed by HC1 & converted into a neural code by their afferents. ..
  25. CRCNS: Input/Output Relationship in CA3 Pyramidal Cells
    Giorgio Ascoli; Fiscal Year: 2008
    ..In addition to the dissemination of results in conferences and peer-reviewed publications, all models will be publicly distributed through internet archives. ..
  26. CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NO
    Cristine L Heaps; Fiscal Year: 2010
    ....
  27. Real-time MRI-guided RF Ablation of Cardiac TachyArrhythmias
    Orhan Unal; Fiscal Year: 2010
    ..Successful completion of this project is expected to improve safety, simplicity, and efficacy catheter ablation procedure to treat AF. ..
  28. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2010
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  29. Low-level toxicant perturbation of neural cell function
    Mark D Noble; Fiscal Year: 2010
    ....
  30. Prostanoids and hypoxic neonatal pulmonary hypertension
    CANDICE FIKE; Fiscal Year: 2009
    ..The goal of this project is to help us understand why infants develop pulmonary hypertension, determine what happens in the lung blood vessels during disease development, and develop treatments for this disease. ..
  31. Collicular influence on auditory thalamic neurons
    Philip Smith; Fiscal Year: 2009
    ..The proposed experiments will help to answer these questions. ..
  32. In Vivo Analysis of Synaptic Function in Zebrafish
    Hua Wen; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  33. EDHF in the Cerebral Circulation
    ROBERT BRYAN; Fiscal Year: 2009
    ..Furthermore, we anticipate that new information regarding tandem pore domain potassium channels will be a big step in the understanding of cerebral circulatory control. ..
  34. Novel Approaches for Burn Injury Cardiac Dysfunction
    Atsuko Yatani; Fiscal Year: 2009
    ..D. The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  35. CELLULAR AND MOLECULAR STUDIES OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 2007
    ..The two specific aims of this project are linked in that one drives studies of the the effector pKir2.1 and the second directs studies the msucarinic receptors in the pathway proposed above. ..
  36. HYPERTENSION: CONTRIBUTION OF ARTERIAL WALL CHANGES
    Robert Cox; Fiscal Year: 2007
    ..These studies will define a novel therapeutic target for antihypertensive drug development based upon the mechanism(s) of Ca2+-Kv channel modulation. ..
  37. Dendritic Processing in the Olfactory Bulb
    Jason Christie; Fiscal Year: 2003
    ..The specific aims are: (1) to determine the function of autoexcitation in mitral cell processing and (2) to determine how dendritic compartmentalization effects mitral cell processing. ..
  38. IONIC CURRENTS AND AUTONOMIC REGULATION IN HEART FAILURE
    Atsuko Yatani; Fiscal Year: 2002
    ....
  39. ACTIVATION AND TERMINATION OF CA RELEASE IN HEART CELLS
    JAMES SHAM; Fiscal Year: 2003
    ..This project will provide important information on the mechanistic control and regulation of cardiac excitation contraction coupling. ..
  40. SECRETORY FUNCTION OF PANCREATIC DUCT CELLS
    Toan Nguyen; Fiscal Year: 2003
    ..b) characterize the vectorial release of ATP release from PDEC (autocrine action) c) study the effect of mast cell degranulation, resulting in ATP release, on PDEC secretion (paracrine action). ..
  41. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..Frequent consultation with a neurosurgeon, who is a member of the research team, will provide necessary input to direct the study and experiments towards clinically relevant solutions for transection nerve injuries. ..
  42. Direct Enantiomer Separation in Immunoaffinity Systems
    Oliver Hofstetter; Fiscal Year: 2003
    ..Chromatographic parameters will be optimized in order to adjust separation conditions to the strength of interaction between antibody and analyte. ..
  43. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 2001
    ....
  44. PRECURSOR CELL RENEWAL, OLIGODENDROCYTES & REMYELINATION
    Mark Noble; Fiscal Year: 2001
    ....
  45. PRESYNAPTIC MECHANISMS IN THE SUPRACHIASMATIC NUCLEUS
    CHARLES ALLEN; Fiscal Year: 2004
    ..4) Investigate whether there are co-operative interactions between presynaptic neurotransmitter receptors regulating glutamate release from RHT terminals. ..
  46. NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLE
    Christopher Rembold; Fiscal Year: 2004
    ....
  47. Dynamics of thalamo-cortico-thalamic networks
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2007
    ..abstract_text> ..
  48. Excitatory GABA, Interneuron Networks, and Epilepsy
    KATHERINE PERKINS; Fiscal Year: 2007
    ..abstract_text> ..
  49. Restoring Conduction in Chronically Injured Spinal Cord
    Daniel Smith; Fiscal Year: 2006
    ..The results generated by the proposed study will serve as the foundation for additional pre-clinical development that will advance novel treatments of chronic SCI toward the human clinic. [unreadable] [unreadable]..
  50. MOLECULAR PHYSIOLOGY OF POTASSIUM CHANNELS
    Gary Yellen; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  51. Expression & function of channelrhodopsins in the retina
    Zhuo Hua Pan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  52. Retinal Synaptic Transmission: Channels and Transmitters
    Zhuo Hua Pan; Fiscal Year: 2005
    ..The understanding of the role of voltage-activated Ca2+ channels in synaptic transmission may also provide insight for identifying the mechanism of diseases caused by synaptic dysfunction. ..
  53. CNS PRECURSOR CELL DYSFUNCTION IN DEVELOPMENTAL MALADIES
    Mark Noble; Fiscal Year: 2005
    ..abstract_text> ..
  54. Oligodendrocytes & precursors: toxicity of chemotherapy
    Mark Noble; Fiscal Year: 2005
    ..In addition, we will identify and test means of selectively protecting normal cells from such damage without simultaneously protecting cancer cells in vitro as well as in vivo. ..
  55. P20-Mediated Suppression of Vascular Force
    Christopher Rembold; Fiscal Year: 2004
    ..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..
  56. FLOW INDUCED DILATIONS IN CEREBRAL VESSELS
    ROBERT BRYAN; Fiscal Year: 2001
    ..Furthermore, insight into the consequences of ischemia/reperfusion on flow-induced dilations in the cerebral circulation could lead to a therapeutic strategy for improving maintenance of cerebral perfusion after stroke. ..