sertraline

Summary

Summary: A selective serotonin uptake inhibitor that is used in the treatment of depression.

Top Publications

  1. ncbi Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial
    Sube Banerjee
    Institute of Psychiatry, Health Services and Population Research Department, King s College London, London, UK
    Lancet 378:403-11. 2011
  2. ncbi Sertraline increases extracellular levels not only of serotonin, but also of dopamine in the nucleus accumbens and striatum of rats
    Yuji Kitaichi
    Department of Molecular Stressphysiology, Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Pharmacol 647:90-6. 2010
  3. ncbi Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    N Engl J Med 354:1231-42. 2006
  4. ncbi Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University Vienna, MUV, AKH, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    J Clin Psychiatry 71:109-20. 2010
  5. ncbi Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment
    M Fava
    Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 61:863-7. 2000
  6. ncbi Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy
    Victor L Serebruany
    Sinai Center for Thrombosis Research, Johns Hopkins University, Baltimore, MD 21215, USA
    Circulation 108:939-44. 2003
  7. ncbi Analysis of association between the 5-HTTLPR and STin2 polymorphisms in the serotonin-transporter gene and clinical response to a selective serotonin reuptake inhibitor (sertraline) in patients with premature ejaculation
    Mohammad Reza Safarinejad
    Urology and Nephrology Research Centre, Shahid Beheshti University MC, Tehran, Iran
    BJU Int 105:73-8. 2010
  8. pmc Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 56:692-9. 2010
  9. pmc Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine
    Francesco Matrisciano
    Department of Psychiatry and Psychological Medicine, University of Rome La Sapienza Sant Andrea Hospital, Via di Grottarossa, 1035 1039, 00189 Rome, Italy
    J Psychiatr Res 43:247-54. 2009
  10. pmc Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Dis 30:312-22. 2008

Detail Information

Publications308 found, 100 shown here

  1. ncbi Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial
    Sube Banerjee
    Institute of Psychiatry, Health Services and Population Research Department, King s College London, London, UK
    Lancet 378:403-11. 2011
    ..We aimed to assess efficacy and safety of two of the most commonly prescribed drugs, sertraline and mirtazapine, compared with placebo.
  2. ncbi Sertraline increases extracellular levels not only of serotonin, but also of dopamine in the nucleus accumbens and striatum of rats
    Yuji Kitaichi
    Department of Molecular Stressphysiology, Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Pharmacol 647:90-6. 2010
    ..We examined effects of sertraline, fluvoxamine, and paroxetine on extracellular serotonin, dopamine, and noradrenaline levels in the medial ..
  3. ncbi Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    N Engl J Med 354:1231-42. 2006
    ..After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective than switching to another...
  4. ncbi Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University Vienna, MUV, AKH, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    J Clin Psychiatry 71:109-20. 2010
    ..first antidepressant to be an agonist at MT(1)/MT(2) receptors and an antagonist at 5-HT(2C) receptors, versus sertraline with regard to the amplitude of the circadian rest-activity cycle and depressive and anxiety symptoms in ..
  5. ncbi Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment
    M Fava
    Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 61:863-7. 2000
    ..Also unknown is whether different agents have differential effects. To examine these questions, we assessed weight changes in patients randomly assigned to long-term treatment with fluoxetine, sertraline, or paroxetine.
  6. ncbi Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy
    Victor L Serebruany
    Sinai Center for Thrombosis Research, Johns Hopkins University, Baltimore, MD 21215, USA
    Circulation 108:939-44. 2003
    ..Accordingly, we serially assessed the release of established platelet/endothelial biomarkers in patients treated with sertraline vs placebo in the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART).
  7. ncbi Analysis of association between the 5-HTTLPR and STin2 polymorphisms in the serotonin-transporter gene and clinical response to a selective serotonin reuptake inhibitor (sertraline) in patients with premature ejaculation
    Mohammad Reza Safarinejad
    Urology and Nephrology Research Centre, Shahid Beheshti University MC, Tehran, Iran
    BJU Int 105:73-8. 2010
    ....
  8. pmc Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 56:692-9. 2010
    The objective was to test the hypothesis that heart failure (HF) patients treated with sertraline will have lower depression scores and fewer cardiovascular events compared with placebo.
  9. pmc Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine
    Francesco Matrisciano
    Department of Psychiatry and Psychological Medicine, University of Rome La Sapienza Sant Andrea Hospital, Via di Grottarossa, 1035 1039, 00189 Rome, Italy
    J Psychiatr Res 43:247-54. 2009
    ..We assessed serum BDNF levels in 21 patients with major depressive episode treated with sertraline, escitalopram, or venlafaxine and 20 healthy controls. Serum samples were collected between 10 a.m. and 12 p.m...
  10. pmc Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Dis 30:312-22. 2008
    ..and can be administered long term with few side effects in Huntington's disease, we investigated the effect of sertraline, a selective serotonin reuptake inhibitor (SSRI) which has been shown to upregulate BDNF levels in rodent brains...
  11. ncbi Sertraline treatment of major depression in patients with acute MI or unstable angina
    Alexander H Glassman
    Department of Clinical Psychopharmacology, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 116, New York, NY 10032, USA
    JAMA 288:701-9. 2002
    ..However, no published evidence exists that antidepressant drugs are safe or efficacious in patients with unstable ischemic heart disease...
  12. ncbi A randomized, placebo-controlled trial of sertraline in the treatment of night eating syndrome
    John P O'Reardon
    Department of Psychiatry, University of Pennsylvania, Rm 4005, 3535 Market St, Philadelphia, PA 19104, USA
    Am J Psychiatry 163:893-8. 2006
    The authors assessed the efficacy of sertraline in the treatment of night eating syndrome.
  13. ncbi Behavioural signs of depression and apoptosis in the limbic system following myocardial infarction: effects of sertraline
    B P Wann
    Centre de Recherche, Hôpital Sacré Coeur de Montréal, Montreal, Canada
    J Psychopharmacol 23:451-9. 2009
    ..We measured the effects of the antidepressant sertraline on behavioural and biochemical events following MI in a rat model...
  14. ncbi An evidence-based review of the clinical use of sertraline in mood and anxiety disorders
    David V Sheehan
    University of South Florida College of Medicine, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    Int Clin Psychopharmacol 24:43-60. 2009
    b>Sertraline is a selective serotonin reuptake inhibitor that has been used and studied extensively throughout the world and found to be safe and well tolerated in numerous patient populations, including those with either psychiatric and/or ..
  15. ncbi The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial
    Andre R Brunoni
    Clinical Research Center, University Hospital, Sao Paulo, Brazil
    JAMA Psychiatry 70:383-91. 2013
    ..Transcranial direct current stimulation (tDCS) trials for major depressive disorder (MDD) have shown positive but mixed results...
  16. ncbi Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind, placebo-controlled study
    J Davidson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 158:1974-81. 2001
    The study examined the efficacy of sertraline, compared with placebo, in sustaining improvement and preventing relapse over 28 weeks in patients with posttraumatic stress disorder (PTSD) who had completed a 12-week double-blind, placebo-..
  17. ncbi Efficacy of sertraline in severe generalized social anxiety disorder: results of a double-blind, placebo-controlled study
    Michael R Liebowitz
    New York State Psychiatric Institute, New York, NY, USA
    J Clin Psychiatry 64:785-92. 2003
    ..The goal of the current study was to evaluate the efficacy and tolerability of sertraline for the treatment of severe generalized social anxiety disorder in adults.
  18. ncbi Antidepressant side effects in depression patients treated in a naturalistic setting: a study of bupropion, moclobemide, paroxetine, sertraline, and venlafaxine
    J D Vanderkooy
    Queen s University, Kingston, Ontario
    Can J Psychiatry 47:174-80. 2002
    ..There is no commonly accepted standard for comparing antidepressant-induced side effects. This study evaluates a clinician-administered scale, the Toronto Side Effect Scale (TSES), in a natural practice clinic...
  19. pmc The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model
    Qi Peng
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Exp Neurol 210:154-63. 2008
    ..Here we report that an SSRI antidepressant, sertraline, prolongs survival, improves motor performance, and ameliorates brain atrophy in the R6/2 HD mouse model...
  20. ncbi Pramipexole versus sertraline in the treatment of depression in Parkinson's disease: a national multicenter parallel-group randomized study
    Paolo Barone
    Department of Neurological Sciences, University of Naples Federico II, Via Pansini 5, 80131, Napoli, Italy
    J Neurol 253:601-7. 2006
    ..5 to 4.5 mg/day) or sertraline (at 50 mg/day)...
  21. ncbi Association between serotonin transporter gene promoter-region polymorphism and 4- and 12-week treatment response to sertraline in posttraumatic stress disorder
    Dhuha Mushtaq
    Department of Biotechnology, Jamia Millia, New Delhi, India
    J Affect Disord 136:955-62. 2012
    We examined the association between serotonin transporter (5HTTLPR) genotype (SS vs SL vs LL) and sertraline treatment outcome in posttraumatic stress disorder (PTSD).
  22. pmc Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo
    R Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA rima kaddurahdaouk duke edu
    Transl Psychiatry 3:e223. 2013
    In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD)...
  23. ncbi Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine
    Rena Cooper-Kazaz
    Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Affect Disord 116:113-6. 2009
    ..Triiodothyronine (T3) is used to potentiate the clinical effect of antidepressant drugs. Inter-individual differences in efficacy may be related to genetically-based variability in thyroid function...
  24. ncbi Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study
    R Scott Obach
    Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Groton Laboratories, Pfizer, Inc, Groton, CT 06340, USA
    Drug Metab Dispos 33:262-70. 2005
    The oxidative and conjugative metabolism of sertraline was examined in vitro to identify the enzymes involved in the generation of N-desmethyl, deaminated, and N-carbamoyl-glucuronidated metabolites in humans...
  25. ncbi Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial
    Renee Romeo
    Brighton and Sussex Medical School, University of Sussex, Brighton, East Sussex, UK
    Br J Psychiatry 202:121-8. 2013
    ..Depression is a common and costly comorbidity in dementia. There are very few data on the cost-effectiveness of antidepressants for depression in dementia and their effects on carer outcomes...
  26. pmc A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
    Arch Gen Psychiatry 66:838-47. 2009
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  27. ncbi Impact of early administration of sertraline on cognitive and behavioral recovery in the first year after moderate to severe traumatic brain injury
    James H Banos
    Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    J Head Trauma Rehabil 25:357-61. 2010
    To assess the efficacy of sertraline administered in the first 3 months after moderate to severe traumatic brain injury (TBI) in improving cognitive and behavioral outcomes.
  28. ncbi Aquatic toxicity of sertraline to Pimephales promelas at environmentally relevant surface water pH
    Theodore W Valenti
    Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX 76798, USA
    Environ Toxicol Chem 28:2685-94. 2009
    ..employed 48-h and 7-d toxicity tests with Pimephales promelas exposed to the model weak base pharmaceutical sertraline over a gradient of environmentally relevant surface water pHs...
  29. ncbi Effect of sertraline on [Ca2+](i) and viability of human MG63 osteosarcoma cells
    Ko Long Lin
    Department of Rehabilitation, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Drug Chem Toxicol 36:231-40. 2013
    The antidepressant, sertraline, has been shown to have diverse in vitro effects. This study examined whether sertraline altered [Ca(2+)](i) in MG63 human osteosarcoma cells by using fura-2 as a Ca(2+)-sensitive fluorescent dye...
  30. ncbi Complex modulation of human motor cortex excitability by the specific serotonin re-uptake inhibitor sertraline
    Tihomir V Ilic
    Department of Neurology, J W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Franfurt am Main, Germany
    Neurosci Lett 319:116-20. 2002
    ..Here, the effects of a single oral dose (100mg) of the selective serotonin re-uptake inhibitor sertraline on human motor cortex excitability were investigated in healthy subjects...
  31. ncbi Adverse events in users of sertraline: results from an observational study in psychiatric practice in The Netherlands
    Welmoed E E Meijer
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, PO Box 80 082, 3508 TB Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 11:655-62. 2002
    To evaluate the safety profile of sertraline versus other Selective Serotonin Reuptake Inhibitors (SSRIs) directly following the introduction of sertraline to the Dutch market.
  32. ncbi The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Petah Tikva, Israel
    Neuroimmunomodulation 18:117-22. 2011
    ..We have previously demonstrated the immunomodulatory activity of some selective serotonin reuptake inhibitors...
  33. ncbi Predictive factors for responding to sertraline treatment: views from plasma catecholamine metabolites and serotonin transporter polymorphism
    Wakako Umene-Nakano
    Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyusyu, Fukuoka, Japan
    J Psychopharmacol 24:1764-71. 2010
    In the present study, we investigated the effects of sertraline on plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and serum brain-derived neurotrophic factor (BDNF) levels in 59 depressed patients ..
  34. ncbi Human therapeutic plasma levels of the selective serotonin reuptake inhibitor (SSRI) sertraline decrease serotonin reuptake transporter binding and shelter-seeking behavior in adult male fathead minnows
    Theodore W Valenti
    The Institute of Ecological, Earth, and Environmental Sciences, Baylor University, Waco, Texas 76798, United States
    Environ Sci Technol 46:2427-35. 2012
    ..We selected sertraline as a model SSRI for a 28-d study with adult male fathead minnows...
  35. ncbi The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling
    Chen Ju Lin
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
    Cancer Res 70:3199-208. 2010
    b>Sertraline, a selective serotonin reuptake inhibitor, is a widely used antidepressant agent. Here, we show that sertraline also exhibits antiproliferative activity...
  36. ncbi Block of persistent late Na+ currents by antidepressant sertraline and paroxetine
    Ging Kuo Wang
    Department of Anesthesia, Harvard Medical School and Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Membr Biol 222:79-90. 2008
    ..In this report, we examined the effects of contemporary antidepressants sertraline and paroxetine on (1) neuronal Na+ channels expressed in GH3 cells and (2) muscle rNav1...
  37. ncbi Sertraline vs. ELectrical Current Therapy for Treating Depression Clinical Trial--SELECT TDCS: design, rationale and objectives
    Andre Russowsky Brunoni
    Clinical Research Center, University Hospital, University of Sao Paulo, Brazil
    Contemp Clin Trials 32:90-8. 2011
    ..Due to its profile, tDCS seems to be a safe and affordable approach...
  38. pmc Sertraline exposure leads to small left heart syndrome in adult mice
    Sarah E Haskell
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Pediatr Res 73:286-93. 2013
    b>Sertraline, a selective serotonin reuptake inhibitor (SSRI), is the most commonly prescribed therapy for maternal depression...
  39. ncbi Chronic modulation of serotonergic neurotransmission with sertraline attenuates the loudness dependence of the auditory evoked potential in healthy participants
    Julian G Simmons
    Orygen Youth Health Research Centre, Locked Bag 10, Parkville, Victoria 3052, Australia
    Psychopharmacology (Berl) 217:101-10. 2011
    ..However, acute manipulations of the serotonergic system in humans and animals have yielded inconsistent findings...
  40. pmc Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise
    Thibault Renoir
    Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 165:1375-89. 2012
    ..Depression is the most common psychiatric disorder in Huntington's disease (HD) patients. Women are more prone to develop depression and such susceptibility might be related to 5-hydroxytryptaminergic (serotonergic) dysregulation...
  41. ncbi The antidepressant sertraline downregulates Akt and has activity against melanoma cells
    Kalpana K Reddy
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
    Pigment Cell Melanoma Res 21:451-6. 2008
    ..The antidepressant sertraline was found to be a potent cytotoxic agent against A375 human melanoma...
  42. ncbi Effect of sertraline on symptoms and survival in patients with advanced cancer, but without major depression: a placebo-controlled double-blind randomised trial
    Martin R Stockler
    NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia
    Lancet Oncol 8:603-12. 2007
    ..We aimed to identify the effects of an established antidepressant on these symptoms and survival in patients with advanced cancer who did not have major depression as assessed by clinicians...
  43. pmc Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms
    Alison Oliveto
    University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Addiction 107:131-41. 2012
    Whether the selective serotonin re-uptake inhibitor sertraline at 200 mg/day delays relapse in recently abstinent cocaine-dependent individuals.
  44. ncbi Sertraline promotes hippocampus-derived neural stem cells differentiating into neurons but not glia and attenuates LPS-induced cellular damage
    Zheng Wu Peng
    Department of Psychosomatic Medicine, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Prog Neuropsychopharmacol Biol Psychiatry 36:183-8. 2012
    b>Sertraline is one of the most commonly used antidepressants in clinic...
  45. pmc Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect
    Hans Rollema
    Department Neuroscience, Pfizer Global Research and Development, Groton, CT 06340, USA
    Eur J Pharmacol 605:114-6. 2009
    ..dose significantly enhanced the effects of moderately active doses of the selective serotonin reuptake inhibitor sertraline. These findings are consistent with the notion that reducing alpha4beta2 nicotinic acetylcholine receptor ..
  46. pmc Effects of coping skills training and sertraline in patients with non-cardiac chest pain: a randomized controlled study
    Francis J Keefe
    Duke University Medical Center, Durham, NC 27705, USA
    Pain 152:730-41. 2011
    ..This randomized clinical trial examined the separate and combined effects of CST and antidepressant medication (sertraline) in participants with non-cardiac chest pain...
  47. ncbi Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial
    K Brady
    Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    JAMA 283:1837-44. 2000
    ..Despite the high prevalence, chronicity, and associated comorbidity of posttraumatic stress disorder (PTSD) in the community, few placebo-controlled studies have evaluated the efficacy of pharmacotherapy for this disorder...
  48. pmc The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast
    Meredith M Rainey
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Genetics 185:1221-33. 2010
    Numerous studies have shown that the clinical antidepressant sertraline (Zoloft) is biologically active in model systems, including fungi, which do not express its putative protein target, the serotonin/5-HT transporter, thus ..
  49. ncbi An 8-week multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression
    Lon S Schneider
    Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, and the Leonard Davis School of Gerontology, University of SouthernCalifornia, Los Angeles, CA 90033, USA
    Am J Psychiatry 160:1277-85. 2003
    There have been few placebo-controlled trials of selective serotonin reuptake inhibitors for depressed elderly patients. This placebo-controlled study of sertraline was designed to confirm the results of non-placebo-controlled trials.
  50. pmc Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety
    John T Walkup
    Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21287, USA
    N Engl J Med 359:2753-66. 2008
    ..Although cognitive behavioral therapy and selective serotonin-reuptake inhibitors have shown efficacy in treating these disorders, little is known about their relative or combined efficacy...
  51. ncbi Effect of single-dose sertraline on the hypothalamus-pituitary-adrenal system, autonomic nervous system, and platelet function
    Thorben Ahrens
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Clin Psychopharmacol 27:602-6. 2007
    ..We compared the reaction of these systems to physical stress with single-dose SSRI treatment (100 mg) with that of placebo treatment...
  52. ncbi Block of volume-regulated anion channels by selective serotonin reuptake inhibitors
    C Maertens
    KU Leuven, Laboratorium voor Fysiologie, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Naunyn Schmiedebergs Arch Pharmacol 366:158-65. 2002
    We have used the whole-cell patch clamp technique to study the effects of the commonly used antidepressants sertraline, paroxetine, citalopram and fluvoxamine on the volume-regulated anion channel (VRAC) in endothelial cells...
  53. ncbi Evaluation of the potential anti-cancer activity of the antidepressant sertraline in human colon cancer cell lines and in colorectal cancer-xenografted mice
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsentein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University and Campus Rabin, Petah Tikva 49100, Israel
    Int J Oncol 33:277-86. 2008
    ..The SSRIs, paroxetine and sertraline, induced a dose-dependent inhibition of cell viability and proliferation in the two cell lines (IC50 8-15 micro ..
  54. ncbi Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635
    G Bagdy
    Department of Neurology, Semmelweis University, Hungary
    Int J Neuropsychopharmacol 4:399-408. 2001
    ..Fluoxetine (2.5-10 mg/kg, i.p.), sertraline (15 mg/kg, i.p.) and m-CPP (0.5-2.0 mg/kg, i.p...
  55. ncbi Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial
    Rena Cooper-Kazaz
    Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Arch Gen Psychiatry 64:679-88. 2007
    ..Antidepressant treatments that achieve a higher remission rate than those currently available are urgently needed. The thyroid hormone triiodothyronine may potentiate antidepressant effects...
  56. ncbi Sertraline to improve arousal and alertness in severe traumatic brain injury secondary to motor vehicle crashes
    J M Meythaler
    University of Alabama at Birmingham Model Traumatic Brain Injury System Spain Rehabilitation Center, Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine, Birmingham, AL, USA
    Brain Inj 15:321-31. 2001
    To establish whether or not the serotonin reuptake inhibitor (SSRI) sertraline can improve arousal and alertness of patients with traumatic brain injury (TBI) and associated diffuse axonal injury (DAI)...
  57. ncbi Neuroimmune and cortisol changes in selective serotonin reuptake inhibitor and placebo treatment of chronic posttraumatic stress disorder
    Phebe Tucker
    Department of Psychiatry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Biol Psychiatry 56:121-8. 2004
    ....
  58. ncbi Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 59:821-8. 2006
    ..Previous studies used chronic SSRI administration that may down-regulate 5-HTT and used the cerebellum as reference region despite measurable 5-HTT. We examine the reference region and occupancy after acute sertraline dosing.
  59. ncbi Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain
    Puneet Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 33:100-8. 2009
    ..The present study evaluated the possible role of sertraline on the 3-nitropropionic acid induced behavioral, biochemical, and mitochondrial alterations in discrete areas of ..
  60. ncbi Venlafaxine extended release in posttraumatic stress disorder: a sertraline- and placebo-controlled study
    Jonathan Davidson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychopharmacol 26:259-67. 2006
    This 12-week, double-blind, multicenter trial evaluated the efficacy of venlafaxine extended release (ER), sertraline, and placebo in adult outpatients (N = 538) with a primary diagnosis of posttraumatic stress disorder (PTSD), as defined ..
  61. ncbi Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis
    D C Mohr
    Department of Neurology, University of California, San Fancisco, USA
    J Consult Clin Psychol 69:942-9. 2001
    ..and the antidepressant sertraline. Significant reductions were seen from pre- to posttreatment in all measures of depression...
  62. pmc Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy
    Levent Sutcigil
    Department of Psychiatry, Gulhane Military Medical Academy, 06018 Ankara, Turkey
    Clin Dev Immunol 2007:76396. 2007
    ..role of IL-2, IL-4, IL-12, TNF-alpha, TGF-beta1, and MCP-1 in major depression and to investigate the effects of sertraline therapy...
  63. ncbi Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline
    R M Post
    Department of Health and Human Services, National Institute of Mental Health, Bethesda, Maryland, USA
    Br J Psychiatry 189:124-31. 2006
    ..Few studies have examined the relative risks of switching into hypomania or mania associated with second-generation antidepressant drugs in bipolar depression...
  64. ncbi A pilot randomized controlled trial of combined trauma-focused CBT and sertraline for childhood PTSD symptoms
    Judith A Cohen
    Drexel University College of Medicine, Allegheny General Hospital, Department of Psychiatry, Pittsburgh, USA
    J Am Acad Child Adolesc Psychiatry 46:811-9. 2007
    To examine the potential benefits of adding a selective serotonin reuptake inhibitor, sertraline, versus placebo, to trauma-focused cognitive-behavioral therapy (TF-CBT) for improving posttraumatic stress disorder and related ..
  65. ncbi Onset of major depression associated with acute coronary syndromes: relationship of onset, major depressive disorder history, and episode severity to sertraline benefit
    Alexander H Glassman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Gen Psychiatry 63:283-8. 2006
    ..The Sertraline Antidepressant Heart Attack Trial (SADHART) tested the safety and efficacy of a selective serotonin reuptake ..
  66. ncbi The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorder
    L Kathryn Durham
    Biostatistical Applications, Pfizer Global Research and Development, 1 Eastern Point Road, Groton, CT 063401, USA
    Psychopharmacology (Berl) 174:525-9. 2004
    ..We hypothesized that a similar effect in response time to sertraline would be observed and that no effect on response time would be seen in a placebo arm.
  67. ncbi Sertraline treatment of pathological gambling: a pilot study
    Jeronimo Saiz-Ruiz
    Department of Psychiatry, Hospital Ramon y Cajal, Universidad de Alcala, Madrid, Spain
    J Clin Psychiatry 66:28-33. 2005
    ..The purpose of this study was to evaluate the efficacy of sertraline in the treatment of pathological gambling.
  68. ncbi Treatment benefit and the risk of suicidality in multicenter, randomized, controlled trials of sertraline in children and adolescents
    John S March
    Department of Psychiatry and Behavioral Sciences, Duke Child and Family Study Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Child Adolesc Psychopharmacol 16:91-102. 2006
    The aim of this study was to examine the balance between the benefits of treatment and the risk of suicidality in children and adolescents in multicenter, randomized, controlled trials of sertraline versus placebo.
  69. ncbi Treatment of pharmacotherapy-refractory posttraumatic stress disorder among Cambodian refugees: a pilot study of combination treatment with cognitive-behavior therapy vs sertraline alone
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman St, Boston, MA 02114, USA
    Behav Res Ther 41:1271-6. 2003
    ..selected a sample of pharmacotherapy-refractory individuals to test the efficacy of combination treatment with sertraline and cognitive-behavior therapy (CBT) for treating PTSD...
  70. ncbi Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder
    Joseph Zohar
    Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
    J Clin Psychopharmacol 22:190-5. 2002
    The efficacy of sertraline in the treatment of civilian posttraumatic stress disorder (PTSD) has been established by two large placebo-controlled trials...
  71. ncbi Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder
    J R Davidson
    Anxiety and Traumatic Stress Program, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 58:485-92. 2001
    ..DSM-III-R diagnosis of moderate-to-severe PTSD were randomized to 12 weeks of double-blind treatment with either sertraline (N = 100) in flexible daily doses in the range of 50 to 200 mg or placebo (N = 108)...
  72. ncbi Comparative study of fluoxetine, sibutramine, sertraline and dexfenfluramine on the morphology of serotonergic nerve terminals using serotonin immunohistochemistry
    M Kalia
    Department of Biochemistry, Molecular Pharmacology and Anesthesiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Brain Res 858:92-105. 2000
    We compared the effects of treatment with high doses of fluoxetine, sibutramine, sertraline, and dexfenfluramine for 4 days on brain serotonergic nerve terminals in rats...
  73. ncbi Antidepressant effect on connectivity of the mood-regulating circuit: an FMRI study
    Amit Anand
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuropsychopharmacology 30:1334-44. 2005
    ..This study investigated the effects of sertraline, a selective serotonin reuptake inhibitor antidepressant, on corticolimbic connectivity, using functional ..
  74. pmc Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia
    K Luan Phan
    Department of Psychiatry, University of Illinois at Chicago, and Mental Health Service Line, Jesse Brown VA Medical Center, Chicago, IL 60608, USA
    Biol Psychiatry 73:329-36. 2013
    ..Although selective serotonin reuptake inhibitor (SSRI) treatment is known to be an effective treatment, little is known about the mechanism through which these agents exert their anxiolytic effects at a brain level in gSP...
  75. ncbi Nicotine reverses anhedonic-like response and cognitive impairment in the rat chronic mild stress model of depression: comparison with sertraline
    Jesper T Andreasen
    Centre for Psychiatric Research, Aarhus University Hospital, Aarhus, Denmark
    J Psychopharmacol 25:1134-41. 2011
    ..Here, we examine the effect of chronic treatment of nicotine (0.4 mg/kg/day) and sertraline (5 mg/kg/day) on CMS-induced anhedonic-like behaviour and impairment in the SAB test...
  76. ncbi Effects of sertraline on behavioral alterations caused by environmental enrichment and social isolation
    Engin Yildirim
    Eskisehir Osmangazi University, Faculty of Medicine, Department of Pharmacology, 26480 Eskisehir, Turkey
    Pharmacol Biochem Behav 101:278-87. 2012
    ..In this study, the effects of sertraline, a selective serotonin (5-HT) reuptake inhibitor, on anxiety- and depression-like behaviors were investigated in ..
  77. ncbi The impact of ziprasidone in combination with sertraline on visually-evoked event-related potentials in depressed patients with psychotic features
    O Moeller
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:1440-3. 2007
    ..The objective of this study was to examine the effects of a combination therapy with ziprasidone and sertraline on ERP in major depression with psychotic features.
  78. ncbi Preliminary comparison of sertraline levels in postbariatric surgery patients versus matched nonsurgical cohort
    James L Roerig
    University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA
    Surg Obes Relat Dis 8:62-6. 2012
    ..The purpose of the present pilot trial was to determine to what extent RYGB alters the area under the plasma concentration/time curve (AUC(0-10.5)) of the antidepressant, sertraline at a community research center.
  79. pmc Strategic use of new generation antidepressants for depression: SUN(^_^)D study protocol
    Toshi A Furukawa
    Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine School of Public Health, Yoshida konoe cho, Sakyo ku, Japan
    Trials 12:116. 2011
    ..Starting with these findings, this proposed trial aims to establish the optimum 1st line and 2nd line antidepressant treatment strategy among adult patients with a non-psychotic unipolar major depressive episode...
  80. ncbi Adjunctive low-dose aripiprazole with standard-dose sertraline in treating fresh major depressive disorder: a randomized, double-blind, controlled study
    Chien Ho Lin
    Department of Psychiatry, Chi Mei Medical Center, Tainan City, Taiwan
    J Clin Psychopharmacol 31:563-8. 2011
    ..This clinical trial evaluated the efficacy and safety of low-dose aripiprazole combined with regular-dose sertraline for acute major depressive episode in non-treatment-resistant depression outpatients.
  81. ncbi Affective and anxiety comorbidity in post-traumatic stress disorder treatment trials of sertraline
    Kathleen T Brady
    Medical University of South Carolina, Charleston 29425, USA
    Compr Psychiatry 44:360-9. 2003
    ..The current study evaluated the efficacy and tolerability of sertraline in a subgroup of PTSD patients suffering from anxiety or depression comorbidity...
  82. ncbi Clinical trial of sertraline in the treatment of night eating syndrome
    John P O'Reardon
    Department of Psychiatry, Weight and Eating Disorders Program, University of Pennsylvania, Philadelphia, 19104, USA
    Int J Eat Disord 35:16-26. 2004
    To test the efficacy of sertraline in the treatment of night eating syndrome.
  83. ncbi Symptom improvement in co-occurring PTSD and alcohol dependence
    Sudie E Back
    Medical University of South Carolina, Department of Psychiatry, Charleston, South Carolina 29425, USA
    J Nerv Ment Dis 194:690-6. 2006
    ....
  84. ncbi Does randomized evidence support sertraline as first-line antidepressant for adults with acute major depression? A systematic review and meta-analysis
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico G B Rossi, Piazzale L A Scuro, 10, 37134 Verona, Italy
    J Clin Psychiatry 69:1732-42. 2008
    Preliminary evidence suggested that sertraline might be slightly superior to other antidepressant medications in terms of efficacy...
  85. ncbi Comparison of antinociceptive and antidiabetic effects of sertraline and amitriptyline on streptozotocin-induced diabetic rats
    Danish Mahmood
    Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
    Hum Exp Toxicol 29:881-6. 2010
    ..The aim of this study is to investigate the antinociceptive effects of sertraline (Ser) and amitriptyline (Ami) in diabetic rats, and additionally monitoring their effects on grip strength, ..
  86. ncbi Posttraumatic stress disorder and quality of life: results across 64 weeks of sertraline treatment
    Mark H Rapaport
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA
    J Clin Psychiatry 63:59-65. 2002
    ..The goal of the current study was to characterize the quality of life (QOL) and functional impairment associated with posttraumatic stress disorder (PTSD) and to report the QOL/functional response over the course of long-term treatment...
  87. ncbi Spotlight on sertraline in the management of major depressive disorder in elderly patients
    Richard B R Muijsers
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    CNS Drugs 16:789-94. 2002
    b>Sertraline is a selective serotonin reuptake inhibitor (SSRI) with well established antidepressant and anxiolytic activity...
  88. ncbi Effects of sertraline treatment on plasma cortisol, prolactin and thyroid hormones in female depressed patients
    Marina Sagud
    University Hospital Center Zagreb, Department of Psychiatry, Zagreb, Croatia
    Neuropsychobiology 45:139-43. 2002
    The aim of the study was to evaluate the effects of 4 and 24 weeks of sertraline treatment (average dose 42.5 mg/day) on plasma hormone levels in 15 female patients with major depression...
  89. ncbi Sertraline and mirtazapine as geriatric antidepressants
    Jonathon Holland
    Department of Medicine for the Elderly, Addenbrooke s Hospital, Hills Road, CB2 0QQ, Cambridge, UK
    Psychiatr Danub 25:S286-90. 2013
    ..Unfortunately these can have significant side-effects in the elderly such as hyponatraemia. Sertraline is one such SSRI commonly used in the geriatric population...
  90. ncbi Gender, aggression and serotonergic function are associated with response to sertraline for behavioral disturbances in Alzheimer's disease
    Krista L Lanctot
    Psychopharmacology Research Program and Geriatric Psychiatry, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, 207s Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Int J Geriatr Psychiatry 17:531-41. 2002
    ..Indications for serotonergic medications in the treatment of behavioral disorders associated with Alzheimer's disease (AD) remain to be established...
  91. ncbi Impact of early administration of sertraline on depressive symptoms in the first year after traumatic brain injury
    Thomas A Novack
    Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama 35249 7330, USA
    J Neurotrauma 26:1921-8. 2009
    The potential for sertraline administered in the first 3 months after moderate to severe traumatic brain injury (TBI) to decrease the incidence of depression in the first year after injury was assessed in a double-blinded randomized ..
  92. ncbi Comparison of blinding effectiveness between sham tDCS and placebo sertraline in a 6-week major depression randomized clinical trial
    Andre Russowsky Brunoni
    Center for Clinical and Epidemiological Research, University Hospital, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil Interdisciplinary Center for Applied Neuromodulation, University Hospital, University of Sao Paulo, Sao Paulo, Brazil Electronic address
    Clin Neurophysiol 125:298-305. 2014
    ..To compare blinding integrity and associated factors for transcranial direct current stimulation (tDCS) vs. placebo-pill, the gold standard blinding method...
  93. ncbi Comparing effects of methylphenidate, sertraline and placebo on neuropsychiatric sequelae in patients with traumatic brain injury
    Hoon Lee
    Department of Psychiatry and Research Institute of Medical Science, Chonnam National University Medical School, Kwangju, Republic of Korea
    Hum Psychopharmacol 20:97-104. 2005
    This study aimed to investigate the effects of methylphenidate and sertraline compared with placebo on various neuropsychiatric sequelae associated with traumatic brain injury (TBI).
  94. pmc Safety and efficacy of sertraline for depression in patients with CHF (SADHART-CHF): a randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 156:437-44. 2008
    b>Sertraline, a selective serotonin-reuptake inhibitor, has demonstrated substantial mood improvement in patients with post myocardial infarction or with unstable angina...
  95. ncbi Drug interactions between linezolid and selective serotonin reuptake inhibitors: case report involving sertraline and review of the literature
    Deidre B Clark
    Department of Pharmacy, Tuscaloosa Veterans Affairs Medical Center, Tuscaloosa, Alabama 35404, USA
    Pharmacotherapy 26:269-76. 2006
    ..woman developed confusion, incoordination, and hypertension after she was given linezolid in addition to sertraline for 5 days. Her symptoms resolved within 4 days of discontinuing linezolid...
  96. ncbi Effects of sertraline on kinematic aspects of hand movements in patients with obsessive-compulsive disorder
    Roland Mergl
    Department of Psychiatry, Laboratory of Clinical Neurophysiology, Ludwig Maximilians Universitat Munchen, Nussbaumstrasse 7, 80336, Munchen, Germany
    Psychopharmacology (Berl) 171:179-85. 2004
    ..Movement disorders such as disturbances of fine motor co-ordination are a frequent phenomenon in patients with obsessive-compulsive disorder (OCD)...
  97. ncbi Estradiol-sertraline synergy in ovariectomized rats
    Stacy L Sell
    Center for Addiction Research, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1031, United States
    Psychoneuroendocrinology 33:1051-60. 2008
    ..E(2)) modulation of the antidepressant effects of a selective serotonin (5-HT) reuptake inhibitor (SSRI; sertraline) and a tricyclic antidepressant (imipramine) as measured by the forced swim test (FST) followed by assessment of ..
  98. ncbi Global gene expression in larval zebrafish (Danio rerio) exposed to selective serotonin reuptake inhibitors (fluoxetine and sertraline) reveals unique expression profiles and potential biomarkers of exposure
    June Woo Park
    Center for Environmental Biotechnology, University of Tennessee, 676 Dabney Hall, Knoxville, TN 37996, USA
    Environ Pollut 167:163-70. 2012
    ..zebrafish (Danio rerio) were exposed (96 h) to selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and changes in transcriptomes analyzed by Affymetrix GeneChip Zebrafish Array were evaluated to enhance ..
  99. ncbi The effect of sertraline add-on to brief dynamic psychotherapy for the treatment of postpartum depression: a randomized, double-blind, placebo-controlled study
    Miki Bloch
    Department of Psychiatry, Tel Aviv Sourasky Medical Center, 6 Weizman Str, Tel Aviv, Israel
    J Clin Psychiatry 73:235-41. 2012
    ..We hypothesized that psychotherapy and concurrent antidepressant treatment would be more effective than psychotherapy alone in the treatment of postpartum depression...
  100. ncbi Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs
    K L Wisner
    Division of Pediatric Pharmacology and Critical Care, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Psychiatry 155:690-2. 1998
    The authors' goal was to study the serum sertraline levels of breast-feeding mothers and their infants.
  101. ncbi Sertraline to treat hot flashes: a randomized controlled, double-blind, crossover trial in a general population
    Paul R Gordon
    College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Menopause 13:568-75. 2006
    To evaluate the effectiveness of a selective serotonin reuptake inhibitor (SSRI) (sertraline) in decreasing hot flashes in a general population of women.

Research Grants65

  1. CNS Mechanisms of Acute Hypoglycemia-Associate Autonomic Failure
    DIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2012
    ..Finally, we will evaluate the effect of the serotonergic agent sertraline (SERT) on the hypoglycemia CRR in diabetic rats, as we have observed enhanced EPI responding in non-diabetic ..
  2. Rhodiola rosea Therapy of Major Depressive Disorder
    Jun J Mao; Fiscal Year: 2012
    ..For specific aim #1, we will ask: Is R. rosea a safe and effective short-term therapy (vs. sertraline and placebo) for patients with MDD?" To answer this question, patients meeting DSM IV criteria for mild to ..
  3. Vagal Nerve Stimulation &Antidepressants: c-Fos, deltaFosB and TrkB Activation
    Alan Frazer; Fiscal Year: 2012
    ..by the selective noradrenergic reuptake inhibitor, desipramine, and the selective serotonin reuptake inhibitor, sertraline, (2) use the chronic VNS protocol that has the best effect in the FST to measure its effects on c-Fos, [..
  4. Brain Markers of Anxiety Disorders and SSRI Treatment in Children and Adolescents
    Kinh Luan Phan; Fiscal Year: 2013
    ..In the context of a randomized, placebo-controlled clinical trial of the SSRI sertraline, a widely-used first-line treatment with a variable response rate (pooled estimate of 63%;range: 55-91%) based ..
  5. Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis
    David R Boulware; Fiscal Year: 2013
    ..neurological, functional, and neurocognitive status in a randomized clinical trial to determine if adjunctive sertraline has antifungal activity and neurocognitive benefit...
  6. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..a) the tricyclic (amitriptyline, imipramine), (b) the selective serotonin uptake inhibitors (fluoxetine, sertraline) and (c) bupropion on secretion of histamine, IL-1, IL-6, IL-8, IL-13, TNF, tryptase and VEGF from normal human ..
  7. Randomized trial of sertraline treatment of depression in Chronic Kidney Disease
    SUSAN HEDAYATI; Fiscal Year: 2013
    ..The Sertraline AntiDepressant Heart Attack Randomized Trial showed benefit of serotonin-selective reuptake inhibitor (SSRI) ..
  8. Randomized trial of sertraline treatment of depression in Chronic Kidney Disease
    SUSAN HEDAYATI; Fiscal Year: 2012
    ..The Sertraline AntiDepressant Heart Attack Randomized Trial showed benefit of serotonin-selective reuptake inhibitor (SSRI) ..
  9. Neuro-Genetic Markers of SSRI Treatment Response in Social Anxiety Disorder
    K Luan Phan; Fiscal Year: 2010
    ..In the context of an open-label clinical trial of sertraline, this study proposes to perform pre- and post-treatment fMRI of amygdala reactivity to harsh/negative face ..
  10. 4/4-Sustaining Remission of Psychotic Depression
    Alastair J Flint; Fiscal Year: 2013
    ..The combination of sertraline and olanzapine was significantly more efficacious than olanzapine combined with placebo...
  11. 2/4-Sustaining Remission of Psychotic Depression
    Anthony J Rothschild; Fiscal Year: 2013
    ..The combination of sertraline and olanzapine was significantly more efficacious than olanzapine combined with placebo...
  12. 1/4-Sustaining Remission of Psychotic Depression
    Barnett Meyers; Fiscal Year: 2013
    ..The combination of sertraline and olanzapine was significantly more efficacious than olanzapine combined with placebo...
  13. 3/4-Sustaining Remission of Psychotic Depression
    Ellen M Whyte; Fiscal Year: 2013
    ..The combination of sertraline and olanzapine was significantly more efficacious than olanzapine combined with placebo...
  14. Structural and Mechanistic Characterization of Neurotransmitter Reuptake Inhibiti
    DANENG WANG; Fiscal Year: 2012
    ..by various drugs and therefore are the primary targets for: antidepressants such as fluoxetine (Prozac), sertraline (Zoloft), methylphenidate (Ritalin) -a prescription drug commonly used to treat attention-deficit hyperactivity ..
  15. Monoamine Transporter Regulation and Antidepressant Activity
    JAMES O DONNELL; Fiscal Year: 2009
    ..PKC or PP1/2A inhibition alters the neurochemical and behavioral effects of the NRI desipramine and the SRI sertraline. The completion of the proposed research will elucidate the role of altered NET and SERT expression and function ..
  16. Placebo Controlled Trial of Sertraline and IPT for Postpartum Depression
    Scott P Stuart; Fiscal Year: 2012
    ..The aim of this project is to compare the efficacy of three treatment conditions: 1) Pharmacotherapy alone (Sertraline + Clinical Management);2) IPT alone;and 3) Placebo (Pill Placebo + Clinical Management)...
  17. Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury
    RICARDO ESTEBAN JORGE; Fiscal Year: 2012
    ..In this study, we will examine the efficacy of sertraline to prevent the onset of mood and anxiety disorders during the first six months after TBI...
  18. Placebo Controlled Trial of Sertaline and IPT for Postpartum Depression
    Caron Zlotnick; Fiscal Year: 2012
    ..The aim of this project is to compare the efficacy of three treatment conditions: 1) Pharmacotherapy alone (Sertraline + Clinical Management);2) IPT alone;and 3) Placebo (Pill Placebo + Clinical Management)...
  19. Novel Approaches to Alcoholism Pharmacotherapy and Risk
    HENRY RICHARD KRANZLER; Fiscal Year: 2012
    ..drinkers, 2) complete data collection, analysis, and report preparation for a placebo-controlled study of sertraline for alcoholism subtypes, and 3) conduct a placebo-controlled trial of topiramate for problem drinkers...
  20. Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial
    Franklin R Schneier; Fiscal Year: 2012
    ..In this study, 60 patients with civilian PTSD will be randomized to 24 weeks of double-blind treatment with sertraline + mirtazapine versus sertraline + placebo...
  21. 3/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)
    GOLDA SUSAN GINSBURG; Fiscal Year: 2013
    ..e., CBT, sertraline [SRT], pill placebo, or combined CBT + SRT). CAMS succeeded in randomizing 488 children/adolescents...
  22. 6/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)
    John C Piacentini; Fiscal Year: 2013
    ..e., CBT, sertraline [SRT], pill placebo, or combined CBT + SRT). CAMS succeeded in randomizing 488 children/adolescents...
  23. CARDIAC RISK MARKERS AND UNREMITTING DEPRESSION IN ACUTE CORONARY SYNDROME
    Robert M Carney; Fiscal Year: 2012
    ..gt;50 percent on the BDI-II depression questionnaire by 3 months will continue in CBT but will also be given sertraline at an initial dosage of 50 mg/day...
  24. Effects of Maintenance Treatment with Olanzapine vs. Placebo on Brain Structure
    ARISTOTLE NICHOLAS VOINESKOS; Fiscal Year: 2013
    ..provided by STOP-PD II: 152 subjects who achieve remission after 12 weeks of acute open treatment with sertraline plus olanzapine and remain stable over the following 8 weeks will be randomized to continuing olanzapine vs...
  25. 4/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)
    Philip C Kendall; Fiscal Year: 2013
    ..e., CBT, sertraline [SRT], pill placebo, or combined CBT + SRT). CAMS succeeded in randomizing 488 children/adolescents...
  26. 1/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)
    Anne Marie Albano; Fiscal Year: 2013
    ..e., CBT, sertraline [SRT], pill placebo, or combined CBT + SRT). CAMS succeeded in randomizing 488 children/adolescents...
  27. 1/3-Multi-Site - Omega-3 for Co-Morbid Depression &HF Treatment (OCEAN)
    CHRISTOPHER M O'CONNOR; Fiscal Year: 2013
    ..antidepressants on the market, are considered a safe type of antidepressant for patients with cardiac diseases, sertraline failed to show superiority over placebo in reducing depression or cardiac outcomes in the recently completed, ..
  28. 2/3-Multi-Site - Omega-3 for Co-Morbid Depression &HF Treatment (OCEAN)
    David J Whellan; Fiscal Year: 2013
    ..antidepressants on the market, are considered a safe type of antidepressant for patients with cardiac diseases, sertraline failed to show superiority over placebo in reducing depression or cardiac outcomes in the recently completed, ..
  29. 3/3-Multi-Site - Omega-3 for Co-Morbid Depression &HF Treatment (OCEAN)
    Kirkwood F Adams; Fiscal Year: 2013
    ..antidepressants on the market, are considered a safe type of antidepressant for patients with cardiac diseases, sertraline failed to show superiority over placebo in reducing depression or cardiac outcomes in the recently completed, ..
  30. 1/2-Optimizing PTSD Treatments
    Norah C Feeny; Fiscal Year: 2013
    ..In the choice condition, patients will choose between prolonged exposure (PE) and prolonged exposure plus sertraline (PE + SER)...
  31. 2/2-Optimizing PTSD Treatments
    Lori A Zoellner; Fiscal Year: 2013
    ..In the choice condition, patients will choose between prolonged exposure (PE) and prolonged exposure plus sertraline (PE + SER)...
  32. Improved Dehydration Process for Pharmaceutical Synthesis II
    Ashok B Shenvi; Fiscal Year: 2012
    ..any organic-water environment for water separation in the synthesis of products such as sildenafil, celecoxib, sertraline, and aprepitant...
  33. Bipolar II Depression: Lithium, SSRI, or the Combination
    Trisha Suppes; Fiscal Year: 2010
    ..We propose a randomized, double-blind 16-week acute clinical trial comparing the efficacy and safety of sertraline monotherapy v. lithium monotherapy v...
  34. Bipolar II Depression: Lithium, SSRI or the Combination
    Susan L McElroy; Fiscal Year: 2010
    ..We propose a randomized, double-blind 16-week acute clinical trial comparing the efficacy and safety of sertraline monotherapy v. lithium monotherapy v...
  35. Effects of Sertraline on Brain Connectivity in Adolescents with OCD
    GAIL BERNSTEIN BERNSTEIN; Fiscal Year: 2013
    ..OCD participants will receive 12 weeks of sertraline, a selective serotonin reuptake inhibitor (SSRI), to treat OCD symptoms...
  36. DIADS-3: An RCT of venlafaxine for depression in AD
    Paul B Rosenberg; Fiscal Year: 2013
    ..AD (dAD), and we have recently published results from a hypothesis-testing randomized controlled trial (RCT) of sertraline for dAD which showed no drug effect. Thus, there is a great need for development of new treatments for dAD...
  37. COCAINE PHARMACOTHERAPIES FOR COMORBID POPULATIONS
    Thomas Kosten; Fiscal Year: 2003
    ..Trials 1 and 2 are "Bupropion & sertraline for depression and cocaine dependence" including 60 patients each in randomized, placebo controlled 12 week ..
  38. A Pharmacokinetic Comparison of Sertraline Before and After Bariatric Surgery
    KRISTINE JAYNE STEFFEN; Fiscal Year: 2013
    ..Thus, a prospective, longitudinal trial is proposed to investigate the pharmacokinetic parameters of sertraline preoperatively and at three and 12 months following RYGBP...
  39. Cognitive processing therapy for PTSD with co-morbid mild traumatic brain injury
    KALOYAN STEFANOV TANEV; Fiscal Year: 2013
    ..Subjects'PTSD symptoms will be assessed at baseline, at regular intervals during CPT and sertraline treatment, and 6 months after completing treatment...
  40. Frontal hypo perfusion effects on antidepressant outcomes in geriatric depression
    Warren D Taylor; Fiscal Year: 2013
    ..complete clinical, cognitive, and MRI assessments before and after a 12-week open-label antidepressant trial of sertraline. Regional cerebral perfusion will be assessed using arterial spin labeling (ASL) at a) rest, b) during an ..
  41. Prolonged Exposure vs Sertraline in the Treatment of Inhibitory Deficits in PTSD
    AILEEN MARIE ECHIVERRI; Fiscal Year: 2010
    ..women with chronic PTSD who receive either 10 weeks of prolonged exposure, a cognitive behavioral therapy, or sertraline, a serotonergic medication...
  42. M-CPP PET Scanning of Alcoholism:Effects of Sertraline
    Monte Buchsbaum; Fiscal Year: 2006
    ..One study demonstrated a significant effect of the SSRI sertraline in late-onset (type A) alcoholics, while the other demonstrated efficacy of the 5-HT3-antagonist ondansetron in ..
  43. R21 Project: St. John's Wort vs. Placebo in OCD
    Kenneth Kobak; Fiscal Year: 2003
    ..g., drop-out rates in the multi-center trials of fluoxetine, fluvoxamine, sertraline, and paroxetine were 23%, 24%, 27%, and 20% respectively. There has been considerable worldwide interest in St...
  44. Depression in Alzheimer's Disease Study-2(DIADS-2)
    Daniel Weintraub; Fiscal Year: 2007
    ..study is to determine whether individuals with dAD respond to antidepressant treatment using the medication sertraline in a 12-week randomized, controlled, double blind trial...
  45. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Anton Porsteinsson; Fiscal Year: 2007
    ..study is to determine whether individuals with dAD respond to antidepressant treatment using the medication sertraline in a 12-week randomized, controlled, double blind trial...
  46. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Constantine Lyketsos; Fiscal Year: 2007
    ..study is to determine whether individuals with dAD respond to antidepressant treatment using the medication sertraline in a 12-week randomized, controlled, double blind trial...
  47. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Lon Schneider; Fiscal Year: 2007
    ..study is to determine whether individuals with dAD respond to antidepressant treatment using the medication sertraline in a 12-week randomized, controlled, double blind trial...
  48. THYROID AXIS IN MAJOR DEPRESSION
    Philip Ninan; Fiscal Year: 2002
    ..application proposes to systematically examine the value of supplemental triiodothyronine (T3, Cytomel) with sertraline, a selective serotonin reuptake inhibitor (SSRI) in the treatment of MDD...
  49. SERTRALINE AND COGNITIVE THERAPY IN DEPRESSED ALCOHOLICS
    Darlene Moak; Fiscal Year: 1999
    ..In a pilot study of outpatient depressed alcoholics, the SSRI, sertraline, demonstrated a beneficial effect on both depressive symptoms and alcohol consumption...
  50. ANXIETY, DEPRESSION, AND NONCARDIAC CHEST PAIN
    Francis Keefe; Fiscal Year: 2005
    ..The proposed study seeks to determine whether the effects of CST can be enhanced by combing it with Sertraline-a psychotropic medication that we have recently found in preliminary research can significantly decrease pain in ..
  51. Depressoin in Alzheimer's Disease Study-2 (DIADS-2)
    Jacobo Mintzer; Fiscal Year: 2007
    ..study is to determine whether individuals with dAD respond to antidepressant treatment using the medication sertraline in a 12-week randomized, controlled, double blind trial...
  52. At-Home Prescription Drug Disposal System
    BADAWI DWEIK; Fiscal Year: 2013
    ..5. Preliminary Design for Phase II Prototype. Focus on designing device prototype for Phase II and product cost analyses to demonstrate feasibility of proposed deactivation device for Phase II scale-up. ..
  53. PREVENTING DEPRESSION RECURRENCE IN DIABETES
    Patrick Lustman; Fiscal Year: 2002
    ..In the open-label phase of the study, 262 depressed NIDDM patients will be treated with sertraline; 156 of these patients are expected to achieve recovery from depression and be assigned randomly to continued ..
  54. TREATMENT OF PEDIATRIC OBSESSIVE COMPULSIVE DISORDER
    John March; Fiscal Year: 2001
    ..the degree and durability of improvement obtained across six treatment conditions: 3 active treatments, sertraline alone (SER), OCD-specific cognitive behavior therapy (CUT), both SER and CUT (SER + CUT), and 3 control ..
  55. Use of Chronoamperometry to Measure Extracellular 5 HT
    Alan Frazer; Fiscal Year: 2005
    ..Time course studies will correlate the time-dependent sertraline-induced changes in SERT density (as measured by quantitative autoradiography) with changes in the ..
  56. SEROTONIN RECEPTOR LIGANDS FOR SPECT IMAGING
    HANK KUNG; Fiscal Year: 2001
    ..commonly prescribed antidepressants, selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, sertraline and paroxetine, modulate 5-HT neurotransmission by blocking the serotonin transporters (SERT)...
  57. SEROTONIN RECEPTOR LIGANDS FOR SPECT IMAGING
    HANK KUNG; Fiscal Year: 2004
    ..commonly prescribed antidepressants, selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, sertraline and paroxetine, modulate 5-HT neurotransmission by blocking the serotonin transporters (SERT)...
  58. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    Graham Emslie; Fiscal Year: 2006
    ..e., fluoxetine, citalopram, escitalopram, sertraline)...
  59. Treatment of Resistant Depression in Adolescents 2
    Gregory Clarke; Fiscal Year: 2006
    ..e., fluoxetine, citalopram, escitalopram, sertraline)...
  60. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    Martin Keller; Fiscal Year: 2006
    ..e., fluoxetine, citalopram, escitalopram, sertraline)...
  61. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    Joan Asarnow; Fiscal Year: 2006
    ..e., fluoxetine, citalopram, escitalopram, sertraline)...
  62. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    David Brent; Fiscal Year: 2006
    ..e., fluoxetine, citalopram, escitalopram, sertraline)...
  63. EFFECTS OF DEPRESSION TREATMENT ON PLATELET ACTIVATION
    LELLAND TOLBERT; Fiscal Year: 2002
    ..in clinical depression, and that pharmacologic treatment with the selective serotonin reuptake inhibitor sertraline attenuates this increase...