Summary: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. pmc An olfactory subsystem that mediates high-sensitivity detection of volatile amines
    Rodrigo Pacifico
    Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA
    Cell Rep 2:76-88. 2012
  2. ncbi Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products
    Oded Kleifeld
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Biotechnol 28:281-8. 2010
  3. pmc Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines
    Robert J Turesky
    Division of Environmental Health Sciences, Wadsworth Center, Albany, New York 12201, United States
    Chem Res Toxicol 24:1169-214. 2011
  4. pmc Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia
    Hansong Wang
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Carcinogenesis 32:203-9. 2011
  5. ncbi Outcome reporting in industry-sponsored trials of gabapentin for off-label use
    S Swaroop Vedula
    Center for Clinical Trials, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    N Engl J Med 361:1963-71. 2009
  6. ncbi Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture
    Christopher K Savile
    Codexis, Incorporated, 200 Penobscot Drive, Redwood City, CA 94063, USA
    Science 329:305-9. 2010
  7. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
  8. ncbi Review of current guidelines on the care of postherpetic neuralgia
    Charles E Argoff
    Albany Medical College, Albany, NY 12208, USA
    Postgrad Med 123:134-42. 2011
  9. pmc Ultrasensitive detection of amines by a trace amine-associated receptor
    Jingji Zhang
    Department of Neurobiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 33:3228-39. 2013
  10. ncbi Process considerations for the asymmetric synthesis of chiral amines using transaminases
    Pär Tufvesson
    Department of Chemical and Biochemical Engineering, Technical University of Denmark, Søltofts Plads, DK 2800 Lyngby, Denmark
    Biotechnol Bioeng 108:1479-93. 2011

Detail Information

Publications373 found, 100 shown here

  1. pmc An olfactory subsystem that mediates high-sensitivity detection of volatile amines
    Rodrigo Pacifico
    Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA
    Cell Rep 2:76-88. 2012
    ..We also show that the dorsal TAAR glomeruli are selectively activated by amines at low concentrations...
  2. ncbi Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products
    Oded Kleifeld
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Biotechnol 28:281-8. 2010
  3. pmc Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines
    Robert J Turesky
    Division of Environmental Health Sciences, Wadsworth Center, Albany, New York 12201, United States
    Chem Res Toxicol 24:1169-214. 2011
    Aromatic amines and heterocyclic aromatic amines (HAAs) are structurally related classes of carcinogens that are formed during the combustion of tobacco or during the high-temperature cooking of meats...
  4. pmc Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia
    Hansong Wang
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Carcinogenesis 32:203-9. 2011 implicates chemical carcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HAAs) as contributing to the development of colorectal cancer (CRC)...
  5. ncbi Outcome reporting in industry-sponsored trials of gabapentin for off-label use
    S Swaroop Vedula
    Center for Clinical Trials, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    N Engl J Med 361:1963-71. 2009
    ..There is good evidence of selective outcome reporting in published reports of randomized trials...
  6. ncbi Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture
    Christopher K Savile
    Codexis, Incorporated, 200 Penobscot Drive, Redwood City, CA 94063, USA
    Science 329:305-9. 2010
    ..The resultant biocatalysts showed broad applicability toward the synthesis of chiral amines that previously were accessible only via resolution...
  7. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
    ..Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies...
  8. ncbi Review of current guidelines on the care of postherpetic neuralgia
    Charles E Argoff
    Albany Medical College, Albany, NY 12208, USA
    Postgrad Med 123:134-42. 2011
  9. pmc Ultrasensitive detection of amines by a trace amine-associated receptor
    Jingji Zhang
    Department of Neurobiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 33:3228-39. 2013 that olfactory sensory neurons that express a subset of the TAAR repertoire are preferentially responsive to amines. In addition, neurons expressing specific TAARs, TAAR3 or TAAR4, are highly sensitive and are also broadly tuned-..
  10. ncbi Process considerations for the asymmetric synthesis of chiral amines using transaminases
    Pär Tufvesson
    Department of Chemical and Biochemical Engineering, Technical University of Denmark, Søltofts Plads, DK 2800 Lyngby, Denmark
    Biotechnol Bioeng 108:1479-93. 2011
    ..This article also points to the interaction between the solutions and the need for a process development strategy based on fundamental principles...
  11. ncbi Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study
    Torsten E Gordh
    Multidisciplinary Pain Center, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Pain 138:255-66. 2008
    ..023) and Clinician (p=0.037) Global Impression of Change indicated a better response with gabapentin compared with placebo. Gabapentin was well tolerated. The most common adverse effects were dizziness and tiredness...
  12. pmc Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin
    Jan Hendrich
    Laboratory for Cellular and Molecular Neuroscience, Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:3628-33. 2008
  13. ncbi Aromatic amines and cancer
    P Vineis
    Unit of Cancer Epidemiology, Dipartimento di Scienze Biomediche e Oncologia Umana, Torino, Italy
    Cancer Causes Control 8:346-55. 1997
    Epidemiological evidence on the relation between aromatic amines and cancer risk is reviewed...
  14. ncbi Uptake and translocation mechanisms of cationic amino derivatives functionalized on pristine C60 by lipid membranes: a molecular dynamics simulation study
    Sebastian Kraszewski
    Laboratoire de Nanomédecine, Imagerie et Thérapeuthique, Universite de Franche Comte, Centre Hospitalier Universitaire de Besancon, 25000 Besancon, France
    ACS Nano 5:8571-8. 2011
    ..Therefore, the lipid bilayer appears to be very selective with respect to the amount of amino groups conjugated with C(60)...
  15. pmc Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity
    Aizhi Zhu
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 53:8556-68. 2010
    ..profile around 5, more advanced compounds in the N,N'-(1, 4-phenylenebis(methylene)) dipyrimidin-2-amines series were discovered and shown to possess higher CXCR4 binding potential and specificity than 5...
  16. ncbi Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase
    Y Oda
    Osaka Prefectural Institute of Public Health, Higashinari ku, 537 0025, Osaka, Japan
    Mutat Res 492:81-90. 2001
    ..investigated roles of different forms of cytochrome P450 (P450 or CYP) in the metabolic activation of heterocyclic amines (HCAs) and other procarcinogens to genotoxic metabolite(s) in the newly developed umu tester strains Salmonella ..
  17. ncbi Specific effects of surface amines on polystyrene nanoparticles in their interactions with mesenchymal stem cells
    Xiue Jiang
    Institute of Biophysics, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Biomacromolecules 11:748-53. 2010
    ..The pronounced difference in the internalization behavior of PS and NPS nanoparticles points to specific interactions of the amino groups on the nanoparticle surface with the endocytosis machinery of the cells...
  18. ncbi Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group
    Augusto Caraceni
    Rehabilitation and Palliative Care Unit, National Cancer Institute of Milan, Via Venezian 1, 20133 Milan, Italy
    J Clin Oncol 22:2909-17. 2004
    ..To determine the analgesic effect of the addition of gabapentin to opioids in the management of neuropathic cancer pain...
  19. ncbi The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain
    S Abdi
    Department of Anesthesiology and Critical Care, The Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesth Analg 87:1360-6. 1998
    ..Finally, the site of action of LDC seems to be primarily in the periphery, and that of GBP is exclusively central, whereas that of AMI seems to have both peripheral and central components...
  20. ncbi Trace amine-associated receptors are olfactory receptors in vertebrates
    Stephen D Liberles
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann N Y Acad Sci 1170:168-72. 2009
    ..Ligands for mouse TAARs include a number of volatile amines, several of which are natural constituents of mouse urine, a rich source of rodent social cues...
  21. ncbi Cellular and molecular action of the putative GABA-mimetic, gabapentin
    Y P Maneuf
    Cambridge Biotechnology Ltd, PO Box 230, Cambridge CB2 1XJ, United Kingdom
    Cell Mol Life Sci 60:742-50. 2003
  22. ncbi Gabapentin selectively reduces persistent sodium current in injured type-A dorsal root ganglion neurons
    Rui Hua Yang
    epartment of Occupational and Environmental Health, The Fourth Military Medical University, Xi an 710032, PR China
    Pain 143:48-55. 2009
    ..The results suggest that GBP decreased the amplitude of resonance and abolished the SMPO of A-type DRG neurons through the inhibition of I(NaP), and thus inhibited the SMPO dependent repetitive and bursting firings...
  23. ncbi Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study
    D Garcia-Borreguero
    Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
    Neurology 59:1573-9. 2002
    ..To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS)...
  24. pmc Analysis of bacterial vaginosis-related amines in vaginal fluid by gas chromatography and mass spectrometry
    H Wolrath
    Division of Clinical Microbiology, Department of Health and Environment, Linkopings Universitet, 581 83 Linkoping, Sweden
    J Clin Microbiol 39:4026-31. 2001
    The presence of various amines in vaginal fluid from women with malodorous vaginal discharge has been reported before. The investigations have used several techniques to identify the amines...
  25. pmc Dedicated olfactory neurons mediating attraction behavior to ammonia and amines in Drosophila
    Soohong Min
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 110:E1321-9. 2013
    ..neurons (OSNs) and projection neurons (PNs) in Drosophila melanogaster that are highly specific to ammonia and amines, which act as potent attractants...
  26. ncbi Effect of cooking methods on the formation of heterocyclic aromatic amines in chicken and duck breast
    G Z Liao
    College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, PR China
    Meat Sci 85:149-54. 2010
    Heterocyclic aromatic amines (HAAs), potent mutagens/carcinogens, are pyrolysis formed during the cooking of meat and fish...
  27. ncbi Production of amines in equine cecal contents in an in vitro model of carbohydrate overload
    S R Bailey
    Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK
    J Anim Sci 80:2656-62. 2002
    ..The products of fermentation that trigger acute laminitis are as yet unknown; however, compounds such as amines might play a role due to their potential vasoactive properties...
  28. ncbi Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines
    Beatriz Maestro
    Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Elche, Spain
    FEBS J 274:364-76. 2007
    ..These results may open up the possibility of the development of bicyclic amines as new antimicrobials for use against pneumococcal pathologies.
  29. ncbi Implications and mechanism of action of gabapentin in neuropathic pain
    Ankesh Kukkar
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147002, Punjab, India
    Arch Pharm Res 36:237-51. 2013
    ..It may also act on supra-spinal region to stimulate noradrenaline mediated descending inhibition, which contributes to its anti-hypersensitivity action in neuropathic pain...
  30. pmc Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment
    Eric T Parker
    Geosciences Research Division, Scripps Institution of Oceanography, University of California at San Diego, 8615 Kennel Way, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:5526-31. 2011
    ..A total of 23 amino acids and 4 amines, including 7 organosulfur compounds, were detected in these samples...
  31. ncbi Coating of adenovirus type 5 with polymers containing quaternary amines prevents binding to blood components
    Vladimir Subr
    Institute of Macromolecular Chemistry, vvi, Academy of Science of the Czech Republic, Prague, Czech Republic
    J Control Release 135:152-8. 2009
    ..These data indicate that coating Ad5 therapeutics with such polymers will improve blood circulation half-life and deposition at disease sites...
  32. ncbi Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 318:735-40. 2006
  33. ncbi Highly enantioselective synthesis of chiral secondary amines by gold(I)/chiral Brønsted acid catalyzed tandem intermolecular hydroamination and transfer hydrogenation reactions
    Xin Yuan Liu
    Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China
    Org Lett 11:4204-7. 2009
    A method for the synthesis of enantiomerically enriched secondary amines with excellent ee values through the tandem intermolecular hydroamination/transfer hydrogenation of alkynes using a "gold(I) complex-chiral Brønsted acid" protocol ..
  34. ncbi Detection of carcinogenic aromatic amines in the urine of non-smokers
    G Grimmer
    Biochemisches Institut für Umweltcarcinogene, Grosshansdorf, Germany
    Sci Total Environ 247:81-90. 2000
    ..Tobacco smoke contains a complex mixture of chemicals including potent carcinogens such as aromatic amines. In the present study the amounts of several freebase aromatic amines including the potent carcinogens 2-..
  35. ncbi Bladder cancer mortality of workers exposed to aromatic amines: a 58-year follow-up
    Enrico Pira
    Department of Traumatology, Orthopaedics and Occupational Medicine, University of Turin, Turin, Italy
    J Natl Cancer Inst 102:1096-9. 2010
    We previously investigated bladder cancer risk in a cohort of dyestuff workers who were heavily exposed to aromatic amines from 1922 through 1972...
  36. pmc Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study
    Lesley M Butler
    University of California Davis, Department of Public Health Sciences, Division of Epidemiology, Davis, CA 95616, USA
    Mutat Res 638:162-74. 2008
  37. ncbi Pharmacokinetics of gabapentin after a single day and at steady state following the administration of gastric-retentive- extended-release and immediate-release tablets: a randomized, open-label, multiple-dose, three-way crossover, exploratory study in hea
    Toufigh Gordi
    Depomed, Inc, 1360 O Brien Drive, Menlo Park, CA 94025, USA
    Clin Ther 30:909-16. 2008
    ..Therefore, conventional sustained formulations would likely result in decreased bioavailability, as the dosage form would pass through the window of absorption before the drug could be completely released...
  38. pmc Study of neurontin: titrate to effect, profile of safety (STEPS) trial: a narrative account of a gabapentin seeding trial
    Samuel D Krumholz
    Never Again Consulting LLC, Providence, Rhode Island, USA
    Arch Intern Med 171:1100-7. 2011
    ..Seeding trials, clinical studies conducted by pharmaceutical companies for marketing purposes, have rarely been described in detail...
  39. ncbi Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials
    Miroslav Backonja
    Department of Neurology, Anesthesiology, and Rehabilitation Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
    Clin Ther 25:81-104. 2003
    ..Tricyclic antidepressants are considered first-line agents for neuropathic pain, but their use is limited by unwanted side effects and a risk of cardiovascular mortality...
  40. ncbi A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin
    Howard N Bockbrader
    Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Clin Pharmacokinet 49:661-9. 2010
    ..In conclusion, pregabalin appears to have some distinct pharmacokinetic advantages over gabapentin that may translate into an improved pharmacodynamic effect...
  41. ncbi The influence of cationic lipid type on in-vitro release kinetic profiles of antisense oligonucleotide from cationic nanoemulsions
    Tal Hagigit
    Department of Pharmaceutics, The Hebrew University of Jerusalem, Jerusalem, Israel
    Eur J Pharm Biopharm 70:248-59. 2008
    ..Further pharmacokinetic studies are needed to verify our kinetic assumptions and confirm the in-vitro ODN release profile from DOTAP cationic nanoemulsions...
  42. ncbi Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen or hydrogen peroxide and sodium cyanide: sp3 C-H bond activation and carbon-carbon bond formation
    Shun ichi Murahashi
    Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1 3 Machikaneyama, Toyonaka, Osaka 560 8531, Japan
    J Am Chem Soc 130:11005-12. 2008
    Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen in the presence of sodium cyanide and acetic acid gives the corresponding alpha-aminonitriles, which are highly useful intermediates for organic synthesis...
  43. ncbi Stearylamine-bearing cationic liposomes kill Leishmania parasites through surface exposed negatively charged phosphatidylserine
    Antara Banerjee
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    J Antimicrob Chemother 61:103-10. 2008
    ..In the present study, we offer detailed insights into the mechanism of action of these liposomes...
  44. pmc Structural basis for the sequence-dependent effects of platinum-DNA adducts
    Srinivas Ramachandran
    Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7260, USA
    Nucleic Acids Res 37:2434-48. 2009
  45. ncbi Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia
    Shao Rui Chen
    Department of Anesthesiology, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Brain Res 1042:108-13. 2005
    ..These data provide complementary new information that gabapentin administered systemically and spinally can effectively relieve tactile allodynia in this animal model of postherpetic neuralgia...
  46. ncbi Gabapentin in the treatment of neuropathic pain
    Michael I Bennett
    St Gemma s Hospice, Leeds, UK
    Palliat Med 18:5-11. 2004
    ..In patients with neuropathic pain due to cancer, higher response rates might be observed with gabapentin when administered with opioids because of a synergistic interaction...
  47. ncbi In vitro evolution of RNA aptamers recognizing carcinogenic aromatic amines
    Ulrike Brockstedt
    Centre de Recherche, Hôpital Sainte Justine 3175 Côte Sainte Catherine, Montreal, Que, Canada H3T 1C5
    Biochem Biophys Res Commun 313:1004-8. 2004
    ..Among the environmental carcinogens, aromatic amines are known for the fact that they can induce several types of cancers through the formation of so-called DNA ..
  48. pmc Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)
    Bryan T Mott
    NIH Chemical Genomics Center, National Human Genome Research Institute, Bethesda, MD 20892 3370, USA
    Bioorg Med Chem Lett 19:6700-5. 2009
    A series of substituted 6-arylquinazolin-4-amines were prepared and analyzed as inhibitors of Clk4. Synthesis, structure-activity relationships and the selectivity of a potent analogue against a panel of 402 kinases are presented...
  49. ncbi Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity
    Timothy A Hill
    Advanced Synthetic Materials Group, Chemistry Building, School Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia
    Bioorg Med Chem Lett 14:3275-8. 2004
    ..However, introduction of a hydrophobic collar proximal to the charged site was beneficial to dynamin GTPase inhibitory action. The most potent compound was myristoyl trimethyl ammonium bromide (MTMAB, IC(50) 3.15 microM)...
  50. ncbi Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells
    Hong Yuan
    College of Pharmaceutical Science, Zhejiang University, 388 Yuhangtang Road, Hangzhou 310058, People s Republic of China
    Int J Pharm 348:137-45. 2008
    ..The PEG and folate modified SLN could enhance the cellular uptake of SLN and the cellular cytotoxicity of drug by the membrane disturb ability of PEG chains on the SLN surface and the improved endocytosis mediated by folate receptor...
  51. ncbi Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3)
    Ravi D Rao
    Department of Medical Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Cancer 110:2110-8. 2007
    ..On the basis of these data, a multicenter, double-blind, placebo-controlled, crossover, randomized trial was conducted to evaluate the effect of gabapentin on symptoms of chemotherapy-induced peripheral neuropathy (CIPN)...
  52. ncbi Structural analysis of a novel antimutagenic compound, 4-Hydroxypanduratin A, and the antimutagenic activity of flavonoids in a Thai spice, fingerroot (Boesenbergia pandurata Schult.) against mutagenic heterocyclic amines
    G Trakoontivakorn
    Japan International Research Center for Agricultural Sciences (JIRCAS, 1-2 Owashi, Tsukuba, Ibaraki 305-8686, Japan
    J Agric Food Chem 49:3046-50. 2001
    ..All of them strongly inhibited the N-hydroxylation of Trp-P-2. Thus, the antimutagenic effect of compounds 1-6 was mainly due to the inhibition of the first step of enzymatic activation of heterocyclic amines.
  53. ncbi Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit
    Ning Qin
    Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19477 0776, USA
    Mol Pharmacol 62:485-96. 2002
    ..Whether the alpha(2)delta-4 subunit plays a distinct physiological role in select endocrine tissues remains to be demonstrated...
  54. ncbi Myeloperoxidase-derived 2-chlorohexadecanal forms Schiff bases with primary amines of ethanolamine glycerophospholipids and lysine
    Kristin R Wildsmith
    Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, St Louis, MO 63104, United States
    Chem Phys Lipids 139:157-70. 2006
    ..These results show novel Schiff base adducts of alpha-Cl-FALDs with primary amines, which may represent an important fate of alpha-Cl-FALDs.
  55. ncbi Increased salivary fluoride concentrations after post-brush fluoride rinsing not reflected in dental plaque
    M Heijnsbroek
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands
    Caries Res 40:444-8. 2006
    ..It is concluded that the potentially beneficial effect of not rinsing or fluoride rinsing after tooth brushing is not reflected in an increased fluoride concentration in newly formed dental plaque 6 h after brushing...
  56. ncbi Monofunctional gold nanoparticles prepared via a noncovalent-interaction-based solid-phase modification approach
    Xiong Liu
    Nanoscience Technology Center and Department of Chemistry, University of Central Florida, 12424 Research Parkway Suit 400, Orlando, FL 32826, USA
    Small 2:1126-9. 2006
  57. ncbi Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish
    Takashi Sugimura
    National Cancer Center, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:290-9. 2004
    Research leading to the discovery of a series of mutagenic and carcinogenic heterocyclic amines (HCAs) was inspired by the idea that smoke produced during cooking of food, especially meat or fish, might be carcinogenic...
  58. ncbi Cationic liposomes induce apoptosis through p38 MAP kinase-caspase-8-Bid pathway in macrophage-like RAW264.7 cells
    Sayaka Iwaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    J Leukoc Biol 79:184-91. 2006
    ..7 by SA-liposomes was mediated by the MAPK p38 and a caspase-8-dependent Bid-cleavage pathway. Moreover, we found that ROS can contribute intimately to the SA-liposome-induced cell death in RAW264.7...
  59. ncbi Heterocyclic amines and genotype of N-acetyltransferases as risk factors for prostate cancer
    P M Rovito
    Department of Urology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Prostate Cancer Prostatic Dis 8:69-74. 2005
    A variety of carcinogenic heterocyclic amines are produced during the cooking of meat at high temperatures. These carcinogens are metabolized by N-acetyltransferases (NAT), which are polymorphic in the population...
  60. ncbi Leishmanicidal activity of stearylamine-bearing liposomes in vitro
    F Afrin
    Leishmania Group, Indian Institute of Chemical Biology, Calcutta
    J Parasitol 87:188-93. 2001
    ..The cytolytic activity of these liposomes on leishmanial parasites and low toxicity on host macrophages may, thus, find application in the therapy of leishmaniasis...
  61. ncbi Gabapentin in neuropathic pain syndromes: a randomised, double-blind, placebo-controlled trial
    M G Serpell
    University Department of Anaesthesia and Pain Management, Gartnavel General Hospital, 30 Shelly Court, G12 0YN, Scotland, Glasgow, UK
    Pain 99:557-66. 2002
    ..This study shows that gabapentin reduces pain and improves some quality-of-life measures in patients with a wide range of neuropathic pain syndromes...
  62. pmc The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids
    Subramaniam Ramachandran
    Department of Pharmacology, University Wisconsin Madison, School of Medicine and Public Health, 1300 University Ave, Madison, WI 53706, USA
    Eur J Pharmacol 609:19-26. 2009
    ..We found that long alkyl chain primary amines including endogenous amines belonging to the sphingolipid family such as D-erythro-sphingosine and sphinganine ..
  63. ncbi Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications
    Allyn M Kaufmann
    Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Pharm Sci 96:729-46. 2007
    ..Some amines can achieve very high concentrations and induce a dramatic expansion (vacuolization) of the compartment...
  64. ncbi Biogenic amines in Rett syndrome: the usual suspects
    Jean Christophe Roux
    INSERM, U910, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Behav Genet 40:59-75. 2010
    ..suggesting that there is a direct link between the function of the MECP2 protein and the metabolism of biogenic amines. Biogenic amines appear to have an important role in the pathophysiology of Rett syndrome, for several reasons...
  65. ncbi A muscarinic cholinergic mechanism underlies activation of the central pattern generator for locust flight
    Edgar Buhl
    University of Leipzig, Institute of Biology II, Talstr 33, 04103 Leipzig, Germany
    J Exp Biol 211:2346-57. 2008
    ..Furthermore, in addition to octopamine, various other amines including dopamine, tyramine and histamine all induced fictive flight, but not serotonin or the amine-precursor ..
  66. ncbi Biogenic amines modulate olfactory receptor neurons firing activity in Mamestra brassicae
    X Grosmaitre
    Unité de Phytopharmacie et des Médiateurs Chimiques, INRA Centre de Versailles, F 78026 Versailles Cedex, France
    Chem Senses 26:653-61. 2001
    The modulatory effects of the biogenic amines octopamine and serotonin on pheromonal receptor neurons of Mamestra brassicae were investigated...
  67. pmc Spinal gabapentin and antinociception: mechanisms of action
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Korea
    J Korean Med Sci 18:255-61. 2003
  68. ncbi Comments on the history and importance of aromatic and heterocyclic amines in public health
    John H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Mutat Res 506:9-20. 2002
    The carcinogenic risk of aromatic amines in humans was first discovered when a physician related the occurrence of urinary bladder cancer to the occupation of his patients...
  69. pmc A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+)
    Marcel Hollenstein
    Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver BC, V6T 1Z1, Canada
    Nucleic Acids Res 37:1638-49. 2009
    ..cations permits cleavage at significantly higher temperatures than previously observed for DNAzymes with only amines and imidazoles...
  70. ncbi Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis
    Wei Shi Zhang
    Department of Anesthesiology, Changhai Hospital, The Second Military Medical University, Shanghai, China
    Brain Res 1264:57-66. 2009
    ..These results provide the first identification that co-application of dexmedetomidine and gabapentin may synergistically antagonize inflammatory pain, and this might prove to be beneficial in the treatment of arthritic pain...
  71. pmc Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones
    K G Sutton
    Department of Biology, Pfizer Global R and D, Cambridge Laboratories, Cambridge, CB2 2QB
    Br J Pharmacol 135:257-65. 2002
    ..8. The present study is the first to demonstrate that gabapentin directly mediates inhibition of voltage-gated Ca(2+) influx in DRG neurones, providing a potential means for gabapentin to effectively mediate spinal anti-nociception...
  72. pmc Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit
    W Xiao
    Department of Anesthesia, Anesthesia Research Unit, McGill University, Montreal, Quebec, Canada
    Neuroscience 144:714-20. 2007
  73. ncbi omega-Transaminases for the synthesis of non-racemic alpha-chiral primary amines
    Dominik Koszelewski
    Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A 8010 Graz, Austria
    Trends Biotechnol 28:324-32. 2010
    Optically pure amines are highly valuable products or key intermediates for a vast number of bioactive compounds; however, efficient methods for their preparation are rare...
  74. ncbi Evaluation of fecal mutagenicity and colorectal cancer risk
    T M De Kok
    Department of Health Risk Analysis and Toxicology, University of Maastricht, PO Box 616, 6200 MD, Maastricht, Netherlands
    Mutat Res 463:53-101. 2000
    ..These include heterocyclic aromatic amines (HCA) and polycyclic aromatic hydrocarbons (PAH), two exogenous factors that are predominantly ingested as ..
  75. ncbi Gabapentin enhances the analgesic effect of morphine in healthy volunteers
    K Eckhardt
    Dr Margarete Fischer Bosch Institut fuer Klinische Pharmakologie, Stuttgart, Germany
    Anesth Analg 91:185-91. 2000
    ..These results and the good tolerability of GBP should favor clinical trials investigating the clinical relevance of the combination of morphine and GBP for treating severe pain...
  76. ncbi The role of genetic polymorphisms in metabolism of carcinogenic heterocyclic aromatic amines
    R J Turesky
    Division of Chemistry, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Curr Drug Metab 5:169-80. 2004
    More than twenty heterocyclic aromatic amines (HAAs) have been identified in grilled meats, fish, poultry, and tobacco smoke condensate. HAAs are carcinogens and induce tumors at multiple sites in experimental laboratory animals...
  77. ncbi Health risks of heterocyclic amines
    J S Felton
    Biology and Biotechnology Program, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Mutat Res 376:37-41. 1997
    ..and pyrolysis of protein-rich foods induce the formation of potent mutagenic and carcinogenic heterocyclic amines. These same compounds produce tumors at multiple organ sites in both mice and rats...
  78. ncbi Membrane permeability of trace amines: evidence for a regulated, activity-dependent, nonexocytotic, synaptic release
    Mark D Berry
    Department of Chemistry, Brandon University, Brandon, Manitoba, Canada, R7A 6A9
    Synapse 67:656-67. 2013
    Both pre- and post-synaptic effects of trace amines have been demonstrated...
  79. pmc Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals
    M Nagao
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Environ Health Perspect 104:497-501. 1996
    Heterocyclic amines (HCAs) are mutagens/carcinogens to which humans are exposed on almost a daily basis. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) is the most abundant of the various carcinogenic HCAs (present at a level of 0...
  80. ncbi Zinc-catalyzed chemoselective reduction of tertiary and secondary amides to amines
    Shoubhik Das
    Leibniz Institut fur Katalyse e V an der Universitat Rostock, Albert Einstein Strasse 29a, 18059 Rostock, Germany
    Chemistry 17:12186-92. 2011
    ..The presented hydrosilylations proceed with excellent chemoselectivity in the presence of sensitive ester, nitro, azo, nitrile, olefins, and other functional groups, thus making the method attractive for organic synthesis...
  81. ncbi The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2
    Alexandra Tran-Van-Minh
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 30:12856-67. 2010
    ..In contrast, the internalization of α2δ-2 was unaffected by GBP. We conclude that GBP acts by preventing the recycling of α2δ-2 from Rab11-positive recycling endosomes to the plasma membrane...
  82. ncbi 2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2
    Danielle K Neff
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 17:6467-71. 2007
    ..These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility...
  83. pmc Identification of equine cecal bacteria producing amines in an in vitro model of carbohydrate overload
    S R Bailey
    Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
    Appl Environ Microbiol 69:2087-93. 2003
    ..The products of fermentation which trigger acute laminitis are, as yet, unknown; however, vasoactive amines are possible candidates...
  84. pmc Cadmium alters the biotransformation of carcinogenic aromatic amines by arylamine N-acetyltransferase xenobiotic-metabolizing enzymes: molecular, cellular, and in vivo studies
    Nilusha Ragunathan
    Universite Paris Diderot Paris 7, unité de Biologie Fonctionnelle et Adaptative, Centre National de la Recherche Scientifique, Paris, France
    Environ Health Perspect 118:1685-91. 2010
    ..Exposure to both Cd and carcinogenic organic compounds, such as polycyclic aromatic hydrocarbons or aromatic amines (AAs), is a common environmental problem...
  85. ncbi Once-daily gastroretentive gabapentin for postherpetic neuralgia: integrated efficacy, time to onset of pain relief and safety analyses of data from two phase 3, multicenter, randomized, double-blind, placebo-controlled studies
    Richard L Rauck
    Center for Clinical Research, Winston Salem, North Carolina, USA
    J Pain Symptom Manage 46:219-28. 2013
    ..Treatment options for postherpetic neuralgia (PHN), a complication of herpes zoster, are commonly unsatisfactory and associated with adverse events...
  86. ncbi Gastroretentive gabapentin (G-GR) formulation reduces intensity of pain associated with postherpetic neuralgia (PHN)
    Christine N Sang
    Translational Pain Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin J Pain 29:281-8. 2013
    ..To evaluate the safety and efficacy of a once-daily gastroretentive formulation of gabapentin (G-GR; 1800 mg)...
  87. ncbi Effects of dietary amines on the gut and its vasculature
    Kenneth J Broadley
    Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, UK
    Br J Nutr 101:1645-52. 2009
    Trace amines, including tyramine and beta-phenylethylamine (beta-PEA), are constituents of many foods including chocolate, cheeses and wines and are generated by so-called 'friendly' bacteria such as Lactobacillus, Lactococcus and ..
  88. pmc Simple organic molecules as catalysts for enantioselective synthesis of amines and alcohols
    Daniel L Silverio
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Nature 494:216-21. 2013
    ..organoboron reagents with imines and carbonyls; the products of the reactions are enantiomerically pure amines and alcohols, which might serve as intermediates in the preparation of biologically active molecules...
  89. ncbi Deactivation of gold(I) catalysts in the presence of thiols and amines--characterisation and catalysis
    Paul C Young
    Institute of Chemical Sciences, Heriot Watt University, Edinburgh, EH14 4AS, United Kingdom
    Dalton Trans 42:9645-53. 2013
    Thiols and amines, which are common heteroatom nucleophiles in gold-catalysed reactions, are known to dampen the reactivity of gold catalysts...
  90. ncbi Predicting mutagenicity of aromatic amines by various machine learning approaches
    Max K Leong
    Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 97401, Taiwan
    Toxicol Sci 116:498-513. 2010
    Aromatic amines are prevalently used in a wide variety of industries and are ubiquitous in foods and environment...
  91. ncbi Oxidation of tertiary amines by cytochrome p450-kinetic isotope effect as a spin-state reactivity probe
    Chunsen Li
    State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
    Chemistry 15:8492-503. 2009
    ..This capability of the N-oxo derivatives of aromatic amines to transfer oxygen to the heme, and thereby generate Cpd I, is in good accord with experimental data previously ..
  92. pmc Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies
    Fatma Sultan Kilic
    Department of Pharmacology, Eskisehir Osmangazi University, Medical School, Eskisehir, Turkey
    Indian J Med Res 135:630-5. 2012
    ..Thus, clinical studies have been carried out especially for neuropathic syndroms. This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats...
  93. ncbi On the interaction of aliphatic amines and ammonium ions with carboxylic acids in solution and in receptor pockets
    Peter I Nagy
    Center for Drug Design and Development, The University of Toledo, Toledo, Ohio 43606, USA
    J Phys Chem B 116:5425-36. 2012
    Association energies of the acetate ion with cationic amines bearing one to three methyl groups were calculated in the range of -14 to -17 kcal/mol in aqueous solution by means of the IEF-PCM method at the CCSD(T)/CBS//MP2/aug-cc-pvdz and ..
  94. ncbi Chiral recognition and kinetic resolution of aromatic amines via supramolecular chiral nanocapsules in nonpolar solvents
    Toshiyuki Kida
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Am Chem Soc 135:3371-4. 2013
    ..In addition, kinetic resolution of 1 through enantioselective N-acylation was accomplished with an enantiomeric excess of up to 91%...
  95. pmc The interaction of gabapentin and N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on mechanical allodynia in rats with a spinal nerve ligation
    Jong Yeon Park
    Department of Anesthesiology and Pain Medicine, University of Ulsan, College of Medicine, Seoul Asan Medical Center, Songpa Gu, Seoul, Korea
    J Korean Med Sci 23:678-84. 2008
    ..These results suggest that activation of adenosine A1 receptors at the spinal level is required for the synergistic interaction on the mechanical allodynia...
  96. ncbi N-alkyl-5H-pyrido[4,3-b]indol-1-amines and derivatives as novel urotensin-II receptor antagonists
    Yonghui Wang
    Oncology CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 18:4936-9. 2008
    ..screening of our compound collection led to the discovery of a novel series of N-alkyl-5H-pyrido[4,3-b]indol-1-amines as urotensin-II receptor antagonists...
  97. ncbi Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines
    Xinhong Yu
    School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China
    Org Biomol Chem 6:2037-46. 2008
    The utilisation of chiral secondary amines as promoters for asymmetric cascade reactions has been subject of intensive research in asymmetric organocatalysis in the past few years...
  98. ncbi Synthesis of 3-(1,2,3-triazol-1-yl)- and 3-(1,2,3-triazol-4-yl)-substituted pyrazolo[3,4-d]pyrimidin-4-amines via click chemistry: potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase
    Michael Klein
    Department of Chemistry, University of Gothenburg, Kemivägen 10 41296 Gothenburg, Sweden
    Org Biomol Chem 7:3421-9. 2009
    Efficient routes to 3-(1,2,3-triazol-1-yl)- and 3-(1,2,3-triazol-4-yl)pyrazolo[3,4-d]pyrimidin-4-amines using a one-pot two-step reaction are presented...
  99. ncbi Mutagenic potency of food-derived heterocyclic amines
    James S Felton
    Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA
    Mutat Res 616:90-4. 2007
    ..The other factor of 20 is not clearly understood but is downstream from the oxidation step. The application of QSAR (chemical characteristics) to biological principles related to mutagenesis is explored in this report...
  100. ncbi Boric acid: a highly efficient catalyst for transamidation of carboxamides with amines
    Thanh Binh Nguyen
    Centre de Recherche de Gif sur Yvette, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif sur Yvette Cedex, France
    Org Lett 14:3202-5. 2012
    A novel method of transamidation of carboxamides with amines using catalytic amounts of readily available boric acid under solvent-free conditions has been developed...
  101. pmc Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy
    Sarah D Cady
    Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA
    J Am Chem Soc 133:4274-84. 2011

Research Grants74

  1. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..The nickel/his-tag interaction provides a mechanism for adsorbing O10H6, freeing the protonated ornithine amines to maximize DNA capture...
  2. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..5 hr in mice whereas half-lives of 1-2 min are the norm for chemically similar biogenic amines such as seratonin and dopamine...
  3. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..5 hr in mice whereas half-lives of 1-2 min are the norm for chemically similar biogenic amines such as serotonin and dopamine...
  4. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    ..There is ample evidence linking biogenic amines to behaviors associated with the establishment of social hierarchies in both vertebrates and invertebrates, but ..
  5. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..Heterocyclic aromatic amines (HAs) require additional activation by N,O-acetyltransferase (NAT2)...
    M Firoze Khan; Fiscal Year: 2010
    Our long-term objective is to elucidate the mechanisms of the splenic toxicity of aromatic amines, and to develop preventive and therapeutic strategies...
  7. Organic Cation Transporter PMAT: Physiological Function and Role in Drug Disposit
    Joanne Wang; Fiscal Year: 2013
    ..are also likely to be involved in various physiological pathways through their uptake of endogenous bioactive amines. The plasma membrane monoamine transporter (PMAT) is a new polyspecific organic cation transporter first cloned ..
  8. Genomic profiling of yeast resistance to AFB1, a P450-activated carcinogen
    MICHAEL THOMAS FASULLO; Fiscal Year: 2013
    ..a variety of carcinogens, including aflatoxin B1 (AFB1), benzo[a]pyrene dihydrodiol (BaP-DHD), and heterocyclic amines (HA, food carcinogens)...
  9. How do Amine Neurons Work?
    Edward A Kravitz; Fiscal Year: 2013
    ..including mood disorders, schizophrenia, attention-deficit hyperactivity disorder and drug abuse in which the amines dopamine, serotonin and norepinephrine all have been directly implicated...
  10. Case-Cohort Study of Cancers in Excess in Poultry Workers
    Eric S Johnson; Fiscal Year: 2013
    ..program), but also to other occupational carcinogens, including polycyclic aromatic hydrocarbons, heterocyclic amines, nitrosamines, benzene, etc...
  11. Estrogen and TMJ Pain
    Phillip R Kramer; Fiscal Year: 2013
    ..Since GABA, glycine and sympathomimetic amines can inhibit hypersensitivity the knock-down of Gabr[unreadable]6, Glr[unreadable]2 and Adr[unreadable]1 expression ..
  12. Exocytosis and Coupled Endocytosis in Neuroendocrine Cells
    JOHN DAVID CASTLE; Fiscal Year: 2010
    ..In these cells, exocytosis of dense-core vesicles (DCVs) is used to secrete hormones and biogenic amines that regulate most of man's internal functions, and endocytosis recycles DCV membranes for reutilization...
  13. Preclinical development of a novel antibacterial for Clostridium difficile diseas
    George E Wright; Fiscal Year: 2012
    ..Compound 359E and analogs are tertiary amines, readily form water soluble salts, and are highly effective against Cdiff in vitro and in vivo...
    Lawrence C Sowers; Fiscal Year: 2013
    ..or bromamines might facilitate the delivery of reactive molecules to the nucleus, and that some tertiary amines, including nicotine, might catalyze halogen transfer from the haloamines to cytosine...
    Lori A Setton; Fiscal Year: 2013
    ..Curcumin will be modified to include chemically reactive amines for reversible coupling to ELP...
  16. Studies toward the development of monoamine oxidase B specific inhibitors
    ERIKA MARIE MILCZEK; Fiscal Year: 2010
    ..flavoproteins responsible for the oxidative metabolism of biogenic amine neurotransmitters as well as dietary amines which prevent the latter from behaving as false neurotransmitters...
  17. Synthesis, StructUre and Replication of Carcirogen-Modified Oligonucleotides
    Carmelo J Rizzo; Fiscal Year: 2013
    ..In recent years, a number of heterocyclic amines (HCAs) have been isolated from cooked meats;the HCAs are highly mutagenic in bacterial assays and potent ..
  18. Hormonal Modulation of Aggression in Drosophila
    Edward A Kravitz; Fiscal Year: 2013
    ..A single gene, fruitless, specifies both how flies fight and who they court. Amines have been shown to be important in aggression in all species of animals examined thus far...
  19. Transport and Inhibition in a Biogenic Amine Transporter
    Satinder Singh; Fiscal Year: 2009
    ..Pumps for the biogenic amines are of particular significance because their dysfunction has been implicated in a number of debilitating ..
  20. Transport and Inhibition in a Biogenic Amine Transporter
    SATINDER KAUR SINGH; Fiscal Year: 2012
    ..Pumps for the biogenic amines are of particular significance because their dysfunction has been implicated in a number of debilitating ..
  21. Fluorescent Copper Probes for Intracellular Imaging
    Christoph J Fahrni; Fiscal Year: 2013
    ..reactions, and is required in processes such as respiration, superoxide disproportionation, degradation of amines, or for iron mobilization and uptake...
  22. Gut L-Histidine Metabolism and Histamine Signaling in Colonic Neoplasia
    James Versalovic; Fiscal Year: 2013
    ..Based on recent findings, intestinal bacteria can convert amino acids, such as L-histidine, into biogenic amines, such as histamine, that suppress pro-inflammatory cytokine production by impeding MAP kinase signaling...
  23. Intellectual and Development Disabilities Research Center
    Marc Yudkoff; Fiscal Year: 2013
    ..analyses, including (i) the study of second messenger systems in living cells;(ii) measurements of biogenic amines and amino acids in brain tissues;(iii) mass spectrometry assays of stable isotopes for kinetic studies of ..
  24. Developing Neurons
    ..specification? Our proposed research has four specific aims that analyze activity-dependent expression of biogenic amines (dopamine and serotonin) in the brain (aims 1 &2), address the function of natural environmental stimuli in ..
  25. Radiolabled MAO-B Substrates for Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    ..are oxidized to the corresponding dihydropyridinium salts that spontaneously hydrolyze to release polar amines. The polar radiolabeled products from MAO-B enzymatic oxidation will accumulate at the site of enzyme action, thus ..
    Donald F Hunt; Fiscal Year: 2013
    ..for increasing the charge state of peptides and proteins by converting neutral or acidic, amino-acid residues to amines that can then be protonated and function as hydrogen donors...
  27. Chemical markers of heterocyclic aromatic amines for human biomonitoring
    Robert J Turesky; Fiscal Year: 2011
    The broad, long-term objective of this application is to assess the cancer risk posed by heterocyclic aromatic amines (HAAs), an important class of genotoxicants formed in cooked meats and tobacco smoke condensate...
  28. Multiethnic Cohort Study of Diet and Cancer
    Laurence N Kolonel; Fiscal Year: 2012
    ..g., trans fatty acids, heme iron, glycemic load, heterocyclic amines), study of some less common sites (e.g...
  29. Regulation of ITK in Lung Allergy
    Constantine D Tsoukas; Fiscal Year: 2010
    ..production of IgE antibodies, recruitment of eosinophils, and the subsequent release of inflammatory vasoactive amines and lipid mediators...
  30. Aromatic Amine-DNA Lesions: Mutagenicity and Repair
    Suse Broyde; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polycyclic aromatic amines, heterocylic amines and nitroarenes are environmental carcinogens that are present in many cooked and broiled foods, notably meats, products of fuel combustion such as diesel ..
  31. Self-assembling Biomimetic Hydrogels with Bioadhesive Properties for Intervertebr
    ..In addition, CS can be modified with aldehyde groups (CS aldehyde), allowing it to react with amines via Schiff's base reaction, thus rendering the hydrogel bioadhesive upon contact with amines of the ..
  32. Molecular mechanisms of olfaction in mammals
    Linda B Buck; Fiscal Year: 2012
    ..Screening of TAARs with diverse odorants revealed ligands for several TAARs, all of which are small volatile amines. Strikingly, at least three mouse TAARs recognize amines found in urine...
  33. Cortical GABA in MDD and Primary Insomnia with Magnetic Resonance Spectroscopy
    John W Winkelman; Fiscal Year: 2013
    ..Although the preponderance of studies have focused on the role of the biogenic amines and the hypothalamic-pituitary-adrenal (HPA) axis, recent evidence suggests that the neurotransmitter gamma-..
  34. The role of heterocyclic aromatic amines in breast cancer
    Robert J Turesky; Fiscal Year: 2010
    ..Heterocyclic aromatic amines (HAAs) are formed during the cooking of meats...
  35. Array development of anti-inflammatory peptoid-graft polymers for islet delivery
    Matthew Webber; Fiscal Year: 2013
    ..will be a synthetic [unreadable]-amino alcohol prepared via step-growth polymerization of diepoxides and primary amines on the peptoid...
  36. Understanding the function of trace amine-associated (TAARs)
    Kyoung hye Yoon; Fiscal Year: 2013
    ..Screening of TAARs with diverse odorants revealed ligands for several TAARs, all of which are small volatile amines. Interestingly, at least three mouse TAARs recognize amines found in urine...
  37. Neuropeptides, Social Stress and Drugs of Abuse
    Klaus A Miczek; Fiscal Year: 2013
    ..fluid, high performance liquid chromatography for assaying these samples to determine dopamine and other amines and behavioral measures as indices of neuroadaptive changes...
    Michael W Duffel; Fiscal Year: 2010
    ..alcohols derived from alkyl-substituted polycyclic aromatic hydrocarbons, hydroxylamine metabolites of aromatic amines and nitroaromatics, and allylic alcohols...
  39. Secretion-associated dynamic of the plasma membrane
    Arun Anantharam; Fiscal Year: 2010
    ..When triggered by Ca2+, neuroendocrine cells release biogenic amines and neuropeptides into the extracellular space through fusion of dense core granules with the plasma membrane...
  40. GPCR Signaling Through a Novel NF-kB Pathway
    Linda M McAllister-Lucas; Fiscal Year: 2013
    ..These include a diverse array of peptide ligands, amines, glycoproteins and enzymes...
  41. LC-MS Analysis of DNA Adducts of Aromatic Amines: Relationship to Bladder Cancer
    Paul Vouros; Fiscal Year: 2013
    ..Aromatic amines, compounds found in cigarette smoke, hair dyes and other environmental sources have been implicated in a variety ..
  42. TAAR1 polymorphisms in rhesus monkeys
    Gregory M Miller; Fiscal Year: 2010 applicant): Rhesus monkey Trace Amine-Associated Receptor 1 (TAAR1) responds to a wide spectrum of endogenous amines (including the "trace" amines 2-phenylethylamine and tyramine, and the common biogenic amines dopamine, ..
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..Pharmacological and neuroanatomical strategies are set forth to distinguish the two catechol-amines. 2. Characterization of norepinephrine neurotransmission in behaving animals...
  44. Development of anti-CXCR4 compounds to block breast cancer metastasis
    Hyunsuk Shim; Fiscal Year: 2013
    ..We have developed an intriguing novel class of pyrimidine amines with unique partial anti-CXCR4 activity...
  45. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative
    JOHN J BOWSER; Fiscal Year: 2013
    ..Therefore, from a chemical stability standpoint, it can be operated with alcohols, organic acids, ketones, amines and aprotic solvents, to name a few...
  46. Imaging neuromodulation in the brain
    David J Anderson; Fiscal Year: 2013
    ..with the latter view, multiple neuromodulatory systems have been implicated in arousal, including biogenic amines (BAs), acetylcholine (ACh), hormones and neuropeptides such as orexin...
  47. Development of Anti-OLAM Aptamers as Novel Analgesics
    John G Bruno; Fiscal Year: 2012
    ..g., primary amines, methyl, thiol groups, etc...
  48. Screening Assay for Human TAAR1 Ligands
    Brian P Gilmour; Fiscal Year: 2010
    ..Until recently, it was postulated that the trace amines worked primarily through modulation of the activity of the classical biogenic amines...
  49. UPRH Biomedical Research Improvement Program
    Antonio E Alegria; Fiscal Year: 2010
    ..A third project proposes the design of improved methods for the estereoselective preparation of diverse kind of amines with potential neurological effects...
  50. Mechanism of immune dysregulation secondary to methamphetamine abuse.
    Raghava Potula; Fiscal Year: 2013
    ..For the first time, we showed that trace amine associated receptor (TAAR1, a novel receptor activated by amines) is stimulated by METH on T cells implying that some of METH effects may be attributable to activity of this ..
  51. Molecular Imaging of the Lung Using Hyperpolarized Carbon-13 Compounds
    Rahim R Rizi; Fiscal Year: 2013
    ..Specifically, these include the regulation of glycolytc intermediates, amino acid levels, and vasoactive amines in both the lung tissue and the blood plasma...
  52. Roles of Mast Cells in Inflammatory Pain
    Devavani Chatterjea; Fiscal Year: 2010
    ..roles of inflammatory cytokines such as TNF-a, IL-6, 8, 12 and final mediators such as endothelins and sympathetic amines have been described in rodent models of hypernociception...
  53. Methods for Measuring Sub-second Neurotransmitter Interactions
    Michael A Johnson; Fiscal Year: 2013
    ..microelectrodes, offers sufficient temporal resolution to measure the release and uptake of electroactive biogenic amines such as dopamine, its use in characterizing such sub-second neurotransmitter/neuromodulator interactions is ..
    ANNETTE FLECKENSTEIN; Fiscal Year: 2010
    ..This, in turn, may enhance understanding of a variety of DAT-associated disorders ranging from stimulant abuse to neurodegenerative diseases such as Parkinson's disease. ..
  55. TAAR1 and the Control of Wakefulness
    Thomas S Kilduff; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The trace amines (TAs), endogenous amino acid metabolites previously considered "false neurotransmitters," have recently been shown to act as endogenous ligands for trace amine-associated receptor 1 (..
  56. Development of VesiVax Carbohydrate Conjugation Chemistry
    Gary Fujii; Fiscal Year: 2013
    ..application, we will develop a simple carbohydrate conjugation method that couples polysaccharide antigens to free amines on either a protein scaffold or liposomes containing lipid amines...
  57. Sortase-mediated protein engineering for the study of host-pathogen interactions
    Hidde L Ploegh; Fiscal Year: 2013
    ..This intermediate is then resolved by nucleophilic attack, using synthetic primary amines or proteins suitably equipped with Gly or Ala as the N- terminus...
  58. Dopaminergic Modulation of Brain Development
    Gregg D Stanwood; Fiscal Year: 2013
    ..Dopamine and other biogenic amines serve as neurotransmitters in the mature nervous system, and are also prominent drug targets in the treatment of ..
  59. Catalytic Aerobic Oxidations for Pharmaceutical Synthesis: Flow-Reaction Methods
    Shannon S Stahl; Fiscal Year: 2010
    ..aerobic alcohol oxidation/enantioselective ketone hydrogenation, and (2) the conversion of alcohols to (chiral) amines via sequential aerobic alcohol oxidation/(enantioselective) reductive amination reactions...
  60. Sequence Effects of Arylamine-DNA Adducts: Repair and Replication
    Bongsup P Cho; Fiscal Year: 2013
    ..Aromatic amines are well-known environmental human carcinogens...
  61. Schiff base forming sunscreen filters for long-wear UV protection
    Steven Isaacman; Fiscal Year: 2012
    ..TiO2 and ZnO particles, acts as a hetero bifunctional linker and forms temporary covalent bonds with epidermal amines, chemically "linking" the particles to the skin...
  62. Chemoenzymatic studies of aminoglycoside-resistance enzymes towards new drugs
    Sylvie Garneau-Tsodikova; Fiscal Year: 2013 chemically modify specific amine groups on an aminoglycoside that contains a series of chemically identical amines. A few existing examples that use solely chemical syntheses are too demanding on research time and cost and are ..
    Joseph Toce; Fiscal Year: 1991
    ..Recently, in a preliminary report, a group of sulfonated bislactobionic acid amines have been demonstrated to possess anticoagulant and antiocclusive properties comparable to those currently ..
    TIMOTHY YOSHINO; Fiscal Year: 1999
    ..Biomphalaria glabrata leads to a depression in oviposition and concurrently in the levels of several host biogenic amines in the CNS and/or plasma, including L-dopa, dopamine, and serotonin...
    Stephen Schwartz; Fiscal Year: 2001
    ..Oral carcinogens derived from these exposures include N-nitrosamines, polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic amines, and acetaldehyde that are activated and detoxified by enzyme systems in vivo to ..
    Daniel Nebert; Fiscal Year: 2002
    ..CYP1A2 substrates include environmentally important heterocyclic amines, nitrosamines, aflatoxins, nitrated polycyclic aromatic hydrocarbons, and arylamines such as 4-aminobiphenyl (ABP)...
    ALFRED CIARLONE; Fiscal Year: 1980
    This study is designed to show a relationship between local anesthetic induced convulsions and changes in brain amines, i.e., serotonin, norepinephrine, and dopamine...
    Martin Kelly; Fiscal Year: 2002
    ..E2) modulates opioidergic (beta-endorphin) tone and subsequently the neurosecretion of hypothalamic peptides and amines and activation of reward pathways in the female...
    Robert Katzman; Fiscal Year: 1980
    The principal clinical and basic investigations constituting Biogenic Amines and Neurological Disorders are concerned with dopamine (DA) neuronal systems and DA receptors...
    Duane Miller; Fiscal Year: 1992
    ..while capable of binding to dopamine receptors, have a lower affinity for D2 and D1 dopamine receptors than parent amines which can exist in both protonated (charged) and unprotonated (uncharged) forms at physiological pH...
    Jennifer Hu; Fiscal Year: 1992
    ..Cytochrome P450 lAl (CYP 1A1), is involved in the bioactivation of a number of procarcinogenes, including aromatic amines and other hydrocarbons, important human lung carcinogens...
  72. Cytochrome P450-reductase interactions in P450 1A subfamily
    GRAZYNA SZKLARZ; Fiscal Year: 2007
    ..hepatic P450, oxidizes a number of drugs and plays a major role in the metabolic activation of heterocyclic amines to genotoxic products...
    EDITH HENDLEY; Fiscal Year: 1980
    ..The major mode of disposition of these amines is by neuronal membrane uptake back into the nerve terminals, leaving a minor portion available for stimulation of ..
  74. Metabolism and Carcinogenicity of Heterocyclic Amines
    TERRY ZENSER; Fiscal Year: 2007
    ..During the cooking process, genotoxic heterocyclic amines (HCAs), i.e., 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), are formed which can initiate colon cancer...