chlorhexidine

Summary

Summary: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Top Publications

  1. ncbi The effect of cord cleansing with chlorhexidine on neonatal mortality in rural Bangladesh: a community-based, cluster-randomised trial
    Shams El Arifeen
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Lancet 379:1022-8. 2012
  2. ncbi Topical application of chlorhexidine to neonatal umbilical cords for prevention of omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial
    Sajid Soofi
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 379:1029-36. 2012
  3. pmc Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomised trial
    Luke C Mullany
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21211, USA
    Lancet 367:910-8. 2006
  4. ncbi Root canal irrigants
    Matthias Zehnder
    Department of Preventive Dentistry, Periodontology, and Cariology, Division of Endodontology, University of Zürich Center for Dental Medicine, Switzerland
    J Endod 32:389-98. 2006
  5. pmc Antibacterial and physical properties of calcium-phosphate and calcium-fluoride nanocomposites with chlorhexidine
    Lei Cheng
    Biomaterials and Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, 21201, USA
    Dent Mater 28:573-83. 2012
  6. ncbi Effect of daily chlorhexidine bathing on hospital-acquired infection
    Michael W Climo
    Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA 23249, USA
    N Engl J Med 368:533-42. 2013
  7. ncbi Effectiveness of selected materials against Enterococcus faecalis: part 3. The antibacterial effect of calcium hydroxide and chlorhexidine on Enterococcus faecalis
    Yu Heng Lin
    Department of Endodontics, Case Western Reserve University, School of Dentistry, Cleveland, OH 44106 4905, USA
    J Endod 29:565-6. 2003
  8. ncbi Inactivation of the antibacterial activity of iodine potassium iodide and chlorhexidine digluconate against Enterococcus faecalis by dentin, dentin matrix, type-I collagen, and heat-killed microbial whole cells
    Isabelle Portenier
    Department of Endodontics, Dental Faculty, University of Oslo, Norway
    J Endod 28:634-7. 2002
  9. ncbi Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gel in the treatment of periodontitis: a randomized multicenter trial
    Michele Paolantonio
    Department of Periodontology, School of Dentistry, University G D Annunzio, Chieti, Italy
    J Periodontol 80:1479-92. 2009
  10. ncbi Effectiveness of 2% chlorhexidine gel and calcium hydroxide against Enterococcus faecalis in bovine root dentine in vitro
    B P F A Gomes
    Endodontic Department, Piracicaba Dental School, State University of Campinas UNICAMP, Piracicaba, SP, Brazil
    Int Endod J 36:267-75. 2003

Detail Information

Publications371 found, 100 shown here

  1. ncbi The effect of cord cleansing with chlorhexidine on neonatal mortality in rural Bangladesh: a community-based, cluster-randomised trial
    Shams El Arifeen
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Lancet 379:1022-8. 2012
    ..We aimed to assess the effectiveness of two cord-cleansing regimens with the promotion of dry cord care in the prevention of neonatal mortality...
  2. ncbi Topical application of chlorhexidine to neonatal umbilical cords for prevention of omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial
    Sajid Soofi
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 379:1029-36. 2012
    ..We aimed to assess the effect of umbilical-cord cleansing with 4% chlorhexidine (CHX) solution, with or without handwashing with antiseptic soap, on the incidence of omphalitis and neonatal ..
  3. pmc Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomised trial
    Luke C Mullany
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21211, USA
    Lancet 367:910-8. 2006
    ..Omphalitis contributes to neonatal morbidity and mortality in developing countries. Umbilical cord cleansing with antiseptics might reduce infection and mortality risk, but has not been rigorously investigated...
  4. ncbi Root canal irrigants
    Matthias Zehnder
    Department of Preventive Dentistry, Periodontology, and Cariology, Division of Endodontology, University of Zürich Center for Dental Medicine, Switzerland
    J Endod 32:389-98. 2006
    ..Furthermore, some technical aspects of irrigating the root canal system are discussed, and recent trends are critically inspected...
  5. pmc Antibacterial and physical properties of calcium-phosphate and calcium-fluoride nanocomposites with chlorhexidine
    Lei Cheng
    Biomaterials and Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, 21201, USA
    Dent Mater 28:573-83. 2012
    ..Other studies have incorporated chlorhexidine (CHX) particles into dental composites...
  6. ncbi Effect of daily chlorhexidine bathing on hospital-acquired infection
    Michael W Climo
    Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA 23249, USA
    N Engl J Med 368:533-42. 2013
    Results of previous single-center, observational studies suggest that daily bathing of patients with chlorhexidine may prevent hospital-acquired bloodstream infections and the acquisition of multidrug-resistant organisms (MDROs).
  7. ncbi Effectiveness of selected materials against Enterococcus faecalis: part 3. The antibacterial effect of calcium hydroxide and chlorhexidine on Enterococcus faecalis
    Yu Heng Lin
    Department of Endodontics, Case Western Reserve University, School of Dentistry, Cleveland, OH 44106 4905, USA
    J Endod 29:565-6. 2003
    ..Irrigation with chlorhexidine gluconate has been suggested based on its antimicrobial effect and substantivity...
  8. ncbi Inactivation of the antibacterial activity of iodine potassium iodide and chlorhexidine digluconate against Enterococcus faecalis by dentin, dentin matrix, type-I collagen, and heat-killed microbial whole cells
    Isabelle Portenier
    Department of Endodontics, Dental Faculty, University of Oslo, Norway
    J Endod 28:634-7. 2002
    The antibacterial activity of chlorhexidine digluconate and iodine potassium iodide on Enterococcus faecalis A197A was tested in the presence of dentin, dentin matrix, dentin pretreated by EDTA and citric acid, collagen, and heat-killed ..
  9. ncbi Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gel in the treatment of periodontitis: a randomized multicenter trial
    Michele Paolantonio
    Department of Periodontology, School of Dentistry, University G D Annunzio, Chieti, Italy
    J Periodontol 80:1479-92. 2009
    The use of locally delivered antibacterials containing chlorhexidine (CHX) was proposed to improve the effectiveness of non-surgical periodontal treatment...
  10. ncbi Effectiveness of 2% chlorhexidine gel and calcium hydroxide against Enterococcus faecalis in bovine root dentine in vitro
    B P F A Gomes
    Endodontic Department, Piracicaba Dental School, State University of Campinas UNICAMP, Piracicaba, SP, Brazil
    Int Endod J 36:267-75. 2003
    To evaluate the effectiveness of 2% chlorhexidine gluconate gel and calcium hydroxide (Ca(OH)2) as intracanal medicaments against Enterococcus faecalis.
  11. ncbi Eradication of Enterococcus faecalis biofilms by cetrimide and chlorhexidine
    María Teresa Arias-Moliz
    Department of Microbiology, School of Dentistry, University of Granada, Granada, Spain
    J Endod 36:87-90. 2010
    ..faecalis by using irrigating solutions. The purpose of this study was to assess the efficacy of cetrimide and chlorhexidine (CHX), alone and in association, in combined and alternating form, in eradicating biofilms of E. faecalis.
  12. ncbi Antimicrobial activity of sodium hypochlorite associated with intracanal medication for Candida albicans and Enterococcus faecalis inoculated in root canals
    Marcia Carneiro Valera
    Department of Restorative Dentistry, Sao Paulo State University, Sao Jose dos Campos, Brazil
    J Appl Oral Sci 17:555-9. 2009
    ..The purpose of this study was to evaluate the action of sodium hypochlorite (NaOCl) associated with an intracanal medication against Candida albicans and Enterococcus faecalis inoculated in root canals...
  13. ncbi Influence of irrigation regimens on the adherence of Enterococcus faecalis to root canal dentin
    Anil Kishen
    Department of Restorative Dentistry, Faculty of Dentistry, National University of Singapore, Singapore
    J Endod 34:850-4. 2008
    ..With the use of chlorhexidine (CHX), the force of adhesion increased, but the adherence assay showed a reduction in the number of adhering ..
  14. ncbi Antimicrobial efficacy of chlorhexidine against bacteria in biofilms at different stages of development
    Ya Shen
    Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    J Endod 37:657-61. 2011
    ..The aim of this study was to examine the susceptibility of multispecies biofilms at different phases of growth to root canal irrigants...
  15. ncbi Residual and antimicrobial activity of final irrigation protocols on Enterococcus faecalis biofilm in dentin
    Pilar Baca
    Department of Preventive and Operative Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Endod 37:363-6. 2011
    ..The aim of this study was to evaluate the residual antimicrobial activity and the capacity to eradicate Enterococcus faecalis biofilm of different irrigating solutions, alone and in combination, in a dentin-volumetric test...
  16. ncbi Effect of different chlorhexidine formulations in mouthrinses on de novo plaque formation
    M Quirynen
    Department of Periodontology, Research Group for Microbial Adhesion, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium
    J Clin Periodontol 28:1127-36. 2001
    b>Chlorhexidine (CHX) 0...
  17. ncbi Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis
    Sonia O Labeau
    Faculty of Healthcare Vesalius, University College Ghent, Ghent, Belgium
    Lancet Infect Dis 11:845-54. 2011
    ..systematic review and random effects meta-analysis of randomised trials to assess the effect of oral care with chlorhexidine or povidone-iodine on the prevalence of ventilator-associated pneumonia versus oral care without these ..
  18. ncbi Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis
    Rabih O Darouiche
    Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 362:18-26. 2010
    ..We hypothesized that preoperative skin cleansing with chlorhexidine-alcohol is more protective against infection than is povidone-iodine.
  19. ncbi Antimicrobial efficacy of a polymeric chlorhexidine release device using in vitro model of Enterococcus faecalis dentinal tubule infection
    Yoon Lee
    Department of Conservative Dentistry, Wonkwang University Dental Hospital, Daejeon, Korea
    J Endod 34:855-8. 2008
    This study aimed to assess the antimicrobial efficacy of a novel polymeric chlorhexidine-controlled release device as an intracanal medicament...
  20. ncbi Antimicrobial efficacy of chlorhexidine and two calcium hydroxide formulations against Enterococcus faecalis
    Edgar Schafer
    Poliklinik für Zahnerhaltung, University School of Dentistry, Munster, Germany
    J Endod 31:53-6. 2005
    The purpose of this study was to investigate the efficacy of chlorhexidine (CHX) and calcium hydroxide (Ca(OH2) against Enterococcus faecalis in vitro. Extracted single-rooted human teeth were instrumented up to size 40...
  21. ncbi The properties and applications of chlorhexidine in endodontics
    Z Mohammadi
    Department of Endodontics, School of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran
    Int Endod J 42:288-302. 2009
    ..To reduce or eliminate bacteria, various irrigation solutions have been advocated. Chlorhexidine is a cationic molecule, which can be used during treatment. It has a wide range of antimicrobial activity...
  22. ncbi Conofocal microscopy study of undisturbed and chlorhexidine-treated dental biofilm
    E Zaura-Arite
    Department of Cariology/Endodontology/Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA, The Netherlands
    J Dent Res 80:1436-40. 2001
    ..plaque non-destructively with a vitality staining technique to assess the immediate bactericidal effect of chlorhexidine (CHX) on biofilm. Three 200-microm-wide grooves were cut into bovine dentin discs for plaque accumulation...
  23. ncbi Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection
    Paul D R Johnson
    Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia
    Med J Aust 183:509-14. 2005
    ..To assess the effect of a multifaceted hand hygiene culture-change program on health care worker behaviour, and to reduce the burden of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infections...
  24. ncbi Antimicrobial effect and pH of chlorhexidine gel and calcium hydroxide alone and associated with other materials
    Francisco Jose de Souza-Filho
    Endodontic Area, Department of Restorative Dentistry, School of Dentistry of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    Braz Dent J 19:28-33. 2008
    The purposes of this study were to evaluate the effectiveness of 2% chlorhexidine (CHX) gluconate gel, calcium hydroxide [Ca(OH)2] and their combination with iodoform and zinc oxide powder as intracanal medications against select ..
  25. ncbi In vitro assessment of the effectiveness of chlorhexidine gel and calcium hydroxide paste with chlorhexidine against Enterococcus faecalis and Candida albicans
    Ertugrul Ercan
    Department of Operative Dentistry, School of Dentistry, University of Kirikkale, Kirikkale, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e27-31. 2006
    The purpose of this study was to compare the effectiveness of various medicaments, including Ca(OH)2/2% chlorhexidine, 2% chlorhexidine gel, and Ca(OH)2 alone, against Enterococcus faecalis and Candid albicans in vitro.
  26. ncbi Efficacy of chlorhexidine- and calcium hydroxide-containing medicaments against Enterococcus faecalis in vitro
    Bettina Basrani
    Dalhousie University, Endodonic Division, Department of Dental Clinical Sciences, Halifax, Nova Scotia, Canada
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:618-24. 2003
    We sought to assess the efficacy of chlorhexidine (CHX) and calcium hydroxide, Ca(OH)(2), against Enterococcus faecalis in vitro.
  27. pmc Substantivity of chlorhexidine to human dentin
    Marcela R Carrilho
    GEO UNIBAN, Health Institute, Bandeirante University of Sao Paulo, Sao Paulo, Brazil
    Dent Mater 26:779-85. 2010
    ..To better comprehend the role of CHX in the preservation of resin-dentin bonds, this study investigated the substantivity of CHX to human dentin...
  28. ncbi Does microbial resistance or adaptation to biocides create a hazard in infection prevention and control?
    B Meyer
    Ecolab Deutschland GmbH, Dusseldorf, Germany
    J Hosp Infect 76:200-5. 2010
    ..We conclude that the current risks to healthcare delivery caused by resistance related to biocides are low, provided that biocides are used under appropriate conditions. The need for further research is addressed...
  29. ncbi The effect of adjunctive chlorhexidine mouthrinse on clinical parameters and gingival crevicular fluid cytokine levels in untreated plaque-associated gingivitis
    O Turkoglu
    School of Dentistry, Department of Periodontology, Ege University, Izmir, Turkey
    Inflamm Res 58:277-83. 2009
    To examine the effectiveness of chlorhexidine mouthrinse (CHX) in addition to daily plaque control on gingival inflammation.
  30. ncbi Evaluation of chlorhexidine substantivity on salivary flora by epifluorescence microscopy
    I Tomas
    School of Medicine and Dentistry, Santiago de Compostela University, Santiago de Compostela, Spain
    Oral Dis 15:428-33. 2009
    To evaluate the in vivo antimicrobial activity of chlorhexidine (CHX) in saliva 7 h after its application using an epifluorescence microscopy technique.
  31. ncbi The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: A systematic review of the literature
    Luciana Gazaniga Maia Ribeiro
    Department of Preventive and Social Dentistry, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    J Dent 35:359-70. 2007
    The current study undertakes a systematic review of the literature in order to assess how long different formulations (solutions, gels and varnishes) of chlorhexidine (CHX) reduce the level of mutans streptococci (MS) in the oral cavity.
  32. pmc Antimicrobial effect of alexidine and chlorhexidine against Enterococcus faecalis infection
    Hyun Shik Kim
    Department of Conservative Dentistry, Dental Research Institute and BK21 Program, Seoul National University Dental Hospital, Seoul National University School of Dentistry, Seoul, Korea
    Int J Oral Sci 5:26-31. 2013
    ..study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than chlorhexidine. The aim of this study was to compare the antimicrobial activity of 1% alexidine with that of 2% chlorhexidine ..
  33. ncbi Effects of sub-minimum inhibitory concentrations of antimicrobial agents on Streptococcus mutans biofilm formation
    Liping Dong
    Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, 145 Changle West Road, Xi an 710032, Shaanxi, China
    Int J Antimicrob Agents 39:390-5. 2012
    ..mutans biofilm formation were evaluated following treatment with 0.5× MIC of chlorhexidine (CHX), tea polyphenols and sodium fluoride (NaF), which are common anticaries agents...
  34. pmc Chlorhexidine body washing to control antimicrobial-resistant bacteria in intensive care units: a systematic review
    Lennie P G Derde
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Intensive Care Med 38:931-9. 2012
    ..b>Chlorhexidine body washing (CHG-BW) has been proposed as a measure to limit the spread of AMRB...
  35. ncbi The effects of sodium hypochlorite (5.25%), Chlorhexidine (2%), and Glyde File Prep on the bond strength of MTA-dentin
    Ping Yan
    Department of Endodontics, School of Stomatology, Wuhan University, Luoyu Road 237, Wuhan City, China 430079
    J Endod 32:58-60. 2006
    The purpose of this study was to evaluate the effects of sodium hypochlorite (5.25%), chlorhexidine (2%), and Glyde File Prep on the bond strengths of MTA-dentin in vitro...
  36. ncbi Antimicrobial substantivity over time of chlorhexidine and cetrimide
    Pilar Baca
    Department of Preventive Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Endod 38:927-30. 2012
    ..The aim of the present study was to evaluate the antimicrobial substantivity against Enterococcus faecalis of a dentin-volumetric unit exposed for 1 minute to chlorhexidine (CHX) and cetrimide (CTR).
  37. ncbi Comparison of 5.25% sodium hypochlorite, MTAD, and 2% chlorhexidine in the rapid disinfection of polycaprolactone-based root canal filling material
    Mathew J Royal
    Department of Endodontics, College of Dentistry, University of Iowa, Iowa City, Iowa, USA
    J Endod 33:42-4. 2007
    The purpose of this investigation was to compare the effectiveness of 5.25% sodium hypochlorite, MTAD, and 2% chlorhexidine in the rapid disinfection of Resilon pellets...
  38. ncbi A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease
    Isaac C Yue
    Harvard School of Dental Medicine, Boston, MA, USA
    Biomaterials 25:3743-50. 2004
    ..Microparticles of poly(dl-lactic-co-glycolic acid) (PLGA) containing chlorhexidine (Chx) free base, chlorhexidine digluconate (Chx-Dg) and their association or inclusion complex with methylated-..
  39. ncbi The anti-microbial effect against enterococcus faecalis and the compressive strength of two types of mineral trioxide aggregate mixed with sterile water or 2% chlorhexidine liquid
    Dennis M Holt
    Department of Endodontics, Wilford Hall Medical Center, Lackland AFB, Texas 78236 5346, USA
    J Endod 33:844-7. 2007
    ..effect of gray and tooth-colored mineral trioxide aggregate (MTA) when mixed with sterile water or 2% chlorhexidine. Second, to compare the compressive strengths of the MTA/chlorhexidine versus MTA/sterile water samples...
  40. ncbi Disinfection of gutta-percha cones with chlorhexidine and sodium hypochlorite
    Brenda Paula Figueiredo de Almeida Gomes
    Department of Restorative Dentistry, State University of Campinas, Piracicaba, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:512-7. 2005
    To evaluate the effectiveness of chlorhexidine (CHX) or sodium hypochlorite (NaOCl) in disinfecting gutta-percha cones, to verify contamination of gutta-percha cones in their boxes, and to identify microorganisms after intentional ..
  41. ncbi The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial
    Michael W Climo
    Hospital Epidemiologist MWC, Hunter Holmes McGuire Veteran Affairs Medical Center, Richmond, VA, USA
    Crit Care Med 37:1858-65. 2009
    ..Novel strategies are needed to reduce transmission. This study sought to determine if the use of daily chlorhexidine bathing would decrease the incidence of colonization and bloodstream infections (BSI) because of methicillin-..
  42. ncbi In vitro assessment of the antimicrobial action and the mechanical ability of chlorhexidine gel as an endodontic irrigant
    C C Ferraz
    School of Dentistry of Piracicaba, University of Campinas, Brazil
    J Endod 27:452-5. 2001
    The objective of this study was to assess the chlorhexidine gluconate gel as an endodontic irrigant. First the ability of chlorhexidine gel to disinfect root canals contaminated in vitro with Enterococcus faecalis was investigated...
  43. ncbi Evaluation of the effect of two chlorhexidine preparations on biofilm bacteria in vitro: a three-dimensional quantitative analysis
    Ya Shen
    Division of Endodontics, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, Canada
    J Endod 35:981-5. 2009
    ..The purpose of this study was to develop a biofilm model that closely mimicked in vivo biofilm and to determine its susceptibility to endodontic antimicrobial irrigants by three-dimensional quantitative analysis...
  44. ncbi Chlorhexidine-impregnated dressing for prevention of colonization of central venous catheters in infants and children: a randomized controlled study
    Itzhak Levy
    Department of Pediatric Infectious Diseases, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
    Pediatr Infect Dis J 24:676-9. 2005
    ..The aim of this study was to evaluate the effectiveness and safety of a chlorhexidine gluconate-impregnated dressing for the reduction of central venous catheter (CVC) colonization and CVC-..
  45. ncbi Chlorhexidine gluconate in endodontics: an update review
    Zahed Mohamadi Kanisavaran
    Int Dent J 58:247-57. 2008
    ..In order to reduce or eliminate bacteria, various irrigation solutions have been used during treatment. Chlorhexidine is a cationic molecule which can be used during treatment. It has a wide range antimicrobial activity...
  46. ncbi Chlorhexidine: expanding the armamentarium for infection control and prevention
    Aaron M Milstone
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 46:274-81. 2008
    ..Limited antimicrobial agents and a dry drug pipeline make novel prevention efforts critical. Chlorhexidine, an antiseptic solution that has been used worldwide since the 1950s, is a safe and effective product with ..
  47. pmc Analysis of the effects of chlorhexidine on oral biofilm vitality and structure based on viability profiling and an indicator of membrane integrity
    C K Hope
    Microbiology Unit, Division of Infection and Immunity, Eastman Dental Institute for Oral Health Care Sciences, University College London, London, United Kingdom
    Antimicrob Agents Chemother 48:1461-8. 2004
    ..b>Chlorhexidine gluconate (CHX) was added to the viewing solution to achieve concentrations of 0.05 and 0...
  48. ncbi In vitro antimicrobial activity of several concentrations of sodium hypochlorite and chlorhexidine gluconate in the elimination of Enterococcus faecalis
    B P Gomes
    Endodontic Unit, School of Dentistry of Piracicaba, State University of Campinas UNICAMP, SP, Brazil
    Int Endod J 34:424-8. 2001
    ..5%, 1%, 2.5%, 4% and 5.25%) and two forms of chlorhexidine gluconate (gel and liquid) in three concentrations (0.2%, 1% and 2%) in the elimination of E. faecalis.
  49. ncbi An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses
    S Shapiro
    Institute for Oral Microbiology and General Immunology, Center for Dentistry, Oral Medicine, and Maxillofacial Surgery, University of Zurich, Switzerland
    Caries Res 36:93-100. 2002
    ..aimed at fine-tuning the model indicated that optimal correspondence between in vitro and clinical results for chlorhexidine-containing formulations were obtained at a saliva:medium ratio of 70:30 (v/v); moreover, expanding the ..
  50. ncbi Disinfection of dentinal tubules with 2% chlorhexidine, 2% metronidazole, bioactive glass when compared with calcium hydroxide as intracanal medicaments
    Jogikalmat Krithikadatta
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College, Maduravoyal, India
    J Endod 33:1473-6. 2007
    ..This study evaluates the disinfection of dentinal tubules using 2% chlorhexidine gel, 2% metronidazole gel, bioactive glass (S53P4) in comparison with calcium hydroxide...
  51. ncbi Evaluation of time required for recontamination of coronally sealed canals medicated with calcium hydroxide and chlorhexidine
    B P F A Gomes
    Department of Restorative Dentistry, Endodontic Unit, Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    Int Endod J 36:604-9. 2003
    To determine in vitro the time required for recontamination of coronally sealed canals medicated with either calcium hydroxide (CaOH2), 2% chlorhexidine gel (CG) or with a combination of both.
  52. ncbi Validation of an in vitro biofilm model of supragingival plaque
    B Guggenheim
    Institute for Oral Microbiology and General Immunology, Center for Dentistry, Oral Medicine, and Maxillofacial Surgery, University of Zurich, Switzerland
    J Dent Res 80:363-70. 2001
    ..5 hrs and 64.5 hrs. Brief exposures of biofilms to chlorhexidine or Triclosan produced losses in viability similar to those observed in vivo...
  53. ncbi Effects of endodontic irrigation solutions on mineral content of root canal dentin using ICP-AES technique
    Hale Ari
    Department of Endodontics, Selcuk University Faculty of Dentistry, Konya, Turkey
    J Endod 31:187-9. 2005
    ..The groups were treated as follows: group 1, 0.2% chlorhexidine gluconate for 15 min; group 2, 3% H2O2 for 15 min; group 3, 17% EDTA for 15 min; group 4, 5...
  54. ncbi Susceptibilities of Enterococcus faecalis biofilms to some antimicrobial medications
    K C Lima
    Department of Preventive and Social Dentistry, Faculty of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil
    J Endod 27:616-9. 2001
    ..The purpose of this study was to evaluate the effectiveness of chlorhexidine- or antibiotics-based medications in eliminating E. faecalis biofilms. One-day and three-day biofilms of E...
  55. ncbi Chlorhexidine substantivity in root canal dentin
    Sidney Rosenthal
    Department of Endodontology, University of Connecticut School of Dental Medicine, Farmington, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:488-92. 2004
    The purpose of this investigation was to evaluate the substantivity of chlorhexidine (CHX) within a root canal system and to assess how long the CHX remains antimicrobially effective.
  56. pmc Efficacy of chlorhexidine varnish for the prevention of adult caries: a randomized trial
    A S Papas
    Tufts University School of Dental Medicine, Boston, MA 02111, USA
    J Dent Res 91:150-5. 2012
    ..for developing caries (20 or more intact teeth and 2 or more lesions at screening) to test the efficacy of a chlorhexidine diacetate 10% weight per volume (w/v) dental coating (CHX)...
  57. ncbi Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry
    Satoshi Imazato
    Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Dent Mater J 28:11-9. 2009
    ..restorative treatment, the approach to provide antibacterial activity has been attempted by addition of chlorhexidine. Incorporation of 1% chlorhexidine diacetate was found to be optimal to give appropriate antibacterial and ..
  58. ncbi Differences in efficacy of two commercial 0.2% chlorhexidine mouthrinse solutions: a 4-day plaque re-growth study
    Nicole B Arweiler
    Department of Operative Dentistry and Periodontology, Dental School and Hospital, Albert Ludwigs University, Freiburg, Germany
    J Clin Periodontol 33:334-9. 2006
    The purpose of this clinical cross-over study was to examine the antibacterial and plaque-inhibiting properties of two chlorhexidine solutions compared with a negative control.
  59. ncbi Chlorhexidine gluconate attenuates the ability of lipoteichoic acid from Enterococcus faecalis to stimulate toll-like receptor 2
    Jin Kyung Lee
    Department of Conservative Dentistry and Dental Research Institute and BK21 Program, School of Dentistry, Seoul National University, Seoul, Republic of Korea
    J Endod 35:212-5. 2009
    b>Chlorhexidine gluconate (CHX) has been widely used as a canal irrigant or an intracanal medicament on account of its antibacterial substantivity...
  60. ncbi Interaction between sodium hypochlorite and chlorhexidine gluconate
    Bettina R Basrani
    Department of Endodontics University of Toronto, Toronto, Ontario, Canada
    J Endod 33:966-9. 2007
    The combination of sodium hypochlorite (NaOCl) and chlorhexidine (CHX) results in the formation of a precipitate. The aim of this study was to determine the minimum concentration of NaOCl required to form a precipitate with 2.0% CHX...
  61. ncbi Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review
    Danielle A C Van Strydonck
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands
    J Clin Periodontol 39:1042-55. 2012
    To systematically evaluate the efficacy of chlorhexidine (CHX) mouthrinses on plaque, gingival inflammation and staining in gingivitis patients.
  62. pmc Direct visualization of spatial and temporal patterns of antimicrobial action within model oral biofilms
    Shoji Takenaka
    Center for Biofilm Engineering, Montana State University Bozeman, Bozeman, MT 59717 3980, USA
    Appl Environ Microbiol 74:1869-75. 2008
    ..When an antimicrobial mouthrinse containing chlorhexidine digluconate was administered, a gradual loss of green fluorescence was observed that began at the periphery of ..
  63. ncbi Long-term antibacterial effects and physical properties of a chlorhexidine-containing glass ionomer cement
    L Sebnem Türkün
    Department of Restorative Dentistry and Endodontics, Ege University, School of Dentistry, Izmir, Turkey
    J Esthet Restor Dent 20:29-44; discussion 45. 2008
    ..For restorative techniques used in these regions, an antibacterial self-adherent glass ionomer material would contribute considerably...
  64. ncbi Longitudinal analysis of chlorhexidine susceptibilities of nosocomial methicillin-resistant Staphylococcus aureus isolates at a teaching hospital in Taiwan
    Jann Tay Wang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Antimicrob Chemother 62:514-7. 2008
    b>Chlorhexidine has been widely used for hand hygiene to prevent transmission of nosocomial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA)...
  65. ncbi Antimicrobial activity and local release characteristics of chlorhexidine diacetate loaded within the dental copolymer matrix, ethylene vinyl acetate
    Roland R Arnold
    Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7450, USA
    J Biomed Mater Res B Appl Biomater 86:506-13. 2008
    ..Test samples of ethylene vinyl acetate copolymer (EVA) containing chlorhexidine diacetate (CDA) showed desirable antimicrobial properties and steady, slow release into aqueous and other ..
  66. ncbi The effect of chlorhexidine as an endodontic disinfectant
    Ahmad Zamany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:578-81. 2003
    The purpose of this study was to establish whether addition of a 2% chlorhexidine rinse to a conventional treatment protocol enhances the rate of the successful disinfection of the root canal system in vivo.
  67. ncbi Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model
    Shunsuke Takahashi
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi Minami ku, Hiroshima, Japan
    Nephron Exp Nephrol 112:e59-69. 2009
    ..We therefore examined the effects of mizoribine in an experimental model of peritoneal fibrosis...
  68. ncbi Enterococcus faecalis biofilms eradication by root canal irrigants
    María Teresa Arias-Moliz
    Department of Microbiology, School of Dentistry, University of Granada, Granada, Spain
    J Endod 35:711-4. 2009
    ..study was to evaluate the minimal biofilm eradication concentration (MBEC) of sodium hypochlorite (NaOCl), chlorhexidine (CHX), EDTA, and citric and phosphoric acids after 1, 5, and 10 minutes of exposure to biofilms of ..
  69. pmc Cloning of a cation efflux pump gene associated with chlorhexidine resistance in Klebsiella pneumoniae
    Chi Tai Fang
    Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Antimicrob Agents Chemother 46:2024-8. 2002
    Expression libraries of a chlorhexidine-resistant Klebsiella pneumoniae strain were constructed and transformed into Escherichia coli XLOLR. Twenty chlorhexidine-resistant transformants were obtained after selection...
  70. ncbi Antibacterial activity, surface roughness, flexural strength, and solubility of conventional luting cements containing chlorhexidine diacetate/cetrimide mixtures
    Fatih Mehmet Korkmaz
    Department of Prosthodontics, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey
    J Prosthet Dent 110:107-15. 2013
    ..The failure of fixed dental restorations is commonly associated with caries. The use of conventional luting cements containing antibacterial agents may overcome this problem...
  71. ncbi Chlorhexidine-releasing methacrylate dental composite materials
    Danny Leung
    Eastman Dental Institute, University College London, UK
    Biomaterials 26:7145-53. 2005
    ..The monomers contained 40-100 wt% of a 10 wt% chlorhexidine diacetate (CHXA) in hydroxyethylmethacrylate (HEMA) solution and 60-0 wt% of a 50/50 mix of urethane ..
  72. ncbi Effect of phenotypic switching on the biological properties and susceptibility to chlorhexidine in Candida krusei ATCC 14243
    Mohd Hafiz Arzmi
    Department of Oral Biology, University of Malaya, Kuala Lumpur, Malaysia
    FEMS Yeast Res 12:351-8. 2012
    ..14243 and to determine its effect on the biological properties, adherence capacity and susceptibility towards chlorhexidine digluconate (CHX). To induce switched generations C...
  73. ncbi In vitro evaluation of the antimicrobial activity of a castor oil-based irrigant
    M R Leonardo
    Department of Endodontics, School of Dentistry of Araraquara, , UNESP, Brazil
    J Endod 27:717-9. 2001
    The antimicrobial activity of irrigating solutions--Endoquil (castor oil detergent), 2% chlorhexidine gluconate solution, and 0...
  74. ncbi Antimicrobial analysis of chlorhexidine gel and intracanal medicaments against microorganisms inoculated in root canals
    M C Valera
    Department of Restorative Dentistry, Sao Paulo State University UNESP, Sao Jose dos Campos, Sao Paulo, Brazil
    Minerva Stomatol 59:415-21. 2010
    The aim of this paper was to evaluate the antimicrobial activity of 2% chlorhexidine gel (CLX) associated with various intracanal medicaments against Candida albicans and Enterococcus faecalis inoculated in root canals.
  75. ncbi Action of propolis and medications against Escherichia coli and endotoxin in root canals
    Marcia Carneiro Valera
    Department of Restorative Dentistry, School of Dentistry of São José dos Campos, Sao Paulo State University, Sao Jose dos Campos, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110:e70-4. 2010
    ..divided into groups according to the type of intracanal medication: Ca(OH)(2), polymyxin B, or Ca(OH)(2) + 2% chlorhexidine gel. In the control group, saline solution was used without application of intracanal medication...
  76. ncbi Comparative in vitro study among the effects of different laser and LED irradiation protocols and conventional chlorhexidine treatment for deactivation of bacterial lipopolysaccharide adherent to titanium surface
    Marco Giannelli
    Odontostomatologic Laser Therapy Center, Florence, Italy
    Photomed Laser Surg 29:573-80. 2011
    ..nm), used in photodynamic (PD) mode together with the photoactivated agent methylene blue; and 3) chlorhexidine, used as reference drug, to reduce the activation of macrophages by lipopolysaccharide (LPS), a major pro-..
  77. ncbi The antimicrobial activity of a dentin conditioner combined with antibacterial agents
    Michael G Botelho
    Oral Rehabilitation University of Hong Kong, Prince Philip Dental Hospital, Hong Kong SAR, China
    Oper Dent 30:75-82. 2005
    ..Antibacterial agents--chlorhexidine hydrochloride, cetylpyridinium chloride, cetrimide, benzaIkonium chloride and sodium hypochlorite, were added ..
  78. ncbi An in vitro synergetic evaluation of the use of nisin and sodium fluoride or chlorhexidine against Streptococcus mutans
    Zhongchun Tong
    Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Peptides 32:2021-6. 2011
    The objective of this study is to investigate the synergetic action between nisin and sodium fluoride or chlorhexidine against Streptococcus mutans, a primary cariogenic pathogen. In the antibacterial assay, a synergetic effect on S...
  79. ncbi Substantive antimicrobial activity in chlorhexidine-treated human root dentin
    Bettina Basrani
    Department of Endodontics, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:240-5. 2002
    ..The aim of this in vitro study was to assess the substantive antimicrobial activity of different medicaments in human root dentin...
  80. ncbi Sustained ex vivo skin antiseptic activity of chlorhexidine in poly(epsilon-caprolactone) nanocapsule encapsulated form and as a digluconate
    Hassan Lboutounne
    Laboratoire de Pharmacotechnie, Biopharmacie et Cosmétologie, Institut des Sciences Pharmaceutiques et Biologiques, Universite Claude Bernard Lyon I, 8, avenue Rockefeller, F 69373, Lyon, Cedex 08, France
    J Control Release 82:319-34. 2002
    In this work, the sustained bactericidal activity of chlorhexidine base loaded poly(epsilon-caprolactone), PCL, nanocapsules against Staphylococcus epidermidis inoculated onto porcine ear skin was investigated...
  81. ncbi The effect of chlorhexidine varnish on root caries: a systematic review
    D E Slot
    Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam, The Netherlands
    Caries Res 45:162-73. 2011
    The aim of this study was to systematically review the present literature on the effect of chlorhexidine varnish (CHX-V) on root caries.
  82. ncbi Controlled release of chlorhexidine from amorphous microporous silica
    E Verraedt
    Centre of Surface Chemistry and Catalysis, Katholieke Universiteit Leuven, Kasteelpark Arenberg 23, B 3001 Heverlee, Belgium
    J Control Release 142:47-52. 2010
    A new system for the controlled release of the antiseptic chlorhexidine is presented. Amorphous microporous silica (AMS) excipient material was synthesized via an acid catalyzed sol-gel method and shaped as powder or coating...
  83. ncbi In vitro evaluation of the antimicrobial activity of chlorhexidine and sodium hypochlorite
    Morgana Eli Vianna
    Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas, SP, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:79-84. 2004
    The aim of this study was to investigate in vitro the antimicrobial activity of 0.2%, 1%, and 2% chlorhexidine gluconate (CHX gel and CHX liquid), against endodontic pathogens and compare the results with the ones achieved by 0.5%, 1%, 2...
  84. ncbi Implementation of chlorhexidine gluconate for central venous catheter site care at Siriraj Hospital, Bangkok, Thailand
    Bancherd Balamongkhon
    Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Am J Infect Control 35:585-8. 2007
    A meta-analysis and cost-effectiveness analysis of randomized controlled trials comparing chlorhexidine gluconate with povidone-iodine solutions for venous catheter site care found that the use of chlorhexidine gluconate significantly ..
  85. doi Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit
    M P Romero-Gómez
    Infect Control Hosp Epidemiol 29:377-8. 2008
  86. pmc Effect of dentin etching and chlorhexidine application on metalloproteinase-mediated collagen degradation
    Raquel Osorio
    Department of Dental Materials, School of Dentistry, University of Granada, Granada, Spain
    Eur J Oral Sci 119:79-85. 2011
    ..This study evaluated whether collagen degradation can be prevented by chlorhexidine digluconate (CHX) after different dentin demineralization procedures...
  87. ncbi Disinfection of artificially contaminated Resilon cones with chlorhexidine and sodium hypochlorite at different time exposures
    Aysin Dumani
    Department of Conservative Dentistry and Endodontics, University of Cukurova, Faculty of Dentistry, Adana, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e82-5. 2007
    The aim of this study was to evaluate the efficiency of chlorhexidine (CHX) and sodium hypochlorite (NaOCl) solutions on Resilon cones that were artificially contaminated with microbial samples of Enterococcus faecalis or Candida ..
  88. ncbi Efficacy of calcium hydroxide: chlorhexidine paste as an intracanal medication in bovine dentin
    Matthew D Evans
    Oregon Health and Science University, Portland 97201, USA
    J Endod 29:338-9. 2003
    ..was to evaluate the antibacterial efficacy of an intracanal medication composed of calcium hydroxide with 2% chlorhexidine. Dentin from 24 bovine incisors was used...
  89. ncbi A 0.05% cetyl pyridinium chloride/0.05% chlorhexidine mouth rinse during maintenance phase after initial periodontal therapy
    Marc Quirynen
    Department of Periodontology, Oral Pathology and Maxillo Facial Surgery, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium
    J Clin Periodontol 32:390-400. 2005
    b>Chlorhexidine (CHX) mouth rinse/spray can still be considered the gold standard in the chemical prevention of plaque formation and development of gingivitis...
  90. ncbi Efficacy and limitation of a chlorhexidine-based decolonization strategy in preventing transmission of methicillin-resistant Staphylococcus aureus in an intensive care unit
    Rahul Batra
    Directorate of Infection, Guy s and St Thomas National Health Service Foundation Trust, London, UK
    Clin Infect Dis 50:210-7. 2010
    Surface-active antiseptics, such as chlorhexidine, are increasingly being used as part of intervention programs to prevent methicillin-resistant Staphylococcus aureus (MRSA) transmission, despite limited evidence and potential for ..
  91. ncbi Removal efficacy of various calcium hydroxide/chlorhexidine medicaments from the root canal
    T Lambrianidis
    Department of Endodontology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int Endod J 39:55-61. 2006
    To compare the efficiency of removing calcium hydroxide [Ca(OH)(2)]/chlorhexidine (CHX) (gel), Ca(OH)(2)/CHX (solution) and Ca(OH)(2)/saline pastes with the use of instrumentation and irrigation with sodium hypochlorite and ethylene ..
  92. ncbi The efficacy of daily bathing with chlorhexidine for reducing healthcare-associated bloodstream infections: a meta-analysis
    John C O'Horo
    Department of Graduate Medical Education, Aurora Healthcare Metro, Milwaukee, WI 53705, USA
    Infect Control Hosp Epidemiol 33:257-67. 2012
    Systematic review and meta-analysis of randomized controlled trials and quasi-experimental studies to assess the efficacy of daily bathing with chlorhexidine (CHG) for prevention of healthcare-associated bloodstream infections (BSIs).
  93. ncbi The adjunctive use of a controlled-release chlorhexidine chip following treatment with a new ultrasonic device in supportive periodontal therapy: a prospective, controlled clinical study
    Adrian Kasaj
    Department of Operative Dentistry, Johannes Gutenberg University, Mainz, Germany
    Int J Dent Hyg 5:225-31. 2007
    ..randomised, split-mouth, controlled clinical trial was to evaluate the effectiveness of a controlled-release chlorhexidine chip (CHX chip) as an adjunctive therapy to scaling and root planing (SRP) with a newly developed ultrasonic ..
  94. ncbi Antioxidant and pro-oxidant properties of chlorhexidine and its interaction with calcium hydroxide solutions
    S Y Yeung
    Department of Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan
    Int Endod J 40:837-44. 2007
    To evaluate the antioxidant and pro-oxidant properties of chlorhexidine (CHX).
  95. ncbi Plaque inhibition of two commercially available chlorhexidine mouthrinses
    D A C Van Strydonck
    Department of Periodontology, Academic Centre for Dentistry, Amsterdam, The Netherlands
    J Clin Periodontol 32:305-9. 2005
    b>Chlorhexidine (CHX) 0.2% solution is still "the leading oral antiseptic" for controlling gingivitis. Side effects, however, limit the acceptability to users and the long-term employment of a 0.2% CHX antiseptic in preventive dentistry...
  96. ncbi In vitro studies on controlled-release cellulose acetate films for local delivery of chlorhexidine, indomethacin, and meloxicam
    Emel Oyku Cetin
    Department of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, Ege University, Izmir, Turkey
    J Clin Periodontol 31:1117-21. 2004
    ..The aim of the present study was to examine the in vitro release profile of chlorhexidine gluconate, indomethacin, and meloxicam from cellulose acetate films.
  97. ncbi Killing of Enterococcus faecalis by MTAD and chlorhexidine digluconate with or without cetrimide in the presence or absence of dentine powder or BSA
    Isabelle Portenier
    Department of Endodontics, Dental Faculty, University of Oslo, Oslo, Norway
    J Endod 32:138-41. 2006
    ..The aim of this study was to investigate the antibacterial activity of MTAD and chlorhexidine towards two strains of Enterococcus faecalis and the inhibitory effects of dentine and bovine serum albumin on ..
  98. ncbi Additive antimicrobial activity of calcium hydroxide and chlorhexidine on common endodontic bacterial pathogens
    Andreas Podbielski
    Department of Medical Microbiology and Hospital Hygiene, University Hospital Rostock, Germany
    J Endod 29:340-5. 2003
    ..ZnO) points alone; (c) Ca(OH)2 suspension combined with ZnO points; (d) Ca(OH)2 suspension combined with ZnO/chlorhexidine points; and (e) Ca(OH)2 points combined with ZnO/chlorhexidine points...
  99. ncbi Local delivery of chlorhexidine gluconate in patients with aggressive periodontitis
    Fabio de Freitas Duarte
    Department of Periodontology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    J Int Acad Periodontol 10:31-5. 2008
    ..aim of this randomized, controlled, single-blinded trial was to evaluate the effectiveness of a biodegradable chlorhexidine chip as an adjunctive therapy to scaling and root planing...
  100. pmc Controlled release of chlorhexidine from UDMA-TEGDMA resin
    K J Anusavice
    Department of Dental Biomaterials, College of Dentistry, University of Florida, PO Box 100446, 1600 SW Archer Road, Gainesville, FL 32610 0446, USA
    J Dent Res 85:950-4. 2006
    b>Chlorhexidine salts are available in various formulations for dental applications...
  101. ncbi Antibacterial efficacy of a new chlorhexidine slow release device to disinfect dentinal tubules
    Shaul Lin
    Department of Endodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel
    J Endod 29:416-8. 2003
    ..In nine specimens, 5% chlorhexidine was placed in a slow-release device (Activ Point) for 7 days, in another nine irrigation with 10 ml of 0...

Research Grants65

  1. CHLORHEXIDINE IRRIGATION TO PREVENT INFECTION
    Dwight Rouse; Fiscal Year: 2001
    ..Ideally the agent would be commercially available and inexpensive. The widely used medical disinfectant chlorhexidine satisfies these requirements...
  2. PREVENT TRANSMIS OF MUTANS STREPTOC FR MOTHER TO CHILD
    Walter Bretz; Fiscal Year: 2004
    ..program which may include restorative procedures, topical fluorides, the use of xylitol chewing gum, and chlorhexidine varnishes; 2) to determine whether this intervention reduces or delays the acquisition of MS in the infants ..
  3. Biofilm matrix-degrading enzymes for the treatment and prevention of S. aureus-as
    Jeffrey B Kaplan; Fiscal Year: 2013
    ..Topical biocides will include povidone iodine and chlorhexidine gluconate...
  4. Chicago Prevention and Intervention Epicenter (Chicago PIE)
    ROBERT ALAN WEINSTEIN; Fiscal Year: 2013
    ..long-term care facilities that will include enhanced surveillance and communication and patient cleansing with chlorhexidine to decrease MDRO risk in Chicago. Successful projects can inform MDRO control in other geographic areas...
  5. Waterless hand sanitizer for diarrhea prevention in a humanitarian emergency
    Pavani Kalluri Ram; Fiscal Year: 2013
    ..Many waterless sanitizers contain alcohol but alternative options, such as chlorhexidine gel, have similar antimicrobial efficacy and may be more acceptable to some populations with religious or ..
  6. Project CLEAR - Changing Lives by Eradicating Antibiotic Resistance
    Susan S Huang; Fiscal Year: 2012
    ..We hypothesize that serial decolonization of MRSA carriers with nasal mupirocin, oral chlorhexidine rinses, and chlorhexidine body wash will significantly reduce inpatient and outpatient MRSA infections in the ..
  7. Planning Grant for Parasitic Ulcer Treatment Trial
    Jeremy David Keenan; Fiscal Year: 2013
    ..2) To determine whether patients randomized to single agent therapy for acanthamoeba keratitis with topical chlorhexidine have similar microbial cure times compared to those randomized to multiple agent therapy with topical ..
  8. Decreasing Bioburden to Reduce Healthcare-Associated Infections and Readmissions
    Susan S Huang; Fiscal Year: 2013
    ..Studies in intensive care units (ICUs) indicate that decolonization of patients'skin with chlorhexidine, and nares with mupirocin can prevent many HAIs...
  9. Reasons for poor durability of resin-dentin bonds
    David H Pashley; Fiscal Year: 2013
    ..The recent discovery that chlorhexidine (CHX), a potent antimicrobial agent, also has potent anti-MMP -2, -8 and -9 activity (Gendron et al...
  10. Epicenters III: Translational Research to Prevent Healthcare Associated Infection
    Richard Platt; Fiscal Year: 2013
    ..Two topics deal with complications of ventilator care: 3) We will explore the potential utility of chlorhexidine for gastric decontamination to reduce the incidence of ventilator-associated pneumonia and other nosocomial ..
  11. Staphylococcus aureus resistance to topical antimicrobial agents in children
    JONATHON CHASE MCNEIL; Fiscal Year: 2013
    ..In addition, we further hypothesize that chlorhexidine may serve as a useful alternative in cases of mupirocin resistance based on diverging mechanisms of action...
  12. A Randomized Clinical Trial to Prevent Recurrent CA-MRASA Infection
    Loren Miller; Fiscal Year: 2009
    ..For this clinical trial, all subjects will be randomized in a 2 x 2 design to test: 1) chlorhexidine body washes plus nasal mupirocin ointment vs...
  13. A Randomized Controlled Trial to Reduce Pneumonia in Nursing Home Residents
    VINCENT JAMES QUAGLIARELLO; Fiscal Year: 2013
    ..The multicomponent intervention will consist of manual brushing of teeth and gums (twice per day) plus 0.12% chlorhexidine oral rinse (twice per day) plus upright feeding positioning during and after meals...
  14. MRSA in Children: Epidemiology, Pathogenesis, and Prevention
    Aaron M Milstone; Fiscal Year: 2012
    ..in children colonized with different MRSA strains;and 3) assess the efficacy of bathing patients daily with chlorhexidine as a feasible strategy to reduce MRSA transmission...
  15. Cellulose-Based Strips for Human Taste Evaluation
    Lloyd Hastings; Fiscal Year: 2010
    ..Test sensitivity in detecting gustatory deficits will be examined by administering taste blockers, e.g., chlorhexidine, to the subjects before testing...
  16. Prevention of Adult Caries Study (PACS) Data Coordinating Center
    WILLIAM MARION VOLLMER; Fiscal Year: 2010
    ..PACS primary aims are 1) to test the hypothesis that chlorhexidine (10% w/v) dental coating, compared to a placebo coating, reduces adult caries increment in at-risk adults, and ..
  17. Oral Colonization of Aggregatibacter in Primates
    Daniel H Fine; Fiscal Year: 2012
    ..Before placement, monkeys will receive scaling and prophylaxis plus chlorhexidine treatment...
  18. Rechargeable Long-term Anticandidal Denture Materials
    Chih ko Yeh; Fiscal Year: 2013
    ..as a "rechargeable battery" to bind and then slowly release cationic antifungal drugs such as miconazole and chlorhexidine gluconate for a long period of time (weeks to months)...
  19. Rechargeable Infection-responsive Anticandidal Denture Materials
    Chih ko Yeh; Fiscal Year: 2013
    ..Antifungal drugs such as miconazole and chlorhexidine digluconate can be charged into the new denture materials and slowly released for a prolonged period of time (..
  20. Small Molecules to Enhance Bacterial Susceptibility to Antiseptics
    ANGELA MARIE POLLARD; Fiscal Year: 2012
    ..2-AI molecules have been synthetically optimized to enhance the efficacy of microbicidal products, including chlorhexidine gluconate (CHG), which is the most widely-used active ingredient in pre-operative antiseptics...
  21. Analysis for Incomplete Data in Oral Health/Ventilator-Associated Pneumonia Study
    Jihnhee Yu; Fiscal Year: 2012
    ..A total of 175 patients in an intensive care unit (ICU) were treated with chlorhexidine oral rinse once or twice per day or with a placebo control, and followed until they were discharged...
  22. An evaluation of a multi-modal network to spread an enhanced Surgical Site Infect
    DONALD ALAN GOLDMANN; Fiscal Year: 2010
    ..has identified three interventions that substantially reduce SSIs: preoperative bathing or showering with chlorhexidine;preoperative nasal screening for Staphylococcus aureus carriage followed by decolonization of S...
  23. Impact of chlorhexidine bathing on reducing infections in children with cancer
    Danielle M Zerr; Fiscal Year: 2012
    ..b>Chlorhexidine gluconate (CHG) bathing has been shown to reduce the incidence of CLABSI and acquisition of MDRO (colonization ..
  24. Prevention of Adult Caries Study (PACS) Tuba City Clinical Center
    Gerardo Maupome; Fiscal Year: 2010
    ..This study is designed to evaluate the efficacy of a topical, temporary, 10% w/v chlorhexidine dental coating in reducing caries increment in at-risk adult dental patients...
  25. Prevention of Adult Caries (PACS) - Tufts Clinical Center
    Athena Papas; Fiscal Year: 2009
    ..This study is designed to evaluate the efficacy of a topical, temporary, 10% w/v chlorhexidine dental coating in reducing caries increment in at-risk adult dental patients...
  26. Metagenomic Studies of MRSA Colonization
    Mary Claire Roghmann; Fiscal Year: 2013
    ..the microbial communities at baseline and after a decolonization regimen of intranasal mupirocin and topical chlorhexidine within individuals in both populations...
  27. A DRUG RELEASING URINARY CATHETER
    Robert Whalen; Fiscal Year: 2000
    ..urinary catheter manufactured from a silicone rubber material which is loaded with the antimicrobial agent chlorhexidine gluconate (CHG)...
  28. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..colonization when compared usual to oral care plus swabbing with a placebo solution or the antimicrobial agent chlorhexidine. Seventy-five patients expected to be on a ventilator for more than 48 hours will be recruited for this study...
  29. Continuous Biofilm Disrupting Materials
    SHANTHA SARANGAPANI; Fiscal Year: 2009
    ..of the catheters or devices with antibiotics or antiseptics like as nano silver, silver sulfadiazine and/or chlorhexidine, antibiotics have been commercialized with limited success due to rapid release rates resulting in depletion ..
  30. Intra-oral Drug Delivery Systems for HIV/AIDS Patients
    Steven Offenbacher; Fiscal Year: 2007
    ..EVA) copolymer as a mouth guard device for sustained release of current FDA approved therapeutic agents, chlorhexidine, nystatin, ganciclovir and acyclovir, alone or in combination...
  31. Anti-Infective Central Venous Catheter
    MICHAEL VIOLANTE; Fiscal Year: 2002
    ..Another coated device on the market, using an active agent combination of silver sulfadiazine and chlorhexidine, has shown limited efficacy in clinical studies and was associated with hypersensitivity reactions in patients ..
  32. Newborn Antiseptic Washing and Neonatal Mortality-Nepal
    James Tielsch; Fiscal Year: 2005
    ..this project are focused on prevention of neonatal mortality and morbidity using a topical antiseptic agent (chlorhexidine, CHX)...
  33. Trials to Enhance Elders' Teeth/Oral Health (TEETH)
    Asuman Kiyak; Fiscal Year: 2004
    ..12% chlorhexidine solution on tooth loss in low income, community dwelling older adults...
  34. NEW SALICYLANILIDES FOR CONTROL OF ORAL DISEASE
    ROBERT COBURN; Fiscal Year: 1999
    ..One of these, a 5-acylsalicylanilide, has been shown to inhibit plaque in humans to an extent comparable to chlorhexidine, and also to reduce gingivitis in the absence of staining or adverse taste...
  35. Extracrevicular Invasion by Periodontal Pathogens
    JOEL RUDNEY; Fiscal Year: 2005
    ..patients who require aggressive treatment, by using FISH/LSCM and multiplex PCR to compare mucosal and gingival colonization before and after scaling and root planing, topical chlorhexidine, and systemic antibiotics.
  36. A DRUG RELEASING URINARY CATHETER
    Robert Whalen; Fiscal Year: 2004
    ..of a new, drug releasing urinary catheter fabricated from silicone rubber containing the antiseptic agent chlorhexidine gluconate (CHG)...
  37. Multicenter Trial of Daily Chlorhexidine Bathing to Reduce Nosocomial Infections
    Michael Climo; Fiscal Year: 2007
    ..In several pilot studies we have demonstrated that daily bathing of patients with chlorhexidine reduces the incidence of MRSA, VRE, and healthcare associated bacteremias...
  38. ANTIMICROBIAL RESISTANCE IN CANDIDA ALBICANS BIOFILMS
    Bonnie Tyler; Fiscal Year: 2001
    ..The efficacy of three antimicrobial agents, hydrogen peroxide, chlorhexidine gluconate, and fluconazole, against both biofilms and planktonic C. albicans will be measured...
  39. NON TOXIC ANTIMICROBIAL RINSE FOR ORAL BACTERIA
    Kenneth Norbury; Fiscal Year: 2000
    ..S. on prevention of tooth decay, single-tooth restoration, and the replacement of teeth. Chlorhexidine is available and is an effective antimicrobial mouth rinse but due to its side effects can only be used in ..
  40. NOVEL MEDICATED DENTAL FLOSS FOR DENTAL PROPHYLAXIS
    Mark Bowen; Fiscal Year: 1993
    ..Efforts to control intraoral flora by the use of antimicrobial agents, particularly chlorhexidine compounds, have been promising...
  41. Prevention of Adult Caries Study (PACS) - KP Portland Clinical Center
    John Snyder; Fiscal Year: 2009
    ..This study is designed to evaluate the efficacy of a topical, temporary, 10% w/v chlorhexidine dental coating in reducing caries increment in at-risk adult dental patients...
  42. Prevention of Adult Caries Study (PACS)- Dental Services of MA Clinical Center
    Benjamin White; Fiscal Year: 2009
    ..This study is designed to evaluate the efficacy of a topical, temporary, 10% w/v chlorhexidine dental coating in reducing caries increment in at-risk adult dental patients...
  43. Prevention of Adult Caries (PACS) - Tufts Administrative Center
    Athena Papas; Fiscal Year: 2009
    ..This study is designed to evaluate the efficacy of a topical, temporary, 10% w/v chlorhexidine dental coating in reducing caries increment in at-risk adult dental patients...
  44. Non-Toxic Antimicrobial Rinse for Gingivitis
    Bakul Bhatt; Fiscal Year: 2004
    ..b>Chlorhexidine is the most effective antimicrobial mouthrinse available, but due to its side effects can only be used in ..
  45. DRUG DELIVERY SYSTEM TO TREAT ORO-ESOPHAGEAL CANDIDIASIS
    GABRIEL GARAY; Fiscal Year: 1991
    ..capable of releasing over a period of 1-7 days, therapeutically effective quantities of the anti-fungal agent chlorhexidine will be developed...
  46. MEDICINE AND DENTIFRICE DISPENSING SONIC BRUSH
    KEVIN UNDERWOOD; Fiscal Year: 1999
    ..APPLICATION: This product combined with a novel antimicrobial or anti-inflammatory agent in liquid form (or chlorhexidine) could create a major new segment in the home-care dental marketplace...
  47. Incidence, risk factors, and consequences of neonatal hypothermia in Nepal
    LUKE MULLANY; Fiscal Year: 2008
    ..Examination of alternate cutoffs for defining hypothermia severity may improve design of low-cost technologies for identification and subsequent management of hypothermic infants in the community. [unreadable] [unreadable] [unreadable]..
  48. Oral Chlorhexidine effect on ICU mortality and ventilator-associated pneumonia
    Catherine Binkley; Fiscal Year: 2008
    ..Whether application of oral antimicrobial agents such as chlorhexidine reduces the risk of pneumonia in the general intensive care unit patient population remains controversial...
  49. Guided Pocket Recolonization (GPR) in Periodontitis
    Marc Quirynen; Fiscal Year: 2004
    ..Clinical data will be collected after 2, 4, 6, 8 and 12 weeks. The results should indicate the possible role for commensal organisms in periodontal disease and subgingival biofilm formation. ..
  50. Chlorhexidine and Pneumonia in Nursing Home Residents
    Catherine Binkley; Fiscal Year: 2008
    ..will involve the implementation of a pilot randomized, placebo controlled clinical trial of the effects of chlorhexidine oral spray in reducing pneumonia in dependent nursing home patients...
  51. Effects of Natural Agents with Fluoride on Caries
    Hyun Koo; Fiscal Year: 2004
    ....
  52. CARIES MANAGEMENT BY RISK ASSESSMENT
    John Featherstone; Fiscal Year: 2001
    ..treatment without knowledge of risk status The hypothesis to be tested is that caries management (primarily chlorhexidine fluorides, sealants) and conservative restorative treatment based on caries-risk status will significantly ..
  53. Planning Grant for Xylitol Trial in Caries-Active Adults
    James Bader; Fiscal Year: 2005
    ....
  54. EFFECT OF ANTIBIOTICS ON ORAL BIOFILMS IN VIVO
    Anne Haffajee; Fiscal Year: 2001
    ..abstract_text> ..
  55. CONTROLLED-RELEASE SEALANT TO PREVENT SECONDARY CARIES
    Kenneth Anusavice; Fiscal Year: 2004
    ..of this study is to test the hypothesis that application to marginal crevices of a sealing resin that releases chlorhexidine and/or fluoride (when the pH decreases to below 6...
  56. Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized Neonates
    Aaron M Milstone; Fiscal Year: 2011
    ..This project will help to develop evidence-based strategies to prevent bloodstream infections among vulnerable infants hospitalized in the neonatal intensive care unit. ..
  57. Identification of Uncultivated and Unrecognized Pathogens of Periodontitis
    ANNE DENISE HAFFAJEE; Fiscal Year: 2010
    ..The identification of such pathogens should, over time, lead to better diagnosis of disease, optimal treatment strategies for the individual patient, new therapeutic approaches and carefully targeted approaches to prevention. ..
  58. MICROBIAL ASSOCIATIONS IN PERIODONTAL HEALTH AND DISEASE
    Anne Haffajee; Fiscal Year: 2006
    ..These data will provide a basis for understanding microbial community structure, ecological relationships and define desired microbiological end-point of therapy. ..
  59. Sedation Effects in Mechanically Ventilated Patients
    Mary Jo Grap; Fiscal Year: 2009
    ..abstract_text> ..
  60. Three Periodontal Therapies in Current & Non-Smokers
    Anne Haffajee; Fiscal Year: 2007
    ..The proposed investigation should provide a model to examine methods that could be useful in treating compromised patients whether compromised by harmful habits such as smoking, systemic disease, or genetic background. ..
  61. LASER EFFECTS ON DENTAL HARD TISSUES
    John Featherstone; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  62. Mobilization of Candida albicans Biofilms
    Peter Suci; Fiscal Year: 2007
    ..albicans biofilm communities, it will provide the basis for development of methods for screening for adjuvant agents that will inhibit dissemination of these fungal infections. [unreadable] [unreadable] [unreadable]..