sulfadoxine

Summary

Summary: A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.

Top Publications

  1. ncbi Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
    John J Aponte
    Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 374:1533-42. 2009
  2. ncbi Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis
    Kassoum Kayentao
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    JAMA 309:594-604. 2013
  3. pmc Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey data
    Anna Maria van Eijk
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet Infect Dis 11:190-207. 2011
  4. ncbi Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi
    James G Kublin
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 187:1870-5. 2003
  5. pmc Options for the delivery of intermittent preventive treatment for malaria to children: a community randomised trial
    Margaret Kweku
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 4:e7256. 2009
  6. pmc Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805 Bamako, Mali
    Malar J 9:9. 2010
  7. pmc Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial
    Amadou T Konate
    Centre National de Recherche et de Formation sur Paludisme, Ouagadougou, Burkina Faso
    PLoS Med 8:e1000408. 2011
  8. pmc Chloroquine resistance before and after its withdrawal in Kenya
    Leah Mwai
    Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
    Malar J 8:106. 2009
  9. pmc High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581
    Samwel Gesase
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    PLoS ONE 4:e4569. 2009
  10. pmc Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in Mali
    Alassane Dicko
    Malaria Research and Training Center, Departments of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, P O Box 1805, Bamako, Mali
    Malar J 7:123. 2008

Detail Information

Publications326 found, 100 shown here

  1. ncbi Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
    John J Aponte
    Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 374:1533-42. 2009
    Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.
  2. ncbi Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis
    Kassoum Kayentao
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    JAMA 309:594-604. 2013
    Intermittent preventive therapy with sulfadoxine-pyrimethamine to control malaria during pregnancy is used in 37 countries in sub-Saharan Africa, and 31 of those countries use the standard 2-dose regimen...
  3. pmc Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey data
    Anna Maria van Eijk
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet Infect Dis 11:190-207. 2011
    Insecticide-treated nets and intermittent preventive treatment with sulfadoxine-pyrimethamine are recommended for the control of malaria during pregnancy in endemic areas in Africa, but there has been no analysis of coverage data at a ..
  4. ncbi Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi
    James G Kublin
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 187:1870-5. 2003
    In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum malaria...
  5. pmc Options for the delivery of intermittent preventive treatment for malaria to children: a community randomised trial
    Margaret Kweku
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 4:e7256. 2009
    ..We have evaluated the coverage of IPTc that can be achieved by two different delivery systems in Ghana...
  6. pmc Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805 Bamako, Mali
    Malar J 9:9. 2010
    ..However, there is a fear that IPTi may result in a rapid increase of parasite resistance to SP...
  7. pmc Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial
    Amadou T Konate
    Centre National de Recherche et de Formation sur Paludisme, Ouagadougou, Burkina Faso
    PLoS Med 8:e1000408. 2011
    ....
  8. pmc Chloroquine resistance before and after its withdrawal in Kenya
    Leah Mwai
    Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
    Malar J 8:106. 2009
    ..Changes to those that occurred in the dihydrofolate reductase gene (dhfr) that confers resistance to the replacement drug, pyrimethamine/sulphadoxine were also compared...
  9. pmc High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581
    Samwel Gesase
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    PLoS ONE 4:e4569. 2009
    ..This study compared the in vivo efficacy of SP in symptomatic 6-59 month children with uncomplicated malaria and in asymptomatic 2-10 month old infants...
  10. pmc Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in Mali
    Alassane Dicko
    Malaria Research and Training Center, Departments of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, P O Box 1805, Bamako, Mali
    Malar J 7:123. 2008
    ..However in most areas malaria morbidity and mortality remain high in older children...
  11. pmc A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 3:e1934. 2008
    ..Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of their combined use...
  12. pmc Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations
    Toshihiro Mita
    Department of International Affairs and Tropical Medicine, Tokyo Women s Medical University, Japan
    J Infect Dis 204:1980-8. 2011
    ..It remains unresolved whether P. falciparum resistance to sulfadoxine, which is conferred by mutations in dihydropteroate synthase (DHPS), evolved following a similar pattern.
  13. pmc Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine
    Allen L Malisa
    Department of Biological Sciences, Faculty of Science, Sokoine University of Agriculture, SUA, PO Box 3038, Morogoro, Tanzania
    Malar J 9:190. 2010
    ..These models show that where the basis of resistance is multigenic, the effects of selection can be moderated by high recombination rates, which disrupt the associations between co-selected resistance genes...
  14. pmc Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistance
    Whitney E Harrington
    Malaria Program, Seattle Biomedical Research Institute, Seattle, Washington, USA
    Clin Infect Dis 53:224-30. 2011
    Millions of African women receive sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment during pregnancy (IPTp) to avoid poor outcomes that result from malaria...
  15. pmc Intermittent preventive treatment of malaria during pregnancy: a qualitative study of knowledge, attitudes and practices of district health managers, antenatal care staff and pregnant women in Korogwe District, North-Eastern Tanzania
    Godfrey Mubyazi
    National Institute for Medical Research, Ubwari Research Station, P O Box 81, Muheza, Tanzania
    Malar J 4:31. 2005
    ..This study assesses the knowledge, attitudes and practices of these groups in relation to malaria control with emphasis on IPTp services...
  16. ncbi Return of chloroquine antimalarial efficacy in Malawi
    Miriam K Laufer
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    N Engl J Med 355:1959-66. 2006
    In 1993, Malawi became the first country in Africa to replace chloroquine with the combination of sulfadoxine and pyrimethamine for the treatment of malaria. At that time, the clinical efficacy of chloroquine was less than 50%...
  17. ncbi Efficacy, safety, and selection of molecular markers of drug resistance by two ACTs in Mali
    Abdoulaye A Djimde
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 78:455-61. 2008
    ..trial comparing the efficacy and safety of artesunate (AS) + amodiaquine (AQ, 3 days) versus AS (3 days) + sulfadoxine-pyrimethamine (SP, single dose) versus AS monotherapy (5 days) in Southern Mali...
  18. pmc Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in pregnant women who receive preventive treatment
    W E Harrington
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:9027-32. 2009
    ..However, parasites resistant to the IPTp drug sulfadoxine-pyrimethamine (SP) have emerged worldwide, and infections with mixed resistant and susceptible parasites are ..
  19. ncbi Reaching the Abuja target for intermittent preventive treatment of malaria in pregnancy in African women: a review of progress and operational challenges
    Jenny Hill
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Trop Med Int Health 11:409-18. 2006
    ....
  20. pmc Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: a randomised controlled non-inferiority trial
    Harry Tagbor
    Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
    PLoS ONE 5:e14425. 2010
    ..Therefore, we have investigated whether screening with a rapid diagnostic test and treatment of those who are positive (IST) at routine antenatal clinic attendances is as effective and as safe as SP-IPTp in pregnant women...
  21. ncbi Prevalence of molecular markers of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine during the intermittent preventive treatment in infants coupled with the expanded program immunization in Senegal
    Babacar Faye
    Department of Parasitology, Faculty of de Medicine, Cheikh Anta Diop University of Dakar, Dakar, Senegal
    Parasitol Res 109:133-8. 2011
    Several studies have shown the efficacy of the intermittent preventive treatment (IPT) using sulfadoxine-pyrimethamine (SP) coupled with the expanded program of immunization (EPI) in infants...
  22. ncbi Effectiveness of intermittent preventive treatment with sulfadoxine-pyrimethamine during pregnancy on maternal and birth outcomes in Machinga district, Malawi
    Julie Gutman
    Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia 30322, USA
    J Infect Dis 208:907-16. 2013
    ..Despite increasing prevalence of malarial parasite resistance to sulfadoxine-pyrimethamine (SP), SP continues to be recommended for intermittent preventive treatment in pregnancy (IPTp).
  23. pmc Drug resistance maps to guide intermittent preventive treatment of malaria in African infants
    Inbarani Naidoo
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Parasitology 138:1469-79. 2011
    ..There are clear deficiencies in molecular surveillance data coverage. We discuss requirements for ongoing surveillance of SP resistance markers in support of the use of SP-IPTi...
  24. pmc The cost-effectiveness of intermittent preventive treatment for malaria in infants in Sub-Saharan Africa
    Lesong Conteh
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 5:e10313. 2010
    ..To date, there have been limited data on the cost-effectiveness of this strategy using sulfadoxine pyrimethamine (SP) and no published data on cost-effectiveness using other antimalarials.
  25. pmc Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria
    Catherine O Falade
    Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria
    Malar J 6:88. 2007
    ..This study sets out to evaluate the effectiveness of IPT-SP in the prevention of maternal and placental malaria in parturient mothers in Ibadan, Nigeria, where the risk of malaria is present all year round...
  26. pmc Effectiveness of antenatal clinics to deliver intermittent preventive treatment and insecticide treated nets for the control of malaria in pregnancy in Kenya
    Jenny Hill
    Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS ONE 8:e64913. 2013
    ..We analysed household survey data to evaluate the effectiveness of antenatal clinics (ANC) to deliver IPTp and ITNs to pregnant women in Nyando district, Kenya...
  27. pmc Antenatal receipt of sulfadoxine-pyrimethamine does not exacerbate pregnancy-associated malaria despite the expansion of drug-resistant Plasmodium falciparum: clinical outcomes from the QuEERPAM study
    Steve M Taylor
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 27599, USA
    Clin Infect Dis 55:42-50. 2012
    Antenatal intermittent preventive therapy with 2 doses of sulfadoxine-pyrimethamine (IPTp-SP) is the mainstay of efforts in sub-Saharan Africa to prevent pregnancy-associated malaria (PAM)...
  28. pmc Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan
    Najia Karim Ghanchi
    Malaria Research Lab, Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital Karolinska Institutet, Retziusväg 10, Stockholm, Sweden
    Malar J 10:18. 2011
    ..The aim of this study was, therefore, to determine the prevalence of P. falciparum resistance associated polymorphisms in field isolates from southern Pakistan...
  29. pmc In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
    Christin Sisowath
    Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 199:750-7. 2009
    ..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
  30. pmc Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women
    Harin A Karunajeewa
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Antimicrob Agents Chemother 53:4368-76. 2009
    To determine the pharmacokinetic disposition of sulfadoxine (SDOX) and pyrimethamine (PYR) when administered as intermittent presumptive treatment during pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third ..
  31. ncbi A trial of combination antimalarial therapies in children from Papua New Guinea
    Harin A Karunajeewa
    School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia
    N Engl J Med 359:2545-57. 2008
    ..Malaria control is difficult where there is intense year-round transmission of multiple plasmodium species, such as in Papua New Guinea...
  32. pmc Two strategies for the delivery of IPTc in an area of seasonal malaria transmission in the Gambia: a randomised controlled trial
    Kalifa A Bojang
    Medical Research Council Laboratories, Banjul, The Gambia
    PLoS Med 8:e1000409. 2011
    ..In rural areas, RCH trekking teams provide most of the health care to children under the age of 5 years in the Infant Welfare Clinic, and provide antenatal care for pregnant women...
  33. pmc Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children
    Lesong Conteh
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 5:e12223. 2010
    ..It is important to determine the costs associated with IPTc delivery via community based volunteers and also the potential savings to health care providers and caretakers due to malaria episodes averted as a consequence of IPTc...
  34. pmc Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya
    J Teun Bousema
    Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands
    Malar J 3:18. 2004
    ..This study identified factors that influence gametocytaemia in asymptomatic children in the absence and presence of pyrimethamine-sulphadoxine (SP) antimalarial treatment...
  35. pmc Knowledge of malaria influences the use of insecticide treated nets but not intermittent presumptive treatment by pregnant women in Tanzania
    Rhoida Y Nganda
    Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania
    Malar J 3:42. 2004
    ..This study explores the determinants of uptake for both ITNs and IPTp-SP by pregnant women and the role that individual knowledge and socio-economic status has to play for each...
  36. ncbi Pharmacokinetics of sulfadoxine and pyrimethamine in intermittent preventive treatment of malaria in pregnancy
    M M Nyunt
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin Pharmacol Ther 87:226-34. 2010
    ..In order to minimize the burden, sulfadoxine-pyrimethamine (SP) is widely used in Africa as an intermittent preventive treatment of malaria in pregnancy (..
  37. ncbi (Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate
    Petra Schneider
    Radboud University Nijmegen Medical Centre, Medical Microbiology 268, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Int J Parasitol 36:403-8. 2006
    ..Our data suggest that the potential of malaria transmission remains high even after treatment with artemisinin combination therapy, although prevalence and density of gametocytes is lower after SP+AS...
  38. ncbi Use of antenatal care services and intermittent preventive treatment for malaria among pregnant women in Blantyre District, Malawi
    Timothy H Holtz
    Malaria Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Trop Med Int Health 9:77-82. 2004
    ..We performed a cluster sample survey to study the use of sulfadoxine-pyrimethamine (SP) for IPT among recently pregnant women in February 2000 in Blantyre District, Malawi...
  39. pmc Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates
    M Imwong
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 45:3122-7. 2001
    ..0001). The dhfr PCR products of P. vivax from 32 Thai patients treated with the antifolate sulfadoxine-pyrimethamine (S-P) were investigated. All samples showed either double (53%) or triple (47%) mutations...
  40. pmc A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children
    Cheikh Sokhna
    Institut de Recherche pour le Developpement, Dakar, Senegal
    PLoS ONE 3:e1471. 2008
    ..A trial of seasonal intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) and a single dose of artesunate (AS) showed an 86% reduction in the incidence of malaria in ..
  41. pmc Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana
    Md Tauqeer Alam
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    J Infect Dis 203:220-7. 2011
    ..A comprehensive study of the drug-resistance-associated mutations and their genetic lineages will lead to a better understanding of the evolution of antimalarial drug resistance in this region...
  42. pmc Population pharmacokinetics of chloroquine and sulfadoxine and treatment response in children with malaria: suggestions for an improved dose regimen
    Celestino Obua
    Department of Pharmacology and Therapeutics, Makerere University, Kampala, Uganda
    Br J Clin Pharmacol 65:493-501. 2008
    Both chloroquine (CQ) and sulfadoxine/ pyrimethamine (SDx/PYR) remain important drugs in the control of malaria...
  43. ncbi Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparum
    Inbarani Naidoo
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Trends Parasitol 26:447-56. 2010
    ..Like CQR, dhps K540E appeared first in East Africa and spread west. We discuss whether there are common principles governing resistance dispersal in Africa and how these might guide surveillance in future...
  44. pmc Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study
    Fatuma Namusoke
    Department of Biochemistry, Makerere University, Kampala, Uganda
    Malar J 11:310. 2012
    ..The aim of this study was to assess the validity of self-reported IPTp by testing for sulphadoxine in maternal blood at delivery...
  45. ncbi Efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine on placental parasitemia in pregnant women in midwestern Nigeria
    Michael E Aziken
    Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
    Int J Gynaecol Obstet 112:30-3. 2011
    To assess the effect of intermittent preventive treatment with sulfadoxine and pyrimethamine (IPT-SP) on placental parasitemia and maternal and perinatal outcome.
  46. ncbi Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine
    Valérie Briand
    Institut de Recherche pour le Developpement, santé de la mère et de l enfant en milieu tropical, Faculte de Pharmacie, 4 avenue de l Observatoire, Paris Cedex 06, France
    J Infect Dis 200:991-1001. 2009
    In the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp).
  47. ncbi Therapeutic efficacy of chloroquine in Plasmodium vivax from areas with different epidemiological patterns in India and their Pvdhfr gene mutation pattern
    Neena Valecha
    Malaria Research Centre ICMR, 22 Sham Nath Marg, Delhi 110 054, India
    Trans R Soc Trop Med Hyg 100:831-7. 2006
    ..Although P. vivax has been reported to be inherently resistant to sulfonamide and pyrimethamine, Indian isolates exhibited only double mutations in dhfr in vitro...
  48. pmc Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda
    Patrick M Newman
    School of Medicine, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94131, USA
    Malar J 8:254. 2009
    ..TS decreases the risk of malaria in HIV-infected adults and children but has not been evaluated among pregnant women...
  49. ncbi No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon
    Martin P Grobusch
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    J Infect Dis 200:1658-61. 2009
    In the context of a trial studying intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Lambaréné, Gabon, children aged 18-30 months were followed up after having received their last dose at an age of 15 ..
  50. pmc Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central Africa
    Andrea M McCollum
    Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 52:4089-97. 2008
    b>Sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum is encoded by a number of mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes...
  51. pmc Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial
    Margaret Kweku
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 3:e4000. 2008
    ....
  52. ncbi Antifolates can have a role in the treatment of Plasmodium vivax
    Vivian N Hawkins
    Department of Genome Sciences, University of Washington, Box 355065, Seattle, WA 98195, USA
    Trends Parasitol 23:213-22. 2007
    Plasmodium vivax is a serious health concern in many regions and is sometimes inadvertently treated with sulfadoxine-pyrimethamine (SP)...
  53. ncbi Randomized trial of 2-dose versus monthly sulfadoxine-pyrimethamine intermittent preventive treatment for malaria in HIV-positive and HIV-negative pregnant women in Malawi
    Scott J Filler
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 194:286-93. 2006
    Intermittent preventive treatment during pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) decreases placental malaria parasitemia and associated maternal anemia, premature delivery, and low birth weight...
  54. pmc Determinants of use of intermittent preventive treatment of malaria in pregnancy: Jinja, Uganda
    Laura R Sangaré
    Department of Global Health, University of Washington, Seattle, Washington, USA
    PLoS ONE 5:e15066. 2010
    ..One recommended means of preventing malaria during pregnancy is intermittent preventive therapy (IPTp) with sulfadoxine/pyrimethamine (SP)...
  55. pmc Individual, facility and policy level influences on national coverage estimates for intermittent preventive treatment of malaria in pregnancy in Tanzania
    Tanya Marchant
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 7:260. 2008
    ..This investigation measured coverage of IPTp at national level in Tanzania and examined the role of individual, facility, and policy level influences on achieved coverage...
  56. pmc Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia
    A Ratcliff
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
    Trans R Soc Trop Med Hyg 101:351-9. 2007
    ..drug resistance in southern Papua, Indonesia, we assessed the therapeutic efficacy of chloroquine plus sulfadoxine-pyrimethamine (CQ+SP) for Plasmodium falciparum infections as well as CQ monotherapy for P. vivax infections...
  57. pmc Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistance
    Anwar Ahmed
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi 110029 Malaria Research Centre, 22 Sham Nath Marg, New Delhi 110054, India
    Antimicrob Agents Chemother 48:879-89. 2004
    The combination of sulfadoxine-pyrimethamine (SP) is used as a second line of therapy for the treatment of uncomplicated chloroquine-resistant Plasmodium falciparum malaria...
  58. ncbi The effect of health care worker training on the use of intermittent preventive treatment for malaria in pregnancy in rural western Kenya
    P O Ouma
    Kenya Medical Research Institute, Centre for Vector Biology and Control Research, Kisumu, Kenya
    Trop Med Int Health 12:953-61. 2007
    ..Health care workers (HCW) in Asembo were retrained on IPTp in 2003...
  59. pmc Access and barriers to measures targeted to prevent malaria in pregnancy in rural Kenya
    Priscilla W Gikandi
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya
    Trop Med Int Health 13:208-17. 2008
    ....
  60. ncbi Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
    J Infect Dis 196:1585-94. 2007
    ..However, the optimal dosing regimen in settings in which human immunodeficiency virus (HIV) is highly prevalent among pregnant women remains controversial...
  61. ncbi Ethnographic study of factors influencing compliance to intermittent preventive treatment of malaria during pregnancy among Yao women in rural Malawi
    Annika Launiala
    School of Public Health, FIN 33014 University of Tampere, Tampere, Finland
    Trans R Soc Trop Med Hyg 101:980-9. 2007
    ..This study discovered several factors affecting IPT. These were: unclear messages about IPT with sulfadoxine-pyrimethamine (SP) from nurses; timing of SP-1; periodic shortages of SP; women's limited understanding of IPT-..
  62. pmc Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infants
    Matthew Cairns
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 5:e9467. 2010
    ..Understanding the mechanism is essential for development of replacements for sulfadoxine-pyrimethamine (SP) where it is no longer effective...
  63. pmc Cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) in Mozambique and the United Republic of Tanzania
    Guy Hutton
    Swiss Tropical Institute, Basel, Switzerland
    Bull World Health Organ 87:123-9. 2009
    To estimate the cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) using sulfadoxine-pyrimethamine (SP).
  64. pmc Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali
    Mamadou Tekete
    Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Malaria Research and Training Center, Bamako, Mali
    Malar J 8:34. 2009
    ..To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria...
  65. pmc Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children
    Badara Cisse
    Department of Parasitology and Mycology, Universite Cheikh Anta Diop, Dakar, Senegal
    PLoS ONE 4:e7164. 2009
    ..cluster randomized trial to determine whether piperaquine in combination with either dihydroartemisin (DHA) or sulfadoxine-pyrimethamine (SP) is as effective, and better tolerated, than SP plus amodiaquine (AQ), when used for ..
  66. pmc Patterns of case management and chemoprevention for malaria-in-pregnancy by public and private sector health providers in Enugu state, Nigeria
    Ogochukwu C Onwujekwe
    Department of Pharmacy, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu State, Nigeria
    BMC Res Notes 5:211. 2012
    ..Information is required on how to improve its prevention and treatment from both the providers' and consumers' perspectives...
  67. pmc Quantification of the burden and consequences of pregnancy-associated malaria in the Democratic Republic of the Congo
    Steve M Taylor
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    J Infect Dis 204:1762-71. 2011
    ..Pregnancy-associated malaria (PAM) produces poor birth outcomes, but its prevalence is commonly estimated in convenience samples...
  68. ncbi High prevalence of the 437G mutation associated with sulfadoxine resistance among Plasmodium falciparum clinical isolates from Iran, three years after the introduction of sulfadoxine-pyrimethamine
    Sedigheh Zakeri
    Malaria and Vector Research Group, Biotechnology Research Center, Pasteur Institute of Iran, Pasteur Avenue, Tehran, Iran
    Int J Infect Dis 14:e123-8. 2010
    ..was to determine the frequency of dhfr and dhps resistance-associated haplotypes in Plasmodium falciparum isolates, three years after the introduction of sulfadoxine-pyrimethamine (SP) as the first-line antimalarial treatment in Iran.
  69. pmc Origin and evolution of sulfadoxine resistant Plasmodium falciparum
    Sumiti Vinayak
    Atlanta Research and Education Foundation, Atlanta, Georgia, United States of America
    PLoS Pathog 6:e1000830. 2010
    ..However, there is a dearth in understanding the origin and evolution of dhps alleles associated with sulfadoxine resistance...
  70. ncbi Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Bangui, Central African Republic
    Didier Menard
    Pasteur Institute of Bangui, Bangui, Central African Republic
    Am J Trop Med Hyg 74:205-10. 2006
    ..the baseline frequency distribution of mutant alleles of genes associated with resistance to chloroquine and sulfadoxine-pyrimethamine in Plasmodium falciparum isolates in Bangui, Central African Republic. Mutant alleles of the P...
  71. pmc Malaria prevention with IPTp during pregnancy reduces neonatal mortality
    Clara Menendez
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 5:e9438. 2010
    ..Malaria in pregnancy may affect neonatal survival, though no strong evidence exists to support this association...
  72. ncbi Selection of antifolate-resistant Plasmodium falciparum by sulfadoxine-pyrimethamine treatment and infectivity to Anopheles mosquitoes
    Fabian Mendez
    Escuela de Salud Publica, Universidad del Valle, Cali, Colombia
    Am J Trop Med Hyg 77:438-43. 2007
    ..reductase (DHFR) and dihydropteroate synthase (DHPS) in Plasmodium falciparum are selected by treatment with sulfadoxine pyrimethamine (SP)...
  73. pmc Rural Gambian women's reliance on health workers to deliver sulphadoxine-pyrimethamine as recommended intermittent preventive treatment for malaria in pregnancy
    Loretta Brabin
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester M13 OJH, UK
    Malar J 8:25. 2009
    ..The objective of this paper was to assess whether rural Gambian women were aware of the importance of the timing of the two-dose IPT dose schedule and its relevance to drug safety...
  74. ncbi Intermittent preventive treatment of malaria in pregnancy (IPTp): do frequent antenatal care visits ensure access and compliance to IPTp in Ugandan rural communities?
    Richard Ndyomugyenyi
    Malaria Control Programme, Ministry of Health, P O Box 7272, Kampala, Uganda
    Trans R Soc Trop Med Hyg 104:536-40. 2010
    ..care (ANC) visits and coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP), and barriers to IPTp-SP access were examined...
  75. ncbi HIV and placental infection modulate the appearance of drug-resistant Plasmodium falciparum in pregnant women who receive intermittent preventive treatment
    Clara Menendez
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Infect Dis 52:41-8. 2011
    ..We aimed to determine the impact of IPTp and human immunodeficiency virus (HIV) infection on molecular markers of SP resistance and the clinical relevance of resistant infections...
  76. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008
    ..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
  77. ncbi Plasmodium vivax: prevalence of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax clinical isolates from Pakistan
    Sedigheh Zakeri
    Malaria and Vector Research Group, Biotechnology Research Center, Pasteur Institute of Iran, Pasteur Avenue, PO BOX 1316943551, Tehran, Iran
    Exp Parasitol 127:167-72. 2011
    ..of the present study was to investigate the frequency of SNPs-haplotypes of dhfr and dhps genes associated to sulfadoxine-pyrimethamine (SP) resistance in Plasmodium vivax clinical isolates circulating in a malaria endemic area, ..
  78. ncbi Intermittent preventive treatment of malaria in pregnancy: at the crossroads of public health policy
    R Matthew Chico
    Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 16:774-85. 2011
    ..Clinical and operational research is urgently needed to compare birth outcomes achieved by IPTp with ABCs vs. IST using an efficacious antimalarial therapy...
  79. ncbi The efficacy of sulfadoxine-pyrimethamine alone and in combination with chloroquine for malaria treatment in rural Eastern Sudan: the interrelation between resistance, age and gametocytogenesis
    Ishraga E A-Elbasit
    Malaria Research Centre, Department of Biochemistry, University of Khartoum, Khartoum, Sudan
    Trop Med Int Health 11:604-12. 2006
    To compare the efficacy of sulfadoxine-pyremethamine (SP)+chloroquine (CQ) combination treatment against falciparum malaria with SP treatment alone.
  80. ncbi Parasitological and clinical efficacy of standard treatment regimens against Plasmodium falciparum, P. vivax and P. malariae in Papua New Guinea
    Blaise Genton
    Swiss Tropical Institute, Basel, Switzerland
    P N G Med J 48:141-50. 2005
    ..of clinical treatment failure (TF) and parasite resistance to amodiaquine (AQ), chloroquine (CQ) and quinine+sulfadoxine/pyrimethamine (Q+SP) for malaria in a rural health centre of the East Sepik Province...
  81. pmc Use of antenatal care, maternity services, intermittent presumptive treatment and insecticide treated bed nets by pregnant women in Luwero district, Uganda
    Mpungu S Kiwuwa
    Clinical Epidemiology Unit, Faculty of Medicine, Makerere University, Uganda
    Malar J 7:44. 2008
    ..This study assessed uptake of both ITNs and IPTp-SP by pregnant women as well as antenatal and maternity care use with the aim of optimizing their delivery...
  82. pmc Tracking origins and spread of sulfadoxine-resistant Plasmodium falciparum dhps alleles in Thailand
    Md Tauqeer Alam
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 55:155-64. 2011
    ..In this study we describe the origins and spread of sulfadoxine-resistance-conferring dihydropteroate synthase (dhps) alleles in Thailand...
  83. pmc Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum
    Jennifer A Flegg
    WorldWide Antimalarial Resistance Network WWARN, University of Oxford, Oxford, UK
    Malar J 12:249. 2013
    ....
  84. pmc Markers of sulfadoxine-pyrimethamine-resistant Plasmodium falciparum in placenta and circulation of pregnant women
    Frank P Mockenhaupt
    Institute of Tropical Medicine and International Health, Spandauer Damm 130, 14050 Berlin, Germany
    Antimicrob Agents Chemother 51:332-4. 2007
    Placental sequestration of Plasmodium falciparum in pregnancy may impair the usefulness of molecular markers of sulfadoxine-pyrimethamine resistance...
  85. pmc Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya
    Andrea M McCollum
    Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, GA, USA
    Malar J 11:77. 2012
    ..Importantly, the study is based on longitudinal data, which allows for a comprehensive analysis that contrasts with previous cross-sectional studies carried out in other endemic regions...
  86. pmc Bottlenecks for high coverage of intermittent preventive treatment in pregnancy: the case of adolescent pregnancies in rural Burkina Faso
    Koen Peeters Grietens
    Prince Leopold Institute for Tropical Medicine, Antwerp, Belgium
    PLoS ONE 5:e12013. 2010
    ....
  87. pmc Field evaluation of the intermittent preventive treatment of malaria during pregnancy (IPTp) in Benin: evolution of the coverage rate since its implementation
    Tania C D A d'Almeida
    Faculté des Sciences de Santé, Cotonou, Benin
    Parasit Vectors 4:108. 2011
    ..because of compliance problems and drug resistance, was replaced by intermittent preventive treatment with sulfadoxine-pyrimethamine (ITPp-SP) with two single doses taken after 16 weeks of amenorrhea, at least 4 weeks apart...
  88. pmc Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate
    Seif Shekalaghe
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 2:e1023. 2007
    ..We determined the efficacy of SP+AS plus a single dose of primaquine (PQ, 0.75 mg/kg) on clearing gametocytaemia measured by molecular methods...
  89. ncbi Mother-to-child transmission of HIV-1: association with malaria prevention, anaemia and placental malaria
    D Naniche
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    HIV Med 9:757-64. 2008
    ..Prevention of malaria in pregnancy could thus potentially affect MTCT of HIV. We studied the impact of intermittent preventive treatment during pregnancy (IPTp) on HIV-1 MTCT in southern Mozambique...
  90. pmc Placental malaria and low birth weight in pregnant women living in a rural area of Burkina Faso following the use of three preventive treatment regimens
    Alfred B Tiono
    Centre National de Recherche et de Formation sur le Paludisme, Ministere de la Sante, Ouagadougou, Burkina Faso
    Malar J 8:224. 2009
    ....
  91. pmc A trial of intermittent preventive treatment and home-based management of malaria in a rural area of The Gambia
    Sanie Sesay
    Medical Research Council Laboratories, Banjul, The Gambia
    Malar J 10:2. 2011
    ..The potential benefits of combining IPT in children (IPTc) with home management of malaria (HMM) was investigated...
  92. pmc Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria
    Sunny Oyakhirome
    Institute for Tropical Medicine, Department for Parasitology, University of Tubingen, Wilhelmstrasse 27, Tubingen, Germany
    Antimicrob Agents Chemother 51:1869-71. 2007
    Fosmidomycin-clindamycin therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine...
  93. ncbi Health workers perceptions on chloroquine and sulfadoxine/sulfalene pyrimethamine monotherapies: implications for the change to combination therapy of artemether/lumefantrine in Tanzania
    D S Tarimo
    Department of Parasitology and Medical Entomology, School of Public Health and Social Sciences, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    East Afr J Public Health 4:43-6. 2007
    ..the potential and actual barriers to the implementation of the first change of policy from chloroquine (CQ) to Sulfadoxine / Sulfalane - Pyrimewthamine (SP) in preparation for the second change of policy to Artemisinin based ..
  94. pmc Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru
    Zhiyong Zhou
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Antimicrob Agents Chemother 52:739-41. 2008
    The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16...
  95. pmc Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations
    Sankar Sridaran
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mail Stop D 67 Atlanta, GA, 30333, USA
    Malar J 9:247. 2010
    ..This meta-analysis attempts to: 1) summarize genotype frequency data that are critical for molecular surveillance of anti-folate resistance and 2) identify the specific challenges facing the development of future molecular databases...
  96. ncbi The effect of mass administration of sulfadoxine-pyrimethamine combined with artesunate on malaria incidence: a double-blind, community-randomized, placebo-controlled trial in The Gambia
    Lorenz von Seidlein
    Medical Research Council Laboratories, Fajara, The Gambia
    Trans R Soc Trop Med Hyg 97:217-25. 2003
    ..Overall 14,017 (85%) individuals living in the study area were treated with either placebo or sulfadoxine-pyrimethamine (SP) combined with a single dose of artesunate (AS)...
  97. ncbi Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso
    Christian Dokomajilar
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
    Am J Trop Med Hyg 75:162-5. 2006
    We evaluated associations between key polymorphisms in target genes and responses to treatment with sulfadoxine-pyrimethamine (SP) or amodiaquine (AQ) for uncomplicated Plasmodium falciparum malaria in Bobo-Dioulasso, Burkina Faso...
  98. pmc Residual antimalarials in malaria patients from Tanzania--implications on drug efficacy assessment and spread of parasite resistance
    Eva Maria Hodel
    Swiss Tropical Institute, Basel, Switzerland
    PLoS ONE 4:e8184. 2009
    ..We report the findings from baseline plasma sampling of malaria patients prior to inclusion into an in vivo study in Tanzania and discuss the implications of residual concentrations of antimalarials in this setting...
  99. pmc Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine-amodiaquine failure in Pikine, Senegal
    Ousmane Sarr
    Laboratory of Bacteriology and Virology, Hopital Aristide Le Dantec, BP 7325, Dakar, Senegal
    Parasitol Res 103:765-9. 2008
    ..for uncomplicated Plasmodium falciparum malaria cases has led Senegal to adopt a new combination therapy with sulfadoxine-pyrimethamine and amodiaquine (SP-AQ)...
  100. pmc Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 49:4393-5. 2005
    ..Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.
  101. ncbi Superiority of 3 over 2 doses of intermittent preventive treatment with sulfadoxine-pyrimethamine for the prevention of malaria during pregnancy in mali: a randomized controlled trial
    Oumou S Maïga Diakite
    Department of Health System Information, National Directorate of Health, University of Bamako, Bamako, Mali
    Clin Infect Dis 53:215-23. 2011
    In 2003, Mali introduced intermittent preventive therapy in pregnancy (ITPp) with sulfadoxine-pyrimethamine (SP) for the control of malaria in pregnancy, consisting of 2 doses of SP given in the 2nd and 3rd trimester...

Research Grants38

  1. Molecular epidemiology of drug resistance and population genetic structure of Pla
    Fangli Lu; Fiscal Year: 2013
    ..b>Sulfadoxine-pyrimethamine (SP) targets the dhfr and dhps genes of P...
  2. Development of a Chloroquine Replacement Drug
    MICHAEL KEVIN RISCOE; Fiscal Year: 2010
    ..drugs including: the quinolines - chloroquine, quinine, and mefloquine;the antifolates - pyrimethamine and sulfadoxine;and the anti-respiratory combination of atovaquone and proguanil...
  3. Institutional Collaboration between LSTM and CDC and Prevention on Malaria(U01)
    FEIKO OLAF TER KUILE; Fiscal Year: 2013
    ..Kenya;the central coordination of a multi-country observational study in Africa to determine the effect of sulfadoxine-pyrimethamine (SP) resistance on intermittent preventive treatment in pregnancy (IPTp) effectiveness, and two ..
  4. Inflammation, Anemia and Respiratory Distress in Mothers and Infants with Malaria
    WHITNEY ELIZABETH HARRINGTON; Fiscal Year: 2011
    ..to 20 million pregnant women in Africa receive intermittent presumptive treatment (IPTp) with the antimalarial sulfadoxine-pyrimethamine (SP) each year to prevent P...
  5. Research Activities in Support of Malaria Prevention and Control in Uganda (PMI)
    MOSES ROBERT KAMYA; Fiscal Year: 2013
    ..2) We will perform a clinical trial to measure the in vivo efficacy of sulfadoxine-pyrimethamine (SP) for the clearance of asymptomatic parasitemia in pregnant women as a means of evaluating the ..
  6. IMPACT OF TS PROPHYLAXIS ON ANTIFOLATE RESISTANT MALARIA
    James Kublin; Fiscal Year: 2000
    ..TS shares its mechanism of action with pyrimethamine-sulfadoxine (PS) and other antifolate drugs used to treat malaria...
  7. Preventing Pregnancy Malaria: Maternal-Infant Outcomes
    Michal Fried; Fiscal Year: 2009
    ..In the studies proposed here, three new IPTp regimens (chlorproguanil-dapsone (LapDap);mefloquine;sulfadoxine-pyrimethamine (SP) + azithromycin) will be compared to the currently recommended regimen (SP alone) for their ..
  8. SP resistance markers & falciparum malaria transmission
    Fabian Mendez; Fiscal Year: 2004
    ..However, resistance to the combination antifolate drug sulfadoxine-pyrimethamine (SP) has remained low in Colombia in contrast to high rates of SP failure elsewhere in the region...
  9. Synthesis and Evaluation of Novel Antimalarial Agents
    Shuren Zhu; Fiscal Year: 2005
    ..falciparum malaria parasite clones: W2 (susceptible to mefloquine but resistant to chloroquine, sulfadoxine, pyrimethamine, and quinine) and D6 (resistant to mefloquine but susceptible to chloroquine, sulfadoxine, ..
  10. Molecular epidemiology of sulfadoxine-pyrimethamine
    Thomas Egwang; Fiscal Year: 2006
    ..The government interim drug policy recommends the use of the combination therapy chloroquine and sulfadoxine-pyrimethamine (CQ/SP) as the first line treatment for uncomplicated malaria...
  11. Prevalence and fitness of drug resistant minority variant mutations in Plasmodium
    Steven Meshnick; Fiscal Year: 2009
    ..Pfcrt76 and dhfr164 fitness will be measured in paired enrollment and recrudescent samples from sulfadoxine-pyrimethamine (SP)- treated patients in Malawi and chloroquine-treated patients in Madagascar...
  12. CLINICAL AND MOLECULAR STUDIES OF DRUG-RESISTANT MALARIA
    MATTHEW DORSEY; Fiscal Year: 2005
    ..2) To evaluate molecular markers of sulfadoxine-pyrimethamine and chloroquine resistance as predictors of clinical treatment outcomes...
  13. Determinants of Drug Resistant Malaria in Nigeria
    Dyann Wirth; Fiscal Year: 2006
    ..falciparum in Nigerian isolates. We also propose to use molecular markers of chloroquine and sulfadoxine-pyrimethamine resistance as a surveillance tool for monitoring changes in the efficacy of these drugs over time ..
  14. Population Genetics of Malaria Parasites in African Highlands
    Guiyun Yan; Fiscal Year: 2007
    ..falciparum dihydrofolate reductase (DHFR) gene mutations known to confer resistance to antimalarial drug sulfadoxine-pyrimethamine...
  15. Randomized, controlled trial of daily trimethoprim-sulfamethoxazole or weekly chl
    CHRISTOPHER PLOWE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2002
    ..resistance of Plasmodium falciparum malaria to chloroquine and to the combination antifolate drug pyrimethamine-sulfadoxine (PS) is a major threat to public health in Africa...
  17. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
    ..TS shares its mechanism of action with pyrimethamine-sulfadoxine (PS) and other antifolate drugs used to treat malaria, which is responsible for an estimated 2...
  18. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2007
    ..TS shares its mechanism of action with sulfadoxine-pyrimethamine (SP) and other antifolate drugs used to treat malaria...
  19. A randomized, controlled clinical trial of chloroquine as chemoprophylaxis versus
    MIRIAM LAUFER; Fiscal Year: 2008
    ..chloroquine lost its efficacy both for preventing infection and treating disease and the antifolate combination sulfadoxine-pyrimethamine (SP) took its place...
  20. Molecular epidemiology of drug resistant malaria
    MIRIAM LAUFER; Fiscal Year: 2008
    DESCRIPTION (provided by applicant): In 1993, Malawi was the first country to switch from choloroquine to sulfadoxine-pyrimethamine (SP) as first line anti-malarial therapy due to unacceptably high failure rates with chloroquine...
  21. Drug resistant malaria clinical and laboratory studies
    Sarah Staedke; Fiscal Year: 2005
    ....
  22. Plainning malaria training in Zambia
    Thomas Eisele; Fiscal Year: 2009
    ..Tailoring a sustainable program using appropriate technology and a framework of collaboration in support of PMI activities will greatly increase the likelihood of controlling, and perhaps eventually eliminating, malaria in Zambia. ..
  23. Bladder Cancer and Urinary Schistosomiasis in Ghana
    Clive Shiff; Fiscal Year: 2004
    ..abstract_text> ..
  24. YEAST MODELS OF DRUG-RESISTANT PNEUMOCYSTIS CARINII
    Steven Meshnick; Fiscal Year: 2004
    ..Ultimately, it is hoped that the results of this study will facilitate the rational use of antipneumocystis drugs. ..
  25. MALARIA AND HIV IN PREGNANT WOMEN IN MALAWI
    Steven Meshnick; Fiscal Year: 2005
    ..The results of this study will have important implications for designing public health program s for antenatal care in African and should promote our understanding of the pathogenesis of MTCT. ..
  26. HIV & STI Transmission Dynamics along Transport Routes Linking the Americas
    KIMBERLY BROUWER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. DRUG RESISTANCE IN MALARIA
    CAROL SIBLEY; Fiscal Year: 2002
    ..When completed their experiments will provide a detailed understanding of the mutations that modify function of the Pf-DHFR and Pf-DHPS enzymes or sensitivity of the enzymes to antifolate drugs. ..
  28. MOLECULAR EVOLUTION OF P. FALCIPARUM AND P VIVAX
    Ananias Escalante; Fiscal Year: 2003
    ....
  29. Host Polymorphisms and Uncomplicated Malaria
    Sunil Parikh; Fiscal Year: 2008
    ..Parikh will be able to utilize modern molecular epidemiology techniques to investigate human genetic factors underlying susceptibility to malaria and he will be well equipped for a career in academic research. ..
  30. Molecular Epidemiology of Primary CMV Infection
    RAVIT BOGER; Fiscal Year: 2008
    ..This application will improve our understanding of acute CMV infection and will open new research directions in vaccine development. . [unreadable] [unreadable] [unreadable] [unreadable]..
  31. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..monthsfollowing the cessation of TMP-SMZ prophylaxis? 3) Will TMP-SMZ exposure increase rates of resistance to sulfadoxine-pyrimethamine, a leading antimalarial that is cross-tolerant with TMP-SMZ? These questions will be answered by ..
  32. Halogenated Xanthones as Antimalarial Agents
    Michael Riscoe; Fiscal Year: 2006
    ..Since heme is an immutable biomolecule, it is difficult to envision any simple mutation that could lead to resistance. ..
  33. Routes of Transmission of HIV in Malawian Mothers
    Steven Meshnick; Fiscal Year: 2006
    ..Thus, the results of this project will suggest a comprehensive model of the vector, the route, and the maternal factors associated with HIV vertical transmission. ..
  34. Congenital and neonatal malaria in Mali
    Abdoulaye Djimde; Fiscal Year: 2006
    ..research grant ..
  35. Antifolates as Antimalarial Drugs
    CAROL SIBLEY; Fiscal Year: 2007
    ..We think that this in depth understanding of antifolate action in the parasites will ensure that WR99210 will be developed as a useful drug for the long haul against P. falciparum and P. vivax. ..
  36. Burden of Malaria in Pregnancy in India
    Davidson Hamer; Fiscal Year: 2007
    ..The information generated by the study will also be instrumental in the development of new programs for preventing and mitigating the impact of MIP in India. [unreadable] [unreadable] [unreadable]..