Genomes and Genes
Summary: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
Publications263 found, 100 shown here
- Inhibitory effect of furosemide on non-selective voltage-independent cation channels in human erythrocytesYuliya V Kucherenko
Department of Physiology Institute I, Eberhard Karls Universitat Tubingen, Tubingen, Germany
Cell Physiol Biochem 30:863-75. 2012b>Furosemide, a loop diuretic inhibiting the renal tubular Na(+),K(+),2Cl(-) cotransporter, has been shown to decrease cytosolic Ca(2+) concentration ([Ca(2+)](i)) in platelets and erythrocytes...
- Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trialGiancarlo Marenzi
Centro Cardiologico Monzino, IRCCS, Department of Cardiovascular Sciences, University of Milan, Milan, Italy
JACC Cardiovasc Interv 5:90-7. 2012This study investigated the effect of furosemide-forced diuresis and intravenous saline infusion matched with urine output, using a novel dedicated device designed for contrast-induced nephropathy (CIN) prevention.
- Measurement of glomerular filtration rate in the conscious ratSabine Pestel
Group General Pharmacology, Drug Discovery Support, Boehringer Ingelheim Pharma GmbH and Co KG, D 88397 Biberach an der Riss, Germany
J Pharmacol Toxicol Methods 56:277-89. 2007..We developed a statistical test which allows analyzing the GFR from two different groups of animals: one used for repeated serum and the other one used for repeated urine analysis...
- Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failureMiriam T Rademaker
Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
Circ Heart Fail 2:532-40. 2009..Because any prospective new treatment is likely to be used in conjunction with standard diuretic therapy, it is necessary to investigate the combined effects of these agents...
- A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injuryGreg S Martin
Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Crit Care Med 33:1681-7. 2005..Albumin with furosemide benefits lung physiology in hypoproteinemic patients with acute lung injury/acute respiratory distress syndrome, ..
- Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransportersIgnacio Gimenez
Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain
Curr Opin Nephrol Hypertens 15:517-23. 2006Relevant advances towards understanding how furosemide-sensitive Na-K-Cl cotransporters (NKCC) are regulated by alternative splicing, phosphorylation and membrane expression have been made, which are critical to comprehending the role of ..
- Evaluation of high molecular weight poly(oxyethylene) (Polyox) polymer: studies of flow properties and release rates of furosemide and captopril from controlled-release hard gelatin capsulesM Efentakis
University of Athens, School of Pharmacy, Department of Pharmaceutical Technology, Greece
Pharm Dev Technol 5:339-46. 2000The powder characteristics and the effect of the molecular weight of polymers as diluents on the release rate of furosemide and captopril from hard gelatin capsules were evaluated...
- Effects of BG9719 (CVT-124), an A1-adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in patients with congestive heart failureS S Gottlieb
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
J Am Coll Cardiol 35:56-9. 2000To determine the effects of furosemide and the selective A1 adenosine receptor BG9719 on renal function in patients with congestive heart failure (CHF).
- Intravoxel incoherent motion and diffusion-tensor imaging in renal tissue under hydration and furosemide flow challengesEric E Sigmund
Department of Radiology, NYU Langone Medical Center, 660 First Ave, 4th Floor, New York, NY 10016, USA
Radiology 263:758-69. 2012To assess the reproducibility and the distribution of intravoxel incoherent motion (IVIM) and diffusion-tensor (DT) imaging parameters in healthy renal cortex and medulla at baseline and after hydration or furosemide challenges.
- Ethnic differences in renal responses to furosemideTae Yon Chun
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Hypertension 52:241-8. 2008..thick ascending limb, namely, the urine concentration and urinary excretion of certain cations before and after furosemide administration (40 mg IV). Subjects were healthy (ages 18 to 36 years)...
- Effect of amiloride and spironolactone on renal tubular function and central blood pressure in patients with arterial hypertension during baseline conditions and after furosemide: a double-blinded, randomized, placebo-controlled crossover trialSolveig K Matthesen
Departments of Medical Research and Medicine, Holstebro Hospital and University of Aarhus, Laegaardvej 12, Holstebro, Denmark
Clin Exp Hypertens 35:313-24. 2013..reduces ambulatory blood pressure (ABP) and central blood pressure (CBP) during baseline conditions and after furosemide and that the tubular transport via the epithelial sodium channels (ENaCs) and aquaporin-2 (AQP2) water channels ..
- Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the ratA Tahri
Laboratoire de Physiologie et Pharmacologie Cellulaire, Faculte des Sciences, Université Mohammed Premier, B P 524, 60000, Oujda, Morocco
J Ethnopharmacol 73:95-100. 2000..Urticaceae) at a low dose of 4 mg/kg/h or at a high dose of 24 mg/kg/h, or furosemide (control diuretic) at a dose of 2 mg/kg/h...
- Furosemide pharmacokinetics and pharmacodynamics following gastroretentive dosage form administration to healthy volunteersEytan A Klausner
Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, P O Box 12065, Jerusalem 91120, Israel
J Clin Pharmacol 43:711-20. 2003The objective of this study was to evaluate the pharmacokinetic and pharmacodynamic properties of furosemide following gastroretentive dosage from (GRDF) administration...
- Topical furosemide versus oral steroid in preoperative management of nasal polyposisBozidar Kroflic
Otorhinolaryngology Head and Neck Surgery Department, General Hospital, Celje, Slovenia
Eur Arch Otorhinolaryngol 263:767-71. 2006The efficacy of topical nasal furosemide treatment has been shown in the protection of nasal polyp recurrence...
- Intrinsic optical signals in the rat optic nerve: role for K(+) uptake via NKCC1 and swelling of astrocytesBrian A MacVicar
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Glia 37:114-23. 2002..The high [K(+)](o)-induced IOSs were reversibly depressed by furosemide and bumetanide, antagonists for Na-K-2Cl cotransport, but were unaltered by TTX...
- Furosemide administered before noise exposure can protect the earCahtia Adelman
Speech and Hearing Center, Hadassah University Hospital, Department of Physiology, Hebrew University Hadassah Medical School, Jerusalem, Israel
Ann Otol Rhinol Laryngol 119:342-9. 2010We assessed the effect of furosemide administration on noise-induced hearing loss...
- Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochleaKeiko Hirose
Department of Otolaryngology, Washington University, 660 South Euclid Avenue, Campus Box 8115, St Louis, MO 63110, United States
Hear Res 272:108-16. 2011..hair cell damage and monocyte migration into the mouse cochlea after kanamycin versus combined kanamycin/furosemide and explore the pathophysiology of enhanced hair cell loss in aminoglycoside ototoxicity in the presence of loop ..
- Microencapsulation of self-microemulsifying system: improving solubility and permeability of furosemideA Zvonar
Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
Int J Pharm 388:151-8. 2010..microcapsules with self-microemulsifying core to enhance the solubility and permeability of BCS class IV drug furosemide. An Inotech IE-50R encapsulator equipped with a concentric nozzle was utilized to transform liquid self-..
- The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampusTero Viitanen
Department of Biosciences, PO Box 65, FI 00014 University of Helsinki, Helsinki, Finland
J Physiol 588:1527-40. 2010..5-1 mm furosemide, a KCl cotransport inhibitor...
- Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity: a randomized trialJoseph T Santoso
University of Tennessee Cancer Institute, Memphis 38104, USA
Cancer Chemother Pharmacol 52:13-8. 2003To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity.
- Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trialPeter H J van der Voort
Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
Crit Care Med 37:533-8. 2009To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.
- Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema-based mechanismM A Collins
Department of Molecular and Cellular Biochemistry, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
FASEB J 12:221-30. 1998..However, cotreatment with the electrolyte transport inhibitor/diuretic furosemide reduces alcohol-dependent cerebrocortical damage by 75-85% while preventing brain hydration and electrolyte ..
- Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulationJ A Payne
Department of Human Physiology, University of California, School of Medicine, Davis 95616, USA
Am J Physiol 273:C1516-25. 1997..Both furosemide [inhibition constant (Ki) approximately 25 microM] and bumetanide (Ki approximately 55 microM) inhibited the NEM-..
- Furosemide and mannitol suppression of epileptic activity in the human brainMichael M Haglund
Department of Surgery Neurosurgery and Neurobiology, Durham, NC 27710, USA
J Neurophysiol 94:907-18. 2005..Patients were given a single intravenous injection containing either 20 mg furosemide (a cation-chloride cotransporter antagonist) or 50 g mannitol (an osmolyte)...
- Prediction of progression from atypical to definite Ménière's disease using electrocochleography and glycerol and furosemide testsHiroshi Kimura
Department of Otolaryngology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama City, Japan
Acta Otolaryngol 123:388-95. 2003To investigate whether electrocochleography (ECochG) and glycerol and furosemide tests could predict progression from atypical to definite Ménière's disease (MD).
- Effect of pH on the solubility and release of furosemide from polyamidoamine (PAMAM) dendrimer complexesBharathi Devarakonda
School of Pharmacy, University of Wisconsin Madison, Madison, WI 53705, USA
Int J Pharm 345:142-53. 2007The complexation of the practically insoluble drug furosemide (acidic pK(a) 3.22) with lower generation PAMAM dendrimers showed a significant release dependence on the ionization state of the drug...
- Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndromeRolf M Nusing
Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
J Am Soc Nephrol 16:2354-62. 2005..mice and in mice lacking distinct PGE2 receptors (EP1-/-, EP2-/-, EP3-/-, and EP4-/-), the effect of chronic furosemide administration (7 d) on urine output, sodium and potassium excretion, and renin secretion was determined...
- Three cases of cochleosaccular endolymphatic hydrops without vertigo revealed by furosemide-loading vestibular evoked myogenic potential testToru Seo
Department of Otolaryngology, Hyogo College of Medicine, Hyogo, Japan
Otol Neurotol 24:807-11. 2003..To describe possible cases of cochleosaccular endolymphatic hydrops without vertigo...
- High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trialFelix Cantarovich
Department of Transplantation and Intensive Care, Necker Hospital, Paris, France
Am J Kidney Dis 44:402-9. 2004The effect of furosemide on the survival and renal recovery of patients presenting with acute renal failure (ARF) is still debated.
- Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertensionCheryl L Laffer
Department of Medicine, Lenox Hill Hospital, New York University School of Medicine, New York, USA
Circulation 107:574-8. 2003..In Dahl rats, a 20-HETE deficiency plays a role in salt-sensitive (SS) hypertension. In humans, there are no data on regulation of 20-HETE by salt intake or on a role for this compound in SS hypertension...
- Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner earElizabeth C Oesterle
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, CHDD CD176, Box 357923, Seattle, WA 98195 7923, USA
J Assoc Res Otolaryngol 9:65-89. 2008..a single high-dose injection of the aminoglycoside kanamycin followed by a single injection of the loop diuretic furosemide. This drug combination causes the rapid death of outer hair cells throughout the cochlea...
- Effects of the V(2)-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in ratsT Hirano
Second Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co Ltd, Kawauchi cho, Tokushima, Japan
J Pharmacol Exp Ther 292:288-94. 2000..to characterize the diuretic effect of OPC-41061, a nonpeptide vasopressin V(2)-receptor antagonist, and furosemide by administering each alone and in combination in conscious male rats...
- PVP solid dispersions for the controlled release of furosemide from a floating multiple-unit systemV Iannuccelli
Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Italy
Drug Dev Ind Pharm 26:595-603. 2000The poor bioavailability of orally dosed furosemide (FUR) is due to the presence of a biological window in the upper gastrointestinal tract...
- Effects of oral administration of furosemide and torsemide in healthy dogsYasutomo Hori
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23 35 1 Higashi, Towada, Aomori 034 8628, Japan
Am J Vet Res 68:1058-63. 2007To investigate the diuretic effects, tolerability, and adverse effects of furosemide and torsemide after short- and long-term administration in healthy dogs.
- Treatment of hepatorenal syndrome as defined by the international ascites club by albumin and furosemide infusion according to the central venous pressure: a prospective pilot studyJean Marie Peron
Service d Hepato gastro enterologie, Fédération Digestive, Hopital Purpan, Toulouse, France
Am J Gastroenterol 100:2702-7. 2005..7 wks from the time of diagnosis. The aim of the present study was to examine the effects of albumin and furosemide administration tailored to central venous pressure (CVP) on renal function and clinical outcome.
- Furosemide, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 stateAtsushi Shiozaki
Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602 8566 Japan
J Physiol Sci 56:401-6. 2006b>Furosemide, a blocker of Na(+)/K(+)/2Cl(-) cotransporter (NKCC), is often used as a diuretic to improve edema, ascites, and pleural effusion of patients with cancers...
- Partial resolution of diabetic macular oedema after systemic treatment with furosemideA P Ciardella
Br J Ophthalmol 88:1224-5. 2004
- Mathematical modelling of the transport of hydroxypropyl-β-cyclodextrin inclusion complexes of ranitidine hydrochloride and furosemide loaded chitosan nanoparticles across a Caco-2 cell monolayerArmin Sadighi
Department of Medical Nanotechnology, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran
Int J Pharm 422:479-88. 2012Chitosan nanoparticles (CS-NPs) have been used to enhance the permeability of furosemide and ranitidine hydrochloride (ranitidine HCl) which were selected as candidates for two different biopharmaceutical drug classes having low ..
- Increased hypoxia and reduced renal tubular response to furosemide detected by BOLD magnetic resonance imaging in swine renovascular hypertensionSabas I Gomez
Department of Physiology and Biomedical Engineering, Rochester, MN 55905, USA
Am J Physiol Renal Physiol 297:F981-6. 2009..b>Furosemide-induced suppression of oxygen consumption (FSOC) involves inhibition of sodium transport in this segment, which ..
- Renal responses to furosemide are significantly attenuated in male sheep at 6 months of age following fetal uninephrectomyReetu R Singh
Dept of Anatomy and Developmental Biology, School of Biomedical Sciences, The Univ of Queensland, St Lucia, Australia
Am J Physiol Regul Integr Comp Physiol 302:R868-75. 2012..In the present study, we induced TGF blockade by furosemide administration (1...
- Differential effects of human atrial natriuretic peptide and furosemide on glomerular filtration rate and renal oxygen consumption in humansKristina Swärd
Department of Cardiothoracic Anesthesia and Intensive Care, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden
Intensive Care Med 31:79-85. 2005..We evaluated the effects of h-ANP and furosemide on renal oxygen consumption, glomerular filtration rate, and renal hemodynamics in humans.
- Effect of the calcimimetic NPS R-467 on furosemide-induced nephrocalcinosis in the young ratAnirut Pattaragarn
Section of Pediatric Nephrology, Children s Mercy Hospital, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
Kidney Int 65:1684-9. 2004b>Furosemide induces nephrocalcinosis in both humans and animals...
- Furosemide: progress in understanding its diuretic, anti-inflammatory, and bronchodilating mechanism of action, and use in the treatment of respiratory tract diseasesJoseph Prandota
Department of Pediatrics, Korczak Memorial Children s Hospital, Wroclaw, Poland
Am J Ther 9:317-28. 2002..adrenocorticosteroids and/or endogenous ouabain-like substances may play an important role in the mechanism of furosemide diuretic action. It was reported that the drug is highly bound in the adrenals, lungs, kidney, spleen, and liver...
- Effects of furosemide on renal calcium handlingChien Te Lee
Division of Nephrology, Department of Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Am J Physiol Renal Physiol 293:F1231-7. 2007b>Furosemide is a loop diuretic agent that has been used to treat hypercalcemia because it increases renal calcium excretion. The effect of furosemide on calcium transport molecules in distal tubules has yet to be investigated...
- Nano-encapsulation of furosemide microcrystals for controlled drug releaseHua Ai
Department of Biomedical Engineering, Louisiana Tech University, PO Box 10137, Ruston, LA 71272, USA
J Control Release 86:59-68. 2003b>Furosemide microcrystals were encapsulated with polyions and gelatin to control the release of the drug in aqueous solutions...
- Antihypertensive drugs clonidine, diazoxide, hydralazine and furosemide regulate the production of cytokines by placentas and peripheral blood mononuclear cells in normal pregnancyBei Xu
Vascular Immunology Research Laboratory, The Heart Research Institute, University of Sydney, Australia
J Hypertens 24:915-22. 2006Antihypertensive drugs such as clonidine, diazoxide, hydralazine and furosemide are used in the hypertensive disorders of pregnancy to control blood pressure, but it is not clear if they modulate the production of placental or circulating ..
- Effects of furosemide applied chronically to the round window: a model of metabolic presbyacusisRichard A Schmiedt
Department of Otolaryngology and Head Neck Surgery, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 22:9643-50. 2002..Here, we examine a model of presbyacusis wherein the endocochlear potential (EP) is reduced by means of furosemide applied chronically to one cochlea of a young gerbil...
- The added-up albumin enhances the diuretic effect of furosemide in patients with hypoalbuminemic chronic kidney disease: a randomized controlled studyBunyong Phakdeekitcharoen
Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
BMC Nephrol 13:92. 2012..b>Furosemide is the drug of choice for treatment...
- Chronic furosemide or hydrochlorothiazide administration increases H+-ATPase B1 subunit abundance in rat kidneyKi Young Na
Department of Internal Medicine, Seoul National University College of Medicine, Clinical Research Institute of Seoul National University Hospital, Chongno Gu, Seoul 110 744, South Korea
Am J Physiol Renal Physiol 292:F1701-9. 2007b>Furosemide administration stimulates distal acidification. This has been attributed to the increased lumen-negative voltage in the distal nephron, but the aspect of regulatory mechanisms of H(+)-ATPase has not been clear...
- Furosemide reveals heterogeneous GABA(A) receptor expression at adult rat Golgi cell to granule cell synapsesMark J Wall
Neurobiology Group, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
Neuropharmacology 43:737-49. 2002..by making whole-cell patch clamp recordings from granule cells in adult rat cerebellar slices and applying furosemide, the specific alpha6 subunit-containing GABA(A) receptor antagonist...
- Backdoor phosphorylation of basolateral plasma membranes of small intestinal epithelial cells: characterization of a furosemide-induced phosphoprotein related to the second sodium pumpLuz E Thomas
Laboratorio de Fisiologia Gastrointestinal, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 21827, 1020 A Caracas, Venezuela
Arch Biochem Biophys 419:190-7. 2003Enterocyte has two different Na+-stimulated ATPases, the ouabain-sensitive Na+/K+ ATPase and a furosemide-inhibitable Na+ ATPase...
- The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and catsMasami Uechi
Veterinary Teaching Hospital, Kitasato University Higashi, Towada, Aomori, Japan
J Vet Med Sci 65:1057-61. 2003Torasemide is a new loop diuretic that combines the effects of furosemide and spironolactone. There are no reports on the effects of torasemide in cats and dogs...
- Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failureTien M H Ng
University of Southern California School of Pharmacy and Keck School of Medicine, Los Angeles, CA 90033, USA
J Cardiovasc Pharmacol Ther 18:345-53. 2013Limited data exist comparing the efficacy and safety of bumetanide- or metolazone-based diuretic regimens to furosemide in acute heart failure (HF)...
- Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspneaT Nishino
Department of Anesthesiology, School of Medicine, Chiba University, Chiba, Japan
Am J Respir Crit Care Med 161:1963-7. 2000b>Furosemide is known to influence the activity of vagally mediated mechanoreceptors in the airways...
- Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone ratsK H Reid
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA
Brain Res 864:134-7. 2000The purpose of this study was to determine whether the loop diuretics furosemide, bumetanide and ethacrynic acid, which block the KCC1 potassium-chloride transporter in the kidney loop of Henle and the KCC2 potassium-chloride transporter ..
- Effect of furosemide on ductal closure and renal function in indomethacin-treated preterm infants during the early neonatal periodByong Sop Lee
Division of Neonatology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, South Korea
Neonatology 98:191-9. 2010b>Furosemide is known to increase renal prostaglandin synthesis. However, its influence on ductal closure and renal toxicities of indomethacin in preterm infants has not been conclusive, especially during the early neonatal period.
- The furosemide diagnostic test in suspected slow-onset heart failure: popular but not usefulJohannes C Kelder
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Eur J Heart Fail 13:513-7. 2011..The physician needs ancillary diagnostic tests. The 'loop-diuretic test' or 'furosemide test', characterized as weight loss and alleviation of symptoms after a short course of a loop-diuretic, could ..
- Urinary acidification assessed by simultaneous furosemide and fludrocortisone treatment: an alternative to ammonium chlorideS B Walsh
Department of Physiology and Centre for Nephrology, Royal Free and University College Medical School, London, UK
Kidney Int 71:1310-6. 2007..This was achieved by the simultaneous oral administration of the diuretic furosemide and the mineralocorticoid fludrocortisone to increase distal tubular sodium delivery, principal cell sodium ..
- Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemideMaki Hasegawa
Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
J Am Soc Nephrol 18:37-45. 2007..Significant ATP-dependent uptake of hydrochlorothiazide (HCT) and furosemide was observed in membrane vesicles that expressed multidrug resistance-associated protein 4 (MRP4) and breast ..
- Combined administration of kanamycin and furosemide does not result in loss of vestibular function in Guinea pigsHendrik G Bremer
Department of Otorhinolaryngology and Head and Neck Surgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Audiol Neurootol 17:25-38. 2012..The aim of our study was to investigate the effect of co-administration of kanamycin and furosemide upon the otolith organs and to compare it to the known vestibulotoxic effect of gentamicin...
- Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3Andrew K Wise
The Bionic Ear Institute, East Melbourne 3002, Australia
J Comp Neurol 487:147-65. 2005..These findings have significant implications for an improvement in the performance of the cochlear implant and for future therapies to restore hearing to the deaf...
- Novel furosemide cocrystals and selection of high solubility drug formsN Rajesh Goud
School of Chemistry, University of Hyderabad, Prof C R Rao Road, Central University PO, Gachibowli, Hyderabad 500 046, India
J Pharm Sci 101:664-80. 2012b>Furosemide was screened in cocrystallization experiments with pharmaceutically acceptable coformer molecules to discover cocrystals of improved physicochemical properties, that is high solubility and good stability...
- Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsyRegina Jauch
Johannes Müller Institut für Physiologie, Humboldt Universitat, Berlin, Germany
Brain Res 925:18-27. 2002..cells limit local K(+)-accumulation by K(+)-uptake through different mechanisms, sensitive to Ba(2+), ouabaine, furosemide, or DIDS...
- Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injuryMichael M Todd
Department of Anesthesia, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
Anesthesiology 105:1176-81. 2006b>Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear...
- Effect of furosemide on left ventricular mass in non-dialysis chronic kidney disease patients: a randomized controlled trialPasquale Zamboli
Division of Nephrology, Second University of Naples, Naples, Italy
Nephrol Dial Transplant 26:1575-83. 2011..In chronic kidney disease (CKD), loop diuretics correct volume-dependent hypertension, but their effect on left ventricular mass index (LVMI) is unknown...
- The effect of furosemide on left atrial pressure in dogs with mitral valve regurgitationS Suzuki
Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Agriculture and Technology, Tokyo, Japan
J Vet Intern Med 25:244-50. 2011The effects of furosemide on left atrial pressure (LAP) in dogs with mitral regurgitation (MR) have not been documented in a quantitative manner and between different routes of administration.
- Protective effect of inhaled furosemide on allergen-induced early and late asthmatic reactionsS Bianco
Institute of Respiratory Diseases, University of Siena, Italy
N Engl J Med 321:1069-73. 1989..In a double-blind, randomized, crossover study, we compared the effect of an aerosol of the loop diuretic furosemide with that of a placebo on the early (within 60 minutes) and late (4 to 12 hours) asthmatic responses to a ..
- Randomised, placebo controlled trial of nebulised furosemide for breathlessness in patients with cancerA Wilcock
Department of Palliative Medicine, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK
Thorax 63:872-5. 2008Breathlessness is a common and difficult symptom to treat in patients with cancer. Case reports suggest that nebulised furosemide can relieve breathlessness in such patients but few data are available.
- Biophysical insight into furosemide binding to human serum albumin: a study to unveil its impaired albumin binding in uremiaNida Zaidi
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
J Phys Chem B 117:2595-604. 2013..But transport of various drugs like a diuretic, furosemide (FUR), via albumin in uremia is seriously compromised due to accumulation of uremic toxins...
- TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failureGuido Boerrigter
Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Circ Heart Fail 5:627-34. 2012..We hypothesized that TRV120027 would elicit beneficial cardiorenal actions when added to furosemide in experimental heart failure.
- Nebulized furosemide as a novel treatment for dyspnea in terminal cancer patientsNaohito Shimoyama
Division of Pain and Palliative Care, National Cancer Center Hospital, 5 1 1 Tsukuji, Chuo Ku, Tokyo, Japan
J Pain Symptom Manage 23:73-6. 2002Three terminal cancer patients with severe dyspnea were treated with nebulized furosemide. The underlying causes of dyspnea varied. Twenty milligrams of furosemide was nebulized and inhaled four times each day...
- Comparison of the urine acidification tests of torsemide vs furosemide in healthy volunteersSang Woong Han
Nephrol Dial Transplant 20:2582-3. 2005
- Optos Optomap Panoramic 200MA imaging of a serous choroidal detachment responsive to furosemideSumit P Shah
Retina Division, Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Semin Ophthalmol 24:40-2. 2009To describe a case of a serous choroidal detachment which resulted after discontinuation of furosemide and illustrate the utility of ultrawide-angle fundus imaging in documenting this lesion in the retinal periphery.
- Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in miceYongqi Li
Center for Hearing and Deafness, University at Buffalo, 137 Cary Hall, Buffalo, NY 14214, USA
Neurotox Res 20:307-19. 2011..this problem, we developed a strategy for promoting cisplatin-induced ototoxicity by coadministration of furosemide a loop diuretic...
- Accuracy of intermediate dose of furosemide injection to improve multidetector row CT urographyCatherine Roy
Department of Radiology B, Universitary Hospital of Strasbourg Civil Hospital, 1, place de l hopital BP 426, 67091 Strasbourg Cedex, France
Eur J Radiol 66:253-61. 2008Evaluate the usefulness of intermediate dose furosemide to improve visualization of the intrarenal collecting system and ureter using MDCTU.
- Effect of nebulized furosemide in terminally ill cancer patients with dyspneaHiroyuki Kohara
Department of Internal Medicine, National Sanyo Hospital, Yamaguchi, Japan
J Pain Symptom Manage 26:962-7. 2003We evaluated the effect of ultrasonically nebulized furosemide (20 mg) on dyspnea uncontrollable by standard therapy in patients with terminal cancer...
- Effects of albumin/furosemide mixtures on responses to furosemide in hypoalbuminemic patientsN Chalasani
Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5114, USA
J Am Soc Nephrol 12:1010-6. 2001..Each patient received all of the following four treatments intravenously: (1) 40 mg of furosemide, (2) 25 g of albumin, (3) 40 mg of furosemide and 25 g of albumin premixed ex vivo, and (4) 40 mg of furosemide ..
- Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal ratsSanaa Lahlou
UFR Physiology Pharmacology, Laboratory of Animal Physiology, Department of Biology, Fez, Morocco
J Ethnopharmacol 110:458-63. 2007..Water extracts of Carum carvi and Tanacetum vulgare (100 mg/kg) or the reference drug, furosemide (10 mg/kg) were administrated orally to male Wistar rats and their urine output was quantitated at several ..
- Ototoxicity induced by gentamicin and furosemideDuane E Bates
Internal Medicine, Foothills Medical Centre, Calgary, Alberta, Canada
Ann Pharmacother 36:446-51. 2002To present a case of ototoxicity induced by furosemide and once-daily gentamicin therapy.
- Effects of furosemide on allergic asthmatic responses in miceS Wang
Institute of Physiology, Medical College of Shandong University, Shandong, China
Clin Exp Allergy 41:1456-67. 2011..Managing severe asthma is still a clinical challenge. Numerous studies report that furosemide, an inhibitor of Na(+)-K(+)-Cl(-) cotransporter (NKCC) reduces airway hyperresponsiveness (AHR) in asthmatic ..
- Continuous infusion of furosemide combined with low-dose dopamine compared to intermittent boluses in acutely decompensated heart failure is less nephrotoxic and carries a lower readmission at thirty daysEmad F Aziz
The ACAP Program, Division of Cardiology, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
Hellenic J Cardiol 52:227-35. 2011b>Furosemide is a potent loop diuretic that is widely used in the management of heart failure. Several reports have suggested that continuous intravenous administration of loop diuretics may be superior to intermittent administration...
- Re: nebulized furosemide for dyspnea in terminal cancer patientsPaddy Stone
J Pain Symptom Manage 24:274-5; author reply 275-6. 2002
- A multispecies study to assess the toxic and genotoxic effect of pharmaceuticals: furosemide and its photoproductMarina Isidori
Dipartimento di Scienze della Vita, Seconda Universita di Napoli, Via A Vivaldi, 43 I 81100 Caserta, Italy
Chemosphere 63:785-93. 2006..This study was designed to assess the ecotoxicity of furosemide, a potent diuretic agent, and its photoproduct in the aquatic environment...
- A pilot study comparing furosemide and hydrochlorothiazide in patients with hypertension and stage 4 or 5 chronic kidney diseaseBertrand Dussol
Aix Marseille Universite, Marseille, France
J Clin Hypertens (Greenwich) 14:32-7. 2012b>Furosemide is the diuretic of choice for the treatment of hypertension in chronic kidney disease but the adaptative changes in the distal nephron may decrease its efficacy...
- Presumed "sulfa allergy" in patients with intracranial hypertension treated with acetazolamide or furosemide: cross-reactivity, myth or reality?Andrew G Lee
Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Am J Ophthalmol 138:114-8. 2004To determine whether acetazolamide or furosemide produce allergic cross-reactions in patients with self-reported "sulfa allergy."
- Urinary protein binding does not affect response to furosemide in patients with nephrotic syndromeR Agarwal
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Am Soc Nephrol 11:1100-5. 2000..whether displacement from urinary protein binding with sulfisoxazole would restore response to 120 mg of furosemide. The study was stopped after treating seven patients because it was clear that sulfizoxazole had no effect...
- Furosemide-induced bullous pemphigoid: case report and review of literatureJennifer J Lee
Department of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA
J Drugs Dermatol 5:562-4. 2006..We present a case of furosemide-induced bullous pemphigoid and review the literature of drug-induced bullous pemphigoid (DIBP).
- Mechanisms of dyspnoea relief and improved exercise endurance after furosemide inhalation in COPDD Jensen
Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
Thorax 63:606-13. 2008This study examined the effects of inhaled furosemide on the ventilatory and perceptual response to high-intensity constant-load cycle exercise in chronic obstructive pulmonary disease (COPD).
- A comparison of unenhanced helical computerized tomography findings and renal obstruction determined by furosemide 99m technetium mercaptoacetyltriglycine diuretic scintirenography for patients with acute renal colicVincent G Bird
Department of Urology, University of Miami School of Medicine, Miami, Florida, USA
J Urol 167:1597-603. 2002..We assessed unenhanced helical computerized tomography (CT) secondary findings as predictors of renal obstruction as determined by diuretic scintirenography, and determined their reproducibility...
- Mechanisms of GABA(A) receptor blockade by millimolar concentrations of furosemide in isolated rat Purkinje cellsSergey N Kolbaev
Brain Research Institute, Russian Academy of Medical Sciences, Moscow, Russia
Neuropharmacology 42:913-21. 2002The action of diuretic furosemide on the GABA(A) receptor was studied in acutely isolated Purkinje cells using the whole-cell recording and fast application system...
- Narrative review: furosemide for hypercalcemia: an unproven yet common practiceSusan B Legrand
Harry R Horvitz Center for Palliative Medicine, Solid Tumor Oncology, Cleveland Clinic, Taussig Cancer Institute, 9500 Euclid Avenue R35, Cleveland, OH 44195, USA
Ann Intern Med 149:259-63. 2008..Aggressive saline hydration and varying doses of furosemide continue to be the standard of care for emergency management...
- Effects of furosemide on the tubular reabsorption of nitrates in anesthetized dogsM Rahma
Department of Pharmacology, Kagawa Medical University, Japan
Eur J Pharmacol 428:113-9. 2001..study was performed to determine the tubular sites of nitrite and nitrate (NO) reabsorption and the effects of furosemide on the renal handling of NOx in anesthetized dogs, using renal clearance and stop-flow methods...
- Modulation of ouabain-insensitive Na(+)-ATPase activity in the renal proximal tubule by Mg(2+), MgATP and furosemideC Caruso-Neves
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949 Rio de Janeiro RJ, Brazil
Int J Biochem Cell Biol 34:1586-93. 2002..In the present paper, the effects of ligands, such as Mg(2+), MgATP and furosemide on the Na(+)-ATPase and its modulation by pH were studied in the proximal renal tubule of pig...
- A randomized trial of furosemide vs hydrochlorothiazide in patients with chronic renal failure and hypertensionBertrand Dussol
Service de Néphrologie Hémodialyse Transplantation, Hopital de la Conception, 147 Bd Baille, 13385 Marseille Cedex 5, France
Nephrol Dial Transplant 20:349-53. 2005..However, the adaptive changes in the distal nephron and the short half-life of these drugs may decrease their long-term efficacy. Thiazides are not believed to be efficient in advanced renal failure, but this is debated...
- Ototoxic drugs and sensorineural hearing loss following severe neonatal respiratory failureCharlene M T Robertson
Neonatal and Infant Follow up Clinic, Glenrose Rehabilitation Hospital, Capital Health, Edmonton, Alberta T5G 0B7, Canada
Acta Paediatr 95:214-23. 2006..To determine relationships between ototoxic drugs and 4-y sensorineural hearing loss (SNHL) in near-term and term survivors of severe neonatal respiratory failure...
- Combined furosemide and human albumin treatment for diuretic-resistant edemaRowland J Elwell
Department of Pharmacy Practice, Albany College of Pharmacy, Albany, NY 12208 3492, USA
Ann Pharmacother 37:695-700. 2003To evaluate the clinical usefulness of combined furosemide and human albumin for the treatment of diuretic-resistant edema in patients with nephrotic syndrome and cirrhosis.
- Auditory response to intracochlear electric stimuli following furosemide treatmentNing Hu
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
Hear Res 185:77-89. 2003..This study extended that work by investigating the changes and subsequent recovery following furosemide injections which reversibly impair hair-cell function [Hear. Res. (1980) 79-89; Hear. Res. 14 (1984) 305-314, J...
- Furosemide-induced bullous pemphigoidK Baz
J Eur Acad Dermatol Venereol 16:81-2. 2002
- A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitroN M Barbaro
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, 513 Parnassus Avenue, Box 0520, San Francisco, San Francisco, CA 94143, USA
Neuroscience 128:655-63. 2004..In previous studies we established a powerful antiepileptic action for a commonly used diuretic (furosemide). However, it remains unclear precisely how furosemide terminates abnormal electrical discharges...
- The role of inhaled opioids and furosemide for the treatment of dyspneaRichard H Kallet
Respiratory Care Services, San Francisco General Hospital, NH GA 2, 1001 Potrero Avenue, San Francisco CA 94110, USA
Respir Care 52:900-10. 2007..Recently, aerosolized furosemide was studied for the treatment of dyspnea...
- GPR35 is a target of the loop diuretic drugs bumetanide and furosemideYuhua Yang
Department of Metabolic Disorders, Amgen San Francisco, South San Francisco, Calif 94080, USA
Pharmacology 89:13-7. 2012We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists...
- Transcriptional Regulation of Natriuetic Sensitivity in Diabetes MellitusPATIENCE O OBIH; Fiscal Year: 2012..evaluating the differential sensitivity of ion transporters in the nephron to hydrochlorothiazide, amiloride, or furosemide, as indices of activity of sodium chloride co-transporter (NCC), sodium hydrogen exchanger (NHE) and sodium-..
- Markers of Renal Damage in Renovascular HypertensionJuan C Romero; Fiscal Year: 2011..Its inhibition with furosemide suppress O2 consumption (FSOC) and decrease blood levels of deoxyhemoglobin...
- Phase III Study Comparing Albumin and Hetastarch Therapy in Acute Lung InjuryGregory S Martin; Fiscal Year: 2013..In the applicant's two prior randomized controlled trials, the treatment combination of albumin with furosemide produced the greatest improvements in arterial oxygenation and systemic hemodynamics compared to treatment with ..
- Role of Collecting Duct Chloride Transporters in Volume RegulationManoocher Soleimani; Fiscal Year: 2013..As such, we hypothesize that pendrin can confer resistance to or blunt the effect of loop or DCT diuretics (furosemide or thiazide derivatives) by increasing the absorption of salt delivered to the distal nephron...
- MR Angiography and Renography for Renovascular DiseaseVivian S Lee; Fiscal Year: 2013..We have also shown the feasibility of combining furosemide-enhanced BOLD MR with ACE-I MR renography for measuring renal ischemia in patients with RAS and have also ..
- AEROSOL FUROSEMIDE FOR DYSPNEA RELIEF: LABORATORY AND CLINICAL STUDIESRobert B Banzett; Fiscal Year: 2013..Inhaled furosemide aerosol has shown promise in relieving dyspnea with none of these side effects...
- DEVELOPMENT EFFECT ON LOOP DIURETIC OTOTOXICITYLeonard Rybak; Fiscal Year: 1999..studies of an animal model carried out by the principal investigator have demonstrated increased ototoxicity of furosemide at certain stages of development...
- HEMORRHAGIC DISEASESRICHARD HERBERT ASTER; Fiscal Year: 2013..patients suspected of DITP to identify DDAbs specific for metabolites of widely used drugs such as NSAIDs, furosemide, and clopidogrel implicated as triggers for DITP...
- Human Cardiorenal SyndromeHorng H Chen; Fiscal Year: 2013..Our Specific Aims are as follows: Aim 1: To define the effects of decreasing the furosemide dose on cardiorenal and humoral function in humans with compensated CHF and renal dysfunction and also in humans ..
- Effects of noise-induced and metabolic hearing losses on temporal coding in noiseKENNETH STUART HENRY; Fiscal Year: 2013..Aim 1 uses acoustic overexposures to study noise-induced hearing loss (NIHL), while Aim 2 uses furosemide injections to study metabolic hearing loss (MHL;furosemide injections simulate this common form of age-related ..
- ORAL DRUG DELIVERY AND BIOAVAILABILITY--AIDSGordon Amidon; Fiscal Year: 1993..the estimated extent and variation of absorption with the observed results for ddI, foscarnet, cimetidine, and furosemide or nadolol; (2) extend the transport model for drug dissolution into surfactant solutions to emulsions and apply ..
- Modulation of renin secretion by renal cortical interstitial calciumDOUG ATCHISON; Fiscal Year: 2013..changes in interstitial Ca2+ and RSR in response to the blockade of thick ascending limb NaCI reabsorption with furosemide. AIM 2: Hypothesis: In vivo stimulation of the CaR via cortical interstitial [Ca2+] decreases renin secretion...
- EXTENDED RELEASE TORSEMIDECHRISTOPHER WILCOX; Fiscal Year: 2013..However, at CKD >3-5, thiazides lose their efficacy. Patients are often switched to furosemide although this suffers from a number of limitations...
- PROSTAGLANDINS AND LOCAL CONTROL OF THE CIRCULATIONALAN NIES; Fiscal Year: 1990..for the ability of cyclooxygenase inhibitors to reduce the antihypertensive efficacy and 2) clinical studies on furosemide induced venodilation and its relation to the prostaglandin and renin-angiotensin systems...
- INTERVENTIONS TO PROMOTE VENTILATOR WEANINGKathleen Stone; Fiscal Year: 2002..are: 1) to compare the effects of preload at normovolemia and hypervolemia prior to and following diuresis with furosemide on CP hemodynamics during the transition from MV to SpV (T-piece, CPAP & PS) in normal canines (GI) and in ..
- REGULATION OF THE NA+/K+ 2C1 COTRANSPORTER PROTEINDavid Mount; Fiscal Year: 1999..This protein is the pharmacological receptor for loop diuretics (furosemide, bumetanide and ethacrynic acid), and plays a pivotal role in renal physiology...
- DIURETIC PROTECTION FROM ALCOHOL INDUCED BRAIN DAMAGEMichael Collins; Fiscal Year: 1999..Suspecting a role for edema, we examined the effect of furosemide, a potent diuretic and inhibitor of the C1- transporter that nonsynaptically blocks brain cell swelling in ..
- OXIDANT MECHANISMS IN DRUG-INDUCED HEPATIC NECROSISCharles Smith; Fiscal Year: 2006..The major models we employ are based on toxicities of diquat, acetaminophen, and furosemide in vivo and in vitro, and a limited set of model oxidants for studies in vitro...
- Modulators of CL-dependent Transport Processes (RMI)Eric Delpire; Fiscal Year: 2005..Whereas loop diuretics such as furosemide and bumetanide inhibit most cation-chloride co-transporters, these drugs are rather unspecific and not very ..
- IONIC BASIS OF ISCHEMIC CEREBRAL EDEMAWise Young; Fiscal Year: 1992..The effects of systemic furosemide, mannitol, and/or methylprednisolone on extracellular and tissue ionic shifts will be studied in the rat MCAo ..
- ONCOTIC PRESSURE AND EXTRAVASCULAR LUNG WATER IN ARDSGregory Martin; Fiscal Year: 2004..This investigational proposes a critical trial randomizing hypoproteinemic ARDS patients to albumin and furosemide or dual placebo with targeted goals of diuresis and weight loss...
- ASTROCYTE MEDIATED ETHANOL NEUROTOXICITYMichael Aschner; Fiscal Year: 2000..swelling and EAA release during EtOH withdrawal can be attenuated by anion transport blockers (SITS, DIDS, furosemide, and L-644,711)...
- Levodopa Pharmokinetic Optimization by Metal CoordinationThomas Piccariello; Fiscal Year: 2009..In rat studies, MCPs have been proven to favorably impact the PK of thyroid hormones (T3 and T4), furosemide and now, levodopa...
- FACTORS AFFECTING THE RENAL EXCRETION OF DRUGSStephen Hall; Fiscal Year: 1992..containing perfusate, will be employed to study the renal clearance of p- aminohippuric acid, chlorothiazide, furosemide and cefonicid...
- ANTINEOPLASTIC DRUG HEPATIC INTERACTIONSDean Brenner; Fiscal Year: 1990..aims include the: 1) use of bromobenzene or carbon tetrachloride to produce hepatic centrilobular lesions, furosemide to produce midzonal lesions, allyl formate to produce periportal lesions, and an hepatically implanted VX-2 ..
- ALPHA ADRENERGIC REGULATION OF THE VASCULAR NA+ PUMPStephen Navran; Fiscal Year: 1992..amiloride and its analogs to differentiate between Na+/Ca++ exchange and Na+/H+ exchange and the loop directors, furosemide and bumetamide, to identify Na+/K+/Cl- co transport...
- ROLE OF ION TRANSPORT RENAL CYST GROWTHWilliam Macias; Fiscal Year: 1992..To characterize the ion transport systems of cyst forming cells, activities will be measured in the presence of furosemide, ouabain, and amiloride...
- Function and High-Resolution of an APC superfamily amino acid transporterBliss Forbush; Fiscal Year: 2009..kidney another isoform, NKCC2, mediates salt absorption and is the site of action of the loop diuretic drugs furosemide and bumetanide...
- HYPERTENSION: PREDICTION OF BIOFEEDBACK SUCCESSCarolyn Yucha; Fiscal Year: 2002..derived from five variables: heart rate, finger temperature, forehead muscle tension, plasma renin response to furosemide, and mean arterial pressure response to furosemide...
- SALT SENSITIVITY IN BLACKS:PHYSIOLOGIC & GENETIC STUDIESCLARENCE GRIM; Fiscal Year: 1993..8.) To use molecular biological techniques to identify the chromosome subunits that hold the marker(s) for SS. These studies will lead to new ways to determine salt sensitivity in hypertensive patients...
- MOLECULAR PHYSIOLOGY AND STRUCTURE OF AQUAPORINSAlfred Van Hoek; Fiscal Year: 2002..diversity and distinct roles of aquaporins, and may also facilitate the design of water channel diuretics or "aquaretic" agents that could induce a diuresis in situations where present diuretics, such as furosemide, are ineffective.
- ISOLATION OF THE GENE ENCODING THE NA-K-C1 COTRANSPORTERJ Gargus; Fiscal Year: 1992..The goal of this project in renewal remains to determine the nature of the membrane protein(s) responsible for the furosemide- sensitive Na-K-Cl cotransport system (fs system)...
- NERVE MUSCLE SYNAPSE FORMATIONWILLIAM BETZ; Fiscal Year: 1992..For example, with the Cl pump blocked with furosemide, we will measure the rate of decline of internal Cl concentration in end plate and extrajunctional regions when ..
- PRIOR HISTORY AND SALT INTAKE RATSMary Florentine; Fiscal Year: 1993..What are the mechanisms by which pregnancy and/or lactation result in increased need-free and need-induced salt intake?..
- CALCIUM AND SALT INTAKEMICHAEL TORDOFF; Fiscal Year: 1999..e., during dietary iron or protein deficiency; reproduction; restraint; or treatment with furosemide or angiotensin-II)...
- REGULATION OF EXTRACELLULAR SPACE IN EPILEPTOGENESISPHILIP SCHWARTZKROIN; Fiscal Year: 2000..Finally, recent studies from the applicant's laboratory have shown that a commonly used diuretic, furosemide, is "anticonvulsant" in tests against a number of in vitro and in vivo models...
- MEMBRANE PERMEABILITY OF THE ASCITES TUMOR CELLSFelice Aull; Fiscal Year: 1980..Experiments to determine the mechanism of action of furosemide will continue; this diuretic drug substantially inhibits one for one chloride exchange and its effect is partly ..
- Molecular Physiology of the Na-K-CI CotransporterBliss Forbush; Fiscal Year: 2007..kidney another isoform, NKCC2, mediates salt absorption and is the site of action of the loop diuretic drugs furosemide and bumetanide...
- Neural Plasticity and Sensitization of Salt AppetiteILENE BERNSTEIN; Fiscal Year: 2007..Behavioral and physiological manipulations will involve administration of the natriuretic/diuretic agent, furosemide to produce sodium depletion and promote a sodium appetite...
- Exploration of KCC2: Role in SchizophreniaJOEL GALLAGHER; Fiscal Year: 2004..levels of protein expression of KCC2 while investigating its pharmacological manipulation with an antagonist, furosemide, in normal and c-PCP rats...
- MODULATION BY DISEASE OF EFFECT OF FUROSEMIDE IN MAND Brater; Fiscal Year: 1980..The pharmacodynamics of furosemide have been characterized in a group of normal subjects and it has been demonstrated that measures of drugs in ..
- Na-K-CI Cotransport in Pathogenesis of Airway DiseaseBeverly Koller; Fiscal Year: 2007..This observation also suggests a molecular basis for previous reports showing that furosemide, an inhibitor of NKCC1, might be useful in the treatment of asthma...
- ACTIVE TRANSPORT IN EPITHELIACHARLES STIRLING; Fiscal Year: 1980..These drugs include cardioglycosides, for example, ouabain and the so-called high ceiling diuretics such a furosemide. The technique of high resolution quantitative autoradiography is used to localize these 3H-labeled drugs...
- DEVELOPMENTAL STUDIES OF COCHLEAR MECHANICSDavid Mills; Fiscal Year: 2003..abstract_text> ..
- Proteomics of M-L antigens modulating cation transportPETER LAUF; Fiscal Year: 2004....
- Studies of cochlear mechanics: otoacoustic emissionsTianying Ren; Fiscal Year: 2005..abstract_text> ..
- Third Symposium Cell Volume & Signalling RegulationPETER LAUF; Fiscal Year: 2003..This meeting's success on U.S. soil will foster continuation of gathering of high-caliber scientists at subsequent international meetings ..
- Cue dependency with intravenous nutrients and nicotineNeil Rowland; Fiscal Year: 2007..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
- CNS AND SALT APPETITEDOUGLAS FITTS; Fiscal Year: 2004..The results will have implications for the central control of blood pressure and endocrine secretions as well as behavior during various challenges to body hydration. ..
- Physiology and genetics of food procurement in rodentsNeil Rowland; Fiscal Year: 2008..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
- C elegans:a model to study intestinal water-soluble vitamins transport in vivoHAMID SAID; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- DEVELOPMENT OF TC-99M RENAL TUBULAR AGENTSAndrew Taylor; Fiscal Year: 2008..abstract_text> ..
- Decision Support Systems for MAG3 RenographyAndrew Taylor; Fiscal Year: 2005..abstract_text> ..
- Mechanism/regulation of human intestinal thiamin uptakeHAMID SAID; Fiscal Year: 2008..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
- Inflammation & Prognosis in Decompensated Heart FailureGARY FELKER; Fiscal Year: 2008..Felker's development into an established independent clinical investigator with expertise in both complex clinical research methodology and the role of inflammation in the pathophysiology of heart failure. ..