furosemide

Summary

Summary: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.

Top Publications

  1. ncbi Inhibitory effect of furosemide on non-selective voltage-independent cation channels in human erythrocytes
    Yuliya V Kucherenko
    Department of Physiology Institute I, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Cell Physiol Biochem 30:863-75. 2012
  2. ncbi Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial
    Giancarlo Marenzi
    Centro Cardiologico Monzino, IRCCS, Department of Cardiovascular Sciences, University of Milan, Milan, Italy
    JACC Cardiovasc Interv 5:90-7. 2012
  3. ncbi Measurement of glomerular filtration rate in the conscious rat
    Sabine Pestel
    Group General Pharmacology, Drug Discovery Support, Boehringer Ingelheim Pharma GmbH and Co KG, D 88397 Biberach an der Riss, Germany
    J Pharmacol Toxicol Methods 56:277-89. 2007
  4. ncbi Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    Circ Heart Fail 2:532-40. 2009
  5. ncbi A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury
    Greg S Martin
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 33:1681-7. 2005
  6. ncbi Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters
    Ignacio Gimenez
    Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain
    Curr Opin Nephrol Hypertens 15:517-23. 2006
  7. ncbi Evaluation of high molecular weight poly(oxyethylene) (Polyox) polymer: studies of flow properties and release rates of furosemide and captopril from controlled-release hard gelatin capsules
    M Efentakis
    University of Athens, School of Pharmacy, Department of Pharmaceutical Technology, Greece
    Pharm Dev Technol 5:339-46. 2000
  8. ncbi Effects of BG9719 (CVT-124), an A1-adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in patients with congestive heart failure
    S S Gottlieb
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    J Am Coll Cardiol 35:56-9. 2000
  9. ncbi Intravoxel incoherent motion and diffusion-tensor imaging in renal tissue under hydration and furosemide flow challenges
    Eric E Sigmund
    Department of Radiology, NYU Langone Medical Center, 660 First Ave, 4th Floor, New York, NY 10016, USA
    Radiology 263:758-69. 2012
  10. ncbi Ethnic differences in renal responses to furosemide
    Tae Yon Chun
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hypertension 52:241-8. 2008

Detail Information

Publications263 found, 100 shown here

  1. ncbi Inhibitory effect of furosemide on non-selective voltage-independent cation channels in human erythrocytes
    Yuliya V Kucherenko
    Department of Physiology Institute I, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Cell Physiol Biochem 30:863-75. 2012
    b>Furosemide, a loop diuretic inhibiting the renal tubular Na(+),K(+),2Cl(-) cotransporter, has been shown to decrease cytosolic Ca(2+) concentration ([Ca(2+)](i)) in platelets and erythrocytes...
  2. ncbi Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial
    Giancarlo Marenzi
    Centro Cardiologico Monzino, IRCCS, Department of Cardiovascular Sciences, University of Milan, Milan, Italy
    JACC Cardiovasc Interv 5:90-7. 2012
    This study investigated the effect of furosemide-forced diuresis and intravenous saline infusion matched with urine output, using a novel dedicated device designed for contrast-induced nephropathy (CIN) prevention.
  3. ncbi Measurement of glomerular filtration rate in the conscious rat
    Sabine Pestel
    Group General Pharmacology, Drug Discovery Support, Boehringer Ingelheim Pharma GmbH and Co KG, D 88397 Biberach an der Riss, Germany
    J Pharmacol Toxicol Methods 56:277-89. 2007
    ..We developed a statistical test which allows analyzing the GFR from two different groups of animals: one used for repeated serum and the other one used for repeated urine analysis...
  4. ncbi Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    Circ Heart Fail 2:532-40. 2009
    ..Because any prospective new treatment is likely to be used in conjunction with standard diuretic therapy, it is necessary to investigate the combined effects of these agents...
  5. ncbi A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury
    Greg S Martin
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 33:1681-7. 2005
    ..Albumin with furosemide benefits lung physiology in hypoproteinemic patients with acute lung injury/acute respiratory distress syndrome, ..
  6. ncbi Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters
    Ignacio Gimenez
    Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain
    Curr Opin Nephrol Hypertens 15:517-23. 2006
    Relevant advances towards understanding how furosemide-sensitive Na-K-Cl cotransporters (NKCC) are regulated by alternative splicing, phosphorylation and membrane expression have been made, which are critical to comprehending the role of ..
  7. ncbi Evaluation of high molecular weight poly(oxyethylene) (Polyox) polymer: studies of flow properties and release rates of furosemide and captopril from controlled-release hard gelatin capsules
    M Efentakis
    University of Athens, School of Pharmacy, Department of Pharmaceutical Technology, Greece
    Pharm Dev Technol 5:339-46. 2000
    The powder characteristics and the effect of the molecular weight of polymers as diluents on the release rate of furosemide and captopril from hard gelatin capsules were evaluated...
  8. ncbi Effects of BG9719 (CVT-124), an A1-adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in patients with congestive heart failure
    S S Gottlieb
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    J Am Coll Cardiol 35:56-9. 2000
    To determine the effects of furosemide and the selective A1 adenosine receptor BG9719 on renal function in patients with congestive heart failure (CHF).
  9. ncbi Intravoxel incoherent motion and diffusion-tensor imaging in renal tissue under hydration and furosemide flow challenges
    Eric E Sigmund
    Department of Radiology, NYU Langone Medical Center, 660 First Ave, 4th Floor, New York, NY 10016, USA
    Radiology 263:758-69. 2012
    To assess the reproducibility and the distribution of intravoxel incoherent motion (IVIM) and diffusion-tensor (DT) imaging parameters in healthy renal cortex and medulla at baseline and after hydration or furosemide challenges.
  10. ncbi Ethnic differences in renal responses to furosemide
    Tae Yon Chun
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hypertension 52:241-8. 2008
    ..thick ascending limb, namely, the urine concentration and urinary excretion of certain cations before and after furosemide administration (40 mg IV). Subjects were healthy (ages 18 to 36 years)...
  11. ncbi Effect of amiloride and spironolactone on renal tubular function and central blood pressure in patients with arterial hypertension during baseline conditions and after furosemide: a double-blinded, randomized, placebo-controlled crossover trial
    Solveig K Matthesen
    Departments of Medical Research and Medicine, Holstebro Hospital and University of Aarhus, Laegaardvej 12, Holstebro, Denmark
    Clin Exp Hypertens 35:313-24. 2013
    ..reduces ambulatory blood pressure (ABP) and central blood pressure (CBP) during baseline conditions and after furosemide and that the tubular transport via the epithelial sodium channels (ENaCs) and aquaporin-2 (AQP2) water channels ..
  12. ncbi Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat
    A Tahri
    Laboratoire de Physiologie et Pharmacologie Cellulaire, Faculte des Sciences, Université Mohammed Premier, B P 524, 60000, Oujda, Morocco
    J Ethnopharmacol 73:95-100. 2000
    ..Urticaceae) at a low dose of 4 mg/kg/h or at a high dose of 24 mg/kg/h, or furosemide (control diuretic) at a dose of 2 mg/kg/h...
  13. ncbi Furosemide pharmacokinetics and pharmacodynamics following gastroretentive dosage form administration to healthy volunteers
    Eytan A Klausner
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, P O Box 12065, Jerusalem 91120, Israel
    J Clin Pharmacol 43:711-20. 2003
    The objective of this study was to evaluate the pharmacokinetic and pharmacodynamic properties of furosemide following gastroretentive dosage from (GRDF) administration...
  14. ncbi Topical furosemide versus oral steroid in preoperative management of nasal polyposis
    Bozidar Kroflic
    Otorhinolaryngology Head and Neck Surgery Department, General Hospital, Celje, Slovenia
    Eur Arch Otorhinolaryngol 263:767-71. 2006
    The efficacy of topical nasal furosemide treatment has been shown in the protection of nasal polyp recurrence...
  15. ncbi Intrinsic optical signals in the rat optic nerve: role for K(+) uptake via NKCC1 and swelling of astrocytes
    Brian A MacVicar
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Glia 37:114-23. 2002
    ..The high [K(+)](o)-induced IOSs were reversibly depressed by furosemide and bumetanide, antagonists for Na-K-2Cl cotransport, but were unaltered by TTX...
  16. ncbi Furosemide administered before noise exposure can protect the ear
    Cahtia Adelman
    Speech and Hearing Center, Hadassah University Hospital, Department of Physiology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Ann Otol Rhinol Laryngol 119:342-9. 2010
    We assessed the effect of furosemide administration on noise-induced hearing loss...
  17. ncbi Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea
    Keiko Hirose
    Department of Otolaryngology, Washington University, 660 South Euclid Avenue, Campus Box 8115, St Louis, MO 63110, United States
    Hear Res 272:108-16. 2011
    ..hair cell damage and monocyte migration into the mouse cochlea after kanamycin versus combined kanamycin/furosemide and explore the pathophysiology of enhanced hair cell loss in aminoglycoside ototoxicity in the presence of loop ..
  18. ncbi Microencapsulation of self-microemulsifying system: improving solubility and permeability of furosemide
    A Zvonar
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Int J Pharm 388:151-8. 2010
    ..microcapsules with self-microemulsifying core to enhance the solubility and permeability of BCS class IV drug furosemide. An Inotech IE-50R encapsulator equipped with a concentric nozzle was utilized to transform liquid self-..
  19. pmc The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus
    Tero Viitanen
    Department of Biosciences, PO Box 65, FI 00014 University of Helsinki, Helsinki, Finland
    J Physiol 588:1527-40. 2010
    ..5-1 mm furosemide, a KCl cotransport inhibitor...
  20. ncbi Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity: a randomized trial
    Joseph T Santoso
    University of Tennessee Cancer Institute, Memphis 38104, USA
    Cancer Chemother Pharmacol 52:13-8. 2003
    To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity.
  21. ncbi Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial
    Peter H J van der Voort
    Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Crit Care Med 37:533-8. 2009
    To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.
  22. ncbi Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema-based mechanism
    M A Collins
    Department of Molecular and Cellular Biochemistry, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
    FASEB J 12:221-30. 1998
    ..However, cotreatment with the electrolyte transport inhibitor/diuretic furosemide reduces alcohol-dependent cerebrocortical damage by 75-85% while preventing brain hydration and electrolyte ..
  23. ncbi Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation
    J A Payne
    Department of Human Physiology, University of California, School of Medicine, Davis 95616, USA
    Am J Physiol 273:C1516-25. 1997
    ..Both furosemide [inhibition constant (Ki) approximately 25 microM] and bumetanide (Ki approximately 55 microM) inhibited the NEM-..
  24. ncbi Furosemide and mannitol suppression of epileptic activity in the human brain
    Michael M Haglund
    Department of Surgery Neurosurgery and Neurobiology, Durham, NC 27710, USA
    J Neurophysiol 94:907-18. 2005
    ..Patients were given a single intravenous injection containing either 20 mg furosemide (a cation-chloride cotransporter antagonist) or 50 g mannitol (an osmolyte)...
  25. ncbi Prediction of progression from atypical to definite Ménière's disease using electrocochleography and glycerol and furosemide tests
    Hiroshi Kimura
    Department of Otolaryngology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama City, Japan
    Acta Otolaryngol 123:388-95. 2003
    To investigate whether electrocochleography (ECochG) and glycerol and furosemide tests could predict progression from atypical to definite Ménière's disease (MD).
  26. ncbi Effect of pH on the solubility and release of furosemide from polyamidoamine (PAMAM) dendrimer complexes
    Bharathi Devarakonda
    School of Pharmacy, University of Wisconsin Madison, Madison, WI 53705, USA
    Int J Pharm 345:142-53. 2007
    The complexation of the practically insoluble drug furosemide (acidic pK(a) 3.22) with lower generation PAMAM dendrimers showed a significant release dependence on the ionization state of the drug...
  27. ncbi Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..mice and in mice lacking distinct PGE2 receptors (EP1-/-, EP2-/-, EP3-/-, and EP4-/-), the effect of chronic furosemide administration (7 d) on urine output, sodium and potassium excretion, and renin secretion was determined...
  28. ncbi Three cases of cochleosaccular endolymphatic hydrops without vertigo revealed by furosemide-loading vestibular evoked myogenic potential test
    Toru Seo
    Department of Otolaryngology, Hyogo College of Medicine, Hyogo, Japan
    Otol Neurotol 24:807-11. 2003
    ..To describe possible cases of cochleosaccular endolymphatic hydrops without vertigo...
  29. ncbi High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trial
    Felix Cantarovich
    Department of Transplantation and Intensive Care, Necker Hospital, Paris, France
    Am J Kidney Dis 44:402-9. 2004
    The effect of furosemide on the survival and renal recovery of patients presenting with acute renal failure (ARF) is still debated.
  30. ncbi Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension
    Cheryl L Laffer
    Department of Medicine, Lenox Hill Hospital, New York University School of Medicine, New York, USA
    Circulation 107:574-8. 2003
    ..In Dahl rats, a 20-HETE deficiency plays a role in salt-sensitive (SS) hypertension. In humans, there are no data on regulation of 20-HETE by salt intake or on a role for this compound in SS hypertension...
  31. pmc Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear
    Elizabeth C Oesterle
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, CHDD CD176, Box 357923, Seattle, WA 98195 7923, USA
    J Assoc Res Otolaryngol 9:65-89. 2008
    ..a single high-dose injection of the aminoglycoside kanamycin followed by a single injection of the loop diuretic furosemide. This drug combination causes the rapid death of outer hair cells throughout the cochlea...
  32. ncbi Effects of the V(2)-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in rats
    T Hirano
    Second Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co Ltd, Kawauchi cho, Tokushima, Japan
    J Pharmacol Exp Ther 292:288-94. 2000
    ..to characterize the diuretic effect of OPC-41061, a nonpeptide vasopressin V(2)-receptor antagonist, and furosemide by administering each alone and in combination in conscious male rats...
  33. ncbi PVP solid dispersions for the controlled release of furosemide from a floating multiple-unit system
    V Iannuccelli
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Italy
    Drug Dev Ind Pharm 26:595-603. 2000
    The poor bioavailability of orally dosed furosemide (FUR) is due to the presence of a biological window in the upper gastrointestinal tract...
  34. ncbi Effects of oral administration of furosemide and torsemide in healthy dogs
    Yasutomo Hori
    Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23 35 1 Higashi, Towada, Aomori 034 8628, Japan
    Am J Vet Res 68:1058-63. 2007
    To investigate the diuretic effects, tolerability, and adverse effects of furosemide and torsemide after short- and long-term administration in healthy dogs.
  35. ncbi Treatment of hepatorenal syndrome as defined by the international ascites club by albumin and furosemide infusion according to the central venous pressure: a prospective pilot study
    Jean Marie Peron
    Service d Hepato gastro enterologie, Fédération Digestive, Hopital Purpan, Toulouse, France
    Am J Gastroenterol 100:2702-7. 2005
    ..7 wks from the time of diagnosis. The aim of the present study was to examine the effects of albumin and furosemide administration tailored to central venous pressure (CVP) on renal function and clinical outcome.
  36. ncbi Furosemide, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state
    Atsushi Shiozaki
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602 8566 Japan
    J Physiol Sci 56:401-6. 2006
    b>Furosemide, a blocker of Na(+)/K(+)/2Cl(-) cotransporter (NKCC), is often used as a diuretic to improve edema, ascites, and pleural effusion of patients with cancers...
  37. pmc Partial resolution of diabetic macular oedema after systemic treatment with furosemide
    A P Ciardella
    Br J Ophthalmol 88:1224-5. 2004
  38. ncbi Mathematical modelling of the transport of hydroxypropyl-β-cyclodextrin inclusion complexes of ranitidine hydrochloride and furosemide loaded chitosan nanoparticles across a Caco-2 cell monolayer
    Armin Sadighi
    Department of Medical Nanotechnology, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran
    Int J Pharm 422:479-88. 2012
    Chitosan nanoparticles (CS-NPs) have been used to enhance the permeability of furosemide and ranitidine hydrochloride (ranitidine HCl) which were selected as candidates for two different biopharmaceutical drug classes having low ..
  39. pmc Increased hypoxia and reduced renal tubular response to furosemide detected by BOLD magnetic resonance imaging in swine renovascular hypertension
    Sabas I Gomez
    Department of Physiology and Biomedical Engineering, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 297:F981-6. 2009
    ..b>Furosemide-induced suppression of oxygen consumption (FSOC) involves inhibition of sodium transport in this segment, which ..
  40. ncbi Renal responses to furosemide are significantly attenuated in male sheep at 6 months of age following fetal uninephrectomy
    Reetu R Singh
    Dept of Anatomy and Developmental Biology, School of Biomedical Sciences, The Univ of Queensland, St Lucia, Australia
    Am J Physiol Regul Integr Comp Physiol 302:R868-75. 2012
    ..In the present study, we induced TGF blockade by furosemide administration (1...
  41. ncbi Differential effects of human atrial natriuretic peptide and furosemide on glomerular filtration rate and renal oxygen consumption in humans
    Kristina Swärd
    Department of Cardiothoracic Anesthesia and Intensive Care, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden
    Intensive Care Med 31:79-85. 2005
    ..We evaluated the effects of h-ANP and furosemide on renal oxygen consumption, glomerular filtration rate, and renal hemodynamics in humans.
  42. ncbi Effect of the calcimimetic NPS R-467 on furosemide-induced nephrocalcinosis in the young rat
    Anirut Pattaragarn
    Section of Pediatric Nephrology, Children s Mercy Hospital, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Kidney Int 65:1684-9. 2004
    b>Furosemide induces nephrocalcinosis in both humans and animals...
  43. ncbi Furosemide: progress in understanding its diuretic, anti-inflammatory, and bronchodilating mechanism of action, and use in the treatment of respiratory tract diseases
    Joseph Prandota
    Department of Pediatrics, Korczak Memorial Children s Hospital, Wroclaw, Poland
    Am J Ther 9:317-28. 2002
    ..adrenocorticosteroids and/or endogenous ouabain-like substances may play an important role in the mechanism of furosemide diuretic action. It was reported that the drug is highly bound in the adrenals, lungs, kidney, spleen, and liver...
  44. ncbi Effects of furosemide on renal calcium handling
    Chien Te Lee
    Division of Nephrology, Department of Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Am J Physiol Renal Physiol 293:F1231-7. 2007
    b>Furosemide is a loop diuretic agent that has been used to treat hypercalcemia because it increases renal calcium excretion. The effect of furosemide on calcium transport molecules in distal tubules has yet to be investigated...
  45. ncbi Nano-encapsulation of furosemide microcrystals for controlled drug release
    Hua Ai
    Department of Biomedical Engineering, Louisiana Tech University, PO Box 10137, Ruston, LA 71272, USA
    J Control Release 86:59-68. 2003
    b>Furosemide microcrystals were encapsulated with polyions and gelatin to control the release of the drug in aqueous solutions...
  46. ncbi Antihypertensive drugs clonidine, diazoxide, hydralazine and furosemide regulate the production of cytokines by placentas and peripheral blood mononuclear cells in normal pregnancy
    Bei Xu
    Vascular Immunology Research Laboratory, The Heart Research Institute, University of Sydney, Australia
    J Hypertens 24:915-22. 2006
    Antihypertensive drugs such as clonidine, diazoxide, hydralazine and furosemide are used in the hypertensive disorders of pregnancy to control blood pressure, but it is not clear if they modulate the production of placental or circulating ..
  47. ncbi Effects of furosemide applied chronically to the round window: a model of metabolic presbyacusis
    Richard A Schmiedt
    Department of Otolaryngology and Head Neck Surgery, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 22:9643-50. 2002
    ..Here, we examine a model of presbyacusis wherein the endocochlear potential (EP) is reduced by means of furosemide applied chronically to one cochlea of a young gerbil...
  48. pmc The added-up albumin enhances the diuretic effect of furosemide in patients with hypoalbuminemic chronic kidney disease: a randomized controlled study
    Bunyong Phakdeekitcharoen
    Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    BMC Nephrol 13:92. 2012
    ..b>Furosemide is the drug of choice for treatment...
  49. ncbi Chronic furosemide or hydrochlorothiazide administration increases H+-ATPase B1 subunit abundance in rat kidney
    Ki Young Na
    Department of Internal Medicine, Seoul National University College of Medicine, Clinical Research Institute of Seoul National University Hospital, Chongno Gu, Seoul 110 744, South Korea
    Am J Physiol Renal Physiol 292:F1701-9. 2007
    b>Furosemide administration stimulates distal acidification. This has been attributed to the increased lumen-negative voltage in the distal nephron, but the aspect of regulatory mechanisms of H(+)-ATPase has not been clear...
  50. ncbi Furosemide reveals heterogeneous GABA(A) receptor expression at adult rat Golgi cell to granule cell synapses
    Mark J Wall
    Neurobiology Group, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Neuropharmacology 43:737-49. 2002
    ..by making whole-cell patch clamp recordings from granule cells in adult rat cerebellar slices and applying furosemide, the specific alpha6 subunit-containing GABA(A) receptor antagonist...
  51. ncbi Backdoor phosphorylation of basolateral plasma membranes of small intestinal epithelial cells: characterization of a furosemide-induced phosphoprotein related to the second sodium pump
    Luz E Thomas
    Laboratorio de Fisiologia Gastrointestinal, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 21827, 1020 A Caracas, Venezuela
    Arch Biochem Biophys 419:190-7. 2003
    Enterocyte has two different Na+-stimulated ATPases, the ouabain-sensitive Na+/K+ ATPase and a furosemide-inhibitable Na+ ATPase...
  52. ncbi The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats
    Masami Uechi
    Veterinary Teaching Hospital, Kitasato University Higashi, Towada, Aomori, Japan
    J Vet Med Sci 65:1057-61. 2003
    Torasemide is a new loop diuretic that combines the effects of furosemide and spironolactone. There are no reports on the effects of torasemide in cats and dogs...
  53. ncbi Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure
    Tien M H Ng
    University of Southern California School of Pharmacy and Keck School of Medicine, Los Angeles, CA 90033, USA
    J Cardiovasc Pharmacol Ther 18:345-53. 2013
    Limited data exist comparing the efficacy and safety of bumetanide- or metolazone-based diuretic regimens to furosemide in acute heart failure (HF)...
  54. ncbi Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea
    T Nishino
    Department of Anesthesiology, School of Medicine, Chiba University, Chiba, Japan
    Am J Respir Crit Care Med 161:1963-7. 2000
    b>Furosemide is known to influence the activity of vagally mediated mechanoreceptors in the airways...
  55. ncbi Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats
    K H Reid
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA
    Brain Res 864:134-7. 2000
    The purpose of this study was to determine whether the loop diuretics furosemide, bumetanide and ethacrynic acid, which block the KCC1 potassium-chloride transporter in the kidney loop of Henle and the KCC2 potassium-chloride transporter ..
  56. ncbi Effect of furosemide on ductal closure and renal function in indomethacin-treated preterm infants during the early neonatal period
    Byong Sop Lee
    Division of Neonatology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, South Korea
    Neonatology 98:191-9. 2010
    b>Furosemide is known to increase renal prostaglandin synthesis. However, its influence on ductal closure and renal toxicities of indomethacin in preterm infants has not been conclusive, especially during the early neonatal period.
  57. ncbi The furosemide diagnostic test in suspected slow-onset heart failure: popular but not useful
    Johannes C Kelder
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Eur J Heart Fail 13:513-7. 2011
    ..The physician needs ancillary diagnostic tests. The 'loop-diuretic test' or 'furosemide test', characterized as weight loss and alleviation of symptoms after a short course of a loop-diuretic, could ..
  58. ncbi Urinary acidification assessed by simultaneous furosemide and fludrocortisone treatment: an alternative to ammonium chloride
    S B Walsh
    Department of Physiology and Centre for Nephrology, Royal Free and University College Medical School, London, UK
    Kidney Int 71:1310-6. 2007
    ..This was achieved by the simultaneous oral administration of the diuretic furosemide and the mineralocorticoid fludrocortisone to increase distal tubular sodium delivery, principal cell sodium ..
  59. ncbi Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide
    Maki Hasegawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    J Am Soc Nephrol 18:37-45. 2007
    ..Significant ATP-dependent uptake of hydrochlorothiazide (HCT) and furosemide was observed in membrane vesicles that expressed multidrug resistance-associated protein 4 (MRP4) and breast ..
  60. ncbi Combined administration of kanamycin and furosemide does not result in loss of vestibular function in Guinea pigs
    Hendrik G Bremer
    Department of Otorhinolaryngology and Head and Neck Surgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Audiol Neurootol 17:25-38. 2012
    ..The aim of our study was to investigate the effect of co-administration of kanamycin and furosemide upon the otolith organs and to compare it to the known vestibulotoxic effect of gentamicin...
  61. ncbi Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3
    Andrew K Wise
    The Bionic Ear Institute, East Melbourne 3002, Australia
    J Comp Neurol 487:147-65. 2005
    ..These findings have significant implications for an improvement in the performance of the cochlear implant and for future therapies to restore hearing to the deaf...
  62. ncbi Novel furosemide cocrystals and selection of high solubility drug forms
    N Rajesh Goud
    School of Chemistry, University of Hyderabad, Prof C R Rao Road, Central University PO, Gachibowli, Hyderabad 500 046, India
    J Pharm Sci 101:664-80. 2012
    b>Furosemide was screened in cocrystallization experiments with pharmaceutically acceptable coformer molecules to discover cocrystals of improved physicochemical properties, that is high solubility and good stability...
  63. ncbi Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy
    Regina Jauch
    Johannes Müller Institut für Physiologie, Humboldt Universitat, Berlin, Germany
    Brain Res 925:18-27. 2002
    ..cells limit local K(+)-accumulation by K(+)-uptake through different mechanisms, sensitive to Ba(2+), ouabaine, furosemide, or DIDS...
  64. ncbi Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury
    Michael M Todd
    Department of Anesthesia, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Anesthesiology 105:1176-81. 2006
    b>Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear...
  65. ncbi Effect of furosemide on left ventricular mass in non-dialysis chronic kidney disease patients: a randomized controlled trial
    Pasquale Zamboli
    Division of Nephrology, Second University of Naples, Naples, Italy
    Nephrol Dial Transplant 26:1575-83. 2011
    ..In chronic kidney disease (CKD), loop diuretics correct volume-dependent hypertension, but their effect on left ventricular mass index (LVMI) is unknown...
  66. ncbi The effect of furosemide on left atrial pressure in dogs with mitral valve regurgitation
    S Suzuki
    Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Agriculture and Technology, Tokyo, Japan
    J Vet Intern Med 25:244-50. 2011
    The effects of furosemide on left atrial pressure (LAP) in dogs with mitral regurgitation (MR) have not been documented in a quantitative manner and between different routes of administration.
  67. ncbi Protective effect of inhaled furosemide on allergen-induced early and late asthmatic reactions
    S Bianco
    Institute of Respiratory Diseases, University of Siena, Italy
    N Engl J Med 321:1069-73. 1989
    ..In a double-blind, randomized, crossover study, we compared the effect of an aerosol of the loop diuretic furosemide with that of a placebo on the early (within 60 minutes) and late (4 to 12 hours) asthmatic responses to a ..
  68. ncbi Randomised, placebo controlled trial of nebulised furosemide for breathlessness in patients with cancer
    A Wilcock
    Department of Palliative Medicine, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK
    Thorax 63:872-5. 2008
    Breathlessness is a common and difficult symptom to treat in patients with cancer. Case reports suggest that nebulised furosemide can relieve breathlessness in such patients but few data are available.
  69. ncbi Biophysical insight into furosemide binding to human serum albumin: a study to unveil its impaired albumin binding in uremia
    Nida Zaidi
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
    J Phys Chem B 117:2595-604. 2013
    ..But transport of various drugs like a diuretic, furosemide (FUR), via albumin in uremia is seriously compromised due to accumulation of uremic toxins...
  70. ncbi TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure
    Guido Boerrigter
    Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Circ Heart Fail 5:627-34. 2012
    ..We hypothesized that TRV120027 would elicit beneficial cardiorenal actions when added to furosemide in experimental heart failure.
  71. ncbi Nebulized furosemide as a novel treatment for dyspnea in terminal cancer patients
    Naohito Shimoyama
    Division of Pain and Palliative Care, National Cancer Center Hospital, 5 1 1 Tsukuji, Chuo Ku, Tokyo, Japan
    J Pain Symptom Manage 23:73-6. 2002
    Three terminal cancer patients with severe dyspnea were treated with nebulized furosemide. The underlying causes of dyspnea varied. Twenty milligrams of furosemide was nebulized and inhaled four times each day...
  72. ncbi Comparison of the urine acidification tests of torsemide vs furosemide in healthy volunteers
    Sang Woong Han
    Nephrol Dial Transplant 20:2582-3. 2005
  73. ncbi Optos Optomap Panoramic 200MA imaging of a serous choroidal detachment responsive to furosemide
    Sumit P Shah
    Retina Division, Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Semin Ophthalmol 24:40-2. 2009
    To describe a case of a serous choroidal detachment which resulted after discontinuation of furosemide and illustrate the utility of ultrawide-angle fundus imaging in documenting this lesion in the retinal periphery.
  74. pmc Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice
    Yongqi Li
    Center for Hearing and Deafness, University at Buffalo, 137 Cary Hall, Buffalo, NY 14214, USA
    Neurotox Res 20:307-19. 2011
    ..this problem, we developed a strategy for promoting cisplatin-induced ototoxicity by coadministration of furosemide a loop diuretic...
  75. ncbi Accuracy of intermediate dose of furosemide injection to improve multidetector row CT urography
    Catherine Roy
    Department of Radiology B, Universitary Hospital of Strasbourg Civil Hospital, 1, place de l hopital BP 426, 67091 Strasbourg Cedex, France
    Eur J Radiol 66:253-61. 2008
    Evaluate the usefulness of intermediate dose furosemide to improve visualization of the intrarenal collecting system and ureter using MDCTU.
  76. ncbi Effect of nebulized furosemide in terminally ill cancer patients with dyspnea
    Hiroyuki Kohara
    Department of Internal Medicine, National Sanyo Hospital, Yamaguchi, Japan
    J Pain Symptom Manage 26:962-7. 2003
    We evaluated the effect of ultrasonically nebulized furosemide (20 mg) on dyspnea uncontrollable by standard therapy in patients with terminal cancer...
  77. ncbi Effects of albumin/furosemide mixtures on responses to furosemide in hypoalbuminemic patients
    N Chalasani
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5114, USA
    J Am Soc Nephrol 12:1010-6. 2001
    ..Each patient received all of the following four treatments intravenously: (1) 40 mg of furosemide, (2) 25 g of albumin, (3) 40 mg of furosemide and 25 g of albumin premixed ex vivo, and (4) 40 mg of furosemide ..
  78. ncbi Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats
    Sanaa Lahlou
    UFR Physiology Pharmacology, Laboratory of Animal Physiology, Department of Biology, Fez, Morocco
    J Ethnopharmacol 110:458-63. 2007
    ..Water extracts of Carum carvi and Tanacetum vulgare (100 mg/kg) or the reference drug, furosemide (10 mg/kg) were administrated orally to male Wistar rats and their urine output was quantitated at several ..
  79. ncbi Ototoxicity induced by gentamicin and furosemide
    Duane E Bates
    Internal Medicine, Foothills Medical Centre, Calgary, Alberta, Canada
    Ann Pharmacother 36:446-51. 2002
    To present a case of ototoxicity induced by furosemide and once-daily gentamicin therapy.
  80. ncbi Effects of furosemide on allergic asthmatic responses in mice
    S Wang
    Institute of Physiology, Medical College of Shandong University, Shandong, China
    Clin Exp Allergy 41:1456-67. 2011
    ..Managing severe asthma is still a clinical challenge. Numerous studies report that furosemide, an inhibitor of Na(+)-K(+)-Cl(-) cotransporter (NKCC) reduces airway hyperresponsiveness (AHR) in asthmatic ..
  81. ncbi Continuous infusion of furosemide combined with low-dose dopamine compared to intermittent boluses in acutely decompensated heart failure is less nephrotoxic and carries a lower readmission at thirty days
    Emad F Aziz
    The ACAP Program, Division of Cardiology, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Hellenic J Cardiol 52:227-35. 2011
    b>Furosemide is a potent loop diuretic that is widely used in the management of heart failure. Several reports have suggested that continuous intravenous administration of loop diuretics may be superior to intermittent administration...
  82. ncbi Re: nebulized furosemide for dyspnea in terminal cancer patients
    Paddy Stone
    J Pain Symptom Manage 24:274-5; author reply 275-6. 2002
  83. ncbi A multispecies study to assess the toxic and genotoxic effect of pharmaceuticals: furosemide and its photoproduct
    Marina Isidori
    Dipartimento di Scienze della Vita, Seconda Universita di Napoli, Via A Vivaldi, 43 I 81100 Caserta, Italy
    Chemosphere 63:785-93. 2006
    ..This study was designed to assess the ecotoxicity of furosemide, a potent diuretic agent, and its photoproduct in the aquatic environment...
  84. ncbi A pilot study comparing furosemide and hydrochlorothiazide in patients with hypertension and stage 4 or 5 chronic kidney disease
    Bertrand Dussol
    Aix Marseille Universite, Marseille, France
    J Clin Hypertens (Greenwich) 14:32-7. 2012
    b>Furosemide is the diuretic of choice for the treatment of hypertension in chronic kidney disease but the adaptative changes in the distal nephron may decrease its efficacy...
  85. ncbi Presumed "sulfa allergy" in patients with intracranial hypertension treated with acetazolamide or furosemide: cross-reactivity, myth or reality?
    Andrew G Lee
    Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Am J Ophthalmol 138:114-8. 2004
    To determine whether acetazolamide or furosemide produce allergic cross-reactions in patients with self-reported "sulfa allergy."
  86. ncbi Urinary protein binding does not affect response to furosemide in patients with nephrotic syndrome
    R Agarwal
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Am Soc Nephrol 11:1100-5. 2000
    ..whether displacement from urinary protein binding with sulfisoxazole would restore response to 120 mg of furosemide. The study was stopped after treating seven patients because it was clear that sulfizoxazole had no effect...
  87. ncbi Furosemide-induced bullous pemphigoid: case report and review of literature
    Jennifer J Lee
    Department of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA
    J Drugs Dermatol 5:562-4. 2006
    ..We present a case of furosemide-induced bullous pemphigoid and review the literature of drug-induced bullous pemphigoid (DIBP).
  88. ncbi Mechanisms of dyspnoea relief and improved exercise endurance after furosemide inhalation in COPD
    D Jensen
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Thorax 63:606-13. 2008
    This study examined the effects of inhaled furosemide on the ventilatory and perceptual response to high-intensity constant-load cycle exercise in chronic obstructive pulmonary disease (COPD).
  89. ncbi A comparison of unenhanced helical computerized tomography findings and renal obstruction determined by furosemide 99m technetium mercaptoacetyltriglycine diuretic scintirenography for patients with acute renal colic
    Vincent G Bird
    Department of Urology, University of Miami School of Medicine, Miami, Florida, USA
    J Urol 167:1597-603. 2002
    ..We assessed unenhanced helical computerized tomography (CT) secondary findings as predictors of renal obstruction as determined by diuretic scintirenography, and determined their reproducibility...
  90. ncbi Mechanisms of GABA(A) receptor blockade by millimolar concentrations of furosemide in isolated rat Purkinje cells
    Sergey N Kolbaev
    Brain Research Institute, Russian Academy of Medical Sciences, Moscow, Russia
    Neuropharmacology 42:913-21. 2002
    The action of diuretic furosemide on the GABA(A) receptor was studied in acutely isolated Purkinje cells using the whole-cell recording and fast application system...
  91. ncbi Narrative review: furosemide for hypercalcemia: an unproven yet common practice
    Susan B Legrand
    Harry R Horvitz Center for Palliative Medicine, Solid Tumor Oncology, Cleveland Clinic, Taussig Cancer Institute, 9500 Euclid Avenue R35, Cleveland, OH 44195, USA
    Ann Intern Med 149:259-63. 2008
    ..Aggressive saline hydration and varying doses of furosemide continue to be the standard of care for emergency management...
  92. ncbi Effects of furosemide on the tubular reabsorption of nitrates in anesthetized dogs
    M Rahma
    Department of Pharmacology, Kagawa Medical University, Japan
    Eur J Pharmacol 428:113-9. 2001
    ..study was performed to determine the tubular sites of nitrite and nitrate (NO) reabsorption and the effects of furosemide on the renal handling of NOx in anesthetized dogs, using renal clearance and stop-flow methods...
  93. ncbi Modulation of ouabain-insensitive Na(+)-ATPase activity in the renal proximal tubule by Mg(2+), MgATP and furosemide
    C Caruso-Neves
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949 Rio de Janeiro RJ, Brazil
    Int J Biochem Cell Biol 34:1586-93. 2002
    ..In the present paper, the effects of ligands, such as Mg(2+), MgATP and furosemide on the Na(+)-ATPase and its modulation by pH were studied in the proximal renal tubule of pig...
  94. ncbi A randomized trial of furosemide vs hydrochlorothiazide in patients with chronic renal failure and hypertension
    Bertrand Dussol
    Service de Néphrologie Hémodialyse Transplantation, Hopital de la Conception, 147 Bd Baille, 13385 Marseille Cedex 5, France
    Nephrol Dial Transplant 20:349-53. 2005
    ..However, the adaptive changes in the distal nephron and the short half-life of these drugs may decrease their long-term efficacy. Thiazides are not believed to be efficient in advanced renal failure, but this is debated...
  95. ncbi Ototoxic drugs and sensorineural hearing loss following severe neonatal respiratory failure
    Charlene M T Robertson
    Neonatal and Infant Follow up Clinic, Glenrose Rehabilitation Hospital, Capital Health, Edmonton, Alberta T5G 0B7, Canada
    Acta Paediatr 95:214-23. 2006
    ..To determine relationships between ototoxic drugs and 4-y sensorineural hearing loss (SNHL) in near-term and term survivors of severe neonatal respiratory failure...
  96. ncbi Combined furosemide and human albumin treatment for diuretic-resistant edema
    Rowland J Elwell
    Department of Pharmacy Practice, Albany College of Pharmacy, Albany, NY 12208 3492, USA
    Ann Pharmacother 37:695-700. 2003
    To evaluate the clinical usefulness of combined furosemide and human albumin for the treatment of diuretic-resistant edema in patients with nephrotic syndrome and cirrhosis.
  97. ncbi Auditory response to intracochlear electric stimuli following furosemide treatment
    Ning Hu
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Hear Res 185:77-89. 2003
    ..This study extended that work by investigating the changes and subsequent recovery following furosemide injections which reversibly impair hair-cell function [Hear. Res. (1980) 79-89; Hear. Res. 14 (1984) 305-314, J...
  98. ncbi Furosemide-induced bullous pemphigoid
    K Baz
    J Eur Acad Dermatol Venereol 16:81-2. 2002
  99. ncbi A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro
    N M Barbaro
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, 513 Parnassus Avenue, Box 0520, San Francisco, San Francisco, CA 94143, USA
    Neuroscience 128:655-63. 2004
    ..In previous studies we established a powerful antiepileptic action for a commonly used diuretic (furosemide). However, it remains unclear precisely how furosemide terminates abnormal electrical discharges...
  100. ncbi The role of inhaled opioids and furosemide for the treatment of dyspnea
    Richard H Kallet
    Respiratory Care Services, San Francisco General Hospital, NH GA 2, 1001 Potrero Avenue, San Francisco CA 94110, USA
    Respir Care 52:900-10. 2007
    ..Recently, aerosolized furosemide was studied for the treatment of dyspnea...
  101. ncbi GPR35 is a target of the loop diuretic drugs bumetanide and furosemide
    Yuhua Yang
    Department of Metabolic Disorders, Amgen San Francisco, South San Francisco, Calif 94080, USA
    Pharmacology 89:13-7. 2012
    We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists...

Research Grants62

  1. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..evaluating the differential sensitivity of ion transporters in the nephron to hydrochlorothiazide, amiloride, or furosemide, as indices of activity of sodium chloride co-transporter (NCC), sodium hydrogen exchanger (NHE) and sodium-..
  2. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..Its inhibition with furosemide suppress O2 consumption (FSOC) and decrease blood levels of deoxyhemoglobin...
  3. Phase III Study Comparing Albumin and Hetastarch Therapy in Acute Lung Injury
    Gregory S Martin; Fiscal Year: 2013
    ..In the applicant's two prior randomized controlled trials, the treatment combination of albumin with furosemide produced the greatest improvements in arterial oxygenation and systemic hemodynamics compared to treatment with ..
  4. Role of Collecting Duct Chloride Transporters in Volume Regulation
    Manoocher Soleimani; Fiscal Year: 2013
    ..As such, we hypothesize that pendrin can confer resistance to or blunt the effect of loop or DCT diuretics (furosemide or thiazide derivatives) by increasing the absorption of salt delivered to the distal nephron...
  5. MR Angiography and Renography for Renovascular Disease
    Vivian S Lee; Fiscal Year: 2013
    ..We have also shown the feasibility of combining furosemide-enhanced BOLD MR with ACE-I MR renography for measuring renal ischemia in patients with RAS and have also ..
  6. AEROSOL FUROSEMIDE FOR DYSPNEA RELIEF: LABORATORY AND CLINICAL STUDIES
    Robert B Banzett; Fiscal Year: 2013
    ..Inhaled furosemide aerosol has shown promise in relieving dyspnea with none of these side effects...
  7. DEVELOPMENT EFFECT ON LOOP DIURETIC OTOTOXICITY
    Leonard Rybak; Fiscal Year: 1999
    ..studies of an animal model carried out by the principal investigator have demonstrated increased ototoxicity of furosemide at certain stages of development...
  8. HEMORRHAGIC DISEASES
    RICHARD HERBERT ASTER; Fiscal Year: 2013
    ..patients suspected of DITP to identify DDAbs specific for metabolites of widely used drugs such as NSAIDs, furosemide, and clopidogrel implicated as triggers for DITP...
  9. Human Cardiorenal Syndrome
    Horng H Chen; Fiscal Year: 2013
    ..Our Specific Aims are as follows: Aim 1: To define the effects of decreasing the furosemide dose on cardiorenal and humoral function in humans with compensated CHF and renal dysfunction and also in humans ..
  10. Effects of noise-induced and metabolic hearing losses on temporal coding in noise
    KENNETH STUART HENRY; Fiscal Year: 2013
    ..Aim 1 uses acoustic overexposures to study noise-induced hearing loss (NIHL), while Aim 2 uses furosemide injections to study metabolic hearing loss (MHL;furosemide injections simulate this common form of age-related ..
  11. ORAL DRUG DELIVERY AND BIOAVAILABILITY--AIDS
    Gordon Amidon; Fiscal Year: 1993
    ..the estimated extent and variation of absorption with the observed results for ddI, foscarnet, cimetidine, and furosemide or nadolol; (2) extend the transport model for drug dissolution into surfactant solutions to emulsions and apply ..
  12. Modulation of renin secretion by renal cortical interstitial calcium
    DOUG ATCHISON; Fiscal Year: 2013
    ..changes in interstitial Ca2+ and RSR in response to the blockade of thick ascending limb NaCI reabsorption with furosemide. AIM 2: Hypothesis: In vivo stimulation of the CaR via cortical interstitial [Ca2+] decreases renin secretion...
  13. EXTENDED RELEASE TORSEMIDE
    CHRISTOPHER WILCOX; Fiscal Year: 2013
    ..However, at CKD >3-5, thiazides lose their efficacy. Patients are often switched to furosemide although this suffers from a number of limitations...
  14. PROSTAGLANDINS AND LOCAL CONTROL OF THE CIRCULATION
    ALAN NIES; Fiscal Year: 1990
    ..for the ability of cyclooxygenase inhibitors to reduce the antihypertensive efficacy and 2) clinical studies on furosemide induced venodilation and its relation to the prostaglandin and renin-angiotensin systems...
  15. INTERVENTIONS TO PROMOTE VENTILATOR WEANING
    Kathleen Stone; Fiscal Year: 2002
    ..are: 1) to compare the effects of preload at normovolemia and hypervolemia prior to and following diuresis with furosemide on CP hemodynamics during the transition from MV to SpV (T-piece, CPAP & PS) in normal canines (GI) and in ..
  16. REGULATION OF THE NA+/K+ 2C1 COTRANSPORTER PROTEIN
    David Mount; Fiscal Year: 1999
    ..This protein is the pharmacological receptor for loop diuretics (furosemide, bumetanide and ethacrynic acid), and plays a pivotal role in renal physiology...
  17. DIURETIC PROTECTION FROM ALCOHOL INDUCED BRAIN DAMAGE
    Michael Collins; Fiscal Year: 1999
    ..Suspecting a role for edema, we examined the effect of furosemide, a potent diuretic and inhibitor of the C1- transporter that nonsynaptically blocks brain cell swelling in ..
  18. OXIDANT MECHANISMS IN DRUG-INDUCED HEPATIC NECROSIS
    Charles Smith; Fiscal Year: 2006
    ..The major models we employ are based on toxicities of diquat, acetaminophen, and furosemide in vivo and in vitro, and a limited set of model oxidants for studies in vitro...
  19. Modulators of CL-dependent Transport Processes (RMI)
    Eric Delpire; Fiscal Year: 2005
    ..Whereas loop diuretics such as furosemide and bumetanide inhibit most cation-chloride co-transporters, these drugs are rather unspecific and not very ..
  20. IONIC BASIS OF ISCHEMIC CEREBRAL EDEMA
    Wise Young; Fiscal Year: 1992
    ..The effects of systemic furosemide, mannitol, and/or methylprednisolone on extracellular and tissue ionic shifts will be studied in the rat MCAo ..
  21. ONCOTIC PRESSURE AND EXTRAVASCULAR LUNG WATER IN ARDS
    Gregory Martin; Fiscal Year: 2004
    ..This investigational proposes a critical trial randomizing hypoproteinemic ARDS patients to albumin and furosemide or dual placebo with targeted goals of diuresis and weight loss...
  22. ASTROCYTE MEDIATED ETHANOL NEUROTOXICITY
    Michael Aschner; Fiscal Year: 2000
    ..swelling and EAA release during EtOH withdrawal can be attenuated by anion transport blockers (SITS, DIDS, furosemide, and L-644,711)...
  23. Levodopa Pharmokinetic Optimization by Metal Coordination
    Thomas Piccariello; Fiscal Year: 2009
    ..In rat studies, MCPs have been proven to favorably impact the PK of thyroid hormones (T3 and T4), furosemide and now, levodopa...
  24. FACTORS AFFECTING THE RENAL EXCRETION OF DRUGS
    Stephen Hall; Fiscal Year: 1992
    ..containing perfusate, will be employed to study the renal clearance of p- aminohippuric acid, chlorothiazide, furosemide and cefonicid...
  25. ANTINEOPLASTIC DRUG HEPATIC INTERACTIONS
    Dean Brenner; Fiscal Year: 1990
    ..aims include the: 1) use of bromobenzene or carbon tetrachloride to produce hepatic centrilobular lesions, furosemide to produce midzonal lesions, allyl formate to produce periportal lesions, and an hepatically implanted VX-2 ..
  26. ALPHA ADRENERGIC REGULATION OF THE VASCULAR NA+ PUMP
    Stephen Navran; Fiscal Year: 1992
    ..amiloride and its analogs to differentiate between Na+/Ca++ exchange and Na+/H+ exchange and the loop directors, furosemide and bumetamide, to identify Na+/K+/Cl- co transport...
  27. ROLE OF ION TRANSPORT RENAL CYST GROWTH
    William Macias; Fiscal Year: 1992
    ..To characterize the ion transport systems of cyst forming cells, activities will be measured in the presence of furosemide, ouabain, and amiloride...
  28. Function and High-Resolution of an APC superfamily amino acid transporter
    Bliss Forbush; Fiscal Year: 2009
    ..kidney another isoform, NKCC2, mediates salt absorption and is the site of action of the loop diuretic drugs furosemide and bumetanide...
  29. HYPERTENSION: PREDICTION OF BIOFEEDBACK SUCCESS
    Carolyn Yucha; Fiscal Year: 2002
    ..derived from five variables: heart rate, finger temperature, forehead muscle tension, plasma renin response to furosemide, and mean arterial pressure response to furosemide...
  30. SALT SENSITIVITY IN BLACKS:PHYSIOLOGIC & GENETIC STUDIES
    CLARENCE GRIM; Fiscal Year: 1993
    ..8.) To use molecular biological techniques to identify the chromosome subunits that hold the marker(s) for SS. These studies will lead to new ways to determine salt sensitivity in hypertensive patients...
  31. MOLECULAR PHYSIOLOGY AND STRUCTURE OF AQUAPORINS
    Alfred Van Hoek; Fiscal Year: 2002
    ..diversity and distinct roles of aquaporins, and may also facilitate the design of water channel diuretics or "aquaretic" agents that could induce a diuresis in situations where present diuretics, such as furosemide, are ineffective.
  32. ISOLATION OF THE GENE ENCODING THE NA-K-C1 COTRANSPORTER
    J Gargus; Fiscal Year: 1992
    ..The goal of this project in renewal remains to determine the nature of the membrane protein(s) responsible for the furosemide- sensitive Na-K-Cl cotransport system (fs system)...
  33. NERVE MUSCLE SYNAPSE FORMATION
    WILLIAM BETZ; Fiscal Year: 1992
    ..For example, with the Cl pump blocked with furosemide, we will measure the rate of decline of internal Cl concentration in end plate and extrajunctional regions when ..
  34. PRIOR HISTORY AND SALT INTAKE RATS
    Mary Florentine; Fiscal Year: 1993
    ..What are the mechanisms by which pregnancy and/or lactation result in increased need-free and need-induced salt intake?..
  35. CALCIUM AND SALT INTAKE
    MICHAEL TORDOFF; Fiscal Year: 1999
    ..e., during dietary iron or protein deficiency; reproduction; restraint; or treatment with furosemide or angiotensin-II)...
  36. REGULATION OF EXTRACELLULAR SPACE IN EPILEPTOGENESIS
    PHILIP SCHWARTZKROIN; Fiscal Year: 2000
    ..Finally, recent studies from the applicant's laboratory have shown that a commonly used diuretic, furosemide, is "anticonvulsant" in tests against a number of in vitro and in vivo models...
  37. MEMBRANE PERMEABILITY OF THE ASCITES TUMOR CELLS
    Felice Aull; Fiscal Year: 1980
    ..Experiments to determine the mechanism of action of furosemide will continue; this diuretic drug substantially inhibits one for one chloride exchange and its effect is partly ..
  38. Molecular Physiology of the Na-K-CI Cotransporter
    Bliss Forbush; Fiscal Year: 2007
    ..kidney another isoform, NKCC2, mediates salt absorption and is the site of action of the loop diuretic drugs furosemide and bumetanide...
  39. Neural Plasticity and Sensitization of Salt Appetite
    ILENE BERNSTEIN; Fiscal Year: 2007
    ..Behavioral and physiological manipulations will involve administration of the natriuretic/diuretic agent, furosemide to produce sodium depletion and promote a sodium appetite...
  40. Exploration of KCC2: Role in Schizophrenia
    JOEL GALLAGHER; Fiscal Year: 2004
    ..levels of protein expression of KCC2 while investigating its pharmacological manipulation with an antagonist, furosemide, in normal and c-PCP rats...
  41. MODULATION BY DISEASE OF EFFECT OF FUROSEMIDE IN MAN
    D Brater; Fiscal Year: 1980
    ..The pharmacodynamics of furosemide have been characterized in a group of normal subjects and it has been demonstrated that measures of drugs in ..
  42. Na-K-CI Cotransport in Pathogenesis of Airway Disease
    Beverly Koller; Fiscal Year: 2007
    ..This observation also suggests a molecular basis for previous reports showing that furosemide, an inhibitor of NKCC1, might be useful in the treatment of asthma...
  43. ACTIVE TRANSPORT IN EPITHELIA
    CHARLES STIRLING; Fiscal Year: 1980
    ..These drugs include cardioglycosides, for example, ouabain and the so-called high ceiling diuretics such a furosemide. The technique of high resolution quantitative autoradiography is used to localize these 3H-labeled drugs...
  44. DEVELOPMENTAL STUDIES OF COCHLEAR MECHANICS
    David Mills; Fiscal Year: 2003
    ..abstract_text> ..
  45. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
    ....
  46. Studies of cochlear mechanics: otoacoustic emissions
    Tianying Ren; Fiscal Year: 2005
    ..abstract_text> ..
  47. Third Symposium Cell Volume & Signalling Regulation
    PETER LAUF; Fiscal Year: 2003
    ..This meeting's success on U.S. soil will foster continuation of gathering of high-caliber scientists at subsequent international meetings ..
  48. Cue dependency with intravenous nutrients and nicotine
    Neil Rowland; Fiscal Year: 2007
    ..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
  49. CNS AND SALT APPETITE
    DOUGLAS FITTS; Fiscal Year: 2004
    ..The results will have implications for the central control of blood pressure and endocrine secretions as well as behavior during various challenges to body hydration. ..
  50. Physiology and genetics of food procurement in rodents
    Neil Rowland; Fiscal Year: 2008
    ..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
  51. C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    HAMID SAID; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. DEVELOPMENT OF TC-99M RENAL TUBULAR AGENTS
    Andrew Taylor; Fiscal Year: 2008
    ..abstract_text> ..
  53. Decision Support Systems for MAG3 Renography
    Andrew Taylor; Fiscal Year: 2005
    ..abstract_text> ..
  54. Mechanism/regulation of human intestinal thiamin uptake
    HAMID SAID; Fiscal Year: 2008
    ..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
  55. Inflammation & Prognosis in Decompensated Heart Failure
    GARY FELKER; Fiscal Year: 2008
    ..Felker's development into an established independent clinical investigator with expertise in both complex clinical research methodology and the role of inflammation in the pathophysiology of heart failure. ..