cefotaxime

Summary

Summary: Semisynthetic broad-spectrum cephalosporin.

Top Publications

  1. ncbi Darwinian evolution can follow only very few mutational paths to fitter proteins
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 312:111-4. 2006
  2. ncbi Predicting the emergence of antibiotic resistance by directed evolution and structural analysis
    M C Orencia
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Struct Biol 8:238-42. 2001
  3. pmc Quantifying the adaptive potential of an antibiotic resistance enzyme
    Martijn F Schenk
    Institute for Genetics, University of Cologne, Koln, Germany
    PLoS Genet 8:e1002783. 2012
  4. pmc Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-10) isolated in Spain
    A Oliver
    Servicio de Microbiologia, Hospital Ramon y Cajal, Madrid, Spain
    Antimicrob Agents Chemother 45:616-20. 2001
  5. pmc Longitudinal farm study of extended-spectrum beta-lactamase-mediated resistance
    E Liebana
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, Addlestone, Surrey KT153NB, United Kingdom
    J Clin Microbiol 44:1630-4. 2006
  6. pmc Enhancing the antibiotic antibacterial effect by sub lethal tellurite concentrations: tellurite and cefotaxime act synergistically in Escherichia coli
    Roberto C Molina-Quiroz
    Laboratorio de Microbiologia Molecular, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago de Chile, Chile
    PLoS ONE 7:e35452. 2012
  7. pmc Initial mutations direct alternative pathways of protein evolution
    Merijn L M Salverda
    Laboratory of Genetics, Department of Plant Sciences, Wageningen University, The Netherlands
    PLoS Genet 7:e1001321. 2011
  8. ncbi Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts
    Shimon Bershtein
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Mol Biol Evol 25:2311-8. 2008
  9. pmc Spread of Escherichia coli strains with high-level cefotaxime and ceftazidime resistance between the community, long-term care facilities, and hospital institutions
    Jesús Oteo
    Antibiotic Laboratory, Bacteriology Service, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera Pozuelo a Majadahonda, 28220 Majadahonda, Madrid, Spain
    J Clin Microbiol 44:2359-66. 2006
  10. pmc Clonally related Neisseria gonorrhoeae isolates with decreased susceptibility to the extended-spectrum cephalosporin cefotaxime in Amsterdam, the Netherlands
    Raymond Heymans
    Public Health Laboratory, Cluster of Infectious Diseases, Health Service of Amsterdam, The Netherlands
    Antimicrob Agents Chemother 56:1516-22. 2012

Research Grants

Detail Information

Publications216 found, 100 shown here

  1. ncbi Darwinian evolution can follow only very few mutational paths to fitter proteins
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 312:111-4. 2006
    ..This implies that the protein tape of life may be largely reproducible and even predictable...
  2. ncbi Predicting the emergence of antibiotic resistance by directed evolution and structural analysis
    M C Orencia
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Struct Biol 8:238-42. 2001
    ..coli-based directed evolution technique with cefotaxime selection...
  3. pmc Quantifying the adaptive potential of an antibiotic resistance enzyme
    Martijn F Schenk
    Institute for Genetics, University of Cologne, Koln, Germany
    PLoS Genet 8:e1002783. 2012
    ..Here, we study the distribution of mutation effects on cefotaxime (Ctx) resistance and fitness of 48 unique beneficial mutations in the bacterial enzyme TEM-1 β-lactamase, which ..
  4. pmc Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-10) isolated in Spain
    A Oliver
    Servicio de Microbiologia, Hospital Ramon y Cajal, Madrid, Spain
    Antimicrob Agents Chemother 45:616-20. 2001
    A cefotaxime-resistant, ceftazidime-susceptible Escherichia coli isolate was obtained from a patient with sepsis in 1997, from which a beta-lactamase with a pI of 8.1 was cloned...
  5. pmc Longitudinal farm study of extended-spectrum beta-lactamase-mediated resistance
    E Liebana
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, Addlestone, Surrey KT153NB, United Kingdom
    J Clin Microbiol 44:1630-4. 2006
    ..Escherichia coli isolates with resistance to a wide range of beta-lactams (including amoxicillin-clavulanate and cefotaxime) were isolated from scouring calves...
  6. pmc Enhancing the antibiotic antibacterial effect by sub lethal tellurite concentrations: tellurite and cefotaxime act synergistically in Escherichia coli
    Roberto C Molina-Quiroz
    Laboratorio de Microbiologia Molecular, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago de Chile, Chile
    PLoS ONE 7:e35452. 2012
    ..and clinical, uropathogenic Escherichia coli, especially with antibiotics disturbing the cell wall (ampicillin, cefotaxime) or protein synthesis (tetracycline, chloramphenicol, gentamicin)...
  7. pmc Initial mutations direct alternative pathways of protein evolution
    Merijn L M Salverda
    Laboratory of Genetics, Department of Plant Sciences, Wageningen University, The Netherlands
    PLoS Genet 7:e1001321. 2011
    ..the diversity of adaptive pathways among replicate lines during evolution for resistance to a novel antibiotic (cefotaxime)...
  8. ncbi Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts
    Shimon Bershtein
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Mol Biol Evol 25:2311-8. 2008
    ..in the population relieved from selection (Ohno's model) afforded only a narrow window of adaptation to cefotaxime (neofunctionalization)...
  9. pmc Spread of Escherichia coli strains with high-level cefotaxime and ceftazidime resistance between the community, long-term care facilities, and hospital institutions
    Jesús Oteo
    Antibiotic Laboratory, Bacteriology Service, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera Pozuelo a Majadahonda, 28220 Majadahonda, Madrid, Spain
    J Clin Microbiol 44:2359-66. 2006
    A total of 151 Escherichia coli strains resistant to cefotaxime and ceftazidime were isolated during a prospective surveillance study...
  10. pmc Clonally related Neisseria gonorrhoeae isolates with decreased susceptibility to the extended-spectrum cephalosporin cefotaxime in Amsterdam, the Netherlands
    Raymond Heymans
    Public Health Laboratory, Cluster of Infectious Diseases, Health Service of Amsterdam, The Netherlands
    Antimicrob Agents Chemother 56:1516-22. 2012
    ..gonorrhoeae isolates were identified with decreased susceptibility to the extended-spectrum cephalosporin (ESC) cefotaxime among visitors of the Amsterdam sexually transmitted infections (STI) clinic, the Netherlands...
  11. ncbi Isolates of β-lactamase-negative ampicillin-resistant Haemophilus influenzae causing invasive infections in Spain remain susceptible to cefotaxime and imipenem
    Silvia García-Cobos
    Antibiotic Laboratory, Servicio de Bacteriologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Antimicrob Chemother 69:111-6. 2014
    ..Our main goal was to determine whether invasive H. influenzae remains susceptible to β-lactam antibiotics indicated in the treatment of invasive infections...
  12. ncbi Empiric use of ampicillin and cefotaxime, compared with ampicillin and gentamicin, for neonates at risk for sepsis is associated with an increased risk of neonatal death
    Reese H Clark
    Pediatrix Obstetrix Center for Research and Education, Sunrise, Florida, USA
    Pediatrics 117:67-74. 2006
    ..As a result, we recommended that ampicillin and gentamicin be used as empiric coverage for early-onset neonatal sepsis while culture results are awaited...
  13. ncbi Emergence of CTX-M-type beta-lactam resistance in Shigella spp. in Hong Kong
    Terence Kin Man Cheung
    Int J Antimicrob Agents 25:350-2. 2005
  14. ncbi In situ ESBL conjugation from avian to human Escherichia coli during cefotaxime administration
    A Smet
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan, Merelbeke, Belgium
    J Appl Microbiol 110:541-9. 2011
    ..harbouring a bla(TEM-52) -carrying plasmid (lactose-negative mutant of B1-54, IncII group) was studied in an in situ continuous flow culture system, simulating the human caecum and the ascending colon during cefotaxime administration.
  15. pmc Cefotaxime-resistant Enterobacteriaceae isolates from a hospital in Warsaw, Poland: identification of a new CTX-M-3 cefotaxime-hydrolyzing beta-lactamase that is closely related to the CTX-M-1/MEN-1 enzyme
    M Gniadkowski
    Sera and Vaccines Central Research Laboratory, Warsaw, Poland
    Antimicrob Agents Chemother 42:827-32. 1998
    A group of cefotaxime-resistant Citrobacter freundii and Escherichia coli isolates were collected by a clinical laboratory in a hospital in Warsaw, Poland, in July 1996...
  16. ncbi Effects of cefotaxime and desacetylcefotaxime upon Clostridium difficile proliferation and toxin production in a triple-stage chemostat model of the human gut
    Jane Freeman
    Department of Microbiology, University of Leeds and The General Infirmary, Leeds LS2 9JT, UK
    J Antimicrob Chemother 52:96-102. 2003
    ..b>Cefotaxime (CTX) is well-known for its propensity to cause CDI, but the reasons behind its particular predisposition to the ..
  17. pmc Characteristics of cefotaxime-resistant Escherichia coli from wild birds in the Netherlands
    Kees Veldman
    Department of Bacteriology and TSEs, Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands
    Appl Environ Microbiol 79:7556-61. 2013
    ..Cloacal swabs from carcasses of Dutch wild birds obtained in 2010 and 2011 were selectively cultured on media with cefotaxime to screen for the presence of extended-spectrum β-lactamase (ESBL)/AmpC-producing Escherichia coli...
  18. pmc Cefotaxime-resistant bacteria colonizing older people admitted to an acute care hospital
    Robert A Bonomo
    Infectious Disease Section, Geriatric and Extended Care, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Am Geriatr Soc 51:519-22. 2003
    To determine the frequency of fecal colonization by cefotaxime-resistant gram-negative bacilli in older patients living in the community and in long-term care facilities (LTCFs) admitted to an acute care hospital.
  19. ncbi Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms
    Hisashi Yoshida
    Protein Design Laboratory, Yokohama City University, Suehiro 1 7 29, Tsurumi ku, Yokohama 230 0045, Japan
    J Mol Biol 423:351-64. 2012
    ..of penicillin-binding protein (PBP) 3 (PBP3) from MRSA, the apo form and a complex with the β-lactam antibiotic cefotaxime, and used electrospray mass spectrometry to measure its sensitivity to a variety of penicillin derivatives...
  20. pmc In vitro efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus
    Dong Min Kim
    Department of Laboratory Medicine, Chosun University Medical School, 588 Seoseok dong, Dong Gu, Gwang Ju 501 717, South Korea
    Antimicrob Agents Chemother 49:3489-91. 2005
    We performed time-kill studies of antimicrobial combinations that included minocycline, cefotaxime, and ciprofloxacin with Vibrio vulnificus ATCC 27562. Cefotaxime-plus-ciprofloxacin combinations acted synergistically against V...
  21. pmc Prevalence of fecal carriage of acquired expanded-spectrum cephalosporin resistance in Enterobacteriaceae strains from cattle in France
    Jean Yves Madec
    J Clin Microbiol 46:1566-7. 2008
  22. pmc Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime
    Silvia García-Cobos
    Antibiotic Laboratory, Bacteriology Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Antimicrob Agents Chemother 51:2564-73. 2007
    ..9%) and Arg517 to His (9.3%). Amino acid substitutions at positions 377, 385, and 389, which conferred cefotaxime and cefixime MICs 10 to 60 times higher than those of susceptible strains, were found for the first time in ..
  23. ncbi Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae
    Fereshteh Fani
    Centre de Recherche en Infectiologie du Centre de Recherche du CHUL and Département de Microbiologie, Infectiologie et Immunologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    J Antimicrob Chemother 68:1718-27. 2013
    To identify non-penicillin-binding protein (PBP) mutations contributing to resistance to the third-generation cephalosporin cefotaxime in Streptococcus pneumoniae at the genome-wide scale.
  24. pmc Concentration-dependent selection of small phenotypic differences in TEM beta-lactamase-mediated antibiotic resistance
    M C Negri
    Department of Microbiology, Ramon y Cajal Hospital, National Institute of Health INSALUD, Madrid, Spain
    Antimicrob Agents Chemother 44:2485-91. 2000
    ....
  25. ncbi In vitro activities of cefotaxime, vancomycin, quinupristin/dalfopristin, linezolid and other antibiotics alone and in combination against Propionibacterium acnes isolates from central nervous system infections
    Francine Mory
    Laboratoire de Bacteriologie virologie, UMR CNRS 7565, Faculte de Medecine, 54500 Vandoeuvre les Nancy, France
    J Antimicrob Chemother 55:265-8. 2005
    ..To evaluate the antibiotic susceptibilities of Propionibacterium acnes isolates from central nervous system (CNS) infections to agents used in current treatment regimens...
  26. ncbi In vitro efficacy of the combination of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotype Typhi
    Dong Min Kim
    Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Clinical Research Institute, Gwangju, South Korea
    Int J Antimicrob Agents 36:155-8. 2010
    ..Typhi (NASST) ATCC 9992 with ciprofloxacin, cefotaxime and azithromycin in various combinations. The combination of ciprofloxacin (0.012-0...
  27. ncbi Perioperative pharmacokinetics of cefotaxime in serum and bile during continuous and intermittent infusion in liver transplant patients
    S E Buijk
    Department of Surgery, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam
    J Antimicrob Chemother 54:199-205. 2004
    Drug pharmacokinetics may be altered during liver transplantation. Cefotaxime (CTX), used as perioperative prophylaxis, demonstrates time-dependent killing and therefore continuous infusion might have pharmacodynamic advantages.
  28. pmc Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance
    Angela Novais
    Hospital Universitario Ramon y Cajal, IMSALUD, Madrid, Spain
    Antimicrob Agents Chemother 52:2377-82. 2008
    CTX-M beta-lactamases, which show a high cefotaxime hydrolytic activity, constitute the most prevalent extended-spectrum beta-lactamase (ESBL) type found among clinical isolates...
  29. ncbi An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis
    Yupin Suputtamongkol
    Department of Medicine, Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 39:1417-24. 2004
    ..Although leptospirosis generally is susceptible to antibiotics, there is no consensus regarding the optimal treatment for severe leptospirosis...
  30. pmc Haemophilus influenzae bla(ROB-1) mutations in hypermutagenic deltaampC Escherichia coli conferring resistance to cefotaxime and beta-lactamase inhibitors and increased susceptibility to cefaclor
    Juan Carlos Galan
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Antimicrob Agents Chemother 47:2551-7. 2003
    ..submitted to serial passages in tubes containing broth with increasing concentrations of selected beta-lactams (cefotaxime or amoxicillin-clavulanate)...
  31. ncbi Dissemination of cefotaxime-M-producing Escherichia coli isolates in poultry farms, but not swine farms, in China
    Jingyun Li
    National Center for Surveillance of Antimicrobial Resistance, The State Food and Drug Administration, Chongwen District, Beijing, China
    Foodborne Pathog Dis 7:1387-92. 2010
    ..Of 56 ESBL-producing isolates, 54 isolates contained cefotaxime (CTX)-M type β-lactamases, including bla(CTX-M-14) (n = 24), bla(CTX-M-65) (n = 13), bla(CTX-M-55) (n = 10), ..
  32. pmc Enterococcus cecorum empyema thoracis successfully treated with cefotaxime
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 42:919-22. 2004
    ..The patient responded to cefotaxime (MIC, 0.25 microg/ml) treatment and drainage of the empyema. Susceptibility of E...
  33. ncbi Group B streptococci exposed to rifampin or clindamycin (versus ampicillin or cefotaxime) stimulate reduced production of inflammatory mediators by murine macrophages
    Kevin C Brinkmann
    Department of Pediatrics, University of Tennessee Health Science Center, Children s Foundation Research Center at Le Bonheur Children s Medical Center, Memphis, 38103, USA
    Pediatr Res 57:419-23. 2005
    ..We stimulated RAW 264.7 murine macrophages with a type-Ia GBS isolate in the presence of ampicillin, cefotaxime, rifampin, clindamycin, or gentamicin, singly or in combination...
  34. pmc In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila
    W C Ko
    Department of Internal Medicine, National Cheng Kung University Hospital, National Cheng Kung University Medical College, Tainan, Taiwan
    Antimicrob Agents Chemother 45:1281-3. 2001
    The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0...
  35. pmc Evaluation of cefotaxime and desacetylcefotaxime concentrations in cord blood after intrapartum prophylaxis with cefotaxime
    Jacques Lepercq
    Universite Paris Descartes, and Service de Gynécologie Obstétrique, Groupe Hospitalier Cochin Saint Vincent De Paul, 82, avenue Denfert Rochereau, Paris 75014, FranceParis, France
    Antimicrob Agents Chemother 53:2342-5. 2009
    ..coli. Our aim was to investigate whether a standardized dosage regimen of intrapartum cefotaxime could provide concentrations in the cord blood greater than the cefotaxime MIC(90) for E. coli...
  36. pmc A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 44:1936-42. 2000
    ..6 conferring a resistance phenotype characterized by a higher level of resistance to cefotaxime than to ceftazidime, as observed with the other CTX-M enzymes...
  37. pmc Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis
    Francisco José Pérez-Llarena
    Servicio de Microbiologia INIBIC, Complejo Hospitalario Universitario A Coruña, La Coruna, Spain
    Antimicrob Agents Chemother 55:4361-8. 2011
    ..Point mutations in CTX-M β-lactamases are considered critical for enhanced hydrolysis of cefotaxime. In order to clarify the structural determinants of the activity against cefotaxime in CTX-M β-lactamases, ..
  38. pmc Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coli
    Sara K Olofsson
    Antibiotic Research Unit, Department of Medical Sciences, Clinical Bacteriology and Infectious Diseases, Uppsala University, Sweden
    Antimicrob Agents Chemother 49:5081-91. 2005
    ..kinetic model was used to study the selection of two Escherichia coli strains with different susceptibilities to cefotaxime. The bacterial mixtures were exposed to cefotaxime for 24 h and SWs of 1, 2, 4, 8, and 12 h...
  39. pmc Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-9) from Escherichia coli in Spain
    M Sabate
    Departament de Microbiologia, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma 08025 Barcelona, Spain
    Antimicrob Agents Chemother 44:1970-3. 2000
    A new CTX-M-type beta-lactamase (CTX-M-9) has been cloned from a clinical cefotaxime-resistant Escherichia coli strain...
  40. ncbi The spread of CTX-M-type extended-spectrum beta-lactamases
    G M Rossolini
    Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Universita di Siena, Siena, Italy
    Clin Microbiol Infect 14:33-41. 2008
    ..CTX-M-type ESBLs exhibit powerful activity against cefotaxime and ceftriaxone but generally not against ceftazidime, which has important implications for laboratory detection...
  41. pmc Combining computational and experimental screening for rapid optimization of protein properties
    Robert J Hayes
    Xencor, 111 West Lemon Avenue, Monrovia, CA 91016, USA
    Proc Natl Acad Sci U S A 99:15926-31. 2002
    ..then constructed and experimentally screened to select for variants with improved resistance to the antibiotic cefotaxime. In a single round, we obtained variants exhibiting a 1,280-fold increase in resistance...
  42. pmc Continuous vs. intermittent cefotaxime administration in patients with chronic obstructive pulmonary disease and respiratory tract infections: pharmacokinetics/pharmacodynamics, bacterial susceptibility and clinical efficacy
    A R H van Zanten
    Department of Intensive Care, Gelderse Vallei Hospital, Ede, The Netherlands
    Br J Clin Pharmacol 63:100-9. 2007
    To compare the pharmacokinetics/pharmacodynamics, antibiotic resistance and clinical efficacy of continuous (CA) vs. intermittent administration (IA) of cefotaxime in patients with obstructive pulmonary disease and respiratory infections.
  43. pmc Atomic force microscopy: application to investigation of Escherichia coli morphology before and after exposure to cefodizime
    P C Braga
    Center for Respiratory Pharmacology, School of Medicine, University of Milan, Italy
    Antimicrob Agents Chemother 42:18-22. 1998
    ....
  44. pmc Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans
    M Muller
    Department of Clinical Pharmacology, University of Vienna, Austria
    Antimicrob Agents Chemother 40:2703-9. 1996
    ..This novel information may be useful for the rational development of dosage schedules and may improve predictions regarding therapeutic outcome...
  45. ncbi Nucleotide sequences of the pbpX genes encoding the penicillin-binding proteins 2x from Streptococcus pneumoniae R6 and a cefotaxime-resistant mutant, C506
    G Laible
    Max Planck Institut fur Molekulare Genetik, Berlin, FRG
    Mol Microbiol 3:1337-48. 1989
    ..PBP2x is one of the high-Mr PBPs which appears to be altered both in resistant clinical isolates, and in cefotaxime-resistant laboratory mutants...
  46. ncbi The impact of catheter-restricted filling with cefotaxime and heparin on the lifespan of temporary hemodialysis catheters: a case controlled study
    Anil K Saxena
    Division of Nephrology, Post Graduate Department of Medicine, King Fahad Hospital and Tertiary Care Center, King Faisal University, Eastern Province Saudi Arabia
    J Nephrol 18:755-63. 2005
    ..This study was designed to evaluate the impact of the "locking"' of a broad-spectrum antibiotic-cefotaxime with heparin, on the incidence of catheter thrombosis, catheter-related bloodstream infections (CRBSI) and the ..
  47. ncbi Typing and molecular characterization of Streptococcus pneumoniae with reduced susceptibility to cefotaxime isolated in Latin America
    Mariana Castanheira
    Laboratório Especial de Microbiologia Clínica, Disciplina de Doencas Infecciosas e Parasitarias, Universidade Federal de Sao Paulo, Brazil
    Microb Drug Resist 9:345-51. 2003
    ..The main objective of this study was to characterize isolates of S. pneumoniae with reduced susceptibility to cefotaxime (MICs, > or = 1 microg/ml) by different typing methods and to evaluate whether clonal dissemination of this ..
  48. ncbi Comparison of levofloxacin and cefotaxime combined with ofloxacin for ICU patients with community-acquired pneumonia who do not require vasopressors
    Olivier Leroy
    Service de Réanimation Médicale et Maladies Infectieuses, Hôpital G Chatiliez, 135 rue du Président Coty, 59208 Tourcoing, France
    Chest 128:172-83. 2005
    To evaluate the efficacy and tolerability of levofloxacin (L) as monotherapy in patients with severe community-acquired pneumonia (CAP) in comparison with therapy using a combination of cefotaxime (C) plus ofloxacin (O).
  49. pmc Lack of synergy of erythromycin combined with penicillin or cefotaxime against Streptococcus pneumoniae in vitro
    Eugene Lin
    Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701 3655, USA
    Antimicrob Agents Chemother 47:1151-3. 2003
    ..Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combinations in vitro act substantially as ..
  50. ncbi Ceftriaxone and cefotaxime use in Victorian hospitals
    Marion B Robertson
    Department of Clinical Pharmacology and Therapeutics, The Royal Melbourne Hospital, VIC 3050, Australia
    Med J Aust 176:524-9. 2002
    To determine patterns of use of ceftriaxone and cefotaxime (CEFX) in Victorian hospitals and to identify areas for improvement.
  51. ncbi Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes
    Michiyoshi Nukaga
    Department of Molecular and Cell Biology, The University of Connecticut, Storrs, Connecticut 06269 3125, USA
    J Biol Chem 279:9344-52. 2004
    ..freundii enzymes, the ES GC1 beta-lactamase is able to rapidly hydrolyze third-generation cephalosporins such as cefotaxime and ceftazidime...
  52. pmc Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro
    F Kuhn
    Department of Internal Medicine, Spital Bern Ziegler, Inselspital, Bern, Switzerland
    Antimicrob Agents Chemother 47:2487-91. 2003
    b>Cefotaxime, given in two doses (each 100 mg/kg of body weight), produced a good bactericidal activity (-0.47 Deltalog(10) CFU/ml. h) which was comparable to that of levofloxacin (-0.49 Deltalog(10) CFU/ml...
  53. ncbi [Cefotaxime, twenty years later. Observational study in critically ill patients]
    F Alvarez-Lerma
    Hospital del Mar, Barcelona
    Enferm Infecc Microbiol Clin 19:211-8. 2001
    OBJECTIVE: Afer twenty years of commercial availability of cefotaxime, the objective of this study was to know the reasons and modes of use, administration dosage as well as its effectiveness and tolerance in critically ill patients ..
  54. ncbi Plasmid-mediated resistance to ciprofloxacin and cefotaxime in clinical isolates of Salmonella enterica serotype Enteritidis in Hong Kong
    Terence Kin Man Cheung
    Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong SAR, China
    J Antimicrob Chemother 56:586-9. 2005
    To characterize the genetic determinants involved in the reduced susceptibility to ciprofloxacin and cefotaxime in Salmonella enterica serotype Enteritidis clinical isolates obtained from four patients in summer 2003 in Hong Kong.
  55. ncbi The combination effect of Korean red ginseng saponins with kanamycin and cefotaxime against methicillin-resistant Staphylococcus aureus
    Woo Sang Sung
    Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu, South Korea
    Biol Pharm Bull 31:1614-7. 2008
    ..To estimate the general combination effects of ginsenosides and commercial antibiotics, such as kanamycin and cefotaxime, on antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains that were ..
  56. pmc Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation
    Maurice J Ahsman
    Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, Netherlands
    Antimicrob Agents Chemother 54:1734-41. 2010
    ..b>Cefotaxime (CTX) is used to prevent and treat infections during ECMO, but the current dose regimen is based on ..
  57. ncbi Cefotaxime and ceftriaxone cerebrospinal fluid levels during treatment of bacterial meningitis in children
    Paul N Goldwater
    Microbiology and Infectious Diseases Department, Children, Youth and Women s Health Service, The Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Int J Antimicrob Agents 26:408-11. 2005
    b>Cefotaxime (CTX) and ceftriaxone (CRO) were compared for cerebrospinal fluid (CSF) penetration and antimicrobial efficacy in cases of bacterial meningitis in children...
  58. ncbi Ciprofloxacin-resistant typhoid with incomplete response to cefotaxime
    M R Prabha Adhikari
    Kasturba Medical College, Mangalore
    J Assoc Physicians India 50:428-9. 2002
  59. ncbi Efficacy and safety of cefotaxime in combination with metronidazole for empirical treatment of brain abscess in clinical practice: a retrospective study of 66 consecutive cases
    A K Jansson
    Department of Medical Sciences, Section of Infectious Diseases, Uppsala University Hospital, 751 85, Uppsala, Sweden
    Eur J Clin Microbiol Infect Dis 23:7-14. 2004
    ..patients with brain abscesses referred to a department of neurosurgery during a 10-year period and treated with cefotaxime were studied retrospectively by means of a prospectively designed protocol whose main areas of emphasis were ..
  60. ncbi Plasma and peritoneal concentration following continuous infusion of cefotaxime in patients with secondary peritonitis
    Philippe Seguin
    Service de Réanimation Chirurgicale Inserm U620, Universite Rennes 1, Hopital de Pontchaillou, Rennes Cedex 9, Rennes, France
    J Antimicrob Chemother 63:564-7. 2009
    The aim of this study was to determine the steady-state plasma and peritoneal concentrations of cefotaxime and its metabolite desacetyl-cefotaxime administered by continuous infusion to critically ill patients with secondary peritonitis.
  61. ncbi Trace analysis of cefotaxime at carbon paste electrode modified with novel Schiff base Zn(II) complex
    Preeti Nigam
    School of Biochemical Engineering, Institute of Technology, Banaras Hindu University, Varanasi, India
    Talanta 77:1426-31. 2009
    b>Cefotaxime a third generation cephalosporin drug estimation in nanomolar concentration range is demonstrated for the first time in aqueous and human blood samples using novel Schiff base octahedral Zn(II) complex...
  62. pmc CTX-M extended-spectrum beta-lactamases, Washington State
    Seonghan Kim
    Emerg Infect Dis 13:513-4. 2007
  63. ncbi Determination of cefotaxime and desacetylcefotaxime in cerebrospinal fluid by solid-phase extraction and high-performance liquid chromatography
    Jolanta J Bafeltowska
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Silesia, Jagiellonska 4, 41 200 Sosnowiec, Poland
    J Chromatogr A 976:249-54. 2002
    A high-performance liquid chromatographic procedure has been developed for the measurement of cefotaxime and desacetylcefotaxime in cerebrospinal fluid...
  64. ncbi Breakthrough in penicillin resistance? Streptococcus pneumoniae isolates with penicillin/cefotaxime MICs of 16 mg/L and their genotypic and geographical relatedness
    Francisco Soriano
    Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacion Jimenez Diaz, Madrid, Spain
    J Antimicrob Chemother 62:1234-40. 2008
    ..Nine isolates were from Romania (9/162; 5.56%) and two from Poland (2/305; 0.66%)...
  65. ncbi [Cefotaxime-resistant shiga toxin-producing Escherichia coli O26 : H11 isolated from a patient with diarrhea]
    Marina Kon
    Division of Clinical Microbiology, Saitama Institute of Public Health
    Kansenshogaku Zasshi 79:161-8. 2005
    A shiga toxin-producing Escherichia coli (STEC) O26 strain resistant to cefotaxime (CTX) and cefpodoxime (but not ceftazidime) was isolated from the faecal sample of a 17-year-old outpatient with diarrhea...
  66. ncbi Recurrent infections caused by cefotaxime- and ciprofloxacin-resistant Salmonella enterica serotype choleraesuis treated successfully with imipenem
    Shio Shin Jean
    Department of Critical Care Medicine and Internal Medicine, Min Sheng General Hospital, Taoyuan, Taiwan, ROC
    J Infect 51:e163-5. 2005
    ..case of recurrent infection (infective spondilitis, psoas abscess, and bacteraemia) caused by a single strain of cefotaxime- and ciprofloxacin-resistant and bla(CMY-2)-containing Salmonella enterica serotype choleraesuis during a 4-..
  67. ncbi Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin
    Tatsuro Shimamura
    Department of Biotechnology, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Biol Chem 277:46601-8. 2002
    ..We present the acyl-intermediate structures of Toho-1 in complex with cefotaxime (expanded-spectrum cephalosporin), cephalothin (non-expanded-spectrum cephalosporin), and benzylpenicillin at 1...
  68. ncbi Influence of penicillin/amoxicillin non-susceptibility on the activity of third-generation cephalosporins against Streptococcus pneumoniae
    A Fenoll
    Spanish National Reference Pneumococcal Laboratory, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220, Majadahonda, Madrid, Spain
    Eur J Clin Microbiol Infect Dis 27:75-80. 2008
    ..Penicillin-susceptible strains were susceptible to amoxicillin, cefotaxime and ceftriaxone, 99.8% to cefpodoxime and 99.5% to cefdinir, and were inhibited by 0...
  69. ncbi In vitro effects of cefotaxime and ceftriaxone on Salmonella typhi within human monocyte-derived macrophages
    B Ekinci
    Ondokuz Mayis University, Medical School, Dept Microbiology and Clin Microbiology, Samsun, Turkey
    Clin Microbiol Infect 8:810-3. 2002
    The main objective of this in vitro study was to assess the effects of cefotaxime and ceftriaxone in killing Salmonella typhi in infected human macrophages...
  70. pmc CTX-M-5, a novel cefotaxime-hydrolyzing beta-lactamase from an outbreak of Salmonella typhimurium in Latvia
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1980-4. 1998
    ..Transformants producing only the pI 8.8 beta-lactamase were resistant to cefotaxime and aztreonam but were susceptible or intermediate to ceftazidime...
  71. ncbi Synergistic antimicrobial effect of cefotaxime and minocycline on proinflammatory cytokine levels in a murine model of Vibrio vulnificus infection
    Shyh Ren Chiang
    Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan
    J Microbiol Immunol Infect 40:123-33. 2007
    ..This study aimed to evaluate the antimicrobial effect of cefotaxime and minocycline on proinflammatory cytokine levels in a murine model of V. vulnificus infection.
  72. ncbi Cost comparison of single daily i.v. doses of ceftriaxone versus continuous infusion of cefotaxime
    C M Hitt
    Hospital Pharmacy Services, Mayo Medical Center, Rochester, MN 55902, USA
    Am J Health Syst Pharm 54:1614-8. 1997
    ..administering ceftriaxone 1 g in a once-daily 30-minute infusion were compared with the costs of administering cefotaxime 2 g/day (with an additional 1 g given on day 1) by continuous intravenous infusion...
  73. pmc New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria
    Ines Schneider
    MICOER Institute, Munich, Germany
    Antimicrob Agents Chemother 53:4518-21. 2009
    ..This exchange decreased the hydrolytic activity of the beta-lactamase for cefotaxime, ceftazidime, and cefepime.
  74. ncbi Impregnation of vancomycin, gentamicin, and cefotaxime in a cement spacer for two-stage cementless reconstruction in infected total hip arthroplasty
    K H Koo
    Department of Orthopaedic Surgery and Cardiovascular Research Institute, Gyeong Sang National University School of Medicine, Chinju, South Korea
    J Arthroplasty 16:882-92. 2001
    ..using a cement spacer impregnated with a combination of 3 thermostable antibiotics (vancomycin, gentamicin, and cefotaxime). Initially, implants were removed, and a spacer was inserted...
  75. pmc A mutation in the D,D-carboxypeptidase penicillin-binding protein 3 of Streptococcus pneumoniae contributes to cefotaxime resistance of the laboratory mutant C604
    J Krauss
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Antimicrob Agents Chemother 41:936-42. 1997
    b>Cefotaxime resistance in laboratory mutant C604 of Streptococcus pneumoniae, for which the MIC is 1.5 microg/ml, is independent of alterations in high-molecular-mass penicillin-binding protein (PBP) 1a...
  76. pmc Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240-->Gly
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 45:2269-75. 2001
    ..The CTX-M-16-producing E. coli transformant exhibited the same level of resistance to cefotaxime (MIC, 16 microg/ml) but had a higher MIC of ceftazidime (MIC, 8 versus 1 microg/ml) than the CTX-M-9-producing ..
  77. pmc Altered PBP 2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniae
    Anthony M Smith
    MRC NICD WITS Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, P O Box 1038, Johannesburg 2000, South Africa
    Antimicrob Agents Chemother 49:2002-7. 2005
    ..Notably, compared to isolates 1 and 2, isolate 3 showed a decrease in penicillin, cefotaxime, and ceftriaxone resistance...
  78. ncbi Antimicrobial activity of isepamicin (SCH21420, 1-N-HAPA gentamicin B) combinations with cefotaxime, ceftazidime, ceftriaxone, ciprofloxacin, imipenem, mezlocillin and piperacillin tested against gentamicin-resistant and susceptible gram-negative bacilli
    R N Jones
    Department of Pathology, University of Iowa College of Medicine, Iowa City
    J Chemother 3:289-94. 1991
    ..The rank order of synergy (complete or partial) was; cefotaxime = ceftazidime = ceftriaxone = mezlocillin = piperacillin (75% to 80%) greater than imipenem (66%) greater than ..
  79. ncbi Oral ciprofloxacin versus intravenous cefotaxime and ceftriaxone in the treatment of spontaneous bacterial peritonitis
    Ilyas Tuncer
    Yuzuncu Yil University Medical Faculty, Department of Gastroenterology, 65300 Van, Turkey
    Hepatogastroenterology 50:1426-30. 2003
    b>Cefotaxime or ceftriaxone were considered the first-choice antibiotic for empirical treatment in cirrhotic patients developing spontaneous bacterial peritonitis...
  80. ncbi Modification of pharmacokinetics of cefotaxime in uranyl nitrate-induced renal damage in black bengal goats
    Biswa Priya Dutta
    Department of Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Mohanpur, Nadia, 741252, West Bengal, India
    J Vet Sci 5:1-3. 2004
    Pharmacokinetics of cefotaxime (50 mg/kg, i.m.) were studied in both healthy and kidney damaged female black Bengal goats. Uranyl nitrate (0...
  81. pmc SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients
    P A Bradford
    Lederle Laboratories, Pearl River, New York, USA
    Antimicrob Agents Chemother 39:899-905. 1995
    ..Strains MCQ-2, MCQ-3, and MCQ-4 were also noted to be resistant to cefotaxime. These three strains produced two beta-lactamases with pIs of 5.4 (TEM-1) and 7.6...
  82. ncbi Characterization of cefotaxime-resistant Escherichia coli isolates from a nosocomial outbreak at three geriatric hospitals
    Ling Ma
    Department of Microbiology, Toho University School of Medicine, 5 21 16 Omori nishi, Ota ku, Tokyo 143 8540, Japan
    J Infect Chemother 8:155-62. 2002
    Over a 22-month period, there was an unusual upsurge in the incidence of cefotaxime-resistant Escherichia coli among hospitalized patients in three geriatric hospitals in the same district...
  83. ncbi SHV-27, a novel cefotaxime-hydrolysing beta-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital
    J E Corkill
    Royal Liverpool University Hospital, Department of Medical Microbiology, Liverpool L7 8XP, UK
    J Antimicrob Chemother 47:463-5. 2001
    From a collection of cefotaxime-resistant Klebsiella pneumoniae isolated from neonatal blood culture specimens in a maternity hospital in Aracaju, Brazil, two isolates (strains KPBRZ-842 and -843, indistinguishable by pulsed-field gel ..
  84. ncbi Prevalence of clinical strains resistant to various beta-lactams in a tertiary care hospital in India
    Priya Datta
    Department of Microbiology, Govind Ballah Pant Hospital, New Delhi, India
    Jpn J Infect Dis 57:146-9. 2004
    ..e., ceftazidime, ceftriaxone, and cefotaxime, in order to screen for ESBL strains...
  85. ncbi Antimicrobial susceptibility of respiratory Haemophilus influenzae strains isolated from pediatric respiratory tract infections
    Luong Dong Cao
    Department of Pediatrics, Graduate School of Medicine Chiba University, Chiba, Japan
    Pediatr Int 46:419-24. 2004
    ..influenzae) is the most frequent bacterial pathogen of respiratory tract infections in children. Detection of antimicrobial susceptibility of H. influenzae is necessary for institution of appropriate antibiotic treatments...
  86. pmc Phenotypic and molecular detection of CTX-M-beta-lactamases produced by Escherichia coli and Klebsiella spp
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Pathology and Laboratory Medicine, University of Calgary, Alberta, Canada
    J Clin Microbiol 42:5715-21. 2004
    ..CTX-M-beta-lactamases are emerging around the world as a source of resistance to oxyiminocephalosporins such as cefotaxime (CTX). However, the laboratory detection of these strains is not well defined...
  87. ncbi [Antibiotic susceptibility and occurrence of ESBL in Pseudomonas aeruginosa strains isolated from different clinical specimens]
    Paweł Tomasz Sacha
    Zakład Diagnostyki Mikrobiologicznej Akademii Medycznej w Białymstoku
    Med Dosw Mikrobiol 56:263-73. 2004
    ..6%), amikacin (80.3%), meropenem and imipenem (81.8%). Many of our strains were resistant to cefotaxime (73.5%), ticarcillin (53%) and ciprofloxacin (48.5%)...
  88. ncbi Dissemination of transferable CTX-M-type extended-spectrum beta-lactamase-producing Escherichia coli in Korea
    S H Jeong
    Department of Laboratory Medicine and Graduate School of Public Health, Kosin University College of Medicine, Busan, Republic of Korea
    J Appl Microbiol 98:921-7. 2005
    Among 365 Escherichia coli isolated in 2003, 31 cefotaxime-resistant isolates were obtained from clinical specimens taken from adults hospitalized in Busan, Korea...
  89. pmc Practical methods using boronic acid compounds for identification of class C beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli
    Tetsuya Yagi
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    J Clin Microbiol 43:2551-8. 2005
    ..zone diameter (by greater than or equal to 5 mm) around a Kirby-Bauer disk containing a ceftazidime (CAZ) or a cefotaxime (CTX) disk in combination with APB...
  90. pmc Identification of CTX-M-14 {beta}-lactamase in a Salmonella enterica serovar enteritidis isolate from Japan
    Hidemasa Izumiya
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Antimicrob Agents Chemother 49:2568-70. 2005
    We analyzed the resistance to cefotaxime of a Salmonella enterica serovar Enteritidis isolate from a stool culture of a 4-year-old boy. It produced a beta-lactamase CTX-M-14, encoded by two related R plasmids...
  91. ncbi [Genotype of extended-spectrum beta-lactamases produced by antibiotic-resistant Escherichia coli and Klebsiella pneumoniae in surgical intensive care unit]
    Peng Yuan Wang
    Department of General Surgery, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 36:637-41. 2004
    ..coli.) and Klebsiella pneumoniae (KPn) in surgical intensive care unit(SICU), and to implore the molecular epidemiology of ESBLs coding genes of these strains...
  92. ncbi Detection of a novel variant bla(CTX-M-3) extended spectrum beta-lactamase gene in a community-acquired Escherichia coli isolate
    Spyros Pournaras
    Department of Medical Microbiology, University of Thessalia, Mezourlo, Larissa, Greece
    Scand J Infect Dis 38:213-6. 2006
    A highly cefotaxime- and cefepime-resistant but ceftazidime-sensitive Escherichia coli isolate was recovered from a community-acquired urinary infection of a Greek patient...
  93. pmc Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene
    David S Hammond
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Cnr Blamey St and Musk Ave, Kelvin Grove, Queensland 4059, Australia
    Antimicrob Agents Chemother 52:441-5. 2008
    ..of a non-extended-spectrum beta-lactamase (non-ESBL) encoding plasmid-borne form of bla(SHV) facilitates the cefotaxime (CTX)-mediated selection of ESBL-expressing mutants, even when there is a chromosomal copy of the same gene...
  94. ncbi Differences between ceftriaxone and cefotaxime: microbiological inconsistencies
    John G Gums
    Department of Pharmacy Practice, University of Florida, Gainesville, FL 32601, USA
    Ann Pharmacother 42:71-9. 2008
    To review data to determine why pneumococcal isolates appear to be increasingly resistant to cefotaxime, historically regarded as having the same in vitro susceptibility to ceftriaxone, and what this observation might imply clinically.
  95. ncbi Cefotaxime and ceftazidime-resistant Escherichia coli isolate producing TEM-15 beta-lactamase from a Tunisian hospital
    Chedly Chouchani
    Laboratoire de Biochimie et de Biotechnologie, Faculte des Sciences de Tunis, 2092 EL MANAR II, Tunisia
    C R Biol 330:565-70. 2007
    ..Analysis of this strain by the disk diffusion test revealed synergies between clavulanic acid and ceftazidime, cefotaxime. Clavulanic acid decreased the MICs of ceftazidime, cefotaxime, and ceftriaxone, which suggested that LBT04 ..
  96. pmc Dissemination of CTX-M-15 beta-lactamase genes carried on Inc FI and FII plasmids among clinical isolates of Escherichia coli in a university hospital in Istanbul, Turkey
    Nevriye Gonullu
    Department of Microbiology and Clinical Microbiology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul 34303, Turkey
    J Clin Microbiol 46:1110-2. 2008
    ..Plasmid typing of transconjugates carrying bla(CTX-M-15) showed that most isolates belonged to the Inc/rep FII group but that one isolate also belonged to the FI group...
  97. ncbi Emergence of CTX-M-12 extended-spectrum beta-lactamase-producing Escherichia coli in Korea
    Il Kwon Bae
    Department of Laboratory Medicine, Kosin University College of Medicine, 602 030, 34 Amnam dong, Suh gu, Busan, Korea
    J Antimicrob Chemother 58:1257-9. 2006
    ..To characterize CTX-M-12 extended-spectrum beta-lactamase (ESBL) produced by clinical Escherichia coli isolates and to investigate its genetic environment...
  98. ncbi An outbreak of extended spectrum beta-lactamase producing Klebsiella pneumoniae in a neonatal intensive care unit
    Shalini Shenoy
    Department of Microbiology, Kasturba Medical College, Mangalore
    Indian J Pathol Microbiol 50:669-70. 2007
    ..As neonates are at highest risk for acquisition of Klebsiella pneumoniae producing extended spectrum beta-lactamase, infection control policies and procedures should be strictly followed to prevent such outbreaks...
  99. ncbi [High effectiveness of the method with cefpirome in detection of extended-spectrum beta-lactamases in different species of gram-negative bacilli]
    Grazyna Młynarczyk
    Katedra i Zakład Mikrobiologii Lekarskiej AM w Warszawie
    Med Dosw Mikrobiol 58:59-65. 2006
    ..double-disc synergy diffusion test (DDST), and three tests of combined discs with cefpodoxime, ceftazidime and cefotaxime alone and the same cephalosporins with clavulanic acid...
  100. ncbi Surveillance of invasive Streptococcus pneumoniae in Taiwan, 2002-2003
    Ying Yan Chen
    Laboratory for Bacteriology and Mycology, Division of Laboratory Research and Development, Center for Disease Control, No 161, Kun Yang Street, Taipei, Taiwan
    J Med Microbiol 55:1109-14. 2006
    ..Most strains were susceptible to cephem drug, 85.7% of isolates were susceptible to cefotaxime and 92.9% were susceptible to ceftriaxone. A total of 72...
  101. ncbi [Antimicrobial susceptibility of phenotypically extended spectrum beta-lactamase producing Pseudomonas aeruginosa and Acinetobacter baumannii isolates]
    Gokhan Metan
    Erciyes Universitesi Tip Fakultesi, Enfeksiyon Hastaliklari ve Klinik Mikrobiyoloji Anabilim Dali, Kayseri
    Mikrobiyol Bul 40:23-8. 2006
    ..The susceptibilities of the isolates to ceftazidime, cefotaxime, cefepime, tobramycin, ciprofloxacin, piperacillin-tazobactam, imipenem and meropenem were determined by Etest (..

Research Grants7

  1. Challenges in beta-Lactamase Mediated Resistance
    Robert A Bonomo; Fiscal Year: 2013
    ..crystal structure of PDC-3 and the structure of PDC-3 complexed with BATSIs possessing ceftazidime (LP06) and cefotaxime R1 side chains...
  2. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  3. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
    ..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
  4. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  5. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Detection of Biofilm Bacteria using GloBac
    Robin Patel; Fiscal Year: 2008
    ..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
  7. EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODE
    David Nix; Fiscal Year: 2009
    ..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..