cephalosporins

Summary

Summary: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.

Top Publications

  1. ncbi Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection
    G Ralph Corey
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Clin Infect Dis 51:641-50. 2010
  2. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
  3. ncbi Nontyphoidal salmonellosis
    E L Hohmann
    Infectious Diseases Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 32:263-9. 2001
  4. pmc Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporins
    Vincent Dubée
    Centre de Recherche des Cordeliers, LRMA, Equipe 12, Universite Pierre et Marie Curie Paris 6, UMR S 872, Paris, France
    Antimicrob Agents Chemother 56:4189-95. 2012
  5. ncbi Impact of revised CLSI breakpoints for susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates in the Asia-Pacific region: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2002-2010
    Chi Chang Huang
    Department of Internal Medicine, National Cheng Kung University Hospital, No 138, Sheng Li Road, Tainan 704, Taiwan
    Int J Antimicrob Agents 40:S4-10. 2012
  6. ncbi High-level resistance to fluoroquinolones and cephalosporins in Burkholderia pseudomallei and closely related species
    Dimitry V Viktorov
    Research Institute for Plague Control, Golubinskaya st 7, 400131 Volgograd, Russia
    Trans R Soc Trop Med Hyg 102:S103-10. 2008
  7. ncbi Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella
    J J Rahal
    Department of Medicine, New York Hospital Medical Center of Queens and Cornell University Medical College, Flushing 11355, USA
    JAMA 280:1233-7. 1998
  8. ncbi Bacteremia due to extended-spectrum beta -lactamase-producing Escherichia coli in the CTX-M era: a new clinical challenge
    Jesús Rodríguez-Baño
    Sección de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Sevilla, 41071, Spain
    Clin Infect Dis 43:1407-14. 2006
  9. ncbi Control of extended-spectrum {beta}-lactamase-producing Klebsiella pneumoniae using a computer-assisted management program to restrict third-generation cephalosporin use
    Jeong Yeon Kim
    Division of Infectious Diseases, Korea University Medical Center, Seoul, Republic of Korea
    J Antimicrob Chemother 62:416-21. 2008
  10. ncbi Mutations in the ampC promoter of Escherichia coli isolates resistant to oxyiminocephalosporins without extended spectrum beta-lactamase production
    N Caroff
    Laboratoire de Bacteriologie virologie, Faculte de Pharmacie, Nantes, France
    FEMS Microbiol Lett 173:459-65. 1999

Detail Information

Publications370 found, 100 shown here

  1. ncbi Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection
    G Ralph Corey
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Clin Infect Dis 51:641-50. 2010
    ....
  2. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
    ..ESBLs) are a rapidly evolving group of beta-lactamases which share the ability to hydrolyze third-generation cephalosporins and aztreonam yet are inhibited by clavulanic acid...
  3. ncbi Nontyphoidal salmonellosis
    E L Hohmann
    Infectious Diseases Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 32:263-9. 2001
    ..The harbingers of resistance of nontyphoidal Salmonella to both fluoroquinolones and third-generation cephalosporins have been reported recently, and such resistance is likely to be a therapeutic problem in the future...
  4. pmc Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporins
    Vincent Dubée
    Centre de Recherche des Cordeliers, LRMA, Equipe 12, Universite Pierre et Marie Curie Paris 6, UMR S 872, Paris, France
    Antimicrob Agents Chemother 56:4189-95. 2012
    ..tuberculosis l,d-transpeptidase Ldt(Mt1) by carbapenems (meropenem, doripenem, imipenem, and ertapenem) and cephalosporins (cefotaxime, cephalothin, and ceftriaxone)...
  5. ncbi Impact of revised CLSI breakpoints for susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates in the Asia-Pacific region: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2002-2010
    Chi Chang Huang
    Department of Internal Medicine, National Cheng Kung University Hospital, No 138, Sheng Li Road, Tainan 704, Taiwan
    Int J Antimicrob Agents 40:S4-10. 2012
    This study examined the rates of susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates that had been obtained from patients with intraabdominal infections in the Asia-Pacific region as part of ..
  6. ncbi High-level resistance to fluoroquinolones and cephalosporins in Burkholderia pseudomallei and closely related species
    Dimitry V Viktorov
    Research Institute for Plague Control, Golubinskaya st 7, 400131 Volgograd, Russia
    Trans R Soc Trop Med Hyg 102:S103-10. 2008
    ..pseudomallei, B. mallei and B. thailandensis mutants with increased resistance to fluoroquinolones and cephalosporins were analysed. Resistance to pefloxacin, ofloxacin and ceftazidime in B. pseudomallei and B...
  7. ncbi Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella
    J J Rahal
    Department of Medicine, New York Hospital Medical Center of Queens and Cornell University Medical College, Flushing 11355, USA
    JAMA 280:1233-7. 1998
    ..Resistance to most or all cephalosporin antibiotics in Klebsiella species has developed in many European and North American hospitals during the past 2 decades...
  8. ncbi Bacteremia due to extended-spectrum beta -lactamase-producing Escherichia coli in the CTX-M era: a new clinical challenge
    Jesús Rodríguez-Baño
    Sección de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Sevilla, 41071, Spain
    Clin Infect Dis 43:1407-14. 2006
    ..Bacteremia caused by these organisms represents a clinical challenge, because the organisms are frequently resistant to the antimicrobials recommended for treatment of patients with suspected E. coli sepsis...
  9. ncbi Control of extended-spectrum {beta}-lactamase-producing Klebsiella pneumoniae using a computer-assisted management program to restrict third-generation cephalosporin use
    Jeong Yeon Kim
    Division of Infectious Diseases, Korea University Medical Center, Seoul, Republic of Korea
    J Antimicrob Chemother 62:416-21. 2008
    ..The aim of this study was to evaluate the control of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae and antimicrobial resistance through a computerized antibiotic control program...
  10. ncbi Mutations in the ampC promoter of Escherichia coli isolates resistant to oxyiminocephalosporins without extended spectrum beta-lactamase production
    N Caroff
    Laboratoire de Bacteriologie virologie, Faculte de Pharmacie, Nantes, France
    FEMS Microbiol Lett 173:459-65. 1999
    ..The +24 mutation was detected in another strain associated with a 1-bp insertion between the -35 and -10 conserved sequences. None of these mutations was detected in the ampC beta-lactamase from the sensitive isolates...
  11. pmc Genome sequencing of a Neisseria gonorrhoeae isolate of a successful international clone with decreased susceptibility and resistance to extended-spectrum cephalosporins
    David Hess
    Department of Biology, Santa Clara University, Santa Clara, California, USA
    Antimicrob Agents Chemother 56:5633-41. 2012
    The recent emergence of Neisseria gonorrhoeae strains with decreased susceptibility to extended-spectrum cephalosporins is a major concern globally. We sequenced the genome of an N...
  12. pmc Ceftiofur resistance in Salmonella enterica serovar Heidelberg from chicken meat and humans, Canada
    Lucie Dutil
    Public Health Agency of Canada, Saint Hyacinthe, Quebec, Canada
    Emerg Infect Dis 16:48-54. 2010
    ..To ensure the continued effectiveness of extended-spectrum cephalosporins for treating serious infections in humans, multidisciplinary efforts are needed to scrutinize and, where ..
  13. ncbi Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins
    Mandy Wootton
    NPHS Microbiology, University Hospital of Wales, Cardiff, UK
    J Antimicrob Chemother 65:79-81. 2010
    ..of Escherichia coli: (i) a selection of international isolates with mechanisms of resistance caused by the presence of defined beta-lactamases; and (ii) isolates resistant to third-generation cephalosporins referred from across Wales.
  14. pmc Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-9) from Escherichia coli in Spain
    M Sabate
    Departament de Microbiologia, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma 08025 Barcelona, Spain
    Antimicrob Agents Chemother 44:1970-3. 2000
    ..Outside of this region there are only six amino acids substitutions between both proteins...
  15. pmc Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence
    Yu Kuo Tsai
    Division of Infectious Diseases, National Health Research Institutes, Miaoli, Taiwan
    Antimicrob Agents Chemother 55:1485-93. 2011
    ..01) lower virulence, whereas the ΔompK35/36 mutant presented the highest 50% lethal dose of these strains. In conclusion, porin deficiency in K. pneumoniae could increase antimicrobial resistance but decrease virulence at the same time...
  16. pmc Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics
    Adriel Villegas-Estrada
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Am Chem Soc 130:9212-3. 2008
    ..These compounds are potent inhibitors of PBP 2a as well as PBPs from other species, and have potential as therapeutic agents for treatment of serious infections by MRSA and other resistant bacterial pathogens...
  17. pmc Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion
    J W Mouton
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Hospital Rotterdam, The Netherlands
    Antimicrob Agents Chemother 41:733-8. 1997
    ..Application of these models will eventually provide us with parameters which can be used for further dosage optimization...
  18. ncbi Efficacy of cefditoren pivoxil and amoxicillin/clavulanate in the treatment of pediatric patients with acute bacterial rhinosinusitis in Thailand: a randomized, investigator-blinded, controlled trial
    Orapan Poachanukoon
    Department of Pediatrics, Faculty of Medicine, Thammasat University, Prathumthani, Thailand
    Clin Ther 30:1870-9. 2008
    The recommended treatment for acute bacterial rhinosinusitis in adults and children is 10 to 14 days of high doses of oral cephalosporins or amoxicillin/clavulanate.
  19. pmc Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998
    A Carattoli
    Laboratory of Bacteriology and Mycology, Istituto Superiore di Sanita, 00161 Rome, Italy
    Antimicrob Agents Chemother 46:1269-72. 2002
    ..These data suggest that the spread of cmy-2 among Salmonella strains is occurring through mobilization of the cmy-2 gene into different plasmid backbones and consequent horizontal transfer by conjugation...
  20. pmc Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum beta-lactamases: implications for the clinical microbiology laboratory
    D L Paterson
    Infectious Disease Division, University of Pittsburgh VA Medical Center, University Dr. C, Pittsburgh, PA 15240, USA
    J Clin Microbiol 39:2206-12. 2001
    ..ESBLs) hydrolyze cephalosporin antibiotics, some ESBL-producing organisms are not resistant to all cephalosporins when tested in vitro...
  21. pmc Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae
    L Martinez-Martinez
    Department of Microbiology, School of Medicine, University of Seville, Seville, Spain
    Antimicrob Agents Chemother 43:1669-73. 1999
    ..In K. pneumoniae porin loss can thus augment resistance provided either by TEM- or SHV-type ESBLs or by plasmid-mediated AmpC enzymes to include the latest oxyimino-beta-lactams and carbapenems...
  22. pmc Phase 2 study of ceftaroline versus standard therapy in treatment of complicated skin and skin structure infections
    George H Talbot
    Cerexa Inc, Alameda, CA 94502, USA
    Antimicrob Agents Chemother 51:3612-6. 2007
    ..3%). Ceftaroline exhibited a very favorable safety and tolerability profile, consistent with that of marketed cephalosporins. Most adverse events from ceftaroline were mild and not related to treatment...
  23. pmc Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
    Helio S Sader
    JMI Laboratories, Inc, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 49:3501-12. 2005
    ..bacteria, particularly against multidrug-resistant staphylococci and streptococci of current clinical concern, than currently available extended-spectrum cephalosporins while maintaining similar activity against gram-negative pathogens.
  24. ncbi Burden of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay associated with bloodstream infections due to Escherichia coli resistant to third-generation cephalosporins
    M E A de Kraker
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands
    J Antimicrob Chemother 66:398-407. 2011
    ..This study determined excess mortality and length of hospital stay (LOS) attributable to bloodstream infection (BSI) caused by third-generation-cephalosporin-resistant Escherichia coli in Europe...
  25. pmc Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009
    Supriya D Mehta
    Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60622, USA
    Antimicrob Agents Chemother 55:3882-8. 2011
    ..High levels of plasmid-mediated resistance and increasing MICs for cephalosporins suggest that selective pressure from antibiotic use is a strong driver of resistance emergence.
  26. ncbi Abundance and phenotypic diversity of Escherichia coli isolates with diminished susceptibility to expanded-spectrum cephalosporins in faeces from healthy food animals after slaughter
    Miguel A Moreno
    Grupo de Vigilancia Sanitaria VISAVET, Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Vet Microbiol 120:363-9. 2007
    ..is applied to test for phenotypic diversity associated with diminished susceptibility to expanded-spectrum cephalosporins (DSESC) in faecal Escherichia coli from healthy food animals in Spain. We performed E...
  27. ncbi Trends in resistance to carbapenems and third-generation cephalosporins among clinical isolates of Klebsiella pneumoniae in the United States, 1999-2010
    Nikolay P Braykov
    Center for Disease Dynamics, Economics and Policy, Washington, DC 20036, USA
    Infect Control Hosp Epidemiol 34:259-68. 2013
    ..We examined national trends in the proportion of Klebsiella pneumoniae isolates resistant to carbapenems (CRKP) and third-generation cephalosporins (G3CRKP).
  28. ncbi Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation
    Gulay Ozcengiz
    Middle East Technical University, Dumlupinar Bulv, 06800 Ankara, Turkey
    Biotechnol Adv 31:287-311. 2013
    ..Sales of these remarkable compounds have reached over $20 billion dollars per year. They include penicillins, cephalosporins, cefoxitin, monobactams, clavulanic acid and carbapenems...
  29. ncbi Quantification of the bla(CMY-2) in feces from beef feedlot cattle administered three different doses of ceftiofur in a longitudinal controlled field trial
    W Q Alali
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, USA
    Foodborne Pathog Dis 6:917-24. 2009
    ....
  30. pmc Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States
    Bashar W Shaheen
    Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Antimicrob Agents Chemother 55:5666-75. 2011
    Resistance to extended-spectrum cephalosporins (ESC) among members of the family Enterobacteriaceae occurs worldwide; however, little is known about ESC resistance in Escherichia coli strains from companion animals. Clinical isolates of E...
  31. ncbi Reduction in colonization and nosocomial infection by multiresistant bacteria in a neonatal unit after institution of educational measures and restriction in the use of cephalosporins
    R Calil
    Neonatal Unit of the Pediatric Department, Faculty of Medical Sciences, State University of Campinas, , Brazil
    Am J Infect Control 29:133-8. 2001
    INTRODUCTION: Previous administration of third-generation cephalosporins predisposes to colonization and infections by multiresistant Enterobacter sp...
  32. ncbi Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258
    S Breurec
    Institut Pasteur, Dakar, Senegal
    Clin Microbiol Infect 19:349-55. 2013
    ..These results have major implications for patient management and highlight a potential reservoir for resistance determinants...
  33. ncbi Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem
    Dale N Gerding
    Clin Infect Dis 38:646-8. 2004
  34. ncbi Ceftriaxone-resistant salmonella infection acquired by a child from cattle
    P D Fey
    Nebraska Public Health Laboratory, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 5400, USA
    N Engl J Med 342:1242-9. 2000
    ..We analyzed the molecular characteristics of a ceftriaxone-resistant strain of Salmonella enterica serotype typhimurium isolated from a 12-year-old boy with fever, abdominal pain, and diarrhea...
  35. ncbi Diagnosing hypersensitivity reactions to cephalosporins in children
    Antonino Romano
    Unità di Allergologia, Complesso Integrato Columbus, Via G Moscati, 31, 00168 Rome, Italy
    Pediatrics 122:521-7. 2008
    The goals were to evaluate the usefulness of skin tests, patch tests, serum specific IgE assays, and challenges in diagnosing hypersensitivity reactions to cephalosporins and to clarify the pathogenic mechanism of such reactions.
  36. ncbi Cefepime-resistant Gram-negative bacteremia in febrile neutropenic patients with hematological malignancies
    Yong Chong
    Department of Blood and Marrow Transplantation, Hara Sanshin Hospital, 1 8 Taihaku cho, Hakata Ku, Fukuoka, Japan
    Int J Infect Dis 14:e171-5. 2010
    ..This study was performed to determine the local etiologic pattern of blood culture isolates and antibiotic resistance in febrile neutropenic patients with hematological malignancies...
  37. pmc Role of ceftiofur in selection and dissemination of blaCMY-2-mediated cephalosporin resistance in Salmonella enterica and commensal Escherichia coli isolates from cattle
    Joshua B Daniels
    Department of Veterinary Microbiology and Pathology, Washington State University College of Veterinary Medicine, Pullman, WA 99164, USA
    Appl Environ Microbiol 75:3648-55. 2009
    ..coli and in pathogenic Salmonella in these dairy cattle populations...
  38. pmc Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves
    Sarah C Donaldson
    Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
    Appl Environ Microbiol 72:3940-8. 2006
    ..coli shortly after birth. The high prevalence of multidrug-resistant nonpathogenic E. coli in calves could be a significant source of resistance genes to other bacteria that share the same environment...
  39. ncbi Review of resistance of ocular isolates of Pseudomonas aeruginosa and staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins
    Mark D P Willcox
    School of Optometry and Vision Science, University of New South Wales, Sydney NSW 2052, Australia
    Clin Exp Optom 94:161-8. 2011
    ..Antibiotic therapy to treat keratitis caused by these bacteria is either monotherapy with a fluoroquinolone or combination therapy with fortified gentamicin...
  40. ncbi The complex clinical picture of beta-lactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems, and clavams
    Maria J Torres
    Allergy Service, Plaza del Hospital Civil, Pabellón 5 Sótano, Carlos Haya Hospital, Pabellon C, Malaga 29009, Spain
    Med Clin North Am 94:805-20, xii. 2010
    ..The natural history of IgE-mediated reactions indicates that the count of specific IgE antibodies decreases over time and that results of diagnostic tests can become negative...
  41. ncbi Update of cefditoren activity tested against community-acquired pathogens associated with infections of the respiratory tract and skin and skin structures, including recent pharmacodynamic considerations
    Douglas J Biedenbach
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 64:202-12. 2009
    ..and Latin America and Europe were tested to confirm cefditoren potency and spectrum compared with other oral cephalosporins and other class agents...
  42. ncbi Variations in the prevalence of strains expressing an extended-spectrum beta-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific region
    P L Winokur
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 32:S94-103. 2001
    ..P. mirabilis and E. coli strains for which MICs of extended-spectrum cephalosporins or monobactams were elevated also were more prominent in Latin America...
  43. ncbi AmpC beta-lactamase producing bacterial isolates from Kolkata hospital
    Suranjana Arora
    Section of Microbiology, Department of Physiology, University of Calcutta, University College of Science and Technology, Kolkata, India
    Indian J Med Res 122:224-33. 2005
    ..Information on such pathogens is not available from eastern region of India. This study was undertaken to determine the AmpC beta-lactamase production in pathogens isolated from hospitalized patients in Kolkata...
  44. ncbi Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens
    Yvonne Pfeifer
    Robert Koch Institute, Nosocomial Infections, Wernigerode Branch, Burgstr 37, 38855 Wernigerode, Germany
    Int J Med Microbiol 300:371-9. 2010
    ..Especially the increasing resistance to 3rd and 4th generation cephalosporins and carbapenems is of particular concern...
  45. ncbi Association between ceftiofur use and isolation of Escherichia coli with reduced susceptibility to ceftriaxone from fecal samples of dairy cows
    Lesley A Tragesser
    Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Vet Res 67:1696-700. 2006
    ..To estimate the association between ceftiofur use and the isolation of Escherichia coli with reduced ceftriaxone susceptibility from fecal samples of dairy cow populations...
  46. ncbi CANVAS 1: the first Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections
    G Ralph Corey
    Division of Infectious Diseases, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    J Antimicrob Chemother 65:iv41-51. 2010
    ....
  47. ncbi Analysis of fecal microbial flora for antibiotic resistance in ceftiofur-treated calves
    Xiuping Jiang
    Department of Food Science and Human Nutrition, Clemson University, Clemson, South Carolina 29634, USA
    Foodborne Pathog Dis 3:355-65. 2006
    ..Treatment of calves with therapeutic dosages of ceftiofur can significantly increase for at least 17 days following the initial treatment the fecal excretion of ceftriaxone-resistant bacteria, including Salmonella species...
  48. ncbi Integrated safety summary of CANVAS 1 and 2 trials: Phase III, randomized, double-blind studies evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections
    Michael L Corrado
    INC Research, New Hope, PA 18938, USA
    J Antimicrob Chemother 65:iv67-iv71. 2010
    ..This report provides an integrated safety summary of the CeftAroliNe Versus VAncomycin in Skin and Skin Structure Infections (CANVAS) 1 and 2 studies (registration numbers NCT00424190 and NCT00423657)...
  49. pmc In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae
    Lesley McGee
    Emory University, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 53:552-6. 2009
    Increasing pneumococcal resistance to extended-spectrum cephalosporins warrants the search for novel agents with activity against such resistant strains...
  50. pmc OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, Le Kremlin Bicêtre 94275, France
    Antimicrob Agents Chemother 55:2546-51. 2011
    ..This study identified the first class D β-lactamase compromising both extended-spectrum cephalosporin and carbapenem activities...
  51. ncbi Phenotypic detection of extended-spectrum and AmpC beta-lactamases by a new spot-inoculation method and modified three-dimensional extract test: comparison with the conventional three-dimensional extract test
    M Shahid
    Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
    J Antimicrob Chemother 54:684-7. 2004
    ....
  52. ncbi Treatment of ESBL-producing Klebsiella pneumoniae bacteraemia with carbapenems or flomoxef: a retrospective study and laboratory analysis of the isolates
    Chen Hsiang Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, College of Medicine, Taiwan
    J Antimicrob Chemother 58:1074-7. 2006
    ....
  53. pmc The LisRK signal transduction system determines the sensitivity of Listeria monocytogenes to nisin and cephalosporins
    Paul D Cotter
    Department of Microbiology and National Food Biotechnology Centre, University College Cork, Cork, Ireland
    Antimicrob Agents Chemother 46:2784-90. 2002
    ..displays significantly enhanced resistance to the lantibiotic nisin, a greatly enhanced sensitivity to the cephalosporins, and a large reduction in the expression of three genes thought to encode a penicillin-binding protein, ..
  54. ncbi Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase
    J Spencer
    Department of Pathology and Microbiology, University of Bristol School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 276:33638-44. 2001
    ....
  55. ncbi CANVAS 2: the second Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections
    Mark H Wilcox
    Department of Microbiology, Leeds Teaching Hospitals and University of Leeds, Leeds, UK
    J Antimicrob Chemother 65:iv53-iv65. 2010
    ....
  56. ncbi Risk factors for ceftiofur resistance in Escherichia coli from Belgian broilers
    D Persoons
    Department of Obstetrics, Reproduction and Herd Health, Veterinary Epidemiology Unit, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Epidemiol Infect 139:765-71. 2011
    ..This study confirms that not only on-farm antimicrobial therapy, but also management- and hatchery-related factors influence the occurrence of antimicrobial resistance...
  57. pmc High-level expression of ampC beta-lactamase due to insertion of nucleotides between -10 and -35 promoter sequences in Escherichia coli clinical isolates: cases not responsive to extended-spectrum-cephalosporin treatment
    L K Siu
    Division of Clinical Research, National Health Research Institutes, National Taiwan University Hospital, Taipei, Taiwan
    Antimicrob Agents Chemother 47:2138-44. 2003
    ..promoter sequences was the mechanism for the hyperproduction of AmpC beta-lactamase and resistance to oxyimino-cephalosporins. The failure of the two patients to respond to treatment with oxyimino-cephalosporins highlights the important ..
  58. pmc Novel plasmid-mediated beta-lactamase from Escherichia coli that inactivates oxyimino-cephalosporins
    Y Matsumoto
    Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Osaka, Japan
    Antimicrob Agents Chemother 32:1243-6. 1988
    ..Of the oxyimino-cephalosporins, ceftizoxime was fairly stable to FEC-1. FEC-1 differed notably from chromosomal E...
  59. pmc Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae
    K Kosowska-Shick
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 54:1670-7. 2010
    ..1 to 4 microg/ml) for PBP2X, -2A, -2B, and -3 than those for the other cephalosporins tested. Among 3 penicillin-resistant S...
  60. ncbi Efficacy and safety of cefepime: a systematic review and meta-analysis
    Dafna Yahav
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    Lancet Infect Dis 7:338-48. 2007
    ..This Review provides evidence and offers possible explanations for increased mortality among patients treated with cefepime in randomised trials...
  61. ncbi Pharmacokinetics of ceftazidime and cefepime in burn patients: the importance of age and creatinine clearance
    J M Conil
    Service d Anesthesie Reanimation, Hopital de Rangueil, Toulouse, France
    Int J Clin Pharmacol Ther 45:529-38. 2007
    ....
  62. ncbi Population pharmacokinetics and pharmacodynamics of cefpirome in critically ill patients against Gram-negative bacteria
    Juliana F Roos
    School of Pharmacy, University of Queensland, 4072, Brisbane, QLD, Australia
    Intensive Care Med 33:781-8. 2007
    ..MIC distribution of likely ICU pathogens, and to assess their expected cumulative fraction of response (CFR)...
  63. pmc Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modeling indicates improved troughs with revised dosing
    J Lipman
    Division of Anaesthesiology and Intensive Care, University of Queensland, Queensland, Australia
    Antimicrob Agents Chemother 43:2559-61. 1999
    ..Computer simulations predicted that continuous infusion and shorter dosing intervals would increase trough levels...
  64. ncbi Low cefpirome levels during twice daily dosing in critically ill septic patients: pharmacokinetic modelling calls for more frequent dosing
    J Lipman
    Royal Brisbane Hospital, Herston 4029, Brisbane, Queensland, Australia
    Intensive Care Med 27:363-70. 2001
    ..To use the pharmacokinetic model to simulate alternate dosing regimens and identify those that predict sustained levels...
  65. ncbi Pharmacokinetics of ceftazidime in serum and peritoneal exudate during continuous versus intermittent administration to patients with severe intra-abdominal infections
    S L C E Buijk
    Department of Surgical Intensive Care, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Antimicrob Chemother 49:121-8. 2002
    ..60% of the concomitant serum AUCs. In critically ill surgical patients with severe IAIs, CI of ceftazidime resulted in more favourable concentrations in serum and peritoneal exudate than 8-hourly bolus infusion...
  66. pmc Antibiotic prophylaxis using third generation cephalosporins can reduce the risk of early rebleeding in the first acute gastroesophageal variceal hemorrhage: a prospective randomized study
    Chung Hwan Jun
    Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
    J Korean Med Sci 21:883-90. 2006
    ..The aim of the study was to compare prophylactic third generation cephalosporins with on-demand antibiotics for the prevention of gastroesophageal variceal rebleeding...
  67. ncbi Five-day oral cefditoren pivoxil versus 10-day oral amoxicillin for pediatric group A streptococcal pharyngotonsillitis
    Takao Ozaki
    Department of Pediatrics, Konan Kosci Hospital, 137 Ohmatsubara, Takaya cho, Konan, Aichi 483 8704, Japan
    J Infect Chemother 14:213-8. 2008
    ..Because the efficacy for pediatric group A streptococcus pharyngotonsillitis was similar between oral cefditoren-pivoxil for 5 days and amoxicillin for 10 days, the shorter treatment period may make the former regimen preferable...
  68. ncbi Impact of antibiotic restriction on broad spectrum antibiotic usage in the ICU of a developing country
    Shahla Siddiqui
    Department of Anaesthesia, Aga Khan University, Karachi
    J Pak Med Assoc 57:484-7. 2007
    ..To reduce rates of nosocomial pneumonia and cost of antibiotic therapy...
  69. ncbi Neisseria gonorrhoeae and emerging resistance to extended spectrum cephalosporins
    John W Tapsall
    World Health Collaborating Centre for STDs, Department of Microbiology, The Prince of Wales Hospital, Sydney, Australia
    Curr Opin Infect Dis 22:87-91. 2009
    ..Considerable reliance is now placed on third-generation cephalosporins for the treatment of gonorrhoea following the loss of efficacy of penicillins and quinolones...
  70. pmc In vitro activity of ceftaroline against methicillin-resistant Staphylococcus aureus and heterogeneous vancomycin-intermediate S. aureus in a hollow fiber model
    Celine Vidaillac
    Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
    Antimicrob Agents Chemother 53:4712-7. 2009
    ..Although further in vitro and in vivo investigations are warranted, ceftaroline appears to be a promising alternative for the treatment of MRSA infections...
  71. ncbi Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E(2) across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins
    Shin ichi Akanuma
    Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    J Pharmacol Exp Ther 333:912-9. 2010
    ....
  72. ncbi Cephalosporins in veterinary medicine - ceftiofur use in food animals
    Rex E Hornish
    Pharmacia Animal Health, Pharmacia Corp, 7000 Portage Road, Kalamazoo, MI 49001, USA
    Curr Top Med Chem 2:717-31. 2002
    b>Cephalosporins are an important class of antibacterial agents in use today for both humans and animals. Four generations of cephalosporins have evolved, all of which contain the beta-lactam sub-structure first found in penicillin...
  73. pmc Community-acquired versus nosocomial Klebsiella pneumoniae bacteremia: clinical features, treatment outcomes, and clinical implication of antimicrobial resistance
    Cheol In Kang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 21:816-22. 2006
    ..Antimicrobial resistance was a widespread nosocomial problem and also identified in community-acquired infections...
  74. pmc The use of cephalosporins for gonorrhea: the impending problem of resistance
    Pennan M Barry
    University of California San Francisco, San Francisco Department of Public Health, San Francisco, CA 94103, USA
    Expert Opin Pharmacother 10:555-77. 2009
    ..This has now left third-generation cephalosporins as the lone class of antimicrobials recommended as first-line therapy for gonorrhea in some regions...
  75. pmc Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations
    Joshua Tomberg
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
    Biochemistry 49:8062-70. 2010
    ..2 (PBP 2) encoded by mosaic penA alleles are crucial for intermediate resistance to the expanded-spectrum cephalosporins ceftriaxone and cefixime in Neisseria gonorrhoeae...
  76. ncbi Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humans
    James R Johnson
    Medical Service, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    J Infect Dis 188:759-68. 2003
    ..Thus, in E. coli, antibiotic resistance predicts phylogenetic background and virulence potential in a complex, context-dependent fashion...
  77. pmc In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States
    Yigong Ge
    Cerexa, Inc, Alameda, California, USA
    Antimicrob Agents Chemother 52:3398-407. 2008
    ..Ceftaroline was very potent against bacteria found in community- and hospital-acquired infections, including methicillin-resistant Staphylococcus aureus, multidrug-resistant Streptococcus pneumoniae, and common Enterobacteriaceae spp...
  78. pmc Replacement of broad-spectrum cephalosporins by piperacillin-tazobactam: impact on sustained high rates of bacterial resistance
    Carlos Bantar
    Committee for Prevention and Control of Nosocomial Infection, Hospital San Martin, Parana, Entre Rios, Argentina
    Antimicrob Agents Chemother 48:392-5. 2004
    ..associated with an increase in the use of cefepime, along with a decrease in the consumption of broad-spectrum cephalosporins (CEP). However, we did not observe such a reduction with Klebsiella pneumoniae...
  79. ncbi Cefepime versus cefpirome: the importance of creatinine clearance
    Jeffrey Lipman
    Intensive Care Unit, Royal Brisbane Hospital, Herston, Queensland, Australia
    Anesth Analg 97:1149-54, table of contents. 2003
    ..We compared the pharmacokinetics of two fourth-generation cephalosporins, cefepime and cefpirome, and examined the relationship of drug clearance (CL) to creatinine clearance (CL(CR))...
  80. ncbi Continuous infusion ceftazidime in intensive care: a randomized controlled trial
    J Lipman
    Royal Brisbane Hospital, Division of Anaesthesiology and Intensive Care, University of Queensland, Brisbane, Australia
    J Antimicrob Chemother 43:309-11. 1999
    ..The pharmacokinetic and pharmacodynamic characteristics of ceftazidime suggest that continuous infusions should be clinically investigated in outcome studies...
  81. pmc Diversity of extended-spectrum beta-lactamases and class C beta-lactamases among cloacal Escherichia coli Isolates in Belgian broiler farms
    Annemieke Smet
    Department of Bacteriology and Immunology, CODA CERVA VAR, Groeselenberg 99, 1180 Brussels, Belgium
    Antimicrob Agents Chemother 52:1238-43. 2008
    ..coli strains are often present in cloacal samples of broilers at the farm level in Belgium. The diversity of broad-spectrum beta-lactamases among these isolates is high, and they may act as a reservoir of ESBL and ampC genes...
  82. ncbi Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 57:176-89. 2006
    ..Early, empirical broad-spectrum antibiotic treatment is the established practice for febrile neutropenia. Several beta-lactams are accepted for monotherapy. We asked whether patients' outcomes are influenced by the chosen beta-lactam...
  83. pmc Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus
    Helio S Sader
    JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 52:1153-5. 2008
    ..All isolates had the Panton-Valentine leukocidin genes and staphylococcal cassette chromosome mec type IV, while 67.8% of isolates displayed pulsed-field gel electrophoresis clonal type USA300-0114...
  84. ncbi Differences in the changes in resistance patterns to third- and fourth-generation cephalosporins and piperacillin/tazobactam among Klebsiella pneumoniae and Escherichia coli clinical isolates following a restriction policy in a Greek tertiary care hospita
    George Petrikkos
    First Department of Propaedeutic Medicine, Infectious Diseases Laboratory, G K Daikos, Laikon General Hospital, Aghiou Thoma 17, Goudi, Athens 11527, Greece
    Int J Antimicrob Agents 29:34-8. 2007
    The aim of the present study was to investigate whether replacement of broad-spectrum cephalosporins (CEPs) by piperacillin/tazobactam (TZP) as first-line empirical therapy may have an effect on beta-lactam resistance among Klebsiella ..
  85. ncbi Changes in antimicrobial susceptibility in a population of Escherichia coli isolated from feedlot cattle administered ceftiofur crystalline-free acid
    T Courtney Lowrance
    Feedlot Research Group, Department of Agricultural Sciences, College of Agriculture, Science and Engineering, West Texas A and M University, Canyon, TX 79016, USA
    Am J Vet Res 68:501-7. 2007
    ..To determine effects of administration of ceftiofur crystalline-free acid (CCFA) on antimicrobial susceptibility of Escherichia coli in feedlot cattle...
  86. ncbi Prevalence and mechanisms of cephalosporin resistance in Enterobacteriaceae in London and South-East England
    Nicola A C Potz
    Healthcare Associated Infection and Antimicrobial Resistance Department, Health Protection Agency Centre for Infections 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 58:320-6. 2006
    ..To investigate the molecular epidemiology of Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs) in London and South-East England...
  87. pmc Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R126. 2010
    ..The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem would result in adequate serum drug concentrations in patients with severe sepsis and septic shock...
  88. pmc Cefotaxime-resistant Enterobacteriaceae isolates from a hospital in Warsaw, Poland: identification of a new CTX-M-3 cefotaxime-hydrolyzing beta-lactamase that is closely related to the CTX-M-1/MEN-1 enzyme
    M Gniadkowski
    Sera and Vaccines Central Research Laboratory, Warsaw, Poland
    Antimicrob Agents Chemother 42:827-32. 1998
    ..freundii strain causing routine urinary tract infections has been maintained for a relatively long time in the hospital environment...
  89. pmc In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates
    Louis Saravolatz
    St John Hospital and Medical Center, 19251 Mack Ave, Suite 333, Detroit, MI 48236, USA
    Antimicrob Agents Chemother 54:3027-30. 2010
    ..aureus (VRSA), heteroresistant VISA (hVISA), and daptomycin-nonsusceptible S. aureus (DNSSA) isolates. Ceftaroline may represent a bactericidal treatment option for infections caused by these pathogens...
  90. ncbi Activity of the new cephalosporin ceftaroline against bacteraemia isolates from patients with community-acquired pneumonia
    Ian Morrissey
    Quotient Bioresearch Limited, Microbiology, Newmarket Road, Fordham, Cambridgeshire CB75WW, UK
    Int J Antimicrob Agents 33:515-9. 2009
    ..These data confirm ceftaroline as a new cephalosporin with enhanced anti-Gram-positive activity and suggest that ceftaroline has the potential to be a useful new agent in the treatment of CAP-associated bacteraemic infections...
  91. pmc Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans
    M Muller
    Department of Clinical Pharmacology, University of Vienna, Austria
    Antimicrob Agents Chemother 40:2703-9. 1996
    ..This novel information may be useful for the rational development of dosage schedules and may improve predictions regarding therapeutic outcome...
  92. pmc Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing Enterobacteriaceae
    K S Thomson
    Center for Research in Antiinfectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Antimicrob Agents Chemother 45:3548-54. 2001
    ....
  93. pmc Effects of therapeutic ceftiofur administration to dairy cattle on Escherichia coli dynamics in the intestinal tract
    Randall S Singer
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 300A VSB, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Appl Environ Microbiol 74:6956-62. 2008
    ....
  94. pmc Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model
    Fabio Cafini
    Microbiology Department, School of Medicine, Universidad Complutense, Madrid, Spain
    PLoS ONE 5:e12041. 2010
    ..We explored cefditoren (CDN) total and free values of serum concentrations exceeding the MIC (t>MIC) related to efficacy in a mice sepsis model, and the effect of specific gammaglobulins on in-vitro phagocytosis and in-vivo efficacy...
  95. ncbi Safety profile of cefditoren. A pooled analysis of data from clinical trials in community-acquired respiratory tract infections
    J J Granizo
    Granadatos Pozuelo de Alarcón, Madrid, Spain
    Rev Esp Quimioter 22:57-61. 2009
    ..It is important to review the adverse events profile related to antibiotic exposure during the clinical development of drugs that are or have been recently included in the therapeutic armamentarium...
  96. ncbi Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units
    Juliana F Roos
    School of Pharmacy, University of Queensland, Brisbane, and Department of Intensive Care Medicine, Royal Brisbane Hospital, Australia
    J Antimicrob Chemother 58:987-93. 2006
    ....
  97. pmc Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp
    K S Kaye
    Division of Infectious Diseases and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 45:2628-30. 2001
    ..49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0...
  98. ncbi Cefepime-induced neurotoxicity: an underestimated complication of antibiotherapy in patients with acute renal failure
    D Chatellier
    Service de Reanimation Polyvalente, Hopital Roger Salengro, CHRU Université Lille 2, 59037 Lille, France
    Intensive Care Med 28:214-7. 2002
    ..To describe five new cases of life-threatening cefepime-induced neurotoxicity observed in a 2-year period...
  99. ncbi Efficacy of cefditoren in the treatment of upper respiratory tract infections: a pooled analysis of six clinical trials
    J J Granizo
    Granadatos, S L Pozuelo de Alarcon, Madrid, Spain
    Rev Esp Quimioter 21:14-21. 2008
    ..A pooled analysis of all upper respiratory tract infection studies performed with cefditoren (CDN) was performed...
  100. doi Cluster of multidrug-resistant Neisseria gonorrhoeae with reduced susceptibility to the newer cephalosporins in Northern Greece
    Eva Tzelepi
    J Antimicrob Chemother 62:637-9. 2008
  101. ncbi Evaluation of immediate allergic reactions to cephalosporins in non-penicillin-allergic patients
    Raz Somech
    Division of Immunology and Allergy, The Hospital for Sick Children, Toronto, Ont, Canada
    Int Arch Allergy Immunol 150:205-9. 2009
    b>Cephalosporins can induce severe or life-threatening IgE-mediated reactions in some individuals...

Research Grants62

  1. Challenges in beta-Lactamase Mediated Resistance
    Robert A Bonomo; Fiscal Year: 2013
    ..the catalysis and inhibition of PDC-3 [unreadable]-lactamase;a) To understand the interactions of PDC-3 with cephalosporins, carbapenems, and BATSIs on a deeper level, we will test the role of Thr105Ala, Thr289, Asn343, Asn346 and ..
  2. Gonococcal resistance to peroxynitrite
    Virginia L Clark; Fiscal Year: 2010
    ..resistance to antibiotics, such that the only CDC recommended treatment for gonorrhea is third generation cephalosporins. Thus, we need alternative approaches to controlling gonorrhea, such as vaccines or topical microbicides...
  3. Preserving beta-lactam utility against pathogens producing all classes of beta-la
    LUIGI XERRI; Fiscal Year: 2012
    ..b-Lactam antibiotics, including penicillins, cephalosporins, monobactams and carbapenems, are the most widely used antibiotic class in the U.S...
  4. Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    Henry F Chambers; Fiscal Year: 2013
    ..aureus strains were passaged in the presence of each of the two so-called "fifth generation" anti-MRSA cephalosporins, ceftobiprole and ceftaroline...
  5. Preserving beta-lactam utility vs pathogens producing any class of beta-lactamase
    LUIGI XERRI; Fiscal Year: 2013
    ..NDM-1 hydrolyzes all subclasses of [unreadable]-lactams (penicillins, cephalosporins and carbapenems) with the exception of monobactams (e.g., Aztreonam)...
  6. Isolating novel fungi for antibiotic discovery
    Losee Lucy Ling; Fiscal Year: 2012
    ..Many antimicrobials, including ?-lactams and cephalosporins derive from culturable representatives of this group of microorganisms...
  7. Cranberry: Interactions with Anti-infectious Agents
    Gail Anderson; Fiscal Year: 2005
    ..UTI are typically responsive to trimethoprim-sulfamethoxazole, quinolones, and the beta-lactams (penicillins, cephalosporins)...
  8. BETA LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCE
    Timothy Palzkill; Fiscal Year: 2013
    ..The ?-lactam antibiotics, such as the penicillins and cephalosporins, are among the most often used antimicrobials...
  9. Redesign of the Carbapenem Scaffold
    Bret M Benton; Fiscal Year: 2012
    ..In general, carbapenemases have extremely broad substrate specificity, hydrolyzing penicillins, cephalosporins, carbapenems, and often even monobactams...
  10. Developing and Testing a Novel Geometric Model of Protein Adaptation
    DANIEL MICHAEL WEINREICH; Fiscal Year: 2013
    ..g. penicillin and the cephalosporins) represent 65% of the world antibiotic market [65], and the TEM serine b-lactamases are the chief source of ..
  11. Role of Signal Transduction in Resistance to Cell-Wall Antimicrobials in MRSA
    ROBERT S contact DAUM; Fiscal Year: 2010
    ..to treat MRSA isolates that are resistant to all available ss-lactam antibiotics including penicillins and cephalosporins. Moreover, the effectiveness of the glycopeptide antibiotic vancomycin, long regarded as the antibiotic of ..
  12. Novel Metallo-beta-lactamase Inhibitors
    LUIGI XERRI; Fiscal Year: 2012
    ..e. penicillins, cephalosporins, carbapenems) both in hospital and community settings1,5,6...
  13. Clinical Trial of Ceftriaxone in Subjects with ALS
    Merit E Cudkowicz; Fiscal Year: 2012
    ..Several cephalosporins, including Ceftriaxone, were hits in ALS relevant assays including models suggesting increased expression of ..
  14. Development of Protein-Based Beta-lactam Antibiotic Resistance Diagnostics
    Timothy Palzkill; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): ?-lactam antibiotics such as the penicillins and cephalosporins are the most often used antibiotics and account for more than 60% of total world consumption of antimicrobials...
  15. Genomic epidemiology of Neisseria gonorrhoeae with elevated MICs to cefixime
    Yonatan H Grad; Fiscal Year: 2013
    ..to all the first line antibiotics that have been used to treat it, including now resistance to broad-spectrum cephalosporins. The main goal of this research project is to understand more about how antibiotic resistance emerges and ..
  16. BETA LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCE
    Timothy Palzkill; Fiscal Year: 2010
    ..is the development of resistance to p-lactam antibiotics, p-lactam antibiotics, such as the penicillins and cephalosporins, are among the most frequently used antimicrobialagents...
  17. Development of New Beta-Lactamase Inhibitors for Resistant Category B Food/Water-
    CHRISTOPHER JOHN BURNS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): (-Lactam antibiotics, specifically third-generation cephalosporins, are critical for the treatment of complicated diarrheal illness due to many Category B bacterial food and waterborne pathogens...
  18. Elucidating beta-lactamase functional mechanisms via evolutionary conservation
    Dennis R Livesay; Fiscal Year: 2013
    ..Conversely, second generation cephalosporins are also effective against gram-negative bacteria because they are able to penetrate the cell wall...
  19. Mechanistic studies and inhibition strategies for antibiotic resistance
    Focco van den Akker; Fiscal Year: 2010
    ..due to the bacterial expression of beta-lactamases that degrade beta-lactam antibiotics including penicillins, cephalosporins, and the "last resort" carbapenem antibiotics...
  20. Structure, Function and Inhibition of Beta-lactamases
    Brian K Shoichet; Fiscal Year: 2013
    ..Initially introduced to confer stability to ?-lactamases, 3rd generation cephalosporins have promoted the evolution of ?-lactamase mutants...
  21. Conformational Flexibility and Antibiotic Resistance
    Jeffrey W Peng; Fiscal Year: 2012
    ..g. penicillins, carbapenems, cephalosporins), which remain the most widely used anti-infectives in the clinic...
  22. PENICILLIN RESPONSE GENES IN DRUG-RESISTANT PNEUMOCOCCI
    Alexander Tomasz; Fiscal Year: 1999
    ..Recent and alarming developments include: the appearance of resistance to third-generation cephalosporins; increase in the penicillin MIC and demonstration of the capacity of certain multiresistant clones to spread ..
  23. REACTIVITY MODELS FOR ISOPENICILLIN N SYNTHETASE
    PATRICIA SHAPLEY; Fiscal Year: 1992
    Beta-Lactam antibiotics, including the penicillins, cephalosporins and monobactams, are very important in the treatment of bacterial infections...
  24. Evolution and inhibition of beta-lactamase activity in antibiotic resistance
    Yu Chen; Fiscal Year: 2013
    ..bacterial pathogens against [unreadable]-lactam antibiotics, which include the widely used penicillins and cephalosporins, as well as last resort antibiotics such as the carbapenems...
  25. New Drug for Treatment of Chronic Bacterial Infection
    Gyanu Lamichhane; Fiscal Year: 2013
    ..One the most successful class of antibiotics in human clinical use, namely the [unreadable]-lactams and cephalosporins, targets the classical 4?3 linkages...
  26. Antimicrobial Use in Dialysis Units
    ERIKA M D'AGATA; Fiscal Year: 2013
    ..5% of antimicrobial doses were prescribed inappropriately, as per national guidelines. Third/fourth generation cephalosporins, followed by vancomycin, were the most common antimicrobials prescribed inappropriately...
  27. Mycoplasma Genitalium and Pelvic Inflammatory Disease
    Catherine Haggerty; Fiscal Year: 2007
    ..Therefore, it is likely resistant to cell wall inhibiting cephalosporins, including cefoxitin...
  28. Oxacillinase and Bacterial beta-Lactam Resistance
    James Knox; Fiscal Year: 2003
    ..bacterial beta-lactamase which provides clinical resistance to beta-lactam antibiotics (penicillins and cephalosporins)...
  29. BETA-LACTAM ANTIBIOTIC ALLERGY
    Timothy Sullivan; Fiscal Year: 1992
    IgE antibody mediated reactions to beta-lactam antibiotics (penicillins, cephalosporins, carbapenems, and monobactams) frequently complicate therapy with these agents and impose a serious limitation on their use...
  30. Determining the fitness effects of antibiotic resistance genes
    Miriam Barlow; Fiscal Year: 2010
    ..These studies will focus specifically on TEM, SHV, and CTX-M 2-lactamases, which hydrolyze penicillins, cephalosporins, and other 2-lactam antibiotics...
  31. Mechanistic Studies of Carbapenem Synthase (CarC)
    COURTNEY JAMES HASTINGS; Fiscal Year: 2013
    ..The carbapenem class of antibiotics are much more resistant to 2-lactamases than the penicillins and cephalosporins, and as such they are clinically valuable in the treatment of resistant infections...
  32. MORPHOGENESIS OF THE MUREIN SACCULUS OF ESCHERICHIA COLI
    Michael Hochberg; Fiscal Year: 1990
    ..of bacteria to B-lactams antibiotics; bacteria which are not growing are resistant to most penicillin and cephalosporins and conversely bacteria are most sensitive to B-lactams when they are dividing (forming a septum) and ..
  33. Ceftiofur use in cattle: a public health concern?
    Susan Sanchez; Fiscal Year: 2004
    ..The hypothesis is that the therapeutic use of ceftiofur in food animals is selecting for resistance to cephalosporins in members of the Family Enterobacteriaceae...
  34. Clinical Trial of Ceftriaxone in ALS
    Merit Cudkowicz; Fiscal Year: 2004
    ..Several cephalosporins, including ceftriaxone showed hits in ALS relevant assays...
  35. MECHANISMS OF ANTIBIOTIC RESISTANCE IN THE NURSING HOME
    ROBERT BONOMO; Fiscal Year: 1999
    ..nursing home, these infections are often treated empirically using costly extended spectrum (third generation) cephalosporins or beta-lactam beta- lactamase inhibitor combinations (amoxacillin/clavulanic acid)...
  36. METALLOENZYMES AND ANTIBIOTIC RESISTANCE IN BACTERIA
    Robert Shaw; Fiscal Year: 1992
    ..by pathogenic bacteria which allow them to become resistant to beta-lactam antibiotics such as penicillins and cephalosporins. These enzymes efficiently catalyze amide hydrolysis of the beta-lactam rings in these antibiotics thereby ..
  37. High-Throughput Assay for the Intestinal Peptide Transporter
    Peter Swaan; Fiscal Year: 2005
    ..tripeptides, and mediates the absorption of a wide range of therapeutic compounds, such as aminopenicillins, cephalosporins, and 'angiotensin converting enzyme' (ACE) inhibitors...
  38. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  39. Dual Purpose b-Lactamase Inhibitors
    JOHN BUYNAK; Fiscal Year: 2004
    ..A group of scientists, including chemists, microbiologists, enzymologists, and crystallographers has been assembled to allow rapid optimization of SAR. ..
  40. Rural Trial of Clinic Order Entry with Decision Support
    Matthew Samore; Fiscal Year: 2006
    ..The cost impact of the intervention will be measured to allow a comprehensive assessment of the value of this HIT. [unreadable] [unreadable]..
  41. New Nosocomial Interventions to Decrease Antimicrobial Resistance Transmission
    Anthony Harris; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. Study design importance in analyzing emerging pathogens
    Anthony Harris; Fiscal Year: 2005
    ..The second aim will be done by combining epidemiological relatedness and molecular relatedness through pulse-field gel electrophoresis of ESBL cultures to quantify the importance of patient to patient transmission. ..
  43. Genetic approaches to protein-protein interactions mediating antibiotic resistanc
    CHRISTOPHER KRISTICH; Fiscal Year: 2009
    ....
  44. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  45. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  46. STAPHYLOCOCCUS AUREUS FIBRONECTIN-BINDING ADHESINS
    Barbara Menzies; Fiscal Year: 2003
    ..The use of FnBP as an anti-adhesin presents a novel therapeutic tool for the prevention of S. aureus infections. ..
  47. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  48. THE SIGNIFICANCE OF FUNGURIA IN HOSPITALIZED PATIENTS
    Loren Miller; Fiscal Year: 2004
    ....
  49. METALLO BETA LACTAMASE FROM X MALTOPHILIA
    Michael Crowder; Fiscal Year: 2002
    ....
  50. Pain Medication Use & Risk Factors for Opioid Dependence
    Daniel Solomon; Fiscal Year: 2004
    ..Our goal is to use the results of the proposed research to inform a future intervention to improve opioid prescribing within this large pharmacy benefits program. ..
  51. Type II secretion system of P. aeruginosa in acute lung infection
    Reuben Ramphal; Fiscal Year: 2010
    ..We wish to examine which of the many known toxins are involved in death and to explore new methods to block secretion of the toxins that may eventually be useful for therapy. ..
  52. AMINO ACID TRANSPORTER B: PHARMACOLOGY & THERAPEUTIC USE
    Malliga Ganapathy; Fiscal Year: 2006
    ....
  53. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    ..By knocking each of these genes out and testing for loss of virulence, we hope to learn which genes code for virulence. Once these genes are identified, strategies to block their effects may be developed. ..
  54. ica phase variation in Staphylococcus epidermidis
    PAUL FEY; Fiscal Year: 2005
    ..epidermidis pathogenesis and biology. Novel means to prevent and treat biomaterial-based infections may be suggested as a result of these studies. ..
  55. Human studies of Listeria monocytogenes vectors
    Elizabeth Hohmann; Fiscal Year: 2008
    ..These studies will provide important data on the feasibility and utility of using Listeria monocytogenes vectors in humans. ..
  56. Human Studies of Attenuated Salmonella Vectors
    Elizabeth Hohmann; Fiscal Year: 2007
    ..The major goal of the project is to provide practical safety and immunogenicity data in humans which will help efficiently direct development of live bacterial vectors. ..
  57. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. A randomized trial of influenza vaccination of Hutterite children
    Mark Loeb; Fiscal Year: 2006
    ..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..
  59. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..